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https://www.readbyqxmd.com/read/28748991/-analysis-of-incident-reports-in-an-anesthesiology-unit-of-a-university-hospital
#1
Luis Marfán, Juan C Pedemonte, Daniela Sandoval, Constanza Ferdinand, Lorena Camus, Héctor J Lacassie
BACKGROUND: Incident reporting is an effective strategy used to enhance patient safety. An incident is an event that could eventually result in harm to a patient. AIM: To classify and analyze incidents reported by an Anesthesiology division at a University hospital in Chile. MATERIAL AND METHODS: A retrospective analysis of the reported incidents registered in our institutional database from January 2008 to January 2014. They were classified according to three variables proposed by the World Health Organization system to determine the type of incident and patients’ potential harm...
April 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28748957/management-of-cardiovascular-diseases-in-patients-with-obesity
#2
REVIEW
Carl J Lavie, Ross Arena, Martin A Alpert, Richard V Milani, Hector O Ventura
The management of cardiovascular diseases (CVD) in patients with obesity presents numerous challenges. Obesity has a negative effect on almost all of the major CVD risk factors, and adversely influences cardiovascular structure and function. Patients who are overweight or obese have a higher incidence of almost all CVDs compared with patients who are of normal weight. However, those who are overweight or obese seem to have a better short-term and medium-term prognosis after major CVD events and interventional procedures or cardiac surgeries than leaner patients, a phenomenon termed the 'obesity paradox'...
July 27, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28748770/management-of-diabetic-surgical-patients-in-a-deployed-field-hospital-a-model-for-acute-non-communicable-disease-care-in-disaster
#3
Kathleen M McDermott, Ruth M Hardstaff, Sophie Alpen, David J Read, Nicholas R Coatsworth
Sudden onset disasters (SODs) have affected over 1.5 billion of the world's population in the past decade. During the same time, developing nations have faced a sustained increase in the burden of non-communicable disease (NCD) with extra pressure placed on health systems. The combined increase in SODs and the NCD epidemic facing the world's most disaster-prone nations will present new challenges to emergency medical teams (EMTs) during disaster response. This report details the experience as an EMT during the Typhoon Haiyan disaster of 2013, with particular reference to the challenges of diabetic management in a surgical field hospital...
July 27, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28748652/bleeding-related-hospital-admissions-and-30-day-re-admissions-in-patients-with-nonvalvular-atrial-fibrillation-treated-with-dabigatran-versus-warfarin
#4
Wallis C Y Lau, Xue Li, Ian C K Wong, Kenneth K C Man, Gregory Y H Lip, Wai K Leung, Chung W Siu, Esther W Chan
BACKGROUND: Reducing 30-day hospital re-admission is a policy priority worldwide. Warfarin-related bleeding is among the most common cause of hospital admissions due to adverse drug events. Compared to warfarin, dabigatran achieve full anticoagulation effect more quickly following its initiation, hence may lead to early-onset bleeds. OBJECTIVES: To compare the incidence of bleeding-related hospital admissions and 30-day re-admissions with dabigatran versus warfarin in patients with nonvalvular atrial fibrillation (NVAF)...
July 27, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28748523/management-and-prevention-of-saphenous-vein-graft-failure-a-review
#5
REVIEW
Peter McKavanagh, Bobby Yanagawa, George Zawadowski, Asim Cheema
Coronary artery bypass grafting (CABG) remains a vital treatment for patients with multivessel coronary artery disease (CAD), especially diabetics. The long-term benefit of the internal thoracic artery graft is well established and remains the gold standard for revascularization of severe CAD. It is not always possible to achieve complete revascularization through arterial grafts, necessitating the use of saphenous vein grafts (SVG). Unfortunately, SVGs do not have the same longevity, and their failure is associated with significant adverse cardiac outcomes and mortality...
