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https://www.readbyqxmd.com/read/29786877/morphomic-malnutrition-score-a-standardized-screening-tool-for-severe-malnutrition-in-adults
#1
Christopher Lee, Erica Raymond, Brian A Derstine, Joshua M Glazer, Rebecca Goulson, Avinash Rajasekaran, Jill Cherry-Bukowiec, Grace L Su, Stewart C Wang
BACKGROUND: Granular diagnostic criteria for adult malnutrition are lacking. OBJECTIVE: This study uses analytic morphomics to define the Morphomic Malnutrition Score (MMS), a robust screening tool for severe malnutrition. METHODS: The study population (n = 643) consisted of 2 cohorts: 1) 124 emergency department patients diagnosed with severe malnutrition by a registered dietitian (RD) and an available computed tomography (CT) scan within 2 days of RD evaluation, and 2) 519 adult kidney donor candidates to represent a healthy cohort...
May 22, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29786612/a-formalism-for-reference-dosimetry-in-photon-beams-in-the-presence-of-a-magnetic-field
#2
Bram van Asselen, Simon J Woodings, Sara L Hackett, Theo L van Soest, Jan G M Kok, Bas W Raaymakers, Jochem W H Wolthaus
A generic formalism is proposed for reference dosimetry in the presence of a magnetic field. Besides the regular correction factors from the conventional reference dosimetry formalisms, two factors are used to take into account magnetic field effects: 1) a dose conversion factor to correct for the change in local dose distribution and 2) a correction of the reading of the dosimeter used for the reference dosimetry measurements. The formalism was applied to the Elekta MRI-Linac, for which the 1.5 T magnetic field is orthogonal to the 7 MV photon beam...
May 22, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29782930/all-atom-four-body-knowledge-based-statistical-potential-to-distinguish-native-tertiary-rna-structures-from-nonnative-folds
#3
Majid Masso
Scientific breakthroughs in recent decades have uncovered the capability of RNA molecules to fulfill a wide array of structural, functional, and regulatory roles in living cells, leading to a concomitantly significant increase in both the number and diversity of experimentally determined RNA three-dimensional (3D) structures. Atomic coordinates from a representative training set of solved RNA structures, displaying low sequence and structure similarity, facilitate derivation of knowledge-based energy functions...
May 18, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29776524/analysis-of-hourly-crash-likelihood-using-unbalanced-panel-data-mixed-logit-model-and-real-time-driving-environmental-big-data
#4
Feng Chen, Suren Chen, Xiaoxiang Ma
INTRODUCTION: Driving environment, including road surface conditions and traffic states, often changes over time and influences crash probability considerably. It becomes stretched for traditional crash frequency models developed in large temporal scales to capture the time-varying characteristics of these factors, which may cause substantial loss of critical driving environmental information on crash prediction. METHOD: Crash prediction models with refined temporal data (hourly records) are developed to characterize the time-varying nature of these contributing factors...
June 2018: Journal of Safety Research
https://www.readbyqxmd.com/read/29773761/surgical-treatment-of-pancreatic-cancer
#5
Wioletta Masiak-Segit, Karol Rawicz-Pruszyński, Magdalena Skórzewska, Wojciech P Polkowski
The only way to cure the patient with adenocarcinoma of the pancreas (RT) is surgical excision of the tumor. The standard surgical treatment of resectable pancreatic carcinoma is considered the classic pancreatoduodenectomy (PD) with the Kausch- Whipple procedure, or the pylorus-preserving PD with the Traverso-Longmire method. The most difficult technically and at the same time the most important PD stage from an oncological point of view is the separation of the head of the pancreas from the superior mesenteric artery...
April 30, 2018: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29772828/wetting-behaviors-of-a-nano-droplet-on-a-rough-solid-substrate-under-perpendicular-electric-field
#6
Fenhong Song, Long Ma, Jing Fan, Qicheng Chen, Lihui Zhang, Ben Q Li
Molecular dynamic simulations were adopted to study the wetting properties of nanoscale droplets on rough silicon solid substrate subject to perpendicular electric fields. The effect of roughness factor and electric field strength on the static and dynamic wetting behaviors of a nano-droplet on a solid surface was investigated at the molecular level. Results show that the static contact angle tends to decrease slightly and show small difference with the increase of roughness factor, while it shows an obvious increase for the ramp-shaped surface because the appearing bottom space reduces the wettability of solid surface...
May 17, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29771628/kif15-functions-as-an-active-mechanical-ratchet
#7
T McHugh, H Drechsler, A D McAinsh, N J Carter, R A Cross
Kif15 is a kinesin-12 that contributes critically to bipolar spindle assembly in humans. Here we use force-ramp experiments in an optical trap to probe the mechanics of single Kif15 molecules under hindering or assisting loads and in a variety of nucleotide states. Whilst unloaded Kif15 is established to be highly processive, we find that under hindering loads, Kif15 takes <∼10 steps. As hindering load is increased, Kif15 forestep:backstep ratio decreases exponentially, with stall occurring at 6 pN. By contrast, under assisting loads, Kif15 detaches readily and rapidly, even from its AMPPNP state...
