keyword
MENU ▼
Read by QxMD icon Read
search

Macrophage pet

keyword
https://www.readbyqxmd.com/read/29729443/positron-emission-tomography-pet-and-single-photon-emission-computed-tomography-spect-imaging-of-macrophages-in-large-vessel-vasculitis-current-status-and-future-prospects
#1
REVIEW
William Febry Jiemy, Peter Heeringa, Jan A A M Kamps, Conny J van der Laken, Riemer H J A Slart, Elisabeth Brouwer
Macrophages are key players in the pathogenesis of large-vessel vasculitis (LVV) and may serve as a target for diagnostic imaging of LVV. The radiotracer, 18 F-FDG has proven to be useful in the diagnosis of giant cell arteritis (GCA), a form of LVV. Although uptake of 18 F-FDG is high in activated macrophages, it is not a specific radiotracer as its uptake is high in any proliferating cell and other activated immune cells resulting in high non-specific background radioactivity especially in aging and atherosclerotic vessels which dramatically lowers the diagnostic accuracy...
May 2, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29721153/application-of-polymersomes-engineered-to-target-p32-protein-for-detection-of-small-breast-tumors-in-mice
#2
Lorena Simón-Gracia, Pablo Scodeller, Sergio Salazar Fuentes, Vanessa Gómez Vallejo, Xabier Ríos, Eneko San Sebastián, Valeria Sidorenko, Desirè Di Silvio, Meina Suck, Federica De Lorenzi, Larissa Yokota Rizzo, Saskia von Stillfried, Kalle Kilk, Twan Lammers, Sergio E Moya, Tambet Teesalu
Triple negative breast cancer (TNBC) is the deadliest form of breast cancer and its successful treatment critically depends on early diagnosis and therapy. The multi-compartment protein p32 is overexpressed and present at cell surfaces in a variety of tumors, including TNBC, specifically in the malignant cells and endothelial cells, and in macrophages localized in hypoxic areas of the tumor. Herein we used polyethylene glycol-polycaprolactone polymersomes that were affinity targeted with the p32-binding tumor penetrating peptide LinTT1 (AKRGARSTA) for imaging of TNBC lesions...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29700689/imaging-inflammation-in-atherosclerotic-plaques-just-make-it-easy
#3
EDITORIAL
Fabien Hyafil, Jonathan Vigne
The presence of inflammatory cells is a hallmark of unstable atherosclerotic plaques. Several imaging approaches have been developed for the noninvasive detection of inflammatory activities in atherosclerotic plaques. Positron emission tomography (PET) imaging with the injection of 18F-fluorodeoxyglucose (FDG) is currently the most widely used imaging technique to evaluate the density of activated macrophages in atherosclerotic plaques. Nevertheless, FDG-PET imaging has logistical and technical constraints that represent an important obstacle to the wider use of this approach for the evaluation of patients with atherosclerosis...
April 26, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29700124/biodistribution-and-radiation-dosimetry-of-124-i-iodo-dpa-713-a-pet-radiotracer-for-macrophage-associated-inflammation
#4
Catherine A Foss, Donika Plyku, Alvaro A Ordonez, Julian Sanchez-Bautista, Hailey B Rosenthal, I L Minn, Martin A Lodge, Martin G Pomper, George Sgouros, Sanjay K Jain
Whole body PET/CT imaging was performed using 124 I-iodo-DPA-713, a radioligand for the 18-kDa translocator protein (TSPO), to determine biodistribution and radiation dosimetry. METHODS: Healthy subjects ages 18-65 years underwent whole body PET/CT imaging at either 4, 24 and 48 hours or 24, 48 and 72 hours after intravenous injection with 124 I-iodo-DPA-713. Time-activity curves were generated and used to calculate organ time-integrated activity coefficients for each subject. The resulting time-integrated activity coefficients provided input data for calculation of organ absorbed doses and effective dose for each subject using OLINDA...