July 26, 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28748252/-mn1606sp-by-spencer-filial-soybean-population-reveals-novel-quantitative-trait-loci-and-interactions-among-loci-conditioning-sds-resistance
#6
Alexander S Luckew, Sivakumar Swaminathan, Leonor F Leandro, James H Orf, Silvia R Cianzio
Four novel QTL and interactions among QTL were identified in this research, using as a parent line the most SDS-resistant genotype within soybean cultivars of the US early maturity groups. Soybean sudden death syndrome (SDS) reduces soybean yield in most of the growing areas of the world. The causal agent of SDS, soilborne fungus Fusarium virguliforme (Fv), releases phytotoxins taken up by the plant to produce chlorosis and necrosis in the leaves. Planting resistant cultivars is the most successful management practice to control the disease...
July 26, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28747604/methotrexate-associated-lymphoproliferative-disorder
#7
Yuko Kaneko
  Methotrexate-associated lymphproliferative disorder (MTX-LPD) is a rare but critical complication developing in patients treated with methotrexate. Now that methotrexate is an anchor drug in the management of rheumatoid arthritis and become commonly used, MTX-LPD cases have increased. Many things has been unclear such as incidence, demographic characters, and risk factors. However, as the researches increased, several interesting topics has been demonstrated like associations with Epsteiin-Barr virus and with cell-mediated immunity...
2017: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28747535/palliative-care-in-end-stage-valvular-heart-disease
#8
REVIEW
Jill M Steiner, Stephanie Cooper, James N Kirkpatrick
Valvular heart disease (VHD), particularly aortic valve disease, is prevalent with increasing incidence. When surgery is not possible, or when risks outweigh benefits, percutaneous treatment options may offer effective alternatives. However, procedures may not always go as planned, and frail patients or those whose symptoms are caused by other comorbidities may not benefit from valve intervention at all. Significant effort should be made to assess frailty, comorbidities and patient goals prior to intervention...
August 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28747374/babesia-microti-from-mice-to-ticks-to-an-increasing-number-of-highly-susceptible-humans
#9
Lars F Westblade, Matthew S Simon, Blaine A Mathison, Laura A Kirkman
Babesia microti, a zoonotic intraerythrocytic parasite, is the primary etiological agent of human babesiosis in the United States (US). Human infection ranges from subclinical illness to severe disease resulting in death, with symptoms related to host immune status. Despite advances in our understanding and management of B. microti, incidence of infection has increased in the US. Therefore, research focused on eradicating disease and optimizing clinical management is essential. Herein, we review this remarkable organism with emphasis on the clinical, diagnostic, and therapeutic aspects of human disease...
July 26, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28747191/implementation-findings-from-a-hybrid-iii-implementation-effectiveness-trial-of-the-diabetes-prevention-program-dpp-in-the-veterans-health-administration-vha
#10
Laura J Damschroder, Caitlin M Reardon, Mona AuYoung, Tannaz Moin, Santanu K Datta, Jordan B Sparks, Matthew L Maciejewski, Nanette I Steinle, Jane E Weinreb, Maria Hughes, Lillian F Pinault, Xinran M Xiang, Charles Billington, Caroline R Richardson
BACKGROUND: The Diabetes Prevention Program (DPP) is an effective lifestyle intervention to reduce incidence of type 2 diabetes. However, there are gaps in knowledge about how to implement DPP. The aim of this study was to evaluate implementation of DPP via assessment of a clinical demonstration in the Veterans Health Administration (VHA). METHODS: A 12-month pragmatic clinical trial compared weight outcomes between the Veterans Affairs Diabetes Prevention Program (VA-DPP) and the usual care MOVE!® weight management program (MOVE!)...
July 26, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28747169/optimising-decision-making-on-illness-absenteeism-due-to-fever-and-common-infections-within-childcare-centres-development-of-a-multicomponent-intervention-and-study-protocol-of-a-cluster-randomised-controlled-trial
#11
K K B Peetoom, R Crutzen, J M H A Bohnen, R Verhoeven, H J M G Nelissen-Vrancken, B Winkens, G J Dinant, J W L Cals
BACKGROUND: Evidence has shown that children 0-4 year-old attending childcare are prone to acquire infections compared to children cared for at home, with fever being the most common symptom. Illness absenteeism due to fever and common infections is substantial and mostly driven by unrealistic concerns and negative attitude towards fever of both childcare staff and parents, resulting in illness absenteeism from childcare, work absenteeism among parents and healthcare service use. The objective of this study is to optimise decision making among childcare staff on illness absenteeism due to fever and common infections in childcare...
