keyword
MENU ▼
Read by QxMD icon Read
search

Sudden infant death

keyword
https://www.readbyqxmd.com/read/29331839/functional-characterization-of-a-novel-herg-variant-in-a-family-with-recurrent-sudden-infant-death-syndrome-retracting-a-genetic-diagnosis
#1
Valentine Sergeev, Frances Perry, Thomas M Roston, Shubhayan Sanatani, Glen F Tibbits, Thomas W Claydon
Long QT syndrome (LQTS) is the most common cardiac ion channelopathy and has been found to be responsible for approximately 10% of sudden infant death syndrome (SIDS) cases. Despite increasing use of broad panels and now whole exome sequencing (WES) in the investigation of SIDS, the probability of identifying a pathogenic mutation in a SIDS victim is low. We report a family-based study who are afflicted by recurrent SIDS in which several members harbor a variant, p.Pro963Thr, in the C-terminal region of the human-ether-a-go-go (hERG) gene, published to be responsible for cases of LQTS type 2...
December 20, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29329929/detoxification-genes-polymorphisms-in-sids-exposed-to-tobacco-smoke
#2
Laura Filonzi, Cinzia Magnani, Anna Maria Lavezzi, Marina Vaghi, Luana Nosetti, Francesco Nonnis Marzano
The best hypothesis to explain Sudden Infant Death Syndrome (SIDS) pathogenesis is offered by the "triple risk model", which suggests that an interaction of different variables related to exogenous stressors and infant vulnerability may lead to the syndrome. Environmental factors are triggers that act during a particular sensible period, modulated by intrinsic genetic characteristics. Although literature data show that one of the major SIDS risk factors is smoking exposure, a specific involvement of molecular components has never been highlighted...
January 9, 2018: Gene
https://www.readbyqxmd.com/read/29324729/vital-signs-trends-and-disparities-in-infant-safe-sleep-practices-united-states-2009-2015
#3
Jennifer M Bombard, Katherine Kortsmit, Lee Warner, Carrie K Shapiro-Mendoza, Shanna Cox, Charlan D Kroelinger, Sharyn E Parks, Deborah L Dee, Denise V D'Angelo, Ruben A Smith, Kim Burley, Brian Morrow, Christine K Olson, Holly B Shulman, Leslie Harrison, Carri Cottengim, Wanda D Barfield
There have been dramatic improvements in reducing infant sleep-related deaths since the 1990s, when recommendations were introduced to place infants on their backs for sleep. However, there are still approximately 3,500 sleep-related deaths among infants each year in the United States, including those from sudden infant death syndrome, accidental suffocation and strangulation in bed, and unknown causes. Unsafe sleep practices, including placing infants in a nonsupine (on side or on stomach) sleep position, bed sharing, and using soft bedding in the sleep environment (e...
January 12, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29299793/bed-sharing-in-the-first-8-weeks-of-life-an-australian-study
#4
H M Cunningham, H Vally, L Bugeja
Background As the evidence continues to emerge about the relationship between sudden unexpected death in infancy (SUDI) and the way an infant sleeps, providing consistent and evidence-informed recommendations on how best to sleep infants is an ongoing challenge. A recent case series study in the state of Victoria, Australia, identified 45.8% of sleep-related infant deaths occurred whilst bed-sharing. This study prompted the need for further exploration of infant sleeping practices, including bed-sharing, in this population...
January 3, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29299712/cardiovascular-autonomic-dysfunction-in-sudden-infant-death-syndrome
#5
REVIEW
Rosemary S C Horne
A failure of cardiorespiratory control mechanisms, together with an impaired arousal response from sleep, are believed to play an important role in the final event of sudden infant death syndrome (SIDS). The 'triple risk model' describes SIDS as an event that results from the intersection of three overlapping factors: (1) a vulnerable infant, (2) a critical developmental period in homeostatic control and (3) an exogenous stressor. In an attempt to understand how the triple risk hypothesis is related to infant cardiorespiratory physiology, many researchers have examined how the known risk and protective factors for SIDS alter infant cardiovascular control during sleep...
