keyword
https://read.qxmd.com/read/38397467/comprehensive-analysis-of-the-role-of-fibrinogen-and-thrombin-in-clot-formation-and-structure-for-plasma-and-purified-fibrinogen
#21
JOURNAL ARTICLE
Rebecca A Risman, Heather A Belcher, Ranjini K Ramanujam, John W Weisel, Nathan E Hudson, Valerie Tutwiler
Altered properties of fibrin clots have been associated with bleeding and thrombotic disorders, including hemophilia or trauma and heart attack or stroke. Clotting factors, such as thrombin and tissue factor, or blood plasma proteins, such as fibrinogen, play critical roles in fibrin network polymerization. The concentrations and combinations of these proteins affect the structure and stability of clots, which can lead to downstream complications. The present work includes clots made from plasma and purified fibrinogen and shows how varying fibrinogen and activation factor concentrations affect the fibrin properties under both conditions...
February 16, 2024: Biomolecules
https://read.qxmd.com/read/38397016/the-role-of-the-kinin-system-and-the-effect-of-des-arginine-9-bradykinin-on-coagulation-and-platelet-function-in-critically-ill-covid-19-patients-a-secondary-analysis-of-a-prospective-observational-study
#22
JOURNAL ARTICLE
Fabian Edinger, Sophia Edinger, Götz Schmidt, Christian Koch, Michael Sander, Emmanuel Schneck
The effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the coagulation system is not fully understood. SARS-CoV-2 penetrates cells through angiotensin-converting enzyme 2 (ACE2) receptors, leading to its downregulation. Des-arginine9 -bradykinin (DA9B) is degraded by ACE2 and causes vasodilation and increased vascular permeability. Furthermore, DA9B is associated with impaired platelet function. Therefore, the aim of this study was to evaluate the effects of DA9B on platelet function and coagulopathy in critically ill coronavirus disease 2019 (COVID-19) patients...
February 16, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38390985/massive-transfusion-in-trauma
#23
JOURNAL ARTICLE
Heiko Lier, Björn Hossfeld
PURPOSE OF REVIEW: The purpose of this review is to provide an overview of currently recommended treatment approaches for traumatic hemorrhage shock, with a special focus on massive transfusion. RECENT FINDINGS: Severe trauma patients require massive transfusion, but consensual international definitions for traumatic hemorrhage shock and massive transfusion are missing. Current literature defines a massive transfusion as transfusion of a minimum of 3-4 packed red blood cells within 1 h...
January 22, 2024: Current Opinion in Anaesthesiology
https://read.qxmd.com/read/38387004/unresponsiveness-of-activated-partial-thromboplastin-time-to-bivalirudin-in-adults-receiving-extracorporeal-membrane-oxygenation
#24
JOURNAL ARTICLE
Andrew J Jatis, Scott D Nei, Troy G Seelhammer, Kristin C Mara, Patrick M Wieruszewski
Activated partial thromboplastin time (aPTT) is the standard for monitoring bivalirudin but demonstrates a nonlinear response at higher drug concentrations. The objective of this study was to assess the relationship between bivalirudin dose and aPTT in patients receiving extracorporeal membrane oxygenation (ECMO) to determine a threshold where aPTT unresponsiveness occurs. Two hundred fourteen adults receiving bivalirudin during ECMO between 2018 and 2022 were included. Piecewise regression in a linear mixed effects model was used to determine a bivalirudin dose threshold of 0...
February 22, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/38382192/evaluation-of-viscoelastic-coagulation-monitoring-parameters-and-fibrinogen-concentrations-in-healthy-dogs-undergoing-stifle-arthroscopy-and-tibial-plateau-leveling-osteotomy
#25
JOURNAL ARTICLE
Mackenzie Grace, Rebecca Salazar, Jose Zayas, Philip Allen
OBJECTIVE: Evaluation of viscoelastic parameters along with Hct percentages, platelet numbers, and fibrinogen concentrations in healthy dogs undergoing elective stifle arthroscopy and tibial plateau leveling osteotomy (TPLO). These results determine if dogs are in a normal, hypocoagulable, or hypercoagulable state at 4 different time points. ANIMALS: Prospective study of 37 client-owned dogs enrolled between February 2, 2022, and November 10, 2022. METHODS: All dogs received a standardized anesthetic protocol...
