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Neutrophil imaging

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https://www.readbyqxmd.com/read/28318437/case-240-meckel-diverticulitis
#1
R Ashley Milam, Ricardo B Fonseca
History A previously healthy 28-year-old man developed right lower quadrant pain while traveling. The pain progressed over the course of 2-3 days, and his family took him to a local emergency department. He was found to have an elevated white blood cell count of 12.2 × 10(9)/L (reference range, [3.9-10.3] × 10(9)/L), with a predominance of neutrophils. Contrast material-enhanced computed tomography (CT) of the abdomen and pelvis was performed, and findings were abnormal. The patient elected to leave the emergency department without undergoing treatment, and he returned home via airplane...
April 2017: Radiology
https://www.readbyqxmd.com/read/28303065/bilateral-lacrimal-caruncle-lesions
#2
Yuta Okumura, Yoshiko Takai, Shunsuke Yasuda, Hiroko Terasaki
A 65-year-old man was referred to our hospital for the treatment of a lesion on the medial lacrimal canthus of both eyes. He had a history of perinuclear anti-neutrophil cytoplasmic antibodies, i.e., pANCA-positive interstitial pneumonia. Orbital magnetic resonance imaging excluded space occupying lesions, and laboratory testing excluded thyroid-related diseases. The masses were excised, and histopathological examinations showed sebaceous gland hyperplasia and inflammatory changes around the gland. In addition, the specimen from the left eye showed a retention cyst possibly caused by an infection...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28294319/grpr-antagonist-protects-from-drug-induced-liver-injury-by-impairing-neutrophil-chemotaxis-and-motility
#3
Rafael S Czepielewski, Natália Jaeger, Pedro E Marques, Maísa M Antunes, Maurício M Rigo, Débora M Alvarenga, Rafaela V Pereira, Rodrigo D da Silva, Tiago G Lopes, Vinícius D da Silva, Bárbara N Porto, Gustavo B Menezes, Cristina Bonorino
Drug-induced liver injury (DILI) is a major cause of acute liver failure (ALF), where hepatocyte necrotic products trigger liver inflammation, release of CXCR2 ligands (IL-8) and other neutrophil chemotactic molecules. Liver infiltration by neutrophils is a major cause of the life threatening tissue damage that ensues. A GRPR (gastrin-releasing peptide receptor) antagonist impairs IL-8-induced neutrophil chemotaxis in vitro. We investigated its potential to reduce acetaminophen-induced ALF, neutrophil migration and mechanisms underlying this phenomenon...
March 10, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28289416/specific-and-efficient-uptake-of-surfactant-free-poly-lactic-acid-nanovaccine-vehicles-by-mucosal-dendritic-cells-in-adult-zebrafish-after-bath-immersion
#4
Julien Rességuier, Emilie Delaune, Anne-Line Coolen, Jean-Pierre Levraud, Pierre Boudinot, Dominique Le Guellec, Bernard Verrier
Activation of mucosal immunity is a key milestone for next-generation vaccine development. Biocompatible polymer-based nanoparticles (NPs) are promising vectors and adjuvants for mucosal vaccination. However, their in vivo uptake by mucosae and their biodistribution in antigen-presenting cells (APCs) need to be better understood to optimize mucosal nanovaccine designs. Here, we assessed if APCs are efficiently targeted in a spontaneous manner by surfactant-free poly(lactic acid) nanoparticles (PLA-NPs) after mucosal administration...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28259750/long-term-outcomes-of-salvage-stereotactic-ablation-radiotherapy-for-isolated-lung-recurrence-of-non-small-cell-lung-cancer-a-phase-ii-clinical-trial
#5
Bing Sun, Eric D Brooks, Ritsuko Komaki, Zhongxing Liao, Melenda Jeter, Mary McAleer, Peter A Balter, James D Welsh, Michael O'Reilly, Daniel Gomez, Stephen M Hahn, Boris Sepesi, David C Rice, John V Heymach, Joe Y Chang
OBJECTIVES: Our goal was to evaluate stereotactic ablative radiotherapy (SABR) as a salvage option for isolated recurrence of non-small-cell lung cancer (NSCLC) in the lung parenchyma following definitive treatment of stage I-III disease. METHODS: Patients who had histologically confirmed, positron emission tomography (PET) staged, isolated NSCLC recurring locally or metastasis in the lung parenchyma (≤3 cm, suitable for SABR) after previous definitive treatment, were prospectively enrolled in this trial and treated with volumetric, image-guided SABR to 50 Gy in four fractions...
