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https://www.readbyqxmd.com/read/29111577/applications-of-acupuncture-therapy-in-modulating-plasticity-of-central-nervous-system
#1
REVIEW
Ling-Yong Xiao, Xue-Rui Wang, Ye Yang, Jing-Wen Yang, Yan Cao, Si-Ming Ma, Tian-Ran Li, Cun-Zhi Liu
OBJECTIVE: Acupuncture is widely applied for treatment of various neurological disorders. This manuscript will review the preclinical evidence of acupuncture in mediating neural plasticity, the mechanisms involved. MATERIALS AND METHODS: We searched acupuncture, plasticity, and other potential related words at the following sites: PubMed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), and VIP information data base. The following keywords were used: acupuncture, electroacupuncture, plasticity, neural plasticity, neuroplasticity, neurogenesis, neuroblast, stem cell, progenitor cell, BrdU, synapse, synapse structure, synaptogenesis, axon, axon regeneration, synaptic plasticity, LTP, LTD, neurotrophin, neurotrophic factor, BDNF, GDNF, VEGF, bFGF, EGF, NT-3, NT-4, NT-5, p75NTR, neurotransmitter, acetylcholine, norepinephrine, noradrenaline, dopamine, monamine...
November 7, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29108985/serotonergic-neurons-mediate-the-anxiolytic-effect-of-l-dopa-neuronal-correlates-in-the-amygdala
#2
Emilie Faggiani, Frederic Naudet, Marcus L F Janssen, Yasin Temel, Abdelhamid Benazzouz
Anxiety in Parkinson's disease is a comorbid non-motor symptom that alters the quality of life of patients. Its neuronal substrates and those of l-Dopa treatment are still poorly known. Using different combinations of monoaminergic system lesions in the rat, we addressed the contribution of these systems in the efficacy of l-DOPA on anxiety and on the neuronal activity of basolateral amygdala (BLA), a brain structure involved in anxiety. Anxiety, locomotor activity and motor performance were assessed using the elevated plus maze, the open field and the skinner box, respectively...
November 3, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29016861/dj-1-is-a-redox-sensitive-adapter-protein-for-high-molecular-weight-complexes-involved-in-regulation-of-catecholamine-homeostasis
#3
Dominik Piston, Lydia Alvarez-Erviti, Vikas Bansal, Daniela Gargano, Zhi Yao, Gyorgy Szabadkai, Mark Odell, M Rhyan Puno, Benny Björkblom, Jodi Maple-Grødem, Peter Breuer, Oliver Kaut, Jan Petter Larsen, Stefan Bonn, Simon Geir Møller, Ullrich Wüllner, Anthony H V Schapira, Matthew E Gegg
DJ-1 is an oxidation sensitive protein encoded by the PARK7 gene. Mutations in PARK7 are a rare cause of familial recessive Parkinson's disease (PD), but growing evidence suggests involvement of DJ-1 in idiopathic PD. The key clinical features of PD, rigidity and bradykinesia, result from neurotransmitter imbalance, particularly the catecholamines dopamine (DA) and noradrenaline. We report in human brain and human SH-SY5Y neuroblastoma cell lines that DJ-1 predominantly forms high molecular weight (HMW) complexes that included RNA metabolism proteins hnRNPA1 and PABP1 and the glycolysis enzyme GAPDH...
October 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29016795/leonurine-exerts-antidepressant-like-effects-in-the-chronic-mild-stress-induced-depression-model-in-mice-by-inhibiting-neuroinflammation
#4
Miaomiao Jia, Chenxin Li, Ying Zheng, Xiaojing Ding, Meng Chen, Jianhua Ding, Renhong Du, Ming Lu, Gang Hu
Background: Leonurine is an active alkaloid that is extracted from Traditional Chinese Medicine Herba leonuri. Emerging evidence indicates that leonurine produces neuroprotective effects in ischemic stroke, Parkinson's disease, and Alzheimer's disease. However, the effect of leonurine in neuropsychiatric disorders, especially in major depression, remains unknown. Methods: We used the chronic mild stress mouse model to explore the antidepressant effects of leonurine and the potential mechanisms...
