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annexin a1

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https://www.readbyqxmd.com/read/29115663/endogenous-annexin-a1-anxa1-modulates-early-phase-gestation-and-offspring-sex-ratio-skewing
#1
Cristina Bichels Hebeda, Isabel Daufenback Machado, Isadora Reif-Silva, Jusciele Brogin Moreli, Sonia Maria Oliani, Suchita Nadkarni, Mauro Perretti, Estela Bevilacqua, Sandra H P Farsky
Annexin A1 (AnxA1) is a glucocorticoid-regulated anti-inflammatory protein secreted by phagocytes and other specialised cells. In the endocrine system, AnxA1 controls secretion of steroid hormones and it is abundantly expressed in the testis, ovaries, placenta and seminal fluid, yet its potential modulation of fertility has not been described. Here we observed that AnxA1 knockout (KO) mice delivered a higher number of pups, with a higher percentage of female offsprings. This profile was not dependent on the male features, as sperm from KO male mice did not present functional alterations, and had an equal proportion of Y and X chromosomes, comparable to wild type (WT) male mice...
November 8, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29101297/mesenchymal-stromal-cells-improve-human-islet-function-through-released-products-and-extracellular-matrix
#2
Ahmed A Arzouni, Andreia Vargas-Seymour, Chloe L Rackham, Paramjeet Dhadda, Guo-Cai Huang, Pratik Choudhary, Nance Nardi, Aileen J F King, Peter M Jones
Aims: The aims of the current study were (i) to determine whether the reported beneficial effects of mesenchymal stromal cells (MSCs) on mouse islet function extend to clinically relevant human tissues (islets and MSCs), enabling translation into improved protocols for clinical human islet transplantation; and (ii) to identify possible mechanisms through which human MSCs influence human islet function. Materials and methods: Human islets were co-cultured with human adipose tissue-derived MSCs (hASCs) or pretreated with its products - extracellular matrix (ECM) and annexin A1 (ANXA1)...
November 3, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29091952/evaluation-of-mirna-196a2-and-apoptosis-related-target-genes-anxa1-dffa-and-pdcd4-expression-in-gastrointestinal-cancer-patients-a-pilot-study
#3
Manal S Fawzy, Eman A Toraih, Afaf Ibrahiem, Hala Abdeldayem, Amany O Mohamed, Mohamed M Abdel-Daim
Previous reports have suggested the significant association of miRNAs aberrant expression with tumor initiation, progression and metastasis in cancer, including gastrointestinal (GI) cancers. The current preliminary study aimed to evaluate the relative expression levels of miR-196a2 and three of its selected apoptosis-related targets; ANXA1, DFFA and PDCD4 in a sample of GI cancer patients. Quantitative real-time PCR for miR-196a2 and its selected mRNA targets, as well as immunohistochemical assay for annexin A1 protein expression were detected in 58 tissues with different GI cancer samples...
2017: PloS One
https://www.readbyqxmd.com/read/29079698/transgenic-mice-expressing-human-proteinase-3-exhibit-sustained-neutrophil-associated-peritonitis
#4
Katherine R Martin, Magali Pederzoli-Ribeil, Emeline Pacreau, Sabrina S Burgener, Albert Dahdah, Céline Candalh, Evelyne Lauret, Marc Foretz, Luc Mouthon, Bruno Lucas, Nathalie Thieblemont, Charaf Benarafa, Pierre Launay, Véronique Witko-Sarsat
Proteinase 3 (PR3) is a myeloid serine protease expressed in neutrophils, monocytes, and macrophages. PR3 has a number of well-characterized proinflammatory functions, including cleaving and activating chemokines and controlling cell survival and proliferation. When presented on the surface of apoptotic neutrophils, PR3 can disrupt the normal anti-inflammatory reprogramming of macrophages following the phagocytosis of apoptotic cells. To better understand the function of PR3 in vivo, we generated a human PR3 transgenic mouse (hPR3Tg)...
October 27, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29057162/augmenting-endogenous-levels-of-retinal-annexin-a1-suppresses-uveitis-in-mice
#5
Peter J Gardner, Samia Yazid, Joana Ribeiro, Robin R Ali, Andrew D Dick
PURPOSE: The purpose of this study was to examine the expression of the anti-inflammatory protein Annexin A1 (AnxA1) in mice and human retinae during uveitis and to determine whether local administration of human recombinant AnxA1 (hrAnxA1) can suppress uveitis in mice. METHODS: Retinal sections from mice (healthy normal and uveitis) and postmortem human (no history of eye disease (n = 5) and uveitis (n = 7)) were stained for AnxA1 expression and imaged by immunofluorescence microscopy...
