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https://www.readbyqxmd.com/read/27919929/interleukin-37-and-dendritic-cells-treated-with-interleukin-37-plus-troponin-i-ameliorate-cardiac-remodeling-after-myocardial-infarction
#1
Ruirui Zhu, Haitao Sun, Kunwu Yu, Yucheng Zhong, Huairui Shi, Yuzhen Wei, Xin Su, Wenbin Xu, Quan Luo, Fangyuan Zhang, Zhengfeng Zhu, Kai Meng, Xiaoqi Zhao, Yuzhou Liu, Yi Mao, Peng Cheng, Xiaobo Mao, Qiutang Zeng
BACKGROUND: Excessive immune-mediated inflammatory reactions play a deleterious role in postinfarction ventricular remodeling. Interleukin-37 (IL-37) emerges as an inhibitor of both innate and adaptive immunity. However, the exact role of IL-37 and IL-37 plus troponin I (TnI)-treated dendritic cells (DCs) in ventricular remodeling after myocardial infarction (MI) remains elusive. METHODS AND RESULTS: MI was induced by permanent ligation of the left anterior descending artery...
December 5, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27909224/sarcomeric-protein-modification-during-adrenergic-stress-enhances-cross-bridge-kinetics-and-cardiac-output
#2
Kenneth S Gresham, Ranganath Mamidi, Jiayang Li, Hyerin Kwak, Julian E Stelzer
Molecular adaptations to chronic neurohormonal stress, including sarcomeric protein cleavage and phosphorylation, provide a mechanism to increase ventricular contractility and enhance cardiac output, yet the link between sarcomeric protein modifications and changes in myocardial function remains unclear. To examine the effects of neurohormonal stress on post-translational modifications of sarcomeric proteins, mice were administered combined α- and β-adrenergic receptor agonists (isoproterenol and phenylephrine; IPE) for 14 days using implantable osmotic pumps...
December 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27903616/immediate-rule-out-of-acute-myocardial-infarction-using-electrocardiogram-and-baseline-high-sensitivity-troponin-i
#3
Johannes Tobias Neumann, Nils Arne Sörensen, Francisco Ojeda, Tjark Schwemer, Jonas Lehmacher, Saskia Gönner, Nikolas Jarsetz, Till Keller, Sarina Schaefer, Thomas Renné, Ulf Landmesser, Peter Clemmensen, Nataliya Makarova, Renate B Schnabel, Tanja Zeller, Mahir Karakas, John W Pickering, Martin Than, William Parsonage, Jaimi Greenslade, Louise Cullen, Dirk Westermann, Stefan Blankenberg
AIMS: Serial measurements of high-sensitivity troponin are used to rule out acute myocardial infarction (AMI) with an assay specific cutoff at the 99th percentile. Here, we evaluated the performance of a single admission troponin with a lower cutoff combined with a low risk electrocardiogram (ECG) to rule out AMI. METHODS: Troponin I measured with a high-sensitivity assay (hs-TnI) was determined at admission in 1040 patients presenting with suspected AMI (BACC study)...
November 30, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27895589/amino-acid-changes-at-arginine-204-of-troponin-i-result-in-increased-calcium-sensitivity-of-force-development
#4
Susan Nguyen, Rylie Siu, Shannamar Dewey, Ziyou Cui, Aldrin V Gomes
Mutations in human cardiac troponin I (cTnI) have been associated with restrictive, dilated, and hypertrophic cardiomyopathies. The most commonly occurring residue on cTnI associated with familial hypertrophic cardiomyopathy (FHC) is arginine (R), which is also the most common residue at which multiple mutations occur. Two FHC mutations are known to occur at cTnI arginine 204, R204C and R204H, and both are associated with poor clinical prognosis. The R204H mutation has also been associated with restrictive cardiomyopathy (RCM)...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27875987/biomarkers-of-cardiovascular-injury-and-stress-are-associated-with-increased-frequency-of-ventricular-ectopy-a-population-based-study
#5
Julia Brox Skranes, Gunnar Einvik, Silje Kjeka Namtvedt, Anna Randby, Harald Hrubos-Strøm, Jon Brynildsen, Tor-Arne Hagve, Virend K Somers, Helge Røsjø, Torbjørn Omland
BACKGROUND: Asymptomatic ventricular arrhythmias are common and associated with increased risk of cardiovascular mortality. Cardiac troponins, natriuretic peptides and C-reactive protein (CRP) are also predictive of adverse cardiovascular events in the general population, but limited information is available on the relationship between these biomarkers and ventricular ectopy in a community-based population. The objectives were to evaluate the associations between ventricular ectopic activity and N-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitivity-troponin I (hs-TnI) and hs-CRP in a community-based setting...
