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Gerard McMahon, Christopher I Morse, Keith Winwood, Adrian Burden, Gladys L Onambélé
PURPOSE: To compare the relative changes in muscle-tendon complex (MTC) properties following high load resistance training (RT) in young males and females, and determine any link with circulating TGFβ-1 and IGF-I levels. METHODS: Twenty-eight participants were assigned to a training group and subdivided by sex (T males [TM] aged 20±1 year, n = 8, T females [TF] aged 19±3 year, n = 8), whilst age-matched 6 males and 6 females were assigned to control groups (ConM/F)...
2018: PloS One
Michael A Zacchilli, Amos Z Dai, Eric J Strauss, Laith M Jazrawi, Robert J Meislin
The meniscus plays a vital role in knee biomechanics, and its physical absence or functional incompetence (e.g., irreparable root or radial tear) leads to unacceptably high rates of joint degeneration in affected populations. Meniscal allograft transplantation has been used successfully to treat patients with postmeniscectomy syndrome, and there is early laboratory and radiographic evidence hinting at a potential prophylactic role in preventing joint degeneration. We present a technique for lateral meniscal allograft transplantation using the CONMED Meniscal Allograft Transplantation system...
December 2017: Arthroscopy Techniques
Wan-Fa Tian, Dang-Po Wang, Shao-Feng Wang, Ke-Han He, Xiao-Ping Cao, Yang Li
An unprecedented visible-light photoredox-catalyzed iminyl radical formation by N-H cleavage with H2 release has been developed. Its application in the synthesis of various isoquinolines and related polyaromatics in high atom economy at ambient temperature by applying a photosensitizer, Acr+ -Mes ClO4 - , and a new cobalt catalyst, Co(dmgH)2 (4-CONMe2 Py)Cl is reported. Mechanistic investigations indicated that the generated iminyl radical initiates the cascade C-N/C-C bonds formation and the catalytic cycle occurs by a simultaneous oxidative as well as reductive quenching pathway...
March 2, 2018: Organic Letters
Jin Cheng, Siddhartha Venkata Paluvadi, SungJae Lee, SeungJin Yoo, Eun-Kyoo Song, Jong-Keun Seon
PURPOSE: Cortical suspensory devices are routinely used for femoral side fixation of soft tissue graft in anterior cruciate ligament (ACL) reconstruction. The purpose of this study was to evaluate the biomechanical properties of a new adjustable loop device (GraftMax®) compared with established devices (EndoButton® and TightRope®) in ACL reconstruction and to investigate whether knotting the free end of TightRope could improve biomechanical properties. METHODS: The three cortical suspensory devices (GraftMax® Button; Conmed, EndoButton® CL; Smith & Nephew, and TightRope® RT; Arthrex) were tested under cyclic load (50-250 N for 1000 cycles) and pull-to-failure conditions at 50 mm/h in a device-only setup using a tensile testing machine...
January 29, 2018: International Orthopaedics
Ana C S Gondim, Isolda Romero-Canelón, Eduardo H S Sousa, Claudia A Blindauer, Jennifer S Butler, María J Romero, Carlos Sanchez-Cano, Bruno L Sousa, Renata P Chaves, Celso S Nagano, Benildo S Cavada, Peter J Sadler
The lectin DLasiL was isolated from seeds of the Dioclea lasiocarpa collected from the northeast coast of Brazil and characterized for the first time by mass spectrometry, DNA sequencing, inductively coupled plasma-mass spectrometry, electron paramagnetic resonance, and fluorescence spectroscopy. The structure of DLasiL lectin obtained by homology modelling suggested strong conservation of the dinuclear Ca/Mn and sugar-binding sites, and dependence of the solvent accessibility of tryptophan-88 on the oligomerisation state of the protein...
October 2017: Journal of Inorganic Biochemistry
N S Nagra, N Zargar, R D J Smith, A J Carr
OBJECTIVES: All-suture anchors are increasingly used in rotator cuff repair procedures. Potential benefits include decreased bone damage. However, there is limited published evidence for the relative strength of fixation for all-suture anchors compared with traditional anchors. MATERIALS AND METHODS: A total of four commercially available all-suture anchors, the 'Y-Knot' (ConMed), Q-FIX (Smith & Nephew), ICONIX (Stryker) and JuggerKnot (Zimmer Biomet) and a traditional anchor control TWINFIX Ultra PK Suture Anchor (Smith & Nephew) were tested in cadaveric human humeral head rotator cuff repair models (n = 24)...
