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Anaplastic thyroid cancer

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https://www.readbyqxmd.com/read/27896549/embryonal-rhabdomyosarcoma-in-a-patient-with-a-heterozygous-frameshift-variant-in-the-dicer1-gene-and-additional-manifestations-of-the-dicer1-syndrome
#1
Julia Fremerey, Stefan Balzer, Triantafyllia Brozou, Joerg Schaper, Arndt Borkhardt, Michaela Kuhlen
Germline mutations in the DICER1 gene are associated with an inherited cancer predisposition syndrome also known as the DICER1-syndrome, which is implicated in a broad range of tumors including pleuropulmonary blastoma, ovarian Sertoli-Leydig cell tumors, ciliary body medulloepithelioma (CBME), pituitary blastoma, embryonal rhabdomyosarcoma (eRMS), anaplastic renal sarcoma as well as ocular, sinonasal tumors ovarian sex-cord tumors, thyroid neoplasia and cystic nephroma. This study describes a novel, heterozygous frameshift DICER1 mutation in a patient, who is affected by different tumors of the DICER1-syndrome, including eRMS, CBME and suspected pleuropulmonary blastoma type I...
November 28, 2016: Familial Cancer
https://www.readbyqxmd.com/read/27885512/clinicopathological-features-of-thyroid-cancer-in-the-elderly-compared-to-younger-counterparts-single-center-experience
#2
F D Dellal, D Özdemir, A A Tam, H Baser, H Tatli Dogan, O Parlak, R Ersoy, B Cakir
PURPOSE: The incidence of thyroid cancer is increased in elderly patients. It tends to be larger and have more aggressive characteristics in these patients. Our aim was to compare features of thyroid carcinoma in geriatric and non-geriatric patients. METHODS: In total, 933 patients with thyroid cancer were retrospectively reviewed. Thyroid functions, ultrasonography features of malignant nodules, cytological and histopathological findings and the rates of recurrence and persistence were compared in patients ≥65 and <65 years old...
November 24, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27880942/acquired-resistance-to-braf-inhibition-induces-epithelial-to-mesenchymal-transition-in-braf-v600e-mutant-thyroid-cancer-by-c-met-mediated-akt-activation
#3
Hyung Kwon Byeon, Hwi Jung Na, Yeon Ju Yang, Sooah Ko, Sun Och Yoon, Minhee Ku, Jaemoon Yang, Jae Wook Kim, Myung Jin Ban, Ji-Hoon Kim, Da Hee Kim, Jung Min Kim, Eun Chang Choi, Chang-Hoon Kim, Joo-Heon Yoon, Yoon Woo Koh
Previously, the authors have identified that c-Met mediates reactivation of the PI3K/AKT pathway following BRAF inhibitor treatment in BRAF (V600E) mutant anaplastic thyroid cancer, thereby contributing to the acquired drug resistance. Therefore dual inhibition of BRAF and c-Met led to sustained treatment response, thereby maximizing the specific anti-tumor effect of targeted therapy. The present study goes one step further and aims to investigate the effect of acquired resistance of BRAF inhibitor on epithelial-to-mesenchymal transition (EMT) in BRAF mutant thyroid cancer cells and the effect of dual inhibition from combinatorial therapy...
November 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27872133/thyroid-metastasis-from-lung-adenocarcinoma-with-eml4-alk-rearrangement
#4
Hironori Kawamoto, Yugo Kaneko, Kai Ryu, Kazuyoshi Kuwano
Thyroid metastases from lung cancer are very rare. A woman aged 42 years with a tumour in the lower lobe of the right lung was diagnosed as having lung adenocarcinoma positive for echinoderm microtubule-associated proteinlike 4-anaplastic lymphoma kinase. Positron emission tomography demonstrated fluorodeoxyglucose accumulation in the lower lobe of the right lung, the right thyroid lobe and both adrenal glands. We performed fine-needle aspiration biopsy (FNAB) and used reverse transcriptase-PCR (RT-PCR) to diagnose the patient as having metastatic lung adenocarcinoma to the thyroid gland...
November 21, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27870581/everolimus-in-patients-with-advanced-follicular-derived-thyroid-cancer-results-of-a-phase-ii-clinical-trial
#5
T C Schneider, D de Wit, T P Links, N P van Erp, J J M van der Hoeven, H Gelderblom, C F M Roozen, M Bos, W E Corver, T van Wezel, J W A Smit, H Morreau, H J Guchelaar, E Kapiteijn
BACKGROUND: mTOR upregulation has been reported to be involved in the pathogenesis of thyroid tumors and treatment with the mTOR inhibitor everolimus has shown promising results in endocrine tumors. We conducted a prospective phase II clinical trial to determine the efficacy and safety of everolimus in patients with advanced differentiated thyroid cancer. PATIENTS AND METHODS: Twenty-eight patients with progressive metastatic or locally advanced radioactive refractory differentiated thyroid cancer and 7 patients with anaplastic thyroid cancer were included and received everolimus 10mg orally once daily...
