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https://www.readbyqxmd.com/read/29667379/lymphogranuloma-venereum-genovar-l2b-concomitantly-with-syphilis-and-hepatitis-c-in-a-male-patient-in-poland-%C3%A2-case-report
#1
Agnieszka Beata Serwin, Marta Koper, Magnus Unemo
We describe the first case of lymphogranuloma venereum (LGV) in Poland, with inguino-femoral lymphadenopathy, diagnosed and successfully treated according to the 2013 European LGV guideline. Chlamydia trachomatis genovar L2b, mainly responsible for the ongoing LGV epidemics among men who have sex with men (MSM) in Western European countries, was confirmed. The case also verified that co-infections with other sexually transmitted infections (syphilis and hepatitis C virus) are frequent in MSM LGV patients, as well as the very large difficulties with contact tracing for these patients...
2018: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29662931/ulcerative-colitis-are-we-neglecting-its-progressive-character
#2
Paulo Massinha, Francisco Portela, Sara Campos, Gabriela Duque, Manuela Ferreira, Sofia Mendes, Ana Margarida Ferreira, Carlos Sofia, Luís Tomé
Introduction: Ulcerative colitis (UC) is a chronic disease but its progressive character, with structural damage, is insufficiently studied. Objectives: To analyze a group of patients without referral bias, regarding its clinical course, the morphological damage, and functional status. Methods: We evaluated UC patients diagnosed between January 1, 2000 and December 31, 2004, living in the direct referral area of the hospital and determined the medication use, colectomy rate, structural damage ("lead pipe," stenosis, pseudopolyps, fibrous bridges), and anorectal function (prospective evaluation with the Cleveland Clinic Incontinence Score [CCIS] and the Fecal Incontinence Quality of Life Scale)...
March 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29629351/evaluation-of-prophylactic-and-therapeutic-effects-of-ruscogenin-on-acute-radiation-proctitis-an-experimental-rat-model
#3
Erkan Yavuz, Onur Olgac Karagulle, Gulcin Ercan, Atilla Celik, Hakan Yigitbas, Busra Yaprak Bayrak, Rumeysa Tartar, Ramazan Kusaslan, Yuksel Altinel, Osman Bilgin Gulcicek
Purpose: Radiation proctitis (RP) is inflammation and damage to the rectum, manifested secondary to ionizing radiation utilized for treatment. In this study, we evaluated the anti-inflammatory therapeutical and protective effects of ruscogenin in a model of acute RP. Methods: Thirty-two Sprague-Dawley rats were divided into 4 groups (n = 8) as sham, control, treatment, and prophylaxis groups. Prophylaxis group and treatment group were dosed ruscogenin by oral gavage for 14 days pre- and postradiation...
April 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29629057/etiology-of-gastrointestinal-bleeding-in-children-referred-to-pediatric-wards-of-mashhad-hospitals-iran
#4
Seyed Ali Jafari, Mohammad Ali Kiani, Hamid Reza Kianifar, Mohammad Mansooripour, Elahe Heidari, Maryam Khalesi
Background: Gastrointestinal (GI) bleeding, which has several clinical manifestation and origins, is known as one of the most life-threatening events in children. Several etiologies have been suggested for GI bleeding. Objective: To determine the most important causes of GI bleeding in children referred to Ghaem Hospital and Dr. Sheikh Hospital, Mashhad, Iran. Methods: In this cross-sectional study, after obtaining written informed consent of their parents, 113 patients aging from newborn infants to 18-year-old children with GI bleeding admitted to Ghaem Hospital and Dr...
February 2018: Electronic Physician
https://www.readbyqxmd.com/read/29621870/preoperative-short-course-radiotherapy-with-concurrent-and-consolidation-chemotherapies-followed-by-delayed-surgery-in-locally-advanced-rectal-cancer-preliminary-results
#5
Mahdi Aghili, Sarvazad Sotoudeh, Reza Ghalehtaki, Mohammad Babaei, Borna Farazmand, Mohammad-Sadegh Fazeli, Amir Keshvari, Peiman Haddad, Farshid Farhan
PURPOSE: This study aimed to assess complications and outcomes of a new approach, that is, combining short course radiotherapy (SRT), concurrent and consolidative chemotherapies, and delayed surgery. MATERIALS AND METHODS: In this single arm phase II prospective clinical trial, patients with T3-4 or N+ M0 rectal adenocarcinoma were enrolled. Patients who received induction chemotherapy or previous pelvic radiotherapy were excluded. Study protocol consisted of three-dimensional conformal SRT (25 Gy in 5 fractions in 1 week) with concurrent and consolidation chemotherapies including capecitabine and oxaliplatin...