November 1, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28843848/depressive-like-neurochemical-and-behavioral-markers-of-parkinson-s-disease-after-6-ohda-administered-unilaterally-to-the-rat-medial-forebrain-bundle
#5
Kinga Kamińska, Tomasz Lenda, Jolanta Konieczny, Anna Czarnecka, Elżbieta Lorenc-Koci
BACKGROUND: Although Parkinson's disease (PD) is characterized by progressive neurodegeneration of multiple neurotransmitter systems, 6-hydroxydopamine (6-OHDA) as a model substance is mainly used to selectively damage the nigrostriatal dopaminergic neurons and induce parkinsonian-like motor disturbances in rats. We hypothesized that high doses of this neurotoxin affecting other monoaminergic systems may also evoke the depressive-like behavior. METHODS: The impact of 6-OHDA (8, 12, 16μg/4μl) administered unilaterally into the medial forebrain bundle on the sucrose solution intake (a measure of anhedonia) and on the tissue levels of noradrenaline (NA), dopamine (DA) and serotonin (5-HT) in the striatum (STR), substantia nigra (SN), prefrontal cortex (PFC) and hippocampus (HIP) was examined in rats pretreated or non-pretreated with desipramine...
June 3, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28716399/prelimbic-%C3%AE-1-adrenoceptors-are-involved-in-the-regulation-of-depressive-like-behaviors-in-the-hemiparkinsonian-rats
#6
Zhong Heng Wu, Qiao Jun Zhang, Cheng Xue Du, Yue Xi, Wen Juan Li, Fang Yuan Guo, Shu Qi Yu, Ya Xin Yang, Jian Liu
At present, it is not clear whether α1-adrenoceptors in the prelimbic cortex (PrL) are involved in Parkinson's disease-related depression. Here we examined effects of PrL α1-adrenoceptors on depressive-like behaviors in rats with unilateral 6-hydroxydopamine lesions of the medial forebrain bundle. The lesion induced depressive-like responses as measured by the sucrose preference and forced swim tests compared to sham-operated rats. Intra-PrL injection of α1-adrenoceptor agonist phenylephrine induced or increased the expression of depressive-like behaviors in sham-operated and the lesioned rats...
July 14, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28611598/early-paradoxical-increase-of-dopamine-a-neurochemical-study-of-olfactory-bulb-in-asymptomatic-and-symptomatic-mptp-treated-monkeys
#7
Christian Pifl, Harald Reither, Natalia Lopez-Gonzalez Del Rey, Carmen Cavada, Jose A Obeso, Javier Blesa
Parkinson's disease (PD) is a neurodegenerative disease with both motor and non-motor manifestations. Hyposmia is one of the early non-motor symptoms, which can precede motor symptoms by several years. The relationship between hyposmia and PD remains elusive. Olfactory bulb (OB) pathology shows an increased number of olfactory dopaminergic cells, protein aggregates and dysfunction of neurotransmitter systems. In this study we examined tissue levels of dopamine (DA) and serotonin (5-hydroxytryptamine, 5-HT) and their metabolites, of noradrenaline (NA) and of the amino acid neurotransmitters aspartate, glutamate, taurine and γ-aminobutyric acid in OBs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated Macaca fascicularis in different stages, including monkeys who were always asymptomatic, monkeys who recovered from mild parkinsonian signs, and monkeys with stable moderate or severe parkinsonism...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28590911/effect-of-%C3%AE-ethyl-%C3%AE-phenyl-butyrolactone-efbl-anticonvulsant-and-hypnotic-drug-on-mouse-brain-catecholamine-levels
#8
Lourdes A Vega Rasgado, Iván Villanueva, Fernando Vega Díaz
γ-Ethyl-γ-phenyl-butyrolactone (EFBL) is a structural combination of the anticonvulsant γ-hydroxy-γ-ethyl-γ-phenylbutyramide (HEPB) and the hypnotic γ-butyrolactone (GBL), which inherits both properties. To clarify its mechanism of action, the effects of EFBL, GBL and HEPB on dopamine (DA) and noradrenaline (NA) brain levels were investigated. Influences of chlorpromazine, phenelzine and aminooxyacetic acid were also studied. EFBL increased DA in a dose-dependent manner, remaining enhanced by 80 % over a period of 24 h and augmented NA by 54 % one hour after treatment...
June 27, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28523903/dopamine-and-noradrenaline-but-not-serotonin-in-the-human-claustrum-are-greatly-reduced-in-patients-with-parkinson-s-disease-possible-functional-implications
#9
Harald H Sitte, Christian Pifl, Ali H Rajput, Heide Hörtnagl, Junchao Tong, George K Lloyd, Stephen J Kish, Oleh Hornykiewicz
No abstract text is available yet for this article.