March 1, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28246361/new-mouse-model-for-chronic-infections-by-gram-negative-bacteria-enabling-the-study-of-anti-infective-efficacy-and-host-microbe-interactions
#6
Daniel Pletzer, Sarah C Mansour, Kelli Wuerth, Negin Rahanjam, Robert E W Hancock
Only a few, relatively cumbersome animal models enable long-term Gram-negative bacterial infections that mimic human situations, where untreated infections can last for weeks. Here, we describe a simple murine cutaneous abscess model that enables chronic or progressive infections, depending on the subcutaneously injected bacterial strain. In this model, Pseudomonas aeruginosa cystic fibrosis epidemic isolate LESB58 caused localized high-density skin and soft tissue infections and necrotic skin lesions for up to 10 days but did not disseminate in either CD-1 or C57BL/6 mice...
February 28, 2017: MBio
https://www.readbyqxmd.com/read/28237630/-18-f-fluoro-2-deoxyglucose-pet-informs-neutrophil-accumulation-and-activation-in-lipopolysaccharide-induced-acute-lung-injury
#7
Rosana S Rodrigues, Fernando A Bozza, Christopher J Hanrahan, Li-Ming Wang, Qi Wu, John M Hoffman, Guy A Zimmerman, Kathryn A Morton
INTRODUCTION: Molecular imaging of the earliest events related to the development of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) could facilitate therapeutic development and patient management. We previously reported that (18)F-fluoro-2-deoxyglucose ((18)F-FDG) PET identifies ALI/ARDS prior to radiographic abnormalities. The purpose of this study was to establish the time courses of (18)F-FDG uptake, edema and neutrophil recruitment in an endotoxin-induced acute lung injury model and to examine molecular events required for (14)C-2DG uptake in activated neutrophils...
January 17, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28213094/aspirin-triggered-resolvin-d1-modified-materials-promote-the-accumulation-of-pro-regenerative-immune-cell-subsets-and-enhance-vascular-remodeling
#8
Mary Caitlin P Sok, Maxianne C Tria, Claire E Olingy, Cheryl L San Emeterio, Edward A Botchwey
Many goals in tissue engineering rely on modulating cellular localization and polarization of cell signaling, including the inhibition of inflammatory infiltrate, facilitation of inflammatory cell egress, and clearance of apoptotic cells. Omega-3 polyunsaturated fatty acid-derived resolvins are gaining increasing recognition for their essential roles in inhibition of neutrophil invasion into inflamed tissue and promotion of macrophage phagocytosis of cellular debris as well as their egress to the lymphatics...
February 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28205623/preventive-effects-of-carnosine-on-lipopolysaccharide-induced-lung-injury
#9
Ken-Ichiro Tanaka, Toshifumi Sugizaki, Yuki Kanda, Fumiya Tamura, Tomomi Niino, Masahiro Kawahara
Acute respiratory distress syndrome (ARDS) is a potentially devastating form of acute lung injury, which involves neutrophilic inflammation and pulmonary cell death. Reactive oxygen species (ROS) play important roles in ARDS development. New compounds for inhibiting the onset and progression of ARDS are required. Carnosine (β-alanyl-L-histidine) is a small di-peptide with numerous activities, including antioxidant effects, metal chelation, proton buffering capacity and the inhibition of protein carbonylation and glycoxidation...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28191879/visualizing-the-early-stages-of-phagocytosis
#10
Ali Rashidfarrokhi, Veronica Richina, Fikadu G Tafesse
The mammalian body is equipped with various layers of mechanisms that help to defend itself from pathogen invasions. Professional phagocytes of the immune system - such as neutrophils, dendritic cells, and macrophages - retain the innate ability to detect and clear such invading pathogens through phagocytosis(1). Phagocytosis involves choreographed events of membrane reorganization and actin remodeling at the cell surface(2)(,)(3). Phagocytes successfully internalize and eradicate foreign molecules only when all stages of phagocytosis are fulfilled...
