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https://www.readbyqxmd.com/read/28424774/cardiac-radionuclide-imaging-in-rodents-a-review-of-methods-results-and-factors-at-play
#1
Francesco Cicone, David Viertl, Ana Maria Quintela Pousa, Thibaut Denoël, Silvano Gnesin, Francesco Scopinaro, Marie-Catherine Vozenin, John O Prior
The interest around small-animal cardiac radionuclide imaging is growing as rodent models can be manipulated to allow the simulation of human diseases. In addition to new radiopharmaceuticals testing, often researchers apply well-established probes to animal models, to follow the evolution of the target disease. This reverse translation of standard radiopharmaceuticals to rodent models is complicated by technical shortcomings and by obvious differences between human and rodent cardiac physiology. In addition, radionuclide studies involving small animals are affected by several extrinsic variables, such as the choice of anesthetic...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28417829/comparison-of-3-methods-for-preventing-perianesthetic-hypothermia-in-callimicos-callimico-goeldii
#2
Sathya K Chinnadurai James G Johnson Iii And Jennifer N Langan
Perianesthetic hypothermia is one of the most common complications in veterinary anesthesia, especially in small patients with a large body surface area to mass ratio. During anesthesia, body heat can be lost through 4 mechanisms-radiation, convection,conduction, and evaporation-but anesthetists frequently address only one mechanism at a time. Here we sought to evaluate 3 methods of preventing perianesthetic hypothermia in callimicos (Callimico goeldii). In our experience, these smallNHP routinely become hypothermic under even brief inhalant anesthesia...
April 17, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28416648/isoflurane-modulates-activation-and-inactivation-gating-of-the-prokaryotic-na-channel-nachbac
#3
Rheanna M Sand, Kevin J Gingrich, Tamar Macharadze, Karl F Herold, Hugh C Hemmings
Voltage-gated Na(+) channels (Nav) have emerged as important presynaptic targets for volatile anesthetic (VA) effects on synaptic transmission. However, the detailed biophysical mechanisms by which VAs modulate Nav function remain unclear. VAs alter macroscopic activation and inactivation of the prokaryotic Na(+) channel, NaChBac, which provides a useful structural and functional model of mammalian Nav Here, we study the effects of the common general anesthetic isoflurane on NaChBac function by analyzing macroscopic Na(+) currents (INa) in wild-type (WT) channels and mutants with impaired (G229A) or enhanced (G219A) inactivation...
April 17, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28414607/cardiac-arrest-in-an-american-cocker-spaniel-during-a-deep-ear-flush-procedure
#4
Alexandra Gould, Fernando L Garcia-Pereira, W Dunbar Gram
CASE DESCRIPTION A 14-year-old spayed female American Cocker Spaniel with bilateral otitis media and no evidence of cardiovascular instability was anesthetized to allow performance of a deep ear flush. CLINICAL FINDINGS Otoscopic examination of the left ear revealed evidence of chronic inflammation; the ear was flushed with sterile saline (0.9% NaCl) solution. Examination of the right ear revealed more severe chronic inflammation than in the left ear, including a ruptured tympanum (timing of rupture unknown)...
May 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28413517/isoflurane-anesthesia-induces-liver-injury-by-regulating-the-expression-of-insulin-like-growth-factor-1
#5
Yingxian Zhu, Xiaoyu Xiao, Guowei Li, Juyuan Bu, Wenying Zhou, Shaopeng Zhou
It has been suggested that isoflurane may cause perioperative liver injury. However, the mechanism of its action remains unknown. The purpose of the present study was to determine this possible mechanism. Sprague-Dawley rats were randomly assigned into one of three groups (all n=12): Control group (exposed to mock anesthesia), isoflurane group (exposed to 2% isoflurane for 90 min), and isoflurane + insulin-like growth factor 1 (IGF-1) group (exposed to 2% isoflurane for 90 min and then treated with IGF-1). Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blotting were conducted to determine the levels of expression of IGF-1 and its receptor IGF-R...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28403344/cyclosporine-a-attenuates-apoptosis-and-necrosis-after-ischemia-reperfusion-induced-renal-injury-in-transiently-hyperglycemic-rats
#6
Sylvio Valença de Lemos, Isabela Galvão Vianna, Yara Marcondes Machado Castiglia, Marjorie de Assis Golim, Aparecida Vitória Gonçalves de Souza, Lídia Raquel de Carvalho, Elenice Deffune, Paulo do Nascimento, Norma Sueli Pinheiro Módolo, Pedro Thadeu Galvão Vianna
Purpose: To investigate the effects of cyclosporine A on renal ischemia-reperfusion injury during transient hyperglycemia in rats. Methods: In a model of ischemia-reperfusion-induced renal injury and transiently induced hyperglycemia by intraperitoneal injection of glucose, 2.5 g.kg-1, Wistar rats were anesthetized with either isoflurane or propofol and received intravenous cyclosporine A, 5 mg.kg-1, five minutes before reperfusion. Comparison groups were isoflurane and propofol sham groups and isoflurane and propofol ischemia-reperfusion-induced renal injury...
