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https://www.readbyqxmd.com/read/28624288/short-communication-behavioral-evaluation-of-the-analgesic-effect-of-flunixin-meglumine-in-lame-dairy-cows
#1
S A Wagner, J M Young, J K Tena, B H Manning
The objective of this study was to evaluate the effect of flunixin meglumine treatment on lameness pain in dairy cows. Twenty-four lactating Holstein cows were enrolled in the study based on visual observation of abnormal locomotion. The primary measurement endpoint was weight-shifting between the rear limbs. Weight-shifting was calculated as the standard deviation of the weight borne on the rear limbs over a 15 min period; this value correlates directly with lameness pain in dairy cows. After collecting baseline weight-bearing data, we randomly assigned cows to 1 of 2 treatment groups: 2...
June 14, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28616032/dose-dependent-neuroprotective-effect-of-enoxaparin-on-cold-induced-traumatic-brain-injury
#2
Ilknur Keskin, M Yalcin Gunal, Nilufer Ayturk, Ulkan Kilic, Mehmet Ozansoy, Ertugrul Kilic
Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after modeling, male BALB/c mouse models of cold-induced traumatic brain injury were intraperitoneally administered 3 and 10 mg/kg enoxaparin or isotonic saline solution. Twenty-four hours later, enoxaparin at 10 mg/kg greatly reduced infarct volume, decreased cell apoptosis in the cortex and obviously increased serum level of total antioxidant status...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28615883/clinicobiochemical-changes-in-ivermectin-toxicity-in-doberman-pinscher-pups
#3
Sahadeb Dey, Nitin P Kurade, Kishore Lal Khurana, Ananya Dan
This study is based on naturally intoxicated Doberman pinscher pups. Six Doberman pinscher pups were overdosed 50 times of recommended ivermectin dose by the pet owner and presented to Referral Veterinary Polyclinic section of this institute in a state of coma. The pups were unable to hold their head up and had no pupillary reflex. The pups were examined clinically and samples of blood were taken for haemato-biochemical studies, before and after treatment. During intoxication there was marked haemoconcentration, increase in values of serum creatinine phosphokinase, gamma glutamyl transpeptidase but decrease in serum glucose levels...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28614720/cellular-stress-in-the-context-of-an-inflammatory-environment-supports-tgf-%C3%AE-independent-t-helper-17-differentiation
#4
Verena Brucklacher-Waldert, Cristina Ferreira, Marisa Stebegg, Olivier Fesneau, Silvia Innocentin, Julien C Marie, Marc Veldhoen
T helper-17 (Th17) cells are associated with inflammatory disorders and cancer. We report that environmental conditions resulting in cellular stress, such as low oxygen, glucose, and isotonic stress, particularly enhance the generation of Th17 cells. Pharmacological inhibition of cell stress reduces Th17 cell differentiation while stress inducers enhance the development of Th17 cells. The cellular stress response results in Th17 cell development via sustained cytoplasmic calcium levels and, in part, XBP1 activity...
June 13, 2017: Cell Reports
https://www.readbyqxmd.com/read/28603044/relaxation-of-isolated-guinea-pig-trachea-by-apigenin-a-constituent-of-celery-via-inhibition-of-phosphodiesterase
#5
Junn-Lain Chen, Wun-Chang Ko
Apigenin, was reported to have vasodilatory effects by inhibiting Ca(2+) influx through both voltage- and receptor-operated calcium channels, but not by inhibiting cAMP- or cGMP-phosphodiesterases (PDEs) in rat thoracic aorta. However, apigenin was reported to inhibit PDE1, 2 and 3 in guinea-pig lung and heart. The aim of this study was to clarify that guinea-pig tracheal relaxation by apigenin whether via PDE inhibition. We isometrically recorded the tension of isolated guinea-pig tracheal segments on a polygraph...