March 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29608959/clinical-diagnostic-and-therapeutic-aspects-of-221-consecutive-anorectal-chlamydia-trachomatis-and-neisseria-gonorrhoeae-sexually-transmitted-infections-among-men-who-have-sex-with-men
#6
J Lourtet Hascoet, M Dahoun, M Cohen, E Pommaret, B Pilmis, N Lemarchand, A Mizrahi, M Aubert, V de Parades, A Le Monnier
OBJECTIVES: Proctitis caused by Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are known as sexually transmitted infections (STI). This study describes their clinical, diagnostic and therapeutic aspects. METHODS: Between 01/2013-03/2015, all MSM consulting for proctitis at proctology Institute-Saint-Joseph's Hospital, Paris, were included. Demographic, past-medical history, STI status and medical treatment were collected. Detection of CT/NG was performed by Transcription-Mediated Amplification (TMA) and antimicrobial susceptibilities for Ng by agar diffusion method...
March 30, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29588844/tacrolimus-therapy-in-moderate-to-subacute-ulcerative-proctocolitis-a-large-single-centre-cohort-study
#7
Aamir Saifuddin, Adam Harris
Objective: To explore the 'real world' effectiveness of tacrolimus therapy for refractory ulcerative proctocolitis (UC). Design: Retrospective cohort study using prospectively collated clinical data. Setting: A single district general hospital in Kent, UK. Clinical decisions and regular monitoring were undertaken by a single expert in inflammatory bowel disease. Patients: All patients started on tacrolimus between January 2010 and August 2016 at Tunbridge Wells Hospital...
April 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29588836/emerging-role-of-thalidomide-in-the-treatment-of-gastrointestinal-bleeding
#8
REVIEW
Michael McFarlane, Lauren O'Flynn, Rachel Ventre, Benjamin R Disney
Thalidomide was initially synthesised in 1954 and marketed as a sedative and antiemetic for morning sickness. It was withdrawn in 1961 due to the realisation that it was teratogenic with over 10 000 children born with congenital abnormalities. Since then it has been used for treatment of dermatological and oncological conditions, including myeloma. In 1994, it was found to have a potent antiangiogenic effect via downregulation of vascular endothelial growth factor (VEGF). This has led to its use in gastrointestinal bleeding, as vascular abnormalities such as angiodysplasia have been found to have elevated VEGF levels...
April 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29572605/inflammatory-bowel-disease-across-the-age-continuum-similarity-and-disparity
#9
Amey Dilip Sonavane, Pratibha Sonawane, Deepak N Amarapurkar
OBJECTIVES: To identify similarities and differences between the pediatric-onset and adult-onset Inflammatory Bowel Disease (IBD) based cohorts and further characterize the pediatric cohort. METHODS: A retrospective analysis of pediatric patients attending the tertiary referral care gastroenterology center from 2004 to 2016 was conducted. All the patients were clinically evaluated, investigated and followed up at the centre. RESULTS: Sixty five patients with pediatric IBD were compared with 216 patients with adult-onset IBD...
March 23, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29567823/cervical-cancer-in-ethiopia-the-effect-of-adherence-to-radiotherapy-on-survival
#10
Ulrike Moelle, Assefa Mathewos, Abreha Aynalem, Tigeneh Wondemagegnehu, Bekuretsion Yonas, Matthias Begoihn, Adamu Addissie, Susanne Unverzagt, Ahmedin Jemal, Christoph Thomssen, Dirk Vordermark, Eva J Kantelhardt
BACKGROUND: Discontinuation of radiotherapy (RT) for cervical cancer (CC) in sub-Saharan Africa is common because of patient- and health service-related reasons. This analysis describes toxicities and the effect of adherence on survival. MATERIALS AND METHODS: A total of 788 patients with CC (2008-2012) who received RT at Addis Ababa University Hospital were included. External beam RT without brachytherapy was performed according to local guidelines. We previously described survival and prognostic factors...
