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https://www.readbyqxmd.com/read/27820705/use-of-stress-tests-in-evaluating-kidney-disease
#1
Jay L Koyner, Lakhmir S Chawla
PURPOSE OF REVIEW: The kidney, like most other organs, has a reserve capacity that can be utilized in times of increased physiologic demand. The ability to quantify this renal reserve function across various parts of the nephron (glomerular and tubular) has been an area of increased investigation over the past several years. In this review, we discuss several techniques that have been developed to interrogate the maximal physiologic capacity of the injured kidney. RECENT FINDINGS: Although protein loading has been established as an ideal method to investigate glomerular filtration capacity in healthy kidneys, other methods such as the antagonism of the renin-angiotensin-aldosterone system have demonstrated promise as a method to determine underlying glomerular disease in those with acute kidney injury and other comorbidities (e...
January 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/27636110/a-mouse-model-of-furosemide-induced-overactive-bladder
#2
Michael S Saporito, Eva Zuvich, Amy DiCamillo
Detailed in this unit is a mouse model of overactive bladder and urinary incontinence based on diuretic stress-induced urination. The procedure involves the use of a unique, highly sensitive, and automated urine capturing method to measure urinary latency, frequency, and void volume. Although this method was first described and validated using an anti-muscarinic drug used for treating overactive bladder, subsequent work has shown that effective non-cholinergic agents can be detected. These findings indicate good predictive value for this model regarding the possible clinical utility of test agents as treatments for overactive bladder, regardless of their site of action...
2016: Current Protocols in Pharmacology
https://www.readbyqxmd.com/read/27346069/benefit-of-f-15-protocols-in-equivocal-f%C3%A2-%C3%A2-20-mag3-renography-in-children-with-upper-tract-dilatation-and-symmetric-split-function-results-and-outcomes
#3
C Strasser, B Haid, W Langsteger, J Oswald
PURPOSE: In children with upper tract dilatation, diuretic renography, which includes application of mercaptoacetyltriglicin-99 mTc (MAG3), is the standard examination. Ordinarily, furosemide is applied 20 min after tracer injection (F + 20). In children with persistent hydronephrosis and preserved split function, this protocol may lead to further examinations with repeatedly equivocal washout curves. The present study evaluated the potential of MAG3 (F-15) scans in this subgroup of children to achieve a conclusive result avoiding additional equivocal MAG3 (F + 20) scans...
June 3, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27113693/risk-stratification-for-acute-kidney-injury-are-biomarkers-enough
#4
REVIEW
Blaithin A McMahon, Jay L Koyner
Acute kidney injury (AKI) is a common and serious complication that is associated with several adverse outcomes in hospitalized patients. AKI significantly increases the risk of mortality, need for renal replacement therapy, and intensive care admission, and it also has serious economic ramifications. Effective risk stratification to identify patients at risk for severe AKI is essential for targeting our health care and research resources to tackle this important public health issue. The overwhelming majority of research in earlier diagnosis and risk stratification of AKI over the past 10 years has focused on novel biomarker development...
May 2016: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/26982240/hearing-reactive-metabolite-formation-and-oxidative-stress-in-cochleae-after-a-single-acute-overdose-of-acetaminophen-an-in-vivo-study
#5
Mitchell R McGill, Stefanie Kennon-McGill, Dianne Durham, Hartmut Jaeschke
CONTEXT: Although the liver is the primary target organ in acetaminophen (APAP) toxicity, other organs are affected. Previous data suggested that chronic APAP abuse can be ototoxic and the mechanism involves APAP-induced oxidative stress and reactive metabolite (N-acetyl-p-benzoquinone imine, NAPQI)-induced endoplasmic reticulum stress. However, the effect of a single acute overdose on hearing has not been tested. OBJECTIVES: To determine if a single acute APAP overdose causes hearing damage, and to explore possible mechanisms of APAP ototoxicity...
