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Cognitive Therapy

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https://www.readbyqxmd.com/read/29235884/cost-per-successfully-treated-patient-for-vortioxetine-versus-duloxetine-in-adults-with-major-depressive-disorder-an-analysis-of-the-complete-symptoms-of-depression-and-functional-outcome
#1
Michael Cronquist Christensen, Vicki Munro
OBJECTIVE: To determine the cost-effectiveness of vortioxetine versus duloxetine in adults with moderate to severe major depressive disorder (MDD) in Norway using a definition of a successfully treated patient (STP) that incorporates improvement in both mood symptoms and functional capacity. METHODS: Using the population of patients who completed the 8-week CONNECT study, the cost-effectiveness of vortioxetine (n = 168) (10-20 mg/day) versus duloxetine (n = 176) (60 mg/day) was investigated for the treatment of adults in Norway with moderate to severe MDD and self-reported cognitive dysfunction over an 8-week treatment period...
December 13, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29235615/-music-therapy-as-a-non-pharmacological-treatment-in-alzheimer-s-disease-a-systematic-review
#2
N Garcia-Casares, R M Moreno-Leiva, J A Garcia-Arnes
INTRODUCTION: Alzheimer's disease (AD) is a neurodegenerative disease which involves, among other manifestations, a progressive deterioration of memory and language, as well as behavioral disorders. In addition to non-curative pharmacological therapies, for the last years, music therapy has been developed as an effective non-pharmacological therapy in order to relieve many of these manifestations. AIM: To analyze the recent scientific evidence about the effect of music therapy on cognitive and behavioral symptoms in patients with AD...
December 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/29235507/blood-brain-glucose-transfer-in-alzheimer-s-disease-effect-of-glp-1-analog-treatment
#3
Michael Gejl, Birgitte Brock, Lærke Egefjord, Kim Vang, Jørgen Rungby, Albert Gjedde
There are fewer than normal glucose transporters at the blood-brain barrier (BBB) in Alzheimer's disease (AD). When reduced expression of transporters aggravates the symptoms of AD, the transporters become a potential target of therapy. The incretin hormone GLP-1 prevents the decline of cerebral metabolic rate for glucose (CMRglc) in AD, and GLP-1 may serve to raise transporter numbers. We hypothesized that the GLP-1 analog liraglutide would prevent the decline of CMRglc in AD by raising blood-brain glucose transfer, depending on the duration of disease...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29234918/patients-with-dementia-in-acute-care-hospitals-a%C3%A2-cross-sectional-study-of-physicians-experiences-and-attitudes
#4
Lena Helm, Katrin Balzer, Anja Behncke, Nora Eisemann, Sascha Köpke
BACKGROUND: Patients with dementia (PwD) are a vulnerable group and caring for these patients in acute care hospitals is challenging. Structural conditions and standardized treatment procedures in hospitals often do not correspond to the needs of this patient group. Physicians may not be well prepared for caring for PwD. OBJECTIVE: This study aimed to ascertain physicians' experiences and attitudes in caring for PwD or cognitive disorders and their subjective workload...
December 12, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29234826/mental-health-impact-of-social-capital-interventions-a-systematic-review
#5
Elaine C Flores, Daniela C Fuhr, Angela M Bayer, Andres G Lescano, Nicki Thorogood, Victoria Simms
PURPOSE: Mental disorders are a major contributor to the global burden of disease and disability, and can be extremely costly at both individual and community level. Social capital, (SC) defined as an individual's social relationships and participation in community networks, may lower the risk of mental disorders while increasing resilience capacity, adaptation and recovery. SC interventions may be a cost-effective way of preventing and ameliorating these conditions. However, the impact of these SC interventions on mental health still needs research...
December 12, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29234813/hormone-therapy-for-the-primary-prevention-of-chronic-conditions-in-postmenopausal-women-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#6
Gerald Gartlehner, Sheila V Patel, Cynthia Feltner, Rachel Palmieri Weber, Rachel Long, Kelly Mullican, Erin Boland, Linda Lux, Meera Viswanathan
Importance: Postmenopausal status coincides with increased risks for chronic conditions such as heart disease, osteoporosis, cognitive impairment, or some types of cancers. Previously, hormone therapy was used for the primary prevention of these chronic conditions. Objective: To update evidence for the US Preventive Services Task Force on the benefits and harms of hormone therapy in reducing risks for chronic conditions. Data Sources: MEDLINE, Cochrane Library, EMBASE, and trial registries from June 1, 2011, through August 1, 2016...
December 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29234567/nerve-entrapment-in-the-hip-region-current-concepts-review
#7
RobRoy Martin, Hal David Martin, Benjamin R Kivlan
The purpose of this clinical commentary is to review the anatomy, etiology, evaluation, and treatment techniques for nerve entrapments of the hip region. Nerve entrapment can occur around musculotendinous, osseous, and ligamentous structures because of the potential for increased strain and compression on the peripheral nerve at those sites. The sequela of localized trauma may also result in nerve entrapment if normal nerve gliding is prevented. Nerve entrapment can be difficult to diagnose because patient complaints may be similar to and coexist with other musculoskeletal conditions in the hip and pelvic region...
