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JOURNAL ARTICLE
Madhileti Sravani, Sheeba Collins, Arpana Iyengar
INTRODUCTION: Dietary acid load (DAL), which reflects the balance between acid- and alkaline-forming foods, is a modifiable risk factor for metabolic acidosis in CKD. Owing to the paucity of data in the Indian context, we undertook this cross-sectional study to estimate DAL and assess acid and alkaline food consumption in children with CKD2-5D (Chronic kidney disease stage 2 to 5 and 5D-those on hemodialysis). METHODS: Clinical profile, dietary assessment of energy, protein intake/deficits, and macronutrients were noted and computed using software created by the division of nutrition, St John's research institute based on Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines in clinically stable children with CKD2-5D...
2024: Indian Journal of Nephrology
#22
REVIEW
Chukwuemeka A Umeh, Tamanna Mohta, Gagan Kaur, Roland Truong, Puja Darji, Chong Vue, Vijaya Bhargavi Cherukuri, Benson Eghreriniovo, Rahul Gupta
Acetazolamide and thiazide diuretics have been combined with loop diuretics to overcome diuretic resistance in heart failure patients. However, recent studies have assessed the upfront combination of acetazolamide and hydrochlorothiazide with loop diuretics in hospitalized patients with acute decompensated heart failure without loop diuretic resistance. We reviewed two recent randomized controlled trials on the upfront use of acetazolamide and thiazide diuretics in acute decompensated heart failure, respectively...
April 2024: Cardiology Research
#23
JOURNAL ARTICLE
Ping-Hsun Lu, Chien-Cheng Lai, Ling-Ya Chiu, I-Hsin Lin, Chih-Chin Iou, Po-Hsuan Lu
OBJECTIVE: Uremic pruritus (UP) is a prevalent and troublesome condition affecting individuals with end-stage renal failure, which results in intense pruritus, depression, as well as poor quality of sleep, significantly impacting their quality of life. According to previous studies, acupuncture and acupoint stimulation have been shown to provide additional benefits in treating UP in dialysis patients. In addition, using acupoints combination may yield superior effectiveness compared to utilizing a singular acupoint...
2024: Tzu chi medical journal
#24
Nasser Simforoosh, Mohammad Sajjad Zabihi, Mehdi Dadpour
Mixed epithelial and stromal tumor (MEST) of the kidney is not a common diagnosis. This tumor usually mimics solid-cystic malignant renal tumors and most cases are treated surgically. Here, we presented a 35-year-old female with simultaneous two separate large solid-cystic masses with contrast enhancement in lower and upper pole of left kidney which were managed surgically via partial nephrectomy. Microscopic evaluation showed solid-cystic tumor with variably sized cysts lined by flattened to cuboidal epithelium that was compatible with MEST...
May 2024: Urology Case Reports
#25
REVIEW
Yilin Tao, Ruixiang Luo, Yuanbing Xiang, Min Lei, Xuan Peng, Yao Hu
The Bailing Capsule is a commonly used traditional Chinese medicine for the treatment of chronic kidney disease (CKD). However, its therapeutic effects and pharmacological mechanisms have not been fully explored. In this study, we integrated meta-analysis and network pharmacology to provide scientific evidence for the efficacy and pharmacological mechanism of Bailing Capsule in treating CKD. We conducted searches for randomized controlled studies matching the topic in PubMed, the Cochrane Library, Embase, Web of Science, and the Wanfang Database, and screened them according to predefined inclusion and exclusion criteria...
2024: Frontiers in Pharmacology
#26
JOURNAL ARTICLE
Fatemeh Noroozi, Masoumeh Asle-Rousta, Rahim Amini, Zeinab Sahraeian
OBJECTIVES: Renal and testicular disorders are primarily associated with oxidative damage and inflammation. Here, alpha-pinene (a type of monoterpene) was investigated for its effect on oxidative/nitrosative stress and the expression of inflammatory and apoptotic factors in the kidneys and testes of rats treated with CCl4 . MATERIALS AND METHODS: CCl4 was injected intraperitoneally (IP) at a dose of 2 ml/kg (twice a week for six weeks). Alpha-pinene (50 mg/kg/day, IP) was also treated during the same period...