February 2016: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/26438067/hypovolemic-men-and-women-regulate-blood-pressure-differently-following-exposure-to-artificial-gravity
#6
Joyce M Evans, L Christine Ribeiro, Fritz B Moore, Siqi Wang, Qingguang Zhang, Vladimir Kostas, Connor R Ferguson, Jorge Serrador, Michael Falvo, Michael B Stenger, Nandu Goswami, Jon C Rask, Jeffrey D Smith, Charles F Knapp
PURPOSE: In addition to serious bone, vestibular, and muscle deterioration, space flight leads to cardiovascular dysfunction upon return to gravity. In seeking a countermeasure to space flight-induced orthostatic intolerance, we previously determined that exposure to artificial gravity (AG) training in a centrifuge improved orthostatic tolerance of ambulatory subjects. This protocol was more effective in men than women and more effective when subjects exercised. METHODS: We now determine the orthostatic tolerance limit (OTL) of cardiovascularly deconditioned (furosemide) men and women on one day following 90 min of AG compared to a control day (90 min of head-down bed rest, HDBR)...
December 2015: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/26433651/diuretic-and-antioxidant-activities-of-the-aqueous-extract-of-leaves-of-cassia-occidentalis-linn-in-rats
#7
Fidèle Ntchapda, Joseph Barama, David Romain Kemeta Azambou, Paul Faustin Seke Etet, Théophile Dimo
OBJECTIVE: To assess the putative diuretic and antioxidant properties of Cassia occidentalis (C. occidentalis) leaves' aqueous extract. METHODS: Adult rats were administered with C. occidentalis leaves aqueous extract acutely (24 h) and subchronically (7 d), at doses 80, 160, 240, 320, and 400 mg/kg (per os). Negative control group received only an equivalent volume of distilled water, while the two positive control groups received the diuretic drugs furosemide (20 mg/kg, ip...
September 2015: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/26069915/-three-shades-of-fluids-bergstr%C3%A3-m-2-0%C3%A2-%C3%A2-furosemide-stress-test%C3%A2-%C3%A2-replacement-fluid-for-therapeutic-plasma-exchange
#8
Julius J Schmidt, Jan T Kielstein
Fluids play an important role in clinical nephrology.1) Temperature of dialysate fluid has recently re-attracted a lot of attention. Individualized cooling of the dialysate (0.5 °C below predialysis ear temperature) has been shown to not only prevent intradialytic hypotension but also to improve myocardial contractility and to prevent white matter changes in CKD5D.2) Access fluid in AKI is associated with an increased mortality. While Furosemide has no place in treating AKI the Furosemide stress test can help to identify patients with AKI that will eventually need renal replacement therapy...
June 2015: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/26029729/ototoxicity-induced-loss-of-hearing-and-inner-hair-cells-is-attenuated-by-hsp70-gene-transfer
#9
Yohei Takada, Tomoko Takada, Min Young Lee, Donald L Swiderski, Lisa L Kabara, David F Dolan, Yehoash Raphael
The most common reason for sensorineural deafness is death of hair cells (HCs). Heat shock proteins (HSPs) are molecular chaperones that participate in folding, targeting, and degrading proteins. HSP expression is increased in response to various environmental stresses to protect cells from damage. Here, we tested whether viral-mediated overexpression of HSP70 can protect HCs and hearing from severe ototoxicity (kanamycin and furosemide) in guinea pigs. Adenovirus-HSP70 mCherry (Ad.HSP70-mCherry) was injected to experimental animals and adenovirus-mCherry to controls, 4 days before the ototoxic insult...
2015: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/25655066/the-furosemide-stress-test-and-predicting-aki-outcomes
#10
EDITORIAL
T Clark Powell, David G Warnock
No abstract text is available yet for this article.
August 2015: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/25655065/furosemide-stress-test-and-biomarkers-for-the-prediction-of-aki-severity
#11
COMPARATIVE STUDY
Jay L Koyner, Danielle L Davison, Ermira Brasha-Mitchell, Divya M Chalikonda, John M Arthur, Andrew D Shaw, James A Tumlin, Sharon A Trevino, Michael R Bennett, Paul L Kimmel, Michael G Seneff, Lakhmir S Chawla
Clinicians have access to limited tools that predict which patients with early AKI will progress to more severe stages. In early AKI, urine output after a furosemide stress test (FST), which involves intravenous administration of furosemide (1.0 or 1.5 mg/kg), can predict the development of stage 3 AKI. We measured several AKI biomarkers in our previously published cohort of 77 patients with early AKI who received an FST and evaluated the ability of FST urine output and biomarkers to predict the development of stage 3 AKI (n=25 [32...