March 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28403230/isoflurane-anesthesia-promotes-cognitive-impairment-by-inducing-expression-of-%C3%AE-amyloid-protein-related-factors-in-the-hippocampus-of-aged-rats
#7
Shuai Zhang, Xueyuan Hu, Wei Guan, Li Luan, Bei Li, Qichao Tang, Honggang Fan
Isoflurane anesthesia has been shown to be responsible for cognitive impairment in Alzheimer's disease (AD) and development of AD in the older age groups. However, the pathogenesis of AD-related cognitive impairments induced by isoflurane anesthesia remains elusive. Thus, this study was designed to investigate the mechanism by which isoflurane anesthesia caused AD-related cognitive impairments. Aged Wistar rats were randomly divided into 6 groups (n = 12), 1 control group (CONT) and 5 isoflurane treated (ISO) groups (ISO 0, ISO 0...
2017: PloS One
https://www.readbyqxmd.com/read/28398813/neural-correlates-of-consciousness-at-near-electrocerebral-silence-in-an-asphyxial-cardiac-arrest-model
#8
Donald E Lee, Lauren G Lee, Danny Siu, Afsheen K Bazrafkan, Maryam H Farahabadi, Tin J Dinh, Josue Orellana, Wei Xiong, Beth A Lopour, Yama Akbari
Recent electrophysiological studies have suggested surges in electrical correlates of consciousness (i.e., elevated gamma power and connectivity) after cardiac arrest (CA). This study examines electrocorticogram (ECoG) activity and coherence of the dying brain during asphyxial CA. Male Wistar rats (n = 16) were induced with isoflurane anesthesia, which was washed out before asphyxial CA. Mean phase coherence and ECoG power were compared during different stages of the asphyxial period to assess potential neural correlates of consciousness...
April 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28392760/accelerated-recovery-of-consciousness-after-general-anesthesia-is-associated-with-increased-functional-brain-connectivity-in-the-high-gamma-bandwidth
#9
Duan Li, Viviane S Hambrecht-Wiedbusch, George A Mashour
Recent data from our laboratory demonstrate that high-frequency gamma connectivity across the cortex is present during consciousness and depressed during unconsciousness. However, these data were derived from static and well-defined states of arousal rather than during transitions that would suggest functional relevance. We also recently found that subanesthetic ketamine administered during isoflurane anesthesia accelerates recovery upon discontinuation of the primary anesthetic and increases gamma power during emergence...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28391757/dose-finding-study-comparing-three-treatments-of-remifentanil-in-cats-anesthetized-with-isoflurane-undergoing-ovariohysterectomy
#10
Marcela L Machado, João Henrique N Soares, Maria Alice Kuster de Albuquerque Gress, Douglas Dos Santos E Castro, Kaleizu Teodoro Rosa, Phillipe Bauer de Araujo Doria, Fabio Otero Ascoli
Objectives Three infusion rates of remifentanil were used in isoflurane-anesthetized cats undergoing ovariohysterectomy. The aim of this study was to identify a dosage regimen that would provide optimal anesthetic and surgical conditions, as well as to compare cardiovascular response to surgical stimulation, postoperative analgesia, anesthetic duration and quality of recovery among the tested remifentanil infusion rates. Methods Twenty-seven client-owned, mixed-breed adult healthy female cats were randomized to receive remifentanil 0...
