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Crescentic glomerulonephritis

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https://www.readbyqxmd.com/read/29901005/pauci-immune-crescentic-glomerulonephritis-in-a-patient-with-immunoglobulin-a-nephropathy-and-serum-antineutrophil-cytoplasmic-autoantibody-positivity
#1
Keren Cohen-Hagai, Sydney Benchetrit, Osnat Klein, Yona Kitay-Cohen, Ze'ev Korzets
No abstract text is available yet for this article.
March 2018: Archives of Rheumatology
https://www.readbyqxmd.com/read/29879042/pulmonary-renal-syndrome-a-case-report-of-diffuse-alveolar-hemorrhage-in-association-with-anca-negative-pauci-immune-glomerulonephritis
#2
Lakshmi Saladi, Danial Shaikh, Muhammad Saad, Enny Cancio-Rodriguez, Vivette D D'Agati, Boris Medvedovsky, Kalpana A Uday, Muhammad Adrish
RATIONALE: Pulmonary renal syndrome (PRS) is a term most commonly used to describe a combination of glomerulonephritis and pulmonary hemorrhage as a manifestation of a multisystem autoimmune disease. It is usually associated with ANCA vasculitis and anti-GBM disease. Diffuse alveolar hemorrhage in a patient with ANCA and anti-GBM negative pauci-immune glomerulonephritis is rare and optimal management is unknown. PATIENT CONCERNS: An 85-year-old man with hypertension, diabetes mellitus, prostate cancer and recently diagnosed pauci-immune necrotizing glomerulonephritis presented to our emergency department with worsening dyspnea and pedal edema for several days...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29877285/successful-treatment-of-iga-vasculitis-complicated-with-bowel-perforation-and-crescentic-glomerulonephritis-by-combination-therapy-of-glucocorticoid-cyclosporine-and-factor-xiii-replacement
#3
Keiko Koshiba, Sei Muraoka, Toshihiro Nanki, Satoru Komatsumoto
We report the findings of an 18-year-old boy with immunoglobulin A vasculitis (IgAV) complicated with bowel perforation and nephritis. He presented with abdominal pain, arthralgia and palpable purpura. Massive proteinuria developed during his clinical course. The patient was treated successfully using combination therapy of glucocorticoid (GC), cyclosporine (CYA) and factor XIII (F XIII) replacement. A standard treatment strategy for severe IgAV patients has not been established due to its rarity. Combination therapy using GC, CYA and F XIII replacement should be considered for severe IgAV patients...
June 6, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29872033/co-presentation-of-giant-cell-arteritis-and-granulomatosis-with-polyangiitis-a-case-report-and-review-of-literature
#4
Haitham H Hassane, Mirza M Beg, Chokkalingam Siva, Celso Velázquez
BACKGROUND Systemic vasculitis can present with a multitude of symptoms involving multiple organ systems. Clinicians should avoid anchoring bias and be cognizant that different types of vasculitides can be present in the same patient and that the diagnosis of one should not preclude the subsequent diagnosis of another. CASE REPORT A 67-year-old woman was referred for evaluation of episodes of epistaxis and recurrent severe sinusitis. Her physical examination showed nasal congestion and purpuric rash on the lower extremities...
June 6, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29859097/selective-pharmacological-inhibition-of-ddr1-prevents-experimentally-induced-glomerulonephritis-in-prevention-and-therapeutic-regime
#5
Solange Moll, Yukari Yasui, Ahmed Abed, Takeshi Murata, Hideaki Shimada, Akira Maeda, Naoshi Fukushima, Masakazu Kanamori, Sabine Uhles, Laura Badi, Thomas Cagarelli, Ivan Formentini, Faye Drawnel, Guy Georges, Tobias Bergauer, Rodolfo Gasser, R Daniel Bonfil, Rafael Fridman, Hans Richter, Juergen Funk, Marcus J Moeller, Christos Chatziantoniou, Marco Prunotto
BACKGROUND: Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase extensively implicated in diseases such as cancer, atherosclerosis and fibrosis. Multiple preclinical studies, performed using either a gene deletion or a gene silencing approaches, have shown this receptor being a major driver target of fibrosis and glomerulosclerosis. METHODS: The present study investigated the role and relevance of DDR1 in human crescentic glomerulonephritis (GN)...