July 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28747052/diagnostic-and-therapeutic-features-of-small-bowel-involvement-in-portal-hypertension
#12
Juan Egea Valenzuela, Tania Fernández Llamas, Ana Victoria García Marín, Fernando Alberca de Las Parras, Fernando Carballo Álvarez
Enteropathy is a lesser known complication of portal hypertension and consists of different changes in the mucosal layer of the small bowel which lead to the appearance of vascular and inflammatory lesions. It can be an important co-factor in the development of anemia in the cirrhotic population, and nowadays an easy and non-invasive diagnosis can be made thanks to capsule endoscopy. However, it is rarely considered in the management of patients with portal hypertension. Some aspects such as pathogenesis or incidence remain unclear and no specific recommendations are included in the guidelines regarding diagnosis or treatment...
July 27, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28746590/successful-treatment-of-post-transplant-relapsed-acute-myeloid-leukemia-with-flt3-internal-tandem-duplication-using-the-combination-of-induction-chemotherapy-donor-lymphocyte-infusion-sorafenib-and-azacitidine-report-of-three-cases
#13
Paulo Vidal Campregher, Vinicius Renan Pinto de Mattos, Marco Aurélio Salvino, Fabio Pires de Souza Santos, Nelson Hamerschlak
Acute myeloid leukemia is a hematopoietic stem cell neoplastic disease associated with high morbidity and mortality. The presence of FLT3 internal tandem duplication mutations leads to high rates of relapse and decreased overall survival. Patients with FLT3 internal tandem duplication are normally treated with hematopoietic stem cell transplantation in first complete remission. Nevertheless, the incidence of post-transplant relapse is considerable in this group of patients, and the management of this clinical condition is challenging...
July 24, 2017: Einstein
https://www.readbyqxmd.com/read/28746570/brazilian-guidelines-for-the-clinical-management-of-paracoccidioidomycosis
#14
Maria Aparecida Shikanai-Yasuda, Rinaldo Pôncio Mendes, Arnaldo Lopes Colombo, Flávio de Queiroz-Telles, Adriana Satie Gonçalves Kono, Ana Maria Paniago, André Nathan, Antonio Carlos Francisconi do Valle, Eduardo Bagagli, Gil Benard, Marcelo Simão Ferreira, Marcus de Melo Teixeira, Mario León Silva-Vergara, Ricardo Mendes Pereira, Ricardo de Souza Cavalcante, Rosane Hahn, Rui Rafael Durlacher, Zarifa Khoury, Zoilo Pires de Camargo, Maria Luiza Moretti, Roberto Martinez
Paracoccidioidomycosis is a systemic fungal disease occurring in Latin America that is associated with rural environments and agricultural activities. However, the incidence and prevalence of paracoccidiodomycosis is underestimated because of the lack of compulsory notification. If paracoccidiodomycosis is not diagnosed and treated early and adequately, the endemic fungal infection could result in serious sequelae. While the Paracoccidioides brasiliensis ( P. brasiliensis ) complex has been known to be the causal agent of paracoccidiodomycosis, a new species, Paracoccidioides lutzii ( P...
July 20, 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28746354/spatio-temporal-epidemiology-of-japanese-encephalitis-in-nepal-2007-2015
#15
Dhan Kumar Pant, Tenzin Tenzin, Rakesh Chand, Barun Kumar Sharma, Padam Raj Bist
Japanese encephalitis (JE) is a major public health problem in Nepal. For the effective management and surveillance of JE, a clear understanding of its epidemiology is essential. Therefore, we conducted descriptive and spatial analyses to understand the spatio-temporal distribution of JE in human in Nepal. From 2007 to 2015, 1,823 JE cases were reported with a cumulative mean incidence of 0.735/100,000 population and a case fatality rate of 6.6%. The death rate in the up-to-24 years of age group was 74%. The JE cases were most commonly reported in the age group of 1-14 years...
