keyword
https://read.qxmd.com/read/38534453/personalized-driver-gene-prediction-using-graph-convolutional-networks-with-conditional-random-fields
#1
JOURNAL ARTICLE
Pi-Jing Wei, An-Dong Zhu, Ruifen Cao, Chunhou Zheng
Cancer is a complex and evolutionary disease mainly driven by the accumulation of genetic variations in genes. Identifying cancer driver genes is important. However, most related studies have focused on the population level. Cancer is a disease with high heterogeneity. Thus, the discovery of driver genes at the individual level is becoming more valuable but is a great challenge. Although there have been some computational methods proposed to tackle this challenge, few can cover all patient samples well, and there is still room for performance improvement...
March 14, 2024: Biology
https://read.qxmd.com/read/38532453/current-prospects-of-hereditary-adrenal-tumors-towards-better-clinical-management
#2
REVIEW
Akihiro Ohmoto, Naomi Hayashi, Shunji Takahashi, Arisa Ueki
Adrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL) are two rare types of adrenal gland malignancies. Regarding hereditary tumors, some patients with ACC are associated with with Li-Fraumeni syndrome (LFS), and those with PPGL with multiple endocrine neoplasia type 2. Recent studies have expanded this spectrum to include other types of hereditary tumors, such as Lynch syndrome or familial adenomatous polyposis. Individuals harboring germline TP53 pathogenic variants that cause LFS have heterogeneous phenotypes depending on the respective variant type...
March 26, 2024: Hereditary Cancer in Clinical Practice
https://read.qxmd.com/read/38505747/the-mqrg-score-a-novel-prognostic-tool-for-adrenocortical-carcinoma-patients-based-on-mitochondrial-quality
#3
JOURNAL ARTICLE
Tao Chen, Yifan Wang, Xue Chen, Wenbin Zheng, Weiquan Guo, Qi Liang, Jing Wang, Zhongbiao Chen, Yiwen Zhou, Lijia Xiao
OBJECTIVES: Adrenal tumors are common, but adrenocortical carcinomas (ACCs) are a rare and challenging form of cancer to diagnose and manage.This study aimed to explore the critical role of mitochondrial quality in maintaining cellular function and the implications of the abnormal expression of mitochondrial metabolism-related proteins observed in ACC patients. We focused on identifying the connection between mitochondrial quality and the development of ACC at molecular and genomic levels...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38501000/comprehensive-analysis-of-adgre5-gene-in-human-tumors-clinical-relevance-prognostic-implications-and-potential-for-personalized-immunotherapy
#4
JOURNAL ARTICLE
Xiangjian Zhang, Xinxin Zhang, Qiuhui Yang, Ruokuo Han, Walaa Fadhul, Alisha Sachdeva, Xianbo Zhang
PURPOSE: The Adhesion G protein receptor E5 (ADGRE5) gene is involved in a wide range of biological functions in human tumors; however, its specific molecular mechanism and significance in the analysis of human tumors have not yet been determined. Here, we provide a comprehensive genomic architecture of ADGRE5 in the tumor immune microenvironment and its clinical relevance across a broad range of solid tumors. METHODS: In this study, we used publicly available bioinformatics databases, with a primary focus on The Cancer Genome Atlas (TCGA) database and GTEx data, to conduct a comprehensive analysis of the impact on patient prognosis associated with ADGRE5...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38496902/multidimensional-pan-cancer-analysis-of-hspa5-and-its-validation-in-the-prognostic-value-of-bladder-cancer
#5
JOURNAL ARTICLE
YaXuan Wang, Jinfeng Wang, Yang Liu, XiaoLin Wang, MingHua Ren
Endoplasmic reticulum (ER) stress-related genes are closely related to the occurrence, development, and immunotherapy response of tumors. This study provides a comprehensive assessment of HSPA5 from a pan-cancer perspective using multi-omics data. We analyzed the function of HSPA5 in multiple tumor types using multiple databases. Finally, immunohistochemistry was used to examine the relationship between HSPA5 expression in tissue microarrays from 100 patients with bladder cancer and the prognosis of patients with bladder cancer...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38482443/comprehensive-analysis-of-the-effects-of-the-cuprotosis-associated-gene-slc31a1-on-patient-prognosis-and-tumor-microenvironment-in-human-cancer
#6
JOURNAL ARTICLE
Guiqian Zhang, Ning Wang, Shixun Ma, Pengxian Tao, Hui Cai
BACKGROUND: Solute carrier family 31 (copper transporter), member 1 ( SLC31A1 ) is a key factor in maintaining intracellular copper concentration and an important factor affecting cancer energy metabolism. Therefore, exploring the potential biological function and value of SLC31A1 could provide a new direction for the targeted therapy of tumors. METHODS: This study assessed gene expression levels, survival, clinicopathology, gene mutations, methylation levels, the tumor mutational burden (TMB), microsatellite instability (MSI), and the immune cell infiltration of SLC31A1 in pan-cancer using the Tumor Immune Estimation Resource 2...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38473262/the-efficacy-and-safety-of-immune-checkpoint-inhibitors-in-adrenocortical-carcinoma-a-systematic-review-and-meta-analysis
#7
REVIEW
Obada Ababneh, Alina Ghazou, Mohmmad Alawajneh, Saleh Alhaj Mohammad, Abdullah Bani-Hani, Nasr Alrabadi, Aditya Shreenivas
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of different malignancies. However, their efficacy in advanced adrenocortical carcinoma (ACC) remains uncertain. Thus, we conducted a systematic review and meta-analysis to summarize the efficacy and tolerability of ICIs in patients with advanced ACC. We searched PubMed, Scopus, and CENTRAL for studies that used ICIs in ACC. Studies with more than five patients were included in the meta-analysis of the objective response rate (ORR), disease control rate (DCR), overall survival (OS), progression-free survival (PFS), and grade 3/4 adverse events...
