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https://www.readbyqxmd.com/read/28622535/vitamin-d-mediates-the-relationship-between-placental-cathelicidin-and-group-b-streptococcus-colonization-during-pregnancy
#1
Christine C Akoh, Eva K Pressman, Corrie M Whisner, Carrie Thomas, Chang Cao, Tera Kent, Elizabeth Cooper, Kimberly O O'Brien
Vitamin D is thought to modulate innate immune responses, and recent studies have highlighted the autocrine and paracrine functions of vitamin D in the placenta. Our objective was to determine the relationship between maternal vitamin D status and placental antimicrobial peptide (AMP) expression in a group of racially and ethnically diverse pregnant adolescents. In this study, 158 pregnant adolescents were recruited from the Rochester Adolescent Maternity Program (RAMP) in Rochester, NY. Maternal serum concentrations of the vitamin D biomarkers, 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D), were measured at mid-gestation (∼26 weeks) and at delivery...
June 6, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28621882/exercise-capacity-and-functional-performance-in-heart-failure-patients-supported-by-a-left-ventricular-assist-device-at-discharge-from-inpatient-rehabilitation
#2
Thomas Schmidt, Birna Bjarnason-Wehrens, Petra Bartsch, Ezin Deniz, Jan Schmitto, Sebastian Schulte-Eistrup, Detlev Willemsen, Nils Reiss
Adequate physical and functional performance is an important prerequisite for renewed participation and integration in self-determined private and (where appropriate) professional lives following left ventricular assist device (LVAD) implantation. During cardiac rehabilitation (CR), individually adapted exercise programs aim to increase exercise capacity and functional performance. A retrospective analysis of cardiopulmonary exercise capacity and functional performance in LVAD patients at discharge from a cardiac rehabilitation program was conducted...
June 16, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28621496/adrenomedullin-regulates-the-speed-of-oviductal-fluid-flow-in-cattle
#3
Yuka Yoshimoto, Takumi Nishie, Sayaka Ito, Yoshihiko Kobayashi, Yuki Yamamoto, Kiyoshi Okuda, Koji Kimura
Unidirectional flow of oviductal fluid from the ovarian to uterine side of the ampulla plays a significant role in successful pregnancy, and is produced by ciliary beating. Various systems regulate ciliary beating, such as paracrine, autocrine, and endocrine. We hypothesized that Adrenomedullin (ADM) - a peptide hormone that acts via its receptors, which are complexes of Calcitonin receptor-like receptor (CRLR) and Receptor activity-modifying protein (RAMP) 2 or 3-promotes oviductal fluid flow in the ampulla of bovine oviducts...
June 16, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28618852/low-vitamin-d-is-associated-with-infections-and-proinflammatory-cytokines-during-pregnancy
#4
Christine C Akoh, Eva K Pressman, Elizabeth Cooper, Ruth Anne Queenan, Julie Pillittere, Kimberly O O'Brien
Vitamin D is known to regulate innate and adaptive immune processes at the cellular level, but the role of vitamin D status on associated inflammatory processes across pregnancy is unclear. Our primary objective was to evaluate the relationships between serum biomarkers of inflammation (interleukin [IL]-6, IL-10, tumor necrosis factor [TNF]-α), acute-phase proteins (C-reactive protein and hepcidin) and vitamin D status, 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D), measured across pregnancy and in the neonate at birth...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28618548/probability-of-noise-and-rate-induced-tipping
#5
Paul Ritchie, Jan Sieber
We propose an approximation for the probability of tipping when the speed of parameter change and additive white noise interact to cause tipping. Our approximation is valid for small to moderate drift speeds and helps to estimate the probability of false positives and false negatives in early-warning indicators in the case of rate- and noise-induced tipping. We illustrate our approximation on a prototypical model for rate-induced tipping with additive noise using Monte Carlo simulations. The formula can be extended to close encounters of rate-induced tipping and is otherwise applicable to other forms of tipping...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28614667/n-glycosylation-of-asparagine-130-in-the-extracellular-domain-of-the-human-calcitonin-receptor-significantly-increases-peptide-hormone-affinity
#6
Sang-Min Lee, Jason M Booe, Joseph J Gingell, Virginie Sjoelund, Debbie L Hay, Augen A Pioszak
The calcitonin receptor (CTR) is a class B G protein-coupled receptor that is activated by the peptide hormones calcitonin and amylin. Calcitonin regulates bone remodeling through CTR, whereas amylin regulates blood glucose and food intake by activating CTR in complex with receptor activity-modifying proteins (RAMPs). These receptors are targeted clinically for treatment of osteoporosis and diabetes. Here, we define the role of CTR N-glycosylation in hormone binding using purified calcitonin and amylin receptor extracellular domain (ECD) glycoforms and fluorescence polarization/anisotropy and isothermal titration calorimetry peptide-binding assays...
