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https://www.readbyqxmd.com/read/29207381/alicaforsen-an-antisense-inhibitor-of-intercellular-adhesion-molecule-1-in-the-treatment-for-left-sided-ulcerative-colitis-and-ulcerative-proctitis
#1
Thomas Greuter, Stephan R Vavricka, Luc Biedermann, Julia Pilz, Jan Borovicka, Frank Seibold, Bernhard Sauter, Gerhard Rogler
BACKGROUND: Data on the efficacy of intercellular adhesion molecule-1 antisense oligonucleotide alicaforsen in ulcerative colitis (UC) is inconsistent. METHODS: All patients, who had received at least one dose of alicaforsen, were analyzed retrospectively. Alicaforsen's efficacy was assessed in patients treated for left-sided UC and proctitis by comparing clinical and (if applicable) endoscopic disease activity before/after treatment. RESULTS: Twelve patients were treated for left-sided UC or proctitis...
December 5, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/29205498/efficacy-of-topical-5-aminosalicylate-monotherapy-in-patients-with-ulcerative-proctitis-with-skip-inflammation
#2
Yong Sung Choi, Wan Jung Kim, Jong Kyu Kim, Do Sun Kim, Doo Han Lee
BACKGROUNDS: In some patients with ulcerative proctitis (UP), skip inflammation is noted in the right side of the colon, but little is known about its clinical course. The aim of this study was to evaluate the clinical course of UP with skip inflammation and the efficacy of topical 5-ASA monotherapy. METHODS: We reviewed the data of 388 patients with an initial diagnosis of UP from January 2005 to October 2015. We matched each UP patient with skip inflammation 1:2 with controls who had UP without skip inflammation; to reduce bias, we matched the controls with the cases by age, gender, and initial disease activity...
December 4, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29204159/what-pelvic-radiation-disease-symptoms-are-experienced-by-patients-receiving-external-beam-radiotherapy-and-a-high-dose-rate-brachytherapy-boost-for-prostate-cancer
#3
Georgia K B Halkett, Michala Short, Samar Aoun, David Joseph, Sean Bydder, Xingqiong Meng, Nigel Spry
Purpose: Research describing proctitis or pelvic radiation disease symptoms of prostate cancer patients one year after external beam radiotherapy (EBRT) plus high-dose-rate (HDR) brachytherapy is limited. This study aimed to assess prostate cancer patients' pelvic radiation disease symptoms from baseline to 12 months post-radiotherapy. Material and methods: Men with prostate cancer referred for EBRT and HDR brachytherapy were recruited. Patients' age, diagnosis, staging, PSA, past medical history, and treatment were recorded...
October 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29186737/the-role-of-confocal-laser-endomicroscopy-in-assessing-mucosal-healing-in-patients-with-ulcerative-proctitis
#4
Cristian Gheorghe, Gabriel Becheanu, Razvan Iacob, Bogdan Cotruta, Anca Dimitriu
No abstract text is available yet for this article.
December 2017: Endoscopy
https://www.readbyqxmd.com/read/29182384/efficacy-of-a-rectal-spacer-with-prostate-sabr-first-uk-experience
#5
Raymond B King, Sarah Os Osman, Ciaran Fairmichael, Denise M Irvine, Ciara A Lyons, Ananth Ravi, Joe M O'Sullivan, Alan R Hounsell, Darren M Mitchell, Conor K McGarry, Suneil Jain
OBJECTIVE: This study assessed the use of implanted hydrogel rectal spacers for SABR-VMAT patients, investigating practicality, dosimetric impact, normal tissue complication probability (NTCP) and early toxicity. METHODS: Data from the first 6 patients treated within a prostate SABR and rectal spacer trial were examined to determine spacer insertion tolerability, resultant changes in treatment planning and dosimetry and early toxicity effects. CT scans acquired prior to spacer insertion were used to generate SABR plans which were compared to post-insertion CT plans...
