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https://www.readbyqxmd.com/read/29334615/hemodynamic-and-metabolic-responses-to-self-paced-and-ramp-graded-exercise-testing-protocols
#1
Nicholas M Beltz, Fabiano Amorim, Ann L Gibson, Jeffrey M Janot, Len Kravitz, Christine M Mermier, Nathan Cole, Terence A Moriarty, Tony P Nunez, Sam Trigg, Lance Dalleck
PURPOSE: Recent examinations have shown lower maximal oxygen uptake (VO2max) during traditional ramp (RAMP) compared to self-paced (SPV) graded exercise testing (GXT) attributed to differences in cardiac ouput. The current study examined the differences in hemodyamic and metabolic responses between RAMP and SPV during treadmill exercise. METHODS: Sixteen recreationally trained men (23.7±3.0 yrs) completed two separate treadmill GXT protocols. SPV consisted of five 2-min stages (10 min total) of increasing speed clamped by the Borg RPE6-20 scale...
January 15, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29334345/arm-crank-ergometry-improves-cardiovascular-disease-risk-factors-and-community-mobility-independent-of-body-composition-in-high-motor-complete-spinal-cord-injury
#2
James J Bresnahan, Gary J Farkas, Jody L Clasey, James W Yates, David R Gater
OBJECTIVE: Evaluate the effect of aerobic exercise using arm crank ergometry (ACE) in high motor complete (ISNCSCI A/B) spinal cord injury (SCI) as primarily related to cardiovascular disease (CVD) risk factors and functional mobility and secondarily to body composition and metabolic profiles. DESIGN: Longitudinal interventional study at an academic medical center. METHODS: Ten previously untrained participants (M8/F2, Age 36.7 y ± 10.1, BMI 24...
January 15, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29331298/spatiotemporal-characterization-of-microdamage-accumulation-in-rat-ulnae-in-response-to-uniaxial-compressive-fatigue-loading
#3
Xuhui Zhang, Xiyu Liu, Zedong Yan, Jing Cai, Fei Kang, Shuai Shan, Pan Wang, Mingming Zhai, X Edward Guo, Erping Luo, Da Jing
Repetitive fatigue loading can induce microdamage accumulation in bone matrix, which results in impaired mechanical properties and increased fracture susceptibility. However, the spatial distribution and time-variant process of microdamage accumulation in fatigue-loaded skeleton, especially for linear microcracks which are known to initiate bone remodeling, remain not fully understood. In this study, the time-varying process of the morphology and distribution of microcracks in rat ulnae subjected to uniaxial compressive fatigue loading was investigated...
January 10, 2018: Bone
https://www.readbyqxmd.com/read/29327012/low-force-spectroscopy-on-graphene-membranes-by-scanning-tunneling-microscopy
#4
Bernd Uder, Haibin Gao, Peter Kunnas, Niels de Jonge, Uwe Hartmann
Two-dimensional atomically flat sheets with a high mechanical flexibility are very attractive as ultrathin membranes but are also inherently challenging for microscopic investigations. We report on a method using Scanning Tunneling Microscopy (STM) under ultra-high vacuum conditions for non-indenting low-force spectroscopy on micrometer-sized freestanding graphene membranes. The method is based on applying quasi-static voltage ramps with active feedback at low tunneling currents and ultimately relies on the attractive electrostatic force between the tip and the membrane...
January 12, 2018: Nanoscale
https://www.readbyqxmd.com/read/29325813/cardiac-function-and-exercise-adaptation-in-8-children-with-lpin1-mutations
#5
Antoine Legendre, Diala Khraiche, Phalla Ou, François-Xavier Mauvais, Marine Madrange, Anne-Sophie Guemann, Jean-Philippe Jais, Damien Bonnet, Yamina Hamel, Pascale de Lonlay
INTRODUCTION: Lipin-1 deficiency is a major cause of rhabdomyolysis that are precipitated by febrile illness. The prognosis is poor, with one-third of patients dying from cardiac arrest during a crisis episode. Apart from acute rhabdomyolysis, most patients are healthy, showing normal clinical and cardiac ultrasound parameters. PATIENTS AND METHODS: We report cardiac and exercise examinations of 8 children carrying two LPIN1 mutations. The examinations were performed outside of a myolysis episode, but one patient presented with fever during one examination...