2024: Iranian Journal of Basic Medical Sciences
#27
Brennan Marsh-Armstrong, Fernanda Pacheco, Christian Dameff, Jeffrey Tully
Background: Cybersecurity incidents affecting hospitals have grown in prevalence and consequence over the last two decades, increasing the importance of cybersecurity preparedness and response training to minimize clinical disruptions. This work describes the development, execution, and post-exercise assessment of a novel simulation scenario consisting of four interlocking intensive care unit (ICU) patient scenarios. This simulation was designed to demonstrate the management of acute pathologies without access to conventional treatment methods during a cybersecurity incident in order to raise clinician awareness of the increasing incidence and patient safety implications of such events...
April 5, 2024: Research Square
#28
JOURNAL ARTICLE
Subrata Batabyal, Chinenye Idigo, Darryl Narcisse, Adnan Dibas, Samarendra Mohanty
Cells from different organs in the body experience a range of mechanical and osmotic pressures that change in various diseases, including neurological, cardiovascular, ophthalmological, and renal diseases. Here, we demonstrate the use of an engineered Sensor-Actuator-Modulator (SAM) of microbial origin derived from a mechanosensitive channel of large conductance (MscL) for sensing external mechanical stress and modulating activities of mammalian cells. SAM is reliably expressed in the mammalian cell membrane and acts as a tension-activated pressure release valve...
April 30, 2024: Heliyon
#29
Fabio Vescini, Giorgio Borretta, Iacopo Chiodini, Marco Boniardi, Marina Carotti, Elena Castellano, Cristiana Cipriani, Cristina Eller-Vainicher, Sandro Giannini, Maurizio Iacobone, Antonio Stefano Salcuni, Federica Saponaro, Stefano Spiezia, Annibale Versari, Guido Zavatta, Zuzana Mitrova, Rosella Saulle, Simona Vecchi, Debora Antonini, Michele Basile, Alexia Giovanazzi, Agostino Paoletta, Enrico Papini, Agnese Persichetti, Irene Samperi, Alessandro Scoppola, Roberto Novizio, Pietro Giorgio Calò, Filomena Cetani, Luisella Cianferotti, Sabrina Corbetta, Maria Luisa De Rimini, Alberto Falchetti, Giovanni Iannetti, Stefano Laureti, Celestino Pio Lombardi, Bruno Madeo, Claudio Marcocci, Sandro Mazzaferro, Vittorio Miele, Salvatore Minisola, Andrea Palermo, Jessica Pepe, Alfredo Scillitani, Laura Tonzar, Franco Grimaldi, Renato Cozzi, Roberto Attanasio
AIM: This guideline (GL) is aimed at providing a clinical practice reference for the management of sporadic primary hyperparathyroidism (PHPT) in adults. PHPT management in pregnancy was not considered. METHODS: This GL has been developed following the methods described in the Manual of the Italian National Guideline System. For each question, the panel appointed by Associazione Medici Endocrinology (AME) and Società Italiana dell'Osteoporosi, del Metabolismo Minerale e delle Malattie dello Scheletro (SIOMMMS) identified potentially relevant outcomes, which were then rated for their impact on therapeutic choices...
December 23, 2023: Endocrine, Metabolic & Immune Disorders Drug Targets
#30
JOURNAL ARTICLE
Mulham Al-Nader, Ulrich Krafft, Jochen Hess, Claudia Kesch, Mostafa AbdelRazek, Ahmad Abolyosr, Gamal A Alsagheer, Omar Mohamed, Atef Fathi, Stephan Tschirdewahn, Boris A Hadaschik, Osama Mahmoud
AIM OF THE STUDY: The aim of our study is to evaluate the difference in stricture rate between matched groups of Bricker and Wallace techniques for ureteroileal anastomosis. PATIENTS AND METHODS: A retrospective analysis of patients undergoing urinary diversion (UD) with Bricker and Wallace ureteroileal anastomosis at two university hospitals. Two groups of Bricker and Wallace patients were matched in a 1:1 ratio based on the age, sex, body mass index (BMI), Charlson comorbidity index (CCI), preoperative hydronephrosis, prior radiation therapy or abdominal surgery, pathologic T and N stages and 30-days-Clavien grade complications≥III...
