Simon Álvarez, Jose Morales, Paola Tiozzo-Lyon, Pablo Berrios, Valentina Barraza, Kevin Simpson, Andrea Ravasio, Xavier Monforte Vila, Andreas Teuschl-Woller, Christina M A P Schuh, Sebastian Aguayo
Human dentin is a highly organized dental tissue displaying a complex microarchitecture consisting of micrometer-sized tubules encased in a mineralized type-I collagen matrix. As such, it serves as an important substrate for the adhesion of microbial colonizers and oral biofilm formation in the context of dental caries disease, including root caries in the elderly. Despite this issue, there remains a current lack of effective biomimetic in vitro dentin models that facilitate the study of oral microbial adhesion by considering the surface architecture at the micro- and nanoscales...
January 31, 2024: Lab on a Chip