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https://www.readbyqxmd.com/read/28077538/magnesium-sulphate-attenuates-acute-postoperative-pain-and-increased-pain-intensity-after-surgical-injury-in-staged-bilateral-total-knee-arthroplasty-a-randomized-double-blinded-placebo-controlled-trial
#1
H-J Shin, E-Y Kim, H-S Na, T K Kim, M-H Kim, S-H Do
BACKGROUND: We evaluated the effect of magnesium sulphate on increased pain in 44 patients undergoing staged bilateral total knee arthroplasty (TKA). METHODS: The magnesium group (n=22) and the control group (n=22) received magnesium sulphate and isotonic saline, respectively, throughout the surgery. Postoperative pain (visual analogue scale, VAS) at rest and the amounts of patient-controlled analgesia (PCA, fentanyl) and rescue analgesia (ketoprofen) administered during the first 48 h were compared between the two groups and within each group between the first and second TKA...
October 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28073414/-protective-effect-of-saccharomyces-boulardii-against-intestinal-mucosal-barrier-injury-in-rats-with-nonalcoholic-fatty-liver-disease
#2
Y T Liu, Y Q Li, Y Z Wang
Objective: To investigate the protective effect of Saccharomyces boulardii against intestinal mucosal barrier injury in rats with nonalcoholic fatty liver disease (NAFLD). Methods: A total of 36 healthy male Sprague-Dawley rats with a mean body weight of 180±20 g were randomly divided into control group, model group, and treatment group, with 12 rats in each group, after adaptive feeding for 1 week. The rats in the control group were given basic feed, and those in the model group and treatment group were given high-fat feed...
December 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28069899/lps-infusion-suppresses-serum-fgf21-levels-in-healthy-adult-volunteers
#3
Esben Stistrup Lauritzen, Nikolaj Rittig, Ermina Bach, Niels Moller, Mette Bjerre
CONTEXT: During the inflammatory acute phase response plasma glucose and serum triglycerides are increased in humans. Fibroblast growth factor (FGF) 21 has plasma glucose and lipid reducing actions, but its role in the acute inflammatory response in human is unknown. OBJECTIVE: To investigate circulating levels of FGF21 after lipopolysaccharide (LPS) infusion. DESIGN: Two randomized, single blinded, placebo-controlled crossover trials were used...
January 9, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28059870/epinephrine-deteriorates-pulmonary-gas-exchange-in-a-rat-model-of-bupivacaine-induced-cardiotoxicity-a-threshold-dose-of-epinephrine
#4
Quan-Guang Wang, Cong Wu, Yun Xia, Jiao-Jiao Dong, Ting-Ting Lin, Qiao-Yan Liu, Thomas J Papadimos, Xu-Zhong Xu
BACKGROUND AND OBJECTIVE: The study goal was to compare the effect of epinephrine in different doses on pulmonary gas exchange in a rat model of bupivacaine-induced cardiac depression. METHODS: Twenty-four adult male Sprague-Dawley rats were divided into 4 groups (n = 6), and each group received a bupivacaine infusion (2.5 mg/kg per minute, 6 minutes) via the left femoral vein to induce cardiac depression. At the end of the bupivacaine infusion, each group was immediately given either isotonic sodium chloride solution (normal saline; NS group), 5-μg/kg epinephrine (Epi5 group), 10-μg/kg epinephrine (Epi10 group), or 20 μg/kg epinephrine (Epi20 group)...
January 3, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28056233/-the-value-of-urinary-neutrophil-gelatinase-associated-lipocalin-for-early-diagnosis-of-contrast-induced-nephropathy
#5
W You, C L Qi, F Ye, S L Huang, D J Xie, Z M Wu, K Huang, K L Chen, T Y Huang, S L Chen
Objective: To explore the value of urinary neutrophil gelatinase-associated lipocalin (NGAL) for early diagnosis of contrast-induced nephropathy (CIN) in patients who underwent percutaneous coronary angiography (CAG) or percutaneous coronary intervention (PCI). Methods: From May 2015 to January 2016, 506 consecutive patients who underwent CAG or PCI in our hospital were enrolled in this prospective study. Patients were divided into CIN group (n=47) and non-CIN group (n=459). Clinical and interventional data were compared between the two groups...
