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https://www.readbyqxmd.com/read/29150760/slow-passage-through-a-hopf-bifurcation-in-excitable-nerve-cables-spatial-delays-and-spatial-memory-effects
#1
L M Bilinsky, S M Baer
It is well established that in problems featuring slow passage through a Hopf bifurcation (dynamic Hopf bifurcation) the transition to large-amplitude oscillations may not occur until the slowly changing parameter considerably exceeds the value predicted from the static Hopf bifurcation analysis (temporal delay effect), with the length of the delay depending upon the initial value of the slowly changing parameter (temporal memory effect). In this paper we introduce new delay and memory effect phenomena using both analytic (WKB method) and numerical methods...
November 17, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/29143840/nonaffine-deformation-and-tunable-yielding-of-colloidal-assemblies-at-the-air-water-interface
#2
Armando Maestro, Alessio Zaccone
Silica nanoparticles trapped at the air-water interface form a 2D solid state with amorphous order. We propose a theoretical model to describe how this solid-like state deforms under a shear strain ramp up to and beyond a yielding point which leads to plastic flow. The model accounts for all the particle-level and many-body physics of the system: nonaffine displacements, local connectivity and its evolution in terms of cage-breaking, and interparticle interactions mediated by the particle chemistry and colloidal forces...
November 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/29141878/lack-of-behavioural-responses-of-humpback-whales-megaptera-novaeangliae-indicate-limited-effectiveness-of-sonar-mitigation
#3
Paul J Wensveen, Petter H Kvadsheim, Frans-Peter A Lam, Alexander M von Benda-Beckmann, Lise D Sivle, Fleur Visser, Charlotte Curé, Peter L Tyack, Patrick J O Miller
Exposure to underwater sound can cause permanent hearing loss and other physiological effects in marine animals. To reduce this risk, naval sonars are sometimes gradually increased in intensity at the start of transmission ('ramp-up'). Here, we conducted experiments in which tagged humpback whales were approached with a ship to test whether a sonar operation preceded by ramp-up reduced three risk indicators - maximum sound pressure level (SPLmax), cumulative sound exposure level (SELcum) and minimum source-whale range (Rmin) - compared with a sonar operation not preceded by ramp-up...
November 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29141215/octopamine-drives-endurance-exercise-adaptations-in-drosophila
#4
Alyson Sujkowski, Divya Ramesh, Axel Brockmann, Robert Wessells
Endurance exercise is an effective therapeutic intervention with substantial pro-healthspan effects. Male Drosophila respond to a ramped daily program of exercise by inducing conserved physiological responses similar to those seen in mice and humans. Female flies respond to an exercise stimulus but do not experience the adaptive training response seen in males. Here, we use female flies as a model to demonstrate that differences in exercise response are mediated by differences in neuronal activity. The activity of octopaminergic neurons is specifically required to induce the conserved cellular and physiological changes seen following endurance training...
November 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/29138274/five-year-effectiveness-of-the-multidisciplinary-risk-assessment-and-management-program-for-primary-care-patients-with-type-2-diabetes-mellitus%C3%A2-ramp-dm-on-dm-related-complications-and-health-service-uses-a-population-based-and-propensity-matched-cohort-study
#5
Eric Yuk Fai Wan, Colman Siu Cheung Fung, Fang Fang Jiao, Esther Yee Tak Yu, Weng Yee Chin, Daniel Yee Tak Fong, Carlos King Ho Wong, Anca Ka Chun Chan, Karina Hiu Yen Chan, Ruby Lai Ping Kwok, Cindy Lo Kuen Lam
OBJECTIVE: To evaluate the 5-year effectiveness of a multidisciplinary Risk Assessment and Management Program for primary care patients with type 2 Diabetes Mellitus (RAMP-DM)‎. RESEARCH DESIGN AND METHODS: A 5-year prospective cohort study was conducted with 121,584 Chinese primary care patients with type 2 DM who were recruited between August 2009 and June 2011. Missing data were dealt with multiple imputations. After excluding patients with prior DM-related complications and one-to-one propensity score matching on all patient characteristics, 26,718 RAMP-DM participants and 26,718 matched usual-care patients were followed up for a median time of 4...
