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https://www.readbyqxmd.com/read/27922955/review-of-engines-of-discovery-and-innovation-by-economou-js-in-ann-surg-264-405-412-2016
#1
Tara L Braun, Larry H Hollier
No abstract text is available yet for this article.
December 5, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27922848/lung-regeneration-steps-toward-clinical-implementation-and-use
#2
Elizabeth A Calle, Katherine L Leiby, MichaSam B Raredon, Laura E Niklason
PURPOSE OF REVIEW: Whole lung tissue engineering is a relatively new area of investigation. In a short time, however, the field has advanced quickly beyond proof of concept studies in rodents and now stands on the cusp of wide-spread scale up to large animal studies. Therefore, this technology is ever closer to being directly clinically relevant. RECENT FINDINGS: The main themes in the literature include refinement of the fundamental components of whole lung engineering and increasing effort to direct induced pluripotent stem cells and lung progenitor cells toward use in lung regeneration...
December 5, 2016: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/27922518/hepatitis-c-point-of-care-testing-in-vulnerable-populations-a-human-factors-study
#3
Donna M Zucker, Akshaya Shanmugam
One third of all hepatitis C virus (HCV) cases in the United States are incarcerated in jails and prisons. Hepatitis C virus testing is primarily accomplished through a clinical laboratory, yet point-of-care (POC) testing is less invasive and results are available in 20 minutes compared with up to 3 weeks. The purpose of this article was to describe the findings of a collaborative project between the Colleges of Engineering and Nursing at the University of Massachusetts Amherst in executing a human factors study for HCV antibody testing and screening...
November 2016: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
https://www.readbyqxmd.com/read/27922201/high-performance-air-stable-field-effect-transistors-based-on-heteroatom-substituted-naphthalenediimide-benzothiadiazole-copolymers-exhibiting-ultrahigh-electron-mobility-up-to-8-5-cm-v-1-s-1
#4
Zhiyuan Zhao, Zhihong Yin, Huajie Chen, Liping Zheng, Chunguang Zhu, Long Zhang, Songting Tan, Hanlin Wang, Yunlong Guo, Qingxin Tang, Yunqi Liu
Rational heteroatom engineering is applied to develop high-performance electron-transporting naphthalenediimide copolymers. Top-gate field-effect transistors fabricated from selenophene-containing polymers achieve an ultrahigh electron mobility of 8.5 cm(2) V(-1) s(-1) and excellent air-stability. The results demonstrate that the incorporation of selenophene heterocycles into the polymers can improve film-forming ability, intermoleclar interaction, and carrier transport significantly.
December 6, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27922128/space-geodetic-monitoring-of-engineered-structures-the-ongoing-destabilization-of-the-mosul-dam-iraq
#5
Pietro Milillo, Roland Bürgmann, Paul Lundgren, Jacqueline Salzer, Daniele Perissin, Eric Fielding, Filippo Biondi, Giovanni Milillo
We present a detailed survey of the ongoing destabilization process of the Mosul dam. The dam is located on the Tigris river and is the biggest hydraulic structure in Iraq. From a geological point of view the dam foundation is poor due to a site geology formed by alternating strata of highly soluble materials including gypsum, anhydrite, marl and limestone. Here we present the first multi-sensor cumulative deformation map for the dam generated from space-based interferometric synthetic aperture radar measurements from the Italian constellation COSMO-SkyMed and the European sensor Sentinel-1a over the period 2014-2016 that we compare to an older dataset spanning 2004-2010 acquired with the European Envisat satellite...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27922071/a-carotenogenic-mini-pathway-introduced-into-white-corn-does-not-affect-development-or-agronomic-performance
#6
Daniela Zanga, Teresa Capell, Gustavo A Slafer, Paul Christou, Roxana Savin
High-carotenoid corn (Carolight®) has been developed as a vehicle to deliver pro-vitamin A in the diet and thus address vitamin A deficiency in at-risk populations in developing countries. Like any other novel crop, the performance of Carolight® must be tested in different environments to ensure that optimal yields and productivity are maintained, particularly in this case to ensure that the engineered metabolic pathway does not attract a yield penalty. Here we compared the performance of Carolight® with its near isogenic white corn inbred parental line under greenhouse and field conditions, and monitored the stability of the introduced trait...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27922049/identification-of-kiaa1199-as-a-biomarker-for-pancreatic-intraepithelial-neoplasia
#7
Han Na Suh, Sohee Jun, Ah-Young Oh, Mrinal Srivastava, Sunhye Lee, Cullen M Taniguchi, Songlin Zhang, Won Sup Lee, Junjie Chen, Bum-Joon Park, Jae-Il Park
Pancreatic cancer is one of the most aggressive cancers and has an extremely poor prognosis. Despite recent progress in both basic and clinical research, most pancreatic cancers are detected at an incurable stage owing to the absence of disease-specific symptoms. Thus, developing novel approaches for detecting pancreatic cancer at an early stage is imperative. Our in silico and immunohistochemical analyses showed that KIAA1199 is specifically expressed in human pancreatic cancer cells and pancreatic intraepithelial neoplasia, the early lesion of pancreatic cancer, in a genetically engineered mouse model and in human patient samples...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27921382/core-shell-silk-hydrogels-with-spatially-tuned-conformations-as-drug-delivery-system
#8
Le-Ping Yan, Joaquim M Oliveira, Ana L Oliveira, Rui L Reis
Hydrogels of spatially controlled physicochemical properties are appealing platforms for tissue engineering and drug delivery. In this study, core-shell silk fibroin (SF) hydrogels of spatially controlled conformation were developed. The core-shell structure in the hydrogels was formed by means of soaking the preformed (enzymatically crosslinked) random coil SF hydrogels in methanol. When increasing the methanol treatment time from 1 to 10 min, the thickness of the shell layer can be tuned from about 200 to about 850 μm as measured in wet status...
