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https://www.readbyqxmd.com/read/28645892/meis1-effects-on-motor-phenotypes-and-the-sensorimotor-system-in-mice
#1
Aaro V Salminen, Lillian Garrett, Barbara Schormair, Jan Rozman, Florian Giesert, Kristina M Niedermeier, Lore Becker, Birgit Rathkolb, Ildikó Rácz, Martin Klingenspor, Thomas Klopstock, Eckhard Wolf, Andreas Zimmer, Valérie Gailus-Durner, Miguel Torres, Helmut Fuchs, Martin Hrabě de Angelis, Wolfgang Wurst, Sabine M Hölter, Juliane Winkelmann
MEIS1 is a developmental transcription factor linked to restless legs syndrome (RLS) in genome-wide association studies. RLS is a movement disorder leading to severe sleep reduction and with significant impact on the quality-of-life of patients. In genome-wide association studies, MEIS1 has consistently been the gene with the highest effect size and functional studies suggest a disease-relevant downregulation. Therefore, haploinsufficiency of Meis1 could be the most potential system for modeling RLS in animals...
June 23, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28642674/an-automatic-3d-ct-pet-segmentation-framework-for-bone-marrow-proliferation-assessment
#2
Chuong Nguyen, Joseph Havlicek, Quyen Duong, Sara Vesely, Ronald Gress, Liza Lindenberg, Peter Choyke, Jennifer Holter Chakrabarty, Kirsten Williams
Clinical assessment of bone marrow is limited by an inability to evaluate the marrow space comprehensively and dynamically and there is no current method for automatically assessing hematopoietic activity within the medullary space. Evaluating the hematopoietic space in its entirety could be applicable in blood disorders, malignancies, infections, and medication toxicity. In this paper, we introduce a CT/PET 3D automatic framework for measurement of the hematopoietic compartment proliferation within osseous sites...
September 2016: Proceedings
https://www.readbyqxmd.com/read/28640756/single-lead-f-wave-extraction-using-diffusion-geometry
#3
John Malik, Neil Reed, Chun-Li Wang, Hau-Tieng Wu
OBJECTIVE: A novel single-lead f-wave extraction algorithm based on the modern diffusion geometry data analysis framework is proposed. APPROACH: The algorithm is essentially an averaged beat subtraction algorithm, where the ventricular activity template is estimated by combining a newly designed metric, the 'diffusion distance', and the non-local Euclidean median based on the non-linear manifold setup. We coined the algorithm [Formula: see text]. MAIN RESULTS: Two simulation schemes are considered, and the new algorithm [Formula: see text] outperforms traditional algorithms, including the average beat subtraction, principal component analysis, and adaptive singular value cancellation, in different evaluation metrics with statistical significance...
June 22, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28636519/how-we-eat-may-be-as-important-as-what-we-eat-eating-behaviour-and-heart-rate-variability
#4
Mehmet Emre Ozpelit, Ebru Ozpelit
Objective Diet exerts a crucial role on cardiovascular health. Evidence is mainly based on the content and the amount of dietary intakes. Some recent reports demonstrated that eating behaviour may also be of significant importance in cardiovascular health. In this study we aimed to investigate the effects of eating behaviour on heart rate variability (HRV) in healthy subjects. Methods and results In total, 521 healthy subjects with 24-hour Holter ECG recordings filled out a special questionnaire about their eating behaviour and lifestyles...
March 30, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28629374/multi-purpose-ecg-telemetry-system
#5
Mohamed Marouf, Goran Vukomanovic, Lazar Saranovac, Miroslav Bozic
BACKGROUND: The Electrocardiogram ECG is one of the most important non-invasive tools for cardiac diseases diagnosis. Taking advantage of the developed telecommunication infrastructure, several approaches that address the development of telemetry cardiac devices were introduced recently. Telemetry ECG devices allow easy and fast ECG monitoring of patients with suspected cardiac issues. Choosing the right device with the desired working mode, signal quality, and the device cost are still the main obstacles to massive usage of these devices...