December 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28049914/comparison-of-the-adsorption-of-original-and-biosimilar-preparations-of-filgrastim-on-infusion-sets-and-the-inhibition-of-adsorption-by-polysorbate-80
#6
Mio Tange, Akino Matsumoto, Miyako Yoshida, Honami Kojima, Tamami Haraguchi, Takahiro Uchida
The purpose of the study was to evaluate the adsorption of filgrastim on infusion sets (comprising infusion bag, line and filter) and to compare the adsorption of the original filgrastim preparation with biosimilar preparations using HPLC. The inhibitory effect of polysorbate 80 on this adsorption was also evaluated. Filgrastim was mixed with isotonic sodium chloride solution or 5% (w/v) glucose solution in the infusion fluid. Filgrastim adsorption on infusion sets was observed with all preparations and with both types of infusion solution...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28038376/lean-muscle-volume-of-the-thigh-has-a-stronger-relationship-with-muscle-power-than-muscle-strength-in-women-with-knee-osteoarthritis
#7
Michael J Davison, Monica R Maly, Peter J Keir, Sandani M Hapuhennedige, Amie T Kron, Jonathan D Adachi, Karen A Beattie
BACKGROUND: Thigh lean muscle and intramuscular fat have been implicated in the impairment of physical function observed in people with knee osteoarthritis. We investigated the relationships of quadriceps and hamstrings intramuscular fat fraction and lean muscle volume with muscle power and strength, controlling for neuromuscular activation, and physical performance in women with knee OA. METHODS: Women (n=20) 55years or older with symptomatic, radiographic knee osteoarthritis underwent a 3...
November 25, 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/28035792/novel-microfluidic-device-for-the-continuous-separation-of-cancer-cells-using-dielectrophoresis
#8
Anas Alazzam, Bobby Mathew, Falah Alhammadi
We describe the design, microfabrication, and testing of a microfluidic device for separation of cancer cells based on dielectrophoresis. Cancer cells, specifically Green fluorescent protein-labeled MDA-MB-231, are successfully separated from a heterogeneous mixture of the same and normal blood cells. MDA-MB-231 cancer cells are separated with an accuracy that enables precise detection and counting of circulating tumor cells present among normal blood cells. The separation is performed using a set of planar interdigitated transducer electrodes that are deposited on the surface of a glass wafer and slightly protrude into the separation microchannel at one side...
December 30, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/28033580/extracellular-cl-free-induced-cardioprotection-against-hypoxia-reoxygenation-is-associated-with-attenuation-of-mitochondrial-permeability-transition-pore
#9
Xian-Gui Zhang, Le Zhao, Yi Zhang, Yuan-Yuan Li, Huan Wang, Guang-Ling Duan, Lin Xiao, Xiao-Ran Li, He-Ping Chen
The isotonic substitution of extracellular chloride by gluconate (extracellular Cl(-)-free) has been demonstrated to elicit cardioprotection by attenuating ischaemia/reperfusion-induced elevation of intracellular chloride ion concentration ([Cl(-)]i). However, the downstream mechanism underlying the cardioprotective effect of extracellular Cl(-)-free is not fully established. Here, it was investigated whether extracellular Cl(-)-free attenuates mitochondrial dysfunction after hypoxia/reoxygenation (H/R) and whether mitochondrial permeability transition pore (mPTP) plays a key role in the extracellular Cl(-)-free cardioprotection...