April 26, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29681783/imaging-and-methotrexate-response-monitoring-of-systemic-inflammation-in-arthritic-rats-employing-the-macrophage-pet-tracer-18-f-fluoro-peg-folate
#5
Durga M S H Chandrupatla, Gerrit Jansen, Elise Mantel, Philip S Low, Takami Matsuyama, René P Musters, Albert D Windhorst, Adriaan A Lammertsma, Carla F M Molthoff, Conny J van der Laken
Background: In rheumatoid arthritis, articular inflammation is a hallmark of disease, while the involvement of extra-articular tissues is less well defined. Here, we examined the feasibility of PET imaging with the macrophage tracer [18 F]fluoro-PEG-folate, targeting folate receptor β (FR β ), to monitor systemic inflammatory disease in liver and spleen of arthritic rats before and after methotrexate (MTX) treatment. Methods: [18 F]Fluoro-PEG-folate PET scans (60 min) were acquired in saline- and MTX-treated (1 mg/kg, 4x) arthritic rats, followed by tissue resection and radiotracer distribution analysis...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29603831/an-autopsy-case-report-differences-in-radiological-images-correlate-with-histology-in-erdheim-chester-disease
#6
Yuuki Ohara, Seiichi Kato, Daisuke Yamashita, Akira Satou, Yoshie Shimoyama, Chie Hamaie, Motoki Sato, Nobutaro Ban, Koji Yamamoto, Takehiro Yamada, Hisashi Kawai, Koichi Ohshima, Shigeo Nakamura, Shinya Toyokuni
p16 activation caused by oncogenic mutations may represent oncogene-induced senescence (OIS), a protective mechanism against oncogenic events. However, OIS can contribute to tumor development via tissue remodeling in some tumors. Erdheim-Chester disease (ECD), a rare non-Langerhans cell histiocytosis, is one such tumor. Its clinical and histological features vary, making it difficult to diagnose. Herein, we describe an autopsy of an ECD patient. The patient underwent radiological examinations, including18 F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT), bone scintigraphy and CT...
March 30, 2018: Pathology International
https://www.readbyqxmd.com/read/29567678/visualization-of-monocytic-cells-in-regressing-atherosclerotic-plaques-by-intravital-2-photon-and-positron-emission-tomography-based-imaging
#7
Wenjun Li, Hannah P Luehmann, Hsi-Min Hsiao, Satona Tanaka, Ryuiji Higashikubo, Jason M Gauthier, Deborah Sultan, Kory J Lavine, Steven L Brody, Andrew E Gelman, Robert J Gropler, Yongjian Liu, Daniel Kreisel
OBJECTIVE: Aortic arch transplants have advanced our understanding of processes that contribute to progression and regression of atherosclerotic plaques. To characterize the dynamic behavior of monocytes and macrophages in atherosclerotic plaques over time, we developed a new model of cervical aortic arch transplantation in mice that is amenable to intravital imaging. APPROACH AND RESULTS: Vascularized aortic arch grafts were transplanted heterotropically to the right carotid arteries of recipient mice using microsurgical suture techniques...
March 22, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29523925/tspo-pet-with-18-f-ge-180-sensitively-detects-focal-neuroinflammation-in-patients-with-relapsing-remitting-multiple-sclerosis
#8
Marcus Unterrainer, C Mahler, L Vomacka, S Lindner, J Havla, M Brendel, G Böning, B Ertl-Wagner, T Kümpfel, V M Milenkovic, R Rupprecht, M Kerschensteiner, P Bartenstein, Nathalie L Albert
PURPOSE: Expression of the translocator protein (TSPO) is upregulated in activated macrophages/microglia and is considered to be a marker of neuroinflammation. We investigated the novel TSPO ligand [18 F]GE-180 in patients with relapsing-remitting multiple sclerosis (RRMS) to determine the feasibility of [18 F]GE-180 PET imaging in RRMS patients and to assess its ability to detect active inflammatory lesions in comparison with the current gold standard, contrast-enhanced magnetic resonance imaging (MRI)...
March 9, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29511843/pet-assessment-of-immune-cell-activity-and-therapeutic-monitoring-following-myocardial-infarction
#9
REVIEW
James T Thackeray
PURPOSE OF REVIEW: Local inflammation after myocardial infarction (MI) plays a role in subsequent ventricular remodeling, influences cardiac outcome, and has emerged as a therapeutic target. Preclinical and clinical PET imaging studies have employed a variety of radiotracers to target inflammatory leukocytes in the early stages after MI. RECENT FINDINGS: Imaging of enhanced metabolism in activated macrophages with 18 F-FDG is feasible and has been associated with cardiac outcome in a small prospective study...
March 6, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29485431/fdg-pet-ct-findings-of-erdheim-chester-disease-radiologic-response-to-a-novel-treatment-regimen
#10
Esma A Akin, Murat Osman, Amy L Ellenbogen
Erdheim-Chester disease (ECD) is a rare form of non-Langerhans histiocytosis with deposition of lipid-laden macrophages in numerous organs. A 74-year-old man with a history of coronary artery disease, hypertension, and hyperlipidemia presented with nonspecific symptoms including back pain, nausea, vomiting, vertigo, and left leg pain. A neutrophil-predominant elevated WBC count and a bone biopsy revealing histiocytic proliferation positive for CD68 and CD163 and negative for S100 was noted. FDG PET/CT, MRA, and CTA images were obtained...
