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https://www.readbyqxmd.com/read/28790453/perianal-fistulizing-crohn-s-disease-pathogenesis-diagnosis-and-therapy
#1
REVIEW
Julián Panés, Jordi Rimola
Perianal fistulizing Crohn's disease has a major negative effect on patient quality of life and is a predictor of poor long-term outcomes. Factors involved in the pathogenesis of perianal fistulizing Crohn's disease include an increased production of transforming growth factor β, TNF and IL-13 in the inflammatory infiltrate that induce epithelial-to-mesenchymal transition and upregulation of matrix metalloproteinases, leading to tissue remodelling and fistula formation. Care of patients with perianal Crohn's disease requires a multidisciplinary approach...
August 9, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28782667/features-of-autoimmune-pancreatitis-associated-with-inflammatory-bowel-diseases
#2
Diane Lorenzo, Frédérique Maire, Carmen Stefanescu, Jean-Marc Gornet, Philippe Seksik, Mélanie Serrero, Barbara Bournet, Philippe Marteau, Aurelien Amiot, David Laharie, Caroline Trang, Benoit Coffin, Guy Bellaiche, Guillaume Cadiot, Catherine Reenaers, Antoine Racine, Stephanie Viennot, Arnaud Pauwels, Guillaume Bouguen, Guillaume Savoye, Anne-Laure Pelletier, Guillaume Pineton de Chambrun, Pierre Lahmek, Stéphane Nahon, Vered Abitbol
BACKGROUND & AIMS: Few people know of autoimmune pancreatitis (AIP), a rare disorder associated with inflammatory bowel diseases (IBD). We aimed to describe phenotype and outcomes of AIP in patients with AIP. METHODS: We performed a retrospective study of cases of AIP in IBD identified from the multi-center Groupe d'Etude Thérapeutique des Affections Inflammatoires du tube Digestif study, performed in Belgium and France from July 2012 through July 2015. Patients were diagnosed with AIP based on histological analysis of pancreatic resection specimens or samples collected by fine-need aspiration during endoscopic ultrasound...
August 3, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28761891/ischemic-proctitis-presenting-as-rectal-pain-and-bloody-diarrhea-with-no-apparent-cause
#3
Kyle J Fortinsky, Fayez Quereshy, Stephano Serra, Flavio Habal
Acute ischemic proctitis is a rare condition usually resulting from severe vascular disease or an acute vascular occlusion. The diagnosis is made on endoscopy, and mortality rates approach 20-40%. Many patients will require a proctectomy as the definitive treatment, especially for gangrenous proctitis. We describe an unusual presentation of acute ischemic proctitis in a patient without preexisting vascular disease or other precipitants. Furthermore, our patient recovered entirely with conservative management and intravenous antibiotics alone...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28755790/correlation-between-disease-activity-and-endorectal-ultrasound-findings-of-chronic-radiation-proctitis
#4
Fei Cao, Teng-Hui Ma, Guang-Jian Liu, Yan-Lin Wen, Huai-Ming Wang, Ying-Yi Kuang, Si Qin, Xiao-Yin Liu, Bin-Jie Huang, Lei Wang
The aim of this study was to summarize the imaging features of chronic radiation proctitis (CRP) on endorectal ultrasound (ERUS) and investigate the value of ERUS in the evaluation of disease activity. 40 CRP patients and 30 control patients were investigated by ERUS. Rectal wall thickness and layers, ulcers and rectovaginal fistulas were evaluated by B-mode ultrasound. Power Doppler imaging was used to evaluate the vascularity of the rectal wall using a semiquantitative score. Disease activity was calculated according to the National Cancer Institute Common Terminology Criteria for Adverse Events 4...
July 26, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28747059/rectal-inflammatory-stenosis-secondary-to-chlamydia-trachomatis-a-case-report
#5
Luis Eduardo Pérez Sánchez, Moisés Hernández Barroso, Guillermo Hernández Hernández
The rectal inflammatory originated strictures constitute a rare cause of intestinal obstruction. We present a 30-year-old male patient with a history of HIV and protctitis caused by Chalmydia trachomatis and HSV-2, in which develops a low intestinal obstruction refractory to medical treatment. Surgery was performed with good clinical evolution. The medical treatment constitutes the fundamental basis of the therapy in these patients. Despite that, when fibrotic stenoses are not treatable medical or endoscopically, they often require surgical treatment...