June 14, 2017: Biochemistry
https://www.readbyqxmd.com/read/28604571/hvad-waveform-analysis-as-a-noninvasive-marker-of-pulmonary-capillary-wedge-pressure-a-first-step-toward-the-development-of-a-smart-left-ventricular-assist-device-pump
#7
Jonathan Grinstein, Daniel Rodgers, Sara Kalantari, Gabriel Sayer, Gene H Kim, Nitasha Sarswat, Sirtaz Adatya, Takeyoshi Ota, Valluvan Jeevanandam, Daniel Burkhoff, Nir Uriel
Flow waveforms are an important feature of the HVAD left ventricular assist device (LVAD) that provides information about HVAD function and patient hemodynamics. We assessed the properties of one specific aspect of the waveform, the slope of the ventricular filling phase (VFP), and its correlation with pulmonary capillary wedge pressure (PCWP). A total of 101 screenshots from the HVAD monitor and simultaneous hemodynamic measurements were obtained simultaneously during sequential stages of invasive hemodynamic ramp studies...
June 7, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28603590/antitachycardia-pacing-programming-in-implantable-cardioverter-defibrillator-a-systematic-review
#8
REVIEW
Elia De Maria, Daniele Giacopelli, Ambra Borghi, Letizia Modonesi, Stefano Cappelli
Implantable cardioverter defibrillator (ICD) programming involves several parameters. In recent years antitachycardia pacing (ATP) has gained an increasing importance in the treatment of ventricular arrhythmias, whether slow or fast. It reduces the number of unnecessary and inappropriate shocks and improves both patient's quality of life and device longevity. There is no clear indication regarding the type of ATP to be used, except for the treatment of fast ventricular tachycardias (188 bpm-250 bpm) where it has been shown a greater efficacy and safety of burst compared to ramp; 8 impulses in each sequence of ATP appears to be the best programming option in this setting...
May 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28596737/commentary-validation-of-a-ramp-running-protocol-for-determination-of-the-true-vo2max-in-mice
#9
COMMENT
Koen K Lemaire, Rémi Thomasson, Philippe Noirez, Richard T Jaspers, A J van Soest
No abstract text is available yet for this article.
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28593642/assembly-and-performance-of-a-6-4-t-cryogen-free-dynamic-nuclear-polarization-system
#10
Andhika Kiswandhi, Peter Niedbalski, Christopher Parish, Qing Wang, Lloyd Lumata
We report on the assembly and performance evaluation of a 180 GHz/6.4 T dynamic nuclear polarization (DNP) system based on a cryogen-free superconducting magnet. The DNP system utilizes a variable-field superconducting magnet that can be ramped up to 9 T and equipped with cryocoolers that can cool the sample space with the DNP assembly down to 1.8 K via the Joule-Thomson effect. A homebuilt DNP probe insert with top-tuned NMR coil and microwave port was incorporated into the sample space in which the effective sample temperature is approximately 1...
