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https://www.readbyqxmd.com/read/28820897/persistent-infection-due-to-a-small-colony-variant-of-burkholderia-pseudomallei-leads-to-pd-1-upregulation-on-circulating-immune-cells-and-mononuclear-infiltration-in-viscera-of-experimental-balb-c-mice
#1
Jia-Xiang See, Samudi Chandramathi, Mahmood Ameen Abdulla, Jamuna Vadivelu, Esaki M Shankar
BACKGROUND: Melioidosis is a neglected tropical disease endemic across South East Asia and Northern Australia. The etiological agent, Burkholderia pseudomallei (B.pseudomallei), is a Gram-negative, rod-shaped, motile bacterium residing in the soil and muddy water across endemic regions of the tropical world. The bacterium is known to cause persistent infections by remaining latent within host cells for prolonged duration. Reactivation of the recrudescent disease often occurs in elders whose immunity wanes...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28819143/immunomodulatory-and-antioxidant-effects-of-total-flavonoids-of-spatholobus-suberectus-dunn-on-pcv2-infected-mice
#2
Yuan-Fang Fu, Li-He Jiang, Wei-Dan Zhao, Meng Xi-Nan, Shi-Qi Huang, Jian Yang, Ting-Jun Hu, Hai-Lan Chen
Oxidative stress plays an important role in the pathogenesis of virus infection and antioxidants are becoming promising candidates as therapeutic agents. This study is designed to investigate the effect of total flavonoids of Spatholobus suberectus Dunn (TFSD) on oxidative stress in mice induced by porcine circovirus type 2 (PCV2) infection. The PCV2 infection leads to significant decrease in thymus and spleen indices, elevation of xanthine oxidase (XOD) and myeloperoxidase (MPO) activities, reduction in GSH level and GSH to GSSG ratio and decline of superoxide dismutase (SOD) activity, indicating the formation of immunosuppression and oxidative stress...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810995/chondrocyte-viability-after-a-simulated-blast-exposure
#3
K Aaron Shaw, Peter C Johnson, David Williams, Steven D Zumbrun, Richard Topolski, Craig D Cameron
OBJECTIVES: The effects of blast exposure have gained increasing interest in the military medical community with their continued occurrence on the battlefield. The impact of the direct and indirect energy imparted from blasts to hollow viscera, as well as closed head injuries, have been well studied. However, the injury to articular cartilage has not been investigated, despite previous correlations regarding the development of osteoarthritis. The purpose of this study was to assess the degree of injury to articular chondrocytes after exposure to a simulated blast overpressure wave...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28807689/effects-of-polysaccharides-from-abalone-viscera-haliotis-discus-hannai-ino-on-mgc-803cells-proliferation
#4
Rui-Juan Zhang, Yan Shi, Jing Zheng, Xiao-Mei Mao, Zhi-Yu Liu, Qing-Xi Chen, Qin Wang
The polysaccharides (AVP) was obtained from abalone (Haliotis discus hannai Ino) viscera, using the alkaline protease to enzymolysis, sevage method and repeated freezing and thawing method to remove protein and hydrogen peroxide method to depigment. The total sugar content was 46.27±1.5% and uronic acid, sulfate radical, hexosamine and protein contents were 17.44±0.22%, 16.98±0.15%, 0.65±0.02% and 1.64±0.13% in AVP respectively. The main monosaccharide compositions of AVP were D-galactose, D-xylose, D-mannose, D-glucose and D-glucuronic acid...
August 11, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28793400/enhanced-uptake-of-bpa-in-the-presence-of-nanoplastics-can-lead-to-neurotoxic-effects-in-adult-zebrafish
#5
Qiqing Chen, Daqiang Yin, Yunlu Jia, Sabrina Schiwy, Jessica Legradi, Shouye Yang, Henner Hollert
Plastic particles have been proven to be abundant in the aquatic environment, raising concerns about their potential toxic effects. In the present study, we determined the bioaccumulation potential of bisphenol A (BPA) in adult zebrafish (Danio rerio) in the absence and presence of nano-sized plastic particles (nanoplastics, NPPs). Results show that BPA can accumulate in the viscera, gill, head and muscle of zebrafish with 85, 43, 20, and 3μg/g ww after 1d exposure. NPPs were also found to accumulate in different tissues of the fish...
