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Jeffrey T Howard, Zsolt T Stockinger, Andrew P Cap, Jeffrey A Bailey, Kirby R Gross
BACKGROUND: Tranexamic acid (TXA) has been previously reported to have a mortality benefit in civilian and combat-related trauma, and was thus added to the Joint Theater Trauma System Damage Control Resuscitation Clinical Practice Guideline. As part of ongoing system-wide performance improvement, the use of TXA has been closely monitored. The goal was to evaluate the efficacy and safety of TXA use in military casualties and provide additional guidance for continued use. METHODS: A total of 3,773 casualties were included in this retrospective, observational study of data gathered from a trauma registry...
June 9, 2017: Journal of Trauma and Acute Care Surgery
John Kepros
QUESTION: Does a prognostic model accurately estimate risk for early death in patients with traumatic bleeding? METHODS: HASH(0x34e4de8) DESIGN: 2 cohort studies: Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage (CRASH-2) trial (derivation) and Trauma Audit and Research Network (TARN) dataset (validation). SETTING: 274 hospitals in 40 countries (derivation cohort) and 60% of hospitals that received trauma patients in England and Wales and some hospitals in Europe (validation cohort)...
November 20, 2012: Annals of Internal Medicine
Pablo Perel, David Prieto-Merino, Haleema Shakur, Tim Clayton, Fiona Lecky, Omar Bouamra, Rob Russell, Mark Faulkner, Ewout W Steyerberg, Ian Roberts
OBJECTIVE: To develop and validate a prognostic model for early death in patients with traumatic bleeding. DESIGN: Multivariable logistic regression of a large international cohort of trauma patients. SETTING: 274 hospitals in 40 high, medium, and low income countries PARTICIPANTS: Prognostic model development: 20,127 trauma patients with, or at risk of, significant bleeding, within 8 hours of injury in the Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage (CRASH-2) trial...
August 15, 2012: BMJ: British Medical Journal
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