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https://www.readbyqxmd.com/read/29775632/controlled-delivery-of-a-focal-adhesion-kinase-inhibitor-results-in-accelerated-wound-closure-with-decreased-scar-formation
#1
Kun Ma, Sun Hyung Kwon, Jagannath Padmanabhan, Dominik Duscher, Artem A Trotsyuk, Yixiao Dong, Mohammed Inayathullah, Jayakumar Rajadas, Geoffrey C Gurtner
Formation of scars following wounding or trauma represents a significant healthcare burden costing the economy billions of dollars every year. Activation of focal adhesion kinase (FAK) has been shown to play a pivotal role in transducing mechanical signals to elicit fibrotic responses and scar formation during wound repair. We have previously shown that inhibition of FAK using local injections of a small molecule FAK inhibitor (FAKI) can attenuate scar development in a hypertrophic scar model. Clinical translation of FAKI therapy has been challenging, however, due to the lack of an effective drug delivery system for extensive burn injuries, blast injuries, and large excisional injuries...
May 15, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29771374/our-inner-city-children-inflicted-with-burns-a-retrospective-analysis-of-pediatric-burn-admissions-at-harlem-hospital-ny
#2
Anant Dinesh, Thais Polanco, Khurram Khan, Alexius Ramcharan, Ryan Engdahl
Pediatric burns in the urban environment present special problems. Inner-city communities may be unique with hardships due to various socioeconomic factors. There is lack of literature analyzing pediatric burns in the inner-city, and there has been no report to date reviewing Harlem New York City, one of the most challenged areas in the nation. The aim of this study is to understand the pre-hospital circumstances, socioeconomic factors and management of pediatric burns admitted to our hospital. A retrospective review was performed including all patients aged 0-18 years admitted to the burn care unit from January 2006-May 2017...
May 16, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29771369/building-the-burn-physician-workforce-for-the-21st-century-report-from-february-2014-burns-workforce-conference
#3
Amalia Cochran, David G Greenhalgh
American Burn Association Past President Palmer Q. Bessey, MD, orchestrated a Burn Workforce Conference in Washington, DC in February, 2014, with the goal of evaluating the workforce needs for doctors, nurses and occupational/physical therapists. This report summarizes the issues related to the need for training future surgeons to manage burn patients. General surgery and plastic surgery residents currently have minimal requirements for burn experience during their training. The respective Boards, however, do require knowledge in the management of burn care...
May 16, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29770174/a-simple-technique-to-prolong-molding-time-during-application-of-a-fiberglass-cast-an-in-vitro-study
#4
Mark Ayzenberg, Michael Narvaez, James Raphael
Casting is routinely used for acute and post-operative immobilization and remains a cornerstone in the non-operative management of fractures and deformities. The application of a properly fitted and wellmolded cast, especially for a trainee, can be challenging. We present a simple method of prolonging cure time of fiberglass cast - placing ice in the dip water. Eight-ply, fiveinch fiberglass cast was circumferentially applied to an aluminum-wrapped cardboard cylinder. An electronic, 2-channel temperature sensor (TR-71wf Temp Logger, T&D Corporation, Matsumoto, Japan), accurate to 0...
March 29, 2018: Orthopedic Reviews
https://www.readbyqxmd.com/read/29768662/immersion-in-water-during-labour-and-birth
#5
REVIEW
Elizabeth R Cluett, Ethel Burns, Anna Cuthbert
BACKGROUND: Water immersion during labour and birth is increasingly popular and is becoming widely accepted across many countries, and particularly in midwifery-led care settings. However, there are concerns around neonatal water inhalation, increased requirement for admission to neonatal intensive care unit (NICU), maternal and/or neonatal infection, and obstetric anal sphincter injuries (OASIS). This is an update of a review last published in 2011. OBJECTIVES: To assess the effects of water immersion during labour and/or birth (first, second and third stage of labour) on women and their infants...