August 2015: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/25604076/investigating-the-stress-attenuating-potential-of-furosemide-in-immobilization-and-electric-foot-shock-stress-models-in-mice
#12
Aalamjeet Kaur, Anjana Bali, Nirmal Singh, Amteshwar Singh Jaggi
The present study was designed to investigate the antistress effect of furosemide (sodium potassium chloride co-transporter inhibitor) in immobilization and foot-shock stress-induced behavioral alterations in the mice. Acute stress was induced in Swiss albino mice either by applying electric foot shocks of 0.6-mA intensity of 1-s duration with 30-s inter-shock interval for 1 h or immobilizing for 150 min. The acute stress-induced behavioral changes were assessed by using actophotometer, hole board, open-field, and social interaction tests...
May 2015: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/24754201/simulations-of-gravitational-stress-on-normovolemic-and-hypovolemic-men-and-women
#13
Qingguang Zhang, Charles F Knapp, Michael B Stenger, Abhijit R Patwardhan, Samy C Elayi, Siqi Wang, Vladimir I Kostas, Joyce M Evans
BACKGROUND: Earth-based simulations of physiologic responses to space mission activities are needed to develop prospective countermeasures. To determine whether upright lower body positive pressure (LBPP) provides a suitable space mission simulation, we investigated the cardiovascular responses of normovolemic and hypovolemic men and women to supine and orthostatic stress induced by head-up tilt (HUT) and upright LBPP, representing standing in lunar, Martian, and Earth gravities. METHODS: Six men and six women were tested in normovolemic and hypovolemic (furosemide, intravenous, 0...
April 2014: Aviation, Space, and Environmental Medicine
https://www.readbyqxmd.com/read/24053972/development-and-standardization-of-a-furosemide-stress-test-to-predict-the-severity-of-acute-kidney-injury
#14
MULTICENTER STUDY
Lakhmir S Chawla, Danielle L Davison, Ermira Brasha-Mitchell, Jay L Koyner, John M Arthur, Andrew D Shaw, James A Tumlin, Sharon A Trevino, Paul L Kimmel, Michael G Seneff
INTRODUCTION: In the setting of early acute kidney injury (AKI), no test has been shown to definitively predict the progression to more severe stages. METHODS: We investigated the ability of a furosemide stress test (FST) (one-time dose of 1.0 or 1.5 mg/kg depending on prior furosemide-exposure) to predict the development of AKIN Stage-III in 2 cohorts of critically ill subjects with early AKI. Cohort 1 was a retrospective cohort who received a FST in the setting of AKI in critically ill patients as part of Southern AKI Network...
September 20, 2013: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/23844014/mesenchymal-stem-cells-improve-medullary-inflammation-and-fibrosis-after-revascularization-of-swine-atherosclerotic-renal-artery-stenosis
#15
Behzad Ebrahimi, Alfonso Eirin, Zilun Li, Xiang-Yang Zhu, Xin Zhang, Amir Lerman, Stephen C Textor, Lilach O Lerman
Atherosclerotic renal artery stenosis (ARAS) raises blood pressure and can reduce kidney function. Revascularization of the stenotic renal artery alone does not restore renal medullary structure and function. This study tested the hypothesis that addition of mesenchymal stem cells (MSC) to percutaneous transluminal renal angioplasty (PTRA) can restore stenotic-kidney medullary tubular transport function and attenuate its remodeling. Twenty-seven swine were divided into three ARAS (high-cholesterol diet and renal artery stenosis) and a normal control group...
2013: PloS One
https://www.readbyqxmd.com/read/23333517/effects-of-short-term-exposure-to-environmentally-relevant-concentrations-of-different-pharmaceutical-mixtures-on-the-immune-response-of-the-pond-snail-lymnaea-stagnalis
#16
M Gust, M Fortier, J Garric, M Fournier, F Gagné
Pharmaceuticals are pollutants of potential concern in the aquatic environment where they are commonly introduced as complex mixtures via municipal effluents. Many reports underline the effects of pharmaceuticals on immune system of non target species. Four drug mixtures were tested, and regrouped pharmaceuticals by main therapeutic use: psychiatric (venlafaxine, carbamazepine, diazepam), antibiotic (ciprofloxacine, erythromycin, novobiocin, oxytetracycline, sulfamethoxazole, trimethoprim), hypolipemic (atorvastatin, gemfibrozil, benzafibrate) and antihypertensive (atenolol, furosemide, hydrochlorothiazide, lisinopril)...