September 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29044433/pregnancy-induced-changes-in-metabolome-and-proteome-in-ovine-uterine-flushings
#6
Jared J Romero, Bethany E Liebig, Corey D Broeckling, Jessica E Prenni, Thomas R Hansen
Mass spectrometry (MS) approaches were used herein to identify metabolites and proteins in uterine flushings (UF) that may contribute to nourishing the conceptus. Ovine uteri collected on Day 12 of the estrous cycle (n = 5 ewes exposed to vasectomized ram) or Days 12 (n = 4), 14 (n = 5), or 16 (n = 5) of pregnancy (bred with fertile ram) were flushed using buffered saline. Metabolites were extracted using 80% methanol and profiled using ultraperformance liquid chromatography (LC) tandem mass spectrometry. The proteome was examined by digestion with trypsin, followed by the analysis of peptides with LC-MS/MS...
August 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29039553/proteomic-analysis-of-serum-deprivation-in-tongue-squamous-cell-carcinoma
#7
Junfeng Zhang, Wei Dong, Yufen Meng, Miao Jiang, Zhen Zhan
The occurrence of tongue squamous cell carcinoma (TSCC) is closely correlated with serum components; however, the detailed mechanism remains to be fully elucidated. Proteomic analysis contributed to the discovery of potential biomarkers and provided an insight into TSCC at a molecular level. The present study investigated the effect of serum deprivation on the Tca‑8113 TSCC cell line through protein profiling using two‑dimensional gel electrophoresis and mass spectrometry, with the aim of improving TSCC diagnosis...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29030970/annexin-a1-annexin-a2-and-dyrk-1b-are-upregulated-during-gas1-induced-cell-cycle-arrest
#8
G Pérez-Sánchez, A Jiménez, M A Quezada-Ramírez, E Estudillo, A E Ayala-Sarmiento, G Mendoza-Hernández, Justino Hernández-Soto, F C Hernández-Hernández, F E Cázares-Raga, J Segovia
GAS1 is a pleiotropic protein that has been investigated because of its ability to induce cell proliferation, cell arrest, and apoptosis, depending on the cellular or the physiological context in which it is expressed. At this point, we have information about the molecular mechanisms by which GAS1 induces proliferation and apoptosis; but very few studies have been focused on elucidating the mechanisms by which GAS1 induces cell arrest. With the aim of expanding our knowledge on this subject, we first focused our research on finding proteins that were preferentially expressed in cells arrested by serum deprivation...
October 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29021293/ppar%C3%AE-ligand-induced-annexin-a1-expression-determines-chemotherapy-response-via-deubiquitination-of-death-domain-kinase-rip-in-triple-negative-breast-cancers
#9
Luxi Chen, Yi Yuan, Shreya Kar, Madhu M Kanchi, Suruchi Arora, Ji E Kim, Pei F Koh, Einas Yousef, Ramar P Samy, Muthu K Shanmugam, Tuan Z Tan, Sung W Shin, Frank Arfuso, Han M Shen, Henry Yang, Boon C Goh, Joo I Park, Louis Gaboury, Peter E Lobie, Gautam Sethi, Lina H K Lim, Alan P Kumar
Metastatic breast cancer is still incurable so far; new specifically targeted and more effective therapies for triple-negative breast cancer (TNBC) are required in the clinic. In this study, our clinical data have established that basal and claudin-low subtypes of breast cancer (TNBC types) express significantly higher levels of Annexin A1 (ANXA1) with poor survival outcomes. Using human cancer cell lines that model the TNBC subtype, we observed a strong positive correlation between expression of ANXA1 and PPARγ...
August 15, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28963375/expression-correlates-between-annexin-a1-and-a2-autoantibodies-in-patients-with-behcet-s-disease
#10
Muhammad Hussain, Peng Chen, Guang Mei, Yongzhe Li, Hongwu Du
The autoantibodies profile of Behcet's disease (BD) is yet incompletely understood. Annexins are a family of highly conserved proteins which are involved in some human autoimmune diseases. Autoantibodies directed toward Annexin A1 and A2 are involved in BD pathology, but correlation in their clinical role is controversial.Our study aim is to estimate and evaluate the expression correlation between Annexin A1 and A2 autoantibodies in BD patients. We have designed and implemented different technical approaches to prove the hypothesis...