June 9, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28602669/the-selective-cytotoxicity-of-new-triazene-compounds-to-human-melanoma-cells
#6
Ana Sousa, Fábio Santos, Maria Manuela Gaspar, Susana Calado, João D Pereira, Eduarda Mendes, Ana Paula Francisco, Maria Jesus Perry
Metastatic melanoma still remains one the most difficult cancers to overcome. The aim of our research was the design of anti-tumour triazene compounds 3 for application to a melanoma-specific therapy. The strategy exploits the unique enzyme pathway of melanin biosynthesis for conversion of non-toxic prodrugs into toxic drugs in the melanoma cell. The compounds 3 were designed by coupling two active moieties, the alkylating triazenes and different tyrosinase substrates. All compounds 3 revealed to be chemically stable in isotonic phosphate buffer (PBS) at physiologic pH (t½≥48h), and most of them showed to be slowly hydrolysed in human plasma (1...
May 31, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28591080/muscle-pain-induces-a-shift-of-the-spatial-distribution-of-upper-trapezius-muscle-activity-during-a-repetitive-task-a-mechanism-for-perpetuation-of-pain-with-repetitive-activity
#7
Deborah Falla, Corrado Cescon, Rene Lindstroem, Marco Barbero
OBJECTIVE: An association exists between repetitive movements and neck-shoulder muscle pain. The mechanisms underlying this association remain unclear. This observational study investigated the effect of upper trapezius muscle pain on the distribution of upper trapezius activity during repetitive lifting. It was hypothesized that nociception would change the distribution of activity resulting in activation of muscle regions which would not normally be active during the task. MATERIALS AND METHODS: Healthy men repeatedly lifted a box with a cycle time of 3 seconds for 50 cycles, at baseline, following injection of isotonic and hypertonic saline into the upper trapezius muscle and 15 minutes after the last injection...
June 6, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28585671/effects-of-intrathecal-caffeic-acid-phenethyl-ester-cape-on-il-6-and-tnf-%C3%AE-levels-and-local-inflammatory-responses-in-spinal-cord-injuries
#8
Bekir Akgün, Sait Ozturk, Gokhan Artas, Fatih Serhat Erol
AIM: To investigate the effects of intrathecal caffeic acid phenethyl ester (CAPE) on tissue and serum IL-6 and TNF-α levels following spinal cord injury (SCI) as well as its effects on edema and microhemorrage. MATERIAL AND METHODS: Forty rats were divided into four groups. The sham group underwent single-level laminectomy and then received an intrathecal injection of isotonic saline. The control group received an intrathecal injection of isotonic saline following SCI induction...
April 27, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28584973/from-single-muscle-fiber-to-whole-muscle-mechanics-a-finite-element-model-of-a-muscle-bundle-with-fast-and-slow-fibers
#9
Lorenzo Marcucci, Carlo Reggiani, Arturo N Natali, Piero G Pavan
Muscles exhibit highly complex, multi-scale architecture with thousands of muscle fibers, each with different properties, interacting with each other and surrounding connective structures. Consequently, the results of single-fiber experiments are scarcely linked to the macroscopic or whole muscle behavior. This is especially true for human muscles where it would be important to understand of how skeletal muscles disorders affect patients' life. In this work, we developed a mathematical model to study how fast and slow muscle fibers, well characterized in single-fiber experiments, work and generate together force and displacement in muscle bundles...
June 5, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28583486/ototoxicity-associated-with-topical-administration-of-diclofenac-sodium-as-an-otic-drop-an-experimental-animal-study
#10
Engin Acioglu, Ozgur Yigit, Firat Onur, Ahmet Atas, Ela Araz Server, Eyup Kara
OBJECTIVES: The aim of the study is to evaluate the ototoxicity of topical diclofenac sodium in comparison to positive and negative controls prior to the investigation of analgesic and anti-inflammatory efficacy of the agent in otic administration. METHODS: Twenty four ears of 12 guinea pigs were included in the study. Wide myringotomy was performed on all tympanic membranes under general anesthesia and auditory brainstem responses (ABR) were evaluated. The subjects were separated into four groups, two groups received diclofenac sodium at low and high doses, positive controls received gentamicin and negative controls received isotonic sodium chloride topically for 14 days and ABRs were reevaluated...
