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https://www.readbyqxmd.com/read/27922889/pump-speed-optimization-in-stable-patients-with-a-left-ventricular-assist-device
#1
Lotte E Couperus, Victoria Delgado, Mand J H Khidir, Marijke P M Vester, Meindert Palmen, Marta Fiocco, Eduard R Holman, Laurens F Tops, Robert J M Klautz, Harriëtte F Verwey, Martin J Schalij, Saskia L M A Beeres
Optimal left ventricular assist device (LVAD) functioning and preservation of right ventricular (RV) function are major survival determinants in destination therapy (DT)-LVAD recipients. Currently, the indication for routine pump speed optimization in stable patients and its effect on RV function at follow-up remain underexplored. Hemodynamically stable patients (N=17, age 61 [interquartile range {IQR} 51-66]years; 13 [77%] male) underwent a routine speed ramp test. Echocardiographic images were obtained at incremental speed settings to determine optimal pump speed...
December 2, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27919886/cardiopulmonary-exercise-testing-in-children-with-cystic-fibrosis-one-centre-s-experience
#2
Elise Weir, Paul D Burns, Anne Devenny, David Young, James Y Paton
BACKGROUND: While exercise testing is increasingly used as a prognostic indicator in cystic fibrosis (CF), it is reported to be underused in UK CF centres, particularly in children. Here, we evaluated the cardiopulmonary exercise testing (CPET) results in children and young people with CF at CF annual review and its possible clinical value. METHOD: An observational study comparing CPET results using a cycle ergometer ramp test (peak oxygen uptake (Vo2peak)) and pulmonary function (forced expiratory volume in 1 s (FEV1)) was performed with body mass index (BMI) used as a disease severity marker...
December 5, 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27919636/adrenomedullin-and-angiotensin-ii-signaling-pathways-involved-in-the-effects-on-cerebellar-antioxidant-enzymes-activity
#3
Figueira Leticia, Israel Anita
Human adrenomedullin (AM) is a 52-amino acid peptide involved in cardiovascular control. AM has two specific receptors formed by the calcitonin-receptor-like receptor (CRLR) and receptor activity-modifying protein (RAMP) 2 or 3, known as AM1 and AM2 receptors, respectively. In addition, AM has appreciable affinity for the calcitonin gene-1 related peptide receptor (CGRP1), composed of CRLR/RAMP1. In brain, AM and their receptors are expressed in several localized areas, including the cerebellum. AM has been reported as an antioxidant...
December 2, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27917151/impairment-of-smooth-pursuit-as-a-marker-of-early-multiple-sclerosis
#4
Nathaniel Lizak, Meaghan Clough, Lynette Millist, Tomas Kalincik, Owen B White, Joanne Fielding
BACKGROUND: Multiple sclerosis (MS) is a diffuse disease that disrupts wide-ranging cerebral networks. The control of saccades and smooth pursuit are similarly dependent upon widespread networks, with the assessment of pursuit offering an opportunity to examine feedback regulation. We sought to characterize pursuit deficits in MS and to examine their relationship with disease duration. METHODS: Twenty healthy controls, 20 patients with a clinically isolated syndrome (CIS), and 40 patients with clinically definite MS (CDMS) participated...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27910476/operation-results-of-the-kstar-far-infrared-interferometer
#5
June-Woo Juhn, K C Lee, H M Wi, Y S Kim, Y U Nam
The 2015 KSTAR experimental campaign was the first year of routine measurement with a far infrared interferometer (FIRI) utilizing 118.87 μm CH3OH lasers at maximum 200 mW CW beam power. By using rtEFIT reconstruction, the path lengths of interferometers can be calculated and so the line-averaged electron densities n¯e from the FIRI and a millimeter-wave interferometer were in excellent agreement. In this way, the number of successfully diagnosed discharges is counted: 1003 shots or 83.7% of sustained discharges, defined as shots of plasma current IP ≥ 0...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910316/measurement-of-the-deuterium-balmer-series-line-emission-on-east
#6
C R Wu, J Huang, W Gao, W Gao, Z Xu, J F Chang, Y M Hou, Z Jin, J C Xu, Y M Duan, P F Zhang, Y J Chen, L Zhang, Z W Wu, J G Li
Volume recombination plays an important role towards plasma detachment for magnetically confined fusion devices. High quantum number states of the Balmer series of deuterium are used to study recombination. On EAST (Experimental Advanced Superconducting Tokamak), two visible spectroscopic measurements are applied for the upper/lower divertor with 13 channels, respectively. Both systems are coupled with Princeton Instruments ProEM EMCCD 1024B camera: one is equipped on an Acton SP2750 spectrometer, which has a high spectral resolution ∼0...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27909360/learning-curves-observed-in-establishing-targeted-rate-of-force-application-in-pressure-pain-algometry
#7
Alicia J Emerson Kavchak, Josiah D Sault, Ann Vendrely
Purpose: To determine whether learning curves can be observed with deliberate practice when the goal is to apply a consistent rate of force at 5 N/second during pressure pain threshold (PPT) testing in healthy volunteers. Methods: In this prospective study, 17 clinician participants completed PPT targeted rate-of-application testing with healthy volunteers using three different feedback paradigms. The resultant performances of ramp rate during 36 trials were plotted on a graph and examined to determine whether learning curves were observed...
