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Cognitive Therapy

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https://www.readbyqxmd.com/read/29454255/effects-of-adjunctive-eslicarbazepine-acetate-on-neurocognitive-functioning-in-children-with-refractory-focal-onset-seizures
#1
Sergiusz Jóźwiak, P Veggiotti, J Moreira, H Gama, F Rocha, P Soares-da-Silva
PURPOSE: This was a phase-II, randomized, double-blind (DB), placebo-controlled study aimed to evaluate neurocognitive effects of eslicarbazepine acetate (ESL) as adjunctive therapy in pediatric patients with refractory focal-onset seizures (FOS). METHODS: Children (6-16years old) with FOS were randomized (2:1) to ESL or placebo. Treatment started at 10mg/kg/day, was up-titrated up to 30mg/kg/day (target dose), and maintained for 8weeks, followed by one-year open-label follow-up...
February 13, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29454023/interaction-between-hypothermia-and-delayed-mesenchymal-stem-cell-therapy-in-neonatal-hypoxic-ischemic-brain-injury
#2
Josephine Herz, Christian Köster, Barbara S Reinboth, Mark Dzietko, Wiebke Hansen, Hemmen Sabir, Cindy van Velthoven, Ivo Bendix, Ursula Felderhoff-Müser
Acute hypothermia treatment (HT) is the only clinically established intervention following neonatal hypoxic-ischemic brain injury. However, almost half of all cooled infants still die or suffer from long-lasting neurological impairments. Regenerative therapies, such as mesenchymal stem cells (MSC) appear promising as adjuvant therapy. In the present study, we hypothesized that HT combined with delayed MSC therapy results in augmented protection, improving long-term neurological outcome. Postnatal day 9 (P9) C57BL/6 mice were exposed to hypoxia-ischemia followed by 4 hours HT...
February 14, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29453933/myt1l-induced-direct-reprogramming-of-pericytes-into-cholinergic-neurons
#3
Xing-Guang Liang, Chao Tan, Cheng-Kun Wang, Rong-Rong Tao, Yu-Jie Huang, Kui-Fen Ma, Kohji Fukunaga, Ming-Zhu Huang, Feng Han
OBJECTIVE: The cholinergic deficit is thought to underlie progressed cognitive decline in Alzheimer Disease. The lineage reprogramming of somatic cells into cholinergic neurons may provide strategies toward cell-based therapy of neurodegenerative diseases. METHODS AND RESULTS: Here, we found that a combination of neuronal transcription factors, including Ascl1, Myt1l, Brn2, Tlx3, and miR124 (5Fs) were capable of directly converting human brain vascular pericytes (HBVPs) into cholinergic neuronal cells...
February 17, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29453745/investigating-the-effectiveness-acceptability-and-impact-on-healthcare-usage-of-providing-a-cognitive-behavioural-based-psychological-therapy-service-for-patients-with-primary-antibody-deficiency
#4
Mari Campbell, Alex Clarke, Andrew Symes, Sarita Workman, Hans Stauss, A David Webster
PURPOSE: Patients with primary antibody deficiency report poorer quality of life and higher rates of anxiety and depression than the general population. Cognitive-behavioral therapy has been shown to be a valuable treatment for patients with other long-term physical health conditions, improving well-being and enabling them to manage their symptoms more effectively. The aim of this project was to establish the feasibility and effectiveness of providing cognitive-behavioral based therapy to patients with primary antibody deficiency...
February 17, 2018: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29453638/effects-of-cpap-therapy-on-cognitive-and-psychomotor-performances-in-patients-with-severe-obstructive-sleep-apnea-a-prospective-1-year-study
#5
Renata Pecotic, Ivana Pavlinac Dodig, Maja Valic, Tea Galic, Linda Lusic Kalcina, Natalija Ivkovic, Zoran Dogas
STUDY OBJECTIVES: We prospectively investigated the effects of continuous positive airway pressure (CPAP) on long-term cognitive and psychomotor performances, and excessive daytime sleepiness in severe obstructive sleep apnea (OSA) patients. METHODS: A total of 40 patients were recruited and 23 patients with severe OSA fully completed the study protocol to investigate the effects of CPAP therapy on psychomotor performance at 1, 3, and 6 months and 1 year following initiation of the therapy...
February 16, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29453604/evaluating-the-impact-of-spirituality-on-the-quality-of-life-anxiety-and-depression-among-patients-with-cancer-an-observational-transversal-study
#6
Emile Abou Chaar, Souheil Hallit, Aline Hajj, Racha Aaraj, Joseph Kattan, Hicham Jabbour, Lydia Rabbaa Khabbaz
OBJECTIVE: Spiritual well-being was found to have some protective effect against end-of life despair in cancer patients. We aimed at assessing the impact of spirituality on the quality of life, depression, and anxiety of Lebanese cancer patients. METHODS: Our observational transversal monocentric study was conducted between January and April 2016 among a convenient sample of 115 Lebanese cancer patients admitted to Hôtel-Dieu de France Hospital (HDF), Beirut-Lebanon...
February 16, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29452980/association-between-smoking-cessation-and-weight-gain-in-treatment-seeking-african-americans
#7
Marcia M Tan, Kolawole S Okuyemi, Ken Resnicow, Noella A Dietz, Michael H Antoni, Monica Webb Hooper
INTRODUCTION: Research has shown that African Americans gain more than average weight after smoking cessation. However, African Americans have been underrepresented in post-cessation weight gain research. The current study examined 1) the pattern of weight gain and 2) the association between smoking status and weight gain in a sample of African Americans seeking smoking cessation treatment. METHODS: Data were drawn from a randomized controlled trial testing the efficacy of a 4-week culturally specific smoking cessation cognitive behavioral therapy (CBT) intervention among African American smokers (N = 342)...