January 3, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29289380/sudden-infant-death-syndrome-attention-deficit-hyperactivity-disorder-and-vaccines-longitudinal-population-analyses
#6
Y Tony Yang, Jana Shaw
Concerns about a potential link between sudden infant death syndrome (SIDS), attention deficit and hyperactivity disorder (ADHD) and vaccination are unsupported by longitudinal evidence. The analyses employed a multivariate mixed-effects model analyzing data from the National Immunization Survey, School Vaccination Assessment Reports, National Vital Statistics and National Children's Health Survey. We found that state-level childhood vaccine uptake for age appropriate vaccines was neither associated with the decline in the incidence of SIDS nor rise in the prevalence of ADHD...
December 27, 2017: Vaccine
https://www.readbyqxmd.com/read/29249897/is-it-time-for-a-sudden-infant-death-syndrome-sids-awareness-campaign-community-stakeholders-perceptions-of-sids
#7
Audra Gollenberg, Kim Fendley
Background: Sudden infant death syndrome (SIDS) remains a leading cause of infant death in the United States and in Virginia, the SIDS rate is higher than the national average. We sought to gauge the perceptions among community-identified stakeholders as to community resource needs to reduce SIDS. Methods: We used snowball sampling to identify important community stakeholders to be interviewed as key informants. A semi-structured interview lasting 45 min-2 hours was delivered to determine resource needs to reduce SIDS, and whether high-risk community members were aware of SIDS risk factors among stakeholders representing a variety of disciplines...
2018: Child care in practice: Northern Ireland journal of multi-disciplinary child care practice
https://www.readbyqxmd.com/read/29247119/applying-high-resolution-variant-classification-to-cardiac-arrhythmogenic-gene-testing-in-a-demographically-diverse-cohort-of-sudden-unexplained-deaths
#8
Ying Lin, Nori Williams, Dawei Wang, William Coetzee, Bo Zhou, Lucy S Eng, Sung Yon Um, Ruijun Bao, Orrin Devinsky, Thomas V McDonald, Barbara A Sampson, Yingying Tang
BACKGROUND: Genetic variant interpretation contributes to testing yield differences reported for sudden unexplained death. Adapting a high-resolution variant interpretation framework, which considers disease prevalence, reduced penetrance, genetic heterogeneity, and allelic contribution to determine the maximum tolerated allele count in gnomAD, we report an evaluation of cardiac channelopathy and cardiomyopathy genes in a large, demographically diverse sudden unexplained death cohort that underwent thorough investigation in the United States' largest medical examiner's office...
December 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29243157/why-is-a-prone-sleeping-position-dangerous-for-certain-infants
#9
Roger W Byard, Fiona Bright, Robert Vink
The prone (face down) sleeping position is known to be associated with a significantly increased risk of sudden and unexpected death in infancy (sudden infant death syndrome or SIDS), however, the reasons for this are unclear. Suggested mechanisms have involved suffocation from occlusion of the external airways by soft bedding/pillows or from flattening of the nose with backward displacement of the tongue, rebreathing of carbon dioxide, blunting of arousal responses with decreased cardiac responses to auditory stimulation, diaphragmatic splinting or fatigue, lowering of vasomotor tone with tachycardia, nasopharyngeal bacterial overgrowth, overheating, alteration of sleep patterns, compromise of cerebral blood flow and upper airway obstruction from distortion of nasal cartilages...
December 14, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29241711/l-carnitine-and-heart-disease
#10
REVIEW
Zhong-Yu Wang, Ying-Yi Liu, Guo-Hui Liu, Hai-Bin Lu, Cui-Ying Mao
Cardiovascular disease (CVD) is a key cause of deaths worldwide, comprising 15-17% of healthcare expenditure in developed countries. Current records estimate an annual global average of 30 million cardiac dysfunction cases, with a predicted escalation by two-three folds for the next 20-30years. Although β-blockers and angiotensin-converting-enzymes are commonly prescribed to control CVD risk, hepatotoxicity and hematological changes are frequent adverse events associated with these drugs. Search for alternatives identified endogenous cofactor l-carnitine, which is capable of promoting mitochondrial β-oxidation towards a balanced cardiac energy metabolism...
