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Adrenocortical cancer

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https://www.readbyqxmd.com/read/29650402/proprotein-convertase-subtilisin-kexin-type-9-pcsk9-inhibitor-use-in-the-management-of-resistant-hypercholesterolemia-induced-by-mitotane-treatment-for-adrenocortical-cancer
#1
Efthymia D Tsakiridou, Evangelos Liberopoulos, Zoe Giotaki, Stelios Tigas
We report the case of a patient with probable heterozygous familial hypercholesterolemia and mitotane-induced resistant hypercholesterolemia, despite combination therapy with rosuvastatin and ezetimibe. The patient was managed with the addition of evolocumab. Use of a proprotein convertase subtilisin-kexin type 9 inhibitor, should be considered in patients who develop mitotane-related hypercholesterolemia that cannot be managed with conventional lipid-lowering treatment.
March 13, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29630043/characterization-of-cell-membrane-extensions-and-studying-their-roles-in-cancer-cell-adhesion-dynamics
#2
Taylor C Brown, Norman G Nicolson, Joyce Cheng, Reju Korah, Tobias Carling
The cell membrane's extension repertoire modulates various malignant behaviors of cancer cells, including their adhesive and migratory potentials. The ability to accurately classify and quantify cell extensions and measure the effect on a cell's adhesive capacity is critical to determining how cell-signaling events impact cancer cell behavior and aggressiveness. Here, we describe the in vitro design and use of a cell extension quantification method in conjunction with an adhesion capacity assay in an established in vitro model for adrenocortical carcinoma (ACC)...
March 26, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29532999/nutlin-3a-as-a-novel-anticancer-agent-for-adrenocortical-carcinoma-with-ctnnb1-mutation
#3
Wen Hui, Shenghua Liu, Jie Zheng, Zujun Fang, Qiang Ding, Chenchen Feng
Adrenocortical carcinoma (ACC) is a rare malignancy, and CTNNB1 is frequently mutated in ACC. Our study aims to screen for effective agents with antineoplastic activity against ACC with CTNNB1 mutation. In-silico screening of the Genomics of Drug Sensitivity in Cancer (GDSC) database was conducted. Drug sensitivity in cells with CTNNB1 mutation was analyzed and further in vitro and in vivo studies were performed using the compound. Only one compound, Nutlin-3a, an MDM2 inhibitor, was significantly sensitive in 18 cancer cells with CTNNB1 mutation...
March 13, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29516499/mir-483-5p-and-mir-139-5p-promote-aggressiveness-by-targeting-n-myc-downstream-regulated-gene-family-members-in-adrenocortical-cancer
#4
Claire Agosta, Jonathan Laugier, Laurent Guyon, Josiane Denis, Jérôme Bertherat, Rossella Libé, Bruno Boisson, Nathalie Sturm, Jean-Jacques Feige, Olivier Chabre, Nadia Cherradi
Adrenocortical carcinoma (ACC) is a tumor with poor prognosis in which overexpression of a panel of microRNAs has been associated with malignancy but a very limited number of investigations on their role in ACC pathogenesis have been conducted. We examined the involvement of miR-483-5p and miR-139-5p in adrenocortical cancer aggressiveness. Using bioinformatics predictions and mRNA/miRNA expression profiles, we performed an integrated analysis to identify inversely correlated miRNA-mRNA pairs in ACC. We identified N-Myc Downstream-Regulated Gene family members 2 and 4 (NDRG2 and NDRG4) as targets of miR-483-5p and miR-139-5p, respectively...