June 1, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29802527/recurrence-of-crescentic-iga-nephropathy-after-renal-transplantation
#6
Georgios Zagkotsis, Christina Vourlakou, Aristeidis Paraskevopoulos, Theofanis Apostolou
IgA nephropathy (IgAN) is one of the most common recurrent glomerulonephritis after renal transplantation. Rarely, it is accompanied with the presence of crescents that leads to rapid deterioration of renal function and graft loss. We present a 54-year-old patient with IgAN that received a cadaveric kidney allograft, but developed biopsy proven recurrent IgAN 7 months after renal transplantation. He was treated with intravenous steroids and angiotensin-converting enzyme inhibitor and remission was achieved...
May 25, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29791907/toll-like-receptor-3-signaling-contributes-to-regional-neutrophil-recruitment-in-cultured-human-glomerular-endothelial-cells
#7
Qiang Liu, Tadaatsu Imaizumi, Shogo Kawaguchi, Tomomi Aizawa, Tomoh Matsumiya, Shojiro Watanabe, Koji Tsugawa, Hidemi Yoshida, Kazushi Tsuruga, Kensuke Joh, Hiroshi Kijima, Hiroshi Tanaka
BACKGROUND: Given the importance of neutrophil recruitment in the pathogenesis of glomerulonephritis (GN), the representative neutrophil chemoattractant C-X-C motif chemokine 1 (CXCL1)/GROα and the adhesion molecule E-selectin in glomerular endothelial cells (GECs) play a pivotal role in the development of GN. Endothelial Toll-like receptor 3 (TLR3) is thought to be involved in the inflammatory response via innate immunity. However, the role of endothelial TLR3 signaling in the expression of neutrophil chemoattractants and adhesion molecules remains to be elucidated...
May 23, 2018: Nephron
https://www.readbyqxmd.com/read/29790004/exploring-sex-specific-differences-in-the-presentation-and-outcomes-of-anca-associated-vasculitis-a-nationwide-registry-based-cohort-study
#8
Rune Bjørneklett, Vilde Solbakken, Leif Bostad, Anne-Siri Fismen
PURPOSE: Sex-specific differences in the risk of end-stage renal disease (ESRD) in patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) stratified by histological classification have not been previously investigated. METHODS: Patients with biopsy-verified pauci-immune necrotizing GN and positive ANCA serology in the Norwegian Kidney Biopsy Registry between 1991 and 2012 were included. Patients with ESRD during follow-up were identified from the Norwegian Renal Registry...
May 22, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29766817/characteristics-and-outcomes-of-patients-with-anti-glomerular-basement-membrane-antibody-disease-and-anti-neutrophil-cytoplasmic-antibodies
#9
Percy Balderia, Nicole Andeen, Jonathan Ashley Jefferson
BACKGROUND: It is unclear whether patients with anti-glomerular basement membrane (GBM) disease and anti-neutrophil cytoplasmic antibodies (ANCA), so called "double-positive" (DP), have a different clinical presentation and outcome compared to patients with anti-GBM antibody disease alone. This study describes the clinical and histologic characteristics as well as the patient and renal outcomes of DP patients at the University of Washington compared to patients with anti-GBM antibody disease alone...
May 16, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29738576/distinct-characteristics-and-outcomes-in-elderly-onset-iga-vasculitis-henoch-sch%C3%A3-nlein-purpura-with-nephritis-nationwide-cohort-study-of-data-from-the-japan-renal-biopsy-registry-j-rbr
#10
Hiroyuki Komatsu, Shouichi Fujimoto, Shoichi Maruyama, Masashi Mukoyama, Hitoshi Sugiyama, Kazuhiko Tsuruya, Hiroshi Sato, Jun Soma, Junko Yano, Seiji Itano, Tomoya Nishino, Toshinobu Sato, Ichiei Narita, Hitoshi Yokoyama
BACKGROUND: The clinical presentation and prognosis of adult and elderly patients with IgA vasculitis (Henoch-Schönlein purpura) accompanied by nephritis (IgAV-N) have not been investigated in detail. We therefore surveyed the features and outcomes of IgAV-N based on nationwide data derived from the Japan Renal Biopsy Registry (J-RBR). METHODS: This multi-center cohort study compared the clinicopathological parameters at diagnosis, initial therapies and outcomes between 106 adult (age 19-64 years) and 46 elderly (≥65 years) patients with IgAV-N who were registered in the J-RBR between 2007 and 2012...
