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https://www.readbyqxmd.com/read/29792267/isotonic-fluids-for-volume-resuscitation-is-it-really-6-liters-of-one-half-a-dozen-of-another
#1
Christina M Wyatt, T Alp Ikizler
No abstract text is available yet for this article.
June 2018: Kidney International
https://www.readbyqxmd.com/read/29791910/melatonin-attenuates-histopathological-changes-in-the-hippocampus-of-infantile-rats-with-kaolin-induced-hydrocephalus
#2
Mehmet Turgut, Meral Baka, Yiğit Uyanıkgil
OBJECTIVE/AIM: Hydrocephalus is defined as an incapacitating neurological disorder characterized by ventricular enlargement in children, but the effects of melatonin on this hydrocephalus have not yet been fully elucidated. In the present experiment, we attempted to investigate the effects of exogenous melatonin administration on hydrocephalus-induced hippocampal changes in infantile rats. METHODS: In this study, we randomly divided 45 Swiss albino rats aged 2 weeks into 3 groups: group I, the control group received a sham injection with needle insertion only; groups II and III were given kaolin injections before treatment - group II, the hydrocephalus group, was treated with an isotonic NaCl solution, and group III, the hydrocephalus plus melatonin group, was treated with 0...
May 23, 2018: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29781009/electrically-controlled-drug-release-using-ph-sensitive-polymer-films
#3
S Ephraim Neumann, Christian F Chamberlayne, Richard N Zare
Drug delivery systems (DDS) that allow spatially and temporally controlled release of drugs are of particular interest in the field of drug delivery. These systems create opportunities for individually tailored doses of drugs to be administered as well as reduce side effects by localizing the initial drug dose to the organ of interest. We present an electroresponsive DDS in the form of a bioresorbable nanocomposite film which operates at low voltages (<-2 V). The method is based on electrochemically generating local pH changes at an electrode surface to induce dissolution of a pH-sensitive polymer, which is used as the carrier material...
May 21, 2018: Nanoscale
https://www.readbyqxmd.com/read/29778118/erratum
#4
(no author information available yet)
METHODS: …The systems were the Paracel/Vibex Xtra, comprising riboflavin 0.25% solution containing TRIS and ethylenediaminetetraacetic acid and an isotonic solution of riboflavin 0.25%, (Group 1) and the CXLO system (Group 2)…. RESULTS: The mean riboflavin fluorescence intensity grades in Group 2 (4 eyes) were 3.8, 4.8, and 4.8 at 10, 15, and 20 minutes, respectively. The mean grades in Group 1 (3 eyes) were 2.0, 2.3, and 2.0, respectively. The riboflavin distribution was uniform in Group 2 but not in Group 1...
April 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29774747/hypertonic-saline-versus-isotonic-saline-nasal-irrigation-systematic-review-and-meta-analysis
#5
Dichapong Kanjanawasee, Kachorn Seresirikachorn, Wirach Chitsuthipakorn, Kornkiat Snidvongs
Background Saline nasal lavage is one of the treatments of sinonasal diseases. Evidence from basic research favors hypertonic saline (HS) over isotonic saline (IS) for mucociliary clearance, but evidence from clinical studies is controversial. Conversely, HS may carry greater side effects. Objective To compare the effects of HS and IS nasal irrigation in treating sinonasal diseases. Methods Systematic search with Ovid MEDLINE, Scopus, PubMed, Google Scholar, and Manual additional sources was conducted. Randomized controlled trials comparing HS with IS nasal irrigation in treating any sinonasal diseases, including rhinitis and rhinosinusitis, were included...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29771807/administration-of-an-oral-hydration-solution-prevents-electrolyte-and-fluid-disturbances-and-reduces-readmissions-in-patients-with-a-diverting-ileostomy-after-colorectal-surgery-a-prospective-randomized-controlled-trial
#6
Athanasios Migdanis, Georgios Koukoulis, Ioannis Mamaloudis, Ioannis Baloyiannis, Ioannis Migdanis, Maria Kanaki, Eleni Malissiova, Georgios Tzovaras
BACKGROUND: Patients with a newly formed ileostomy often develop electrolyte abnormalities and dehydration. OBJECTIVE: The study assessed the prophylactic effect of an isotonic hydration solution on dehydration and electrolyte abnormalities in patients with a newly formed ileostomy. DESIGN: This was a prospective, randomized, controlled trial (NCT02036346). SETTINGS: The study was conducted at a single surgical unit of a public university hospital...