March 8, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29515971/the-expression-and-prognostic-impact-of-immune-cytolytic-activity-related-markers-in-human-malignancies-a-comprehensive-meta-analysis
#5
Constantinos Roufas, Dimitrios Chasiotis, Anestis Makris, Christodoulos Efstathiades, Christos Dimopoulos, Apostolos Zaravinos
Background: Recently, immune-checkpoint blockade has shown striking clinical results in different cancer patients. However, a significant inter-individual and inter-tumor variability exists among different cancers. The expression of the toxins granzyme A (GZMA) and perforin 1 (PRF1), secreted by effector cytotoxic T cells and natural killer (NK) cells, were recently used as a denominator of the intratumoral immune cytolytic activity (CYT). These levels are significantly elevated upon CD8+ T-cell activation as well as during a productive clinical response against immune-checkpoint blockade therapies...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29500765/impact-of-micro-and-macroscopically-positive-surgical-margins-on-survival-after-resection-of-adrenocortical-carcinoma
#6
Kevin L Anderson, Mohamed A Adam, Samantha M Thomas, Linda Youngwirth, Michael T Stang, Randall P Scheri, Sanziana A Roman, Julie A Sosa
PURPOSE: Adrenocortical carcinoma (ACC) is a rare, aggressive cancer; complete surgical resection offers the best chance for long-term survival. The impact of surgical margin status on survival is poorly understood. Our objective was to determine the association of margin status with survival. METHODS: Patients with ACC were identified from the National Cancer Data Base, 1998-2012, and stratified based on surgical margin status (negative vs. microscopically positive [+] vs...
March 2, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29475877/management-of-endocrine-disease-adrenocortical-carcinoma-differentiating-the-good-from-the-poor-prognosis-tumors
#7
Anne Jouinot, Jerome Bertherat
Adrenocortical carcinoma (ACC) is a rare malignancy with a poor prognosis, the five-years overall survival being below 40%. However there is great variability of outcomes and we have now a better view of the heterogeneity of tumor aggressiveness. The extent of the disease at the time of diagnosis, best assayed by the European Network for the Study of Adrenal Tumors (ENSAT) staging score, is a major determinant of survival. The tumor grade, including the mitotic count and the Ki67 proliferation index, also appears as a strong prognostic factor...
February 23, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29474877/the-grp78-bip-inhibitor-ha15-synergizes-with-mitotane-action-against-adrenocortical-carcinoma-cells-through-convergent-activation-of-er-stress-pathways
#8
Carmen Ruggiero, Mabrouka Doghman-Bouguerra, Cyril Ronco, Rachid Benhida, Stéphane Rocchi, Enzo Lalli
Many types of cancer cells present constitutively activated ER stress pathways because of their significant burden of misfolded proteins coded by mutated and rearranged genes. Further increase of ER stress by pharmacological intervention may shift the balance towards cell death and can be exploited therapeutically. Recent studies have shown that an important component in the mechanism of action of mitotane, the only approved drug for the medical treatment of adrenocortical carcinoma (ACC), is represented by activation of ER stress through inhibition of the SOAT1 enzyme and accumulation of toxic lipids...
February 20, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29461221/bilateral-adrenocortical-carcinoma-case-report-and-review-of-literature
#9
D Nikoleishvili, G Koberidze, M Kutateladze, G Zumbadze, A Mariamidze
Adrenocortical carcinoma is a very rare and aggressive endocrinological malignancy arising from the adrenal cortex. The estimated incidence is 1 per million people, with an estimated 5-year survival rate of 16-47%. It can be bilateral in roughly 2-10% of cases, but the data is scarce and there is no conclusive evidence whether the contralateral mass is an independent tumor or a metastasis from the other adrenal gland cancer. Radical surgical excision is the only curative treatment. Therefore, careful pre- and intraoperative surgical planning is critically important...
January 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29429354/-pathogenic-and-diagnostic-roles-of-micrornas-in-adrenocortical-tumours
#10
Zoltán Nagy, Ábel Decmann, Pál Perge, Péter Igaz
Adrenocortical tumours are quite prevalent. Most of these tumours are benign, hormonally inactive adrenocortical adenomas. Rare hormone-secreting adrenocortical adenomas are associated with severe clinical consequences, whereas the prognosis of the rare adrenocortical cancer is rather poor in its advanced stages. The pathogenesis of these tumours is only partly elucidated. MicroRNAs are small, non-coding RNA molecules that are pivotal in the regulation of several basic cell biological processes via the posttranscriptional regulation of gene expression...