December 26, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28028987/evaluation-of-the-erosive-potential-of-selected-isotonic-drinks-in-vitro-studies
#10
Aneta Ostrowska, Witold Szymański, Łukasz Kołodziejczyk, Elżbieta Bołtacz-Rzepkowska
BACKGROUND: Isotonic drinks are an important component of the diet of athletes. Sports drinks cause the body to maintain proper hydration and supplement minerals which are lost in sweat during excessive exercising. Aside from the benefits of isotonic drinks, it is important to be aware of the harmful effects of citric acid within the products, which could cause enamel erosion. OBJECTIVES: The aim of the study was to evaluate the erosive potential of sports drinks using confocal scanning laser microscopy (CLSM)...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28006941/early-changes-of-brain-perfusion-after-subarachnoid-hemorrhage-the-effect-of-sodium-nitroprusside
#11
M Kolar, K Nohejlova, J Mares, J Pachl
Causes of early hypoperfusion after subarachnoid hemorrhage (SAH) include intracranial hypertension as well as vasoconstriction. The aim of the study was to assess the effect of intracerebroventricular (ICV) administration of sodium nitroprusside (SNP) on early hypoperfusion after SAH. Male Wistar rats (220-240 g) were used, SAH group received 250 microl of fresh autologous arterial blood into the prechiasmatic cistern; sham-operated animals received 250 microl of isotonic solution. Therapeutic intervention: ICV administration of 10 microg SNP; 5 microl 5 % glucose (SNP vehicle) and untreated control...
December 22, 2016: Physiological Research
https://www.readbyqxmd.com/read/28002447/influence-of-polymorphisms-in-the-htr3a-and-htr3b-genes-on-experimental-pain-and-the-effect-of-the-5-ht3-antagonist-granisetron
#12
Sofia Louca Jounger, Nikolaos Christidis, Britt Hedenberg-Magnusson, Thomas List, Peter Svensson, Martin Schalling, Malin Ernberg
The aim of this study was to investigate experimentally if 5-HT3 single nucleotide polymorphisms (SNP) contribute to pain perception and efficacy of the 5-HT3-antagonist granisetron and sex differences. Sixty healthy participants were genotyped regarding HTR3A (rs1062613) and HTR3B (rs1176744). First, pain was induced by bilateral hypertonic saline injections (HS, 5.5%, 0.2 mL) into the masseter muscles. Thirty min later the masseter muscle on one side was pretreated with 0.5 mL granisetron (1 mg/mL) and on the other side with 0...
2016: PloS One
https://www.readbyqxmd.com/read/28001483/bayesian-isotonic-regression-dose-response-bird-model
#13
Wen Li, Haoda Fu
Understanding dose-response relationship is a crucial step in drug development. There are a few parametric methods to estimate dose-response curves, such as the Emax model and the logistic model. These parametric models are easy to interpret and, hence, widely used. However, these models often require the inclusion of patients on high-dose levels; otherwise, the model parameters cannot be reliably estimated. To have robust estimation, nonparametric models are used. However, these models are not able to estimate certain important clinical parameters, such as ED50 and Emax...
December 21, 2016: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/27999537/nonlinear-coupling-between-cortical-oscillations-and-muscle-activity-during-isotonic-wrist-flexion
#14
Yuan Yang, Teodoro Solis-Escalante, Mark van de Ruit, Frans C T van der Helm, Alfred C Schouten
Coupling between cortical oscillations and muscle activity facilitates neuronal communication during motor control. The linear part of this coupling, known as corticomuscular coherence, has received substantial attention, even though neuronal communication underlying motor control has been demonstrated to be highly nonlinear. A full assessment of corticomuscular coupling, including the nonlinear part, is essential to understand the neuronal communication within the sensorimotor system. In this study, we applied the recently developed n:m coherence method to assess nonlinear corticomuscular coupling during isotonic wrist flexion...
2016: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/27996280/a-comparative-pilot-study-of-the-efficacy-and-safety-of-nebulized-magnesium-sulfate-and-intravenous-magnesium-sulfate-in-children-with-severe-acute-asthma
#15
Tassalapa Daengsuwan, Sureerat Watanatham
INTRODUCTION: Severe asthmatic attacks are life-threatening requiring serious medical attention. Intravenous MgSO4 is an efficient medication proven to improve outcomes. Recently, many research has supported the administration of nebulized MgSO4 in adults with critical asthma. However, its benefits for treating childhood asthma have been little investigated. This study compared the clinical efficacy and the adverse effect of nebulized MgSO4 and intravenous MgSO4 in the treatment of children with severe acute asthma...
