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Hydroxyethyl starch

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https://www.readbyqxmd.com/read/29324500/hydroxyethyl-starch-130-0-4-and-its-impact-on-perioperative-outcome-a-propensity-score-matched-controlled-observation-study
#1
Judith-Irina Pagel, Markus Rehm, Tobias Kammerer, Nikolai Hulde, Eike Speck, Josef Briegel, Falk Reinholz, Alexander Crispin, Klaus F Hofmann-Kiefer
BACKGROUND: Adverse effects of hydroxyethyl starches (HESs) have been verified in patients suffering from sepsis or kidney disease, but not in surgical patients at large. The investigation aimed to determine whether the use of HES 130/0.4 was associated with the incidence of acute postinterventional adverse events compared to Ringer's acetate alone in a perioperative setting. METHODS: This propensity score matched, controlled observational study was performed in a single-centre university hospital...
January 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29315987/compatibility-of-common-iv-drugs-with-6-hydroxyethyl-starch-130-0-42-and-4-gelatin
#2
Sebastian Heiderich, Anna Auf der Springe, Jonas Jürgens, Wolfgang Koppert, Andreas Leffler, Robert Sümpelmann, Nils Dennhardt
BACKGROUND: Acetate-containing colloid infusion solutions are recommended to recover normovolemia during pediatric anesthesia. Until now, no studies investigating the compatibility with common anesthetic drugs were available. AIMS: This in vitro study was conducted to reveal possible incompatibilities between common anesthetic drugs and the acetate-containing colloid infusion solutions 6% hydroxyethyl starch and 4% gelatin with normal saline as control. METHODS: The colloid infusion solutions were mixed 1:1 with 29 common intravenous drugs in concentrations used in daily clinical practice...
January 9, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29221978/influence-of-6-hydroxyethyl-starch-130-0-4-versus-crystalloid-solution-on-structural-renal-damage-markers-after-coronary-artery-bypass-grafting-a-post-hoc-subgroup-analysis-of-a-prospective-trial
#3
Thomas Datzmann, Markus Hoenicka, Helmut Reinelt, Andreas Liebold, Hagen Gorki
OBJECTIVE: The restriction of hydroxyethyl starch (HES) has mandated changes in volume management based on data of critically ill patients. Reliable data of structural renal damage after HES treatment in cardiac surgical patients are lacking. The influence of 6% HES 130/0.4 was investigated in this study. DESIGN: An exploratory post hoc subgroup analysis of a prospective trial was performed. SETTING: The study was carried out at a university hospital...
May 25, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29221748/hydroxyethyl-starch-is-associated-with-early-postoperative-delirium-in-patients-undergoing-esophagectomy
#4
Dae Myung Jung, Hyun Joo Ahn, Mikyung Yang, Jie Ae Kim, Duck Kyung Kim, Sangmin Maria Lee, Joo Hyun Park
OBJECTIVE: Postoperative delirium is associated with longer hospital stay and increased morbidities. Patients undergoing esophagectomy have a high chance of developing postoperative delirium because of their advanced age, comorbidities, and intensive care unit care. In this study, we investigated the risk factors of early postoperative delirium in patients undergoing esophagectomy, focusing on perioperative fluid type to test the hypothesis that colloids with high oncotic pressure and anti-inflammatory action would decrease the incidence of postoperative delirium compared with crystalloids...
December 5, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29199540/is-the-use-of-hydroxyethyl-starch-as-priming-solution-during-cardiac-surgery-advisable-a-randomized-single-center-trial
#5
Øyvind S Svendsen, Marit Farstad, Arve Mongstad, Rune Haaverstad, Paul Husby, Venny L Kvalheim
INTRODUCTION: The use of cardiopulmonary bypass (CPB) leads to increased fluid filtration and edema. The use of artificial colloids to counteract fluid extravasation during cardiac surgery is controversial. Beneficial effects on global fluid loading, leading to better cardiac performance and hemodynamics, have been claimed. However, renal function and coagulation may be adversely affected, with unfavorable impact on outcome following cardiac surgery. METHODS: Forty patients were randomly allocated to study groups receiving either acetated Ringer's solution (CT group) or hydroxyethyl starch (HES group, Tetraspan®) as CPB priming solution...
