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https://www.readbyqxmd.com/read/29778944/activation-and-blockade-of-basolateral-amygdala-5-ht-6-receptor-produce-anxiolytic-like-behaviors-in-an-experimental-model-of-parkinson-s-disease
#1
Yi-Na Sun, Lu Yao, Li-Bo Li, Yong Wang, Cheng-Xue Du, Yuan Guo, Jian Liu
Although the basolateral amygdala (BLA) and serotonin6 (5-HT6 ) receptor are involved in modulation of anxiety, their roles in Parkinson' disease (PD)-related anxiety are still unknown. Thus we perform this study to examine the involvement of BLA 5-HT6 receptor on anxiety in unilateral 6-hydroxydopamine-induced PD rats. The lesion of the medial forebrain bundle (MFB) induced anxiety-like behaviors, and decreased the basal firing rate of BLA glutamate neurons and dopamine (DA) levels in tissues of the medial prefrontal cortex (mPFC), amygdala and ventral part of hippocampus (vHip) in rats...
May 17, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29661608/modafinil-alleviates-levodopa-induced-excessive-nighttime-sleepiness-and-restores-monoaminergic-systems-in-a-nocturnal-animal-model-of-parkinson-s-disease
#2
Rina Ando, Mohammed Emamussalehin Choudhury, Yuki Yamanishi, Win Thiri Kyaw, Madoka Kubo, Mariko Kannou, Noriko Nishikawa, Junya Tanaka, Masahiro Nomoto, Masahiro Nagai
Treatment with dopaminergic agents result excessive daytime sleepiness (EDS) and some studies have shown the benefit of using modafinil for treating excessive daytime sleepiness of Parkinson's disease (PD) patient. We investigated whether modafinil have ameliorative properties against levodopa induced excessive nighttime sleepiness (ENS) in MPTP-treated murine nocturnal PD model. Our EEG analyses of whole day recordings revealed that modafinil reduce ENS of this nocturnal PD models with levodopa medications...
March 31, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29615861/lead-induced-atypical-parkinsonism-in-rats-behavioral-electrophysiological-and-neurochemical-evidence-for-a-role-of-noradrenaline-depletion
#3
Mariam Sabbar, Claire Delaville, Philippe De Deurwaerdère, Nouria Lakhdar-Ghazal, Abdelhamid Benazzouz
Background: Lead neurotoxicity is a major health problem known as a risk factor for neurodegenerative diseases, including the manifestation of parkinsonism-like disorder. While lead is known to preferentially accumulate in basal ganglia, the mechanisms underlying behavioral disorders remain unknown. Here, we investigated the neurophysiological and biochemical correlates of motor deficits induced by sub-chronic injections of lead. Methods: Sprague Dawely rats were exposed to sub-chronic injections of lead (10 mg/kg, i...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29605442/intranasal-administration-of-sodium-dimethyldithiocarbamate-induces-motor-deficits-and-dopaminergic-dysfunction-in-mice
#4
Josiel M Mack, Tainara M Moura, Débora Lanznaster, Franciane Bobinski, Caio M Massari, Tuane B Sampaio, Ariana E Schmitz, Luiz F Souza, Roger Walz, Carla I Tasca, Anicleto Poli, Richard L Doty, Alcir L Dafre, Rui D Prediger
The primary etiology of Parkinson's disease (PD) remains unclear, but likely reflects a combination of genetic and environmental factors. Exposure to some pesticides, including ziram (zinc dimethyldithiocarbamate), is a relevant risk factor for PD. Like some other environmental neurotoxicants, we hypothesized that ziram can enter the central nervous system from the nasal mucosa via the olfactory nerves. To address this issue, we evaluated the effects of 1, 2 or 4 days of intranasal (i.n., 1 mg/nostril/day) infusions of sodium dimethyldithiocarbamate (NaDMDC), a dimethyldithiocarbamate more soluble than ziram, on locomotor activity in the open field, neurological severity score and rotarod performance...
March 29, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29552632/cerebrospinal-fluid-and-serum-mhpg-improve-alzheimer-s-disease-versus-dementia-with-lewy-bodies-differential-diagnosis
#5
Jana Janssens, Yannick Vermeiren, Erik Fransen, Tony Aerts, Debby Van Dam, Sebastiaan Engelborghs, Peter P De Deyn
Introduction: Given the challenges concerning the differential diagnosis of dementia, we investigated the possible added value of monoaminergic compounds to the standard cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers. Particularly, regarding the AD versus dementia with Lewy bodies (DLB) comparison, monoamines or their metabolites might have added discriminative value as there is a more severe neuropathological burden in the locus coeruleus of DLB patients, the principal site of noradrenaline synthesis...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29480224/monoaminergic-markers-across-the-cognitive-spectrum-of-lewy-body-disease
#6
Sygrid van der Zee, Yannick Vermeiren, Erik Fransen, Debby Van Dam, Tony Aerts, Marleen J Gerritsen, Jacoba M Spikman, Teus van Laar, Peter P De Deyn
BACKGROUND: Lewy body disorders, including Parkinson's disease (PD), Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB), are characterized by profound central and peripheral monoaminergic dysfunction. OBJECTIVE: To investigate whether these alterations depend on dementia status, we measured cerebrospinal fluid (CSF) and serum monoamine and metabolite levels across subgroups of the cognitive spectrum, and evaluated their marker potential afterwards...