February 2017: Bone & Joint Research
Shannon W Hill, Christopher R Chapman, Samer Adeeb, Kajsa Duke, Lauren Beaupre, Martin J Bouliane
BACKGROUND: The Nice knot is a bulky double-stranded knot. Biomechanical data supporting its use as well as the number of half hitches required to ensure knot security is lacking. MATERIALS AND METHODS: Nice knots with, one, two, or three half-hitches were compared with the surgeon's and Tennessee slider knots with three half hitches. Each knot was tied 10 times around a fixed diameter using four different sutures: FiberWire (Arthrex, Naples, FL), Ultrabraid (Smith and Nephew, Andover, MA), Hi-Fi (ConMed Linvatec, Largo, FL) and Force Fiber (Teleflex Medical OEM, Gurnee, IL)...
January 2016: International Journal of Shoulder Surgery
Shou-Jiang Tang, Andreas S Vilmann, Adrian Saftoiu, Wanmei Wang, Costin Teodor Streba, Peter P Fink, Michael Griswold, Ruonan Wu, Christoph F Dietrich, Christian Jenssen, Michael Hocke, Marcus Kantowski, Jürgen Pohl, Paul Fockens, Jouke T Annema, Erik H F M van der Heijden, Roald Flesland Havre, Khanh Do-Cong Pham, Rastislav Kunda, Pierre H Deprez, Jinga Mariana, Enrique Vazquez-Sequeiros, Alberto Larghi, Elisabetta Buscarini, Pietro Fusaroli, Maor Lahav, Rajesh Puri, Pramod Kumar Garg, Malay Sharma, Fauze Maluf-Filho, Anand Sahai, William R Brugge, Linda S Lee, Harry R Aslanian, Andrew Y Wang, Vanessa M Shami, Arnold Markowitz, Ali A Siddiqui, Girish Mishra, James M Scheiman, Gerard Isenberg, Uzma D Siddiqui, Raj J Shah, James Buxbaum, Rabindra R Watson, Field F Willingham, Manoop S Bhutani, Michael J Levy, Cynthia Harris, Michael B Wallace, Christian Pállson Nolsøe, Torben Lorentzen, Niels Bang, Sten Mellerup Sørensen, Odd Helge Gilja, Mirko D'Onofrio, Fabio Piscaglia, Norbert Gritzmann, Maija Radzina, Zeno Adrian Sparchez, Paul S Sidhu, Simon Freeman, Timothy C McCowan, Cyrillo Rodrigues de Araujo, Akash Patel, Mohammad Adel Ali, Garth Campbell, Edward Chen, Peter Vilmann
BACKGROUND AND AIMS: EUS-guided FNA or biopsy sampling is widely practiced. Optimal sonographic visualization of the needle is critical for image-guided interventions. Of the several commercially available needles, bench-top testing and direct comparison of these needles have not been done to reveal their inherent echogenicity. The aims are to provide bench-top data that can be used to guide clinical applications and to promote future device research and development. METHODS: Descriptive bench-top testing and comparison of 8 commonly used EUS-FNA needles (all size 22 gauge): SonoTip Pro Control (Medi-Globe); Expect Slimline (Boston Scientific); EchoTip, EchoTip Ultra, EchoTip ProCore High Definition (Cook Medical); ClearView (Conmed); EZ Shot 2 (Olympus); and BNX (Beacon Endoscopic), and 2 new prototype needles, SonoCoat (Medi-Globe), coated by echogenic polymers made by Encapson...
September 2016: Gastrointestinal Endoscopy
Peter L Bonate, Malidi Ahamadi, Nageshwar Budha, Amparo de la Peña, Justin C Earp, Ying Hong, Mats O Karlsson, Patanjali Ravva, Ana Ruiz-Garcia, Herbert Struemper, Janet R Wade
The purpose of this work was to present a consolidated set of guidelines for the analysis of uncontrolled concomitant medications (ConMed) as a covariate and potential perpetrator in population pharmacokinetic (PopPK) analyses. This white paper is the result of an industry-academia-regulatory collaboration. It is the recommendation of the working group that greater focus be given to the analysis of uncontrolled ConMeds as part of a PopPK analysis of Phase 2/3 data to ensure that the resulting outcome in the PopPK analysis can be viewed as reliable...