July 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28579960/modeling-the-mechanics-of-cell-division-influence-of-spontaneous-membrane-curvature-surface-tension-and-osmotic-pressure
#11
Elena Beltrán-Heredia, Víctor G Almendro-Vedia, Francisco Monroy, Francisco J Cao
Many cell division processes have been conserved throughout evolution and are being revealed by studies on model organisms such as bacteria, yeasts, and protozoa. Cellular membrane constriction is one of these processes, observed almost universally during cell division. It happens similarly in all organisms through a mechanical pathway synchronized with the sequence of cytokinetic events in the cell interior. Arguably, such a mechanical process is mastered by the coordinated action of a constriction machinery fueled by biochemical energy in conjunction with the passive mechanics of the cellular membrane...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28571238/analgesic-effect-of-intra-articular-morphine-or-dexmedetomidine-added-with-levobupivacaine-in-arthroscopic-knee-surgeries-a-comparative-evaluation
#12
Rajat Kumar Agarwal, Yashwant Singh Payal, Gaurav Chopra, Atul Agrawal
INTRODUCTION: Knee arthroscopy is associated with variable amount of postoperative pain. In an attempt to improve postoperative analgesia, intra-articular injection of local anaesthetic in combination with other agent have been studied. However, the best combination is not known. AIM: To compare the analgesic efficacy of intra-articular injection of morphine and dexmedetomidine when added with levobupivacaine in arthroscopic knee surgeries. MATERIALS AND METHODS: Seventy eight patients, scheduled to undergo elective arthroscopic procedure under spinal anaesthesia were recruited for the study...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28558734/the-effects-of-arthritis-gloves-on-people-with-rheumatoid-arthritis-or-inflammatory-arthritis-with-hand-pain-a-study-protocol-for-a-multi-centre-randomised-controlled-trial-the-a-gloves-trial
#13
Yeliz Prior, Chris Sutton, Sarah Cotterill, Jo Adams, Elizabeth Camacho, Nazina Arafin, Jill Firth, Terence O'Neill, Yvonne Hough, Wendy Jones, Alison Hammond
BACKGROUND: Arthritis gloves are regularly provided as part of the management of people with rheumatoid arthritis (RA) and undifferentiated (early) inflammatory arthritis (IA). Usually made of nylon and elastane (i.e. Lycra®), these arthritis gloves apply pressure with the aims of relieving hand pain, stiffness and improving hand function. However, a systematic review identified little evidence supporting their use. We therefore designed a trial to compare the effectiveness of the commonest type of arthritis glove provided in the United Kingdom (Isotoner gloves) (intervention) with placebo (control) gloves (i...
May 30, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28535058/peo-ppo-diblock-copolymers-protect-myoblasts-from-hypo-osmotic-stress-in-vitro-dependent-on-copolymer-size-composition-and-architecture
#14
Mihee Kim, Karen J Haman, Evelyne M Houang, Wenjia Zhang, Demetris Yannopoulos, Joseph M Metzger, Frank S Bates, Benjamin J Hackel
Poloxamer 188, a triblock copolymer of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), protects cellular membranes from various stresses. Though numerous block copolymer variants exist, evaluation of alternative architecture, composition, and size has been minimal. Herein, cultured murine myoblasts are exposed to the stresses of hypotonic shock and isotonic recovery, and membrane integrity was evaluated by quantifying release of lactate dehydrogenase. Comparative evaluation of a systematic set of PEO-PPO diblock and PEO-PPO-PEO triblock copolymers demonstrates that the diblock architecture can be protective in vitro...
June 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28532702/trimetazidine-in-the-prevention-of-contrast-induced-nephropathy-in-chronic-kidney-disease
#15
Tarek A Ibrahim, Ramzy H El-Mawardy, Ahmed S El-Serafy, Ehab M El-Fekky
BACKGROUND: Contrast induced nephropathy (CIN) may be defined as Acute Renal Failure (ARF) that occurs within 24-72h of exposure to intra-venous or intra-arterial iodinated contrast media that cannot be attributed to other causes. CIN occurs in up to 5% of hospitalized patients with normal renal function prior to injection of contrast media. It occurs more frequently in patients with renal impairment particularly if associated with diabetic nephropathy. Among all procedures utilizing contrast agents for either diagnostic or therapeutic purposes, coronary angiography and percutaneous coronary interventions are associated with the highest rates of CIN...