2017: PloS One
https://www.readbyqxmd.com/read/28745846/acute-decompensated-heart-failure-new-strategies-for-improving-outcomes-digest
#16
Emily Singer Fisher, Boyd Burns, Jeremy Kim
Acute decompensated heart failure is a common emergency department presentation with significant associated morbidity and mortality. Heart failure accounts for more than 1 million hospitalizations annually, with a steadily increasing incidence as our population ages. This issue reviews recent literature regarding appropriate management of emergency department presentations of acute decompensated heart failure, with special attention to newer medication options. Emergency department management and appropriate interventions are discussed, along with critical decision-making points in resuscitation for both hypertensive and hypotensive patients...
May 22, 2017: Emergency Medicine Practice
https://www.readbyqxmd.com/read/28745793/hypoxia-associated-biomarkers-in-lung-cancer-an-update
#17
W Cui, F Wu, L Ma
The high incidence rates of lung cancer have resulted in multiple progressions in cancer research leading to the development of novel therapeutic strategies. The three main branches of cancer research where improvements are being made are surgery, chemotherapy, and radiotherapy. These research developments have significantly improved the survival rates of cancer patients as most of these therapeutic options target specific molecules involved in cancer progression and metastasis. Experimental research has successfully identified potentially important molecules responsible for cancer progression...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28745791/the-correlation-between-cognitive-impairment-and-ambulatory-blood-pressure-in-patients-with-cerebral-small-vessel-disease
#18
X-F Li, L-M Cui, D-K Sun, H-T Wang, W-G Liu
OBJECTIVE: The present study was aimed to analyze the correlation between cognitive impairment and ambulatory blood pressure in patients with cerebral small vessel disease (CSVD). PATIENTS AND METHODS: 108 patients with CSVD received in our hospital were selected. Assessment of cognitive impairment was by the Montreal Cognitive Assessment (MoCA). 39 cases were established as the impairment group and 69 cases were established as the normal group. 24 h ambulatory blood pressure was monitored, and changes in ambulatory blood pressure parameters between the two groups were compared...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28743786/outcomes-of-patients-presenting-with-clinical-indices-of-spontaneous-reperfusion-in-st-elevation-acute-coronary-syndrome-undergoing-deferred-angiography
#19
Paul Fefer, Roy Beigel, Shaul Atar, Doron Aronson, Arthur Pollak, Doron Zahger, Elad Asher, Zaza Iakobishvili, Nir Shlomo, Ronny Alcalai, Michal Einhorn-Cohen, Amit Segev, Ilan Goldenberg, Shlomi Matetzky
BACKGROUND: Few data are available regarding the optimal management of ST-elevation myocardial infarction patients with clinically defined spontaneous reperfusion (SR). We report on the characteristics and outcomes of patients with SR in the primary percutaneous coronary intervention era, and assess whether immediate reperfusion can be deferred. METHODS AND RESULTS: Data were drawn from a prospective nationwide survey, ACSIS (Acute Coronary Syndrome Israeli Survey)...
July 25, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28743780/supply-chain-optimization-at-an-academic-medical-center
#20
Jonathan Labuhn, Philip Almeter, Christopher McLaughlin, Philip Fields, Benjamin Turner
PURPOSE: A successful supply chain optimization project that leveraged technology, engineering principles, and a technician workflow redesign in the setting of a growing health system is described. SUMMARY: With continued rises in medication costs, medication inventory management is increasingly important. Proper management of central pharmacy inventory and floor-stock inventory in automated dispensing cabinets (ADCs) can be challenging. In an effort to improve control of inventory costs in the central pharmacy of a large academic medical center, the pharmacy department implemented a supply chain optimization project in collaboration with the medical center's inhouse team of experts on process improvement and industrial engineering...
August 1, 2017: American Journal of Health-system Pharmacy: AJHP
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