December 11, 2017: Life Sciences
https://www.readbyqxmd.com/read/29241647/safety-of-currently-licensed-hepatitis-b-surface-antigen-vaccines-in-the-united-states-vaccine-adverse-event-reporting-system-vaers-2005-2015
#11
Penina Haber, Pedro L Moro, Carmen Ng, Paige W Lewis, Beth Hibbs, Sarah F Schillie, Noele P Nelson, Rongxia Li, Brock Stewart, Maria V Cano
INTRODUCTION: Currently four recombinant hepatitis B (HepB) vaccines are in use in the United States. HepB vaccines are recommended for infants, children and adults. We assessed adverse events (AEs) following HepB vaccines reported to the Vaccine Adverse Event Reporting System (VAERS), a national spontaneous reporting system. METHODS: We searched VAERS for reports of AEs following single antigen HepB vaccine and HepB-containing vaccines (either given alone or with other vaccines), from January 2005 - December 2015...
December 11, 2017: Vaccine
https://www.readbyqxmd.com/read/29235984/deaths-leading-causes-for-2015
#12
Melonie Heron
Objectives-This report presents final 2015 data on the 10 leading causes of death in the United States by age, sex, race, and Hispanic origin. Leading causes of infant, neonatal, and postneonatal death are also presented. This report supplements "Deaths: Final Data for 2015," the National Center for Health Statistics' annual report of final mortality statistics. Methods-Data in this report are based on information from all death certificates filed in the 50 states and the District of Columbia in 2015. Causes of death classified by the International Classification of Diseases, Tenth Revision (ICD-10) are ranked according to the number of deaths assigned to rankable causes...
November 2017: National Vital Statistics Reports
https://www.readbyqxmd.com/read/29232618/pediatric-medicolegal-autopsy-in-france-a-forensic-histopathological-approach
#13
Clémence Delteil, Lucile Tuchtan, Julia Torrents, Caroline Capuani, Marie-Dominique Piercecchi-Marti
The aim of postmortem medicolegal examination in pediatric death is primarily to establish the circumstances and causes of death and to exclude child abuse. In France, pediatric death is systematically documented by medicolegal or medical autopsy. In case of medicolegal autopsy, the complementary examinations, requested and financed by justice, are rarely limited to a histopathological examination. However in medical autopsies other tools are available to the pathologist as toxicology, biochemistry and molecular biology...
January 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29221913/facial-asymmetry-correction-with-moulded-helmet-therapy-in-infants-with-deformational-skull-base-plagiocephaly
#14
Matthias Kreutz, Brigitte Fitze, Christoph Blecher, Augello Marcello, Ruben Simon, Rebecca Cremer, Hans-Florian Zeilhofer, Christoph Kunz, Johannes Mayr
PURPOSE: The recommendation issued by the American Academy of Pediatrics in the early 1990s to position infants on their back during sleep to prevent sudden infant death syndrome (SIDS) has dramatically reduced the number of deaths due to SIDS but has also markedly increased the prevalence of positional skull deformation in infants. Deformation of the base of the skull occurs predominantly in very severe deformational plagiocephaly and is accompanied by facial asymmetry, as well as an altered ear position, called ear shift...
October 16, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29208338/risky-behaviors-of-mothers-with-infants-on-sudden-infant-death-syndrome-in-turkey
#15
Çiğdem Erdoğan, Türkan Turan
PURPOSE: Sudden infant death syndrome is the most common cause of death during the post-neonatal period. Factors such as sleeping position, bed sharing, pillow use, smoking during pregnancy and the breastfeeding period constitute risk factors for sudden infant death syndrome. This study aims to identify the risky behaviors of mothers with infants that may put their children at risk for sudden infant death syndrome. DESIGN AND METHODS: This is a cross-sectional, descriptive study...