August 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28790552/sister-mary-joseph-nodule-in-an-ovary-adenocarcinoma
#6
Selma Poparic, Asja Prohic, Suada Kuskunovic-Vlahovljak, Emir Guso, Aida Kapetanovic
INTRODUCTION: Sister Mary Joseph Nodule (SMJN) is a metastatic umbilical lesion secondary to a primary malignancy of any viscera, stomach and colon being most common in men, and ovary in women. CASE REPORT: In this article, we present the case of SMJN in a 54-year old female patient. An urgent diagnostic workup was performed with a computerized tomography of abdominal cavity and pelvis showing an expansive tumorous formation covering uterus with a carcinomatosis of peritoneum...
April 2017: Medical Archives
https://www.readbyqxmd.com/read/28781900/blending-of-rodenticide-and-battery-acid-a-rare-and-fatal-suicide-mix
#7
Nisreen Abdul Rahman, Siddhartha Das, Vinod Ashok Chaudhari, Suresh Nandagopal, Bhawana Badhe
BACKGROUND: Self-poisoning usually occurs by the ingestion of a single lethal compound and majority of the poisoning cases in our country are due to the pesticides. Suicide by ingestion of more than one poisonous substance is rare except alcohol and multiple drugs. To the best of our knowledge, suicidal ingestion of a mixture of rodenticide and battery acid has not been reported before in medical literature. CASE PRESENTATION: Here we are discussing a case of simultaneous ingestion of two poisonous substances, i...
2017: Egyptian journal of forensic sciences
https://www.readbyqxmd.com/read/28780444/tissue-specific-distribution-and-maternal-transfer-of-polybrominated-diphenyl-ethers-pbdes-and-their-metabolites-in-adult-common-sole-solea-solea-l-over-an-entire-reproduction-cycle
#8
C Munschy, N Bely, K Héas-Moisan, N Olivier, V Loizeau
Tissue-specific accumulation and distribution of polybrominated diphenyl ethers (PBDEs) and their debrominated metabolites were studied in common sole (Solea solea) over an entire reproduction cycle. The fish were dietary-exposed to selected PBDEs in laboratory-controlled conditions for one year. Fish of both sexes were sampled throughout the reproduction cycle and their muscle, liver, viscera, carcass, skin and gonads (female) were analysed for total lipid content, PBDEs and their debrominated metabolites...
August 3, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28780148/intra-abdominal-hypertension-abdominal-compartment-syndrome-and-the-open-abdomen
#9
REVIEW
William Kirke Rogers, Luis Garcia
Abdominal Compartment Syndrome (ACS) is the endpoint of a process whereby massive interstitial swelling in the abdomen or rapid development of a space-filling lesion within the abdomen (such as ascites or a hematoma) leads to a pathologically increased pressure. This results in so-called Intra-Abdominal Hypertension (IAH), causing decreased perfusion of the kidneys and abdominal viscera and possible difficulties with ventilation and maintenance of cardiac output. These effects contribute to a cascade of ischemia and multiple organ dysfunction with high mortality...
August 2, 2017: Chest
https://www.readbyqxmd.com/read/28767799/retrospective-analysis-of-103-diaphragmatic-injuries-in-patients-operated-in-a-trauma-center
#10
Lucas Figueiredo Cardoso, Marcus Vinícius Capanema Gonçalves, Carla Jorge Machado, Vivian Resende, Michael Pereira Fernandes, Mario Pastore-Neto, Renato Gomes Campanati, Guilherme Victor Oliveira Pimenta Reis
Objective: to analyze the factors associated with death in patients with diaphragmatic injury treated at a trauma reference hospital. Methods: we conducted a retrospective study of patients with diaphragm injury attended at the Risoleta Tolentino Neves Hospital of the Federal University of Minas Gerais, between January 2010 and December 2014. We used The Collector® database of trauma records (MD, USA). We gathered data on demographics, location of the diaphragmatic lesion, site and number of associated lesions, type of therapeutic approach, complications and Injury Severity Score (ISS)...