January 5, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29324983/pulsatile-hemodynamics-are-associated-with-exercise-capacity-in-patients-with-exertional-dyspnea-and-preserved-left-ventricular-ejection-fraction
#6
M Broufa, S Wassertheurer, B Hametner, R Zweiker, R K Binder, T Weber
Background: Pulsatile hemodynamics are associated with left ventricular filling pressures and diastolic dysfunction. We investigated their relationship with maximum workload and peak oxygen uptake (peak VO2) in patients with exertional dyspnea and preserved left ventricular ejection fraction (LVEF). Methods: Radial waveforms from tonometry were processed with a transfer function, pulse wave analysis and wave separation analysis, yielding central aortic pressures and measures of forward (amplitude of forward wave-Pf) and reflected waves (Augmentation Index-AIx, Augmentation Pressure-AP, amplitude of backward wave-Pb) and their ratio (Reflection Magnitude-RM)...
January 9, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29320309/isocapnic-buffering-phase-a-useful-indicator-of-exercise-endurance-and-prognosis-in-patients-with-coronary-artery-disease
#7
Yun-Shan Yen, Daniel Chiung Jui Su, Kuo-Shu Yuan, Po-Wei Chen, Julie Chi Chow, Willy Chou
OBJECTIVES: The significance of the isocapnic buffering (IB) phase - the period between the first ventilatory threshold (1stVT) and respiratory compensation point (RCP) - has not been adequately established in patients. This study aimed to determine the clinical significance of the IB phase in coronary artery disease (CAD) patients. METHODS: This retrospective study included data of sixty-two CAD patients after coronary artery bypass graft (CABG) or percutaneous coronary intervention (PCI) performed in a single medical center between 2010-2014...
January 10, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29317639/tectonically-triggered-sediment-and-carbon-export-to-the-hadal-zone
#8
Rui Bao, Michael Strasser, Ann P McNichol, Negar Haghipour, Cameron McIntyre, Gerold Wefer, Timothy I Eglinton
Sediments in deep ocean trenches may contain crucial information on past earthquake history and constitute important sites of carbon burial. Here we present 14C data on bulk organic carbon (OC) and its thermal decomposition fractions produced by ramped pyrolysis/oxidation for a core retrieved from the >7.5 km-deep Japan Trench. High-resolution 14C measurements, coupled with distinctive thermogram characteristics of OC, reveal hemipelagic sedimentation interrupted by episodic deposition of pre-aged OC in the trench...
January 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29315165/exercise-thresholds-on-trial-are-they-really-equivalent
#9
Kevin Caen, Kobe Vermeire, Jan G Bourgois, Jan Boone
PURPOSE: The interchangeable use of whole-body exercise thresholds and breakpoints (BPs) in the local oxygenation response, as measured via near-infrared spectroscopy (NIRS), has recently been questioned in scientific literature. Therefore, the present study aimed to longitudinally investigate the interrelationship of four commonly used exercise thresholds: critical power (CP), the respiratory compensation point (RCP) and BPs in muscle (m[HHb]BP) and brain (c[O2Hb]BP) oxygenation. METHODS: Nine male participants (21...
January 8, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29310699/planning-a-sports-training-program-using-adaptive-particle-swarm-optimization-with-emphasis-on-physiological-constraints
#10
Nattapon Kumyaito, Preecha Yupapin, Kreangsak Tamee
OBJECTIVE: An effective training plan is an important factor in sports training to enhance athletic performance. A poorly considered training plan may result in injury to the athlete, and overtraining. Good training plans normally require expert input, which may have a cost too great for many athletes, particularly amateur athletes. The objectives of this research were to create a practical cycling training plan that substantially improves athletic performance while satisfying essential physiological constraints...