December 5, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27921218/from-problem-solving-to-problem-definition-scrutinizing-the-complex-nature-of-clinical-practice
#9
Sayra Cristancho, Lorelei Lingard, Glenn Regehr
In medical education, we have tended to present problems as being singular, stable, and solvable. Problem solving has, therefore, drawn much of medical education researchers' attention. This focus has been important but it is limited in terms of preparing clinicians to deal with the complexity of the 21st century healthcare system in which they will provide team-based care for patients with complex medical illness. In this paper, we use the Soft Systems Engineering principles to introduce the idea that in complex, team-based situations, problems usually involve divergent views and evolve with multiple solution iterations...
December 5, 2016: Perspectives on Medical Education
https://www.readbyqxmd.com/read/27920940/3d-printing-in-neurosurgery-a-systematic-review
#10
REVIEW
Michael Randazzo, Jared M Pisapia, Nickpreet Singh, Jayesh P Thawani
BACKGROUND: The recent expansion of three-dimensional (3D) printing technology into the field of neurosurgery has prompted a widespread investigation of its utility. In this article, we review the current body of literature describing rapid prototyping techniques with applications to the practice of neurosurgery. METHODS: An extensive and systematic search of the Compendex, Scopus, and PubMed medical databases was conducted using keywords relating to 3D printing and neurosurgery...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27920668/getting-mirna-therapeutics-into-the-target-cells-for-neurodegenerative-diseases-a-mini-review
#11
REVIEW
Ming Ming Wen
miRNAs play important roles in modulating gene expression in varying cellular processes and disease pathogenesis, including neurodegenerative diseases. Several miRNAs are expressed in the brain, control brain development and are identified as important biomarkers in the pathogenesis of motor-and neuro-cognitive diseases such as Alzheimer's (AD), Huntington's and Parkinson's diseases (PD) and amyotrophic lateral sclerosis. These remarkable miRNAs could be used as diagnostic markers and therapeutic targeting potential for many stressful and untreatable progressive neurodegenerative diseases...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27920525/fabrication-and-characterization-of-drug-loaded-nano-hydroxyapatite-polyamide-66-scaffolds-modified-with-carbon-nanotubes-and-silk-fibroin
#12
Meng-Zhu Yao, Ming-Yi Huang-Fu, Hui-Na Liu, Xia-Rong Wang, Xiaoxia Sheng, Jian-Qing Gao
Nano-hydroxyapatite/polyamide 66 (nHA/PA66) porous scaffolds were fabricated by a phase inversion method. Carbon nanotubes (CNTs) and silk fibroin (SF) were used to modify the surface of the nHA/PA66 scaffolds by freeze-drying and cross-linking. Dexamethasone was absorbed to the CNTs to promote the osteogenic differentiation of bone mesenchymal stem cells (BMSCs). The cell viability of BMSCs was investigated by changing the concentration of the CNT dispersion, and the most biocompatible scaffold was selected...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27920446/life-as-a-fuel-cell-engineer
#13
Sjoerd van Empelen
No abstract text is available yet for this article.
December 6, 2016: Nature Nanotechnology
https://www.readbyqxmd.com/read/27920439/activity-targets-for-nanostructured-platinum-group-metal-free-catalysts-in-hydroxide-exchange-membrane-fuel-cells
#14
Brian P Setzler, Zhongbin Zhuang, Jarrid A Wittkopf, Yushan Yan
Fuel cells are the zero-emission automotive power source that best preserves the advantages of gasoline automobiles: low upfront cost, long driving range and fast refuelling. To make fuel-cell cars a reality, the US Department of Energy has set a fuel cell system cost target of US$30 kW(-1) in the long-term, which equates to US$2,400 per vehicle, excluding several major powertrain components (in comparison, a basic, but complete, internal combustion engine system costs approximately US$3,000). To date, most research for automotive applications has focused on proton exchange membrane fuel cells (PEMFCs), because these systems have demonstrated the highest power density...