November 22, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27853436/the-importance-of-intrinsically-disordered-segments-of-cardiac-troponin-in-modulating-function-by-phosphorylation-and-disease-causing-mutations
#6
REVIEW
Maria Papadaki, Steven B Marston
Troponin plays a central role in regulation of muscle contraction. It is the Ca(2+) switch of striated muscles including the heart and in the cardiac muscle it is physiologically modulated by PKA-dependent phosphorylation at Ser22 and 23. Many cardiomyopathy-related mutations affect Ca(2+) regulation and/or disrupt the relationship between Ca(2+) binding and phosphorylation. Unlike the mechanism of heart activation, the modulation of Ca(2+)-sensitivity by phosphorylation of the cardiac specific N-terminal segment of TnI (1-30) is structurally subtle and has proven hard to investigate...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27815376/impact-of-smoking-on-circulating-cardiac-troponin-i-concentrations-and-cardiovascular-events-in-the-general-population-the-hunt-study
#7
Magnus N Lyngbakken, Julia B Skranes, James A de Lemos, Ståle Nygård, Håvard Dalen, Kristian Hveem, Helge Røsjø, Torbjørn Omland
BACKGROUND: -Both tobacco smoking and circulating cardiac troponin I (cTnI) levels are associated with the risk of acute myocardial infarction (AMI), heart failure (HF) and cardiovascular death. However, whether cardiac troponin I levels differ according to smoking status, or whether smoking modifies the prognostic relationship between cardiac troponin I and outcomes remain unclear. METHODS: -Using data from a large population-based cohort, we assessed the association between smoking and cTnI, and the impact of smoking on the associations between cTnI levels and the incidence of AMI, HF and cardiovascular death...
November 4, 2016: Circulation
https://www.readbyqxmd.com/read/27807948/procedural-resources-utilization-and-clinical-outcomes-with-bioresorbable-everolimus-eluting-scaffolds-and-pt-cr-everolimus-eluting-stent-with-resorbable-abluminal-polymer-in-clinical-practice-a-randomized-trial
#8
Jose M de la Torre Hernandez, Tamara Garcia Camarero, Dae-Hyun Lee, Fermin Sainz Laso, Gabriela Veiga Fernandez, Tania Pino, Silvia Rubio, Pablo Legarra, Jorge R Valdivia, Javier Zueco Gil
OBJECTIVES: We sought to compare the procedural implications of using bioresorbable everolimus-eluting scaffolds (BVS) and Pt-Cr everolimus-eluting stent with abluminal bioabsorbable polymer (Synergy). BACKGROUND: There are important differences in the respective platforms, which could impact on procedural performance, complications and outcomes. METHODS: A prospective, randomized single center study including consecutive patients in stable clinical condition and with lesions amenable to be treated with BVS according to predefined criteria...
November 3, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27801303/levosimendan-use-increases-cardiac-performance-after-coronary-artery-bypass-grafting-in-end-stage-renal-disease-patients
#9
Hakan Atalay, Zeki Temizturk, Hasan Baki Altinsoy, Davut Azboy, Salih Colak, Atakan Atalay, Omer Faruk Dogan
BACKGROUND: The effect of levosimendan on myocardial performance has not been studied in dialysis-dependent end-stage renal disease patients who have undergone coronary artery bypass grafting (CABG) surgery. Our aim was to investigate the effect of levosimendan on postoperative hemodynamic effects in end-stage renal disease patients undergoing CABG operation. METHODS: We performed 58 elective isolated CABG operations in end-stage renal disease patients. The study group received levosimendan at a slow bolus dose of 3 µg/kg, followed by a 24-hour infusion of 0...
