keyword
MENU ▼
Read by QxMD icon Read
search

Fibrinogen Concentrate

keyword
https://www.readbyqxmd.com/read/28095333/effect-of-resveratrol-on-platelet-aggregation-by-fibrinogen-protection
#1
Claudia Bonechi, Stefania Lamponi, Alessandro Donati, Gabriella Tamasi, Marco Consumi, Gemma Leone, Claudio Rossi, Agnese Magnani
The effect of resveratrol (RSV) in inhibiting platelet adhesion and aggregation, as well as fibrinogen (FBG) conformational changes promoted by epinephrine (EP), were studied, by using complementary experimental techniques. NMR and IR spectroscopies were used to investigate possible protective effects by RSV towards FBG, in presence of EP. The protective effect of RSV towards FBG was highlighted by spin nuclear relaxation experiments that were interpreted for determining the thermodynamic equilibrium constants of FBG-EP interaction, and by infrared measurements, that showed EP-induced conformational changes of FBG...
January 2, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28081351/the-effect-of-methylprednisolone-treatment-on-fibrinolysis-thecoagulation-system-and-blood-loss-in-cardiac-surgery
#2
Leila Ebrahimi, Maryam Kheirandish, Mahnoosh Foroughi
BACKGROUND/AIM: The purpose of this study was to examine steroid pretreatment in order to decrease postoperative coagulopathy disorders and bleeding. MATERIALS AND METHODS: In this randomized double-blinded study, the efficacy of low versus high doses of methylprednisolone on the coagulation system and postoperative bleeding was compared in patients who were undergoing cardiac surgery with cardiopulmonary bypass (CPB). The platelet response to agonists, D-dimer concentration, tissue plasminogen activator (tPA), plasminogen activator inhibitor (PAI-1) antigens, and platelet receptors CD42b, CD62P, and CD41a were evaluated...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28079258/combined-effect-of-therapeutic-strategies-for-bleeding-injury-on-early-survival-transfusion-needs-and-correction-of-coagulopathy
#3
K Balvers, S van Dieren, K Baksaas-Aasen, C Gaarder, K Brohi, S Eaglestone, S Stanworth, P I Johansson, S R Ostrowski, J Stensballe, M Maegele, J C Goslings, N P Juffermans
BACKGROUND: The combined effects of balanced transfusion ratios and use of procoagulant and antifibrinolytic therapies on trauma-induced exsanguination are not known. The aim of this study was to investigate the combined effect of transfusion ratios, tranexamic acid and products containing fibrinogen on the outcome of injured patients with bleeding. METHODS: A prospective multicentre observational study was performed in six level 1 trauma centres. Injured patients who received at least 4 units of red blood cells (RBCs) were analysed and divided into groups receiving a low (less than 1 : 1) or high (1 or more : 1) ratio of plasma or platelets to RBCs, and in receipt or not of tranexamic acid or fibrinogen products (fibrinogen concentrates or cryoprecipitate)...
January 12, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28077524/when-more-is-less-efficacious-fibrinogen-concentrate-in-complex-cardiac-surgery
#4
EDITORIAL
A K Davis
No abstract text is available yet for this article.
October 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28075404/advanced-oxidation-protein-products-modified-albumin-induces-differentiation-of-raw264-7-macrophages-into-dendritic-like-cells-which-is-modulated-by-cell-surface-thiols
#5
Silvano Garibaldi, Chiara Barisione, Barbara Marengo, Pietro Ameri, Claudio Brunelli, Manrico Balbi, Giorgio Ghigliotti
Local accumulation of Advanced Oxidation Protein Products (AOPP) induces pro-inflammatory and pro-fibrotic processes in kidneys and is an independent predictor of renal fibrosis and of rapid decline of eGFR in patients with chronic kidney disease (CKD). In addition to kidney damage, circulating AOPP may be regarded as mediators of systemic oxidative stress and, in this capacity, they might play a role in the progression of atherosclerotic damage of arterial walls. Atherosclerosis is a chronic inflammatory disease that involves activation of innate and adaptive immunity...
