keyword
MENU ▼
Read by QxMD icon Read
search

Contract relax

keyword
https://www.readbyqxmd.com/read/28337515/assessment-of-cardiac-function-in-fetuses-of-gestational-diabetic-mothers-during-the-second-trimester
#1
Mehnaz Atiq, Anum Ikram, Batool M Hussain, Bakhtawar Saleem
Fetuses of diabetic mothers may have structural or functional cardiac abnormalities which increase morbidity and mortality. Isolated functional abnormalities have been identified in the third trimester. The aim of the present study was to assess fetal cardiac function (systolic, diastolic, and global myocardial performance) in the second trimester in mothers with gestational diabetes, and also to relate cardiac function with glycemic control. Mothers with gestational diabetes mellitus referred for fetal cardiac evaluation in the second trimester (between 19 and 24 weeks) from March 2015 to February 2016 were enrolled as case subjects in this study...
March 24, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28335103/correlation-between-gastric-emptying-and-gastric-adaptive-relaxation-influenced-by-amino-acids
#2
Masayuki Uchida, Orie Kobayashi, Chizuru Saito
Background/Aims: Amino acids have many physiological activities. We report the correlation between gastric emptying and gastric adaptive relaxation using tryptophan and amino acids with a straight alkyl chain, hydroxylated chain, and branched chain. Here we sought to further clarify the correlation between gastric emptying and gastric adaptive relaxation by using other amino acids. Methods: In Sprague-Dawley rats, gastric emptying was evaluated by a breath test using [1-¹³C] acetic acid...
March 23, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28334715/potassium-channel-independent-relaxing-influence-of-adipose-tissue-on-mouse-carotid-artery
#3
Marta Laskowski, Cathrin Andersson, Emilie Eliasson, Veronika Golubinskaya, Holger Nilsson
Since the cardiovascular consequences of obesity reportedly vary in different types of obesity, we investigated the influence of adipose tissue from different locales on the phenylephrine-induced tone of the mouse carotid artery. Vessels were mounted in a Mulvany-Halpern-type wire myograph, and adipose tissue, from the back (brown) or mesenteric or inguinal subcutaneous (white), was placed around the artery. Contractile responses to phenylephrine were not affected by brown adipose tissue but were reduced (p < 0...
March 24, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28328397/age-dependent-diastolic-heart-failure-in-an-in-vivo-drosophila-model
#4
Matthew P Klassen, Christian J Peters, Shiwei Zhou, Hannah H Williams, Lily Yeh Jan, Yuh Nung Jan
While the signals and complexes that coordinate the heartbeat are well established, how the heart maintains its electromechanical rhythm over a lifetime remains an open question with significant implications to human health. Reasoning that this homeostatic challenge confronts all pulsatile organs, we developed a high resolution imaging and analysis toolset for measuring cardiac function in intact, unanesthetized Drosophila melanogaster. We demonstrate that, as in humans, normal aging primarily manifests as defects in relaxation (diastole) while preserving contractile performance...
March 22, 2017: ELife
https://www.readbyqxmd.com/read/28326563/early-structural-and-functional-signature-of-3-day-human-skeletal-muscle-disuse-using-the-dry-immersion-model
#5
Rémi Demangel, Loïc Treffel, Guillaume Py, Thomas Brioche, Allan F Pagano, Marie-Pierre Bareille, Arnaud Beck, Laurence Pessemesse, Robin Candau, Claude Gharib, Angèle Chopard, Catherine Millet
Microgravity and hypoactivity are associated with skeletal muscle deconditioning. The decrease of muscle mass is an exponential decay with major changes in the first days. The purpose of the study was to dissect out the effects of a short-term 3-day dry immersion (DI) on human quadriceps muscle function and structure. The DI model, by suppressing all support zones, accurately reproduces the effects of microgravity. Twelve healthy volunteers (32 ± 5 yrs) completed 3 days of DI. Muscle function was investigated through maximal voluntary contraction (MVC) tests and muscle viscoelasticity...