June 19, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28627418/alterations-in-neuronal-control-of-body-weight-and-anxiety-behavior-by-glutathione-peroxidase-4-deficiency
#6
Sonja C Schriever, Annemarie Zimprich, Katrin Pfuhlmann, Peter Baumann, Florian Giesert, Valentina Klaus, Dhiraj G Kabra, Ulrich Hafen, Artem Romanov, Matthias H Tschöp, Wolfgang Wurst, Marcus Conrad, Sabine M Hölter, Daniela Vogt Weisenhorn, Paul T Pfluger
Elevated levels of oxidative stress and neuronal inflammation in the hypothalamus or ventral midbrain, respectively, represent common denominators for obesity and Parkinson's Disease (PD). However, little is known about defense mechanisms that protect neurons in these regions from oxidative damage. Here, we aimed to assess whether murine Gpx4, a crucial antioxidant enzyme that protects neurons from membrane damage and ferroptosis, is critical for the protection from neuronal inflammation in two distinct pathophysiologic diseases, namely metabolic dysfunction in diet-induced obesity or PD...
June 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28626854/spatial-indices-of-repolarization-correlate-with-non-st-elevation-myocardial-ischemia-in-patients-with-chest-pain
#7
Salah Al-Zaiti, Ervin Sejdić, Jan Nemec, Clifton Callaway, Prem Soman, Robert Lux
Mild-to-moderate ischemia does not result in ST segment elevation on the electrocardiogram (ECG), but rather non-specific changes in the T wave, which are frequently labeled as non-diagnostic for ischemia. Robust methods to quantify such T wave heterogeneity can have immediate clinical applications. We sought to evaluate the effects of spontaneous ischemia on the evolution of spatial T wave changes, based on the eigenvalues of the spatial correlation matrix of the ECG, in patients undergoing nuclear cardiac imaging for evaluating intermittent chest pain...
June 19, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28624331/long-term-detection-of-atrial-fibrillation-with-insertable-cardiac-monitors-in-a-real-world-cryptogenic-stroke-population
#8
Paul D Ziegler, John D Rogers, Scott W Ferreira, Allan J Nichols, Mark Richards, Jodi L Koehler, Shantanu Sarkar
BACKGROUND: The long-term incidence of atrial fibrillation (AF) in cryptogenic stroke (CS) patients has been explored in carefully controlled clinical trials but real-world data are limited. We investigated the two-year incidence of AF in real-world clinical practice among a large cohort of patients with an insertable cardiac monitor (ICM) placed for AF detection following CS. METHODS: Patients in the de-identified Medtronic Discovery™ Link database who received an ICM (Reveal LINQ™) for the purpose of AF detection following CS were included and monitored for up to 2years...
June 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28623144/cardiovascular-stress-during-inpatient-spinal-cord-injury-rehabilitation
#9
Dominik Zbogar, Janice J Eng, William C Miller, Andrei V Krassioukov, Mary C Verrier
OBJECTIVES: 1) To measure the amount of a) cardiovascular stress, b) self-reported physical activity and c) accelerometry-measured physical activity by individuals with SCI during physical therapy (PT) and occupational therapy (OT) and, 2) to investigate the relationship between these measures. DESIGN: Observational study. SETTING: Two inpatient SCI rehabilitation centres. PARTICIPANTS: SCI patients (n=87) were recruited from consecutive admissions to rehabilitation...
June 13, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28621884/young-athletes-with-ventricular-premature-beats-continuing-or-not-intense-training-and-competition
#10
Attilio Parisi, Eliana Tranchita, Carlo Minganti, Fabio Sperandii, Emanuele Guerra, Leonardo Calò, Paolo Borrione, Fabio Pigozzi
INTRODUCTION: Isolated ventricular premature beats (VPBs) are commonly found during pre-participation screening in athletes. Currently the debate about the role of detraining in reducing the number of VPBs is still open. This study evaluated the arrhythmic risk in a population of young competitive athletes who showed VPBs during eligibility evaluation and that did not undergo detraining but continued practicing competitive sports. METHODS: 3746 consecutive subjects underwent pre-participation screening...
June 16, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28618169/ecg-derived-cheyne-stokes-respiration-and-periodic-breathing-in-healthy-and-hospitalized-populations
#11
Adelita Tinoco, Barbara J Drew, Xiao Hu, David Mortara, Bruce A Cooper, Michele M Pelter
BACKGROUND: Cheyne-Stokes respiration (CSR) has been investigated primarily in outpatients with heart failure. In this study we compare CSR and periodic breathing (PB) between healthy and cardiac groups. METHODS: We compared CSR and PB, measured during 24 hr of continuous 12-lead electrocardiographic (ECG) Holter recording, in a group of 90 hospitalized patients presenting to the emergency department with symptoms suggestive of acute coronary syndrome (ACS) to a group of 100 healthy ambulatory participants...