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27908147/strategies-for-ct-tissue-segmentation-for-monte-carlo-calculations-in-nuclear-medicine-dosimetry
#8
P E N Braad, T Andersen, S B Hansen, P F Høilund-Carlsen
PURPOSE: CT images are used for patient specific Monte Carlo treatment planning in radionuclide therapy. The authors investigated the impact of tissue classification, CT image segmentation, and CT errors on Monte Carlo calculated absorbed dose estimates in nuclear medicine. METHODS: CT errors as a function of patient size, CT reconstruction, and tube current modulation methods were assessed in a phantom experiment on a clinical CT system. The impact of tissue segmentation methods and CT number variations on EGSnrc Monte Carlo calculated absorbed dose distributions was assessed for (99m)Tc and (131)I in the ICRP/ICRU male phantom and in a patient PET/CT-scanned with (124)I prior to radioiodine therapy...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27899894/moderate-load-eccentric-exercise-a-distinct-novel-training-modality
#9
REVIEW
Hans Hoppeler
Over the last 20 years a number of studies have been published using progressive eccentric exercise protocols on motorized ergometers or similar devices that allow for controlled application of eccentric loads. Exercise protocols ramp eccentric loads over an initial 3 weeks period in order to prevent muscle damage and delayed onset muscle soreness. Final training loads reach 400-500 W in rehabilitative settings and over 1200 W in elite athletes. Training is typically carried out three times per week for durations of 20-30 min...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27884955/effect-of-exercise-induced-muscle-damage-on-vascular-function-and-skeletal-muscle-microvascular-deoxygenation
#10
Jacob T Caldwell, Garrett C Wardlow, Patrece A Branch, Macarena Ramos, Christopher D Black, Carl J Ade
This paper investigated the effects of unaccustomed eccentric exercise-induced muscle damage (EIMD) on macro- and microvascular function. We tested the hypotheses that resting local and systemic endothelial-dependent flow-mediated dilation (FMD) and microvascular reactivity would decrease, V˙O2max would be altered, and that during ramp exercise, peripheral O2 extraction, evaluated via near-infrared-derived spectroscopy (NIRS) derived deoxygenated hemoglobin + myoglobin ([HHb]), would be distorted following EIMD In 13 participants, measurements were performed prior to (Pre) and 48 h after a bout of knee extensor eccentric exercise designed to elicit localized muscle damage (Post)...
November 2016: Physiological Reports
https://www.readbyqxmd.com/read/27878491/possible-cause-of-nonlinear-tension-rise-in-activated-muscle-fiber-during-stretching
#11
P V Kochubei, S Yu Bershitsky
Tension in contracting muscle fiber under conditions of ramp stretching rapidly increases, but after reaching a critical stretch Pc sharply decreases. To find out the cause of these changes in muscle fiber tension, we stopped stretching before and after reaching Pc and left the fiber stretched for 50 msec. After rapid tension drop, the transient tension rise not accompanied by fiber stiffness increase was observed only in fibers heated to 25°C and stretched to Pc. Under other experimental conditions, this growth was absent...
November 22, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27866688/optimal-mixing-rate-in-linear-solvent-strength-gradient-liquid-chromatography-balanced-mixing-program
#12
Leonid M Blumberg, Gert Desmet
The mixing rate (Rϕ) is the temporal rate of increase in the solvent strength in gradient LC. The optimal Rϕ (Rϕ,Opt) is the one at which a required peak capacity of gradient LC analysis is obtained in the shortest time. The balanced mixing program is a one where, for better separation of early eluting solutes, the mixing ramp is preceded by a balanced isocratic hold of the duration depending on Rϕ. The improvement in the separation of the earlier eluites due to the balanced programming has been evaluated...
December 9, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27862051/comparison-of-the-ballistic-contractile-responses-generated-during-microstimulation-of-single-human-motor-axons-with-brief-irregular-and-regular-stimuli
#13
Michael Leitch, Vaughan G Macefield
INTRODUCTION: Ballistic contractions are induced by brief, high frequency (60-100 Hz) trains of action potentials in motor axons. During ramp voluntary contractions, human motoneurones exhibit significant discharge variability of ∼20% and have shown to be advantageous to the neuromuscular system. We hypothesized that ballistic contractions incorporating discharge variability generate greater isometric forces than regular trains with zero variability. METHODS: High impedance tungsten microelectrodes were inserted into the fibular nerve, and single motor axons were stimulated with both irregular and constant-frequency stimuli at mean frequencies ranging from 57...
