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Fibrinogen Concentrate

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https://www.readbyqxmd.com/read/28641369/markers-of-inflammation-and-incident-breast-cancer-risk-in-the-women-s-health-study
#1
Deirdre K Tobias, Akintunde O Akinkuolie, Paulette D Chandler, Patrick R Lawler, JoAnn E Manson, Julie E Buring, Paul M Ridker, Lu Wang, I-Min Lee, Samia Mora
Chronic inflammation may be a risk factor for breast cancer development and progression, yet which inflammatory biomarkers and pathways are relevant is unknown. The study included 27,071 Women's Health Study participants (mean, 54.5 years old) free of cancer and cardiovascular disease at enrollment (1992 to 1995) with baseline measures of four inflammatory biomarkers: high sensitivity C-reactive protein (hsCRP), fibrinogen, N-acetyl side-chains of acute phase proteins (GlycA), and soluble intercellular adhesion molecule-1 (sICAM-1)...
June 21, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28632435/relative-effects-of-plasma-fibrinogen-concentrate-and-factor-xiii-on-rotem-coagulation-profiles-in-an-in-vitro-model-of-massive-transfusion-in-trauma
#2
David E Schmidt, Märit Halmin, Agneta Wikman, Anders Östlund, Anna Ågren
Massive traumatic haemorrhage is aggravated through the development of trauma-induced coagulopathy, which is managed by plasma transfusion and/or fibrinogen concentrate administration. It is yet unclear whether these treatments are equally potent in ensuring adequate haemostasis, and whether additional factor XIII (FXIII) administration provides further benefits. In this study, we compared ROTEM whole blood coagulation profiles after experimental massive transfusion with different transfusion regimens in an in vitro model of dilution- and transfusion-related coagulopathy...
June 20, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28629414/fibrinogen-deficiency-in-a-dog-a-case-report
#3
Franck Jolivet, Armelle Diquélou, Catherine Trumel, Simon Privat, Olivier Dossin
BACKGROUND: Among coagulation disorders, primary fibrinogen deficiency is very rare in dogs. It is divided into hypofibrinogenemia, afibrinogenemia and dysfibrinogenemia. Afibrinogenemia has been described in three dogs. There are, however, no published case reports of primary hypofibrinogenemia in dogs. CASE PRESENTATION: A 1.5 year-old male German Pointer dog was evaluated for a locked-jaw syndrome associated with eye protrusion which appeared after a minor head trauma...
June 19, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28629364/changes-in-concentrations-of-haemostatic-and-inflammatory-biomarkers-in-synovial-fluid-after-intra-articular-injection-of-lipopolysaccharide-in-horses
#4
Stine Mandrup Andreassen, Anne Mette Lindberg Vinther, Søren Saxmose Nielsen, Pia Haubro Andersen, Aziz Tnibar, Annemarie T Kristensen, Stine Jacobsen
BACKGROUND: Septic arthritis is a common and potentially devastating disease characterized by severe intra-articular (IA) inflammation and fibrin deposition. Research into equine joint pathologies has focused on inflammation, but recent research in humans suggests that both haemostatic and inflammatory pathways are activated in the joint compartment in arthritic conditions. The aim of this study was to characterize the IA haemostatic and inflammatory responses in horses with experimental lipopolysaccharide (LPS)-induced joint inflammation...
June 19, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28621285/assessment-of-c-reactive-proteins-cytokines-and-plasma-protein-levels-in-hypertensive-patients-with-apical-periodontitis
#5
N Rashmi, Vineet Galhotra, Pallavi Goel, Jagadish P Rajguru, Satyendra K Jha, Kiran Kulkarni
INTRODUCTION: Chronic apical periodontitis (CAP) manifests mostly as periapical radiolucency. Various inflammatory mediators play a significant role in the pathogenesis of apical periodontitis. In acute inflammatory conditions, C-reactive proteins (CRP) and fibrinogen show a rise in their concentrations. In chronic diseases with high inflammatory components, an increased prevalence of hypertension has been observed. Hence, we assessed the association of CAP and plasma levels of various inflammatory markers (CRP, interleukin 6 [IL-6], and fibrinogen) in severely hypertensive patients...
