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https://www.readbyqxmd.com/read/28811807/impact-of-24-hour-helpline-service-for-people-with-diabetes
#1
Farrukh Ahmed, Asim-Bin-Zafar, Musarrat Riaz, Erum Ghafoor, Rabia Abdul Rehman, Qutub Uddin
OBJECTIVE: To evaluate the impact and effectiveness of 24-hour helpline service in providing information and educating patients about self-management of diabetes. METHOD: The study was conducted at Baqai Institute of Diabetology & Endocrinology (BIDE), a tertiary diabetes care center, Karachi, Pakistan. People with diabetes attending the outpatient department from November 2012 to October 2014 were included in this study. After providing diabetes education, a helpline number was provided for emergency situations...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28803422/salidroside-improved-cerebrovascular-vasodilation-in-streptozotocin-induced-diabetic-rats-through-restoring-the-function-of-bkca-channel-in-smooth-muscle-cells
#2
Yu-Guang Ma, Jun-Wei Wang, Yin-Bin Zhang, Bao-Feng Wang, Zhi-Jun Dai, Man-Jiang Xie, Hua-Feng Kang
Vessel disease is a kind of severe complication in diabetic patients. However, few pharmacologic agents can directly recover diabetic vascular function. Salidroside (SAL), a major ingredient from Rhodiola rosea, has been found to have an obvious hypoglycemic effect and a beneficial protection on vascular function in diabetes. However, whether SAL is a suitable treatment for diabetes has not so far been evaluated and the underlying mechanisms remain unknown. The present work aims to (1) investigate the potential effects of SAL on cerebrovascular relaxation in streptozotocin-induced diabetic rats or when exposed to acute hyperglycemia condition and (2) examine whether function of the BKCa channel is involved in SAL treatment for diabetic vascular relaxation...
August 12, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28791556/the-clinical-implications-of-fatty-pancreas-a-concise-review
#3
REVIEW
Tawfik Khoury, Akwi W Asombang, Tyler M Berzin, Jonah Cohen, Douglas K Pleskow, Meir Mizrahi
Fatty pancreas is a newly recognized condition which is poorly investigated until today as compared to nonalcoholic fatty liver disease. It is characterized by pancreatic fat accumulation and subsequent development of pancreatic and metabolic complications. Association of fatty pancreas have been described with type 2 diabetes mellitus, acute and chronic pancreatitis and even pancreatic carcinoma. In this review article, we provide an update on clinical implications, pathogenesis, diagnosis, treatment and outcomes...
August 8, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28783808/recrudescence-of-deficits-after-stroke-clinical-and-imaging-phenotype-triggers-and-risk-factors
#4
Mehmet A Topcuoglu, Esen Saka, Scott B Silverman, Lee H Schwamm, Aneesh B Singhal
Importance: Reemergence of previous stroke-related deficits (or poststroke recrudescence [PSR]) is an underrecognized and inadequately characterized phenomenon. Objective: To investigate the clinical features, triggers, and risk factors for PSR. Design, Setting, and Participants: This retrospective study incorporated a crossover cohort study to identify triggers and a case-control study to identify risk factors. The study used the Massachusetts General Hospital Research Patient Data Repository to identify patients for the period January 1, 2000, to November 30, 2015, who had a primary or secondary diagnosis of cerebrovascular disease, who underwent magnetic resonance imaging of the brain at least once, and whose inpatient or outpatient clinician note or discharge summary stated the term recrudescence...
August 7, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28780716/epigenetics-a-potential-key-mechanism-involved-in-the-pathogenesis-of-cardiorenal-syndromes
#5
REVIEW
Grazia Maria Virzì, Anna Clementi, Alessandra Brocca, Massimo de Cal, Claudio Ronco
Epigenetics is defined as the heritable changes in gene expression patterns which are not directly encoded by modifications in the nucleotide DNA sequence of the genome, including higher order chromatin organization, DNA methylation, cytosine modifications, covalent histone tail modifications, and short non-coding RNA molecules. Recently, much attention has been paid to the role and the function of epigenetics and epimutations in the cellular and subcellular pathways and in the regulation of genes in the setting of both kidney and cardiovascular disease...