September 29, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28928730/fpr2-a-novel-promising-target-for-the-treatment-of-influenza
#11
REVIEW
Marie-Christine Alessi, Nicolas Cenac, Mustapha Si-Tahar, Béatrice Riteau
The Formyl-peptide receptor-2 (FPR2) is a seven transmembrane G protein-coupled receptor, which plays an important role in sensing of bacteria and modulation of immune responses. FPR2 is also used by viruses for their own profit. Annexin A1, one of the multiple ligands of FPR2, is incorporated in the budding virus membrane of influenza A viruses (IAV). Thereby, once IAV infect a host cell, FPR2 is activated. FPR2-signaling leads to an increase in viral replication, a dysregulation of the host immune response and a severe disease...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28912778/neuroprotective-effects-of-annexin-a1-tripeptide-after-deep-hypothermic-circulatory-arrest-in-rats
#12
Zhiquan Zhang, Qing Ma, Bijal Shah, G Burkhard Mackensen, Donald C Lo, Joseph P Mathew, Mihai V Podgoreanu, Niccolò Terrando
Resolution agonists, including lipid mediators and peptides such as annexin A1 (ANXA1), are providing novel approaches to treat inflammatory conditions. Surgical trauma exerts a significant burden on the immune system that can affect and impair multiple organs. Perioperative cerebral injury after cardiac surgery is associated with significant adverse neurological outcomes such as delirium and postoperative cognitive dysfunction. Using a clinically relevant rat model of cardiopulmonary bypass (CPB) with deep hypothermic circulatory arrest (DHCA), we tested the pro-resolving effects of a novel bioactive ANXA1 tripeptide (ANXA1sp) on neuroinflammation and cognition...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28901509/ct45a1-sirna-silencing-suppresses-the-proliferation-metastasis-and-invasion-of-lung-cancer-cells-by-downregulating-the-erk-creb-signaling-pathway
#13
Feng Tang, Shengjun Tang, Xiaolong Guo, Chao Yang, Ke Jia
The aim of the present study was to investigate the role of the cancer‑testis antigen family 45 member A1 (CT45A1) in the proliferation, apoptosis, invasion and metastasis of lung cancer cells, and the associated molecular mechanisms. Western blotting determined that the expression of CT45A1 in normal lung cells was far lower than that observed in lung cancer cells. Following the transfection of CT45A1 small (or short) interfering (si)RNA and its negative control into A549 cells using Lipofectamine 2000, the CT45A1 protein and mRNA levels were determined further by western blotting and reverse transcription‑polymerase chain reaction...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28901452/screening-critical-genes-associated-with-malignant-glioma-using-bioinformatics-analysis
#14
Yonggang Xu, Jie Wang, Yanbin Xu, Hong Xiao, Jianhua Li, Zhi Wang
Malignant gliomas are high‑grade gliomas, which are derived from glial cells in the spine or brain. To examine the mechanisms underlying malignant gliomas in the present study, the expression profile of GSE54004, which included 12 grade II astrocytomas, 33 grade III astrocytomas and 98 grade IV astrocytomas, was downloaded from the Gene Expression Omnibus. Using the Limma package in R, the differentially expressed genes (DEGs) in grade III, vs. grade II astrocytoma, grade IV, vs. grade II astrocytoma, and grade IV, vs...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28827575/immune-system-deregulation-in-hypertensive-patients-chronically-ras-suppressed-developing-albuminuria
#15
Marta Martin-Lorenzo, Laura Gonzalez-Calero, Paula J Martinez, Montserrat Baldan-Martin, Juan Antonio Lopez, Gema Ruiz-Hurtado, Fernando de la Cuesta, Julián Segura, Jesús Vazquez, Fernando Vivanco, Maria G Barderas, Luis M Ruilope, Gloria Alvarez-Llamas
Albuminuria development in hypertensive patients is an indicator of higher cardiovascular (CV) risk and renal damage. Chronic renin-angiotensin system (RAS) suppression facilitates blood pressure control but it does not prevent from albuminuria development. We pursued the identification of protein indicators in urine behind albuminuria development in hypertensive patients under RAS suppression. Urine was collected from 100 patients classified in three groups according to albuminuria development: (a) patients with persistent normoalbuminuria; (b) patients developing de novo albuminuria; (c) patients with maintained albuminuria...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821634/lipidomic-and-proteomic-analysis-of-exosomes-from-mouse-cortical-collecting-duct-cells
#16
Viet D Dang, Kishore Kumar Jella, Ragy R T Ragheb, Nancy D Denslow, Abdel A Alli
Exosomes are endosome-derived nanovesicles that are involved in cellular communication and signaling. Exosomes are produced by epithelial cells and are found in biologic fluids including blood and urine. The packaged material within exosomes includes proteins and lipids, but the molecular comparison within exosome subtypes is largely unknown. The purpose of this study was to investigate differences between exosomes derived from the apical plasma membrane and basolateral plasma membrane of polarized murine cortical collecting duct principal cells...
