Margaux Sivori, Bowen Dempsey, Zoubida Chettouh, Franck Boismoreau, Maïlys Ayerdi, Annaliese Eymael, Sylvain Baulande, Sonia Lameiras, Fanny Coulpier, Olivier Delattre, Hermann Rohrer, Olivier Mirabeau, Jean-François Brunet
The pelvic organs (bladder, rectum, and sex organs) have been represented for a century as receiving autonomic innervation from two pathways - lumbar sympathetic and sacral parasympathetic - by way of a shared relay, the pelvic ganglion, conceived as an assemblage of sympathetic and parasympathetic neurons. Using single-cell RNA sequencing, we find that the mouse pelvic ganglion is made of four classes of neurons, distinct from both sympathetic and parasympathetic ones, albeit with a kinship to the former, but not the latter, through a complex genetic signature...
March 15, 2024: ELife