April 2016: Journal of Pharmacokinetics and Pharmacodynamics
M E Pogarasteanu, A G Barbilian
Prosthetics is a modern area of interest and a challenge in Orthopedics. Over time, there has been a transition from an artisanal method of prosthetics production to modern concepts and materials, including a re-education through virtual reality. The conditions for an efficient fitting of a prosthesis include the necessity that the prosthesis respects the form and function of the lost limb, both anatomically and biomechanically. Prosthetics are made individually, personalized according to sex, age, physiological characteristics, profession and preference...
October 2014: Journal of Medicine and Life
Á A García-Ruano, F Najarro-Cid, A Jiménez-Martín, J G Gómez de los Infantes-Troncoso, M Sicre-González
INTRODUCTION AND OBJECTIVE: Lesions of triangular fibrocartilage (TFC) are associated with distal radioulnar joint instability. Arthroscopic treatment of these lesions improves functional outcome of affected patients. The aim of the present work is to evaluate functional and occupational outcome of TCF repair using an arthroscopic knotless anchor device in patients with associated distal radius fracture. MATERIAL AND METHODS: An observational, descriptive study was carried out between November 2011 and January 2014 including 21 patients with distal radius fracture and Palmer 1B lesions of TCF (Atzei class 2 and 3) that were treated by arthroscopic knotless anchor (PopLok® 2,8mm, ConMed, USA)...
July 2015: Revista Española de Cirugía Ortopédica y Traumatología
Alfred Papali, Ashutosh Sachdeva, Edward Pickering, Nirav Shah
SESSION TITLE: Bronchology/Interventional Global Case ReportsSESSION TYPE: Global Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Kaposi sarcoma (KS) remains the most common AIDS-associated neoplasm. Endobronchial KS typically appears as slightly raised, violaceous lesions in the sub-mucosa of the endobronchial wall and is usually associated with similar mucocutaneous lesions elsewhere on the body. We herein describe an unusual case of KS presenting as an isolated obstructing endobronchial tumor that was effectively resected using electrocautery snare and argon plasma coagulation (APC)...
October 1, 2014: Chest
Wei-Ren Su, Florence Y Ling, Chih-Kai Hong, Chih-Hsun Chang, Cheng-Li Lin, I-Ming Jou
UNLABELLED: There are several options for LHB tenodesis; yet, there is no standard of care. This technical note describes an extramedullary all-suture anchor technique for LHB tenodesis that is similar to the extramedullary cortical button technique. The LHB tenodesis is performed by using the Y-Knot (1.3-mm; ConMed Linvatec, Largo, FL).The biceps tenotomy is completed arthroscopically, and a standard subpectoral approach is used for the tenodesis. A reamer is first used to drill through the anterior cortex of the humerus; subsequently, a 1...
February 2015: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Bruno A M Rocha, Claudener S Teixeira, José C Silva-Filho, Raphael B Nóbrega, Daniel B Alencar, Kyria S Nascimento, Valder N Freire, Carmem J S Gottfried, Celso S Nagano, Alexandre H Sampaio, Silvana Saker-Sampaio, Benildo S Cavada, Plínio Delatorre
Resveratrol can also inhibit the activation of proinflammatory mediators and cytokines at the early gene expression stage. It is well known that lectins are sugar-binding proteins that act as both pro- and anti-inflammatory molecules. Thus, the objective of this work was to verify the binding of a polyphenol compound with a lectin of Canavalia maritima (ConM) based on their ability to inhibit pro-inflammatory processes. To accomplish this, ConM was purified and crystallized, and resveratrol was soaked at 5mM for 2h of incubation...