2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29421436/dopamine-noradrenaline-and-serotonin-receptor-densities-in-the-striatum-of-hemiparkinsonian-rats-following-botulinum-neurotoxin-a-injection
#7
T Mann, K Zilles, H Dikow, A Hellfritsch, M Cremer, M Piel, F Rösch, A Hawlitschka, O Schmitt, A Wree
Parkinson's disease (PD) is characterized by a degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) that causes a dopamine (DA) deficit in the caudate-putamen (CPu) accompanied by compensatory changes in other neurotransmitter systems. These changes result in severe motor and non-motor symptoms. To disclose the role of various receptor binding sites for DA, noradrenaline, and serotonin in the hemiparkinsonian (hemi-PD) rat model induced by unilateral 6-hydroxydopamine (6-OHDA) injection, the densities of D1 , D2 /D3 , α1 , α2 , and 5HT2A receptors were longitudinally visualized and measured in the CPu of hemi-PD rats by quantitative in vitro receptor autoradiography...
March 15, 2018: Neuroscience
https://www.readbyqxmd.com/read/29339319/treatment-with-the-noradrenaline-re-uptake-inhibitor-atomoxetine-alone-and-in-combination-with-the-%C3%AE-2-adrenoceptor-antagonist-idazoxan-attenuates-loss-of-dopamine-and-associated-motor-deficits-in-the-lps-inflammatory-rat-model-of-parkinson-s-disease
#8
Justin D Yssel, Eoin O'Neill, Yvonne M Nolan, Thomas J Connor, Andrew Harkin
The impact of treatment with the noradrenaline (NA) re-uptake inhibitor atomoxetine and the α2 -adrenoceptor (AR) antagonist idazoxan in an animal model of Parkinson's disease (PD) was assessed. Concurrent systemic treatment with atomoxetine and idazoxan, a combination which serves to enhance the extra-synaptic availability of NA, exerts anti-inflammatory and neuroprotective effects following delivery of an inflammatory stimulus, the bacterial endotoxin, lipopolysaccharide (LPS) into the substantia nigra. Lesion-induced deficits in motor function (akinesia, forelimb-use asymmetry) and striatal dopamine (DA) loss were rescued to varying degrees depending on the treatment...
March 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29220864/the-nature-of-catecholamine-containing-neurons-in-the-enteric-nervous-system-in-relationship-with-organogenesis-normal-human-anatomy-and-neurodegeneration
#9
G Natale, L Ryskalin, C L Busceti, F Biagioni, F Fornai
The gastrointestinal tract is provided with extrinsic and intrinsic innervation. The extrinsic innervation includes the classic vagal parasympathetic and sympathetic components, with afferent sensitive and efferent secretomotor fibers. The intrinsic innervations is represented by the enteric nervous system (ENS), which is recognized as a complex neural network controlling a variety of cell populations, including smooth muscle cells, mucosal secretory cells, endocrine cells, microvasculature, immune and inflammatory cells...
September 1, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/29111577/applications-of-acupuncture-therapy-in-modulating-plasticity-of-central-nervous-system
#10
REVIEW
Ling-Yong Xiao, Xue-Rui Wang, Ye Yang, Jing-Wen Yang, Yan Cao, Si-Ming Ma, Tian-Ran Li, Cun-Zhi Liu
OBJECTIVE: Acupuncture is widely applied for treatment of various neurological disorders. This manuscript will review the preclinical evidence of acupuncture in mediating neural plasticity, the mechanisms involved. MATERIALS AND METHODS: We searched acupuncture, plasticity, and other potential related words at the following sites: PubMed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), and VIP information data base. The following keywords were used: acupuncture, electroacupuncture, plasticity, neural plasticity, neuroplasticity, neurogenesis, neuroblast, stem cell, progenitor cell, BrdU, synapse, synapse structure, synaptogenesis, axon, axon regeneration, synaptic plasticity, LTP, LTD, neurotrophin, neurotrophic factor, BDNF, GDNF, VEGF, bFGF, EGF, NT-3, NT-4, NT-5, p75NTR, neurotransmitter, acetylcholine, norepinephrine, noradrenaline, dopamine, monamine...