January 10, 2017: Toxins
https://www.readbyqxmd.com/read/28074548/annual-report-of-the-perinatology-committee-japan-society-of-obstetrics-and-gynecology-2015-proposal-of-urgent-measures-to-reduce-maternal-deaths
#6
Satoru Takeda, Jun Takeda, Keisuke Murakami, Takahiko Kubo, Hiromi Hamada, Maki Murakami, Shintaro Makino, Hiroaki Itoh, Takashi Ohba, Katsuhiko Naruse, Hiroaki Tanaka, Naohiro Kanayama, Shigeki Matsubara, Hiroshi Sameshima, Tomoaki Ikeda
Perinatal care in Japan has progressed rapidly in recent decades, remarkably reducing maternal, perinatal and neonatal mortality rates. This is attributable not only to the sustained efforts and dedication of past obstetricians and midwives, but also to the collective results achieved by the Japan Society of Obstetrics and Gynecology and healthcare administration, including research on advanced medical care, education, medical care improvements and establishing perinatal care centers. Although the maternal mortality rate was in steady decline until 2007 (3...
January 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28067100/effects-of-a-single-bout-of-strenuous-exercise-on-platelet-activation-in-female-apoe-ldlr-mice
#7
K Przyborowski, H Kassassir, M Wojewoda, K Kmiecik, B Sitek, K Siewiera, A Zakrzewska, A M Rudolf, R Kostogrys, C Watala, J A Zoladz, S Chlopicki
Strenuous physical exercise leads to platelet activation that is normally counterbalanced by the production of endothelium-derived anti-platelet mediators, including prostacyclin (PGI2) and nitric oxide (NO). However, in the case of endothelial dysfunction, e.g. in atherosclerosis, there exists an increased risk for intravascular thrombosis during exercise that might be due to an impairment in endothelial anti-platelet mechanisms. In the present work, we evaluated platelet activation at rest and following a single bout of strenuous treadmill exercise in female ApoE/LDLR(-)(/-) mice with early (3-month-old) and advanced (7-month-old) atherosclerosis compared to female age-matched WT mice...
January 9, 2017: Platelets
https://www.readbyqxmd.com/read/28057902/are-pulmonary-haemostasis-and-fibrinolysis-out-of-balance-in-equine-chronic-pneumopathies
#8
Ann Kristin Barton, Caroline Wirth, Angelika Bondzio, Ralf Einspanier, Heidrun Gehlen
Results of clinical examination, bronchoalveolar lavage fluid (BALF) cytology, acute phase proteins and markers of pulmonary haemostasisand fibrinolysis (fibrinogen, serum amyloid A, D-dimers) were compared between controls and horses affected by respiratory disease. Using a clinical scoring system, 58 horses were classified as free of respiratory disease (controls, n=15), recurrent airway obstruction (RAO, n=18), inflammatory airway disease (IAD, n=14) or chronic interstitial pneumopathy (CIP, n=11). No significant differences were found in fibrinogen concentration, but descriptive data analysis showed a trend towards lower values for controls (median 0...
January 4, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28057488/exploring-hemostatic-and-thrombolytic-potential-of-heynein-a-cysteine-protease-from-ervatamia-heyneana-latex
#9
Priyanka Uday, M Maheshwari, P Sharanappa, Zohara Nafeesa, Vivek Hamse Kameshwar, B S Priya, S Nanjunda Swamy
ETHNOPHARMACOLOGIAL RELEVANCE: The latex of Ervatamia heyneana (Wall.) T. Cooke plant has been used for wound healing and various skin diseases by Indian tribes and folklore. AIM OF THE STUDY: To validate the scientific basis of heynein - a key protease of Ervatamia heyneana, in hemostasis and wound healing process. MATERIALS AND METHODS: The latex from E. heyneana was processed and subjected to two step purification. The purified heynein was assayed for proteolytic activity using casein as substrate and also attested by zymography...
January 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28032468/three-dimensional-culture-of-single-embryonic-stem-derived-neural-stem-progenitor-cells-in-fibrin-hydrogels-neuronal-network-formation-and-matrix-remodelling
#10
Ana R Bento, Pedro Quelhas, Maria J Oliveira, Ana P Pêgo, Isabel F Amaral
In an attempt to improve the efficacy of neural stem/progenitor cell (NSPC) based therapies, fibrin hydrogels are being explored to provide a favourable microenvironment for cell survival and differentiation following transplantation. In the present work, the ability of fibrin to support the survival, proliferation, and neuronal differentiation of NSPCs derived from embryonic stem (ES) cells under monolayer culture was explored. Single mouse ES-NSPCs were cultured within fibrin (fibrinogen concentration: 6 mg/ml) under neuronal differentiation conditions up to 14 days...