March 22, 2018: Oncologist
https://www.readbyqxmd.com/read/29564671/role-of-positron-emission-tomography-in-assessing-disease-activity-in-ulcerative-colitis-comparison-with-biomarkers
#11
Neha Berry, Saroj Kant Sinha, Anish Bhattacharya, K K Prasad, Chetana Vaishnavi, Kim Vaiphei, Jayanta Samanta, Raghavendra Prasada, Narendra Dhaka, Rakesh Kochhar
BACKGROUND: Disease activity in ulcerative colitis (UC) is best assessed clinically by Mayo score. 18-Fluorodeoxyglucose positron emission tomography-computerized tomography (FDG PET-CT) is a noninvasive imaging technique to assess extent, disease activity and response to treatment of UC, especially in high risk population or patients unwilling for endoscopy. AIMS: We conducted a prospective observational study with the aim of assessing and correlating UC disease activity by clinical criteria, endoscopy, histology, serum and fecal biomarkers, and FDG PET-CT...
March 21, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29560668/lymphogranuloma-venereum-among-patients-presenting-at-the-hiv-sti-clinic-in-antwerp-belgium-a-case-series
#12
Ludwig Apers, Eric Florence, Tania Crucitti, Nabila Anwar
Objective of this study was to describe the patient characteristics and clinical presentation of laboratory confirmed lymphogranuloma venereum (LGV) cases, diagnosed at the Institute of Tropical Medicine (ITM), Antwerp, Belgium. Demographic and biomedical characteristics of all patients with chlamydia-positive sample results were retrieved for the years 2013 and 2014. Samples were obtained from both symptomatic and asymptomatic patients who consulted at the HIV/STI clinic. Fifty four patients with laboratory confirmed LGV were detected among 3885 nucleic acid amplification tests (NAATs) performed for the detection of chlamydia during the two years under review...
July 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29556393/neoadjuvant-brachytherapy-and-chemotherapy-followed-by-radical-surgery-for-stage-ib2-and-iia-cervical-cancer-a-retrospective-comparison-with-chemoirradiation
#13
Yaomei Ma, Guiling Zhao, Ji Qi, Peisong Sun, Caiyan Liu, Pengpeng Qu, Karen K L Chan
The aim of the present study was to assess the immediate and long-term results of preoperative brachytherapy and chemotherapy followed by radical surgery compared with those of standard chemoirradiation in patients with stage IB2-IIA cervical cancer. The medical records of 70 patients with stage IB2 and IIA cervical cancer who were treated between June 2006 and June 2010 were reviewed. The patients received either standard chemoirradiation (CRT) treatment (n=20) or neoadjuvant brachytherapy with one cycle of chemotherapy followed by radical hysterectomy [operation (OT) group; n=50]...
April 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29554287/intensity-modulated-radiotherapy-versus-three-dimensional-conformal-radiotherapy-in-rectal-cancer-treated-with-neoadjuvant-concurrent-chemoradiation-a-meta-analysis-and-pooled-analysis-of-acute-toxicity
#14
Chan Woo Wee, Hyun-Cheol Kang, Hong-Gyun Wu, Eui Kyu Chie, Noorie Choi, Jong Min Park, Jung-In Kim, Chun-Ming Huang, Jaw-Yuan Wang, Shu Y Ng, Karyn A Goodman
Background: To compare the acute gastrointestinal (GI) and genitourinary (GU) toxicity profiles between intensity-modulated radiotherapy (IMRT) and three-dimensional conformal radiotherapy (3DCRT) in rectal cancer patients treated with neoadjuvant chemoradiation (NCRT) using meta-analysis and pooled-analysis from published articles. Methods: Literature search was performed in PubMed and EMBASE from inception to March 2017. The odd ratios (ORs) were calculated and random effects model was used for meta-analysis...
March 15, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29553338/chlamydia-trachomatis-in-cervical-lymph-node-of-man-with-lymphogranuloma-venereum-croatia-2014-1
#15
Branimir Gjurašin, Snježana Židovec Lepej, Michelle J Cole, Rachel Pitt, Josip Begovac
We report an HIV-infected person who was treated for lymphogranuloma venereum cervical lymphadenopathy and proctitis in Croatia in 2014. Infection with a variant L2b genovar of Chlamydia trachomatis was detected in a cervical lymph node aspirate. A prolonged course of doxycycline was required to cure the infection.