November 7, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29108985/serotonergic-neurons-mediate-the-anxiolytic-effect-of-l-dopa-neuronal-correlates-in-the-amygdala
#11
Emilie Faggiani, Frederic Naudet, Marcus L F Janssen, Yasin Temel, Abdelhamid Benazzouz
Anxiety in Parkinson's disease is a comorbid non-motor symptom that alters the quality of life of patients. Its neuronal substrates and those of l-Dopa treatment are still poorly known. Using different combinations of monoaminergic system lesions in the rat, we addressed the contribution of these systems in the efficacy of l-DOPA on anxiety and on the neuronal activity of basolateral amygdala (BLA), a brain structure involved in anxiety. Anxiety, locomotor activity and motor performance were assessed using the elevated plus maze, the open field and the skinner box, respectively...
February 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29016861/dj-1-is-a-redox-sensitive-adapter-protein-for-high-molecular-weight-complexes-involved-in-regulation-of-catecholamine-homeostasis
#12
Dominik Piston, Lydia Alvarez-Erviti, Vikas Bansal, Daniela Gargano, Zhi Yao, Gyorgy Szabadkai, Mark Odell, M Rhyan Puno, Benny Björkblom, Jodi Maple-Grødem, Peter Breuer, Oliver Kaut, Jan Petter Larsen, Stefan Bonn, Simon Geir Møller, Ullrich Wüllner, Anthony H V Schapira, Matthew E Gegg
DJ-1 is an oxidation sensitive protein encoded by the PARK7 gene. Mutations in PARK7 are a rare cause of familial recessive Parkinson's disease (PD), but growing evidence suggests involvement of DJ-1 in idiopathic PD. The key clinical features of PD, rigidity and bradykinesia, result from neurotransmitter imbalance, particularly the catecholamines dopamine (DA) and noradrenaline. We report in human brain and human SH-SY5Y neuroblastoma cell lines that DJ-1 predominantly forms high molecular weight (HMW) complexes that included RNA metabolism proteins hnRNPA1 and PABP1 and the glycolysis enzyme GAPDH...
October 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29016795/leonurine-exerts-antidepressant-like-effects-in-the-chronic-mild-stress-induced-depression-model-in-mice-by-inhibiting-neuroinflammation
#13
Miaomiao Jia, Chenxin Li, Ying Zheng, Xiaojing Ding, Meng Chen, Jianhua Ding, Renhong Du, Ming Lu, Gang Hu
Background: Leonurine is an active alkaloid that is extracted from Traditional Chinese Medicine Herba leonuri. Emerging evidence indicates that leonurine produces neuroprotective effects in ischemic stroke, Parkinson's disease, and Alzheimer's disease. However, the effect of leonurine in neuropsychiatric disorders, especially in major depression, remains unknown. Methods: We used the chronic mild stress mouse model to explore the antidepressant effects of leonurine and the potential mechanisms...
November 1, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28843848/depressive-like-neurochemical-and-behavioral-markers-of-parkinson-s-disease-after-6-ohda-administered-unilaterally-to-the-rat-medial-forebrain-bundle
#14
Kinga Kamińska, Tomasz Lenda, Jolanta Konieczny, Anna Czarnecka, Elżbieta Lorenc-Koci
BACKGROUND: Although Parkinson's disease (PD) is characterized by progressive neurodegeneration of multiple neurotransmitter systems, 6-hydroxydopamine (6-OHDA) as a model substance is mainly used to selectively damage the nigrostriatal dopaminergic neurons and induce parkinsonian-like motor disturbances in rats. We hypothesized that high doses of this neurotoxin affecting other monoaminergic systems may also evoke the depressive-like behavior. METHODS: The impact of 6-OHDA (8, 12, 16μg/4μl) administered unilaterally into the medial forebrain bundle on the sucrose solution intake (a measure of anhedonia) and on the tissue levels of noradrenaline (NA), dopamine (DA) and serotonin (5-HT) in the striatum (STR), substantia nigra (SN), prefrontal cortex (PFC) and hippocampus (HIP) was examined in rats pretreated or non-pretreated with desipramine...
June 3, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28716399/prelimbic-%C3%AE-1-adrenoceptors-are-involved-in-the-regulation-of-depressive-like-behaviors-in-the-hemiparkinsonian-rats
#15
Zhong Heng Wu, Qiao Jun Zhang, Cheng Xue Du, Yue Xi, Wen Juan Li, Fang Yuan Guo, Shu Qi Yu, Ya Xin Yang, Jian Liu
At present, it is not clear whether α1-adrenoceptors in the prelimbic cortex (PrL) are involved in Parkinson's disease-related depression. Here we examined effects of PrL α1-adrenoceptors on depressive-like behaviors in rats with unilateral 6-hydroxydopamine lesions of the medial forebrain bundle. The lesion induced depressive-like responses as measured by the sucrose preference and forced swim tests compared to sham-operated rats. Intra-PrL injection of α1-adrenoceptor agonist phenylephrine induced or increased the expression of depressive-like behaviors in sham-operated and the lesioned rats...