June 7, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/28591642/effects-of-amplitude-and-predictability-of-perturbations-to-the-arm-on-anticipatory-and-reactionary-muscle-responses-to-maintain-balance
#11
Ali Forghani, Richard Preuss, Theodore Edgar Milner
Disturbances to balance arising from forces applied to the upper limb have received relatively little attention compared to disturbances arising from support surface perturbations. In this study we applied fast ramp perturbations to the hand in anterior, posterior, medial and lateral directions. The effects of perturbation predictability and amplitude on the postural response of upper limb, trunk and lower limb muscles were investigated. Perturbations were applied either in blocks of constant amplitude and direction (predictable) or with direction and amplitude varying randomly (random) from trial to trial...
May 31, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28590007/evidence-for-auditory-motor-impairment-in-individuals-with-hyperfunctional-voice-disorders
#12
Cara E Stepp, Rosemary A Lester-Smith, Defne Abur, Ayoub Daliri, J Pieter Noordzij, Ashling A Lupiani
Purpose: The vocal auditory-motor control of individuals with hyperfunctional voice disorders was examined using a sensorimotor adaptation paradigm. Method: Nine individuals with hyperfunctional voice disorders and 9 individuals with typical voices produced sustained vowels over 160 trials in 2 separate conditions: (a) while experiencing gradual upward perturbations in the fundamental frequency (fo) of their auditory feedback (shift-up) and (b) under no auditory perturbation (control)...
June 7, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28583142/radical-antegrade-modular-pancreatosplenectomy-versus-standard-procedure-in-the-treatment-of-left-sided-pancreatic-cancer-a-systemic-review-and-meta-analysis
#13
Feng Cao, Jia Li, Ang Li, Fei Li
BACKGROUND: Radical antegrade modular pancreatosplenectomy (RAMPS), first reported by Strasberg in 2003, has attracted increasing attention in the treatment of left-sided pancreatic cancer. The limited number of cases eligible for RAMPS makes it difficult to perform any prospective randomized trial of RAMPS versus the standard procedure. Therefore, we performed this systemic review and meta-analysis of the current data to clarify the role of the RAMPS procedure. METHODS: A literature search was performed in electronic databases, including PubMed, Medline, Embase, CNKI and the Cochrane Library...
June 5, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28580177/rapid-multistep-kinetic-model-generation-from-transient-flow-data
#14
Christopher A Hone, Nicholas Holmes, Geoffrey R Akien, Richard A Bourne, Frans L Muller
Today, the generation of kinetic models is still seen as a resource intensive and specialised activity. We report an efficient method of generating reaction profiles from transient flows using a state-of-the-art continuous-flow platform. Experimental data for multistep aromatic nucleophilic substitution reactions are collected from an automated linear gradient flow ramp with online HPLC at the reactor outlet. Using this approach, we generated 16 profiles, at 3 different inlet concentrations and 4 temperatures, in less than 3 hours run time...
April 1, 2017: Reaction Chemistry & Engineering
https://www.readbyqxmd.com/read/28577392/impact-of-in-vehicle-navigation-information-on-lane-change-behavior-in-urban-expressway-diverge-segments
#15
Meiping Yun, Jing Zhao, Jianzhen Zhao, Xuyan Weng, Xiaoguang Yang
Lane-changing behaviors frequently occur at upstream of the urban expressway off-ramp, which possibly cause bottleneck or accident. This paper studies how in-vehicle navigation information impacts lane-changing behavior at this urban expressway diverge segments with comparison to the traditional road signs by conducting a series of driving simulator experiments, in consideration of variation of the first provision time point and traffic flow density. Firstly, the driving simulator is validated by comparing data of lane-changing position and merging gap from both field survey and simulator...