November 14, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29136861/quality-by-design-approach-in-the-development-of-an-ultra-high-performance-liquid-chromatography-method-for-bexsero-meningococcal-group-b-vaccine
#6
Luca Nompari, Serena Orlandini, Benedetta Pasquini, Cristiana Campa, Michele Rovini, Massimo Del Bubba, Sandra Furlanetto
Bexsero is the first approved vaccine for active immunization of individuals from 2 months of age and older to prevent invasive disease caused by Neisseria meningitidis serogroup B. The active components of the vaccine are Neisseria Heparin Binding Antigen, factor H binding protein, Neisseria adhesin A, produced in Escherichia coli cells by recombinant DNA technology, and Outer Membrane Vesicles (expressing Porin A and Porin B), produced by fermentation of Neisseria meningitidis strain NZ98/254. All the Bexsero active components are adsorbed on aluminum hydroxide and the unadsorbed antigens content is a product critical quality attribute...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29131226/a-new-general-approach-to-synthesizing-filled-and-yolk-shell-structured-metal-oxide-microspheres-by-applying-a-carbonaceous-template
#7
Young Jun Hong, Kwang Chul Roh, Jung-Kul Lee, Yun Chan Kang
New mechanisms were found for the formation of metal oxide microspheres with yolk-shell and filled structures by applying carbonaceous template microspheres with high porosity. Repeated impregnation first adopted to achieve a high loading rate of metal precursor in the carbonaceous template provided the breakthrough. The carbonaceous template with an appropriate loading rate of the metal precursor produced metal oxide microspheres with filled and yolk-shell structure depending on the ramping rate and oxygen concentration during the post-treatment process...
November 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/29131193/frequency-and-timing-stability-of-an-airborne-injection-seeded-nd-yag-laser-system-for-direct-detection-wind-lidar
#8
Christian Lemmerz, Oliver Lux, Oliver Reitebuch, Benjamin Witschas, Christian Wührer
We report on the design and performance of the laser deployed in the airborne demonstrator Doppler wind lidar for the Aeolus mission of the European Space Agency (ESA). The all-solid-state, diode-pumped and frequency-tripled Nd:YAG laser is realized as a master oscillator power amplifier (MOPA) system, generating 60 mJ of single-frequency pulses at 355 nm wavelength, 50 Hz repetition rate and 20 ns pulse duration. For the measurement of the Doppler frequency shift over several accumulated laser shots, the frequency stability of the laser is of crucial importance...
November 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29130752/self-reported-difficulty-and-preferences-of-wheeled-mobility-device-users-for-simulated-low-floor-bus-boarding-interior-circulation-and-disembarking
#9
Clive D'Souza, Victor L Paquet, James A Lenker, Edward Steinfeld
BACKGROUND: Low ridership of public transit buses among wheeled mobility device users suggests the need to identify vehicle design conditions that are either particularly accommodating or challenging. The objective of this study was to determine the effects of low-floor bus interior seating configuration and passenger load on wheeled mobility device user-reported difficulty, overall acceptability and design preference. METHODS: Forty-eight wheeled mobility users evaluated three interior design layouts at two levels of passenger load (high vs...
November 13, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29129121/the-validity-and-intra-tester-reliability-of-markerless-motion-capture-to-analyse-kinematics-of-the-bmx-supercross-gate-start
#10
Josephine Grigg, Eric Haakonssen, Evelyne Rathbone, Robin Orr, Justin W L Keogh
The aim of this study was to quantify the validity and intra-tester reliability of a novel method of kinematic measurement. The measurement target was the joint angles of an athlete performing a BMX Supercross (SX) gate start action through the first 1.2 s of movement in situ on a BMX SX ramp using a standard gate start procedure. The method employed GoPro® Hero 4 Silver (GoPro Inc., USA) cameras capturing data at 120 fps 720 p on a 'normal' lens setting. Kinovea 0.8.15 (Kinovea.org, France) was used for analysis...