May 15, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29770709/lessons-learned-from-the-preserve-trial
#7
Sasan Partovi, Thomas Trischman, Preet S Kang
The recently published PRESERVE trial is presently the largest and most comprehensive clinical trial comparing commonly applied strategies for prevention of iodinated contrast-induced acute kidney injury in high-risk patients. The fundamental conclusion of the PRESERVE trial is that oral acetylcysteine and intravenous sodium bicarbonate are not superior to simple intravenous hydration with isotonic saline for the prevention of contrast-induced renal sequelae. In this commentary, we discuss the results in the context of selected past major trials, and provide insights into the strengths and potential weaknesses of the PRESERVE trial...
May 17, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29756867/strong-neutron-pairing-in-core-4n-nuclei
#8
A Revel, F M Marqués, O Sorlin, T Aumann, C Caesar, M Holl, V Panin, M Vandebrouck, F Wamers, H Alvarez-Pol, L Atar, V Avdeichikov, S Beceiro-Novo, D Bemmerer, J Benlliure, C A Bertulani, J M Boillos, K Boretzky, M J G Borge, M Caamaño, E Casarejos, W N Catford, J Cederkäll, M Chartier, L Chulkov, D Cortina-Gil, E Cravo, R Crespo, U Datta Pramanik, P Díaz Fernández, I Dillmann, Z Elekes, J Enders, O Ershova, A Estradé, F Farinon, L M Fraile, M Freer, D Galaviz, H Geissel, R Gernhäuser, P Golubev, K Göbel, J Hagdahl, T Heftrich, M Heil, M Heine, A Heinz, A Henriques, A Ignatov, H T Johansson, B Jonson, J Kahlbow, N Kalantar-Nayestanaki, R Kanungo, A Kelic-Heil, A Knyazev, T Kröll, N Kurz, M Labiche, C Langer, T Le Bleis, R Lemmon, S Lindberg, J Machado, J Marganiec, A Movsesyan, E Nacher, M Najafi, T Nilsson, C Nociforo, S Paschalis, A Perea, M Petri, S Pietri, R Plag, R Reifarth, G Ribeiro, C Rigollet, M Röder, D Rossi, D Savran, H Scheit, H Simon, I Syndikus, J T Taylor, O Tengblad, R Thies, Y Togano, P Velho, V Volkov, A Wagner, H Weick, C Wheldon, G Wilson, J S Winfield, P Woods, D Yakorev, M Zhukov, A Zilges, K Zuber
The emission of neutron pairs from the neutron-rich N=12 isotones ^{18}C and ^{20}O has been studied by high-energy nucleon knockout from ^{19}N and ^{21}O secondary beams, populating unbound states of the two isotones up to 15 MeV above their two-neutron emission thresholds. The analysis of triple fragment-n-n correlations shows that the decay ^{19}N(-1p)^{18}C^{*}→^{16}C+n+n is clearly dominated by direct pair emission. The two-neutron correlation strength, the largest ever observed, suggests the predominance of a ^{14}C core surrounded by four valence neutrons arranged in strongly correlated pairs...
April 13, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29756268/does-rotational-thromboelastometry-accurately-predict-coagulation-status-in-patients-with-lupus-anticoagulant
#9
L Hensch, V Kostousov, K Bruzdoski, M Losos, M Pereira, M de Guzman, S Hui, J Teruya
INTRODUCTION: Rotational thromboelastometry (ROTEM) is increasingly used as a tool for monitoring coagulation status. However, ROTEM is susceptible to misinterpretation due to particular coagulation abnormalities. Here, we report the effects of lupus anticoagulant (LA) on ROTEM. METHODS: A prospective observational analysis was performed on 16 children with prior studies indicating the presence of LA or antiphospholipid antibodies. ROTEM analysis was performed, and samples were further analyzed by adding phospholipids (PL) to repeat ROTEM analysis if clotting time (CT) abnormalities were discovered with comparison to ROTEM using an equal volume of isotonic saline...