February 23, 2024: Cancers
https://read.qxmd.com/read/38463201/surgical-management-of-metastatic-adrenocortical-carcinoma
#8
JOURNAL ARTICLE
Jesse E Passman, Wajid Amjad, Sara P Ginzberg, Jacqueline M Soegaard Ballester, Caitlin Finn, Heather Wachtel
INTRODUCTION: Adrenocortical carcinoma (ACC) is a notoriously aggressive cancer with a dismal prognosis, especially for patients with metastatic disease. Metastatic ACC is classically a contraindication to operative management. Here, we evaluate the impact of primary tumor resection and metastasectomy on survival in metastatic ACC. METHODS: We performed a retrospective cohort study of patients with metastatic ACC (2010-2019) utilizing the National Cancer Database...
January 2024: World Journal of Surgery
https://read.qxmd.com/read/38455785/adrenocortical-sarcomatoid-carcinoma-revealed-by-an-adrenal-incidentaloma-a-case-report
#9
Samia Bentaleb, Ghita Bourkadi, Hayat Aynaou, Houda Salhi
Sarcomatoid carcinoma of the adrenal gland represents an exceedingly unusual and highly aggressive form of adrenocortical carcinoma. Its diagnosis is challenging because of its dual histological components: epithelial and sarcomatoid. Most patients are diagnosed at a late stage and die within months of diagnosis. We report on a 51-year-old man who had adrenocortical sarcomatoid cancer. It was diagnosed as a unilateral left adrenal incidentaloma discovered on a CT scan carried out for abdominal pain. By means of this case, we will present the clinical, radiological, and histological profile of this tumor...
February 2024: Curēus
https://read.qxmd.com/read/38451242/circulating-cell-free-dna-based-biomarkers-for-prognostication-and-disease-monitoring-in-adrenocortical-carcinoma
#10
JOURNAL ARTICLE
Juliane Lippert, Gabrielle Smith, Silke Appenzeller, Laura-Sophie Landwehr, Alessandro Prete, Sonja Steinhauer, Miriam Asia, Hanna Urlaub, Yasir S Elhassan, Stefan Kircher, Wiebke Arlt, Martin Fassnacht, Barbara Altieri, Cristina L Ronchi
Adrenocortical carcinoma (ACC) is a rare aggressive cancer with heterogeneous behaviour. Disease surveillance relies on frequent imaging, which comes with significant radiation exposure. The aim of the study was to investigate the role of circulating cell-free DNA (ccfDNA)-related biomarkers (BM) for prognostication and monitoring of ACC. We investigated 34 patients with ACC and 23 healthy subjects (HS) as controls. ccfDNA was extracted by commercial kits and ccfDNA concentrations quantified by fluorimeter (BM1)...