August 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28811325/ppar%C3%AE-ligand-induced-annexin-a1-expression-determines-chemotherapy-response-via-deubiquitination-of-death-domain-kinase-rip-in-triple-negative-breast-cancers
#17
Luxi Chen, Yi Yuan, Shreya Kar, Madhu M Kanchi, Suruchi Arora, Ji E Kim, Pei F Koh, Einas Yousef, Ramar P Samy, Muthu K Shanmugam, Tuan Z Tan, Sung W Shin, Frank Arfuso, Han M Shen, Henry Yang, Boon C Goh, Joo I Park, Louis Gaboury, Peter E Lobie, Gautam Sethi, Lina Hk Lim, Alan P Kumar
Metastatic breast cancer is still remain incurable so far, new specifically targeted and more effective therapies for triple negative breast cancer (TNBC) are required in the clinic. In this study, our clinical data has established that basal and claudin-low subtypes of breast cancer (TNBC types) express significantly higher levels of Annexin A1 (ANXA1) with poor survival outcomes. Using human cancer cell lines which model the TNBC subtype, we observed a strong positive correlation between expression of ANXA1 and Peroxisome Proliferator-Activated Receptor gamma (PPARγ)...
August 15, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28809781/ac2-26-an-annexin-a1-peptide-attenuates-ischemia-reperfusion-induced-acute-lung-injury
#18
Wen-I Liao, Shu-Yu Wu, Geng-Chin Wu, Hsin-Ping Pao, Shih-En Tang, Kun-Lun Huang, Shi-Jye Chu
Annexin A1 (AnxA1) is an endogenous protein that modulates anti-inflammatory processes, and its therapeutic potential has been reported in a range of inflammatory diseases. The effect of AnxA1 on ischemia-reperfusion (IR)-induced lung injury has not been examined. In this study, isolated, perfused rat lungs were subjected to IR lung injury induced by ischemia for 40 min, followed by reperfusion for 60 min. The rat lungs were randomly treated with vehicle (phosphate-buffered saline), and Ac2-26 (an active N-terminal peptide of AnxA1) with or without an N-formyl peptide receptor (FPR) antagonist N-Boc-Phe-Leu-Phe-Leu-Phe (Boc2)...
August 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28754915/annexin-a1-down-regulation-in-head-and-neck-squamous-cell-carcinoma-is-mediated-via-transcriptional-control-with-direct-involvement-of-mir-196a-b
#19
Saúl Álvarez-Teijeiro, Sofía T Menéndez, M Ángeles Villaronga, Emma Pena-Alonso, Juan P Rodrigo, Reginald O Morgan, Rocío Granda-Díaz, Cecilia Salom, M Pilar Fernandez, Juana M García-Pedrero
Annexin A1 (ANXA1) down-regulation is an early and frequent event in the development of head and neck squamous cell carcinomas (HNSCC). In an attempt to identify the underlying mechanisms of reduced ANXA1 protein expression, this study investigated ANXA1 mRNA expression in HNSCC specimens by both in situ hybridization and RT-qPCR. Results showed a perfect concordance between the pattern of ANXA1 mRNA and protein detected by immunofluorescence in tumors, precancerous lesions and normal epithelia, reflecting that ANXA1 down-regulation occurs at transcriptional level...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28736517/resolution-of-cochlear-inflammation-novel-target-for-preventing-or-ameliorating-drug-noise-and-age-related-hearing-loss
#20
REVIEW
Gilda M Kalinec, Gwen Lomberk, Raul A Urrutia, Federico Kalinec
A significant number of studies support the idea that inflammatory responses are intimately associated with drug-, noise- and age-related hearing loss (DRHL, NRHL and ARHL). Consequently, several clinical strategies aimed at reducing auditory dysfunction by preventing inflammation are currently under intense scrutiny. Inflammation, however, is a normal adaptive response aimed at restoring tissue functionality and homeostasis after infection, tissue injury and even stress under sterile conditions, and suppressing it could have unintended negative consequences...
2017: Frontiers in Cellular Neuroscience
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