February 15, 2013: Science of the Total Environment
https://www.readbyqxmd.com/read/22748734/ingestive-behavior-in-rat-pups-is-modified-by-maternal-sodium-depletion
#17
COMPARATIVE STUDY
Carmen Perillán, Paula Núñez, Marina Costales, Manuel Vijande, Juan Argüelles
Developmental programming by maternal stress during pregnancy is found to influence behavioral development in the offspring. The main objective of this study was to investigate the effect of maternal sodium depletion in rats during pregnancy on the development of thirst mechanisms in the offspring. Pregnant rats underwent 3 episodes of saline depletion, induced by injecting sc 10 mg of Furosemide in saline (0.5 ml). The treatment, given on the 14th, 17th and 20th days post-conception, is thought to induce acute sodium depletion on dams...
2012: Psicothema
https://www.readbyqxmd.com/read/22130642/association-of-filtered-sodium-load-with-medullary-volumes-and-medullary-hypoxia-in-hypertensive-african-americans-as-compared-with-whites
#18
COMPARATIVE STUDY
Stephen C Textor, Monika L Gloviczki, Michael F Flessner, David A Calhoun, James Glockner, Joseph P Grande, Michael A McKusick, Stephen S Cha, Lilach O Lerman
BACKGROUND: African Americans develop hypertension earlier with more target manifestations than whites despite having a higher glomerular filtration rate (GFR) for any level of serum creatinine. STUDY DESIGN & PARTICIPANTS: This study tested the hypothesis that increased GFR and sodium reabsorption in African Americans is associated with increased metabolic work and medullary hypoxia in 49 nondiabetic patients with essential hypertension (29 whites and 20 African Americans) following a constant-sodium diet (150 mEq/d) and renin-angiotensin system blockade...
February 2012: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/21775485/increased-glomerular-filtration-rate-in-early-metabolic-syndrome-is-associated-with-renal-adiposity-and-microvascular-proliferation
#19
Zilun Li, John R Woollard, Shenming Wang, Michael J Korsmo, Behzad Ebrahimi, Joseph P Grande, Stephen C Textor, Amir Lerman, Lilach O Lerman
Metabolic syndrome (MetS) is associated with glomerular hyperfiltration and is a risk factor for chronic kidney disease, but the underlying mechanisms are poorly defined. This study tested the hypothesis that increased glomerular filtration rate (GFR) in early MetS is associated with renal adiposity and microvascular proliferation. Twelve MetS-prone Ossabaw pigs were randomized to 10 wk of a standard (lean, n = 6) or atherogenic (MetS, n = 6) diet. Kidney hemodynamics and function, perirenal fat volume, and tubular dynamics were assessed in vivo by multidetector computed tomography (CT) and blood oxygen level-dependent (BOLD)-MRI...
November 2011: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/20861077/8-iso-prostaglandin-f2%C3%AE-stimulates-chloride-transport-in-thick-ascending-limbs-role-of-camp-and-protein-kinase-a
#20
Pablo D Cabral, Guillermo B Silva, Sandra T Baigorria, Luis A Juncos, Luis I Juncos, Néstor H García
Salt reabsorption by the loop of Henle controls NaCl handling and blood pressure regulation. Increased oxidative stress stimulates NaCl transport in one specific segment of the loop of Henle called the thick ascending limb (TAL). The isoprostane 8-iso-prostaglandin-F2α (8-iso-PGF2α) is one of the most abundant nonenzymatic lipid oxidation products and has been implicated in the development of hypertension. However, it is not known whether 8-iso-PGF2α regulates transport or the mechanisms involved. Because protein kinase A (PKA) stimulates NaCl transport in several nephron segments, we hypothesized that 8-iso-PGF2α increases NaCl transport in the cortical TAL (cTAL) via a PKA-dependent mechanism...
December 2010: American Journal of Physiology. Renal Physiology
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