Giulia Anzalone, Rosalia Gagliardo, Fabio Bucchieri, Giusy Daniela Albano, Liboria Siena, Angela Marina Montalbano, Anna Bonanno, Loredana Riccobono, Michael Paul Pieper, Mark Gjomarkaj, Mirella Profita
AIMS: IL-17A plays a key role in the persistence of airway inflammation, oxidative stress, and reduction of steroid-sensitivity in COPD. We studied the effect of IL-17A on chromatin remodeling and IL-8 production. MAIN METHODS: We measured the levels of IL-8 and IL-17A in induced sputum supernatants (ISS) from healthy controls (HCs), healthy smokers (HSs), and COPD patients by enzyme-linked immunosorbent assay (ELISA). A human bronchial epithelial cell line (16HBE) was stimulated with ISS from HCs, HSs, or COPD subjects...
May 1, 2016: Life Sciences