Minsoo Koh, Hyesol Lim, Hao Jin, Minjoo Kim, Yeji Hong, Young Keun Hwang, Yunjung Woo, Eun-Sook Kim, Sun Young Kim, Kyung Mee Kim, Hyun Kyung Lim, Joohee Jung, Sujin Kang, Boyoun Park, Han-Byoel Lee, Wonshik Han, Myung-Shik Lee, Aree Moon
Triple-negative breast cancer (TNBC) is associated with a poor prognosis and metastatic growth. TNBC cells frequently undergo macroautophagy/autophagy, contributing to tumor progression and chemotherapeutic resistance. ANXA2 (annexin A2), a potential therapeutic target for TNBC, has been reported to stimulate autophagy. In this study, we investigated the role of ANXA2 in autophagic processes in TNBC cells. TNBC patients exhibited high levels of ANXA2, which correlated with poor outcomes. ANXA2 increased LC3B-II levels following bafilomycin A1 treatment and enhanced autophagic flux in TNBC cells...
January 30, 2024: Autophagy