May 16, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29768630/what-determines-mortality-in-malignant-pheochromocytoma-report-of-a-case-with-eighteen-year-survival-and-review-of-the-literature
#6
Matheus de Oliveira Andrade, Vinícius Santos da Cunha, Dayana Carla de Oliveira, Olívia Laquis de Moraes, Adriana Lofrano-Porto
Pheochromocytoma (PCC) is a tumor derived from adrenomedullary chromaffin cells. Prognosis of malignant PCC is generally poor due to local recurrence or metastasis. We aim to report a case of malignant PCC with 18-year survival and discuss which factors may be related to mortality and long-term survival in malignant pheochromocytoma. The patient, a 45-year-old man, reported sustained arterial hypertension with paroxysmal episodes of tachycardia, associated with head and neck burning sensation, and hand and foot tremors...
March 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29767579/healthcare-use-costs-and-quality-of-life-in-patients-with-end-stage-kidney-disease-receiving-conservative-management-results-from-a-multi-centre-observational-study-packs
#7
Glenn Phair, Ashley Agus, Charles Normand, Kevin Brazil, Aine Burns, Paul Roderick, Alexander P Maxwell, Colin Thompson, Magdi Yaqoob, Helen Noble
BACKGROUND: Previous research has explored the cost of providing renal replacement therapies in patients with end-stage kidney disease and their quality of life. This is the first study to examine the healthcare costs of patients receiving conservative care without dialysis for end-stage kidney disease. This alternative to dialysis is an option for patients who prefer a supportive and palliative care approach. AIM: Descriptive cost and quality of life analyses alongside a UK-based multi-centre observational study in patients receiving conservative management for end-stage kidney disease...
May 1, 2018: Palliative Medicine
https://www.readbyqxmd.com/read/29765197/impact-of-conjunctival-autograft-on-pterygium-treatment-evaluation-of-related-symptoms-and-patients-satisfaction-after-surgery
#8
Ana Cláudia Viana Wanzeler, Bruna Duarte, Vitor Duarte Moron de Andrade, Monica Alves
Purpose: Pterygium is a fibrovascular condition of the ocular surface that can cause a broad range of irritative and visual symptoms. Controversy exists regarding pterygium mechanisms, management, surgical techniques, adjuvant approaches and impact on patients' quality of life. We performed a retrospective survey focused on the impact of pterygium-related symptoms before surgery and patients' satisfaction after excision surgery followed by conjunctival autograft transplantation with fibrin glue, based on patients' subjective reporting...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29762869/the-organisation-of-critical-care-for-burn-patients-in-the-uk-epidemiology-and-comparison-of-mortality-prediction-models
#9
A P Toft-Petersen, P Ferrando-Vivas, D A Harrison, K Dunn, K M Rowan
In the UK, a network of specialist centres has been set up to provide critical care for burn patients. However, some burn patients are admitted to general intensive care units. Little is known about the casemix of these patients and how it compares with patients in specialist burn centres. It is not known whether burn-specific or generic risk prediction models perform better when applied to patients managed in intensive care units. We examined admissions for burns in the Case Mix Programme Database from April 2010 to March 2016...
May 15, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29762773/animal-and-management-based-welfare-indicators-for-a-conventional-broiler-strain-in-2-barn-types-louisiana-barn-and-closed-barn
#10
Helen Louton, Shana Bergmann, Sven Reese, Michael Erhard, Josef Bachmeier, Beatrice Rösler, Elke Rauch
The aim of this observational study was to describe health- and management-related welfare indicators for a conventional broiler strain housed in 2 barn types (Louisiana barn and closed barn) on the same farm and to assess the impact of age and housing conditions on these indicators. Broilers were examined 4 times in each of 7 fattening periods. Their weight gain, gait score, and further animal-based indicators did not differ between the barn types. On average 46% showed no sign, 51% a minor but visible, and 3% a profound lameness at the end of the fattening period (fattening day 39)...
May 11, 2018: Poultry Science
https://www.readbyqxmd.com/read/29760783/minor-digestive-symptoms-and-their-impact-in-the-general-population-a-cluster-analysis-approach
#11
Diane L'Heureux-Bouron, Sophie Legrain-Raspaud, Helen R Carruthers, P J Whorwell
Background: The classification and treatment of patients who do not meet the criteria for a functional gastrointestinal (GI) disorder has not been well established. This study aimed to record the prevalence of minor digestive symptoms (MDSs) in the general population attempting to divide them into symptom clusters as well as trying to assess their impact and the way sufferers cope with them. Methods: Following face-to-face interviews, a web-based, self-administered questionnaire was designed to capture a range of GI sensations using 34 questions and 12 images depicting abdominal symptoms...