December 29, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28030952/calcium-stearate-as-an-effective-alternative-to-poly-vinyl-alcohol-in-poly-lactic-co-glycolic-acid-nanoparticles-synthesis
#11
Claudia Cella, Irini Gerges, Paolo Milani, Cristina Lenardi, Simona Argentiere
Poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles(NPs) are among the most studied systems for drug and gene targeting. So far, the synthesis of stable and uniform PLGA NPs has involved the use of a large excess of polyvinyl surfactants such as polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP), whose removal requires multi-step purification procedures of high ecological and economic impact. Hence the development of environment-friendly and cost-effective synthetic procedures for the synthesis of PLGA NPs would effectively boost their use in clinics...
December 28, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/28030939/evaluation-of-vcam-1-and-icam-1-concentration-and-values-of-global-tests-concerning-the-coagulation-system-of-patients-suffering-from-subarachnoid-haemorrage
#12
Abu-Sitta Al-Drawi, Michał Wiciński, Grzegorz Grześk, Katarzyna Szadujkis-Szadurska, Elżbieta Grześk, Mateusz Maciej Węclewicz, Agnieszka Michalska, Anna Czeczuk, Elżbieta Huk-Wieliczuk
INTRODUCTION: The term 'subarachnoid haemorrhage' (SAH) stands for bleeding into the subarachnoid space, regardless of its source. It may be of primary character when the source of bleeding is situated within the subarachnoid space. Subarachnoid haemorrhage is often described as spontaneous bleeding, mainly in order to differentiate it from post-traumatic bleeding. OBJECTIVE: The aim of the study was to evaluate the concentration of ICAM-1 and VCAM-1 in the blood of patients in the early phase following subarachnoid haemorrhage in terms of searching for markers useful in subarachnoid bleeding diagnostics and monitoring a patient's clinical state...
23, 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28028981/assessment-of-selected-rotem-parameters-kinetics-of-fibrinogen-polymerization-and-plasmin-amidolytic-activity-in-patients-with-congenital-fibrinogen-defects
#13
Jacek Treliński, Katarzyna Pachniewska, Justyna Matczak, Marta Robak, Krzysztof Chojnowski
BACKGROUND: Congenital fibrinogen disorders (CFD) are rare fibrinogen deficiencies which may be quantitative or functional. The clinical course of hypofibrinogenemia (hypoFI) or dysfibrinogenemia (dysFI) is unpredictable and cannot be determined by the application of standard hemostasis tests. OBJECTIVES: The main aim of this study was to assess ROTEM parameters in CFD patients. MATERIAL AND METHODS: Nine patients with CFD were studied. The fibrinogen concentration was measured functionally and antigenically...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28024202/microcontact-imprinted-quartz-crystal-microbalance-nanosensor-for-protein-c-recognition
#14
Monireh Bakhshpour, Erdoğan Özgür, Nilay Bereli, Adil Denizli
Detection of protein C (PC) in human serum was performed by quartz crystal microbalance (QCM) based on molecular imprinting technique (MIP). The high-resolution and mass-sensitive QCM based sensor was integrated with high sensitivity and selectivity of the MIP technique. The PC microcontact imprinted (PC-μCIP) nanofilm was prepared on the glass surface. Then, the PC-μCIP/QCM sensor was prepared with 2-hydroxyethyl methacrylate (HEMA), ethylene glycol dimethacrylate (EGDMA) and N-methacryloyl l-histidine methylester (MAH) as the functional monomer with copper(II) ions...
December 15, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28013317/determination-of-serum-neutrophil-gelatinase-associated-lipocalin-at-the-early-stage-of-acute-pancreatitis
#15
Mateusz Sporek, Paulina Dumnicka, Agnieszka Gala-Błądzińska, Małgorzata Mazur-Laskowska, Jerzy Walocha, Piotr Ceranowicz, Zygmunt Warzecha, Artur Dembiński, Marek Kuźniewski, Rafał Olszanecki, Beata Kuśnierz-Cabala
AIM: e aim of the study was to assess the diagnostic value of serum concentrations of neutrophil gelatinase-associated lipocalin (sNGAL) for the determination of the severity of acute pancreatitis (AP) at the early stage of the disease. MATERIALS AND METHOD: The study group consisted of 65 patients(34 men and 31 women),aged 62.2 ± 16.0, admitted to the Surgery Department of the District Hospital in Sucha Beskidzka, Poland, with the diagnosis of AP according to the revised Atlanta classification (2012)...