May 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28765976/safety-and-efficacy-of-transcatheter-embolization-with-glubran-%C3%A2-2-cyanoacrylate-glue-for-acute-arterial-bleeding-a-single-center-experience-with-104-patients
#11
Gilles Abdulmalak, Olivier Chevallier, Nicolas Falvo, Lucy Di Marco, Aurélie Bertaut, Benjamin Moulin, Célina Abi-Khalil, Sophie Gehin, Pierre-Emmanuel Charles, Marianne Latournerie, Marco Midulla, Romaric Loffroy
PURPOSE: To assess the efficacy and the safety of Glubran(®)2 n-butyl cyanoacrylate metacryloxysulfolane (NBCA-MS) transcatheter arterial embolization (TAE) for acute arterial bleeding from varied anatomic sites and to evaluate the predictive factors associated with clinical success and 30-day mortality. METHODS: A retrospective review of consecutive patients who underwent emergent NBCA-MS Glubran(®)2 TAE between July 2014 and August 2016 was conducted. Variables including age, sex, underlying malignancy, cardiovascular comorbidities, coagulation data, systolic blood pressure, and number of red blood cells units (RBC) transfused before TAE were collected...
August 1, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28759251/toxoplasma-gondii-a-foodborne-pathogen-in-the-swine-production-chain-from-a-european-perspective
#12
Alberto De Berardinis, Domenico Paludi, Luca Pennisi, Alberto Vergara
Toxoplasmosis is a foodborne zoonosis transmitted by Toxoplasma gondii, a cosmopolitan protozoan that infects humans through exposure to different parasite stages, in particular by ingestion of tissue cysts or tachyzoites contained in meat, primary offal (viscera), and meat-derived products or ingestion of environmental sporulated oocysts in contaminated food or water. The pig is an important species for infection: raw or undercooked pork consumption not subject to treatment able to inactivate the parasite represents a risk to consumers' health...
July 31, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28748913/d-chiro-inositol-effectively-attenuates-cholestasis-in-bile-duct-ligated-rats-by-improving-bile-acid-secretion-and-attenuating-oxidative-stress
#13
Shuang-Shuang Zhao, Na-Ren Li, Wu-Li Zhao, Hong Liu, Mao-Xu Ge, Yi-Xuan Zhang, Long-Yin Zhao, Xue-Fu You, Hong-Wei He, Rong-Guang Shao
Cholestatic liver diseases are important causes of liver cirrhosis and liver transplantation, but few drugs are available for treatment. D-chiro-inositol (DCI), an isomer of inositol found in many Leguminosae plants and in animal viscera, is used clinically for the treatment of polycystic ovary syndrome (PCOS) and diabetes mellitus. In this study, we investigated whether DCI exerted an anti-cholestatic effect and its underlying mechanisms. A cholestatic rat model was established via bile duct ligation (BDL)...
July 27, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28745814/ocular-localization-of-mycobacterial-lesions-in-tank-reared-juvenile-cobia-rachycentron-canadum
#14
A C N Phillips, R Suepaul, E Soto
Severe clinical mycobacteriosis with consistent ocular lesion localization was diagnosed in a population of 800 juvenile tank-reared Cobia (Rachycentron canadum) which experienced a sudden increase in mortality approximately 5 months after arriving into Trinidad and Tobago from Florida, USA. Moderate daily mortality (15-20 animals per day) persisted for just over 1 month. Moribund fish displayed circling behaviour and had an open-mouth gape upon death. Fish consistently presented with bilateral exophthalmia, corneal cloudiness and hyphema...
July 26, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28744078/partial-anomalous-hepatic-venous-drainage-into-left-sided-atrium-with-right-isomerism-a-case-report-with-review-of-literature
#15
Ishan Kumar, Anmol Bhatia, Kushaljit S Sodhi, Niranjan Khandelwal
Right isomerism, also known as Ivemark syndrome, is an unusual degree of symmetry of some of the abdominothoracic viscera reflecting bilateral right-sidedness. We report an exceedingly rare occurrence of anomalous drainage of the left hepatic vein to the left-sided atrium in a patient of right isomerism. With this case report, we further endorse that the isomerism of atrium might extend beyond the appendages, a view that has been long dismissed by the existing literature.