December 2, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29206359/parent-infant-co-sleeping-and-the-implications-for-sudden-infant-death-syndrome
#16
Joanne Straw, Pat Jones
In 2015 the National Institute for Health and Care Excellence (NICE) updated its 2006 guideline to clarify the association between parent infant co-sleeping and sudden infant death syndrome (SIDS). The practice of co-sleeping is a topic of continuing controversy and debate. Rather than highlighting the risks, the emphasis of the NICE guideline is to provide parents with balanced information so that they can make informed decisions about where their babies sleep. This contradicts previous public health messages on co-sleeping that discourages parents from the practice...
December 5, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/29192693/who-tells-a-mother-her-baby-has-died-communication-and-staff-presence-during-stillbirth-delivery-and-early-infant-death
#17
K J Gold, M C Treadwell, M E Mieras, N T Laventhal
OBJECTIVE: Perinatal loss (stillbirth or early infant death) is often a sudden, unexpected event for families. We evaluated who communicates the loss to the parents and who is there for support at the delivery or death. STUDY DESIGN: We conducted a mail survey of 900 bereaved and 500 live-birth mothers to assess emotional, physical and reproductive health outcomes. RESULTS: We had a 44% response rate at 9 months after birth or loss from 377 bereaved mothers and 232 with surviving infants...
December 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29189142/interpretation-of-cannabis-findings-in-the-hair-of-very-young-children-mission-impossible
#18
Pascal Kintz, Alice Ameline, Aude Eibel, Annie Geraut, Audrey Farrugia, Laurent Berthelon, Jean-Sebastien Raul
BACKGROUND: Hair has been suggested since the middle of the 90's to be a suitable matrix to document repetitive exposure to cannabis. Because it is possible to detect ∆9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD) in cannabis smoke, the identification of the metabolite, 11-nor-∆9-tetrahydrocannabinol carboxylic acid (THC-COOH) has been considered to allow the discrimination of active use. OBJECTIVE: Whereas the detection of drugs in a child's hair unambiguously shows drug handling in the environment of the child, it is difficult to distinguish between systemic incorporation into hair after ingestion or inhalation and external deposition into hair from smoke, dust, or contaminated surfaces...
November 29, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29184885/sudden-infant-death-syndrome-infection-prone-sleep-position-and-vagal-neuroimmunology
#19
Paul Nathan Goldwater
Recent findings suggest that infection (and sepsis) stand alone as the only plausible mechanism of causation of sudden infant death syndrome (SIDS) and accordingly achieves congruence with all clinicopathological and epidemiological findings. This review examines the role of infection in the pathogenesis of SIDS in the context of the major risk factor of prone sleep position. The study explores how sleep position could interact with the immune system and inflammatory response via vagal neural connections, which could play key roles in gut and immune homeostasis...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29181379/molecular-autopsy-for-sudden-death-in-the-young-is-data-aggregation-the-key
#20
Manuel Rueda, Jennifer L Wagner, Tierney C Phillips, Sarah E Topol, Evan D Muse, Jonathan R Lucas, Glenn N Wagner, Eric J Topol, Ali Torkamani
The Scripps molecular autopsy study seeks to incorporate genetic testing into the postmortem examination of cases of sudden death in the young (<45 years old). Here, we describe the results from the first 2 years of the study, which consisted of whole exome sequencing (WES) of a cohort of 50 cases predominantly from San Diego County. Apart from the individual description of cases, we analyzed the data at the cohort-level, which brought new perspectives on the genetic causes of sudden death. We investigated the advantages and disadvantages of using WES compared to a gene panel for cardiac disease (usually the first genetic test used by medical examiners)...
2017: Frontiers in Cardiovascular Medicine
keyword
keyword
53576
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"