August 5, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28780028/associations-between-chronic-kidney-disease-and-outcomes-with-use-of-prasugrel-versus-clopidogrel-in-patients-with-acute-coronary-syndrome-undergoing-percutaneous-coronary-intervention-a-report-from-the-prometheus-study
#6
Usman Baber, Jaya Chandrasekhar, Samantha Sartori, Melissa Aquino, Annapoorna S Kini, Samir Kapadia, William Weintraub, Joseph B Muhlestein, Birgit Vogel, Michela Faggioni, Serdar Farhan, Sandra Weiss, Craig Strauss, Catalin Toma, Anthony DeFranco, Brian A Baker, Stuart Keller, Mark B Effron, Timothy D Henry, Sunil Rao, Stuart Pocock, George Dangas, Roxana Mehran
OBJECTIVES: The study sought to compare clinical outcomes in a contemporary acute coronary syndrome (ACS) percutaneous coronary intervention (PCI) cohort stratified by chronic kidney disease (CKD) status. BACKGROUND: Patients with CKD exhibit high risks for both thrombotic and bleeding events, thus complicating decision making regarding antiplatelet therapy in the setting of ACS. METHODS: The PROMETHEUS study was a multicenter observational study comparing outcomes with prasugrel versus clopidogrel in ACS PCI patients...
July 27, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28776086/the-mechanisms-of-action-of-metformin
#7
REVIEW
Graham Rena, D Grahame Hardie, Ewan R Pearson
Metformin is a widely-used drug that results in clear benefits in relation to glucose metabolism and diabetes-related complications. The mechanisms underlying these benefits are complex and still not fully understood. Physiologically, metformin has been shown to reduce hepatic glucose production, yet not all of its effects can be explained by this mechanism and there is increasing evidence of a key role for the gut. At the molecular level the findings vary depending on the doses of metformin used and duration of treatment, with clear differences between acute and chronic administration...
August 3, 2017: Diabetologia
https://www.readbyqxmd.com/read/28767577/influence-of-oxygen-content-immediately-after-graft-reperfusion-on-occurrence-of-postoperative-acute-kidney-injury-in-living-donor-liver-transplantation
#8
Min Suk Chae, Nuri Lee, Da Hye Park, Jisoo Lee, Hyun Sik Jung, Chul Soo Park, Jaemin Lee, Jong Ho Choi, Sang Hyun Hong
Acute kidney injury (AKI) is a common complication after living donor liver transplantation (LDLT). In this study, we investigated perioperative factors, including oxygen content, related to the postoperative development of AKI after LDLT. The perioperative data of 334 patients were reviewed retrospectively. We identified the postoperative development of AKI based on the Acute Kidney Injury Network criteria. Perioperative variables, including oxygen content, were compared between patients with and without AKI...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28766722/fatal-diabetic-ketoacidosis-a-potential-complication-of-mdma-ecstasy-use
#9
John D Gilbert, Roger W Byard
A 19-year-old woman with insulin-dependent diabetes mellitus was found dead in bed having allegedly recently taken ecstasy and consumed alcohol. At autopsy, there were microhemorrhages in the brain with subnuclear vacuolization and Armanni-Ebstein changes in renal tubules. Biochemical analyses confirmed diabetic ketoacidosis (vitreous glucose-46.5 mmol/L; β-OH butyrate-13.86 mmol/L.). Toxicological analyses of blood showed a low level of 3,4-methylenedioxy-methamphetamine (MDMA) (0.01 mg/L), with acetone but no alcohol or other common drugs...