April 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28739093/individual-surgeon-is-an-independent-risk-factor-for-leak-after-double-stapled-colorectal-anastomosis-an-institutional-analysis-of-800-patients
#16
Eduardo García-Granero, Francisco Navarro, Carlos Cerdán Santacruz, Matteo Frasson, Alvaro García-Granero, Franco Marinello, Blas Flor-Lorente, Alejandro Espí
BACKGROUND: Our aim was to assess whether the individual surgeon is an independent risk factor for anastomotic leak in double-stapled colorectal anastomosis after left colon and rectal cancer resection. METHODS: This retrospective analysis of a prospectively collected database consists of a consecutive series of 800 patients who underwent an elective left colon and rectal resection with a colorectal, double-stapled anastomosis between 1993 and 2009 in a specialized colorectal unit of a tertiary hospital with 7 participating surgeons...
July 21, 2017: Surgery
https://www.readbyqxmd.com/read/28735069/surgical-versus-non-surgical-approach-in-primary-desmoid-type-fibromatosis-patients-a-nationwide-prospective-cohort-from-the-french-sarcoma-group
#17
Nicolas Penel, Axel Le Cesne, Sylvie Bonvalot, Antoine Giraud, Emmanuelle Bompas, Maria Rios, Sébastien Salas, Nicolas Isambert, Pascaline Boudou-Rouquette, Charles Honore, Antoine Italiano, Isabelle Ray-Coquard, Sophie Piperno-Neumann, François Gouin, François Bertucci, Thomas Ryckewaert, Jean-Emmanuel Kurtz, Françoise Ducimetiere, Jean-Michel Coindre, Jean-Yves Blay
PURPOSE: The outcome of desmoid-type fibromatosis (DTF) is unpredictable. Currently, a wait-and-see approach tends to replace large en bloc resection as the first therapeutic approach. Nevertheless, there are no validated factors to guide the treatment choice. METHOD: We conducted a prospective study of 771 confirmed cases of DTF. We analysed event-free survival (EFS) based on the occurrence of relapse after surgery, progressive disease during the wait-and-see approach, or change in therapeutic strategy...
July 20, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28733728/totally-extraperitoneal-approach-for-ventral-hernia
#18
Sante Capitano
BACKGROUND: In open surgery, extraperitoneal sublay mesh implantation is generally preferred to intraperitoneal placement, following the same principles as in "giant prosthetic reinforcement of the visceral sac" described for inguinal hernia repair [1, 2]. Miserez and Penninckx in 2002 described an endoscopic totally preperitoneal ventral hernia repair in a small cohort of 15 cases [3]. Unfortunately, this technique has not spread, probably because of the technical difficulties that require, but not for effectiveness...
July 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28722634/cystic-echinococcosis-in-turkana-kenya-the-role-of-cross-sectional-screening-surveys-in-assessing-the-prevalence-of-human-infection
#19
Nadia Solomon, Eberhard Zeyhle, Jane Carter, John Wachira, Asrat Mengiste, Thomas Romig, Paul J Fields, Calum N L Macpherson
Cystic echinococcosis (CE) is a neglected zoonotic disease caused by Echinococcus granulosus. Infection leads to formation of cysts within the viscera of the human host. In the 1980s, the transhumant population of northwest Turkana, Kenya, was found to have the highest prevalence of CE in the world. In 1983, AMREF Health Africa and the Kenya Medical and Research Institute launched a CE Control Program in northwest Turkana, screening and treating the local people. This epidemiological study of CE in Turkana analyses approximately 30 years of surveillance and surgical data...
May 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28717700/prostate-cancer-burden-at-the-uganda-cancer-institute
#20
Fred Okuku, Jackson Orem, George Holoya, Chris De Boer, Cheryl L Thompson, Matthew M Cooney
PURPOSE: In Uganda, the incidence of prostate cancer is increasing at a rate of 5.2% annually. Data describing presentation and outcomes for patients with prostate cancer are lacking. METHODS: A retrospective review of medical records for men with histologically confirmed prostate cancer at the Uganda Cancer Institute (UCI) from January 1 to December 17, 2012, was performed. RESULTS: Our sample included 182 men whose mean age was 69.5 years (standard deviation, 9...
August 2016: Journal of Global Oncology
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