October 27, 2016: Heart Surgery Forum
https://www.readbyqxmd.com/read/27775784/serum-troponin-i-concentrations-assessed-18-24-hours-after-coronary-artery-bypass-grafting-are-significant-predictors-of-early-patient-prognosis
#10
Q-L Ma, H-J Wang, M-N Shi, J-H An, J Ma, D Yu, M Tang, F-W Shi
OBJECTIVE: Coronary heart disease (CHD) is a frequent medical condition in developed countries and is one of the most serious diseases threatening patients' lives. Perioperative myocardial infarction is the major cause of perioperative cardiac death and cardiac arrest, but is difficult to be precisely identified by observing clinical symptoms or assessing cardiac enzyme levels or by ECG examination. Therefore, assessment of patient prognosis requires reliable predictors. In this regard, we tested the prognostic value of serum troponin I (TnI) concentrations...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27732551/kinetics-of-troponin-i-in-patients-with-myocardial-injury-after-noncardiac-surgery
#11
Judith A R van Waes, Linda M Peelen, Hans Kemperman, Remco B Grobben, Hendrik M Nathoe, Wilton A van Klei
BACKGROUND: Myocardial injury after noncardiac surgery, as measured by troponin elevation, is strongly associated with mortality. However, it is unknown in which patients prognosis can be improved. The presence of kinetic changes of troponin may be associated with a worse prognosis and warrant more aggressive management. Therefore, we aimed to study the kinetics of troponin in patients with postoperative myocardial injury, and to determine the added predictive value of kinetic changes of troponin on mortality...
October 12, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27707615/prospective-controlled-cohort-study-of-troponin-i-levels-in-patients-undergoing-elective-spine-surgery-for-degenerative-conditions-prone-versus-supine-position
#12
A I Macfarlane, D Rudd, E Knight, L A G Marshman, E P Guazzo, D S Anderson
: Prior studies have suggested that elevated serum Troponin-I (TnI) levels immediately after non-cardiac surgical procedures (8-40%) represent subclinical cardiac stress which independently predicts increased 30-day mortality. Routine post-operative TnI monitoring has therefore been suggested as a standard of care. However, no prior studies have focussed on elective degenerative spine surgery, whilst few have measured pre-op TnI. Further, prolonged prone positioning could represent an additional, independent, cardiac stress...
October 1, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27687223/dorsal-root-ganglionic-field-stimulation-relieves-spontaneous-and-induced-neuropathic-pain-in-rats
#13
Bin Pan, Hongwei Yu, Gregory J Fischer, Jeffery M Kramer, Quinn H Hogan
: Dorsal root ganglion (DRG) electrical stimulation (ganglionic field stimulation [GFS]) is effective in relieving clinical pain, but its mechanism is unknown. We therefore developed a rat model for GFS to test analgesic effects in the context of neuropathic pain. GFS was applied with a bipolar electrode at L4, using parameters replicating clinical use (20 Hz, 150-μs pulse width, current at 80% of motor threshold). Neuropathic pain was generated by tibial nerve injury (TNI). Pain behavior was monitored by determining the threshold for withdrawal from punctate mechanical stimuli, by identifying hyperalgesic responses to noxious mechanical stimuli, and by hypersensitivity to cold...
September 26, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27664622/protein-markers-for-discrimination-of-meat-species-in-raw-beef-pork-and-poultry-and-their-mixtures
#14
Gap-Don Kim, Jin-Kyu Seo, Hyeon-Woong Yum, Jin-Yeon Jeong, Han-Sul Yang
The purpose of this study was to find discrimination markers for four major meat species such as beef, pork, chicken and duck. Myofibrillar and sarcoplasmic proteins isolated from each meat type were analyzed by one-dimensional gel electrophoresis and some proteins were identified through LC-MS/MS analysis. We confirmed that troponin I (TnI), enolase 3, l-lactate dehydrogenase (LDH) and triose-phosphate isomerase (TPI) could be useful markers for discrimination of mammals from poultry due to their different electrophoretic mobility...
February 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27647986/can-we-find-a-good-biochemical-marker-of-early-cardiotoxicity-in-children-treated-with-haematopoietic-stem-cell-transplantation
#15
Agnieszka Zaucha-Prażmo, Elżbieta Sadurska, Katarzyna Drabko, Jerzy R Kowalczyk
Cardiotoxicity is one of the complications following haematopoietic stem cell transplantation (HSCT), but its diagnosis may be hampered due to the presence of different post-transplant comorbidities. The aim of the study was to assess the incidence of cardiac complications and the significance of biochemical markers (NT-proBNP, ANP, ET-1, and TnI) and ECHO systolic and diastolic parameters analysis in children treated with HSCT. Thirty consecutive children (median age 9.6 years) were included in the study. The control group consisted of 14 healthy children (median age of 10...