November 28, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29171166/outcomes-of-asian-patients-with-localized-prostate-cancer-treated-with-combined-intensity-modulated-radiation-therapy-imrt-and-high-dose-rate-hdr-brachytherapy-a-single-institution-experience
#6
Ivy Wei Shan Ng, Jeremy Chee Seong Tey, Yu Yang Soon, Michelle Shu Fen Tseng, Desiree Chen, Keith Hsiu Chin Lim
AIM: External beam radiotherapy (EBRT) followed by high dose rate (HDR) brachytherapy boost has demonstrated minimal toxicities and improved disease control rate compared with EBRT alone in observational and randomized studies with predominantly Caucasian patients. This study aims to report the outcomes of patients treated with this approach in our predominantly Asian population. METHODS: Medical records for patients with localized prostate cancer who received combined EBRT delivered via intensity modulated radiotherapy (IMRT) technique followed by HDR brachytherapy boost were retrospectively reviewed...
November 23, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29158782/a-phase-ii-trial-of-preoperative-concurrent-chemotherapy-and-dose-escalated-intensity-modulated-radiotherapy-imrt-for-locally-advanced-rectal-cancer
#7
Jeremy Tey, Cheng Nang Leong, Wai Kit Cheong, Tay Guan Sze, Wei Peng Yong, Ivan Weng Keong Tham, Khai Mun Lee
Objectives: To determine the pathological response rates and toxicity and in patients with locally advanced rectal cancer treated with concurrent capecitabine and dose escalated intensity modulated radiotherapy (IMRT) Methods: Patients with stage II or III adenocarcinoma of the rectum were treated with preoperative concurrent capecitabine and IMRT. Dose of capecitabine was 825mg/m(2), 5 days a week for 5 weeks. IMRT was used to deliver a dose of 45Gy in 25 fractions (1.8Gy per fraction daily, 5 days a week over 5 weeks) to the regional lymphatics and areas at risk of harbouring microscopic disease...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29158365/phase-ii-trial-using-a-combination-of-oxaliplatin-capecitabine-and-celecoxib-with-concurrent-radiation-for-newly-diagnosed-resectable-rectal-cancer
#8
Emilio P Araujo-Mino, Yehuda Z Patt, Cristina Murray-Krezan, Joshua A Hanson, Pranshu Bansal, Ben J Liem, Ashwani Rajput, M Houman Fekrazad, Glenory Heywood, Fa Chyi Lee
LESSONS LEARNED: Colorectal cancers exhibit a high level of cyclooxygenase-2 (COX-2) expression with strong preclinical rationale for improved clinical outcomes with COX-2 inhibition. Celecoxib is a COX-2 inhibitor and we have shown that it can be safely combined with capecitabine and oxaliplatin as part of neoadjuvant treatment with radiation therapy (RT) in rectal cancer.There was a significant improvement in skin toxicity with this combination as compared with historical data. Considering the field has moved on to single-agent capecitabine, we believe future trials with capecitabine and celecoxib hold potential...
November 20, 2017: Oncologist
https://www.readbyqxmd.com/read/29151782/salvage-low-dose-rate-brachytherapy-for-recurrent-prostate-cancer-after-external-beam-radiotherapy-results-from-a-single-institution-with-focus-on-toxicity-and-functional-outcomes
#9
F Barbera, L Triggiani, M Buglione, P Ghirardelli, P Vitali, B Caraffini, P Borghetti, D Greco, L Bardoscia, N Pasinetti, L Costa, M Maddalo, B Ghedi, B La Face, S M Magrini
Background/aim: Low dose rate brachytherapy has been used as salvage therapy for locally recurrent prostate cancer (PC) after primary external beam radiation therapy (EBRT), along with surgery and cryotherapy. All these techniques, in particular, when applied to the whole gland, involve a relatively high risk of toxicity and may worsen the patient's quality of life. Our aim is to evaluate the results of whole-gland salvage brachytherapy (SBT) after primary EBRT in terms of toxicity, functional outcomes, and efficacy...