May 13, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29755322/microglial-activation-after-systemic-stimulation-with-lipopolysaccharide-and-escherichia-coli
#10
Inge C M Hoogland, Dunja Westhoff, Joo-Yeon Engelen-Lee, Jeroen Melief, Mercedes Valls Serón, Judith H M P Houben-Weerts, Inge Huitinga, David J van Westerloo, Tom van der Poll, Willem A van Gool, Diederik van de Beek
Background: Microglial activation after systemic infection has been suggested to mediate sepsis-associated delirium. A systematic review of animal studies suggested distinct differences between microglial activation after systemic challenge with live bacteria and lipopolysaccharide (LPS). Here, we describe a mouse model of microglial activation after systemic challenge with live Escherichia coli ( E. coli ) and compare results with systemic challenge with LPS. Methods: Sixty mice were intraperitoneally injected with E...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29740578/using-electrolyte-free-water-balance-to-rationalize-and-treat-dysnatremias
#11
REVIEW
Sanjeev R Shah, Gautam Bhave
Dysnatremias or abnormalities in plasma [Na+ ] are often termed disorders of water balance, an unclear physiologic concept often confused with changes in total fluid balance. However, most clinicians clearly recognize that hypertonic or hypotonic gains or losses alter plasma [Na+ ], while isotonic changes do not modify plasma [Na+ ]. This concept can be conceptualized as the electrolyte free water balance (EFWB), which defines the non-isotonic components of inputs and outputs to determine their effect on plasma [Na+ ]...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29735916/improving-cull-cow-meat-quality-using-vacuum-impregnation
#12
Martha Y Leal-Ramos, Alma D Alarcón-Rojo, Néstor Gutiérrez-Méndez, Hugo Mújica-Paz, Felipe Rodríguez-Almeida, Armando Quintero-Ramos
Boneless strip loins from mature cows (50 to 70 months of age) were vacuum impregnated (VI) with an isotonic solution (IS) of sodium chloride. This study sought to determine the vacuum impregnation and microstructural properties of meat from cull cows. The experiments were conducted by varying the pressure, p 1 (20.3, 71.1 kPa), and time, t 1 (0.5, 2.0, 4.0 h), of impregnation. After the VI step, the meat was kept for a time, t 2 (0.0, 0.5, 2.0, 4.0 h), in the IS under atmospheric pressure. The microstructural changes, impregnation, deformation, and porosity of the meat were measured in all the treatments...
May 7, 2018: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29733059/citotoxicidad-de-soluciones-recomendadas-para-el-almacenamiento-de-dientes-avulsionados-en-cultivo-con-c%C3%A3-lulas-del-ligamento-periodontal
#13
Galia Cruz-Durán, Raúl Ortiz-Daza Raúl, Jacinto Armando Díaz-Acevedo, Benjamín Sánchez-Trocino, Ma Concepción Arenas-Arrocena, René García-Contreras
Introducción: El medio de almacenamiento de los dientes avulsionados hasta su reimplante es vital para conservar los fibroblastos del ligamento periodontal humano (HPLF). Objetivo: Comparar el efecto citotóxico para conservar los HPLF de la leche y la solución isotónica para almacenamiento de dientes avulsionados. Método: Se realizó subcultivo de fibroblastos del ligamento periodontal con una densidad de 1:2 (3 × 105 células/mL), que fueron incubados por 48 horas...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29728805/large-volume-crystalloid-fluid-is-associated-with-increased-hyaluronan-shedding-and-inflammation-in-a-canine-hemorrhagic-shock-model
#14
Lisa Smart, C J Boyd, M A Claus, E Bosio, G Hosgood, A Raisis
Shedding of the endothelial glycocalyx precedes leukocyte activation and adherence in acute inflammation. Rapid administration of crystalloid or colloid fluids for treating hemorrhagic shock may cause endothelial glycocalyx shedding, thereby increasing inflammation. This study aimed to compare the effect of different fluid treatments in a canine shock model on glycocalyx biomarker, hyaluronan, and inflammatory biomarkers. Greyhound dogs under general anesthesia subject to hemorrhage for 60 min were given 20 mL kg-1 of either fresh whole blood (FWB), hydroxyethyl starch (HES) 130/0...
May 4, 2018: Inflammation
https://www.readbyqxmd.com/read/29728739/decreased-contraction-induced-by-endothelium-derived-contracting-factor-in-prolonged-treatment-of-rat-renal-artery-with-endoplasmic-reticulum-stress-inducer
#15
Makoto Ando, Takayuki Matsumoto, Kumiko Taguchi, Tsuneo Kobayashi
Recent evidence suggests that endoplasmic reticulum (ER) stress is involved in the regulation of various physiological functions, including those of the vascular system. However, the relationship between ER stress and vascular function is poorly understood. The endothelial cells control the vascular tone by releasing endothelium-derived relaxing factors and contracting factors (EDCFs). We hypothesized that tunicamycin, an inducer of ER stress, modifies endothelium-dependent contraction and prostaglandins (PGs), a major class of EDCFs, induced contractions in the rat renal artery in rats...