June 15, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28617967/holter-monitored-sudden-cardiac-arrest-after-atrioventricular-junction-ablation
#12
Victor Waldmann, Eloi Marijon, Nicolas Combes
We present a case of sudden cardiac arrest seven hours after radiofrequency ablation of the atrioventricular junction for symptomatic permanent atrial fibrillation unresponsive to medical therapy. The Holter monitoring revealed a progressive increasing of QT interval after the procedure, highlighting the repolarization instability after acute changes in heart rates associated with modification of ventricular activation, leading to occurrence of short coupling interval ventricular extra beats and finally to a "Torsade de Pointes"...
June 15, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28612913/the-usefulness-of-soluble-st2-and-galectin-3-as-novel-biomarkers-for-better-risk-stratification-in-hypertrophic-cardiomyopathy
#13
Monika Gawor, Mateusz Śpiewak, Jadwiga Janas, Katarzyna Kożuch, Aleksandra Wróbel, Łukasz Mazurkiewicz, Rafał Baranowski, Magdalena Marczak, Jacek Grzybowski
BACKGROUND: Estimation of sudden cardiac death (SCD) risk is an integral part of clinical management of patients with hypertrophic cardiomyopathy (HCM). Identification of novel biomarkers of this disease can provide additional criteria for SCD risk stratification. Soluble suppression of tumorigenicity (sST2) and galectin-3 (Gal-3) are useful biomarkers for prognosis of heart failure (HF). Both of them appear to mediate cardiac fibrosis - an important pathogenetic process in HCM. Data about sST2 and Gal-3 usefulness in patients with HCM are limited...
June 14, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28597737/extension-of-catheter-ablation-and-outcome-for-ventricular-tachycardia-or-premature-ventricular-contractions-from-the-right-ventricular-outflow-tract
#14
Ki-Hun Kim, Hyoung-Seob Park, Yeo-Jung Song, Jeong-Sook Seo, Han-Young Jin, Dae-Kyeong Kim, Dong-Soo Kim, Young-Soo Lee, Ki-Won Hwang, Guang-Won Seo, Dong-Kie Kim, Pil-Sang Song, Sang-Hoon Seol, Doo-Il Kim, Yoon-Nyun Kim
Objective We aimed to determine whether the extension of ablation could influence the ablation outcome for ventricular tachycardia (VT)/premature ventricular contractions (PVCs) from the right ventricular outflow tract (RVOT). Methods and results The radiofrequency catheter ablation results of 33 VT/6 frequent PVCs from the RVOT were analysed. The ablation extension was divided into 3 categories from the final successful ablation point with the earliest activation: (I) focal ablation (15 cases); ablation at 1 or 2 points; (II) focal with extended ablation (12 cases); focal and surrounding area ablation (maximum ≤1 cm) after elimination of clinical VT/PVCs; and (III) broad ablation (12 cases); continued broad ablation (maximum >1 cm) after elimination of clinical VT/PVCs...
February 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28595215/case-image-the-moment-of-return-from-the-edge-of-death-holter-ecg-recording-in-a-patient-with-syncope
#15
Yalçın Velibey, Ahmet İlker Tekkeşin, Göksel Çinier, Özge Güzelburç, Ahmet Taha Alper
No abstract text is available yet for this article.
June 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28590366/effect-of-gwas-identified-genetic-variants-on-maximum-qt-interval-in-patients-with-schizophrenia-receiving-antipsychotic-agents-a-24-hour-holter-ecg-study
#16
Junzo Watanabe, Naoki Fukui, Yutaro Suzuki, Takuro Sugai, Shin Ono, Nobuto Tsuneyama, Mami Saito, Misuzu Tajiri, Toshiyuki Someya
BACKGROUND: Users of antipsychotics (APs) have a risk of sudden cardiac death (SCD). Sudden cardiac death in such patients is thought to be largely due to drug-induced QT prolongation. It has been reported that many subjects with drug-induced torsades de pointes (TdP) have risk alleles associated with subclinical congenital long QT syndrome. METHODS: We investigated the effects of the risk alleles associated with long QT on the QT interval in patients receiving APs using 24-hour Holter electrocardiograms to take into account the circadian fluctuation of QT intervals...