July 27, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28724302/efficacy-and-safety-of-vedolizumab-as-a-treatment-option-for-moderate-to-severe-refractory-ulcerative-colitis-in-two-patients-after-liver-transplant-due-to-primary-sclerosing-cholangitis
#6
Raúl Vicente Olmedo Martín, Víctor Amo Trillo, Rocío González Grande, Miguel Jiménez Pérez
Vedolizumab is a humanized IgG1 monoclonal antibody that selectively blocks the lymphocyte integrin α4β7 and prevents its interaction with endothelial adhesion molecules and subsequent transmigration to the gastrointestinal tract. The drug was approved in 2014 for the induction and maintenance treatment of ulcerative colitis and moderate to severe Crohn's disease that is refractory or intolerant to conventional treatment with corticoids and immunosuppressants and/or anti-TNFα drugs. However, inflammatory bowel disease has a variable behavior following liver transplant...
July 14, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28722452/-lymphogranuloma-venereum
#7
Michaela Vyšatová
Lymphogranuloma venereum belongs to the sexually transmitted diseases. The disease is caused by Chlamydia trachomatis serotypes L1, L2 and L3. In the beginning of the 21st century there has been observed a large increase in the incidence of this disease in the world. There is a frequent co-occurrence with other sexually transmitted diseases (HIV, syphilis, gonorrhea, hepatitis C). Predominantly this disease affects homosexuals, in which case the first manifestation of the disease may be proctitis or proctocolitis...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28707144/efficacy-and-safety-of-argon-plasma-coagulation-in-the-management-of-extensive-chronic-radiation-proctitis-after-pelvic-radiotherapy-for-cervical-carcinoma
#8
Shyama Prem Sudha, D Kadambari
INTRODUCTION: Chronic radiation proctitis (CRP) usually develops 90 days or more after radiation. Currently, there is no standard available for the treatment of CRP. In argon plasma coagulation, monopolar diathermy is used to ionise the argon gas which coagulates the telengiectatic vessels in a noncontact fashion. However, there are very few studies which have reported its use in extensive CRP. We report the efficacy and safety of APC in seven patients with recurrent, extensive grade 3 radiation proctitis...
July 13, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28703111/clinical-and-microbiological-aspects-of-the-use-of-lactobacillus-rhamnosus-pl1-strains-in-proctological-patients-with-symptoms-of-chronic-proctitis
#9
K Borycka-Kiciak, M Strus, P Pietrzak, K Wawiernia, D Mikołajczyk, M Gałęcka, P Heczko, W Tarnowski
Recurrent proctitis and the symptoms associated therewith pose significant clinical problem in proctological patients. The objective of this study was to assess the impact of the probiotic Lactobacillus rhamnosus PL1 strain on the clinical presentation and composition of intestinal microbiota in patients with symptoms of proctitis in the course of hemorrhoidal disease and diverticulosis. Material consisted of 24 patients in whom no complete clinical improvement could be obtained after the treatment of the underlying disease...
June 30, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28694461/endothelial-hey2-deletion-reduces-endothelial-to-mesenchymal-transition-and-mitigates-radiation-proctitis-in-mice
#10
Elodie Mintet, Jérémy Lavigne, Vincent Paget, Georges Tarlet, Valérie Buard, Olivier Guipaud, Jean-Christophe Sabourin, Maria-Luisa Iruela-Arispe, Fabien Milliat, Agnès François
The current study evaluated the role of Hey2 transcription factor in radiation-induced endothelial-to-mesenchymal transition (EndoMT) and its impact on radiation-induced tissue damage in mice. Phenotypic modifications of irradiated, Hey2 siRNA- and Hey2 vector plasmid-transfected human umbilical vein endothelial cells (HUVECs) resembling EndoMT were monitored by qPCR, immunocytochemistry and western blots. Subsequently, in mice, a Cre-LoxP strategy for inactivation of Hey2 specifically in the endothelium was used to study the biological consequences...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28666605/therapeutic-requirements-in-active-ulcerative-proctitis-a-single-centre-study
#11
Margalida Calafat, Triana Lobatón, Míriam Mañosa, Laura Marín, Noemí Caballero, Macarena Larraín, Eduard Cabré, Eugeni Domènech
BACKGROUND: Ulcerative proctitis (UP) presents distinctive clinical characteristics, outcomes and therapeutic approaches as compared to left-sided and extensive ulcerative colitis (UC). AIM: To describe the current therapeutic requirements and clinical outcomes in patients with active UP. METHODS: Retrospective observational study conducted in a referral IBD centre. Patients with UP in follow-up between 1989 and 2014 were included. The clinical characteristics, as well as the different treatments and drug formulations administered to treat flares, were recorded...