February 10, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28531577/the-effect-of-isotonic-drinks-on-electrolyte-abnormalities-of-ileostomy-patients-preliminary-results
#16
Antigoni Chalkia, Athanasios Migdanis, Georgios Koukoulis, Ioannis Mamaloudis, Ioannis Migdanis, Eleni Malisiova, Ioannis Gioulbasanis, Georgios Tzovaras
No abstract text is available yet for this article.
June 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28527424/influence-of-chronic-stretching-on-muscle-performance-systematic-review
#17
D M Medeiros, C S Lima
The aim of the current study was to investigate the influence of chronic stretching on muscle performance (MP) by a systematic review. The search strategy included MEDLINE, PEDro, Cochrane CENTRAL, LILACS, and manual search from inception to June 2016. Randomized and controlled clinical trials, non-randomized, and single group studies that have analyzed the influence of flexibility training (FT) (using any stretching technique) on MP were included. Differently, studies with special populations (children, elderly, and people with any dysfunction/disease), and articles that have used FT protocols shorter than three weeks or 12 sessions were excluded...
May 17, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28526694/measuring-osmosis-and-hemolysis-of-red-blood-cells
#18
Lauren K Goodhead, Frances M MacMillan
Since the discovery of the composition and structure of the mammalian cell membrane, biologists have had a clearer understanding of how substances enter and exit the cell's interior. The selectively permeable nature of the cell membrane allows the movement of some solutes and prevents the movement of others. This has important consequences for cell volume and the integrity of the cell and, as a result, is of utmost clinical importance, for example in the administration of isotonic intravenous infusions. The concepts of osmolarity and tonicity are often confused by students as impermeant isosmotic solutes such as NaCl are also isotonic; however, isosmotic solutes such as urea are actually hypotonic due to the permeant nature of the membrane...
June 1, 2017: Advances in Physiology Education
https://www.readbyqxmd.com/read/28526226/experimental-pain-in-the-groin-may-refer-into-the-lower-abdomen-implications-to-clinical-assessments
#19
M K Drew, T S Palsson, R P Hirata, M Izumi, G Lovell, M Welvaert, P Chiarelli, P G Osmotherly, T Graven-Nielsen
OBJECTIVES: To investigate the effects of experimental adductor pain on the pain referral pattern, mechanical sensitivity and muscle activity during common clinical tests. DESIGN: Repeated-measures design. METHODS: In two separate sessions, 15 healthy males received a hypertonic (painful) and isotonic (control) saline injection to either the adductor longus (AL) tendon to produce experimental groin pain or into the rectus femoris (RF) tendon as a painful control...
April 21, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28526086/comparison-of-fluid-balance-and-hemodynamic-and-metabolic-effects-of-sodium-lactate-versus-sodium-bicarbonate-versus-0-9-nacl-in-porcine-endotoxic-shock-a-randomized-open-label-controlled-study
#20
Thibault Duburcq, Arthur Durand, Anne-Frédérique Dessein, Joseph Vamecq, Jean-Claude Vienne, Dries Dobbelaere, Karine Mention, Claire Douillard, Patrice Maboudou, Valery Gmyr, François Pattou, Mercé Jourdain, Fabienne Tamion, Julien Poissy, Daniel Mathieu, Raphaël Favory
BACKGROUND: Sodium lactate has been shown to improve hemodynamics and avoid fluid overload. The objective of this study was to confirm a beneficial effect on fluid balance with sodium lactate infusion and to specify whether the advantage of lactate is related to a negative chloride balance, its particular metabolism, or simply its energy load. METHODS: This was an interventional, randomized, open-label, controlled experimental study. Fifteen female "large white" pigs (2 months old) were challenged with intravenous infusion of Escherichia coli endotoxin...
May 19, 2017: Critical Care: the Official Journal of the Critical Care Forum
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