2018: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29758282/stevens-johnson-syndrome-toxic-epidermal-necrolysis-a-multicenter-retrospective-study-of-377-adult-patients-from-the-united-states
#12
Robert G Micheletti, Zelma Chiesa-Fuxench, Megan H Noe, Sasha Stephen, Maria Aleshin, Ashwin Agarwal, Jennifer Boggs, Adela R Cardones, Jennifer K Chen, Jonathan Cotliar, Mark Dp Davis, Arturo Dominguez, Lindy P Fox, Shayna Gordon, Ronald Hamrick, Baran Ho, Lauren C Hughey, Larry M Jones, Benjamin H Kaffenberger, Kimball Kindley, Daniela Kroshinsky, Bernice Y Kwong, Daniel D Miller, Arash Mostaghimi, Amy Musiek, Alex G Ortega-Loayza, Raj Patel, Alba Posligua, Monica Rani, Sandeep Saluja, Victoria R Sharon, Kanade Shinkai, Jessica St John, Nicole Strickland, Erika M Summers, Natalie Sun, Karolyn A Wanat, David A Wetter, Scott Worswick, Caroline Yang, David J Margolis, Joel M Gelfand, Misha Rosenbach
Stevens-Johnson syndrome / toxic epidermal necrolysis (SJS/TEN) is a rare, severe mucocutaneous reaction with few large cohorts reported. This multicenter retrospective study included patients with SJS/TEN seen by inpatient consultative dermatologists at 18 academic medical centers in the United States. 377 adult patients with SJS/TEN between 1/1/2000 and 6/1/2015 were entered, including 69.0% from 2010 onward. The most frequent cause of SJS/TEN was medication reaction (89.7%), most often trimethoprim / sulfamethoxazole (27...
May 11, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29757441/the-safety-and-efficacy-of-propranolol-in-reducing-the-hypermetabolic-response-in-the-pediatric-burn-population
#13
Sylvia Ojeda, Emily Blumenthal, Pamela Stevens, Clark R Andersen, Lucy Robles, David N Herndon, Walter J Meyer
Pediatric burn patients often have hypertension and tachycardia for several years post-injury. Propranolol has shown to be effective in treating the hypermetabolic state secondary to a major burn injury. This study was conducted to document a safe and effective dosing regimen for three different age groups. One hundred four burn-injured children with a 30% to 92% total body surface area burn were treated for 1 to 2 years with propranolol in the outpatient setting. Guardians of the patients were instructed on how to take and monitor the systolic blood pressure and heart rate, and document their vital signs several times a day...
May 11, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29757181/use-of-life-cycle-assessment-to-evaluate-environmental-impacts-associated-with-the-management-of-sludge-and-biogas
#14
Karina Cubas do Amaral, Miguel Mansur Aisse, Gustavo Rafael Collere Possetti, Marcelo Real Prado
Upflow anaerobic sludge blanket (UASB) reactors used in sewage treatment generate two by-products that can be reused: sludge and biogas. At the present time in Brazil, most of this resulting sludge is disposed of in sanitary landfills, while biogas is commonly burned off in low-efficiency flares. The aim of the present study was to use life cycle assessment to evaluate the environmental impacts from four different treatment and final destination scenarios for the main by-products of wastewater treatment plants...
May 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29754894/lethal-area-50-percent-la50-or-standardized-mortality-ratio-smr-which-one-is-more-conclusive
#15
Ali Ahmadabadi, Majid Khadem-Rezaiyan, Alireza Sedaghat, Seyed Hasan Tavousi, Nastaran Khorrampazhouh, Atiyeh Mohsenpour, Zeinab Goudarzi, Masoumeh Hassanpour
BACKGROUND: Burn injuries impose a considerable burden on healthcare systems. It is among the top ten causes of mortality and a major cause of disability. This study aimed to calculate and compare the lethal area fifty percent (LA50) and standardized mortality ratio (SMR) in patients with burns. METHODS: This is a five-year cross-sectional study. The study population consisted of 3284 patients with acute burns who were admitted to the Burn Department of Imam Reza Hospital in Mashhad, Iran, from 2010 to 2015...