November 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27869424/-study-of-medullary-thyroid-carcinoma-from-a-proband
#6
Laura Morlán Herrador, Antonio de Arriba, Gloria Miguel, Marta Ferrera, José I Labarta
Thyroid cancer is an uncommon type of cancer, accounting less than 1% of all cancers in adults, and 0.5-3% of all cancers in children. There are four different types: papillary carcinoma (80-90% of cases), follicular (5-10%), medullary (5%) and anaplastic cell (2-3%). Eighty per cent of cases of medullary thyroid cancer are sporadic, but 20% are associated with an inherited syndrome that is divided into three groups: multiple endocrine neoplasia type 1, multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma...
December 1, 2016: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/27853625/targeting-of-slug-sensitizes-anaplastic-thyroid-carcinoma-sw1736-cells-to-doxorubicin-via-puma-upregulation
#7
Anbing Dong, Xuelong Jiao, Dong Chen, Fengyun Hao, Kejun Zhang
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human cancers and often shows resistance to multimodal therapeutic approaches. It has been shown that the transcriptional repressor Slug inhibits the chemotherapeutic agent-induced apoptosis of cancer cells. We evaluated whether targeting of Slug could augment doxorubicin (DOX)-induced apoptosis of ATC cells. We also determined changes in PUMA (p53-upregulated modulator of apoptosis) expression levels to identify possible mechanisms of their combined actions...
2016: International Journal of Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27847111/the-epstein-barr-virus-ebna2-protein-induces-a-subset-of-notch-target-genes-in-thyroid-cancer-cell-lines-but-fails-to-suppress-proliferation
#8
Sean Golden, Xiao-Min Yu, Scott Odorico, Vansh Jain, Ana Marin, Shidong Ma, Shannon Kenney, Herbert Chen
BACKGROUND: Epstein-Barr virus is associated with lymphoid and epithelial malignancies and has been reported to infect thyroid cells. The Epstein-Barr virus protein, EBNA2, regulates viral and cellular promoters by binding to RBP-jκ. Similarly, NOTCH1, a tumor suppressor protein in thyroid epithelial cells, competes with EBNA2 for binding to overlapping sites on RBP-jκ. EBNA2 activates a subset of NOTCH-responsive genes in lymphocytes and myocytes; however, the effect of EBNA2 expression on NOTCH targets in epithelial cells is unknown...
November 12, 2016: Surgery
https://www.readbyqxmd.com/read/27833978/primary-squamous-cell-carcinoma-of-the-thyroid-a-case-report
#9
Corina Lichiardopol, Valeriu Şurlin, Maria Camelia Foarfă, Mirela Corina Ghiluşi, Simona Bondari
Primary squamous cell carcinoma of the thyroid is a very rare thyroid malignancy (less than 1% of thyroid cancers) with unfavorable clinical evolution and median survival less than one year, due to highly local tumor invasiveness with airway obstruction, metastases and treatment complications. We present a 62-year-old female patient with a fixed, rapidly increasing 5 cm right thyroid nodule, generating compressive signs and significant weight loss, resembling anaplastic thyroid carcinoma. Thyroid hormones, antithyroid antibodies and calcitonin were normal...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27832468/nodular-thyroid-disease-in-the-elderly-novel-molecular-approaches-for-the-diagnosis-of-malignancy
#10
REVIEW
Salvatore Sorrenti, Enke Baldini, Francesco Tartaglia, Antonio Catania, Stefano Arcieri, Daniele Pironi, Pier Giorgio Calò, Angelo Filippini, Salvatore Ulisse
Epithelial thyroid cancers (TC) comprise two differentiated histotypes (DTC), the papillary (PTC) and the follicular (FTC) thyroid carcinomas which, following dedifferentiation, are assumed to give rise to the poorly differentiated thyroid carcinomas and the rare, but highly aggressive and invariably fatal, anaplastic thyroid carcinomas. Although thyroid cancer mortality has not been changed, its annual incidence has increased over the last two decades, mainly because of the improved ability to diagnose malignant transformation in small non-palpable thyroid nodules...