April 21, 2024: International Journal of Urology: Official Journal of the Japanese Urological Association
#31
JOURNAL ARTICLE
Chibuzo Ilonze, Parul Rai, Najibah Galadanci, Rima Zahr, Victoria I Okhomina, Guolian Kang, Dakshin Padmanabhan, Jeffrey Lebensburger, Ammar Saadoon Alishlash
BACKGROUND: Tricuspid regurgitation velocity (TRV), measured by echocardiography, is a surrogate marker for pulmonary hypertension. Limited pediatric studies have considered the association between TRV and surrogate markers of end-organ disease. METHODS: We conducted a cross-sectional study that evaluated the prevalence of elevated TRV ≥2.5 m/s and its associations with renal and cerebrovascular outcomes in children with sickle cell disease (SCD) 1-21 years of age in two large sickle cell cohorts, the University of Alabama at Birmingham (UAB) sickle cell cohort, and the Sickle Cell Clinical Research and Intervention Program (SCCRIP) cohort at St...
April 21, 2024: Pediatric Blood & Cancer
#32
JOURNAL ARTICLE
Jin Hwa Kim, Young Sang Lyu, BongSeong Kim, Mee Kyung Kim, Sang Yong Kim, Ki-Hyun Baek, Ki-Ho Song, Kyungdo Han, Hyuk-Sang Kwon
AIMS: To evaluate the effects of initiating sodium-glucose cotransporter-2 (SGLT2) inhibitors on cardiorenal outcomes and mortality compared to dipeptidyl peptidase-4 (DPP-4) inhibitors as active comparators in patients diagnosed with type 2 diabetes with a history of percutaneous coronary intervention (PCI). MATERIALS AND METHODS: We used an active-comparator, new-user design and nationwide data from the National Health Insurance Service in South Korea from 2014 to 2019...
April 21, 2024: Diabetes, Obesity & Metabolism
#33
REVIEW
Eikan Mishima
Ferroptosis is a type of regulated cell death hallmarked by iron-mediated excessive lipid oxidation. Over the past decade since the coining of the term ferroptosis, advances in research have led to the identification of intracellular processes that regulate ferroptosis such as GSH-GPX4 pathway and FSP1-coenzyme Q10 /vitamin K pathway. From a disease perspective, the involvement of ferroptosis in pathological conditions including kidney disease has attracted attention. In terms of renal pathophysiology, ferroptosis has been widely investigated for its involvement in ischemia-reperfusion injury, nephrotoxin-induced kidney damage and other renal diseases...
April 22, 2024: Clinical and Experimental Nephrology
#34
REVIEW
Clara Cerrato, Fabio Crocerossa, Michele Marchioni, Gianluca Giannarini, Shilpa Gupta, Laurence Albiges, Oscar Brouwer, Maarten Albersen, Christian Fankhauser, Marc Oliver Grimm, Giorgio Gandaglia, Morgan Roupret, Maria Carmen Mir
BACKGROUND AND OBJECTIVE: Immune checkpoint inhibitors (ICIs) and antibody-drug conjugates (ADCs) herald a transformative era in metastatic renal cell carcinoma (RCC) and transitional cell carcinoma (TCC) treatment, amid acknowledged sex-based disparities in these cancers. We conducted a systematic review and network meta-analysis (NMA) to identify sex-specific differences in the efficacy of ICI/ADC monotherapy or combination therapies for RCC and TCC survival, in metastatic and adjuvant settings...