April 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28391258/dexmedetomidine-combined-with-therapeutic-hypothermia-is-associated-with-cardiovascular-instability-and-neurotoxicity-in-a-piglet-model-of-perinatal-asphyxia
#11
Mojgan Ezzati, Go Kawano, Eridan Rocha-Ferreira, Daniel Alonso-Alconada, Jane K Hassell, Kevin D Broad, Igor Fierens, Bobbi Fleiss, Alan Bainbridge, David L Price, Pardis Kaynezhad, Brian Anderson, Mariya Hristova, Ilias Tachtsidis, Xavier Golay, Pierre Gressens, Robert D Sanders, Nicola J Robertson
The selective α2-adrenoreceptor agonist dexmedetomidine has shown neuroprotective, analgesic, anti-inflammatory, and sympatholytic properties that may be beneficial in neonatal encephalopathy (NE). As therapeutic hypothermia is only partially effective, adjunct therapies are needed to optimize outcomes. The aim was to assess whether hypothermia + dexmedetomidine treatment augments neuroprotection compared to routine treatment (hypothermia + fentanyl sedation) in a piglet model of NE using magnetic resonance spectroscopy (MRS) biomarkers, which predict outcomes in babies with NE, and immunohistochemistry...
April 8, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28390061/should-patients-be-advised-not-to-drive-for-4%C3%A2-days-after-isoflurane-anaesthesia
#12
EDITORIAL
L M Powell, M Molyneux
No abstract text is available yet for this article.
April 8, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28386342/hydrogen-rich-saline-attenuates-isoflurane-induced-caspase-3-activation-and-cognitive-impairment-via-inhibition-of-isoflurane-induced-oxidative-stress-mitochondrial-dysfunction-and-reduction-in-atp-levels
#13
Cheng Li, Lengchen Hou, Dan Chen, Fuqing Lin, Tao Chang, Mengzhu Li, Lingling Zhang, Xiaoyin Niu, Huiying Wang, Shukun Fu, Junhua Zheng
OBJECTIVES: The inhaled general anesthetic isoflurane has been shown to induce caspase-3 activation in vitro and in vivo. The underlying mechanisms and functional consequences of this activity remain unclear. Isoflurane can induce caspase-3 activation by causing accumulation of reactive oxygen species (ROS), mitochondrial dysfunction, and reduction in adenosine triphosphate (ATP) levels. This study aimed to investigate the protective effect of hydrogen, a novel antioxidant, against isoflurane-induced caspase-3 activation and cognitive impairment...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28384319/correction-antidepressant-and-neurocognitive-effects-of-isoflurane-anesthesia-versus-electroconvulsive-therapy-in-refractory-depression
#14
Howard R Weeks, Scott C Tadler, Kelly W Smith, Eli Iacob, Mikala Saccoman, Andrea T White, Joshua D Landvatter, Gordon J Chelune, Yana Suchy, Elaine Clark, Michael K Cahalan, Lowry Bushnell, Derek Sakata, Alan R Light, Kathleen C Light
[This corrects the article DOI: 10.1371/journal.pone.0069809.].
2017: PloS One
https://www.readbyqxmd.com/read/28384227/differential-modulation-of-thalamo-parietal-interactions-by-varying-depths-of-isoflurane-anesthesia
#15
Dongrae Cho, Teo Jeon Shin, Jinsil Ham, Dong-Hyuk Choi, Seonghyun Kim, Seongwook Jeong, Hyoung-Ihl Kim, Jae Gwan Kim, Boreom Lee
The thalamus is thought to relay peripheral sensory information to the somatosensory cortex in the parietal lobe. Long-range thalamo-parietal interactions play an important role in inducing the effect of anesthetic. However, whether these interaction changes vary with different levels of anesthesia is not known. In the present study, we investigated the influence of different levels of isoflurane-induced anesthesia on the functional connectivity between the thalamus and the parietal region. Microelectrodes were implanted in rats to record local field potentials (LFPs)...