December 12, 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/27989926/age-differences-in-dynamic-fatigability-and-variability-of-arm-and-leg-muscles-associations-with-physical-function
#16
Jonathon Senefeld, Tejin Yoon, Sandra K Hunter
INTRODUCTION: It is not known whether the age-related increase in fatigability of fast dynamic contractions in lower limb muscles also occurs in upper limb muscles. We compared age-related fatigability and variability of maximal-effort repeated dynamic contractions in the knee extensor and elbow flexor muscles; and determined associations between fatigability, variability of velocity between contractions and functional performance. METHODS: 35 young (16 males; 21...
October 27, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27989829/osmolality-of-antisense-oligonucleotide-parenteral-formulations-implications-on-counterion-dissociation-and-recommended-osmometry-techniques
#17
Marc Lim, Andrew Dibble
The intrinsic osmolality of aqueous solutions of sodium salt antisense oligonucleotides (ASOs) has been studied to inform formulation practices, understand the molecular basis underlying the difference between theoretical and empirical results, and determine suitable measurement methods. It was found that regardless of nucleotide sequence, ASO concentration of ∼140mg/mL has isotonic osmolality of ∼290mOsm/kg water (SI unit: mmol osmotically-active particles/kg water), such that lower concentration formulations require excipients for tonicity adjustment...
October 27, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27988910/importance-of-contraction-history-on-muscle-force-of-porcine-urinary-bladder-smooth-muscle
#18
Robin Menzel, Markus Böl, Tobias Siebert
INTRODUCTION: The purpose of this study was to provide a comprehensive dataset of porcine urinary bladder smooth muscle properties. Particularly, the history dependence of force production, namely force depression (FD) following shortening and force enhancement (FE) following stretch, was analysed. During active micturition, the circumference of the urinary bladder changes enormously. Thus, FD might be an important phenomenon during smooth muscle contraction. MATERIALS AND METHODS: Electrically stimulated, intact urinary bladder strips from pigs (n = 10) were suspended in an aerated-filled organ bath, and different isometric, isotonic, and isokinetic contraction protocols were performed to determine the force-length and the force-velocity relation...
December 17, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27984434/effects-of-surface-treatment-modification-and-implant-design-in-implants-placed-crestal-and-subcrestally-applying-delayed-loading-protocol
#19
José Eduardo Maté Sánchez de Val, Gerardo Gómez-Moreno, Matilde Ruiz-Linares, Juan Carlos Prados Frutos, Sergio Alexandre Gehrke, José Luis Calvo-Guirado
OBJECTIVES: The aim of this study is to evaluate the effect of the surface modification and cervical implant design on the bone remodeling in implants installed at the crestal and subcrestal bone level. METHODS: Ten American Fox Hound of approximately 1 year of age, each weighing approximately 14 to 15 kg, were used for this study. Two different dental implant macrodesign were used: cylindric-conical with 3.5 mm of diameter and 9 in length (implant A) and conical with 2...
December 14, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27982264/influence-of-chlorpromazine-on-renal-histology-of-rats-submitted-to-ischemia-and-reperfusion-injury
#20
Júlio César Foiatto, Nicolau Gregori Czeczko, Eduardo Gabriel Guerber Wietzikoski, Osvaldo Malafaia, Thadeu Brenny, André Matos de Oliveira, Regina de Paula Xavier Gomes
PURPOSE: To analyze the influence of chlorpromazine on renal histology of rats submitted to ischemia and reperfusion injury. METHODS: Sixteen Wistar rats - split in two groups - have been used: control group, receiving 3 mg/kg isotonic saline solution through caudal vein, and, the chlorpromazine group, receiving 3 mg/kg-IV of such medication. The nephrectomy of the left kidney lower third was carried out; immediately, the test-drug was administrated. After 15 minutes of test-drug administration, the renal pedicle was clamped; in 60 minutes of ischemia it was released...
November 2016: Acta Cirúrgica Brasileira
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