December 1, 2017: Perfusion
https://www.readbyqxmd.com/read/29181852/the-optimal-injection-solution-for-endoscopic-submucosal-dissection-a-randomized-controlled-trial-of-western-solutions-in-a-porcine-model
#6
Neal Mehta, Andrew T Strong, Matheus Franco, Tyler Stevens, Prabhleen Chahal, Sunguk Jang, Rocio Lopez, Deepa Patil, Seichiiro Abe, Yutaka Saito, Toshio Uraoka, John Vargo, Amit Bhatt
BACKGROUND: When performing endoscopic submucosal dissection (ESD), procedural safety increases with greater tissue elevation and efficiency increases with longer-lasting submucosal cushion. Fluids specifically developed for ESD in Asia aren't commercially available in the West, leading endoscopists to use a variety of injectable fluids off-label. To determine the optimal fluid available in the West, we compared commonly used fluids for Western ESD. METHODS: All phases were performed in an ex-vivo porcine stomach model...
November 27, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29174121/pro-third-generation-hydroxyethyl-starch-solution-is-safe-and-effective-for-plasma-volume-expansion-during-cardiac-surgery
#7
Matthew McConnell, Josh Baisden, Andra E Duncan
No abstract text is available yet for this article.
August 12, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29165077/physicochemical-and-toxic-properties-of-novel-genipin-drug-delivery-systems-prepared-by-mechanochemistry
#8
Wenhao Xu, Murong Wen, Weike Su, Alexander V Dushkin, Lubov P Suntsova, Irina D Markova, Olga Yu Selyutina, Nikolay E Polyakov
Complexes of Genipin and differents water-soluble adjuvant polysaccharides such as arabinogalactane, hydroxyethyl starch, fibergum,and oligosaccharides β-CD and HP-β-CD,were synthesized as drug delivery system using mechanochemical technology. We have investigated physicochemical properties, stability, and hepatotoxicity of the synthesized complexes in solid state and aqueous solution. The formation of the complexes was evidenced by different physical and spectroscopy assays, and the stability constants of our synthesized Genipin-based complexes were also calculated...
November 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29151081/association-between-standard-laboratory-and-functional-tests-of-coagulation-in-dilutional-coagulopathy-an-in-vitro-study
#9
L J Krzych, P F Czempik
Standard laboratory tests (SLTs) of coagulation are in common use in clinical practice. We aimed to determine the association between SLTs and functional tests of coagulation in blood samples diluted with balanced crystalloid and colloid solutions in an ex vivo setting. The study group comprised 32 healthy young male volunteers. Whole blood samples were diluted at a 4:1 ratio with balanced crystalloid (Plasmalyte®) and two balanced colloids, 6% hydroxyethyl starch 130/0.4 (Volulyte®) and succinylated gelatin (Geloplasma®)...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29150842/the-effect-of-6-hydroxyethyl-starch-130-0-4-on-acute-kidney-injury-in-paediatric-cardiac-surgery-a-prospective-randomised-trial
#10
H-W Oh, J-H Lee, H-C Kim, E-H Kim, I-K Song, H-S Kim, J-T Kim
We have evaluated the effect of a colloid solution on acute kidney injury in paediatric cardiac surgery. A total of 195 patients were ramdomly divided into an hydroxyethyl starch group and a control group. In the starch group, 6% hydroxyethyl starch 130/0.4 (Volulyte® ) was used as the primary fluid for volume resuscitation but was limited to 30 ml.kg-1 . In the control group, only crystalloid fluid was used during the peri-operative period. The incidence of acute kidney injury, peri-operative transfusion, clinical outcomes and laboratory data were compared...