2016: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/27621853/sufficient-myocardial-protection-of-del-nido-cardioplegia-regardless-of-ventricular-mass-and-myocardial-ischemic-time-in-adult-cardiac-surgical-patients
#16
Ji Seong Kim, Jin Hee Jeong, Sin Ju Moon, Hyuk Ahn, Ho Young Hwang
BACKGROUND: Del Nido (DN) cardioplegic solution (CPS) has been widely used during pediatric cardiac surgery. However, its use in the field of adult cardiac surgery is not popular yet. We evaluated efficacy of DN cardioplegia in adult cardiac surgical patients. METHODS: Fifty-three adult patients (mean age, 54±16 years) who underwent cardiovascular surgery using DN cardioplegia were enrolled. Myocardial troponin I (TnI) level up to three days after surgery and early clinical outcomes were evaluated...
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27611090/evidence-for-acute-myocardial-and-skeletal-muscle-injury-after-serial-transthoracic-shocks-in-healthy-swine
#17
Dominik P Guensch, Janelle Yu, Gobinath Nadeshalingam, Kady Fischer, Jane Shearer, Matthias G Friedrich
BACKGROUND: Previous serological studies have shown controversial results whether defibrillation or cardioversion can cause myocardial injury. Cardiovascular Magnetic Resonance (CMR) can be used to detect myocardial edema, hyperemia and capillary leak as features of acute myocardial injury. The aim of this study was to assess for myocardial and skeletal muscle injury in swine following transthoracic shocks. METHODS: Seventeen anaesthetized swine were examined, with 11 undergoing five synchronized transthoracic shocks (200J)...
2016: PloS One
https://www.readbyqxmd.com/read/27593537/biomarkers-investigation-for-in-hospital-death-in-patients-with-stanford-type-a-acute-aortic-dissection
#18
Ruoxi Zhang, Shuyuan Chen, Hui Zhang, Wei Wang, Jianpang Xing, Yu Wang, Bo Yu, Jingbo Hou
This retrospective study aimed to investigate the predictive value of biomarkers for in-hospital mortality of patients with Stanford type A acute aortic dissection (AAD).AAD is a life-threatening disease with an incidence of about 2.6-3.6 cases per 100,000/year.A total of 67 consecutive Stanford type A AAD patients admitted to hospital were divided into a deceased group and survival group. The baseline information of the patients between two groups was systematically compared, followed by examination of the electrocardiograms (ECG)...
September 28, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27590305/tni-93-a-new-memory-test-for-dementia-detection-in-illiterate-and-low-educated-patients
#19
Didier Maillet, Fanny Matharan, Hervé Le Clésiau, Olivier Bailon, Karine Pérès, Hélène Amieva, Catherine Belin
OBJECTIVE: To validate the TNI-93 test in illiterate and low-educated subjects by setting cutoff scores to discriminate non-demented and demented subjects in a clinical setting (CESILL) and verifying the adequacy of these cutoff scores in a population-based study (AMI cohort). METHOD: We used two study samples. First, a clinical setting (CESILL) comprising normal elderly participants and demented patients, mostly multicultural, low educated, or illiterate, was used to compute the cutoff scores of TNI-93 for the detection of dementia...
September 1, 2016: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/27578801/evaluation-of-host-plant-resistance-of-selected-rice-genotypes-to-the-rice-water-weevil-coleoptera-curculionidae
#20
Suhas S Vyavhare, David R Gealy, Michael O Way, Rodante E Tabien, Rebecca A Pearson
The rice water weevil, Lissorhoptrus oryzophilus Kuschel, is the most important insect pest of rice in the United States. Management of L. oryzophilus mainly depends upon the use of insecticides due to the lack of effective alternative management tactics. A 3-yr field study was conducted to determine if difference exists among rice genotypes and cultivars of inbred tropical japonica subspecies commercially grown in the southern United States [Cocodrie (PI 606331), CL171, and CL151 (PI 654463)] and the germplasm lines of indica subspecies adapted to tropical climates of Asia [WC 4644 (PI 312777), TNI (PI 495830), Rondo (PI 615022), 4612 (PI 615039), TeQing (PI 536047), and 4593 (PI 615031)] for resistance to L...
August 30, 2016: Environmental Entomology
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