February 12, 2024: American Journal of Veterinary Research
https://read.qxmd.com/read/38381480/coarse-particulate-matter-and-markers-of-inflammation-and-coagulation-in-the-multi-ethnic-study-of-atherosclerosis-mesa-population-a-repeat-measures-analysis
#26
JOURNAL ARTICLE
Meredith Pedde, Timothy V Larson, Jennifer D'Souza, Adam A Szpiro, Itai Kloog, Lynda D Lisabeth, David Jacobs, Lianne Sheppard, Matthew Allison, Joel D Kaufman, Sara D Adar
BACKGROUND: In contrast to fine particles, less is known of the inflammatory and coagulation impacts of coarse particulate matter (<mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mrow><mml:mi>PM</mml:mi></mml:mrow></mml:mrow><mml:mrow><mml:mrow><mml:mn>10</mml:mn><mml:mo>-</mml:mo><mml:mn>2.5</mml:mn></mml:mrow></mml:mrow></mml:msub></mml:mrow></mml:mrow></mml:math>, particulate matter with aerodynamic diameter <mml:math xmlns:mml="https://www...
February 2024: Environmental Health Perspectives
https://read.qxmd.com/read/38379712/validation-of-a-fibrinogen-%C3%AE-enzyme-linked-immunosorbent-assay-using-a-new-monoclonal-antibody-effects-of-bariatric-surgery
#27
JOURNAL ARTICLE
Nadja Bødker Pedersen, Else-Marie Bladbjerg, Claus Bogh Juhl, Anette Larsen, Anna-Marie Bloch Münster, Moniek P M de Maat, Yaseelan Palarasah
BACKGROUND: Fibrinogen γ' is a naturally occurring 20-amino-acid splice variant of the fibrinogen γ chain. Animal studies link variations in fibrinogen to obesity, but it is unknown how fibrinogen γ' is associated with obesity in humans. OBJECTIVES: To develop and validate an enzyme-linked immunosorbent assay (ELISA) for fibrinogen γ' quantification in human plasma and analyze fibrinogen γ' before and after bariatric surgery. METHODS: We generated C-terminal fibrinogen γ' specific mouse monoclonal antibodies and developed a γ' ELISA...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38379711/contractility-defects-hinder-glycoprotein-vi-mediated-platelet-activation-and-affect-platelet-functions-beyond-clot-contraction
#28
JOURNAL ARTICLE
Martin Kenny, Alice Y Pollitt, Smita Patil, Dishon W Hiebner, Albert Smolenski, Natalija Lakic, Robert Fisher, Reema Alsufyani, Sebastian Lickert, Viola Vogel, Ingmar Schoen
BACKGROUND: Active and passive biomechanical properties of platelets contribute substantially to thrombus formation. Actomyosin contractility drives clot contraction required for stabilizing the hemostatic plug. Impaired contractility results in bleeding but is difficult to detect using platelet function tests. OBJECTIVES: To determine how diminished myosin activity affects platelet functions, including and beyond clot contraction. METHODS: Using the myosin IIA-specific pharmacologic inhibitor blebbistatin, we modulated myosin activity in platelets from healthy donors and systematically characterized platelet responses at various levels of inhibition by interrogating distinct platelet functions at each stage of thrombus formation using a range of complementary assays...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38379394/biomarkers-associated-with-cardiovascular-disease-in-women-with-spontaneous-preterm-birth-a-case-control-study
#29
JOURNAL ARTICLE
Elin Täufer Cederlöf, Susanne Lager, Anders Larsson, Inger Sundström Poromaa, Bertil Lindahl, Anna-Karin Wikström, Christina Christersson
INTRODUCTION: Women with spontaneous preterm birth have an increased risk of cardiovascular disease later in life. Studies suggest potential pathophysiological mechanisms in common, but whether these could be identified by measurement of soluble circulating protein biomarkers in women with spontaneous preterm birth is unknown. The aim of this study was to determine if protein biomarkers associated with cardiovascular disease distinguish women with spontaneous preterm birth from healthy controls, both at pregnancy and at follow up...
February 20, 2024: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/38372154/point-of-care-and-traditional-erythrocyte-sedimentation-rate-point-of-care-rheometry-and-cell-free-dna-concentration-in-dogs-with-or-without-systemic-inflammation
#30
JOURNAL ARTICLE
Rachel C Clarkin-Breslin, Benjamin M Brainard
RBC aggregation and deformability characteristics are altered by inflammatory, microcirculatory, and hemorheologic disease. These changes can be indirectly evaluated using the erythrocyte sedimentation rate (ESR). Newer point-of-care devices employ syllectometry to evaluate RBC rheology, which can give information beyond the ESR. We evaluated 2 point-of-care rheometers (iSED and MIZAR; Alcor Scientific) in 52 dogs presented to a university teaching hospital. Whole blood samples were analyzed for correlation between the ESR using the Westergren (ESRw) method (measured at 1 h and 24 h) and the predicted ESR using iSED...