November 11, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27861471/-comparison-of-peak-oxygen-uptake-and-ve-vco2-slope-between-children-with-and-without-heart-failure
#14
Hermes Ilarraza-Lomelí, Irma Miranda Chávez, Javier Castañeda-López, Rafael Chávez-Domínguez, Carlos Felipe Barrera-Ramírez, Marianna García-Saldivia, María Dolores Rius-Suárez, Alfonso Buendía-Hernández
: Heart failure is a health problem associated with disability and mortality. Physicians may stratify the risk of adult patients with heart failure using a cardiopulmonary exercise testing. Until now, in childhood this evaluation has been poorly used. The purpose of this study is to compare the peak oxygen uptake and minute ventilation/carbon dioxide production slope among children with heart failure versus children without heart disease (control). METHODS: Thirty-eight children with heart failure were compared with 194 children without heart disease...
November 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27861244/effects-of-risk-assessment-and-management-programme-for-hypertension-on-clinical-outcomes-and-cardiovascular-disease-risks-after-12-months-a-population-based-matched-cohort-study
#15
Esther Y T Yu, Eric Y F Wan, Carlos K H Wong, Anca K C Chan, Karina H Y Chan, Sin-Yi Ho, Ruby L P Kwok, Cindy L K Lam
OBJECTIVES: This study evaluated the effectiveness of a structured multidisciplinary risk assessment and management programme for patients with hypertension (RAMP-HT) who were managed in public primary care clinics but had suboptimal blood pressure (BP) control in improving BP, LDL-cholesterol (LDL-C) and predicted 10-year cardiovascular disease (CVD) risk after 12 months of intervention. METHODS: A total of 10 262 hypertension patients with suboptimal BP despite treatment, aged less than 80 years and without existing CVD were enrolled in RAMP-HT between October 2011 and March 2012 from public general out-patient clinics in Hong Kong...
November 16, 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27859472/effect-of-ketoconazole-a-strong-cyp3a-inhibitor-on-the-pharmacokinetics-of-venetoclax-a-bcl-2-inhibitor-in-patients-with-non-hodgkin-lymphoma
#16
Suresh K Agarwal, Ahmed Hamed Salem, Alexey V Danilov, Beibei Hu, Soham Puvvada, Martin Gutierrez, David Chien, Lionel D Lewis, Shekman L Wong
AIM: To examine the effect of a strong CYP3A inhibitor, ketoconazole, on the pharmacokinetics, safety, and tolerability of venetoclax. METHODS: Twelve patients with Non-Hodgkin lymphoma (NHL) were enrolled in this Phase 1, open-label, fixed-sequence study. Patients received a single 50 mg dose of venetoclax orally on Day 1 and Day 8, and a 400 mg once daily dose of ketoconazole on Days 5 through 11. Blood samples were collected predose and up to 96 hours after each venetoclax dose on Day 1 and Day 8...
November 2, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27848048/role-of-radical-antegrade-modular-pancreatosplenectomy-ramps-and-pancreatic-cancer
#17
Yun Shin Chun
PURPOSE: Conventional retrograde distal pancreatectomy and splenectomy for pancreatic adenocarcinoma of the body and tail have been associated with high rates of positive margins, low lymph node retrieval, and poor overall survival. Radical antegrade modular pancreatosplenectomy (RAMPS) was introduced in 2003 to overcome these limitations. METHODS: A systematic literature search was performed and articles reviewed to determine if RAMPS or standard distal pancreatectomy and splenectomy offer better survival...
November 15, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27847474/reward-anticipation-dynamics-during-cognitive-control-and-episodic-encoding-implications-for-dopamine
#18
Kimberly S Chiew, Jessica K Stanek, R Alison Adcock
Dopamine (DA) modulatory activity critically supports motivated behavior. This modulation operates at multiple timescales, but the functional roles of these distinct dynamics on cognition are still being characterized. Reward processing has been robustly linked to DA activity; thus, examining behavioral effects of reward anticipation at different timing intervals, corresponding to different putative dopaminergic dynamics, may help in characterizing the functional role of these dynamics. Towards this end, we present two research studies investigating reward motivation effects on cognitive control and episodic memory, converging in their manipulation of rapid vs...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27843407/flux-avalanche-in-a-superconducting-film-with-non-uniform-critical-current-density
#19
Yurong Lu, Ze Jing, Huadong Yong, Youhe Zhou
The flux avalanche in type-II superconducting thin film is numerically simulated in this paper. We mainly consider the effect of non-uniform critical current density on the thermomagnetic stability. The nonlinear electromagnetic constitutive relation of the superconductor is adopted. Then, Maxwell's equations and heat diffusion equation are numerically solved by the fast Fourier transform technique. We find that the non-uniform critical current density can remarkably affect the behaviour of the flux avalanche...
October 2016: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/27836428/high-speed-imaging-of-vocal-fold-vibration-onset-delay-normal-versus-abnormal
#20
Peak Woo
OBJECTIVES: Vocal fold vibration onset delay (VFVOD) is heard frequently in spasmodic dysphonia and in muscle tension dysphonia. VFVOD changes due to other vocal pathologies have not been investigated. VFVOD during sustained vowel production was estimated with high-speed video in 10 normal and 40 pathologic subjects (scars, vocal fold paralysis, vocal fold nodules, and polyps). Analysis of high-speed video was done using digital kymography. RESULTS: VFVOD can be divided into two portions...
November 8, 2016: Journal of Voice: Official Journal of the Voice Foundation
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