May 17, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29768106/effect-of-oral-baclofen-on-spasticity-poststroke-responders-versus-non-responders
#8
Shiho Mizuno, Kotaro Takeda, Shinichiro Maeshima, Sonoda Shigeru
Objective To assess quantitatively the efficacy of oral baclofen for spasticity poststroke. Methods The participants were 29 persons poststroke with increased resistance to passive ankle dorsiflexion and ankle clonus on clinical assessment. Baclofen was administered at 20 mg/day for 1 week. The ankle joint was passively dorsiflexed at either 5°/s (slow stretch) or 90°/s (fast stretch) by a custom-built device. The ankle joint angle and resistive torque were measured during the ramp-and-hold stretch, with gastrocnemius electromyogram...
May 16, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29765004/a-comparison-of-the-adjustable-ranges-of-inspiratory-pressurization-during-pressure-controlled-continuous-mandatory-ventilation-of-5-icu-ventilators
#9
Yukiko Koyama, Akinori Uchiyama, Junko Yoshida, Takeshi Yoshida, Tomonori Yamashita, Yuji Fujino
BACKGROUND: Faster inspiratory pressurization can improve patient-ventilator synchrony and reduce the patient's work of breathing during pressure controlled continuous mandatory (PC-CMV) ventilation. The characteristics of the pressurization ramp settings are not standardized across ventilators from different manufacturers. We performed a bench test of 5 models of ICU ventilators to examine the effects of pressurization ramp settings on the actual pressurization. METHODS: A twin-bellows lung model was used, in which one bellow simulates inspiratory muscle activity and the other simulates an adult normal lung model...
May 15, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29763997/technical-note-deep-learning-based-mrac-using-rapid-ultra-short-echo-time-imaging
#10
Hyungseok Jang, Fang Liu, Gengyan Zhao, Tyler Bradshaw, Alan B McMillan
PURPOSE: In this study, we explore the feasibility of a novel framework for MR-based attenuation correction for PET/MR imaging based on deep learning via convolutional neural networks, which enables fully automated and robust estimation of a pseudo CT image based on ultrashort echo time (UTE), fat, and water images obtained by a rapid MR acquisition. METHODS: MR images for MRAC are acquired using dual echo ramped hybrid encoding (dRHE), where both UTE and out-of-phase echo images are obtained within a short single acquisition (35 sec)...
May 15, 2018: Medical Physics
https://www.readbyqxmd.com/read/29761956/-research-on-adaptive-quasi-linear-viscoelastic-model-for-nonlinear-viscoelastic-properties-of-in-vivo-soft-tissues
#11
Heng Wang, Yuanjun Sang
The mechanical behavior modeling of human soft biological tissues is a key issue for a large number of medical applications, such as surgery simulation, surgery planning, diagnosis, etc. To develop a biomechanical model of human soft tissues under large deformation for surgery simulation, the adaptive quasi-linear viscoelastic (AQLV) model was proposed and applied in human forearm soft tissues by indentation tests. An incremental ramp-and-hold test was carried out to calibrate the model parameters. To verify the predictive ability of the AQLV model, the incremental ramp-and-hold test, a single large amplitude ramp-and-hold test and a sinusoidal cyclic test at large strain amplitude were adopted in this study...
October 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29761310/characteristics-of-patients-with-a-relatively-greater-minimum-ve-vco-2-against-peak-vo-2-and-impaired-exercise-tolerance
#12
Taisuke Nakade, Hitoshi Adachi, Makoto Murata, Shigeru Oshima
PURPOSE: Cardiopulmonary exercise testing (CPX) is used to evaluate functional capacity and assess prognosis in cardiac patients. Ventilatory efficiency (VE/VCO2 ) reflects ventilation-perfusion mismatch; the minimum VE/VCO2 value (minVE/VCO2 ) is representative of pulmonary arterial blood flow in individuals without pulmonary disease. Usually, minVE/VCO2 has a strong relationship with the peak oxygen uptake (VO2 ), but dissociation can occur. Therefore, we investigated the relationship between minVE/VCO2 and predicted peak VO2 (peak VO2 %) and evaluated the parameters associated with a discrepancy between these two parameters...
May 14, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29752501/it-is-safe-and-effective-to-use-all-inside-meniscal-repair-devices-for-posteromedial-meniscal-ramp-lesions
#13
Giles Heilpern, Jo Stephen, Simon Ball, Andrew Amis, Andy Williams
PURPOSE: Recently, it has been recognized that meniscocapsular ('ramp') lesions of the posterior one-third of the medial meniscus frequently occur during injuries causing ACL rupture, and that these lesions are easily missed at arthroscopy. Furthermore, it is clear that these lesions are biomechanically significant, adding to the deficits caused by ACL rupture, and that their repair can reverse this. The efficacy of an all inside repair technique has been questioned by some authors and by those who advocate a suture shuttle technique via an accessory posteromedial portal...