February 19, 2024: Journal of Veterinary Diagnostic Investigation
https://read.qxmd.com/read/38367449/in-silico-study-of-combination-thrombolytic-therapy-with-alteplase-and-mutant-pro-urokinase-for-fibrinolysis-in-ischemic-stroke
#31
JOURNAL ARTICLE
Yilin Yang, Boram Gu, Xiao Yun Xu
The synergistic advantage of combining tissue plasminogen activator (tPA) with pro-urokinase (proUK) for thrombolysis has been demonstrated in several in vitro experiments, and a single site proUK mutant (m-proUK) has been developed for better stability in plasma. Based on these studies, combination thrombolytic therapy with intravenous tPA and m-proUK has been suggested as a promising treatment for patients with ischemic stroke. This paper evaluates the efficacy and safety of the dual therapy by computational simulations of pharmacokinetics and pharmacodynamics coupled with a local fibrinolysis model...
February 13, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38363248/proteomics-of-serum-derived-extracellular-vesicles-are-associated-with-the-severity-and-different-clinical-profiles-of-patients-with-covid-19-an-exploratory-secondary-analysis
#32
JOURNAL ARTICLE
Adriana F Paes Leme, Sami Yokoo, Ana Gabriela C Normando, João Vitor S Ormonde, Romenia Ramos Domingues, Fernanda F Cruz, Pedro L Silva, Bruno S F Souza, Claudia C Dos Santos, Hugo Castro-Faria-Neto, Camila Marinelli Martins, Miquéias Lopes-Pacheco, Patricia R M Rocco
BACKGROUND AIMS: Coronavirus disease 2019 (COVID-19) is characterized by a broad spectrum of clinical manifestations with the potential to progress to multiple organ dysfunction in severe cases. Extracellular vesicles (EVs) carry a range of biological cargoes, which may be used as biomarkers of disease state. METHODS: An exploratory secondary analysis of the SARITA-2 and SARITA-1 datasets (randomized clinical trials on patients with mild and moderate/severe COVID-19) was performed...
February 15, 2024: Cytotherapy
https://read.qxmd.com/read/38363086/on-the-mechanism-of-self-assembly-of-fibrinogen-in-thrombin-free-aqueous-solution
#33
JOURNAL ARTICLE
Sanjib Saha, Anne Büngeler, Dominik Hense, Oliver I Strube, Klaus Huber
Fibrinogen dissolved in 0.12 M aqueous NaCl solution at a pH of 6.6 exhibits self-assembly in response to a lowering of the NaCl concentration to values equal to or lower than 60 mM. As has been established in a preceding work (Langmuir 2019, 35, and 12113), a characteristic signature of the self-assembly triggered by a drop in ionic strength is the formation of large globular particles. Growth of these particles most likely obeys a coalescence-like process also termed a step growth process. In order to extend this knowledge, the present work first optimized the protocol, leading to highly reproducible self-assembly experiments...
February 16, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
https://read.qxmd.com/read/38357407/comparison-of-blood-concentration-and-weight-based-heparin-and-protamine-dosing-strategies-for-cardiopulmonary-bypass-a-systematic-review-and-meta-analysis
#34
REVIEW
Gavin Raner, Yirui Hu, Cody Trowbridge, Li Zhang, John Logan, Xianren Wu, Xiaopeng Zhang
BACKGROUND:  The conventional method of heparin and protamine management during cardiopulmonary bypass (CPB) is based on total body weight which fails to account for the heterogeneous response to heparin in each patient. On the other hand, the literature is inconclusive on whether individualized anticoagulation management based on real-time blood heparin concentration improves post-CBP outcomes. METHODS:  We searched databases of Medline, Excerpta Medica dataBASE (EMBASE), PubMed, Cumulative Index to Nursing and Allied Health Literature (CINHL), and Google Scholar, recruiting randomized controlled trials (RCTs) and prospective studies comparing the outcomes of dosing heparin and/or protamine based on measured heparin concentration versus patient's total body weight for CPB...