November 17, 2017: Anaesthesia
https://www.readbyqxmd.com/read/29137091/the-effects-of-hypervolemic-infusion-on-microcirculation-perfusion-of-patients-during-laparoscopic-colorectal-surgery
#11
RANDOMIZED CONTROLLED TRIAL
Yunxin Deng, Qianlin Zhu, Buwei Yu, Minhua Zheng, Jue Jin
The aim of this study is to assess the effects of hypervolemic infusion with different solutions on microcirculation perfusion during laparoscopic colorectal surgery.Thirty-six patients were randomly divided into Ringer lactate solution [RL] group, succinylated gelatin injection [Gel] group, and hypertonic saline hydroxyethyl starch 40 injection [HS] group. Hypervolemic infusion was performed during the induction period of general anesthesia. Arterial blood-gas parameters, noninvasive hemodynamics, gastric tonometry values, and central venous pressure (CVP) were compared at baseline (T1); the end of hypervolemic infusion (T2); 5 min (T3), 15 min (T4), 30 min (T5), and 60 min (T6) during pneumoperitoneum; 5 min (T7), 15 min (T8), and 25 min (T9) after pneumoperitoneum...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29124920/nanocolloidosomes-with-selective-drug-release-for-active-tumor-targeted-imaging-guided-photothermal-chemo-combination-therapy
#12
Hang Hu, Chen Xiao, Honglian Wu, Yihui Li, Qing Zhou, Yuxiang Tang, Chan Yu, Xiangliang Yang, Zifu Li
Selective drug release is highly desirable for photothermal/chemo combination therapy when two or even more theranostic agents are encapsulated together within the same nanocarrier. Conventional nanocarrier can hardly achieve this goal. Herein, doxorubicin and indocyanine green (DOX/ICG) loaded nanocolloidosomes (NCs), with selective drug release, were fabricated as a novel multifunctional theranostic nanoplatform for photothermal/chemo combination therapy. Templating from galactose functionalized hydroxyethyl starch-polycaprolactone (Gal-HES-PCL) nanoparticles stabilized Pickering emulsions, the resultant DOX/ICG@Gal-HES-PCL NCs had a diameter around 140 nm and showed outstanding tumor targeting ability, preferable tumor penetration capability, and promoted photothermal effect...
November 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29115715/infusion-hemolysis-after-pediatric-major-abo-mismatched-bone-marrow-transplant-comparison-of-two-red-blood-cell-depletion-techniques
#13
Robert Sheppard Nickel, Muna Qayed, Diana Worthington-White, Sean R Stowell, Kuang-Yueh Chiang
BACKGROUND: During major ABO-mismatched bone marrow transplant (BMT), the infusion of incompatible red blood cells (RBCs) that are present in the bone marrow graft can cause adverse events from hemolysis. RBC depletion of the bone marrow graft can decrease this risk, but the optimal method to prevent hemolysis is unclear. PROCEDURE: We conducted a retrospective cohort study of patients who underwent major ABO-mismatched BMT at a pediatric center and had RBC depletion with either hydroxyethyl starch (HES) sedimentation or Ficoll density gradient separation...
November 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29099424/colloids-and-the-microcirculation
#14
Huaiwu He, Dawei Liu, Can Ince
Colloid solutions have been advocated for use in treating hypovolemia due to their expected effect on improving intravascular retention compared with crystalloid solutions. Because the ultimate desired effect of fluid resuscitation is the improvement of microcirculatory perfusion and tissue oxygenation, it is of interest to study the effects of colloids and crystalloids at the level of microcirculation under conditions of shock and fluid resuscitation, and to explore the potential benefits of using colloids in terms of recruiting the microcirculation under conditions of hypovolemia...
November 1, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29097283/biomolecular-engineering-of-biocatalysts-hydrolyzing-neurotoxic-organophosphates
#15
Ilya V Lyagin, Elena N Efremenko
Novel methods of molecular modeling help solving urgent problems in drug design, directed evolution of biocatalysts and biosensors, and a lot of other research fields. Implementation of such methods to organophosphorus hydrolase being perfect research object that hydrolyzes dangerous neurotoxic organophosphates could intensify development of antidote and protective preparations to treat poisoning. Structures of enzyme-polyelectrolyte complexes (EPCs) based on hexahistidine-tagged organophosphorus hydrolase (His6-OPH) with different biopolymers (various modifications of polyglutamic and polyaspartic acid, as well as hydroxyethyl starch and succinylated gelatin) were simulated at different pH using molecular docking...