August 2, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28764263/acute-pyelonephritis-correlation-of-clinical-parameter-with-radiological-imaging-abnormalities
#10
Leelavathi Venkatesh, Ramalingiah Karadakere Hanumegowda
INTRODUCTION: Pyelonephritis (PN) is a suppurative infection of the kidney, most commonly due to bacterial infection and may be either acute or chronic. Acute PN (APN) subdivided into uncomplicated and complicated. Severity of PN cannot be assessed by clinical or laboratorial parameters alone, radiological imaging such as Ultrasound (USG) abdomen, Computed Tomography (CT) is required to know the nature, extent and severity of disease and for planning interventions. AIM: The aim of this study was to compare clinical and biochemical parameters with radiological findings (USG/CT) among patients diagnosed to have PN...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28761659/the-effect-of-free-diabetes-care-on-metabolic-control-and-on-health-related-quality-of-life-among-youths-with-type-1-diabetes-in-cameroon
#11
Eric Lontchi-Yimagou, Clarisse Mapa-Tassou, Mesmin Y Dehayem, Marie-José Essi, Jude Saji, Remy Takogue, Eugène Sobngwi, Jean Claude Mbanya
OBJECTIVE: To assess the effect of free diabetes care on metabolic control and on health-related quality of life (HRQoL) of youths living with type 1 diabetes in Cameroon. RESEARCH DESIGN AND METHODS: We conducted a clinical audit of a multicenter prospective cohort, performed in three of the nine clinics of the 'Changing Diabetes in Children' (CDiC) project in Cameroon. We collected data on demography, glycemic control, diabetes acute complications, and patients' HRQoL at baseline and after 1 year of follow-up...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28759944/impact-of-health-utility-after-thrombotic-complications-following-total-hip-and-knee-arthroplasty
#12
Bikram Karmakar
BACKGROUND: Medical complications and preexisting conditions frequently place the surgeon in the unenviable position of choosing between the serious and potentially life-threatening effects of thrombosis, or the issue of bleeding and surgical site complications. The aim of this research was to determine if health utility could be a consideration before choosing to therapeutically anticoagulate in the hip and knee arthroplasty patient. METHODS: The quantitative risks and effectiveness of treatment options for venous thromboembolism, atrial fibrillation, acute coronary syndromes, ischaemic stroke and mechanical heart valves were evaluated from previously published data...
July 31, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28757465/mini-encyclopaedia-of-the-wound-healing-opportunities-for-integrating-multi-omic-approaches-into-medical-practice
#13
Lara Stolzenburg-Veeser, Olga Golubnitschaja
Wound healing is a highly complex life-important repair process triggered by plenty of local and/or systemic organ and tissue damaging events, such as an acute surgical invasion, accidental organ and tissue damages, acute and chronic diseases, aggressive local and systemic therapeutic approaches (e.g. irradiation and systemic chemotherapy). Individual health condition determines over the quality of wound healing. Impaired wound healing, in turn, may lead, for example, to post-surgical complications frequently observed in elderly, chronic ulcers in diabetic patients, hindered and ineffective pain management, etc...
July 28, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28757391/systemic-dexmedetomidine-attenuates-mechanical-allodynia-through-extracellular-sign-db-type-2-diabetic-mice
#14
Hui Chen, Xiang Xu, Xiao-Yu Yang, Bing-Yu Ling, He-Ping Sun, Chao Liu, Yu Qiu Zhang, Hong Cao, Lan Xu
Painful diabetic neuropathy (PDN) is a common complication of diabetes mellitus. However, the treatment for PDN is limited in clinical practice. In the present study, we investigated the effect of systemic administration dexmedetomidine (DEX), a selective alpha 2 adrenergic receptor (α2AR) agonist, on mechanical allodynia and its underlying mechanism in db/db mice, an animal model of type 2 diabetes mellitus. Our data demonstrated that db/db mice develop mechanical allodynia at the early stage of diabetes...
July 28, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28754091/-visually-impaired-elderly-patient-ingests-pill-desiccant-leading-to-acute-hypoxic-respiratory-failure-requiring-intubation
#15
Wendy Gerstein, Ziyang Liu
BACKGROUND: A significant percentage of elderly patients suffer from both polypharmacy and visual impairment. This combination can increase the risk of an adverse event related to medication. This case highlights an unusual, but potentially deadly, medication adverse event. CASE PRESENTATION: A 77-year-old male, visually impaired, ingested a pill desiccant, believing it was the ampicillin/sulbactam tablet he was prescribed for an infected diabetic foot ulcer. He presented to the emergency room with inability to swallow, and imaging revealed the pill desiccant lodged in his upper esophagus...