April 20, 2024: European Urology Oncology
#35
JOURNAL ARTICLE
Mehrnoush Hassas Yeganeh, Reza Sinaei, Mitra Rouhi, Reza Shiari, Vadood Javadi Parvaneh, Khosro Rahmani, Erfan Sheikhbahaei
INTRODUCTION AND OBJECTIVES: Henoch Schönlein purpura (HSP) and Kawasaki disease (KD) are two main inflammatory diseases among childhood vasculitis. Considering the anti-inflammatory effects of 25-hydroxyvitamin D3, we decided to investigate the association of serum 25-hydroxy vitamin D3 level with the type and severity of these conditions. MATERIALS AND METHODS: The present study was performed as a historical cohort of 254 affected children with KD and HSP vasculitis...
April 2024: Reumatología clinica
#36
JOURNAL ARTICLE
Zhi Yu, Caina Nian, Wenmei Sun, Xinhua Liu, Xueyuan Nian
BACKGROUND: Human epididymis protein 4 (HE4) has been identified as a biomarker for renal fibrosis. This study aimed to evaluate the role of HE4 in the diagnosis and determination of disease severity and hepatic fibrosis in autoimmune hepatitis (AIH). METHODS: Serum HE4 levels were determined via electrochemiluminescence immunoassays in 60 healthy controls and 109 AIH patients (43 without liver cirrhosis and 66 with liver cirrhosis). Liver biopsy was performed on 56 of 109 enrolled patients...
April 19, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
#37
JOURNAL ARTICLE
Inki Moon, Su Yeong Park, Dongon Kim, Minae Park, Sojeong Park, Seong Soon Kwon, Min Gyu Kong, Hyun Woo Park, Hyung Oh Choi, Jon Suh, Yoon Haeng Cho, Nae Hee Lee, Hye-Sun Seo
BACKGROUND: Regarding the pathophysiology of renal infarction (RI), cardioembolic causes could have large proportion. However, there are notable variations in prevalence of atrial fibrillation (AF) among patients with RI across different studies, ranging from 17 to 65%. The primary objective of this study is to analyze the incidence of AF in patients with RI. METHODS: This nationwide retrospective cohort study enrolled 5200 patients with RI from the Korean National Institute of Health Services database spanning the years 2013 to 2019...
April 19, 2024: International Journal of Cardiology
#38
JOURNAL ARTICLE
Edwin Castillo Velarde, Jorge Roca-Sánchez-Moreno, Alison Núñez Muñoz, Alessandra Guillen Rivera, Mary Hidalgo Babilonia, Jherson García Meneses, Lisseth Mamani Turpo, Willian Cepeda Horna
INTRODUCTION: The effect of clothing on the recording of blood pressure in a normotensive and hypertensive population remains essential remains to diagnosing and managing. METHODS: This is a cross-sectional study to measure blood pressure using a validated oscillometric sphygmomanometer in two populations. The records were made over the thicker sleeve arm and non-sleeved arm (either on bare arm or indicating the removal of the outermost garment). Clothing was categorized according to how patients attended the outpatient clinic based on the real world...
April 20, 2024: Kidney & Blood Pressure Research
#39
JOURNAL ARTICLE
R Rajasekar, R Nandakumar, Saurav P Singhvi, Gerry George Mathew, V Jayaprakash, K Mythili
A 66-year-old non-smoker presented with a 2-week history of new-onset pedal oedema and gross haematuria. On evaluation, he was found to be hypertensive and oedematous with a haemoglobin of 19.1 g/dl, platelet count of 546,000/mm3 , and creatinine of 2.6 mg/dl. Urine examination revealed abundant RBCs with 3+ albumin on three separate occasions. His 24-h urine protein level was 3830 mg/day, with a serum cholesterol level of 303 mg/dl. Secondary erythrocytosis and thrombocytosis tests were negative...
April 21, 2024: CEN Case Reports
#40
EDITORIAL
Giorgina Barbara Piccoli
No abstract text is available yet for this article.
April 20, 2024: Journal of Nephrology
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