February 3, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28190710/neutrophil-to-lymphocyte-ratio-predicts-disease-progression-following-intra-arterial-therapy-of-hepatocellular-carcinoma
#11
Matthew D Taussig, Mary Ellen Irene Koran, Samdeep K Mouli, Asma Ahmad, Sunil Geevarghese, Jennifer C Baker, Andrew J Lipnik, Fil Banovac, Daniel B Brown
BACKGROUND: Prospectively predicting response to intra-arterial therapy for hepatocellular carcinoma (HCC) is challenging. Neutrophil/lymphocyte ratio (NLR) is a serum biomarker that is associated with survival for multiple malignancies. It was hypothesized that increased NLR would be associated with early disease progression after intra-arterial therapy of HCC. METHODS: The outcomes of 86 treatment-naïve patients who had chemoembolization or radioembolization of HCC between July 2013-July 2014 were reviewed...
February 9, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28163299/a-rare-case-of-acute-phlegmonous-esophagogastritis-complicated-with-hypopharyngeal-abscess-and-esophageal-perforation
#12
Yuan-Chun Huang, Ching-Yuan Cheng, Chiung-Ying Liao, Ching Hsueh, Yeu-Sheng Tyan, Shang-Yun Ho
BACKGROUND Acute phlegmonous esophagogastritis is a life-threatening disease that may be combined with serious complications. We present the classical radiological and endoscopic features and treatment strategy of a middle-aged female patient suffering from acute phlegmonous esophagogastritis complicated with hypopharyngeal abscess, esophageal perforation, mediastinitis, and empyema. CASE REPORT A 60-year-old Taiwanese female presented at our hospital due to fever, fatigue, painful swallowing, and vague chest pain for 5 days...
February 6, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28162159/-the-value-of-different-antibodies-detection-in-diagnosis-of-rheumatism-with-uveitis
#13
X F Xu, J Zhang, L Cui, Y H Wang, Y Yue, L Chi, J Bai, H M Li, X X Lu
Objective: To investigate the value of HLA-B27 antigen, antinuclear antibody (ANA), anti-dsDNA and Anti-Neutrophil Cytoplasmic Antibodies (ANCA) detection in diagnosis of rheumatism with uveitis. Methods: Seven hundred and twenty four newly diagnosed patients with non-infection uveitis in Beijing Tongren Hospital from March 2012 to March 2016 who long-term lived in Beijing and its surrounding areas were continuously enrolled. HLA-B27 antigen expressions in peripheral blood lymphocytes and ANA, anti-dsDNA and ANCA levels in serum were tested...
January 24, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28159748/estradiol-promotes-breast-cancer-cell-migration-via-recruitment-and-activation-of-neutrophils
#14
Gabriela Vazquez Rodriguez, Annelie Abrahamsson, Lasse Dahl Ejby Jensen, Charlotta Dabrosin
Estradiol (E2) plays a key role in breast cancer progression. Most breast cancer recurrences express the estrogen receptor (ER), but nearly 50% of patients are resistant to antiestrogen therapy. Novel therapeutic targets of ER-positive breast cancers are needed. Protumoral neutrophils expressing the lymphocyte function-associated antigen 1 (LFA-1) integrin may mediate cancer metastasis, and TGFβ1 is the major chemoattractant for neutrophils. The role of E2 in neutrophil-ER(+) breast cancer cell interactions is unknown...
February 3, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28143694/quantitative-computed-tomographic-imaging-based-clustering-differentiates-asthmatic-subgroups-with-distinctive-clinical-phenotypes
#15
Sanghun Choi, Eric A Hoffman, Sally E Wenzel, Mario Castro, Sean Fain, Nizar Jarjour, Mark L Schiebler, Kun Chen, Ching-Long Lin
BACKGROUND: Imaging variables, including airway diameter, wall thickness, and air trapping, have been found to be important metrics when differentiating patients with severe asthma from those with nonsevere asthma and healthy subjects. OBJECTIVE: The objective of this study was to identify imaging-based clusters and to explore the association of the clusters with existing clinical metrics. METHODS: We performed an imaging-based cluster analysis using quantitative computed tomography-based structural and functional variables extracted from the respective inspiration and expiration scans of 248 asthmatic patients...