January 2015: International Journal of Biological Macromolecules
S Mugaba, R Nakiboneka, M Nanyonjo, D Bugembe-Lule, I Kaddu, B Nanteza, R Tweyongyere, P Kaleebu, J Serwanga
OBJECTIVE: Evaluating HIV-1 specific T-cell response in African populations is sometimes compromised by extensive virus diversity and paucity of non-clade B reagents. We evaluated whether consensus group M (ConM) peptides could serve as comparable substitutes for detecting immune responses in clade A and clade D HIV-1 infection. METHODS: Frequencies, breadths and polyfunctionality (≥ 3 functions: IFN-γ, IL-2, TNF-α and Perforin) of HIV-specific responses utilizing ConM, ConA and ConD Gag and Nef peptides was compared...
June 24, 2014: Vaccine
Nilson Vieira Pinto, Cláudia Ferreira Santos, Benildo Sousa Cavada, Kyria Santiago do Nascimento, Francisco Nascimento Pereira Junior, Alana de Freitas Pires, Ana Maria Sampaio Assreuy
Canavalia gladiata (CGL), C. maritima (ConM) and C. brasiliensis (ConBr) lectins were evaluated in nociception models. ConBr inhibited first (32%) and second (100%) phases of the formalin test; CGL inhibited only the first (74%) and ConM only the second (59%) phase. Hypernociception evaluated in the Von Frey test was inhibited by ConM (55%), CGL (41%) and ConBr (38%). Acetic acid-induced abdominal writhing was reduced by ConBr (66%), CGL (52%) and ConM (60%). ConBr and CGL effects were reversed by the lectin association with its ligand sugar...
November 2013: Natural Product Communications
James D Cezo, Anna C Passernig, Virginia L Ferguson, Kenneth D Taylor, Mark E Rentschler
Tissue fusion is a growing area of medical research that enables mechanical closure of tissues without the need of foreign bodies such as sutures or staples. Utilizing heat and pressure applied for a specified time, a bond can be formed between adjacent tissues. The success or failure of tissue fusion is contingent upon the strength of the bond it creates between opposing tissues, yet little characterization has been done to measure the strength of this interface as a function of the input parameters, such as heat and pressure...
February 2014: Journal of the Mechanical Behavior of Biomedical Materials
Tim Dwyer, Thomas L Willett, Andrew P Dold, Massimo Petrera, David Wasserstein, Danny B Whelan, John S Theodoropoulos
PURPOSE: The purpose of this study was to evaluate the biomechanical behavior of an all-suture glenoid anchor in comparison with a more conventional screw-in glenoid anchor, with regard to maximum load to failure and tensile displacement. METHODS: All mechanical testing was performed using an Instron ElectroPuls E1000 mechanical machine, with a 10 N pre-load and displacement rate of 10 mm/min. Force-displacement curves were generated, with calculation of maximum load, maximum displacement, displacement at 50 N and stiffness...
February 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
M H Baums, Ch Sachs, T Kostuj, K Schmidt-Horlohé, W Schultz, H-M Klinger
PURPOSE: This laboratory study aimed to evaluate the loop security, knot security, cyclic loading resistance and load-to-failure rate of three different knot types with establishing a new experimental set-up. Additionally, the mode of failure of each knot was evaluated. METHODS: With the use of nonabsorbable, braided polyethylene sutures, USP size No. 2 [Hi-Fi(®); ConMed Linvatec], the arthroscopic knot types Dines, SMC as well as the surgeon's knot were tested using a material testing machine...
October 13, 2013: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Adriana Martinez, Yung Han, Zeeshan M Sardar, Lorne Beckman, Thomas Steffen, Bruce S Miller, Paul A Martineau
PURPOSE: To examine the risk of glove tears associated with arthroscopic knot tying using 4 commonly used high-tensile strength sutures and 2 different types of gloves. METHODS: We analyzed 2 different surgical latex glove types (0.24-mm-thick powder-free and 0.32-mm-thick powdered) for perforation after arthroscopic knot tying with 4 different high-tensile strength sutures: Hi-Fi (ConMed Linvatec, Largo, FL), Ultrabraid (Smith & Nephew, Memphis, TN), FiberWire (Arthrex, Naples, FL), and Orthocord (DePuy Mitek, Raynham, MA)...
September 2013: Arthroscopy: the Journal of Arthroscopic & related Surgery
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