May 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28520722/altered-detrusor-contractility-in-mptp-treated-common-marmosets-with-bladder-hyperreflexia
#10
Sara Pritchard, Michael J Jackson, Atsuko Hikima, Lisa Lione, Christopher D Benham, K Ray Chaudhuri, Sarah Rose, Peter Jenner, Mahmoud M Iravani
Bladder hyperreflexia is a common non-motor feature of Parkinson's disease. We now report on the contractility of the isolated primate detrusor strips devoid of nerve input and show that following MPTP, the amplitude and frequency of spontaneous contraction was increased. These responses were unaffected by dopamine D1 and D2 receptor agonists A77636 and ropinirole respectively. Contractions by exogenous carbachol, histamine or ATP were similar and no differences in the magnitude of noradrenaline-induced relaxation were seen in detrusor strip obtained from normal and MPTP-treated common marmosets (Callithrix jacchus)...
2017: PloS One
https://www.readbyqxmd.com/read/28460583/subchronic-low-level-intraperitoneal-injections-of-manganese-iv-oxide-and-manganese-ii-chloride-affect-rat-brain-neurochemistry
#11
Brian S Nielsen, Erik H Larsen, Ole Ladefoged, Henrik R Lam
Manganese (Mn) is neurotoxic and can induce manganism, a Parkinson-like disease categorized as being a serious central nervous system irreversible neurodegenerative disease. An increased risk of developing symptoms of Parkinson disease has been linked to work-related exposure, for example, for workers in agriculture, horticulture, and people living near areas with frequent use of Mn-containing pesticides. In this study, the focus was placed on neurochemical effects of Mn. Rats were dosed intraperitoneally with 0...
January 1, 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/28347345/serotonergic-system-in-hypoxic-ventilatory-response-in-unilateral-rat-model-of-parkinson-s-disease
#12
Kryspin Andrzejewski, Katarzyna Kaczyńska, Małgorzata Zaremba
BACKGROUND: Malfunctioning of the serotonergic system in Parkinson's disease may contribute to non-motor symptoms such as respiratory complications. Thus the aim of our study was to investigate the role of serotonin 5-HT2 receptors in the modulation of normoxic breathing and the hypoxic ventilatory response (HVR) in rat model of Parkinson's disease. METHODS: Wistar rats were lesioned unilaterally with double 6-hydroxydopamine (6-OHDA) injection to the right medial forebrain bundle (MFB)...
March 27, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28294055/therapeutic-molecular-and-computational-aspects-of-novel-monoamine-oxidase-mao-inhibitors
#13
M Ramesh, Yussif M Dokurugu, Michael D Thompson, Mahmoud Soliman
Due to the limited number of MAOs inhibitors in the clinic and several research efforts are aimed at the discovery of novel MAOs inhibitors. At present, high specificity and a reversible mode of inhibition of MAO-A/B are cited as desirable traits in drug discovery process. This will help to reduce the probability of causing target disruption and may increase the duration of action. Most of the existing MAO inhibitors lead to side effects due to lack of affinity and selectivity. Therefore, there is an urgent need to design novel, potent, reversible and selective inhibitors for MAO-A/B...
March 10, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28159574/subthalamic-nucleus-deep-brain-stimulation-on-motor-symptoms-of-parkinson-s-disease-focus-on-neurochemistry
#14
REVIEW
A Stefani, V Trendafilov, C Liguori, E Fedele, S Galati
Deep brain stimulation (DBS) has become a standard therapy for Parkinson's disease (PD) and it is also currently under investigation for other neurological and psychiatric disorders. Although many scientific, clinical and ethical issues are still unresolved, DBS delivered into the subthalamic nucleus (STN) has improved the quality of life of several thousands of patients. The mechanisms underlying STN-DBS have been debated extensively in several reviews; less investigated are the biochemical consequences, which are still under scrutiny...
April 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28071873/cognitive-stress-reduces-the-effect-of-levodopa-on-parkinson-s-resting-tremor
#15
Heidemarie Zach, Michiel F Dirkx, Jaco W Pasman, Bastiaan R Bloem, Rick C Helmich
AIMS: Resting tremor in Parkinson's disease (PD) increases markedly during cognitive stress. Dopamine depletion in the basal ganglia is involved in the pathophysiology of resting tremor, but it is unclear whether this contribution is altered under cognitive stress. We test the hypothesis that cognitive stress modulates the levodopa effect on resting tremor. METHODS: Tremulous PD patients (n = 69) were measured in two treatment conditions (OFF vs. ON levodopa) and in two behavioral contexts (rest vs...