October 30, 2017: Biochimie
https://www.readbyqxmd.com/read/29089656/evaluation-of-the-sterility-of-single-dose-medications-used-in-a-multiple-dose-fashion
#16
Elizabeth P Martin, Jean Mukherjee, Claire R Sharp, Virginia B Sinnott-Stutzman
Bacterial proliferation was evaluated in single-dose medications used in a multi-dose fashion and when medications were intentionally inoculated with bacteria. Of 5 experimentally punctured medications, 1 of 75 vials (50% dextrose) became contaminated. When intentionally inoculated, hydroxyethyl starch and heparinized saline supported microbial growth. Based on these findings, it is recommended that hydroxyethyl starch and heparinized saline not be used in a multi-dose fashion.
November 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/29083113/hydroxyethyl-starch-and-kidney-function-a-retrospective-study-in-patients-undergoing-therapeutic-plasma-exchange
#17
Muthuchellappan Radhakrishnan, Akshay Batra, Sundar Periyavan, Mariamma Philip, Vivek Anand
PURPOSE: Hydroxyethyl starch (HES) and albumin are used as replacement fluids during therapeutic plasma exchange (TPE). HES solutions are no longer recommended in critically ill patients due to its effect on kidneys and coagulation. In this retrospective study, we tried to look at the association between cumulative HES administration and kidney function in patients undergoing TPE. METHODS: Transfusion medicine department register was scrutinized to identify adult patients who had completed at least 5 cycles of TPE during the period June 2014-May 2015...
October 30, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/29071382/hydroxyethyl-starch-130-0-4-versus-crystalloid-co-loading-during-general-anesthesia-induction-a-randomized-controlled-trial
#18
Takashi Juri, Koichi Suehiro, Shigemune Kuwata, Sayaka Tsujimoto, Akira Mukai, Katsuaki Tanaka, Tokuhiro Yamada, Takashi Mori, Kiyonobu Nishikawa
PURPOSE: Hypotension and decreased cardiac output (CO) are common adverse effects during anesthesia induction depending on the patient's pre-anesthetic cardiac condition. The aim of this study was to assess the ability of hydroxyethyl starch (HES) 130/0.4 to prevent hypotension and decreased CO during the induction of general anesthesia. METHODS: Ninety patients undergoing laparoscopic surgery were randomly divided into a HES group and a crystalloid group. Following the insertion of an intravenous line, fluid was administered to each patient at a rate of 25 ml/min using either crystalloid or HES 130/0...
December 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/29064872/no-differences-in-renal-function-between-balanced-6-hydroxyethyl-starch-130-0-4-and-5-albumin-for-volume-replacement-therapy-in-patients-undergoing-cystectomy-a-randomized-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Tobias Kammerer, Florian Brettner, Sebastian Hilferink, Nikolai Hulde, Florian Klug, Judith Pagel, Alexander Karl, Alexander Crispin, Klaus Hofmann-Kiefer, Peter Conzen, Markus Rehm
BACKGROUND: The use of artificial colloids has declined in critical care, whereas they are still used in perioperative medicine. Little is known about the nephrotoxic potential in noncritically ill patients during routine surgery. The objective of this trial was to evaluate the influences of albumin 5% and balanced hydroxyethyl starch 6% (130/0.4) on renal function and kidney injury. METHODS: One hundred urologic patients undergoing elective cystectomy were randomly assigned for this prospective, single-blinded, controlled study with two parallel groups to receive either albumin 5% or balanced hydroxyethyl starch 6% (130/0...
January 2018: Anesthesiology
https://www.readbyqxmd.com/read/29052006/risk-factors-for-and-the-prevention-of-acute-kidney-injury-after-abdominal-surgery
#20
REVIEW
Yongbo An, Kai Shen, Yingjiang Ye
Postoperative acute kidney injury in patients undergoing abdominal surgery is not rare and often results in bad outcomes for patients. The incidence of postoperative acute kidney injury is hard to evaluate reliably due to its non-unified definitions in different studies. Risk factors for acute kidney injury specific to abdominal surgery include preoperative renal insufficiency, intraabdominal hypertension, blood transfusion, bowel preparation, perioperative dehydration, contrast agent and nephrotoxic drug use...
October 19, 2017: Surgery Today
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