February 2024: Curēus
https://read.qxmd.com/read/38348024/an-early-warning-indicator-of-mortality-risk-in-patients-with-covid-19-the-neutrophil-extracellular-traps-neutrophilic-segmented-granulocyte-ratio
#35
JOURNAL ARTICLE
Qiong Wang, Yu Qin, Jingyun Ma, Kehao Zhou, Guiping Xia, Ya Li, Li Xie, Richmond Godwin Afful, Qian Lan, Xingyu Huo, Jian Zou, Hailin Yang
BACKGROUND: Neutrophil extracellular traps (NETs) play a key role in thrombus formation in patients with coronavirus disease 2019 (COVID-19). However, the existing detection and observation methods for NETs are limited in their ability to provide quantitative, convenient, and accurate descriptions of in situ NETs. Therefore, establishing a quantitative description of the relationship between NETs and thrombosis remains a challenge. OBJECTIVE: We employed morphological observations of blood cells and statistical analyses to investigate the correlation between the NETs/neutrophilic segmented granulocyte ratio and mortality risk in patients with COVID-19...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38345186/platelet-vesicles-synergetic-with-biosynthetic-cellulose-aerogels-for-ultra-fast-hemostasis-and-wound-healing
#36
JOURNAL ARTICLE
Ying Wang, Yicheng Guo, Yuqing Liu, Xiaohong Zhao, Yong Huang, Xiaorong Zhang, Xiaohong Hu, Kibret Mequanint, Gaoxing Luo, Malcolm Xing
Achieving hemostasis in penetrating and irregular wounds is challenging because the hemostasis factor cannot arrive at the bleeding site, and substantial bleeding will wash away the blood clot. Since the inherently gradual nature of blood clot formation takes time, a physical barrier is needed before blood clot formation. Herein, we report an ultra-light and shape memory hemostatic aerogel consisting of oxidized bacterial cellulose (OBC) and platelet extracellular vesicles (pVEs). The OBC-pVEs aerogel provides a physical barrier for the bleeding site by self-expansion, absorbing the liquid from blood to concentrate platelets and clotting factors and accelerating the clot formation by activating platelets and transforming fibrinogen into fibrin...
February 12, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38341558/subcutaneous-application-of-hyperimmune-serum-against-histophilus-somni-recombinant-proteins-affects-serum-antibody-reactivity-in-beef-calves
#37
JOURNAL ARTICLE
Bajzert Joanna, Jawor Paulina, Baran Rafał, Stefaniak Tadeusz
BACKGROUND: Respiratory tract diseases cause significant economic loss in beef cattle. This study aimed to determine whether the application of hyperimmune serum (HS) containing antibodies against selected antigens of Gram-negative bacteria would improve the health and growth of different breeds of beef calves kept on three farms. Two recombinant protein antigens (Histophilus somni rHsp60 and rOMP40) were used to immunize four cows to produce HS. Eighty seven beef calves (Charolaise n = 36, Limousine n = 34, and crossbreed n = 17) were included into study...
February 10, 2024: BMC Veterinary Research
https://read.qxmd.com/read/38340536/immunophenotyping-of-peripheral-circulating-lymphocytes-and-serum-selenium-levels-in-calves-with-neonatal-diarrhea
#38
JOURNAL ARTICLE
Murat Uztimür, Ömer Kizil, Hatice Handan Akbulut
This work aims to: (1) elucidate the immune response exhibited by CD4 + and CD8 + T lymphocyte cells in response to various infectious agents in calves suffering with neonatal diarrhea; and (2) determine and investigate the association between serum selenium levels and T lymphocyte subtypes in neonatal calves afflicted with neonatal diarrhea and infected with various infectious agents. The study encompassed a cohort of 50 calves, encompassing both sexes and various breeds, within the neonatal age range (1-28 days old)...
February 6, 2024: Veterinary Immunology and Immunopathology
https://read.qxmd.com/read/38337715/is-the-habitual-dietary-intake-of-foods-of-plant-or-animal-origin-associated-with-circulating-hemostatic-factors-results-of-the-population-based-kora-fit-study
#39
JOURNAL ARTICLE
Michael Schepp, Dennis Freuer, Annette Peters, Margit Heier, Daniel Teupser, Christine Meisinger, Jakob Linseisen
Blood coagulation is a complex physiological process critical for maintaining hemostasis, and disruptions in this system can lead to various health complications. Since the effects of specific food groups on a series of circulating coagulation parameters in the population are not well established, this study examines such associations in the population-based KORA-Fit study. A total of 595 subjects (263 men and 332 women) born between 1945 and 1964 and living in the study region of Augsburg were included in the study...
January 31, 2024: Nutrients
https://read.qxmd.com/read/38334914/age-related-variation-in-coagulation-factors-in-non-valvular-atrial-fibrillation-patients-receiving-direct-oral-anticoagulants
#40
JOURNAL ARTICLE
Osamu Kumano, Shinya Suzuki, Masako Yamazaki, Yoshimori An, Masahiro Yasaka, Masahiro Ieko
Age is a significant risk factor for ischemic stroke. However, the influence of aging on coagulation parameters in non-valvular atrial fibrillation (NVAF) patients treated with direct oral anticoagulants (DOACs) remains unclear. A total of 775 samples were collected from 224 NVAF patients receiving apixaban, edoxaban or rivaroxaban. The samples were categorized into three age groups: (i) ≤ 64 years, (ii) 65-74 years, and (iii) ≥ 75 years (apixaban: N = 48, 108, 119; edoxaban: N = 63, 68, 126; rivaroxaban: N = 115, 90, 38, respectively)...
February 9, 2024: International Journal of Hematology
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