May 4, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29723252/test-retest-reliability-of-knee-extensor-rate-of-velocity-and-power-development-in-older-adults-using-the-isotonic-mode-on-a-biodex-system-3-dynamometer
#16
Stijn Van Driessche, Evelien Van Roie, Benedicte Vanwanseele, Christophe Delecluse
Isotonic testing and measures of rapid power production are emerging as functionally relevant test methods for detection of muscle aging. Our objective was to assess reliability of rapid velocity and power measures in older adults using the isotonic mode of an isokinetic dynamometer. Sixty-three participants (aged 65 to 82 years) underwent a test-retest protocol with one week time interval. Isotonic knee extension tests were performed at four different loads: 0%, 25%, 50% and 75% of maximal isometric strength...
2018: PloS One
https://www.readbyqxmd.com/read/29709069/predicting-suicide-attempts-in-adolescents-with-longitudinal-clinical-data-and-machine-learning
#17
Colin G Walsh, Jessica D Ribeiro, Joseph C Franklin
BACKGROUND: Adolescents have high rates of nonfatal suicide attempts, but clinically practical risk prediction remains a challenge. Screening can be time consuming to implement at scale, if it is done at all. Computational algorithms may predict suicide risk using only routinely collected clinical data. We used a machine learning approach validated on longitudinal clinical data in adults to address this challenge in adolescents. METHODS: This is a retrospective, longitudinal cohort study...
April 30, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29705974/extreme-hypercalcemia-in-a-kidney-transplant-recipient
#18
Erol Demir, Cagla Karaoglan, Gulcin Yegen, Betul Sair, Halil Yazici, Aydin Turkmen, Mehmet Sukru Sever
Post-transplant hypercalcemia is a major problem in renal transplant recipients, which may negatively affect both graft and patient survival. In this paper, we present a 66-year-old male kidney transplant recipient, who was admitted to our clinic with symptoms of fever, nausea, vomiting and lethargy. Laboratory data showed good renal function; however, a serum calcium level of 22.1 mg/dL. The patient was treated by isotonic saline together with furosemide and methylprednisolone. Because of treatment resistance, subcutaneous calcitonin and ibandronate were added to the treatment protocol as well...
April 28, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29705499/high-salt-intake-increases-plasma-trimethylamine-n-oxide-tmao-concentration-and-produces-gut-dysbiosis-in-rats
#19
Klaudia Bielinska, Marek Radkowski, Marta Grochowska, Karol Perlejewski, Tomasz Huc, Kinga Jaworska, Daisuke Motooka, Shota Nakamura, Marcin Ufnal
OBJECTIVE: A high-salt diet is considered a cardiovascular risk factor; however, the mechanisms are not clear. Research suggests that gut bacteria-derived metabolites such as trimethylamine N-oxide (TMAO) are markers of cardiovascular diseases. We evaluated the effect of high salt intake on gut bacteria and their metabolites plasma level. METHODS: Sprague Dawley rats ages 12-14 wk were maintained on either water (controls) or 0.9% or 2% sodium chloride (NaCl) water solution (isotonic and hypertonic groups, respectively) for 2 wk...
March 22, 2018: Nutrition
https://www.readbyqxmd.com/read/29698107/power-reserve-following-ramp-incremental-cycling-to-exhaustion-implications-for-muscle-fatigue-and-function
#20
Michael D Hodgson, Daniel A Keir, David B Copithorne, Charles L Rice, John M Kowalchuk
In ramp-incremental cycling exercise, some individuals are capable of producing power output (PO) in excess of that produced at their limit of tolerance (LoT) while others cannot. This study sought to describe the: 1) prevalence of a "power reserve" within a group of young men (n=21; mean {plus minus} SD: age 25{plus minus}4 years; V̇O2max 45{plus minus}8 ml•kg-1 •min-1 ); and 2) muscle fatigue characteristics of those with and without a power reserve. Power reserve was determined as the difference between peak PO achieved during a ramp-incremental test to exhaustion and maximal, single-leg isokinetic dynamometer power...
April 26, 2018: Journal of Applied Physiology
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