2018: PloS One
https://www.readbyqxmd.com/read/29738027/hydralazine-associated-adverse-events-a-report-of-two-cases-of-hydralazine-induced-anca-vasculitis
#11
Roman Zuckerman, Mayurkumar Patel, Eric J Costanzo, Harry Dounis, Rany Al Haj, Seyedehsara Seyedali, Arif Asif
Hydralazine is a direct-acting vasodilator, which has been used in treatment for hypertension (HTN) since the 1950s. While it is well known to cause drug-induced lupus (DIL), recent reports are indicating the emergence of the drug-induced anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (DIV). Herein, we describe two patients (aged 57 and 87 years) who presented with severe acute kidney injury (AKI), proteinuria, and hematuria. Both were receiving hydralazine for the treatment of hypertension...
May 7, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29733413/urinary-angiotensinogen-an-indicator-of-active-antineutrophil-cytoplasmic-antibody-associated-glomerulonephritis
#12
Liling Wu, Manqiu Yang, Xiaogang Feng, Lingwei Jin, Chunyi Wu, Shuang Cui, Zhanmei Zhou, Xiaohong Zhong, Meng Shi, Zhichen Yang, Wei Cao
Background: One of the major challenges in improving the management of antineutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) is the lack of a disease-specific indicator for histological lesions and disease activity. Here we tested the utility of urinary angiotensinogen (UAGT) as a biomarker of renal disease activity in ANCA-GN. Methods: A prospective, two-stage cohort study was performed in ANCA-GN patients. In Stage I, UAGT was measured at the time of renal biopsy in 69 patients from two centers (test set) and 25 patients from two other centers (validation set)...
May 4, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29717936/different-effects-of-global-osteopontin-and-macrophage-osteopontin-in-glomerular-injury
#13
Jessica Trostel, Luan D Truong, Carlos A Roncal-Jimenez, Makoto Miyazaki, Shinobu Miyazaki-Anzai, Masanari Kuwabara, Rachel H McMahan, Ana Andres-Hernando, Yuka Sato, Thomas Jensen, Miguel A Lanaspa, Richard J Johnson, Gabriela E Garcia
Osteopontin (OPN) is a pro-and ant-inflammatory molecule that simultaneously attenuates oxidative stress. Both inflammation and oxidative stress play a role in the pathogenesis of glomerulonephritis and in the progression of kidney injury. Importantly, OPN is highly induced in nephritic kidney. To further characterize the role of OPN in kidney injury we used OPN-/- mice in anti-glomerular basement membrane reactive serum-induced immune nephritis (NTS), an inflammatory and progressive model of kidney disease...
May 2, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29657200/complementary-bodybuilding-a-potential-risk-for-permanent-kidney-disease
#14
Wael El-Reshaid, Kamel El-Reshaid, Shaikha Al-Bader, Ahmad Ramadan, John Patrick Madda
We report our experience of renal disease associated with bodybuilders who had been on high-protein diet, anabolic androgenic steroids (AASs), and growth hormone (GH) for years. A total of 22 adult males who volunteered information about use of high protein diet and AAS or GH were seen over a six-year period with renal disease. Kidney biopsy revealed focal segmental glomerulosclerosis (FSGS) in eight, nephroangiosclerosis in four, chronic interstitial nephritis in three, acute interstitial nephritis in two, nephrocalcinosis with chronic interstitial nephritis in two, and single patients with membranous glomerulopathy, crescentic glomerulopathy, and sclerosing glomerulonephritis...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29594143/a-case-of-crescentic-glomerulonephritis-complicated-with-hypocomplementemic-urticarial-vasculitis-syndrome-and-anca-associated-vasculitis
#15
Marenao Tanaka, Norihito Moniwa, Tomohiro Mita, Toshiyuki Tobisawa, Tamaki Matsumoto, Atsushi Mochizuki, Tomohisa Yamashita, Toshiyuki Yano, Masato Furuhashi, Tetsuji Miura
Systemic urticaria in a 64-year-old woman was diagnosed as leukocytoclastic vasculitis by a punch biopsy of the skin. Her physical findings improved after prescription of prednisolone at a dose of 20 mg/day, but the skin rash relapsed with renal dysfunction, proteinuria, and hematuria when the dose of prednisolone was reduced over a period of 9 months to 1 mg/day. She was admitted to our institute for further examination, when urinary protein and plasma creatinine levels were 0.8 g/day and 1.7 mg/dL, respectively...