July 28, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28750607/are-women-with-type-2-diabetes-mellitus-more-susceptible-to-cardiovascular-complications-following-coronary-angioplasty-a-meta-analysis
#16
Pravesh Kumar Bundhun, Manish Pursun, Feng Huang
BACKGROUND: Scientific reports have shown Type 2 Diabetes Mellitus (T2DM) to be independently associated with adverse outcomes following Percutaneous Coronary Intervention (PCI). However, gender difference has also often been a controversial issue following PCI. Till date, very few meta-analyses have systematically compared the adverse cardiovascular outcomes in male versus female patients with T2DM following PCI. Therefore, we aimed to carry out this analysis in order to find out an answer to this interesting question...
July 27, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28750429/self-reported-hypoglycaemic-events-in-2%C3%A2-430-patients-with-insulin-treated-diabetes-in-the-german-sub-population-of-the-hat-study
#17
Werner Kern, Andreas Holstein, Christian Moenninghoff, Joachim Kienhöfer, Matthias Riedl, Bernhard Kulzer
Data concerning true hypoglycaemic incidence in insulin-treated patients with diabetes in real-world clinical practice are lacking in Germany. The aim of this analysis was to determine the incidence of hypoglycaemia experienced by the German cohort of patients enrolled in the global Hypoglycaemia Assessment Tool (HAT) study. This was a non-interventional, 6-month retrospective and 4-week prospective study using self-assessment questionnaires and patient diaries assessing patients aged ≥18 years in Germany, with type 1 diabetes (T1D) (n=811) or type 2 diabetes (T2D) (n=1 619) treated with insulin for >12 months...
July 27, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28747349/outcomes-associated-with-a-pediatric-clinical-diabetes-network-in-ontario-a-population-based-time-trend-analysis
#18
Meranda Nakhla, Elham Rahme, Marc Simard, Astrid Guttmann
BACKGROUND: The Network of Ontario Pediatric Diabetes Programs was implemented in 2001. The objective of this study was to determine whether implementation of the network was associated with a decrease in the risk of acute diabetes-related complications and a reduction in the socioeconomic and geographic disparities in these outcomes. METHODS: We conducted a population-based time trend analysis of children (< 18 yr) with diabetes using health administrative databases in Ontario from 1996 to 2011...
July 24, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28746811/the-acute-effects-of-different-spironolactone-doses-on-cardiac-function-in-streptozotocin-induced-diabetic-rats
#19
Aleksandra Vranic, Stefan Simovic, Petar Ristic, Tamara R Nikolic, Isidora Stojic, Ivan M Srejovic, Vladimir I Zivkovic, Vladimir Jakovljevic, Dusan Djuric
Currently, cardiovascular diseases are leading cause of global mortality, while diabetes mellitus remains an important cause of cardiovascular morbidity. Findings suggest that obesity and diabetes mellitus are closely interconnected with high aldosterone levels, while mineralocorticoid receptors antagonist therapy has shown positive effects on cardiovascular complications associated with diabetes mellitus. A recent study showed that patients with diabetes mellitus treated with mineralocorticoid receptors antagonist have improved coronary microvascular function, leading to improved diastolic dysfunction...
July 26, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28742104/serum-neutrophil-gelatinase-associated-lipocalin-the-estimation-of-hospital-prognosis-in-patients-with-st-elevated-myocardial-infarction
#20
Victoria Karetnikova, Anastasia Osokina, Olga Gruzdeva, Evgenya Uchasova, Michael Zykov, Victoria Kalaeva, Vasiliy Kashtalap, Kristina Shafranskaya, Olga Barbarash
We aimed to assess the clinical significance of serum levels of neutrophil gelatinase-associated lipocalin (sNGAL) for predicting in-hospital outcomes in patients with ST-elevated myocardial infarction (STEMI). Patients admitted within 24 hours of developing STEMI clinical symptoms were evaluated for sNGAL on hospitalization days 1 and 12. Recurrent myocardial infarction, early post-infarction angina, acute cerebrovascular accident, and death were assessed as adverse outcomes during hospitalization. The actors associated with adverse outcome were evaluated using univariate and multivariate regression analysis...
2017: PloS One
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