November 10, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27829536/anticancer-activity-of-all-trans-retinoic-acid-loaded-liposomes-on-human-thyroid-carcinoma-cells
#11
Maria Chiara Cristiano, Donato Cosco, Christian Celia, Andra Tudose, Rosario Mare, Donatella Paolino, Massimo Fresta
All-trans retinoic acid (ATRA) is an anti-tumor compound, exerting different anti-cancer effects on different types of cancer cells. Unfortunately, retinoids are also characterized by certain side effects following systemic administration, such as the burning of skin and general malaise. The highly variable degree of bioavailability of ATRA plus its tendency to induce its own destruction through metabolic degradation following oral treatment necessitate the development of alternative formulations. The aim of this work is to evaluate the physico-chemical properties of unilamellar, ATRA-containing liposomes and to investigate the cytotoxic activity of this potential nanomedicine on human thyroid carcinoma cells...
November 4, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27805390/insights-of-a-lead-optimization-study-and-biological-evaluation-of-novel-4-hydroxytamoxifen-analogs-as-estrogen-related-receptor-gamma-err%C3%AE-inverse-agonists
#12
Jina Kim, Seo Yeon Woo, Chun Young Im, Eun Kyung Yoo, Seung Mi Lee, Hyo-Ji Kim, Hee-Jong Hwang, Joong-Heui Cho, Won Seok Lee, Heeseok Yoon, Shinae Kim, Oh-Bin Kwon, Hayoung Hwang, Kyung-Hee Kim, Jae-Han Jeon, Thoudam Debraj Singh, Sang Wook Kim, Sung Yeoun Hwang, Hueng-Sik Choi, In-Kyu Lee, Seong Heon Kim, Yong Hyun Jeon, Jungwook Chin, Sung Jin Cho
We evaluated the in vitro pharmacology as well as the absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of chemical entities that have not only shown to be highly selective agonists for ERR, but also exhibited enhanced pharmacokinetic profile than 3 (GSK5182). 6g and 10b had comparable potency to 3 and were far more selective for ERR over the ERRα, βand ERαThe in vivo pharmacokinetic profiles of 6g and 10b were further evaluated as they possessed superior in vitro ADMET profiles compared to the other compounds...
November 2, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27803906/endosonographic-examination-of-thyroid-gland-among-patients-with-nonthyroid-cancers
#13
Amer A Alkhatib, Abdulah A Mahayni, Ghaleb R Chawki, Leon Yoder, Fateh A Elkhatib, Mohammad Al-Haddad
OBJECTIVES: There is limited endosonographic literature regarding thyroid gland pathology, which is frequently visualized during upper endoscopic ultrasound (EUS). Our objective was to assess the prevalence of benign and malignant thyroid lesions encountered during routine upper EUS within a cancer center setting. MATERIALS AND METHODS: The data were prospectively collected and retrospectively analyzed. All upper EUS procedures performed between October 2012 and July 2014 were reviewed at a large referral cancer center...
September 2016: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/27802204/knockdown-of-s100a4-blocks-growth-and-metastasis-of-anaplastic-thyroid-cancer-cells-in-vitro-and-in-vivo
#14
Kejun Zhang, Meiqin Yu, Fengyun Hao, Anbing Dong, Dong Chen
Anaplastic thyroid cancer (ATC) is a locally aggressive type of thyroid tumor with high rate of distant metastases. It is often incurable because it does not respond to radioiodine, radiotherapy, or chemotherapy. With conventional treatment, the median survival is about 6 months; therefore, new treatment options are needed. S100A4 is a calcium-binding protein related to the metastatic potential of carcinoma. Previous study has found S100A4 was overexpressed in human papillary thyroid carcinomas (PTC) tissues, and overexpression of S100A4 is associated with thyroid tumour invasion and metastasis...