May 31, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28576419/crash-risk-analysis-during-fog-conditions-using-real-time-traffic-data
#16
Yina Wu, Mohamed Abdel-Aty, Jaeyoung Lee
This research investigates the changes of traffic characteristics and crash risks during fog conditions. Using real-time traffic flow and weather data at two regions in Florida, the traffic patterns at the fog duration were compared to the traffic patterns at the clear duration. It was found that the average 5-min speed and the average 5-min volume were prone to decreasing during fog. Based on previous studies, a "Crash Risk Increase Indicator (CRII)" was proposed to explore the differences of crash risk between fog and clear conditions...
May 30, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28574418/clinical-study-on-the-arthroscopic-refreshing-treatment-of-anterior-cruciate-ligament-injury-combined-with-stable-medial-meniscus-ramp-injury
#17
J Yang, K Guan, J Z Wang
This study sought to investigate the clinical efficacy of arthroscopic refreshing treatment of anterior cruciate ligament (ACL) injury combined with stable medial meniscus ramp injury. Sixty-eight patients treated between January 2010 and January 2014 were included, and their clinical data were retrospectively analyzed. All patients, after being treated using ACL reconstruction, were divided into 2 groups according to meniscus injury treatment method. The observation group (31 cases) was treated by arthroscopic refreshing, which removed the tissue on both sides of the tear edge using a cutting knife, while the control group (37 cases) was treated using Fast-fix sutures...
June 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28572336/redox-stratification-of-an-ancient-lake-in-gale-crater-mars
#18
J A Hurowitz, J P Grotzinger, W W Fischer, S M McLennan, R E Milliken, N Stein, A R Vasavada, D F Blake, E Dehouck, J L Eigenbrode, A G Fairén, J Frydenvang, R Gellert, J A Grant, S Gupta, K E Herkenhoff, D W Ming, E B Rampe, M E Schmidt, K L Siebach, K Stack-Morgan, D Y Sumner, R C Wiens
In 2012, NASA's Curiosity rover landed on Mars to assess its potential as a habitat for past life and investigate the paleoclimate record preserved by sedimentary rocks inside the ~150-kilometer-diameter Gale impact crater. Geological reconstructions from Curiosity rover data have revealed an ancient, habitable lake environment fed by rivers draining into the crater. We synthesize geochemical and mineralogical data from lake-bed mudstones collected during the first 1300 martian solar days of rover operations in Gale...
June 2, 2017: Science
https://www.readbyqxmd.com/read/28571830/effect-of-bulk-fill-base-material-on-fracture-strength-of-root-filled-teeth-restored-with-laminate-resin-composite-restorations
#19
N A Taha, G A Maghaireh, A S Ghannam, J E Palamara
OBJECTIVES: To evaluate the effect of using a bulk-fill flowable base material on fracture strength and fracture patterns of root-filled maxillary premolars with MOD preparations restored with laminate restorations. METHODS: Fifty extracted maxillary premolars were selected for the study. Standardized MOD cavities with endodontic treatment were prepared for all teeth, except for intact control. The teeth were divided randomly into five groups (n=10); (Group 1) sound teeth, (Group 2) unrestored teeth; (Group 3) MOD cavities with Vitrebond base and resin-based composite (Ceram...
May 29, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28562380/pharmacokinetics-of-venetoclax-in-patients-with-17p-deletion-chronic-lymphocytic-leukemia
#20
Ahmed Hamed Salem, Martin Dunbar, Suresh K Agarwal
Venetoclax is a first-in-class orally available, B-cell lymphoma (BCL)-2 inhibitor indicated for the treatment of patients with relapsed/refractory chronic lymphocytic leukemia (CLL) harboring the 17p deletion. We used a novel approach for evaluating venetoclax pharmacokinetics using only sparse sampling in 155 patients enrolled in a phase 2, multicenter, open-label study in CLL patients with the 17p deletion. Patients received venetoclax doses within 30 min after the completion of breakfast or the first meal of the day, with no specific recommendations for the fat content in the meal...
May 30, 2017: Anti-cancer Drugs
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