May 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29435774/pet-molecular-targets-and-near-infrared-fluorescence-imaging-of-atherosclerosis
#11
REVIEW
Csilla Celeng, Bart de Keizer, Béla Merkely, Pim de Jong, Tim Leiner, Richard A P Takx
PURPOSE OF REVIEW: With this review, we aim to summarize the role of positron emission tomography (PET) and near-infrared fluorescence imaging (NIRF) in the detection of atherosclerosis. RECENT FINDINGS: 18 F-FDG is an established measure of increased macrophage activity. However, due to its low specificity, new radiotracers have emerged for more specific detection of vascular inflammation and other high-risk plaque features such as microcalcification and neovascularization...
February 12, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29435154/efficacy-of-granulocyte-macrophage-colony-stimulating-factor-combined-with-metronomic-paclitaxel-in-the-treatment-of-lewis-lung-carcinoma-transplanted-in-mice
#12
Nengping Zhu, Rongsheng Qin, Qin Zhang, Shaozhi Fu, Shanshan Liu, Yue Chen, Juan Fan, Yunwei Han
Metronomic chemotherapy in combination with immunotherapy is an attractive approach in cancer therapy. The purpose of the present study was to investigate the anti-tumor effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) in combination with metronomic paclitaxel (MET PTX) on Lewis lung carcinoma transplanted in mice. In the present study, tumor-bearing mice survival time and tumor growth were monitored. The day after the end of the treatment, white blood cells were counted, and the number and maturation of dendritic cell were determined by flow cytometry...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29428948/ratio-of-immune-response-to-tumor-burden-predicts-survival-via-regulating-functions-of-lymphocytes-and-monocytes-in-diffuse-large-b-cell-lymphoma
#13
Hongfei Ji, Xingjian Niu, Lei Yin, Yiran Wang, Lan Huang, Qijia Xuan, Liru Li, Han Zhang, Jingtong Li, Yue Yang, Weiwei An, Qingyuan Zhang
BACKGROUND/AIMS: Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease, and is the most common type of lymphoma in adults. Although significant progress in treatment has been made using chemotherapy combinations, there exist a large amount of relapse or refractory cases. Thus, effective clinical biomarkers for DLBCL are urgently needed. Our study aims to explore the predictive significance of using the immune response to tumor burden ratio [defined as the lymphocyte to monocyte ratio (LMR)/lactate dehydrogenase (LDH) levels] in 184 DLBCL patients and the potential mechanism underlying the use of the LMR to tumor burden ratio in predicting patient survival...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29413439/combined-pet-dce-mri-in-a-rabbit-model-of-atherosclerosis-integrated-quantification-of-plaque-inflammation-permeability-and-burden-during-treatment-with-a-leukotriene-a4-hydrolase-inhibitor
#14
Claudia Calcagno, Olivier Lairez, Julie Hawkins, Steven W Kerr, Melanie S Dugas, Thomas Simpson, Jelle Epskamp, Philip M Robson, Mootaz Eldib, Ilda Bander, Purushothaman K-Raman, Sarayu Ramachandran, Alison Pruzan, Audrey Kaufman, Venkatesh Mani, Alexander Ehlgen, Heiko G Niessen, John Broadwater, Zahi A Fayad
OBJECTIVES: The authors sought to develop combined positron emission tomography (PET) dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) to quantify plaque inflammation, permeability, and burden to evaluate the efficacy of a leukotriene A4 hydrolase (LTA4H) inhibitor in a rabbit model of atherosclerosis. BACKGROUND: Multimodality PET/MRI allows combining the quantification of atherosclerotic plaque inflammation, neovascularization, permeability, and burden by combined 18 F-fluorodeoxyglucose (18 F-FDG) PET, DCE-MRI, and morphological MRI...
February 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29390877/adipose-derived-mesenchymal-stromal-cells-improve-the-healing-of-colonic-anastomoses-following-high-dose-of-irradiation-through-anti-inflammatory-and-angiogenic-processes
#15
Dirk Van de Putte, Christelle Demarquay, Elke Van Daele, Lara Moussa, Christian Vanhove, Marc Benderitter, Wim Ceelen, Piet Pattyn, Noëlle Mathieu
Cancer patients treated with radiotherapy (RT) could develop severe late side effects that affect their quality of life. Long-term bowel complications after RT are mainly characterized by a transmural fibrosis that could lead to intestinal obstruction. Today, surgical resection is the only effective treatment. However, preoperative RT increases the risk of anastomotic leakage. In this study, we attempted to use mesenchymal stromal cells from adipose tissue (Ad-MSCs) to improve colonic anastomosis after high-dose irradiation...