June 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28620476/vitamin-d-and-inflammatory-markers-cross-sectional-analyses-using-data-from-the-english-longitudinal-study-of-ageing-elsa
#6
Cesar de Oliveira, Jane P Biddulph, Vasant Hirani, Ione Jayce Ceola Schneider
Recent evidence suggests that low vitamin D concentrations are associated with increased levels of inflammatory markers. However, there are limited studies investigating associations between vitamin D levels and inflammatory markers in the general population and much of this evidence in older adults is inconclusive. Therefore, this study investigates the cross-sectional association of serum 25-hydroxyvitamin D (25(OH)D) levels with inflammatory markers in 5870 older English adults from wave 6 (2012-2013) of the English Longitudinal Study of Ageing (ELSA)...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/28616954/surface-charge-and-particle-size-determine-the-metabolic-fate-of-dendritic-polyglycerols
#7
Kritee Pant, Johanna Pufe, Kristof Zarschler, Ralf Bergmann, Jörg Steinbach, Sabine Reimann, Rainer Haag, Jens Pietzsch, Holger Stephan
Dendritic polyglycerols (dPG) are water soluble, polyether-based nanomaterials which hold great potential in diagnostic as well as therapeutic applications. In order to translate them for in vivo applications, a systematic assessment regarding their cell and tissue interactions as well as their metabolic fate in vivo is a crucial step. Herein, we explore the structure-activity relationship of three different sizes (ca. 3, 5, and 10 nm) of neutral dendritic polyglycerol (dPG) and their corresponding negatively charged sulfate analogs (dPGS) on their in vitro and in vivo characteristics...
June 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/28614772/inhibition-of-blood-platelet-adhesion-by-phenolics-rich-fraction-of-hippophae-rhamnoides-l-fruits
#8
B Olas, B Kontek, M Szczesna, L Grabarczyk, A Stochmal, J Zuchowski
Beneficial influence of fruits on human health may be their ability to prevent the hyperactivation of blood platelets and cardiovascular disorders. Effects of the phenolic fraction from Hippophae rhamnoides fruit on different stages of blood platelet activation (platelet adhesion and aggregation) were studied in vitro. We also examined effects of the H. rhamnoides fraction on metabolism of thiol groups, which plays an important role in platelet functions. The effects of the H. rhamnoides fraction on adhesion of blood platelets to collagen and fibrinogen were determined with Tuszynski's and Murphy's method...
April 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28601829/serum-fibrinogen-and-cardiovascular-events-in-chinese-patients-with-type-2-diabetes-and-stable-coronary-artery-disease-a-prospective-observational-study
#9
Sheng-Hua Yang, Ying Du, Yan Zhang, Xiao-Lin Li, Sha Li, Rui-Xia Xu, Cheng-Gang Zhu, Yuan-Lin Guo, Na-Qiong Wu, Ping Qing, Ying Gao, Chuan-Jue Cui, Qian Dong, Jing Sun, Jian-Jun Li
OBJECTIVES: The aim of this study was to investigate the association of serum fibrinogen with cardiovascular events (CVE) in Chinese patients with type 2 diabetes mellitus (T2DM) and stable coronary artery disease (CAD). DESIGN: An observational study. SETTING: FuWai Hospital in Beijing, China. PARTICIPANTS: A cohort of 1466 patients with T2DM and angiographic-proven stable CAD was evaluated. OUTCOME MEASURES: Baseline serum fibrinogen levels were measured and trisected into 'low', 'middle' and 'high'...
June 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28599038/albumin-for-prehospital-fluid-resuscitation-of-hemorrhagic-shock-in-tactical-combat-casualty-care
#10
Nicholas M Studer, Michael D April, F Bowling, Paul D Danielson, Andrew P Cap
Optimal fluid resuscitation on the battlefield in the absence of blood products remains unclear. Contemporary Combat medics are generally limited to hydroxyethyl starch or crystalloid solutions, both of which present significant drawbacks. Obtaining US Food and Drug Administration (FDA)-approved freeze-dried plasma (FDP) is a top casualty care research priority for the US Military. Interest in this agent reflects a desire to simultaneously expand intravascular volume and address coagulopathy. The history of FDP dates to the Second World War, when American expeditionary forces used this agent frequently...