January 29, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28138440/inverse-correlation-between-cd8-inflammatory-cells-and-e-cadherin-expression-in-gallbladder-cancer-tissue-microarray-and-imaging-analysis
#16
Keita Kai, Masanori Masuda, Shinichi Aishima
AIM: To investigated the association between the tumor cells' expression of E-cadherin and the numbers of several types of inflammatory cells infiltrating into the invasive portion of gallbladder cancer (GBC). METHODS: We analyzed 50 GBC cases for which a sufficient amount of tumor tissues for tissue microarray (TMA) had been saved. Three tissue cores (3.0 mm) of invasive lesion from each case were used for the TMA. The 4-μm cut sections on slides were immunostained using primary antibodies including E-cadherin for cancer cells, leukocyte common antigen for leukocyte, myeloperoxidase for neutrophils, CD3 for T cells, CD4 for helper T cells, CD8 for killer T cells, CD20 for B cells and CD68 for macrophages...
January 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28129850/innate-immune-cells-and-bacterial-infection-in-zebrafish
#17
J W Astin, P Keerthisinghe, L Du, L E Sanderson, K E Crosier, P S Crosier, C J Hall
The physical attributes of the zebrafish, including optical transparency during embryogenesis, large clutch sizes, external development, and rapid organogenesis were features that initially attracted developmental biologists to use this vertebrate as an experimental model system. With the progressive development of an extensive genetic "tool kit" and an ever-growing number of transgenic reporter lines, the zebrafish model has evolved into an informative system in which to mimic and study aspects of human disease, including those associated with bacterial infections...
2017: Methods in Cell Biology
https://www.readbyqxmd.com/read/28119899/superficial-angiomyxoma-of-the-vulva-in-a-postmenopausal-woman-a-case-report-and-review-of-literature
#18
Seung Hyun Lee, Yeon Jean Cho, Myoungseok Han, Jong Woon Bae, Jung-Woo Park, So Ra Oh, Sujin Kim
Superficial angiomyxomas (SAMs) are rare benign cutaneous tumors that involve the subcutaneous layer. They are commonly located in the trunk, lower limbs and head or neck of women of reproductive age. SAMs in the vulva of postmenopausal women are especially rare case. Herein, we report a vulvar SAM in a postmenopausal 60-year-old woman. The patient presented with a palpable cutaneous mass in the right labium majora that had appeared 3 months earlier. The mass was slow growing and approximately 5 cm in size and resembled a soft tissue malignancy...
December 2016: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/28115509/the-tat-substrate-sufi-is-critical-for-the-ability-of-yersinia-pseudotuberculosis-to-cause-systemic-infection
#19
Ummehan Avican, Tugrul Doruk, Yngve Östberg, Anna Fahlgren, Åke Forsberg
The Twin-arginine translocation (Tat) system targets folded proteins across the inner membrane and it is crucial for virulence in many important human pathogenic bacteria. Tat has been shown to be required for virulence of Yersinia pseudotuberculosis and we recently showed that the system is critical for different virulence related stress responses as well as for iron uptake. In this study, we wanted to address the role of the Tat substrates in in vivo virulence. Therefore, 22 genes encoding potential Tat substrates were mutated and each mutant was evaluated in competitive oral infection of mice...
January 23, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28105976/early-subretinal-allograft-rejection-is-characterized-by-innate-immune-activity
#20
Kevin P Kennelly, Toby M Holmes, Deborah M Wallace, Cliona O'Farrelly, David J Keegan
<p>Successful subretinal transplantation is limited by considerable early graft loss, despite pharmacological suppression of adaptive immunity. We postulated that early innate immune activity is a dominant factor in determining graft survival and chose a non-immunosuppressed mouse model of retinal pigment epithelial (RPE) cell transplantation to explore this.</p><p>Expression of almost all measured cytokines by DH01 RPE cells increased significantly following graft preparation and the neutrophil chemoattractant, KC/GRO/CINC, was most significantly increased...
January 20, 2017: Cell Transplantation
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