May 12, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29745772/specificity-elicits-higher-maximal-and-submaximal-cardiorespiratory-responses-during-a-new-taekwondo-aerobic-test
#14
Matheus Hausen, Pedro Paulo Soares, Marcus Paulo Araujo, Débora Esteves, Hilbert Julio, Roberto Tauil, Marcus Junca, Flávia Porto, Emerson Franchini, Craig Alan Bridge, Jonas Gurgel
PURPOSE: The purpose of the present study was to propose and validate new taekwondo-specific cardiopulmonary exercise tests. METHODS: Twelve male national-level taekwondo athletes (age 20 ± 2 yrs; body mass 67.5 ± 5.7 kg; height 175 ± 8 cm; training experience 7 ± 3 yrs) performed three separate exercise tests in a randomized counterbalanced order: 1) a Treadmill Running Cardiopulmonary Exercise Test (CPET); 2) Continuous and 3) Interval Taekwondo Cardiopulmonary Exercise Tests (cTKDet and iTKDet, respectively)...
May 10, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29745648/stability-enhancement-of-silver-nanowire-networks-with-conformal-zno-coatings-deposited-by-atmospheric-pressure-spatial-atomic-layer-deposition
#15
Afzal Khan, Viet Huong Nguyen, David Muñoz-Rojas, Sara Aghazadehchors, Carmen Jiménez, Ngoc Duy Nguyen, Daniel Bellet
Silver nanowire (AgNW) networks offer excellent electrical and optical properties and have emerged as one of the most attractive alternatives to transparent conductive oxides to be used in flexible optoelectronic applications. However, AgNW networks still suffer from chemical, thermal and electrical instabilities which in some cases can hinder their efficient integration as transparent electrodes in devices such as solar cells, transparent heaters, touch screens or organic light emitting diodes (OLEDs). We have used atmospheric pressure spatial atomic layer deposition (AP-SALD) to fabricate hybrid transparent electrode materials in which the AgNW network is protected by a conformal thin zinc oxide layer...
May 10, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29744360/gear-shifting-of-quadriceps-during-isometric-knee-extension-disclosed-using-ultrasonography
#16
Shu Zhang, Weijian Huang, Yu Zeng, Wenxiu Shi, Xianfen Diao, Xiguang Wei, Shan Ling
Ultrasonography has been widely employed to estimate the morphological changes of muscle during contraction. To further investigate the motion pattern of quadriceps during isometric knee extensions, we studied the relative motion pattern between femur and quadriceps under ultrasonography. An interesting observation is that although the force of isometric knee extension can be controlled to change almost linearly, femur in the simultaneously captured ultrasound video sequences has several different piecewise moving patterns...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29742746/comparison-of-psychological-and-physiological-responses-to-imposed-vs-self-selected-high-intensity-interval-training
#17
Erin Kellogg, Cheyann Cantacessi, Olivia McNamer, Heather Holmes, Robert von Bargen, Richard Ramirez, Daren Gallagher, Stacy Vargas, Ben Santia, Karen Rodriguez, Todd A Astorino
Kellogg, E, Cantacessi, C, McNamer, O, Holmes, H, von Bargen, R, Ramirez, R, Gallagher, D, Vargas, S, Santia, B, Rodriguez, K, and Astorino, TA. Comparison of psychological and physiological responses to imposed vs. self-selected high-intensity interval training. J Strength Cond Res XX(X): 000-000, 2018-High-intensity interval training elicits similar physiological adaptations as moderate intensity continuous training (MICT). Some studies report greater enjoyment to a bout of high-intensity interval exercise (HIIE) vs...
May 8, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29734296/cytokine-resurrection-engineered-il-2-ramps-up-immuno-oncology-responses
#18
Ken Garber
No abstract text is available yet for this article.
May 9, 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29731674/electrophysiological-evidence-for-functional-astrocytic-p2x-3-receptors-in-the-mouse-trigeminal-caudal-nucleus
#19
Jaekwang Lee, Jin Young Bae, C Justin Lee, Yong Chul Bae
Recently, we reported that astrocytes in the trigeminal caudal nucleus (Vc) of the brain stem express a purinergic receptor P2X3 , which is involved in the craniofacial pathologic pain. Although we observed protein expression of P2X3 receptors (P2X3 Rs) in the astrocyte of the Vc, it is still unclear that astrocyte has functional P2X3 Rs in Vc. To address this issue, we recorded asrtocytic P2X3 Rs by using whole cell voltage-clamp recording in the Vc of the GFAP-GFP mice, which was used as a guide to astrocytes with green fluorescence...
April 2018: Experimental Neurobiology
https://www.readbyqxmd.com/read/29729766/editorial-commentary-medial-meniscal-ramp-lesions-lessons-learned-from-the-past-in-the-pursuit-of-evidence
#20
EDITORIAL
Romain Seil
Thirty-five years after their initial description, ramp lesions of the medial meniscus in anterior cruciate ligament (ACL)-deficient knees are slowly being rediscovered. Routinely repaired in open ACL and peripheral reconstructions before the era of arthroscopic ACL reconstruction, ramp lesions have been largely ignored in the last 2 decades. Following the growing number of studies analyzing the causes of residual laxity after ACL reconstructions over the last decade, ramp lesions are increasingly being implicated, and thus investigated, but remain poorly understood...
May 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
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