2017: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28598833/changes-of-red-blood-cell-aggregation-parameters-in-a-long-term-follow-up-of-splenectomy-spleen-autotransplantation-and-partial-or-subtotal-spleen-resections-in-a-canine-model
#11
Iren Miko, Norbert Nemeth, Katalin Peto, Andrea Furka, Laszlo Toth, Istvan Furka
BACKGROUND: Decrease or loss in splenic filtration function may influence the hemorheological state. OBJECTIVE: To follow-up the long-term effects of splenectomy, spleen autotransplantation and spleen resections on red blood cell aggregation in a canine model. METHODS: Beagle dogs were subjected to control (n = 6), splenectomy (SE, n = 4), spleen autotransplantation (AU, Furka's spleen-chip method, n = 8) or partial and subtotal spleen resection (n = 4/each) groups, and followed-up for 18 postoperative (p...
June 7, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28598242/antithrombotic-effect-of-fermented-ophiopogon-japonicus-in-thrombosis-induced-rat-models
#12
Yi-Lin Zhang, Mei-Zhu Xi, Young-Bin Choi, Bog-Hieu Lee
In this study, the antithrombotic and thrombolytic ability of second fermented extract of Ophiopogon japonicus (FEOJ) was verified in thrombosis-induced rats. Thrombosis was induced by oral administration of 2% carrageenan for 4 weeks. Five experimental groups (n = 9/group) involved in the study were control group, thrombosis group, low-dose FEOJ group (2 mL/kg, low-dose Ophiopogon japonicus [LOJ]), middle-dose FEOJ group (6 mL/kg, medium-dose Ophiopogon japonicus [MOJ]), and high-dose FEOJ group (12 mL/kg, high-dose Ophiopogon japonicus [HOJ])...
June 9, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28597461/serum-concentration-of-growth-differentiation-factor-15-is-independently-associated-with-global-platelet-function-and-higher-fibrinogen-values-in-adult-healthy-subjects
#13
Giuseppe Lippi, Gian Luca Salvagno, Elisa Danese, Giorgio Brocco, Matteo Gelati, Martina Montagnana, Fabian Sanchis-Gomar, Emmanuel J Favaloro
No abstract text is available yet for this article.
June 8, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/28583609/global-hemostasis-in-healthy-bitches-during-pregnancy-and-at-different-estrous-cycle-stages-evaluation-of-routine-hemostatic-tests-and-thromboelastometry
#14
Sigal Klainbart, Alexandra Slon, Efrat Kelmer, Tali Bdolah-Abram, Tal Raz, Gilad Segev, Itamar Aroch, Smadar Tal
This study assessed the global hemostasis (including prothrombin time [PT], activated partial thromboplastin time [aPTT], antithrombin activity [ATA], fibrinogen and d-Dimer concentrations, platelet count, plateletcrit and thromboelastometry) in healthy pregnant bitches, comparing the results with those of healthy bitches at different estrous cycle stages, and assessed whether hemostatic changes during pregnancy are associated with serum progesterone concentration or the presence of fetuses in utero. The results show that pregnant bitches have higher fibrinogen concentration, platelet count and platelatecrit, and that fibrin and global clot formations occur faster than in non-pregnant bitches at different estrous cycle stages...
July 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28580507/retrospective-evaluation-of-thromboembolism-risk-in-ovarian-cancer-patients-treated-with-bevacizumab
#15
Anna Kuk, Magdalena Magnowska, Wiktor Suchy, Joanna Swierczynska, Mikolaj Piotr Zaborowski, Michal Gaca, Ewa Nowak-Markwitz
BACKGROUND: Bevacizumab is used in addition to standard, platinum-based chemotherapy to treat advanced-stage ovarian cancer patients. Thrombosis is a well-documented adverse effect of bevacizumab. OBJECTIVE: The aim of this study was to identify predictive parameters for thromboembolic events in ovarian cancer patients and to explain how bevacizumab increases the risk of these events. PATIENTS AND METHODS: Fifty-seven FIGO stage III ovarian cancer patients who underwent cytoreductive surgery and chemotherapy were identified and included in this retrospective study...