November 13, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/29121512/composite-pulse-and-partially-dipolar-dephased-multicp-for-improved-quantitative-solid-state-13-c-nmr
#11
Pu Duan, Klaus Schmidt-Rohr
Improved multiple cross polarization (multiCP) pulse sequences for quickly acquiring quantitative (13)C NMR spectra of organic solids are presented. Loss of (13)C magnetization due to imperfect read-out and storage pulses in multiCP has been identified as a significant mechanism limiting polarization enhancement for (13)C sites with weak couplings to (1)H. This problem can be greatly reduced by composite 90° pulses with non-orthogonal phases that flip the magnetization onto the spin-lock field and back to the longitudinal direction for the (1)H repolarization period; the observed loss is <3% for over ±10 kHz resonance offset and up to 20% flip-angle error...
November 6, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29117041/repeated-ramp-tests-on-stable-lvad-patients-reveal-patient-specific-hemodynamic-fingerprint
#12
Teruhiko Imamura, Daniel Burkhoff, Daniel Rodgers, Sirtaz Adatya, Nitasha Sarswat, Gene Kim, Jayant Raikhelkar, Takeyoshi Ota, Tae Song, Colleen Juricek, Valluvan Jeevanandam, Gabriel Sayer, Nir Uriel
Hemodynamic speed ramp tests are used in left ventricular assist device (LVAD) patients to guide speed adjustment and medical therapies. However, the reproducibility of these tests is unknown. In this prospective study, clinically stable LVAD patients underwent echocardiography and right heart catheterization ramp tests followed by a repeat test within 2 years as per institutional protocol. Sixteen patients (61.8 ± 10.5 years old, 50% male, eight with HeartMate II and eight with HVAD) underwent repeated ramp testing...
November 7, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29114511/the-study-of-trunk-and-pelvic-movement-on-mediolateral-ramps-of-various-ramp-angles-during-one-legged-standing
#13
Sang-Yeol Lee, Se-Yeon Park
The purpose of this study was to identify the instability of the trunk and the pelvis of subjects who were standing on differently angled ramps under conditions in which the ramps were crossed. Changes in the trunk and the pelvis while each subject was standing on one leg in the direction of the cross ramps at four angles (0°, 5°, 10°, and 15°) were measured. To identify instability, the trunk inclination, trunk imbalance, pelvic position, pelvic rotation, and pelvic torsion of 20 healthy male subjects were measured...
August 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29111077/international-randomized-controlled-trial-of-transcranial-direct-current-stimulation-in-depression
#14
Colleen K Loo, Mustafa M Husain, William M McDonald, Scott Aaronson, John P O'Reardon, Angelo Alonzo, Cynthia Shannon Weickert, Donel M Martin, Shawn M McClintock, Adith Mohan, Sarah H Lisanby
BACKGROUND: Evidence suggests that transcranial Direct Current Stimulation (tDCS) has antidepressant effects in unipolar depression, but there is limited information for patients with bipolar depression. Additionally, prior research suggests that brain derived neurotrophic factor (BDNF) Val66Met genotype may moderate response to tDCS. OBJECTIVE: To examine tDCS efficacy in unipolar and bipolar depression and assess if BDNF genotype is associated with antidepressant response to tDCS...
October 27, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29101910/spatial-electromyography-distribution-pattern-of-the-vastus-lateralis-muscle-during-ramp-up-contractions-in-parkinson-s-disease-patients
#15
Yuichi Nishikawa, Kohei Watanabe, Tetsuya Takahashi, Naoya Orita, Hiroaki Kimura, Masayasu Matsumoto, Hirofumi Maruyama
Parkinson's disease (PD) related decreases in muscle strength may result from both central and peripheral factors. However, the effect of PD on the neuromuscular system, such as motor unit activation properties, remains unclear. The purpose of the present study was to compare the spatial distribution pattern of electromyographic activity during sustained contractions in healthy subjects and PD patients. Twenty-five female PD patients and 25 healthy age-matched female control subjects performed ramp submaximal contractions during an isometric knee extension from 20% to 80% of the maximal voluntary contraction (MVC)...