2017: Clinical Medicine Insights. Oncology
https://www.readbyqxmd.com/read/29130230/-protective-measures-in-laparoscopic-resection-for-upper-or-mid-rectal-cancer-and-sigmoid-colon-cancer-with-transrectal-specimen-extraction-surgery
#10
Chuangang Fu, Zhuqing Zhou, Junyi Han, Bin Lu, Wei Gao, Zhe Zhu, Qixin Jiang, Fang Ji, Tao Du
OBJECTIVE: To introduce the use of a self-made specimen protective sleeve in laparoscopic resection for upper or mid rectal cancer and sigmoid colon cancer with transrectal specimen extraction surgery and the improvement of implantation method, so as to avoid and reduce bacterial contamination and tumor cell dissemination in abdominal cavity. METHODS: During June 2015 and May 2017, 48 cases of high located rectal or sigmoid colon cancer were operated laparoscopically with natural orifices specimen extraction surgery (NOSES) using a self-made specimen protecting sleeve...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29129577/pelvic-bone-anatomy-vs-implanted-gold-seed-marker-registration-for-image-guided-intensity-modulated-radiotherapy-for-prostate-carcinoma-comparative-analysis-of-inter-fraction-motion-and-toxicities
#11
Madhup Rastogi, Sambit Swarup Nanda, Ajeet Kumar Gandhi, Divakar Dalela, Rohini Khurana, Surendra Prasad Mishra, Anoop Srivastava, S Farzana, Madan Lal Brahma Bhatt, Nuzhat Husain
OBJECTIVES: We compared the prostate motion variability and toxicities between patients treated with gold marker registration based IG-IMRT (IG-IMRT-M) and bony landmark registration based IG-IMRT (IG-IMRT-B). METHODS: T1c-T3b (node negative), intermediate and high risk (non-metastatic) adenocarcinoma of prostate, age ≥18years, Karnofsky Performance Status of ≥70 were included in this retrospective study. The prostate motion variability, acute and late radiation toxicities between the two treatment arms (IG-IMRT-M versus IG-IMRT-B) were compared...
November 9, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29102738/manual-vs-automated-implantation-of-seeds-in-prostate-brachytherapy-oncologic-results-from-a-single-center-study
#12
Laurence Thomas, Antony Chemin, Nicolas Leduc, Sarah Belhomme, Emilie Rich, Olivier Lasbareilles, Antoine Giraud, Edouard Descat, Guilhem Roubaud, Paul Sargos
PURPOSE: The objective of this study was to study survival and tolerance of prostate cancer patients treated with (125)I permanent interstitial brachytherapy by automated vs. manual implantation of seeds. METHODS AND MATERIALS: Between 2002 and 2010, 349 selected patients were treated with (125)I brachytherapy by the same team: from 2002 to April 2005, 65 patients with linked seeds and then 284 patients treated using Nucletron First System automated implantation...
November 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29081376/new-indications-for-endoscopic-radiofrequency-ablation
#13
Thomas R McCarty, Tarun Rustagi
Radiofrequency ablation (RFA) is a well-established treatment for several benign, pre-malignant, and malignant disorders. Although the role of RFA has been clearly defined, new indications for luminal and extra-luminal applications of endoscopic RFA-directed therapies have emerged. RFA has recently produced promising results in patients with a variety of gastrointestinal and hepatopancreatobiliary pathologies. For example, endoscopic RFA has been used to treat patients with gastric antral vascular ectasia, chronic radiation proctitis, malignant biliary strictures, and ampullary adenomas with intraductal extension...
October 25, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29080145/role-of-angiogenesis-in-chronic-radiation-proctitis-new-evidence-favoring-inhibition-of-angiogenesis-ex-vivo
#14
Peihuang Wu, Li Li, Huaiming Wang, Tenghui Ma, Haiyong Wu, Xinjuan Fan, Zihuan Yang, Daici Chen, Lei Wang
BACKGROUND: Chronic radiation proctitis (CRP), a common complication after radiotherapy for pelvic malignancies, compromises patient quality of life. Vascular damage and aberrant angiogenesis in the mucosal layer are essential histological features, but changes to the submucosal layer are unclear. Thus, we evaluated the histological characteristics and distribution changes of key angiogenic factors in full-layered human CRP samples. METHODS: Thirty paraffin-embedded CRP and twenty-nine non-CRP tissues were used to evaluate histopathological changes...
October 27, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29067152/are-patients-in-the-ibd-clinic-at-risk-of-proctitis-secondary-to-sexually-transmitted-infections
#15
Maximillian Groome, Emma M Robinson, Craig Mowat, Alix M L Morieux, Sarah Allstaff
OBJECTIVE: To gauge the potential risk of sexually transmitted infection (STI) as a cause of proctitis in a cohort of patients with inflammatory bowel disease (IBD) and to gauge whether this cohort could benefit from STI testing in the future. DESIGN: Patients attending the IBD clinic were given an anonymous questionnaire recording demographics, sexual behaviour, rectal symptoms, history of receptive anal intercourse (RAI), STIs and attitudes towards sexual health screening...