March 7, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38425404/comprehensive-analysis-of-the-protein-phosphatase-2a-regulatory-subunit-b56%C3%AE%C2%B5-in-pan-cancer-and-its-role-and-mechanism-in-hepatocellular-carcinoma
#11
JOURNAL ARTICLE
Hong-Mei Wu, Yuan-Yuan Huang, Yu-Qiu Xu, Wei-Lai Xiang, Chang Yang, Ru-Yuan Liu, Di Li, Xue-Feng Guo, Zheng-Bao Zhang, Chun-Hua Bei, Sheng-Kui Tan, Xiao-Nian Zhu
BACKGROUND: B56ε is a regulatory subunit of the serine/threonine protein phosphatase 2A, which is abnormally expressed in tumors and regulates various tumor cell functions. At present, the application of B56ε in pan-cancer lacks a comprehensive analysis, and its role and mechanism in hepatocellular carcinoma (HCC) are still unclear. AIM: To analyze B56ε in pan-cancer, and explore its role and mechanism in HCC. METHODS: The Cancer Genome Atlas, Genotype-Tissue Expression, Gene Expression Profiling Interactive Analysis, and Tumor Immune Estimation Resource databases were used to analyze B56ε expression, prognostic mutations, somatic copy number alterations, and tumor immune characteristics in 33 tumors...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38421176/identification-of-intratumor-bacteria-associated-prognostic-risk-score-in-adrenocortical-carcinoma
#12
JOURNAL ARTICLE
Linyi Tan, Dengwei Zhang, Yong-Xin Li, Yuqing Li, Ting Guo, Yang Sun, Ning Li, Chenchen Feng
UNLABELLED: A landmark study by Poore et al. showed intratumor bacteria (ITBs) playing a critical role in most cancers by reproduction of The Cancer Genome Atlas (TCGA) transcriptome data. A recent study by Salzberg et al. argued that ITBs, being overstated as a methodology by Poore et al., were problematic. We previously reported that ITBs were prognostic in adrenocortical carcinoma (ACC), a highly aggressive rare disease using data by Poore et al., and here, we aimed to answer whether ITBs truly existed and were prognostic in ACC...
February 29, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38415841/-expression-and-prognostic-relevance-of-pd-1-pd-l1-and-ctla-4-immune-checkpoints-in-adrenocortical-carcinoma
#13
JOURNAL ARTICLE
Laura-Sophie Landwehr, Barbara Altieri, Iuliu Sbiera, Hanna Remde, Stefan Kircher, Julie Olabe, Silviu Sbiera, Matthias Kroiss, Martin Fassnacht
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with poor prognosis in advanced stages. While therapies targeting the checkpoint molecules programmed cell death 1 (PD-1), its ligand PD-L1 and the cytotoxic T lymphocyte-associated protein 4 (CTLA-4) have revolutionized treatment in many cancers, the results in ACC were heterogeneous. Their expression in ACC has not been systematically studied and might explain the variable response to checkpoint inhibitors. The expression of PD-1, PD-L1 and CTLA-4 was examined in 162 tumor samples from 122 ACC patients by immunohistochemistry (threshold of >1%) and correlated with tumoral T lymphocyte infiltration and clinical endpoints...
February 28, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38412388/cancer-risks-associated-with-tp53-pathogenic-variants-maximum-likelihood-analysis-of-extended-pedigrees-for-diagnosis-of-first-cancers-beyond-the-li-fraumeni-syndrome-spectrum
#14
MULTICENTER STUDY
Cristina Fortuno, Bing-Jian Feng, Courtney Carroll, Giovanni Innella, Wendy Kohlmann, Conxi Lázaro, Joan Brunet, Lidia Feliubadaló, Silvia Iglesias, Mireia Menéndez, Alex Teulé, Mandy L Ballinger, David M Thomas, Ainsley Campbell, Mike Field, Marion Harris, Judy Kirk, Nicholas Pachter, Nicola Poplawski, Rachel Susman, Kathy Tucker, Mathew Wallis, Rachel Williams, Elisa Cops, David Goldgar, Paul A James, Amanda B Spurdle
PURPOSE: Establishing accurate age-related penetrance figures for the broad range of cancer types that occur in individuals harboring a pathogenic germline variant in the TP53 gene is essential to determine the most effective clinical management strategies. These figures also permit optimal use of cosegregation data for classification of TP53 variants of unknown significance. Penetrance estimation can easily be affected by bias from ascertainment criteria, an issue not commonly addressed by previous studies...
February 2024: JCO Precision Oncology
https://read.qxmd.com/read/38410859/mmp12-is-a-potential-predictive-and-prognostic-biomarker-of-various-cancers-including-lung-adenocarcinoma
#15
JOURNAL ARTICLE
Guo-Sheng Li, Yu-Xing Tang, Wei Zhang, Jian-Di Li, He-Qing Huang, Jun Liu, Zong-Wang Fu, Rong-Quan He, Jin-Liang Kong, Hua-Fu Zhou, Gang Chen
OBJECTIVE: This study sought to explore the clinical value of matrix metalloproteinases 12 ( MMP12 ) in multiple cancers, including lung adenocarcinoma (LUAD). METHODS: Using >10,000 samples, this retrospective study demonstrated the first pan-cancer analysis of MMP12 . The expression of MMP12 between cancer groups and their control groups was analyzed using Wilcoxon rank-sum tests. The clinical significance of MMP12 expression in multiple cancers was assessed using receiver operating characteristic curves, Kaplan-Meier curves, and univariate Cox analysis...