December 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29348018/myocardial-inflammation-predicts-remodeling-and-neuroinflammation-after-myocardial-infarction
#16
James T Thackeray, Henri C Hupe, Yong Wang, Jens P Bankstahl, Georg Berding, Tobias L Ross, Johann Bauersachs, Kai C Wollert, Frank M Bengel
BACKGROUND: The local inflammatory tissue response after acute myocardial infarction (MI) determines subsequent healing. Systemic interaction may induce neuroinflammation as a precursor to neurodegeneration. OBJECTIVES: This study sought to assess the influence of MI on cardiac and brain inflammation using noninvasive positron emission tomography (PET) of the heart-brain axis. METHODS: After coronary artery ligation or sham surgery, mice (n = 49) underwent serial whole-body PET imaging of the mitochondrial translocator protein (TSPO) as a marker of activated macrophages and microglia...
January 23, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29339450/cardiac-macrophages-promote-diastolic-dysfunction
#17
Maarten Hulsmans, Hendrik B Sager, Jason D Roh, María Valero-Muñoz, Nicholas E Houstis, Yoshiko Iwamoto, Yuan Sun, Richard M Wilson, Gregory Wojtkiewicz, Benoit Tricot, Michael T Osborne, Judy Hung, Claudio Vinegoni, Kamila Naxerova, David E Sosnovik, Michael R Zile, Amy D Bradshaw, Ronglih Liao, Ahmed Tawakol, Ralph Weissleder, Anthony Rosenzweig, Filip K Swirski, Flora Sam, Matthias Nahrendorf
Macrophages populate the healthy myocardium and, depending on their phenotype, may contribute to tissue homeostasis or disease. Their origin and role in diastolic dysfunction, a hallmark of cardiac aging and heart failure with preserved ejection fraction, remain unclear. Here we show that cardiac macrophages expand in humans and mice with diastolic dysfunction, which in mice was induced by either hypertension or advanced age. A higher murine myocardial macrophage density results from monocyte recruitment and increased hematopoiesis in bone marrow and spleen...
February 5, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29326355/-18-f-fedac-as-a-targeting-agent-for-activated-macrophages-in-dba-1-mice-with-collagen-induced-arthritis-comparison-with-18-f-fdg
#18
Seock-Jin Chung, Hai-Jeon Yoon, Gi Jeong Cheon, Hyewon Youn, Mi Jeong Kim, Lin Xie, Yun-Sang Lee, Jae Min Jeong, June-Key Chung, Keon Wook Kang, Ming-Rong Zhang
Activated macrophages have been known to play pivotal roles in the pathogenesis of rheumatoid arthritis (RA). 18 F-FEDAC is a radiolabeled ligand for the translocator protein (TSPO), which is abundant in activated macrophages. We evaluated the feasibility of 18 F-FEDAC in a murine RA model. Methods: RAW 264.7 mouse macrophages were activated by lipopolysaccharide. TSPO expression levels in activated and inactivated macrophages were measured by quantitative polymerase chain reaction (qPCR) and western blotting...
January 11, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29301931/translocator-protein-as-an-imaging-marker-of-macrophage-and-stromal-activation-in-ra-pannus
#19
Nehal Narayan, David Owen, Harpreet Mandhair, Erica Smyth, Francesco Carlucci, Azeem Saleem, Roger Gunn, Eugenii Ilan A Rabiner, Lisa Wells, Stephanie Dakin, Afsie Sabokbar, Peter Taylor
Positron Emission Tomography (PET) radioligands targeted to Translocator protein (TSPO), offer a highly sensitive and specific means of imaging joint inflammation in rheumatoid arthritis (RA). Through high expression of TSPO on activated macrophages, TSPO PET has been widely reported in several studies of RA as a means of imaging synovial macrophages in vivo. However, this premise does not take into account the ubiquitous expression of TSPO. This study aimed to investigate TSPO expression in major cellular constituents of RA pannus; monocytes, macrophages, fibroblast-like synoviocytes (FLS) and CD4+ T lymphocytes, to more accurately interpret TSPO PET signal from RA synovium...
January 4, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29297157/astroglial-responses-to-amyloid-beta-progression-in-a-mouse-model-of-alzheimer-s-disease
#20
Malin Olsen, Ximena Aguilar, Dag Sehlin, Xiaotian T Fang, Gunnar Antoni, Anna Erlandsson, Stina Syvänen
PURPOSE: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by amyloid-beta (Aβ) deposition, hyperphosphorylation of tau, and neuroinflammation. Astrocytes, the most abundant glial cell type in the nervous system, respond to neurodegenerative disorders through astrogliosis, i.e., converting to a reactive inflammatory state. The aim of this study was to investigate how in vivo quantification of astrogliosis using positron emission tomography (PET) radioligand deuterium-L-[11 C]deprenyl ([11 C]DED), binding to enzyme monoamine oxidase-B (MAO-B) which is overexpressed in reactive astrocytes during AD, corresponds to expression of glial fibrillary acidic protein (GFAP) and vimentin, i...
January 2, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
keyword
keyword
53541
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"