January 8, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29310347/radical-antegrade-modular-pancreatosplenectomy-for-adenocarcinomaof-the-body-of-the-pancreas-in-a-patient-with-portal-annular-pancreas-aberrant-hepatic-artery-and-absence-of-the-celiac-trunk-a-case-report
#11
Hao Yuan, Pengfei Wu, Jianmin Chen, Zipeng Lu, Lei Chen, Jishu Wei, Feng Guo, Baobao Cai, Jie Yin, Dong Xu, Kuirong Jiang, Yi Miao
RATIONALE: Portal annular pancreas is a rare anatomic variation, where the uncinated process of the pancreas connects with the dorsal pancreas and the pancreas tissue encases the portal vein (PV), superior mesenteric vein (SMV) or splenic vein (SV). Malignancies are quite uncommon in the patients, who have an annular pancreas especially portal annular pancreas. Ectopic common hepatic artery and absence of the celiac trunk (CT) are the other infrequent abnormalities. PATIENT CONCERNS: A 74-year-old man suffered from upper abdominal and back pain...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29306762/microfluidic-platform-for-single-cell-analysis-under-dynamic-spatial-and-temporal-stimulation
#12
Jiyoung Song, Hyunryul Ryu, Minhwan Chung, Youngtaek Kim, Yannick Blum, Sung Sik Lee, Olivier Pertz, Noo Li Jeon
Recent research on cellular responses is shifting from static observations recorded under static stimuli to real-time monitoring in a dynamic environment. Since cells sense and interact with their surrounding microenvironment, an experimental platform where dynamically changing cellular microenvironments should be recreated in vitro. There has been a lack of microfluidic devices to support spatial and temporal stimulations in a simple and robust manner. Here, we describe a microfluidic device that generates dynamic chemical gradients and pulses in both space and time using a single device...
December 27, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29306686/application-of-fractal-theory-for-crash-rate-prediction-insights-from-random-parameters-and-latent-class-tobit-models
#13
Sai Chand, Vinayak V Dixit
The repercussions from congestion and accidents on major highways can have significant negative impacts on the economy and environment. It is a primary objective of transport authorities to minimize the likelihood of these phenomena taking place, to improve safety and overall network performance. In this study, we use the Hurst Exponent metric from Fractal Theory, as a congestion indicator for crash-rate modeling. We analyze one month of traffic speed data at several monitor sites along the M4 motorway in Sydney, Australia and assess congestion patterns with the Hurst Exponent of speed (Hspeed)...
January 4, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29305938/ca2-dependent-potassium-channels-and-cannabinoid-signaling-in-the-endothelium-of-apolipoprotein-e-knockout-mice-before-plaque-formation
#14
Alexander I Bondarenko, Olga Panasiuk, Iryna Okhai, Fabrizio Montecucco, Karim J Brandt, François Mach
Endothelial Ca2+-dependent K+ channels (KCa) regulate endothelial function. We also know that stimulation of type 2 cannabinoid (CB2) receptors ameliorates atherosclerosis. However, whether atherosclerosis is accompanied by altered endothelial KCa- and CB2 receptor-dependent signaling is unknown. By utilizing an in situ patch-clamp approach, we directly evaluated the KCa channel function and the CB2 receptor-dependent electrical responses in the endothelium of aortic strips from young ApoE-/- and C57Bl/6 mice...
January 3, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29305552/venetoclax-for-patients-with-chronic-lymphocytic-leukemia-who-progressed-during-or-after-idelalisib-therapy
#15
Steven Coutre, Michael Choi, Richard R Furman, Herbert Eradat, Leonard Heffner, Jeffrey A Jones, Brenda Chyla, Lang Zhou, Suresh Agarwal, Tina Waskiewicz, Maria Verdugo, Rod A Humerickhouse, Jalaja Potluri, William G Wierda, Matthew S Davids
B-cell receptor pathway inhibitors (BCRi) have transformed treatment for chronic lymphocytic leukemia (CLL); however, efficacy of therapies for patients whose disease is refractory to/relapses after (R/R) BCRi is unknown. Venetoclax is a selective, orally bioavailable BCL-2 inhibitor with activity in patients with CLL, including those who are heavily pretreated or have 17p deletion. This phase 2 study prospectively evaluated venetoclax in patients with R/R CLL after ibrutinib or idelalisib; here we report on patients who received idelalisib as the last BCRi prior to enrollment...