December 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29234436/fraction-n-butanol-of-radix-notoginseng-protects-pc12-cells-from-a%C3%AE-25-35-induced-cytotoxicity-and-alleviates-cognitive-deficits-in-samp8-mice-by-attenuating-oxidative-stress-and-a%C3%AE-accumulation
#8
Jin-Lan Huang, Ying-Qin Feng, Li-Ru Bai, Mei-Chun Qin, Zhe-Hao Xu, Zhao-Rong Liu, Wen-Bing Chen, Deng-Pan Wu, Zhen-Guo Zhong
Chinese medicine has been used for Alzheimer's disease (AD) treatment for thousands of years with more effective and fewer side effects. Therefore, developing effective potential candidates from Chinese medicine against AD would be considered as critical and efficient therapy for AD treatment. This study was designed to evaluate the neuronal protective effect of fraction n-butanol (NB) of Radix Notoginseng on Aβ25-35-induced PC12 cells, explore the effect of the tested fraction on spatial learning and memory, and characterize the impacts of fraction NB on antioxidant enzymes, Aβ production, and APP and BACE1 expressions...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234089/impact-of-treatment-on-resting-cerebral-blood-flow-and-metabolism-in-obsessive-compulsive-disorder-a-meta-analysis
#9
A L van der Straten, D Denys, G A van Wingen
Neurobiological models of obsessive-compulsive disorder (OCD) posit that its clinical symptoms such as repetitive thoughts and behaviors are related to hyperactivity in the cortico-striato-thalamo-cortical (CSTC) circuit. Small scale neuroimaging studies have shown that treatment of OCD is associated with reduced activity across different brain structures within this circuitry. We performed the first meta-analysis of positron emission tomography (PET) and single photon emission computed tomography (SPECT) studies that investigated cerebral blood flow or glucose metabolism in patients with OCD before and after pharmacological or psychological treatment...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233555/human-neural-stem-cell-transplantation-rescues-functional-deficits-in-r6-2-and-q140-huntington-s-disease-mice
#10
Jack C Reidling, Aroa Relaño-Ginés, Sandra M Holley, Joseph Ochaba, Cindy Moore, Brian Fury, Alice Lau, Andrew H Tran, Sylvia Yeung, Delaram Salamati, Chunni Zhu, Asa Hatami, Carlos Cepeda, Joshua A Barry, Talia Kamdjou, Alvin King, Dane Coleal-Bergum, Nicholas R Franich, Frank M LaFerla, Joan S Steffan, Mathew Blurton-Jones, Charles K Meshul, Gerhard Bauer, Michael S Levine, Marie-Francoise Chesselet, Leslie M Thompson
Huntington's disease (HD) is an inherited neurodegenerative disorder with no disease-modifying treatment. Expansion of the glutamine-encoding repeat in the Huntingtin (HTT) gene causes broad effects that are a challenge for single treatment strategies. Strategies based on human stem cells offer a promising option. We evaluated efficacy of transplanting a good manufacturing practice (GMP)-grade human embryonic stem cell-derived neural stem cell (hNSC) line into striatum of HD modeled mice. In HD fragment model R6/2 mice, transplants improve motor deficits, rescue synaptic alterations, and are contacted by nerve terminals from mouse cells...
December 6, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29233169/an-evidence-based-gamified-mhealth-intervention-for-overweight-young-adults-with-maladaptive-eating-habits-study-protocol-for-a-randomized-controlled-trial
#11
Ioana R Podina, Liviu A Fodor, Ana Cosmoiu, Rareș Boian
BACKGROUND: Cognitive behavior therapy (CBT) is the first-line of treatment for overweight and obesity patients whose problems originate in maladaptive eating habits (e.g., emotional eating). However, in-person CBT is currently difficult to access by large segments of the population. The proposed SIGMA intervention (i.e., the Self-help, Integrated, and Gamified Mobile-phone Application) is a mHealth intervention based on CBT principles. It specifically targets overweight young adults with underlying maladaptive behaviors and cognitions regarding food...
December 12, 2017: Trials
https://www.readbyqxmd.com/read/29233071/biomarkers-of-stroke-recovery-consensus-based-core-recommendations-from-the-stroke-recovery-and-rehabilitation-roundtable
#12
Lara A Boyd, Kathryn S Hayward, Nick S Ward, Cathy M Stinear, Charlotte Rosso, Rebecca J Fisher, Alexandre R Carter, Alex P Leff, David A Copland, Leeanne M Carey, Leonardo G Cohen, D Michele Basso, Jane M Maguire, Steven C Cramer
The most difficult clinical questions in stroke rehabilitation are "What is this patient's potential for recovery?" and "What is the best rehabilitation strategy for this person, given her/his clinical profile?" Without answers to these questions, clinicians struggle to make decisions regarding the content and focus of therapy, and researchers design studies that inadvertently mix participants who have a high likelihood of responding with those who do not. Developing and implementing biomarkers that distinguish patient subgroups will help address these issues and unravel the factors important to the recovery process...