June 27, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28655079/-pathological-insights-of-radiotherapy-related-damage-to-surgical-margin-after-preoperative-radiotherapy-in-patients-with-rectal-cancer
#12
RANDOMIZED CONTROLLED TRIAL
Q H Zhong, P H Wu, Q Y Qin, Y Y Kuang, T H Ma, H M Wang, Y X Zhu, D C Chen, J P Wang, L Wang
Objective: To investigate the effect of irradiation to anastomosis from preoperative radiotherapy for patients with rectal cancer by studying the pathological changes. Methods: In this retrospective study, patients enrolled in the FOWARC study from January 2011 to July 2014 in the Sixth Affiliated Hospital of Sun Yat-Sen University were included. In the FOWARC study, enrolled patients with local advanced rectal cancer were randomly assigned to receive either neoadjuvant chemo-radiotherapy or chemotherapy. Among these patients, 23 patients were selected as radiation proctitis (RP)group, who fulfilled these conditions: (1) received neoadjuvant chemo-radiotherapy followed by sphincter-preserving surgery; (2) developed radiation proctitis as confirmed by preoperative imaging diagnosis; (3) had intact clinical samples of surgical margins...
July 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28644308/the-use-of-5-aminosalicylic-acid-in-children-and-adolescents-with-inflammatory-bowel-disease
#13
Christiane Sokollik, Nicolas Fournier, David Rizzuti, Christian P Braegger, Andreas Nydegger, Susanne Schibli, Johannes Spalinger
BACKGROUND: In ulcerative colitis (UC) 5-aminosalicylic acid (5-ASA) is recommended as primary therapy for mild to moderate disease. Topical 5-ASA has been proven especially effective. In Crohn's disease (CD) the evidence for a beneficial role of 5-ASA is weak. We investigated the use of topical and systemic 5-ASA therapy in children and adolescents with inflammatory bowel disease. MATERIALS AND METHODS: Data of patients younger than 18 years, registered between April 2008 and December 2015 in the Swiss Inflammatory Bowel Disease Cohort, were analyzed...
June 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28631649/chlamydia-trachomatis-proctitis-masquerading-as-carcinoma-rectum-first-case-report-from-india
#14
Benu Dhawan, Govind Kumar Makharia, Deepak Juyal, Sujeesh Sebastian, Riti Bhatia, Neena Khanna
While proctitis is caused both by infectious and noninfectious causes, infectious causes are acquired typically sexually. Chlamydia trachomatis, which is the most frequent bacterial pathogen causing sexually transmitted infections worldwide, is one of the causative agents of proctitis. We report a case history of a bisexual male who presented to us with rectal bleeding. The colonoscopy showed a nodular ulcerated lesion in the rectum suggestive of rectal malignancy, but biopsies from rectal mass did not reveal malignancy...
April 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28621077/editorial-does-disease-extension-lead-to-disease-progression-in-proctitis
#15
EDITORIAL
M J Lamba, V S Tharayil, R B Gearry
No abstract text is available yet for this article.