2017: PloS One
https://www.readbyqxmd.com/read/28381818/dronedarone-attenuates-the-duration-of-atrial-fibrillation-in-a-dog-model-of-sustained-atrial-fibrillation
#16
Nakkawee Saengklub, Vudhiporn Limprasutr, Suwanakiet Sawangkoon, Robert L Hamlin, Anusak Kijtawornrat
Atrial fibrillation (AF) is a supraventricular arrhythmia that leads to a decrease in cardiac output and impairs cardiac function and quality of life. Dronedarone has an atrial-selective property and has been used for management of AF in humans, but limited information is available in dogs. This study was designed to evaluate efficacy of dronedarone in attenuating the duration of AF in dog model of sustained AF. Six beagle dogs were anesthetized with isoflurane and instrumented to measure atrial action potential duration (aAPD) and atrial effective refractory period (AERP)...
April 4, 2017: Experimental Animals
https://www.readbyqxmd.com/read/28381314/effect-of-isoflurane-anesthesia-on-circadian-metabolism-and-physiology-in-rats
#17
Melissa A Wren-Dail, Robert T Dauchy, David E Blask, Steven M Hill, Tara G Ooms, Lynell M Dupepe, Rudolf P Bohm
Isoflurane anesthesia alters the blood levels of several neuroendocrine hormones associated with normal metabolism and physiology and increases stress, but the effect of brief CO2 anesthesia on these parameters is unknown. In this study, we examined the effects of isoflurane (4%) compared with brief CO2 (70% CO2, 30% air) anesthesia on circadian rhythms of plasma measures of physiology and metabolism. Adult male Sprague-Dawley rats (Crl:SD; n = 6 per group) were maintained on a 12:12-h light:dark (300 lx; lights on, 0600) photoperiod...
March 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28380075/repeated-brief-isoflurane-anesthesia-during-early-postnatal-development-produces-negligible-changes-on-adult-behavior-in-male-mice
#18
Marko Rosenholm, Emmi Paro, Hanna Antila, Vootele Võikar, Tomi Rantamäki
Brain development is a complex process regulated by genetic programs and activity-dependent neuronal connectivity. Anesthetics profoundly alter neuronal excitability, and anesthesia during early brain development has been consistently associated with neuroapoptosis, altered synaptogenesis, and persistent behavioral abnormalities in experimental animals. However, the depth, and even more the duration and developmental time point(s) of exposure to anesthesia determine the neuropathological and long-term behavioral consequences of anesthetics...
2017: PloS One
https://www.readbyqxmd.com/read/28378088/central-activation-of-the-a1-adenosine-receptor-in-fed-mice-recapitulates-only-some-of-the-attributes-of-daily-torpor
#19
Maria A Vicent, Ethan D Borre, Steven J Swoap
Mice enter bouts of daily torpor, drastically reducing metabolic rate, core body temperature (T b), and heart rate (HR), in response to reduced caloric intake. Because central adenosine activation has been shown to induce a torpor-like state in the arctic ground squirrel, and blocking the adenosine-1 (A1) receptor prevents daily torpor, we hypothesized that central activation of the A1 adenosine receptors would induce a bout of natural torpor in mice. To test the hypothesis, mice were subjected to four different hypothermia bouts: natural torpor, forced hypothermia (FH), isoflurane-anesthesia, and an intracerebroventricular injection of the selective A1 receptor agonist N(6-)cyclohexyladenosine (CHA)...
April 4, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28377845/time-dependent-decline-in-multifocal-electroretinogram-requires-faster-recording-procedures-in-anesthetized-pigs
#20
Nina Buus Sørensen, Anders Tolstrup Christiansen, Troels Wesenberg Kjær, Kristian Klemp, Morten la Cour, Jens Folke Kiilgaard
PURPOSE: The time-dependent effect of anesthetics on the retinal function is debated. We hypothesize that in anesthetized animals there is a time-dependent decline that requires optimized multifocal electroretinogram (mfERG) recording procedures. METHODS: Conventional and four-frame global-flash mfERG recordings were obtained approximately 15, 60, and 150 minutes after the induction of propofol anesthesia (20 pigs) and isoflurane anesthesia (nine pigs). In six of the propofol-anesthetized pigs, the mfERG recordings were split in 3-minute segments...
March 2017: Translational Vision Science & Technology
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