September 26, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27799794/lenvatinib-and-other-tyrosine-kinase-inhibitors-for-the-treatment-of-radioiodine-refractory-advanced-and-progressive-thyroid-cancer
#15
REVIEW
Loredana Lorusso, Letizia Pieruzzi, Agnese Biagini, Elena Sabini, Laura Valerio, Carlotta Giani, Paolo Passannanti, Benedetta Pontillo-Contillo, Valentina Battaglia, Salvatore Mazzeo, Eleonora Molinaro, Rossella Elisei
Lenvatinib is a small oral molecule able to inhibit three of the extracellular and intracellular molecules involved in the modulation of angiogenesis and lymphangiogenesis: vascular endothelial growth factor receptor 1-3, fibroblast growth factor receptor 1-4, and platelet-derived growth factor receptor alpha. Since it is also able to inhibit the REarranged during Transfection oncogene and the protooncogene c-KIT, this drug can also be used to control tumor cell proliferation. The maximum tolerated dose, as demonstrated in Phase I studies, is 25 mg daily...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27797976/genomic-heterogeneity-and-exceptional-response-to-dual-pathway-inhibition-in-anaplastic-thyroid-cancer
#16
William J Gibson, Daniel T Ruan, Vera A Paulson, Justine A Barletta, Glenn J Hanna, Stefan Kraft, Antonio Calles, Matthew A Nehs, Francis D Moore, Amaro Taylor-Weiner, Jeremiah A Wala, Travis I Zack, Thomas C Lee, Fiona M Fennessy, Erik K Alexander, Tom Tomas, Pasi A Janne, Levi A Garraway, Scott L Carter, Rameen Beroukhim, Jochen H Lorch, Eliezer Van Allen
PURPOSE: Cancers may resist single-agent targeted therapies when the flux of cellular growth signals is shifted from one pathway to another. Blockade of multiple pathways may be necessary for effective inhibition of tumor growth. We document a case in which a patient with anaplastic thyroid carcinoma (ATC) failed to respond to either mTOR or combined RAF/MEK inhibition, but experienced a dramatic response when both drug regimens were combined. EXPERIMENTAL DESIGN: Multi-region whole-exome sequencing of five diagnostic and four autopsy tumor biopsies was performed...
October 17, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27796151/cell-cycle-m-phase-genes-are-highly-upregulated-in-anaplastic-thyroid-carcinoma
#17
Paul Weinberger, Sithara Raju Ponny, Hongyan Xu, Shan Bai, Robert C Smallridge, John A Copland, Ashok Sharma
<b>Background:</b> Anaplastic thyroid carcinoma (ATC) accounts for only 3% of thyroid cancers, yet strikingly it accounts for almost 40% of thyroid cancer deaths. Currently, no effective therapies exist. In an effort to identify ATC-specific therapeutic targets, we analyzed global gene expression data from multiple studies to identify ATC specific dysregulated genes. <b>Methods:</b> The NCBI Gene Expression Omnibus database was searched for high-throughput gene expression microarray studies from human ATC tissue along with normal thyroid and/or papillary thyroid cancer (PTC) tissue...
October 31, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27785980/real-time-genomic-characterization-utilizing-circulating-cell-free-dna-in-patients-with-anaplastic-thyroid-carcinoma
#18
Vlad C Sandulache, Michelle D Williams, Stephen Y Lai, Charles Lu, William N William, Naifa L Busaidy, Gilbert J Cote, Rajesh R Singh, Rajyalakshmi Luthra, Maria E Cabanillas
BACKGROUND: Anaplastic thyroid carcinoma (ATC) is an aggressive disease that requires rapid diagnosis and multimodality treatment. Recent advances in targeted therapeutics have provided ATC patients with previously unavailable treatment options, which may improve clinical outcomes in the coming years. Continued development of high-throughput next-generation sequencing provides clinicians with an unparalleled ability to characterize the genomic background of tumors in order to guide treatment selection and clinical trial enrollment...
November 29, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27785922/inhibition-of-mnk-eif4e-pathway-sensitizes-the-efficacy-to-chemotherapy-in-anaplastic-thyroid-cancer
#19
Kun Hu, Juan Zhang, Min Yu, Chang'e Xiong
AIM: We investigated whether MAPK-interacting kinase (Mnk) inhibition sensitizes anaplastic thyroid cancer (ATC) cellular response to chemotherapy. MATERIALS & METHODS: In vitro and in vivo methods were used to examine the combinatory effects of cisplatin with Mnk inhibition and its underlying mechanism. RESULTS: Mnk inhibition by pharmacological or genetic approaches inhibits proliferation and induces apoptosis of ATC cells and enhances the effects of cisplatin in in vitro and in vivo...
October 27, 2016: Future Oncology
https://www.readbyqxmd.com/read/27779717/mir-148a-inhibits-self-renewal-of-thyroid-cancer-stem-cells-via-repressing-ino80-expression
#20
Weizhong Sheng, Yusheng Chen, Yuda Gong, Tiangeng Dong, Bo Zhang, Weidong Gao
Anaplastic thyroid carcinoma (ATC) is aggressive and lethal with extrathyroidal invasion, distant metastasis, and resistance to conventional therapies. Cancer stem cells (CSCs) are proposed to be responsible for high recurrence rate in ATC. MicroRNAs (miRNAs) have recently been found as an important class of cellular regulators of ATC carcinogenesis. Identification of CSC-related miRNAs and targets is therefore a priority for the development of new therapeutic paradigms. Patient-derived ATC cells were cultured in conditional media on poly-hema-treated dish...
October 25, 2016: Oncology Reports
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