October 19, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29099745/a-middleware-solution-for-wireless-iot-applications-in-sparse-smart-cities
#16
Paolo Bellavista, Carlo Giannelli, Stefano Lanzone, Giulio Riberto, Cesare Stefanelli, Mauro Tortonesi
The spread of off-the-shelf mobile devices equipped with multiple wireless interfaces together with sophisticated sensors is paving the way to novel wireless Internet of Things (IoT) environments, characterized by multi-hop infrastructure-less wireless networks where devices carried by users act as sensors/actuators as well as network nodes. In particular, the paper presents Real Ad-hoc Multi-hop Peer-to peer-Wireless IoT Application (RAMP-WIA), a novel solution that facilitates the development, deployment, and management of applications in sparse Smart City environments, characterized by users willing to collaborate by allowing new applications to be deployed on their smartphones to remotely monitor and control fixed/mobile devices...
November 3, 2017: Sensors
https://www.readbyqxmd.com/read/29099695/algorithm-for-treatment-of-patients-with-mesial-occlusion-using-proprietary-orthodontic-device
#17
P Flis, V Filonenko, N Doroshenko
Early elimination of dentoalveolar apparatus orthodontic disorders is the dominant concept in the treatment technique. AIM: to present a sagittal anomalies treatment algorithm, of Class III particularly, in the transitional bite period by the proposed design of individual orthodontic devices with a movable ramp. The treatment algorithm consisted of several blocks: the motivation, the etiological factors establishment, the plan and treatment tactics creation basing on careful diagnosis, the stages of the active period of treatment and the patient management in the retention period...
October 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29098113/hyperbaric-oxygen-therapy-and-oxygen-compatibility-of-skin-and-wound-care-products
#18
Stéphanie F Bernatchez, Joseph Tucker, Gwenael Chiffoleau
Objective: Use test methods to assess the oxygen compatibility of various wound care products. Approach: There are currently no standard test methods specifically for evaluating the oxygen compatibility and safety of materials under hyperbaric oxygen (HBO) conditions. However, tests such as the oxygen index (OI), oxygen exposure (OE), and autogenous ignition temperature (AIT) can provide useful information. Results: The OI test measures the minimum oxygen concentration that will support candle-like burning, and it was used to test 44 materials...
November 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/29093975/case-report-of-multiembolic-cerebrovascular-event-associated-with-ramp-study-echocardiogram
#19
Brian C Butera, Luanda P Grazette, Tracy Lawrence, Michael E Bowdish, Andrew J Yoon
The incidence of ramp test echocardiogram-associated embolic events in the setting of therapeutic anticoagulation is likely rare and has not been reported. We present such a case in a patient with a HeartMate II left ventricular assist device (LVAD) whose serial head computed tomography images, deteriorating clinical course, and the multiembolic nature of the event suggest causality. If the pretest probability of pump thrombosis in an individual LVAD patient is sufficiently high, the potential risks of performing a ramp study echocardiogram may not be warranted, even in the setting of adequate anticoagulation...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/29093684/porcine-stomach-smooth-muscle-force-depends-on-history-effects
#20
André Tomalka, Mischa Borsdorf, Markus Böl, Tobias Siebert
The stomach serves as food reservoir, mixing organ and absorption area for certain substances, while continually varying its position and size. Large dimensional changes during ingestion and gastric emptying of the stomach are associated with large changes in smooth muscle length. These length changes might induce history-effects, namely force depression (FD) following active muscle shortening and force enhancement (FE) following active muscle stretch. Both effects have impact on the force generating capacity of the stomach, and thus functional relevance...
2017: Frontiers in Physiology
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