March 22, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28325672/new-parameter-derived-from-three-dimensional-speckle-tracking-echocardiography-for-the-estimation-of-left-ventricular-filling-pressure-in-nondilated-hearts
#6
Daisuke Sakurai, Toshihiko Asanuma, Kasumi Masuda, Hikaru Koriyama, Satoshi Nakatani
BACKGROUND: E/e' is clinically useful for the noninvasive assessment of left ventricular (LV) filling pressure. However, its use in some conditions is controversial, and angle dependence of the Doppler measurement and preload dependence of mitral e' in nondilated hearts represent major problems. The ratio of early filling rate derived from the time derivative of LV volume to early diastolic strain rate (FRe/SRe), similar to E/e', by three-dimensional (3D) speckle-tracking echocardiography has the potential to address such limitations...
March 18, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28324997/assessing-the-development-of-fetal-myocardial-function-by-a-novel-doppler-myocardial-performance-index
#7
Ahsan H Khandoker, F Marzbanrad, Y Kimura, Saeed Al Nuaimi, M Palaniswami
Doppler-derived myocardial performance index are used to assess aspects of systolic and diastolic function in adult as well as fetal heart. The Tei Index (TI) is a useful and non-invasive tool. The aim of this study was to determine normal values of fetal left ventricular (LV) TI in early (16-32 weeks) and late trimester (35-41 weeks) fetuses and to develop a new myocardial performance index (K-index; KI) which focuses on fetal diastolic interval when oxygenated blood from the placenta filled in the LV. Simultaneous recordings of Doppler Ultrasound Signal (DUS) of the LV outflow tracts and fetal electrocardiogram signals were obtained in 55 early- and late-trimester fetuses...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28320373/nelumbo-nucifera-leaves-extracts-inhibit-mouse-airway-smooth-muscle-contraction
#8
Xiao Yang, Lu Xue, Qingyang Zhao, Congli Cai, Qing-Hua Liu, Jinhua Shen
BACKGROUND: Alkaloids extracted from lotus leaves (AELL) can relax vascular smooth muscle. However, whether AELL has a similar relaxant role on airway smooth muscle (ASM) remains unknown. This study aimed to explore the relaxant property of AELL on ASM and the underlying mechanism. METHODS: Alkaloids were extracted from dried lotus leaves using the high temperature rotary evaporation extraction method. The effects of AELL on mouse ASM tension were studied using force measuring and patch-clamp techniques...
March 20, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28317837/inhibitory-responses-mediated-by-vagal-nerve-stimulation-are-diminished-in-stomachs-of-mice-with-reduced-intramuscular-interstitial-cells-of-cajal
#9
Elizabeth A H Beckett, Kenton M Sanders, Sean M Ward
Intramuscular interstitial cells of Cajal (ICC-IM) are closely associated with enteric motor nerve terminals and electrically coupled to smooth muscle cells within the gastric musculature. Previous studies investigating the role of ICC-IM in motor neurotransmission have used indiscriminate electric field stimulation of neural elements within the gastric wall. To determine the role of ICC-IM in transduction of vagally-mediated motor input to gastric muscles electrical and mechanical responses to selective electrical vagal stimulation (EVS) were recorded from gastric fundus and antral regions of wild type and W/W(V) mice, which lack most ICC-IM...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28315343/inhibition-of-agonist-induced-smooth-muscle-contraction-by-picotamide-in-the-male-human-lower-urinary-tract-outflow-region
#10
Martin Hennenberg, Alexander Tamalunas, Yiming Wang, Patrick Keller, Melanie Schott, Frank Strittmatter, Annika Herlemann, Qingfeng Yu, Beata Rutz, Anna Ciotkowska, Christian G Stief, Christian Gratzke
Male lower urinary tract symptoms (LUTS) due to bladder outlet obstruction are characterized by abnormal smooth muscle contractions in the lower urinary tract. Alpha1-adrenoceptor antagonists may induce smooth muscle relaxation in the outflow region and represent the current goldstandard of medical treatment. However, results may be unsatisfactory or inadequate. Apart from α1-adrenoceptor agonists, smooth muscle contraction in the outflow region may be induced by thromboxane A2 (TXA2), endothelins, or muscarinic receptor agonists...