October 2017: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29052254/genetic-polymorphisms-associated-with-smoking-behaviour-predict-the-risk-of-surgery-in-patients-with-crohn-s-disease
#16
B M Lang, L Biedermann, W T van Haaften, C de Vallière, M Schuurmans, S Begré, J Zeitz, M Scharl, M Turina, T Greuter, P Schreiner, H Heinrich, T Kuntzen, S R Vavricka, G Rogler, N Beerenwinkel, B Misselwitz
BACKGROUND: Smoking is a strong environmental factor leading to adverse outcomes in Crohn's disease, but a more benign course in ulcerative colitis. Several single nucleotide polymorphisms (SNPs) are associated with smoking quantity and behaviour. AIMS: To assess whether smoking-associated SNPs interact with smoking to influence the clinical course of inflammatory bowel diseases. METHODS: Genetic and prospectively obtained clinical data from 1434 Swiss inflammatory bowel disease cohort patients (821 Crohn's disease and 613 ulcerative colitis) were analysed...
October 20, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29020255/mini-fecal-microbiota-transplantation-mini-fmt-for-treatment-of-clostridium-difficile-proctitis-following-total-colectomy
#17
Robert Orenstein, Kara King, Roberto L Patron, John K DiBaise, David Etzioni
Rarely, in fulminant Clostridium difficile infection, the rectal stump is persistently infected following total abdominal colectomy. We report cure of a septic patient with proctitis by fecal microbiota transplant via rectal swabs (mini-FMT). This novel procedure offers a management option for recurrent CDI following total abdominal colectomy.
August 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28963746/expression-of-vascular-endothelial-growth-factor-vegf-and-its-correlation-with-clinical-symptoms-and-endoscopic-findings-in-patients-with-chronic-radiation-proctitis
#18
Radzislaw Trzcinski, Adam Dziki, Magdalena Brys, Malgorzata Moszynska-Zielinska, Justyna Chalubinska-Fendler, Michal Mik, Ryszard Kujawski, Lukasz Dziki
INTRODUCTION: The aim of this study was to assess the expression of vascular endothelial growth factor (VEGF) as a key proangiogenic factor and determine whether there is any correlation between its expression and clinical symptoms or endoscopic changes in patients with chronic radiation proctitis (ChRP). METHOD: Fifty patients who had all undergone radiotherapy for prostate, cervical and uterine cancers were included in the study (37 females, 13 males). There was a control group of 20 patients (9 females, 11 males)...
September 29, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28943174/increase-in-sexually-transmitted-infections-in-a-cohort-of-outpatient-hiv-positive-men-who-have-sex-with-men-in-the-parisian-region
#19
E Farfour, S Dimi, C Majerholc, E Fourn, T Séné, M B Chaida, M Vasse, D Zucman
OBJECTIVE: To describe the increased incidence of sexually transmitted infections (STIs) in a cohort of HIV-infected men who have sex with men (MSM), followed in a tertiary hospital of the Île-de-France region. MATERIALS AND METHODS: We performed a monocentric, retrospective, and prospective study. We included symptomatic HIV-infected MSM patients who consulted for their annual consultation. RESULTS: One hundred and eighty patients were seen between 2008-2011 and 215 between 2012-2015...
November 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28924967/postoperative-radiotherapy-for-prostate-cancer-the-sooner-the-better-and-potential-to-reduce-toxicity-even-further
#20
Paolo Borghetti, Luigi Spiazzi, Claudia Cozzaglio, Sara Pedretti, Bruno Caraffini, Luca Triggiani, Diana Greco, Lilia Bardoscia, Fernando Barbera, Michela Buglione, Stefano Maria Magrini
PURPOSE: To evaluate biochemical relapse-free survival (bRFS), overall survival (OS), late rectal and bladder toxicities in a retrospective single institution series, also applying an in-house software for biological dose calculation. METHODS: 258 patients submitted to radiotherapy after prostatectomy were considered. Differences between groups were calculated using the log-rank test and the relevant clinical and therapeutic variables were considered for multivariate analysis...
September 18, 2017: La Radiologia Medica
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