2016: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/28001309/platelet-responses-to-agonists-in-a-cohort-of-highly-characterised-platelet-donors-are-consistent-over-time
#16
S F Garner, A Furnell, B C Kahan, C I Jones, A Attwood, P Harrison, A M Kelly, A H Goodall, R Cardigan, W H Ouwehand
BACKGROUND AND OBJECTIVES: Platelet function shows significant inheritance that is at least partially genetically controlled. There is also evidence that the platelet response is stable over time, but there are few studies that have assessed consistency of platelet function over months and years. We aimed to measure platelet function in platelet donors over time in individuals selected from a cohort of 956 donors whose platelet function had been previously characterised. MATERIALS AND METHODS: Platelet function was assessed by flow cytometry, measuring fibrinogen binding and P-selectin expression after stimulation with either cross-linked collagen-related peptide or adenosine 5'-diphosphate...
January 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28000366/hemocompatiblilty-evaluation-of-poly-1-8-octanediol-citrate-blend-polyethersulfone-membranes
#17
Muhamad Zulhilmi Zailani, Ahmad Fauzi Ismail, Siti Hamimah Sheikh Abdul Kadir, Mohd Hafiz Dzarfan Othman, Pei Sean Goh, Hasrinah Hasbullah, Mohd Sohaimi Abdullah, Be Cheer Ng, Fatmawati Kamal
In this study, poly (1,8- octanediol citrate) (POC) was used to modify polyethersufone (PES) based membrane to enhance its hemocompatibility. Different compositions of POC (0-3%) were added into the polyethersulfone (PES) dope solutions and polyvinylpyrrolidone (PVP) was used as pore forming agent. The hemocompatible POC modified PES membranes were fabricated through phase-inversion technique. The prepared membranes were characterized using attenuated total reflectance-fourier transform infrared (ATR-FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), Atomic-force microscopy (AFM), contact angle, Zeta-potential, membrane porosity and pore size and pure water flux (PWF) and BSA rejection...
December 21, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27989295/systemic-inflammation-in-midlife-race-socioeconomic-status-and-perceived-discrimination
#18
Irena Stepanikova, Lori Brand Bateman, Gabriela R Oates
INTRODUCTION: This study investigates social determinants of systemic inflammation, focusing on race, SES, and perceived discrimination. METHODS: Data on 884 white and 170 black participants were obtained from the Survey of Midlife in the U.S., a cross-sectional observational study combining survey measures, anthropometry, and biomarker assay. Data, collected in 2004-2009, were analyzed in 2016. Main outcome measures were fasting blood concentrations of C-reactive protein, interleukin 6, fibrinogen, and E-selectin...
January 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27986842/effect-of-occupational-exposure-to-lead-on-new-risk-factors-for-cardiovascular-diseases
#19
Adam Prokopowicz, Andrzej Sobczak, Magdalena Szuła-Chraplewska, Marzena Zaciera, Jolanta Kurek, Izabela Szołtysek-Bołdys
OBJECTIVE: The cardiovascular effects of lead are caused primarily through an effect on blood pressure but are not just limited to an increased risk of hypertension. The aim of our study was to determine to what extent chronic exposure to lead affects new risk factors for cardiovascular disease (CVD) development, such as biomarkers of inflammation (C reactive protein (CRP) and fibrinogen) and biomarkers of endothelial dysfunction (homocysteine, asymmetric dimethylarginine (ADMA) and L-homoarginine)...
December 16, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27975099/paradoxical-bleeding-and-thrombotic-episodes-of-dysprothrombinaemia-due-to-a-homozygous-arg382his-mutation
#20
Qiulan Ding, Likui Yang, Xiaoqing Zhao, Wenman Wu, Xuefeng Wang, Alireza R Rezaie
We have characterised the pathogenic basis of dysprothrombinaemia in a patient exhibiting paradoxical bleeding and thrombotic defects during pregnancy and postpartum. Genetic analysis revealed that the proband is homozygous for the prothrombin Arg382His mutation, possessing only ~1 % clotting activity. The proband experienced severe bleeding episodes during her pregnancy, which required treatment with prothrombin complex concentrates, and then pulmonary embolism and deep-vein thrombosis at 28 days postpartum, which required treatment with LMWH and fresh frozen plasma...
December 15, 2016: Thrombosis and Haemostasis
keyword
keyword
5356
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"