February 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29411361/targeting-the-multidrug-transporter-patched-potentiates-chemotherapy-efficiency-on-adrenocortical-carcinoma-in-vitro-and-in-vivo
#11
Anida Hasanovic, Carmen Ruggiero, Sara Jung, Ida Rapa, Laurie Signetti, Monia Ben Hadj, Massimo Terzolo, Felix Beuschlein, Marco Volante, Constanze Hantel, Enzo Lalli, Isabelle Mus-Veteau
One of the crucial challenges in the clinical management of cancer is the resistance to chemotherapeutics. We recently demonstrated that the Hedgehog receptor Patched, which is overexpressed in many recurrent and metastatic cancers, is a multidrug transporter for chemotherapeutic agents such as doxorubicin. The present work provides evidences that Patched is expressed in adrenocortical carcinoma (ACC) patients, and is a major player of the doxorubicin efflux and the doxorubicin resistance in the human ACC cell line H295R...
February 7, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29385886/during-stress-heart-rate-variability-moderates-the-impact-of-childhood-adversity-in-women-with-breast-cancer
#12
Dina Tell, Herbert L Mathews, Robert L Burr, Linda Witek Janusek
Childhood adversity has long-lasting neuro-biological effects that can manifest as exaggerated stress responsivity to environmental challenge. These manifestations include a dysregulated hypothalamic-pituitary-adrenocortical (HPA) axis as well as increased levels of inflammatory mediators in response to stress. In this investigation, vagal parasympathetic activity was assessed for its capacity to moderate the relationship between childhood adversity and stress responsivity (cortisol and inflammation) during an acute laboratory challenge (Trier Social Stress Test-TSST)...
February 1, 2018: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29383185/gper-independent-inhibition-of-adrenocortical-cancer-growth-by-g-1-involves-ros-egr-1-bax-pathway
#13
Ivan Casaburi, Paola Avena, Arianna De Luca, Rosa Sirianni, Vittoria Rago, Adele Chimento, Francesca Trotta, Carmela Campana, William E Rainey, Vincenzo Pezzi
We previously demonstrated that treatment of the H295R adrenocortical cancer cell line with the non-steroidal, high-affinity GPER (G protein-coupled estrogen receptor 1) agonist G-1 reduced tumor growth in vitro and in vivo through a GPER independent action. Moreover, we observed that G-1 treatment induces cell-cycle arrest and apoptosis following a sustained ERK1/2 activation. However, the precise mechanisms causing these effects were not clarified. Starting from our preliminary published results, we performed a microarray study that clearly evidenced a strong and significative up-regulation of EGR-1 gene in H295R cells treated for 24h with micromolar concentration of G-1...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29383116/overexpression-of-hsd17b4-exerts-tumor-suppressive-function-in-adrenocortical-carcinoma-and-is-not-associated-with-hormone-excess
#14
Guanxiong Ding, Shenghua Liu, Qiang Ding, Chenchen Feng
Aim: Adrenocortical carcinoma (ACC) is characterized with excessive hormone production. We therefore investigated expression of hormone-related genes in ACC. Results: We queried status of 14 key genes directly involved in adrenal hormone production and found HSD17B4 expression was upregulated in 39% of ACC cases on top of all queried genes. Overexpression of HSD17B4 was significantly associate with a normo-hormonal phenotype. Constitutive HSD17B4 expression was higher in ACC cell line NCI-H295R than in adrenocortical small cell carcinoma cell line SW13...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29377868/characteristics-of-adrenal-masses-in-familial-adenomatous-polyposis
#15
Jonah S Shiroky, Jordan P Lerner-Ellis, Anand Govindarajan, David R Urbach, Karen M Devon
BACKGROUND: Adrenal masses are a known extraintestinal manifestation of familial adenomatous polyposis. However, the literature on this association is largely confined to case reports. OBJECTIVE: This study aimed to determine the characteristics of adrenal masses in familial adenomatous polyposis and their clinical significance, as well as to estimate their prevalence. Mutational analysis was conducted to determine if any potential genotype-phenotype correlations exist...