May 10, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29753519/state-of-the-national-emergency-department-workforce-who-provides-care-where
#16
M Kennedy Hall, Kevin Burns, Michael Carius, Mitchel Erickson, Jane Hall, Arjun Venkatesh
STUDY OBJECTIVE: We describe the current US emergency medicine workforce in terms of clinician type and examine rural and urban emergency medicine workforce differences. METHODS: Using the 2014 Medicare Public Use Files, we performed a cross-sectional study of all clinicians receiving reimbursement for evaluation and management (E/M) services (levels 1 to 5) to Medicare fee-for-service Part B beneficiaries in the emergency department. Providers were defined as emergency physicians, nonemergency physicians, or advanced practice providers, corresponding with the Medicare Public Use Files data set...
May 9, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29753454/response-of-a-local-hospital-to-a-burn-disaster-contributory-factors-leading-to-zero-mortality-outcomes
#17
Eng-Kean Yeong, Ciaran P O'Boyle, Hui-Fu Huang, Hao-Chih Tai, Yen-Chun Hsu, Shu-Yang Chuang, Yu-Feng Wu, Che-Wei Chang, Tom J Liu, Hong-Shiee Lai
OBJECTIVE: To investigate the outcomes of a local healthcare system in managing a burn mass casualty incident (BMCI). METHODS: Thirty-three victims admitted to the National Taiwan University Hospital within 96h of the explosion were included in the study. Data were recorded on: patient demographics, Baux score, laboratory data, management response, treatment strategies, and outcomes. Case notes from June 27, 2015 to November 2015 were reviewed with a focus on fluid resuscitation, ventilation support, nutrition, infection control, sepsis treatment, and wound closure plan...
May 9, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29752682/new-perspectives-in-fire-management-in-south-american-savannas-the-importance-of-intercultural-governance
#18
Jayalaxshmi Mistry, Isabel Belloni Schmidt, Ludivine Eloy, Bibiana Bilbao
Wildfires continue to cause damage to property, livelihoods and environments around the world. Acknowledging that dealing with wildfires has to go beyond fire-fighting, governments in countries with fire-prone ecosystems have begun to recognize the multiple perspectives of landscape burning and the need to engage with local communities and their practices. In this perspective, we outline the experiences of Brazil and Venezuela, two countries where fire management has been highly contested, but where there have been recent advances in fire management approaches...
May 11, 2018: Ambio
https://www.readbyqxmd.com/read/29752642/can-short-term-pasture-management-increase-c-balance-in-the-atlantic-rainforest
#19
Paulo Roberto da Rocha Junior, Felipe Vaz Andrade, Lucas Santos Satiro, Guilherme Kangussú Donagemma, Eduardo de Sá Mendonça
Few studies have shown the importance of different pasture management practices on C storage and the reduction of CO2 -C emissions in tropical conditions. The objective of the present study was to determine short-term changes in C pools and C balance from different pasture management practices established in the Atlantic Rainforest. A field study was carried out in Alegre, ES, Brazil from September 2013 to August 2014 to investigate the first-year effect of pasture management practices on a Udult clayey soil...
May 11, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29752268/preferred-hexoses-influence-long-term-memory-and-induction-of-lactose-catabolism-by-streptococcus-mutans
#20
Lin Zeng, Lulu Chen, Robert A Burne
Bacteria prioritize sugar metabolism via carbohydrate catabolite repression, which regulates global gene expression to optimize the catabolism of preferred substrates. Here, we report an unusual long-term memory effect in certain Streptococcus mutans strains that alters adaptation to growth on lactose after prior exposure to glucose or fructose. In strain GS-5, cells that were first cultured on fructose then transferred to lactose displayed an exceptionally long lag (>11 h) and slower growth, compared to cells first cultured on glucose or cellobiose, which displayed a reduction in lag phase by as much as 10 h...
May 11, 2018: Applied and Environmental Microbiology
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