June 5, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28586628/effectiveness-of-radial-extracorporeal-shock-wave-therapy-reswt-when-combined-with-supervised-exercises-in-patients-with-subacromial-shoulder-pain-a-double-masked-randomized-sham-controlled-trial
#17
Elisabeth Kvalvaag, Jens Ivar Brox, Kaia Beck Engebretsen, Helene Lundgaard Soberg, Niels Gunnar Juel, Erik Bautz-Holter, Leiv Sandvik, Cecilie Roe
BACKGROUND: Subacromial shoulder pain is a common complaint, and radial extracorporeal shock wave therapy (rESWT) is increasingly used to treat this condition. Although many therapists use rESWT in combination with supervised exercises, no studies have evaluated the additional effect of rESWT with supervised exercises for subacromial shoulder pain. PURPOSE: To assess whether rESWT is more effective than sham rESWT when combined with supervised exercises for improving pain and function in patients with subacromial shoulder pain...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28581287/electrochemical-detection-of-ultratrace-picomolar-levels-of-hg-2-using-a-silver-nanoparticle-modified-glassy-carbon-electrode
#18
Alex L Suherman, Kamonwad Ngamchuea, Eden E L Tanner, Stanislav V Sokolov, Jennifer Holter, Neil P Young, Richard G Compton
Ultratrace levels of Hg(2+) have been quantified by undertaking linear sweep voltammetry with a silver nanoparticle-modified glassy carbon electrode (AgNP-GCE) in aqueous solutions containing Hg(2+). This is achieved by monitoring the change in the silver stripping peak with Hg(2+) concentration resulting from the galvanic displacement of silver by mercury: Ag(np) + 1/2Hg(2+)(aq) → Ag(+)(aq) + 1/2Hg(l). This facile and reproducible detection method exhibits an excellent linear dynamic range of 100.0 pM to 10...
June 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28580152/brugada-phenocopy-in-a-patient-with-acute-pulmonary-embolism-presenting-with-recurrent-syncope
#19
Nixiao Zhang, Tong Liu, Gary Tse, Shuyu Yu, Huaying Fu, Gang Xu, Changyu Zhou, Chengzong Zhang, Guangping Li
Brugada phenocopy (BrP) refers to a group of clinical conditions that have etiologies distinct from Brugada syndrome (BrS). Although both demonstrate features of ST-segment elevation in the right precordial leads on the electrocardiogram (ECG), one must be distinguished from the other as their treatment options are different. We report a male patient who presented with recurrent syncope with a Brugada and a S1Q3T3 pattern on the ECG. Acute pulmonary embolism (APE) complicated by BrS was suspected. Twenty-four hours Holter monitoring did not demonstrate any evidence of ventricular arrhythmias...
May 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28576855/sodium-balance-circadian-bp-rhythm-heart-rate-variability-and-intrarenal-renin-angiotensin-aldosterone-and-dopaminergic-systems-in-acute-phase-of-arb-therapy
#20
Yukako Isobe-Sasaki, Michio Fukuda, Yoshiaki Ogiyama, Ryo Sato, Toshiyuki Miura, Daisuke Fuwa, Masashi Mizuno, Tetsuhei Matsuoka, Hiroko Shibata, Hiroyuki Ito, Minamo Ono, Sumiko Abe-Dohmae, Ken Kiyono, Yoshiharu Yamamoto, Hiroyuki Kobori, Makoto Michikawa, Junichiro Hayano, Nobuyuki Ohte
We have revealed that even in humans, activated intrarenal renin-angiotensin-aldosterone system (RAAS) enhances tubular sodium reabsorption to facilitate salt sensitivity and nondipper rhythm of blood pressure (BP), and that angiotensin receptor blocker (ARB) could increase daytime urinary sodium excretion rate (UNaV) to produce lower sodium balance and restore nondipper rhythm. However, the sympathetic nervous system and intrarenal dopaminergic system can also contribute to renal sodium handling. A total of 20 patients with chronic kidney disease (61 ± 15 years) underwent 24-h ambulatory BP monitoring before and during two-day treatment with ARB, azilsartan...
June 2017: Physiological Reports
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