2024: Cancer Control: Journal of the Moffitt Cancer Center
https://read.qxmd.com/read/38398097/the-value-of-local-therapies-in-advanced-adrenocortical-carcinoma
#16
JOURNAL ARTICLE
Otilia Kimpel, Barbara Altieri, Marta Laganà, Thomas J Vogl, Hamzah Adwan, Tina Dusek, Vittoria Basile, James Pittaway, Ulrich Dischinger, Marcus Quinkler, Matthias Kroiss, Soraya Puglisi, Deborah Cosentini, Ralph Kickuth, Darko Kastelan, Martin Fassnacht
International guidelines recommend local therapies (LTs) such as local thermal ablation (LTA; radiofrequency, microwave, cryoablation), transarterial (chemo)embolisation (TA(C)E), and transarterial radioembolisation (TARE) as therapeutic options for advanced adrenocortical carcinoma (ACC). However, the evidence for these recommendations is scarce. We retrospectively analysed patients receiving LTs for advanced ACC. Time to progression of the treated lesion (tTTP) was the primary endpoint. The secondary endpoints were best objective response, overall progression-free survival, overall survival, adverse events, and the establishment of predictive factors by multivariate Cox analyses...
February 7, 2024: Cancers
https://read.qxmd.com/read/38398093/pulmonary-metastasectomy-for-adrenocortical-carcinoma-not-if-but-when
#17
JOURNAL ARTICLE
Shamus R Carr, Frank Villa Hernandez, Diana Grace Varghese, Hyoyoung Choo-Wosoba, Seth M Steinberg, Martha E Teke, Jaydira Del Rivero, David S Schrump, Chuong D Hoang
BACKGROUND: Adrenocortical carcinoma (ACC) commonly metastasizes to the lungs, and pulmonary metastasectomy (PM) is utilized due to limited systemic options. METHODS: All ACC patients with initially only lung metastases (LM) from a single institution constituted this observational case series. Kaplan-Meier and Cox proportional hazard analyses evaluated the association with potential prognostic factors and outcomes. Overall survival (OS) was calculated from the date of the PM or, in those patients who did not undergo surgery, from the development of LM...
February 7, 2024: Cancers
https://read.qxmd.com/read/38381694/adrenocortical-carcinomas-molecular-pathogenesis-treatment-options-and-emerging-immunotherapy-and-targeted-therapy-approaches
#18
JOURNAL ARTICLE
Divya Chukkalore, Kira MacDougall, Viraj Master, Mehmet Asim Bilen, Bassel Nazha
Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy in the advanced setting with poor prognosis. This narrative review provides an overview of the epidemiology of ACC and its molecular pathogenesis with a summary of the main involved signaling pathways. We then provide an update on the clinical presentation, diagnosis, and current management strategies of both localized and metastatic disease from a multidisciplinary perspective. We highlight the debate around the use of mitotane in the adjuvant setting and review the use of combination chemotherapy with etoposide, doxorubicin, and cisplatin...
February 21, 2024: Oncologist
https://read.qxmd.com/read/38366618/surgical-stress-induced-tumor-immune-suppressive-environment
#19
JOURNAL ARTICLE
Fan Yang, Qing Hua, Xiaoyan Zhu, Pingbo Xu
Despite significant advances in cancer treatment over the decades, surgical resection remains a prominent management approach for solid neoplasms. Unfortunately, accumulating evidence suggests that surgical stress caused by tumor resection may potentially trigger postoperative metastatic niche formation. Surgical stress not only activates the sympathetic-adrenomedullary axis and hypothalamic-pituitary-adrenocortical axis but also induces a hypoxia and hypercoagulable state. These adverse factors can negatively impact the immune system by downregulating immune effector cells and upregulating immune suppressor cells, which contribute to the colonization and progression of postoperative tumor metastatic niche...
February 15, 2024: Carcinogenesis
https://read.qxmd.com/read/38363202/multivariable-model-versus-ajcc-staging-system-cancer-specific-survival-predictions-in-adrenocortical-carcinoma
#20
JOURNAL ARTICLE
Letizia Maria Ippolita Jannello, Simone Morra, Lukas Scheipner, Andrea Baudo, Carolin Siech, Mario de Angelis, Nawar Touma, Zhe Tian, Jordan A Goyal, Stefano Luzzago, Francesco Alessandro Mistretta, Mattia Luca Piccinelli, Fred Saad, Felix K H Chun, Alberto Briganti, Sascha Ahyai, Luca Carmignani, Nicola Longo, Ottavio De Cobelli, Gennaro Musi, Pierre I Karakiewicz
We developed a novel contemporary population-based model for predicting cancer-specific survival (CSS) in adrenocortical carcinoma (ACC) patients and compared it with the established 8th edition of the American Joint Committee on Cancer staging system (AJCC). Within the Surveillance, Epidemiology, and End Results database (2004-2020), we identified 1056 ACC patients. Univariable Cox regression model addressed CSS. Harrell's concordance index (c-index) quantified accuracy after 2000 bootstrap resamples for internal validation...
February 1, 2024: Endocrine-related Cancer
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