September 2017: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29594142/rare-bacteria-infecting-the-heart-and-affecting-the-kidney-of-a-young-child
#16
Gurinder Kumar, Alyaa Saeed Al Ali, Namrata Gulzar Bhatti
Rare bacteria can lead to infective endocarditis, which may lead to renal involvement as severe glomerulonephritis. We report our experience of a 12-year-old child who presented with infective endocarditis and blood culture-grown Gemella morbillorum - a rarely reported bacteria. The clinical picture was further complicated with severe glomerulonephritis. Renal biopsy was suggestive of crescentic glomerulonephritis. The child was managed with antibiotics, steroids, and plasmapheresis and responded well to the treatment...
September 2017: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29578397/fibrillary-glomerulonephritis-in-an-hiv-patient-without-concurrent-hepatitis-c-infection-case-report-and-review-of-the-literature
#17
Lian Zhang, John M Carson, M Scott Lucia
The most common renal disease associated with human immunodeficiency virus infection (HIV) is HIV-associated nephropathy (HIVAN), especially in the African American patient population. However, various patterns of glomerulonephritis (GN) are not uncommon, collectively accounting for nearly half of the renal biopsies performed in HIV patients. Most GNs that occur in HIV patients are immune complex mediated, often with concurrent infections such as hepatitis B or C. Fibrillary glomerulonephritis (FGN), a rare primary glomerular disease, has only been reported in 2 HIV patients, and both patients had concurrent hepatitis C (HCV) infection...
May 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29564665/the-features-in-iga-dominant-infection-related-glomerulonephritis-distinct-from-iga-nephropathy-a-single-center-study
#18
Takaya Handa, Hiroko Kakita, Yu Tateishi, Tomomi Endo, Hiroyuki Suzuki, Toshiro Katayama, Tatsuo Tsukamoto, Eri Muso
BACKGROUND: IgA-dominant infection-related glomerulonephritis (IgA-IRGN) is a unique form of IRGN, which needs to be distinguished from IgA nephropathy (IgAN). METHODS: Thirteen patients with IgA-IRGN (IgA-IRGN group) and 122 with IgAN (IgAN group) were selected from 1788 patients who underwent kidney biopsy between 2000 and 2015 in Kitano Hospital. Data selected included clinical and serological parameters; light and electron microscope findings; immunofluorescence findings; and prognostic parameters like renal and overall survival and creatinine increase by > 50%...
March 21, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29519741/hydralazine-associated-vasculitis-overlapping-features-of-drug-induced-lupus-and-vasculitis
#19
Bharat Kumar, Jennifer Strouse, Melissa Swee, Petar Lenert, Manish Suneja
INTRODUCTION: Hydralazine is an antihypertensive medication that has been associated with drug-induced lupus erythematosus (DIL) as well as ANCA-associated vasculitis (AAV). Although rare, early diagnosis is critical since drug cessation is the mainstay of therapy. This retrospective study aims to characterize the clinical, laboratory, and histopathologic features of this disease. METHODS: Once approval was obtained from the Institutional Review Board at the University of Iowa, all patients carrying a diagnosis of vasculitis (ICD9 code: 447...
January 12, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29515299/mycophenolate-versus-cyclophosphamide-for-lupus-nephritis
#20
M Sahay, Y Saivani, K Ismal, P S Vali
Systemic lupus erythematosus is common in our country, and renal involvement is an important cause of chronic kidney disease. This study was aimed at comparing the three regimens, i.e., cyclophosphamide-based regimes (low dose and high dose) and mycophenolate mofetil (MMF)-based regime and determining if cyclophosphamide (CPM)-based regime can be an effective, safe, and cheap alternative to MMF-based regime in a resource-limited setting. Out of 144 patients, females constituted 89%. Nephrotic nephritic presentation was the most common...
January 2018: Indian Journal of Nephrology
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