January 5, 2018: Blood
https://www.readbyqxmd.com/read/29304436/specific-effect-of-calcium-ions-on-thermal-gelation-of-aqueous-micellar-casein-suspensions
#16
Gireeshkumar Balakrishnan, Juliana V C Silva, Taco Nicolai, Christophe Chassenieux, Claudine Bovay, Johann Buczkowski, Christophe Schmitt
Aqueous suspensions of micellar casein (MC) gel when heated above a critical temperature that depends on the pH. The effect of adding CaCl2 and EDTA on thermal gelation was studied in order to assess the effect of increasing or decreasing the amount of bound Ca2+ on the process. The effect of adding NaCl was investigated in order to distinguish the effect of Ca2+ binding from the effect of screening of electrostatic interactions. Shear moduli were measured as a function of the temperature during heating ramps up to 90 °C...
December 16, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29302721/impact-of-ritonavir-dose-and-schedule-on-cyp3a-inhibition-and-venetoclax-clinical-pharmacokinetics
#17
Kevin J Freise, Beibei Hu, Ahmed Hamed Salem
PURPOSE: Venetoclax is a selective BCL-2 inhibitor indicated for the treatment of patients with chronic lymphocytic leukemia (CLL). It is predominately metabolized by cytochrome P450 (CYP) 3A. The study objective was to determine the effect of different dosage regimens of ritonavir, a strong CYP3A inhibitor, on the pharmacokinetics of venetoclax in 20 healthy subjects. METHODS: In cohorts 1 and 2, subjects received single 10 mg doses of venetoclax in periods 1 and 2 and a single 50- or 100-mg dose of ritonavir in period 2...
January 4, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29291246/observation-of-the-mott-insulator-to-superfluid-crossover-of-a-driven-dissipative-bose-hubbard-system
#18
Takafumi Tomita, Shuta Nakajima, Ippei Danshita, Yosuke Takasu, Yoshiro Takahashi
Dissipation is ubiquitous in nature and plays a crucial role in quantum systems such as causing decoherence of quantum states. Recently, much attention has been paid to an intriguing possibility of dissipation as an efficient tool for the preparation and manipulation of quantum states. We report the realization of successful demonstration of a novel role of dissipation in a quantum phase transition using cold atoms. We realize an engineered dissipative Bose-Hubbard system by introducing a controllable strength of two-body inelastic collision via photoassociation for ultracold bosons in a three-dimensional optical lattice...
December 2017: Science Advances
https://www.readbyqxmd.com/read/29288607/is-radical-antegrade-modular-pancreatosplenectomy-the-solution-a-systematic-literature-review-and-meta-analysis
#19
Mihnea Dragomir, Mihai Adrian Eftimie
Background: RAMPS is considered, in high volume centers, as the best treatment for adenocarcinoma of the body and tail of the pancreas. Methods: PubMed database was searched. The results of studies that compared RAMPS with SRPS were analyzed by meta-analytical methods. Results: Five studies, published between 2013 and 2016, were suitable for quantitative synthesis. 285 unique patients were included, 135 patients in the RAMPS group and 150 patients in the SRPS group. Regarding retrieved lymph nodes, the mean difference was 6...
November 2017: Chirurgia
https://www.readbyqxmd.com/read/29287160/kinematic-analysis-of-the-thoracic-limb-of-healthy-dogs-during-descending-stair-and-ramp-exercises
#20
Nadia L Kopec, Jane M Williams, Gillian F Tabor
OBJECTIVE To compare the kinematics of the thoracic limb of healthy dogs during descent of stairs and a ramp with those during a trot across a flat surface (control). ANIMALS 8 privately owned dogs. PROCEDURES For each dog, the left thoracic limb was instrumented with 5 anatomic markers to facilitate collection of 2-D kinematic data during each of 3 exercises (descending stairs, descending a ramp, and trotting over a flat surface). The stair exercise consisted of 4 steps with a 35° slope. For the ramp exercise, a solid plank was placed over the steps to create a ramp with a 35° slope...
January 2018: American Journal of Veterinary Research
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