January 24, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29371329/development-of-new-preclinical-models-to-advance-adrenocortical-carcinoma-research
#16
Katja Kiseljak-Vassiliades, Yu Zhang, Stacey Bagby, Adwitiya Kar, Nikita Pozdeyev, Mei Xu, Katherine Gowan, Vibha Sharma, Christopher D Raeburn, Maria Albuja-Cruz, Kenneth L Jones, Lauren Fishbein, Rebecca Schweppe, Hilary L Somerset, Todd M Pitts, Stephen Leong, Margaret Wierman
Adrenocortical cancer (ACC) is an orphan malignancy that results in heterogeneous clinical phenotypes and molecular genotypes. There are no curative treatments for this deadly cancer with 35% survival at five years. Our understanding of the underlying pathobiology and our ability to test novel therapeutic targets has been limited due to the lack of preclinical models. Here, we report the establishment of two new ACC cell lines and corresponding patient derived xenograft (PDX) models. CU-ACC1 cell line and PDX were derived from a perinephric metastasis in a patient whose primary tumor secreted aldosterone...
January 25, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29362311/-three-cases-of-advanced-or-recurrent-adrenocortical-carcinoma-patients-treated-with-etoposide-doxorubicin-and-cisplatin-plus-mitotane
#17
Sayuri Sasaki
Adrenocortical carcinoma is a rare cancer with poor clinical outcomes due to its propensity to transform or relapse. Reported here are 3 cases of adrenocortical carcinoma that were treated between January 2007a nd December 2013. Etoposide, doxorubicin, and cisplatin plus mitotane(EDP plus mitotane)were administered as adjuvant therapy to 1 patient, while the other patients received the therapy upon relapse of their cancers following surgery. One patient experienced PR and another 1 experienced SD during the course of their treatment...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29348428/evaluation-of-quantitative-parameters-for-distinguishing-pheochromocytoma-from-other-adrenal-tumors
#18
Youichi Ohno, Masakatsu Sone, Daisuke Taura, Toshinari Yamasaki, Katsutoshi Kojima, Kyoko Honda-Kohmo, Yorihide Fukuda, Koji Matsuo, Toshihito Fujii, Akihiro Yasoda, Osamu Ogawa, Nobuya Inagaki
Adrenal tumors are increasingly found incidentally during imaging examinations. It is important to distinguish pheochromocytomas from other adrenal tumors because of the risk of hypertensive crisis. Although catecholamines and their metabolites are generally used to diagnose pheochromocytoma, false-positive test results are common. An effective screening method to distinguish pheochromocytoma from adrenal incidentalomas is needed. We analyzed 297 consecutive patients with adrenal incidentalomas. Our findings included 162 non-functioning tumors, 47 aldosterone-producing adenomas, 26 metastases, 22 cases of subclinical Cushing's syndrome, 21 pheochromocytomas, 12 cases of Cushing's syndrome, and 7 adrenocortical cancers...
March 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29291482/paraneoplastic-neuromyelitis-optica-spectrum-disorder-a-single-center-cohort-description-with-two-cases-of-histological-validation
#19
Philippe Beauchemin, Raffaele Iorio, Anthony L Traboulsee, Thalia Field, Anna V Tinker, Robert L Carruthers
BACKGROUND: Paraneoplastic syndromes are remote effects of cancer caused by an autoimmune response triggered by tumor cells. Paraneoplastic Neuromyelitis Optica Spectrum Disorders (NMOSD) has been previously described, but the underlying mechanism for these rare cases is not well characterized. This paper presents a newly described case series of paraneoplastic NMOSD, including 2 new histological types of cancer and histological validation. METHODS: The UBC NMO clinic database was surveyed and identified 6 patients with paraneoplastic NMOSD...
February 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29288372/robotic-assisted-laparoscopic-surgery-for-pediatric-tumors-a-bicenter-experience
#20
P Meignan, Q Ballouhey, J Lejeune, K Braik, B Longis, A R Cook, H Lardy, L Fourcade, Aurélien Binet
Mini-invasive surgery is more and more integrated in pediatric surgery. The robotic-assisted surgery brought new advantages from which the patient and the surgeon could benefit compared to laparoscopy. Its use in oncological surgery is still controversial. 12 robotic-assisted tumor resections with the da Vinci Surgical Robot (Intuitive Surgical, Sunnyvale, CA) were attempted in 11 children (mean age 7.65 years; age range 0.75-16.75 years; mean weight 30.3 kg; weight range 8.6-62 kg) in two centers. Mean total operative time was 145 min (range 72-263 min)...
December 29, 2017: Journal of Robotic Surgery
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