March 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27741357/dopamine-and-noradrenaline-but-not-serotonin-in-the-human-claustrum-are-greatly-reduced-in-patients-with-parkinson-s-disease-possible-functional-implications
#16
Harald H Sitte, Christian Pifl, Ali H Rajput, Heide Hörtnagl, Junchao Tong, George K Lloyd, Stephen J Kish, Oleh Hornykiewicz
In the human brain, the claustrum is a small subcortical telencephalic nucleus, situated between the insular cortex and the putamen. A plethora of neuroanatomical studies have shown the existence of dense, widespread, bidirectional and bilateral monosynaptic interconnections between the claustrum and most cortical areas. A rapidly growing body of experimental evidence points to the integrative role of claustrum in complex brain functions, from motor to cognitive. Here, we examined for the first time, the behaviour of the classical monoamine neurotransmitters dopamine, noradrenaline and serotonin in the claustrum of the normal autopsied human brain and of patients who died with idiopathic Parkinson's disease (PD)...
January 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27616337/activation-and-blockade-of-serotonin6-receptors-in-the-dorsal-hippocampus-enhance-t-maze-and-hole-board-performance-in-a-unilateral-6-hydroxydopamine-rat-model-of-parkinson-s-disease
#17
Kun Cheng Liu, Jun Yi Li, Wen Xie, Li Bo Li, Jin Zhang, Cheng Xue Du, Yu Ming Zhang, Hui Hui Tan, Hui Sheng Wang, Li Zhang
The role of dorsal hippocampus (DH) serotonin6 (5-HT6) receptors in memory is unknown, particularly in memory impairment of Parkinson's disease. We tested here effects of activation and blockade of DH 5-HT6 receptors on working and hippocampus-dependent memories in rats with unilateral 6-hydroxydopamine lesions of the medial forebrain bundle. The lesion induced working and hippocampus-dependent memory impairments as measured by the T-maze rewarded alternation and hole-board tests, and decreased dopamine (DA) levels in the striatum, medial prefrontal cortex (mPFC), DH and amygdala...
November 1, 2016: Brain Research
https://www.readbyqxmd.com/read/27591662/electrochemical-sensors-and-biosensors-for-determination-of-catecholamine-neurotransmitters-a-review
#18
REVIEW
José A Ribeiro, Paula M V Fernandes, Carlos M Pereira, F Silva
This work describes the state of the art of electrochemical devices for the detection of an important class of neurotransmitters: the catecholamines. This class of biogenic amines includes dopamine, noradrenaline (also called norepinephrine) and adrenaline (also called epinephrine). Researchers have focused on the role of catecholamine molecules within the human body because they are involved in many important biological functions and are commonly associated with several diseases, such as Alzheimer's and Parkinson...
November 1, 2016: Talanta
https://www.readbyqxmd.com/read/27491309/tyrosine-hydroxylase-th-its-cofactor-tetrahydrobiopterin-bh4-other-catecholamine-related-enzymes-and-their-human-genes-in-relation-to-the-drug-and-gene-therapies-of-parkinson-s-disease-pd-historical-overview-and-future-prospects
#19
REVIEW
Toshiharu Nagatsu, Ikuko Nagatsu
Tyrosine hydroxylase (TH), which was discovered at the National Institutes of Health (NIH) in 1964, is a tetrahydrobiopterin (BH4)-requiring monooxygenase that catalyzes the first and rate-limiting step in the biosynthesis of catecholamines (CAs), such as dopamine, noradrenaline, and adrenaline. Since deficiencies of dopamine and noradrenaline in the brain stem, caused by neurodegeneration of dopamine and noradrenaline neurons, are mainly related to non-motor and motor symptoms of Parkinson's disease (PD), we have studied human CA-synthesizing enzymes [TH; BH4-related enzymes, especially GTP-cyclohydrolase I (GCH1); aromatic L-amino acid decarboxylase (AADC); dopamine β-hydroxylase (DBH); and phenylethanolamine N-methyltransferase (PNMT)] and their genes in relation to PD in postmortem brains from PD patients, patients with CA-related genetic diseases, mice with genetically engineered CA neurons, and animal models of PD...
November 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27424103/activation-and-blockade-of-prelimbic-5-ht6-receptors-produce-different-effects-on-depressive-like-behaviors-in-unilateral-6-hydroxydopamine-induced-parkinson-s-rats
#20
Yu-Ming Zhang, Li Zhang, Yong Wang, Yi-Na Sun, Yuan Guo, Cheng-Xue Du, Jin Zhang, Lu Yao, Shu-Qi Yu, Jian Liu
The role of prelimbic (PrL) 5-HT6 receptors in depression is poorly understood, particularly in Parkinson's disease-related depression. Here we reported that 6-hydroxydopamine lesions in rats decreased sucrose preference and increased immobility time as measured by the sucrose preference and forced swim tests when compared to sham-operated rats, indicating the induction of depressive-like behaviors. Intra-PrL injection of 5-HT6 receptor agonist WAY208466 induced depressive-like responses in sham-operated rats, and produced antidepressant-like effects in the lesioned rats...
November 2016: Neuropharmacology
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