July 14, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28611598/early-paradoxical-increase-of-dopamine-a-neurochemical-study-of-olfactory-bulb-in-asymptomatic-and-symptomatic-mptp-treated-monkeys
#16
Christian Pifl, Harald Reither, Natalia Lopez-Gonzalez Del Rey, Carmen Cavada, Jose A Obeso, Javier Blesa
Parkinson's disease (PD) is a neurodegenerative disease with both motor and non-motor manifestations. Hyposmia is one of the early non-motor symptoms, which can precede motor symptoms by several years. The relationship between hyposmia and PD remains elusive. Olfactory bulb (OB) pathology shows an increased number of olfactory dopaminergic cells, protein aggregates and dysfunction of neurotransmitter systems. In this study we examined tissue levels of dopamine (DA) and serotonin (5-hydroxytryptamine, 5-HT) and their metabolites, of noradrenaline (NA) and of the amino acid neurotransmitters aspartate, glutamate, taurine and γ-aminobutyric acid in OBs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated Macaca fascicularis in different stages, including monkeys who were always asymptomatic, monkeys who recovered from mild parkinsonian signs, and monkeys with stable moderate or severe parkinsonism...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28590911/effect-of-%C3%AE-ethyl-%C3%AE-phenyl-butyrolactone-efbl-anticonvulsant-and-hypnotic-drug-on-mouse-brain-catecholamine-levels
#17
Lourdes A Vega Rasgado, Iván Villanueva, Fernando Vega Díaz
γ-Ethyl-γ-phenyl-butyrolactone (EFBL) is a structural combination of the anticonvulsant γ-hydroxy-γ-ethyl-γ-phenylbutyramide (HEPB) and the hypnotic γ-butyrolactone (GBL), which inherits both properties. To clarify its mechanism of action, the effects of EFBL, GBL and HEPB on dopamine (DA) and noradrenaline (NA) brain levels were investigated. Influences of chlorpromazine, phenelzine and aminooxyacetic acid were also studied. EFBL increased DA in a dose-dependent manner, remaining enhanced by 80 % over a period of 24 h and augmented NA by 54 % one hour after treatment...
June 27, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28523903/dopamine-and-noradrenaline-but-not-serotonin-in-the-human-claustrum-are-greatly-reduced-in-patients-with-parkinson-s-disease-possible-functional-implications
#18
Harald H Sitte, Christian Pifl, Ali H Rajput, Heide Hörtnagl, Junchao Tong, George K Lloyd, Stephen J Kish, Oleh Hornykiewicz
No abstract text is available yet for this article.
May 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28520722/altered-detrusor-contractility-in-mptp-treated-common-marmosets-with-bladder-hyperreflexia
#19
Sara Pritchard, Michael J Jackson, Atsuko Hikima, Lisa Lione, Christopher D Benham, K Ray Chaudhuri, Sarah Rose, Peter Jenner, Mahmoud M Iravani
Bladder hyperreflexia is a common non-motor feature of Parkinson's disease. We now report on the contractility of the isolated primate detrusor strips devoid of nerve input and show that following MPTP, the amplitude and frequency of spontaneous contraction was increased. These responses were unaffected by dopamine D1 and D2 receptor agonists A77636 and ropinirole respectively. Contractions by exogenous carbachol, histamine or ATP were similar and no differences in the magnitude of noradrenaline-induced relaxation were seen in detrusor strip obtained from normal and MPTP-treated common marmosets (Callithrix jacchus)...
2017: PloS One
https://www.readbyqxmd.com/read/28460583/subchronic-low-level-intraperitoneal-injections-of-manganese-iv-oxide-and-manganese-ii-chloride-affect-rat-brain-neurochemistry
#20
Brian S Nielsen, Erik H Larsen, Ole Ladefoged, Henrik R Lam
Manganese (Mn) is neurotoxic and can induce manganism, a Parkinson-like disease categorized as being a serious central nervous system irreversible neurodegenerative disease. An increased risk of developing symptoms of Parkinson disease has been linked to work-related exposure, for example, for workers in agriculture, horticulture, and people living near areas with frequent use of Mn-containing pesticides. In this study, the focus was placed on neurochemical effects of Mn. Rats were dosed intraperitoneally with 0...
May 2017: International Journal of Toxicology
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