December 6, 2016: Nature Nanotechnology
https://www.readbyqxmd.com/read/27920437/developing-a-scalable-artificial-photosynthesis-technology-through-nanomaterials-by-design
#15
Nathan S Lewis
An artificial photosynthetic system that directly produces fuels from sunlight could provide an approach to scalable energy storage and a technology for the carbon-neutral production of high-energy-density transportation fuels. A variety of designs are currently being explored to create a viable artificial photosynthetic system, and the most technologically advanced systems are based on semiconducting photoelectrodes. Here, I discuss the development of an approach that is based on an architecture, first conceived around a decade ago, that combines arrays of semiconducting microwires with flexible polymeric membranes...
December 6, 2016: Nature Nanotechnology
https://www.readbyqxmd.com/read/27920297/role-of-ribonucleotide-reductase-on-bacillus-subtilis-stress-associated-mutagenesis
#16
Karla Viridiana Castro-Cerritos, Ronald E Yasbin, Eduardo A Robleto, Mario Pedraza-Reyes
: The Gram-positive microorganism Bacillus subtilis relies on a single class Ib ribonucleotide reductase (RNR) to generate 2' -deoxyribonucleotides (dNDPs) for DNA replication and repair. In this work, we investigated the influence of RNR levels on B. subtilis stationary-phase-associated mutagenesis (SPM). Since RNR is essential in this bacterium, we engineered a conditional mutant in the strain B. subtilis YB955 (hisC952, metB5, leu427) in which expression of the nrdEF operon was modulated by isopropyl-β-D-thiogalactopyranoside (IPTG)...
December 5, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27920024/biology-and-pathobiology-of-tdp-43-and-emergent-therapeutic-strategies
#17
Lin Guo, James Shorter
Cytoplasmic TDP-43 mislocalization and aggregation is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 is an RNA-binding protein (RBP) with a prion-like domain (PrLD) that promotes TDP-43 misfolding. PrLDs possess compositional similarity to canonical prion domains of various yeast proteins, including Sup35. Strikingly, disease-causing TDP-43 mutations reside almost exclusively in the PrLD and can enhance TDP-43 misfolding and toxicity. Another ∼70 human RBPs harbor PrLDs, including FUS, TAF15, EWSR1, hnRNPA1, and hnRNPA2, which have surfaced in the etiology of neurodegenerative diseases...
December 5, 2016: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/27919888/identification-of-a-novel-lincomycin-resistance-mutation-associated-with-activation-of-antibiotic-production-in-streptomyces-coelicolor-a3-2
#18
Guojun Wang, Masumi Izawa, Xiaoge Yang, Dongbo Xu, Yukinori Tanaka, Kozo Ochi
Comparative genome sequencing analysis of a lincomycin-resistant strain of Streptomyces coelicolor A3 (2) and the wild type strain identified a novel mutation conferring a high level of lincomycin resistance. Surprisingly, the new mutation was an in-frame DNA deletion in the genes SCO4597-SCO4598, resulting in formation of the hybrid gene linR SCO4597 and SCO4598 encode two histidine kinases, which, together with SCO4596, encoding a response regulator, constitute a unique two-component system. Sequence analysis indicated that these three genes and their arrangement patterns are ubiquitous among all Streptomyces genomes sequenced to date, suggesting these genes play important regulatory roles...
December 5, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27919839/heparin-hyaluronic-acid-hydrogel-for-efficient-cellular-activities-of-3d-encapsulated-adipose-derived-stem-cells
#19
Kihak Gwon, Eunsol Kim, Giyoong Tae
We have developed stem cell-responsive, heparin-hyaluronic acid (Hep-HA) hydrogel, crosslinked by thiolated heparin (Hep-SH) and methacrylated hyaluronic acid (HA-MA) via visible light mediated, thiol-ene reaction. Physical properties of the hydrogel (gelation time, storage modulus, and swelling ratio) were tunable by adjusting light intensity, initiator/polymer concentration, and precursor pH. Culture of human adipose derived mesenchymal stem cells (ADSCs) using this hydrogel was characterized and compared with the control hydrogels including Hep-PEG hydrogel, PEG-HA hydrogel...
December 2, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27919791/biosensor-assisted-transcriptional-regulator-engineering-for-methylobacterium-extorquens-am1-to-improve-mevalonate-synthesis-by-increasing-the-acetyl-coa-supply
#20
Wei-Fan Liang, Lan-Yu Cui, Jin-Yu Cui, Kai-Wen Yu, Song Yang, Chong Zhang, Xin-Hui Xing
Acetyl-CoA is not only an important intermediate metabolite for cells but also a significant precursor for production of industrially interesting metabolites. Methylobacterium extorquens AM1, a model strain of methylotrophic cell factories using methanol as carbon source, is of interest because it produces abundant coenzyme A compounds capable of directing to synthesis of different useful compounds from methanol. However, acetyl-CoA always does not efficiently accumulate in M. extorquens AM1, as it is located in the center of three cyclic central metabolic pathways...
December 3, 2016: Metabolic Engineering
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