June 4, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28554712/the-role-of-cr3-cd11b-cd18-and-cr4-cd11c-cd18-in-complement-mediated-phagocytosis-and-podosome-formation-by-human-phagocytes
#16
Szilvia Lukácsi, Zsuzsa Nagy-Baló, Anna Erdei, Noémi Sándor, Zsuzsa Bajtay
CR3 and CR4 belong to the family of β2-integrins and play an important role in phagocytosis, cellular adherence and migration. CR3 and CR4 are generally expected to mediate similar functions due to their structural homology, overlapping ligand specificity and parallel expression on human phagocytes. Although the different signalling pathways of these receptors suggest distinct functions, possible differences are just being revealed. Previously we proved that CR3 plays a key role in the uptake of iC3b-opsonized particles by human dendritic cells...
May 26, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28553109/bitistatin-functionalized-fluorescent-nanodiamond-particles-specifically-bind-to-purified-human-platelet-integrin-receptor-%C3%AE-iib%C3%AE-3-and-activated-platelets
#17
Cezary Marcinkiewicz, Jonathan A Gerstenhaber, Mark Sternberg, Peter I Lelkes, Giora Feuerstein
Thromboembolic events (TEE) underwrite key causes of death in developed countries. While advanced imaging technologies such as computed tomography scans serve to diagnose blood clots during acute cardiovascular events, no such technology is available in routine primary care for TEE risk assessment. Here, we describe an imaging platform technology based on bioengineered fluorescent nanodiamond particles (F-NDPs) functionalized with bitistatin (Bit), a disintegrin that specifically binds to the αIIbβ3 integrin, platelet fibrinogen receptor (PFR) on activated platelets...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28549445/fibrinogen-early-in-severe-trauma-study-feisty-study-protocol-for-a-randomised-controlled-trial
#18
James Winearls, Martin Wullschleger, Elizabeth Wake, Catherine Hurn, Jeremy Furyk, Glenn Ryan, Melita Trout, James Walsham, Anthony Holley, Jeremy Cohen, Megan Shuttleworth, Wayne Dyer, Gerben Keijzers, John F Fraser, Jeffrey Presneill, Don Campbell
BACKGROUND: Haemorrhage is a leading cause of death in severe trauma. Fibrinogen plays a critical role in maintaining haemostasis in traumatic haemorrhage. Early fibrinogen replacement is recommended by several international trauma guidelines using either fibrinogen concentrate (FC) or cryoprecipitate (Cryo). There is limited evidence to support one product over the other with widespread geographic and institutional variation in practice. This pilot trial is the first randomised controlled trial comparing FC to Cryo in traumatic haemorrhage...
May 26, 2017: Trials
https://www.readbyqxmd.com/read/28505046/south-asians-why-are-they-at-a-higher-risk-for-cardiovascular-disease
#19
Anjly Jain, Rajeev Puri, Devaki R Nair
PURPOSE OF REVIEW: We comment on the high prevalence of cardiovascular disease (CVD) in South Asians (SA). The effect of various risk factors, for example biochemical, genetic, lifestyle, socioeconomic factors and psychosocial stress on CVD risk is discussed. RECENT FINDINGS: 'Prediabetes' is common in SA, but its relationship with coronary artery disease (CAD) is not significant unlike for the white population. At the same time, 'prediabetes' in SA is associated with an increased risk for cerebrovascular disease (CeVD)...
July 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28503124/factor-xiii-deficiency-and-thrombocytopenia-are-frequent-modulators-of-postoperative-clot-firmness-in-a-surgical-intensive-care-unit
#20
Sarah von Rappard, Corina Hinnen, Roger Lussmann, Manuela Rechsteiner, Wolfgang Korte
OBJECTIVE: Fibrinogen and factor XIII (FXIII) have been shown to critically influence clot firmness in the intraoperative setting and thus likely influence intraoperative bleeding. We were interested to identify potential modulators of postoperative clot firmness in a tertiary care hospital surgical intensive care unit setting, independent of their clinical course during surgery. METHODS: 272 day-shift consecutive patients were evaluated for whole blood clot firmness evaluated by the ROTEM® EXTEM thrombelastometric assay and various potential modulators of clot firmness upon arrival at the surgical intensive care unit (SICU)...
April 2017: Transfusion Medicine and Hemotherapy
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