March 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28314055/localization-of-muscle-damage-within-the-quadriceps-femoris-induced-by-different-types-of-eccentric-exercises
#11
Sumiaki Maeo, Akira Saito, Shun Otsuka, Xiyao Shan, Hiroaki Kanehisa, Yasuo Kawakami
This study examined localization of muscle damage within the quadriceps femoris induced by different types of eccentric exercises by using transverse relaxation time (T2 )-weighted magnetic resonance imaging (MRI). Thirty-three young males performed either of the following three exercises: single-joint eccentric contraction of the knee extensors (KE), eccentric squat (S), or downhill walking (DW) (n=11/exercise). KE and S consisted of 5-set × 10-lowering of 90% one-repetition maximum load. DW was performed for 60 min with -10% slope, 6 km/h velocity, and 20% body mass load carried...
March 17, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28303719/pentanuclear-lanthanide-mono-organophosphates-synthesis-structure-and-magnetism
#12
Sandeep K Gupta, Stuart K Langley, Kamna Sharma, Keith S Murray, Ramaswamy Murugavel
Research on rare-earth phosphates has recently received substantial interest because of their unique physical and chemical properties. In recent years, because of their low solubility, research interest has been built on developing methodologies to prepare nanostructures and grow single crystals of inorganic rare-earth phosphates. The chemistry of rare-earth organophosphates, however, is still at a latent stage. Contrary to the traditional hydrothermal route, we report rare examples of discrete pentanuclear lanthanide(III) organophosphate clusters assembled from a sterically encumbered monoester of phosphoric acid under mild reaction conditions...
March 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28303627/camp-dependent-regulation-of-rhoa-rho-kinase-attenuates-detrusor-overactivity-in-a-novel-mouse-experimental-model
#13
William Akakpo, Biljana Musicki, Arthur L Burnett
OBJECTIVES: To investigate detrusor function and cAMP activation as a possible target for detrusor overactivity in an experimental model lacking a key denitrosylation enzyme, S-nitrosoglutathione reductase (GSNOR). MATERIALS AND METHODS: GSNOR-deficient (GSNOR(-/-) ) (n=30) and wild-type (WT) mice (n=26) were treated for 7 days with the cAMP activator, colforsin (1mg/kg), or vehicle intraperitoneally. Cystometric studies or molecular analyses of bladder specimens were performed...
March 16, 2017: BJU International
https://www.readbyqxmd.com/read/28302929/heartworm-extract-induces-relaxation-of-isolated-rat-thoracic-aorta
#14
Katsuya Kitoh, Hiroaki Nakamura, Hitoshi Kitagawa, Toshihiro Unno, Seiichi Komori, Shin-Pin Chiou, Yasuhiro Takashima
Isolated rat thoracic aortic strips undergoing noradrenaline-induced contraction were treated with an adult heartworm (HW) crude extract and then examined for isometric changes in tension. HW extract caused relaxation of endothelium-intact strips, but not endothelium-denuded strips. This effect was inhibited by treatment with N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME) and could be reversed by additional treatment with L-arginine. However, HW extract at a high concentration caused slight relaxation of endothelium-denuded strips, and relaxation persisted after L-NAME treatment in endothelium intact-strips...
March 8, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28298655/dual-nep-ece-inhibition-improves-endothelial-function-in-mesenteric-resistance-arteries-of-32-week-old-shr
#15
Pieter Lemkens, Leon Ja Spijkers, Merlijn J Meens, Jelly Nelissen, Ben Janssen, Stephan Lm Peters, Paul Mh Schiffers, Jo Gr De Mey
Endothelin 1 (ET-1), a potent vasoconstrictor, pro-mitogenic and pro-inflammatory peptide, may promote development of endothelial dysfunction and arterial remodeling. ET-1 can be formed through cleavage of big-ET-1 by endothelin-converting enzyme (ECE) or neutral endopeptidase (NEP). We investigated whether chronic treatment with the novel dual NEP/ECE inhibitor SOL1 improves functional and structural properties of resistance-sized arteries of 32-week-old male spontaneously hypertensive rats (SHR). SHR received a chronic 4-week treatment with SOL1, losartan or hydralazine...