October 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29232559/cilostazol-a-phosphodiesterase-3-inhibitor-activates-proteasome-proteolysis-and-attenuates-tauopathy-and-cognitive-decline
#13
Ari W Schaler, Natura Myeku
Alzheimer's disease and several variants of frontotemporal degeneration including progressive supranuclear palsy and corticobasal degeneration are characterized by the accumulation of abnormal tau protein into aggregates. Most proteins, including tau, are degraded via the ubiquitin proteasome system, but when abnormal tau accumulates, the function of 26S proteasomes is downregulated. The negative effect of tau aggregates on the function of the proteasome can have deleterious consequences on protein homeostasis and disease progression...
November 23, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29232539/how-to-identify-and-manage-cognitive-dysfunction-after-breast-cancer-treatment
#14
Marie Lange, Florence Joly
Attention and memory dysfunction is a common complaint among patients with breast cancer that can be reported during and up to several years after treatment. It can negatively affect patients' quality of life and their ability to work. This phenomenon has mainly been studied in patients with breast cancer who are treated with adjuvant chemotherapy. Women describe concentration problems and difficulties with word finding, multitasking, or remembering new information, as well as more effort and time needed to accomplish these tasks...
December 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29232526/prevention-of-childhood-obesity-in-child-health-services-follow-up-of-the-primrose-trial
#15
Johanna Enö Persson, Benjamin Bohman, Per Tynelius, Finn Rasmussen, Ata Ghaderi
BACKGROUND: Childhood obesity is an urgent public health concern, and there's a need for long-term, high-quality, primary prevention trials targeting parents of young children. The aim of the current study was to evaluate the long-term effect of a parental support program based on motivational interviewing (MI). METHODS: A cluster randomized controlled trial was carried out in eight Swedish counties. Participating families (N = 1355) were enrolled when the child was 9 months old, and participated in nine sessions during ∼39 months...
December 12, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/29232279/association-of-chronic-obstructive-pulmonary-disease-with-mild-cognitive-impairment-and-dementia
#16
Krishna Kakkera, Kalpana P Padala, Maneetha Kodali, Prasad R Padala
PURPOSE OF REVIEW: As age expectancy increases, both dementia and chronic obstructive pulmonary disease (COPD) have become more prevalent. Dementia and COPD together, however, occur more commonly than would be predicted from the incidence of either alone, suggesting a link between these two common senescent diseases. The purpose of this article is to review the extant literature and report findings in a clinically meaningful manner. We will look at the level of evidence, the risk factors for co-occurrence of the two diseases and the differential effects upon cognitive domains in the population with dementia and COPD...
December 9, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29231329/-definition-of-ashi-point-from-the-view-of-linguistics
#17
Shan Jiang, Jingsheng Zhao
The definition of ashi point has not been unified yet till now. Likewise, the precise explanation on its connotation has always been an elusive question in acupuncture theory. By collecting diverse definitions on ashi point in the textbooks of Acupuncture and Moxibustion, dictionaries and term standards, several rational elements in definitions with consensus were screened. With the assistance of two important theories of cognitive linguistics, such as figure-ground theory and distance iconicity theory, the concept of ashi point was newly defined...
January 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231139/catechol-o-methyltransferase-cognition-and-alzheimer-s-disease
#18
Matea Nikolac Perkovic, Dubravka Svob Strac, Lucija Tudor, Marcela Konjevod, Gordana Nedic Erjavec, Nela Pivac
OBJECTIVE: Cognition is a complex trait representing a set of all mental abilities and processes related to knowledge. Although diverse brain regions are involved, most cognitive processes appear to engage cortical regions. The activity of dopaminergic neurons in prefrontal cortex represents a biological substrate underlying cognitive functions. Alzheimer's disease (AD) is the most frequent dementia associated with cognitive impairments. Cognitive impairment in AD starts slow with discrete deterioration in memory, language, thinking and reasoning, but it progresses into more severe and debilitating cognitive dysfunction...
December 11, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29230723/erratum-to-cognitive-behavioral-therapy
#19
Hong An, Ri-Hui He, Yun-Rong Zheng, Ran Tao
No abstract text is available yet for this article.
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29230564/adsorptive-filtration-systems-for-effective-removal-of-blood-amyloid-%C3%AE-a-potential-therapy-for-alzheimer-s-disease
#20
Nobuya Kitaguchi, Kazunori Kawaguchi, Kazunori Yamazaki, Hiroshi Kawachi, Miwa Sakata, Megumi Kaneko, Masao Kato, Kazuyoshi Sakai, Norimi Ohashi, Midori Hasegawa, Yoshiyuki Hiki, Yukio Yuzawa
Accumulation of amyloid-β protein (Aβ) in the brain causes cognitive impairment in Alzheimer's disease. We hypothesized that an extracorporeal system that rapidly removed Aβ from the blood may accelerate Aβ drainage from the brain. We previously reported that dialyzers remove blood Aβs effectively, mainly by adsorption on the inner surfaces of the hollow fibers, resulting in lower Aβ accumulation in the brains of patients undergoing hemodialysis than the controls without hemodialysis. The aim of the present study was to create a more convenient and effective blood Aβ removal system using adsorptive filtration, in which the filtrate returned to the body...
December 11, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
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