July 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28618234/successful-treatment-of-acute-radiation-proctitis-with-aloe-vera-a-preliminary-randomized-controlled-clinical-trial
#16
Adeleh Sahebnasagh, Arash Ghasemi, Jafar Akbari, Abbas Alipour, Hossein Lashkardoost, Shahram Ala, Ebrahim Salehifar
BACKGROUND: Acute radiation proctitis (ARP) is a common side-effect that affects up to 50% of patients receiving radiotherapy. The aim of this study was to evaluate the role of a topical preparation of Aloe vera in the treatment of ARP induced by radiotherapy of pelvic area. SUBJECTS AND INTERVENTIONS: In this double-blind placebo-controlled trial, 20 consecutive patients with ARP after external-beam radiation therapy (46-72 Gy) of pelvic malignancies were randomized to receive either Aloe vera 3% or placebo ointment, 1 g twice daily for 4 weeks...
June 15, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28590237/evaluation-of-self-collected-rectal-swabs-for-the-detection-of-bacteria-responsible-for-sexually-transmitted-infections-in-a-cohort-of-hiv-1-infected-patients
#17
Sophie Edouard, Catherine Tamalet, Hervé Tissot-Dupont, Philippe Colson, Amélie Ménard, Isabelle Ravaux, Catherine Dhiver, Christelle Tomei, Andreas Stein, Didier Raoult
PURPOSE: The standard approach to screening sexually transmitted infections (STIs) has often been restricted to urogenital specimens. Most current guidelines, however, also recommend testing extra-genital sites, including rectal locations, because asymptomatic rectal carriage of pathogens has often been reported. The aim of our study was to evaluate self-collected rectal swabs to screen bacterial STIs in HIV-infected patients in Marseille, France. METHODOLOGY: Between January 2014 and December 2015, 118 HIV-infected patients (93 males and 25 females) agreed to self-sample anal swabs for detection of bacterial STI...
June 8, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28588887/risk-factors-for-proximal-disease-extension-and-colectomy-in-left-sided-ulcerative-colitis
#18
S Sahami, K Konté, C J Buskens, P J Tanis, M Löwenberg, C J Ponsioen, G R van den Brink, W A Bemelman, G R D'Haens
OBJECTIVE: The primary objective of this study was to assess proximal disease extension of ulcerative colitis (UC) over time, with disease behaviour pattern and risk factors for proximal disease extension and colectomy as secondary aims. METHODS: All cumulative incident cases diagnosed with UC at the Academic Medical Center between January 1990 and December 2009 were studied. The cumulative risk of colectomy was calculated by Kaplan-Meier analysis. The Cox proportional hazards regression was used to identify risk factors associated with proximal disease extension and colectomy...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28473937/herpes-simplex-proctitis-mimicking-inflammatory-bowel-disease-in-a-teenaged-male
#19
Kristen E Sandgren, Nathan B Price, Warren P Bishop, Patrick J McCarthy
We report the case of a 17-year-old male who was initially assessed for pain with defecation, bloody rectal discharge, and diarrhea, consistent with proctitis. Though proctitis is most commonly due to inflammatory bowel disease (IBD), infectious etiologies must also be considered, including sexually transmitted causes of infectious proctitis. In discussion of his sexual history, he identified as homosexual and acknowledged engaging in receptive anal intercourse. Rectal biopsies obtained via colonoscopy were culture-positive for herpes simplex virus (HSV), leading to a diagnosis of HSV proctitis and treatment with an appropriate antiviral medication...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/28468648/expedited-partner-therapy-ept-increases-the-frequency-of-partner-notification-among-msm-in-lima-peru-a-pilot-randomized-controlled-trial
#20
Jesse L Clark, Eddy R Segura, Catherine E Oldenburg, Jessica Rios, Silvia M Montano, Amaya Perez-Brumer, Manuel Villaran, Jorge Sanchez, Thomas J Coates, Javier R Lama
BACKGROUND: Expedited Partner Therapy (EPT) has been shown to improve treatment outcomes among heterosexual partners of individuals with curable sexually transmitted infections (STIs). Although the use of EPT with men who have sex with men (MSM) has been debated, due to the potential for missed opportunities to diagnose unidentified cases of HIV and syphilis infection in symptomatic partners, increases in partner notification (PN) resulting from use of EPT may promote testing and treatment of otherwise unidentified partners...
May 4, 2017: BMC Medicine
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