March 16, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28297896/shear-viscosity-of-a-two-dimensional-emulsion-of-drops-using-a-multiple-relaxation-time-step-lattice-boltzmann-method
#16
I Halliday, X Xu, K Burgin
An extended Benzi-Dellar lattice Boltzmann equation scheme [R. Benzi, S. Succi, and M. Vergassola, Europhys. Lett. 13, 727 (1990)EULEEJ0295-507510.1209/0295-5075/13/8/010; R. Benzi, S. Succi, and M. Vergassola, Phys. Rep. 222, 145 (1992)PRPLCM0370-157310.1016/0370-1573(92)90090-M; P. J. Dellar, Phys. Rev. E 65, 036309 (2002)1063-651X10.1103/PhysRevE.65.036309] is developed and applied to the problem of confirming, at low Re and drop fluid concentration, c, the variation of effective shear viscosity, η_{eff}=η_{1}[1+f(η_{1},η_{2})c], with respect to c for a sheared, two-dimensional, initially crystalline emulsion [here η_{1} (η_{2}) is the fluid (drop fluid) shear viscosity]...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28296232/inhibitors-of-soluble-epoxide-hydrolase-minimize-ischemia-reperfusion-induced-cardiac-damage-in-normal-hypertensive-and-diabetic-rats
#17
Oliul Islam, Prashanth Patil, Sumanta K Goswami, Rema Razdan, Mohammed N Inamdar, Mohammed Rizwan, Jubin Mathew, Bora Inceoglu, Kin S Stephen Lee, Sung H Hwang, Bruce D Hammock
AIM: We designed a study to evaluate the cardioprotective effect of two soluble epoxide hydrolase (sEH) inhibitors, 1-(1-propanoylpiperidin-4-yl)-3-(4-trifluoromethoxy)phenyl)urea (TPPU) and trans-4-{4-[3-(4-trifluoromethoxyphenyl)-ureido]cyclohexyloxy}benzoic acid (t-TUCB), in ischemia-reperfusion (IR) model. METHODS: Cardioprotective effects of the sEH inhibitors were evaluated against IR-induced myocardial damage in hearts from normal, hypertensive and diabetic rats using Langendorff's apparatus...
March 15, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28295792/biventricular-impact-of-mild-to-moderate-pulmonary-valve-stenosis-in-fetal-life
#18
L Guirado, F Crispi, N Masoller, M Bennasar, E Marimon, J Carretero, E Gratacós, J M Martínez, M K Friedberg, O Gómez
OBJECTIVES: to define the pattern of fetal echocardiographic changes associated with isolated pulmonary valve stenosis (PS) and to correlate the echocardiographic findings with the neonatal outcome and the need of postnatal pulmonary valvuloplasty within the first 12 months of life. METHODS: a prospective cohort study was designed on 16 fetuses with isolated PS and 48 controls matched by gestational age at scan (+/- 2 weeks). Fetal standard ultrasound and comprehensive echocardiography, which included cardiovascular morphometric parameters, systolic and diastolic functional and timing-measurements, were performed in all cases...
March 10, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28295256/visualization-of-stimulus-specific-heterogeneous-activation-of-individual-vascular-smooth-muscle-cells-in-aortic-tissues
#19
Satoshi Komatsu, Toshio Kitazawa, Mitsuo Ikebe
Intercellular communication among autonomic nerves, endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) plays a central role in an uninterrupted regulation of blood flow through vascular contractile machinery. Impairment of this communication is linked to development of vascular diseases such as hypertension, cerebral/coronary vasospasms, aortic aneurism, and erectile dysfunction. Although the basic concept of the communication as a whole has been studied, the spatiotemporal correlation of ECs/VSMCs in tissues at the cellular level is unknown...
March 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28294531/tyrphostin-ag556-increases-the-activity-of-large-conductance-ca-2-activated-k-channels-by-inhibiting-epidermal-growth-factor-receptor-tyrosine-kinase
#20
Yan Wang, Hai-Ying Sun, Ying-Guang Liu, Zheng Song, Gang She, Guo-Sheng Xiao, Yan Wang, Gui-Rong Li, Xiu-Ling Deng
The present study was designed to investigate whether large conductance Ca(2+) -activated K(+) (BK) channels were regulated by epidermal growth factor (EGF) receptor (EGFR) tyrosine kinase. BK current and channel tyrosine phosphorylation level were measured in BK-HEK 293 cells expressing both functional α-subunits and the auxiliary β1-subunits using electrophysiology, immunoprecipitation and Western blotting approaches, respectively, and the function of rat cerebral basilar arteries was determined with a wire myography system...
March 14, 2017: Journal of Cellular and Molecular Medicine
keyword
keyword
53599
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"