April 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29545442/unusual-case-of-a-rectal-tumour
#16
Maryam Alfa-Wali, Samantha Muktar, Dimitrios Pissas, Ceri Slater
A 48-year-old man presented as an emergency with a 3-week history of rectal bleeding. Examination of his rectum revealed a circumferential tumour, 2 cm from the anal verge. An MRI scan reported a locally infiltrative mid-lower rectal tumour staged as T3d/T4 N2 MX. A colonoscopy revealed appearances of severe proctitis and biopsies did not show any evidence of dysplasia or malignancy. The patient was discussed at the regional colorectal cancer multidisciplinary team meeting with a management plan for neoadjuvant chemoradiotherapy following repeat biopsies, which were again negative for malignancy...
March 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29513173/lymphogranuloma-venereum-among-patients-presenting-at-the-hiv-sti-clinic-in-antwerp-belgium-a-case-series
#17
L Apers, E Florence, T Crucitti, N Anwar
Objective of this study was to describe the patient characteristics and clinical presentation of laboratory confirmed lymphogranuloma venereum (LGV) cases, diagnosed at the Institute of Tropical Medicine (ITM), Antwerp, Belgium. Demographic and biomedical characteristics of all patients with chlamydia-positive sample results were retrieved for the years 2013 and 2014. Samples were obtained from both symptomatic and asymptomatic patients who consulted at the HIV/STI clinic. Fifty four patients with laboratory confirmed LGV were detected among 3885 nucleic acid amplification tests (NAATs) performed for the detection of chlamydia during the two years under review...
July 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29465653/clinical-characteristics-of-anorectal-mycoplasma-genitalium-infection-and-microbial-cure-in-men-who-have-sex-with-men
#18
Jason J Ong, Ei Aung, Tim R H Read, Christopher K Fairley, Suzanne M Garland, Gerald Murray, Marcus Y Chen, Eric P F Chow, Catriona S Bradshaw
BACKGROUND: We report clinical characteristics of proctitis caused solely by Mycoplasma genitalium(MG), compared with chlamydia and gonococcus. We determined the proportions cured with first-line (azithromycin) and second-line antimicrobials (moxifloxacin, pristinamycin). METHODS: 166 patients attending Melbourne Sexual Health Centre from 2012 to 2016 with symptoms of proctitis were tested for MG, Chlamydia trachomatis and Neisseria gonorrhoeae. Demographic characteristics, sexual behaviours, clinical symptoms and signs were recorded...
January 18, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29462845/a-comparison-of-the-microbial-community-structure-between-inflamed-and-non-inflamed-sites-in-patients-with-ulcerative-colitis
#19
Atsushi Hirano, Junji Umeno, Yasuharu Okamoto, Hiroki Shibata, Yoshitoshi Ogura, Tomohiko Moriyama, Takehiro Torisu, Shin Fujioka, Yuta Fuyuno, Yutaka Kawarabayasi, Takayuki Matsumoto, Takanari Kitazono, Motohiro Esaki
BACKGROUND AND AIM: The gut microbiota is suggested to play an important role in the pathogenesis of ulcerative colitis (UC). However, inter-individual and spatial variations hamper the identification of UC-related changes. We thus investigated paired mucosa-associated microbiota obtained from both inflamed and non-inflamed sites of UC patients and corresponding sites of non-IBD controls. METHODS: Mucosal biopsies of both inflamed and non-inflamed sites were obtained from 14 patients with active UC of the left-sided or proctitis type...
February 20, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29457211/acetarsol-suppositories-effective-treatment-for-refractory-proctitis-in-a-cohort-of-patients-with-inflammatory-bowel-disease
#20
Christopher J Kiely, Angela Clark, Joya Bhattacharyya, Gordon W Moran, James C Lee, Miles Parkes
BACKGROUND: Management of proctitis refractory to conventional therapies presents a common clinical problem. The use of acetarsol suppositories, which are derived from organic arsenic, was first described in 1965. Data concerning clinical efficacy and tolerability are very limited. AIM: To examine the efficacy of acetarsol suppositories for the treatment of refractory proctitis. METHODS: A retrospective analysis was performed on patients with inflammatory bowel disease treated with acetarsol suppositories between 2008 and 2014 at Addenbrooke's Hospital, Cambridge, United Kingdom...
February 19, 2018: Digestive Diseases and Sciences
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