February 3, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29452811/effects-on-adult-cognitive-function-after-neonatal-exposure-to-clinically-relevant-doses-of-ionising-radiation-and-ketamine-in-mice
#8
S Buratovic, B Stenerlöw, S Sundell-Bergman, A Fredriksson, H Viberg, T Gordh, P Eriksson
BACKGROUND: Radiological methods for screening, diagnostics and therapy are frequently used in healthcare. In infants and children, anaesthesia/sedation is often used in these situations to relieve the patients' perception of stress or pain. Both ionising radiation (IR) and ketamine have been shown to induce developmental neurotoxic effects and this study aimed to identify the combined effects of these in a murine model. METHODS: Male mice were exposed to a single dose of ketamine (7...
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29452802/moving-to-human-trials-for-argon-neuroprotection-in-neurological-injury-a-narrative-review
#9
REVIEW
A J Gardner, D K Menon
Despite the global burden of brain injury, neuroprotective agents remain elusive. There are no clinically effective therapies which reduce mortality or improve long-term cognitive outcome. Ventilation could be an easily modifiable variable in resuscitation; gases are relatively simple to administer. Xenon is the prototypic agent of a new generation of experimental treatments which show promise. However, use is hindered by its prohibitive cost and anaesthetic properties. Argon is an attractive option, being cheaper, easy to transport, non-sedating, and mechanistically distinct from xenon...
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29451994/stroop-task-related-brain-activity-in-patients-with-insomnia-changes-after-cognitive-behavioral-therapy-for-insomnia
#10
Jeong Yeon Hwang, Nambeom Kim, Soohyun Kim, Juhyun Park, Jae-Won Choi, Seog Ju Kim, Chang-Ki Kang, Yu Jin Lee
OBJECTIVE/BACKGROUND: In the present study, we compared differences in brain activity during the Stroop task between patients with chronic insomnia disorder (CID) and good sleepers (GS). Furthermore, we evaluated changes in Stroop task-related brain activity after cognitive-behavioral therapy for insomnia (CBT-I). PARTICIPANTS/METHODS: The final analysis included 21 patients with CID and 25 GS. All participants underwent functional magnetic resonance imaging (fMRI) while performing the color-word Stroop task...
February 16, 2018: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/29451967/cognitive-behavioral-therapy-for-anxiety-and-related-disorders-a-meta-analysis-of-randomized-placebo-controlled-trials
#11
REVIEW
Joseph K Carpenter, Leigh A Andrews, Sara M Witcraft, Mark B Powers, Jasper A J Smits, Stefan G Hofmann
The purpose of this study was to examine the efficacy of cognitive behavioral therapy (CBT) for anxiety-related disorders based on randomized placebo-controlled trials. We included 41 studies that randomly assigned patients (N = 2,843) with acute stress disorder, generalized anxiety disorder (GAD), obsessive compulsive disorder (OCD), panic disorder (PD), posttraumatic stress disorder (PTSD), or social anxiety disorder (SAD) to CBT or a psychological or pill placebo condition. Findings demonstrated moderate placebo-controlled effects of CBT on target disorder symptoms (Hedges' g = 0...
February 16, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29451664/update-on-antiphospholipid-antibody-syndrome
#12
Michelle Remião Ugolini Lopes, Adriana Danowski, Andreas Funke, Jozelia Rêgo, Roger Levy, Danieli Castro Oliveira de Andrade
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by antiphospholipid antibodies (aPL) associated with thrombosis and/or pregnancy morbidity. Most APS events are directly related to thrombotic events, which may affect small, medium or large vessels. Other clinical features like thrombocytopenia, nephropathy, cardiac valve disease, cognitive dysfunction and skin ulcers (called non-criteria manifestations) add significant morbidity to this syndrome and represent clinical situations that are challenging...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29451586/virtual-reality-exposure-therapy-for-fear-of-driving-analysis-of-clinical-characteristics-physiological-response-and-sense-of-presence
#13
Rafael T da Costa, Marcele R de Carvalho, Pedro Ribeiro, Antonio E Nardi
OBJECTIVE: To investigate the reactions of women with driving phobia to a therapeutic program of scheduled virtual reality exposure treatment (VRET) sessions. METHODS: The study intervention consisted of a computer game with car-driving scenarios that included several traffic situations. We investigated the participants' sense of presence, subjective distress, and physiological responses during eight virtual-reality exposures. We also evaluated clinical characteristics, driving cognitions, and quality of life in the participants...
February 15, 2018: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29451153/effects-of-plasma-lipids-and-statins-on-cognitive-function
#14
REVIEW
Rui Li, Tian-Jun Wang, Pei-Yuan Lyu, Yang Liu, Wei-Hong Chen, Ming-Yue Fan, Jing Xu
Objective: Dementia is the fourth most common cause of death in developed countries. The relationship between plasma lipids and cognitive function is complex and controversial. Due to the increasing life expectancy of the population, there is an urgent need to control vascular risk factors and to identify therapies to prevent and treat both cognitive impairment and dementia. Here, we reviewed the effects of plasma lipids and statins on cognitive function. Data Sources: We searched the PubMed database for research articles published through November 2017 with key words including "plasma lipids," "hyperlipidemia," "hypercholesterolemia," "statins," and "cognition function...
February 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29450678/predicting-the-effectiveness-of-work-focused-cbt-for-common-mental-disorders-the-influence-of-baseline-self-efficacy-depression-and-anxiety
#15
Veerle Brenninkmeijer, Suzanne E Lagerveld, Roland W B Blonk, Wilmar B Schaufeli, Leoniek D N V Wijngaards-de Meij
Purpose This study examined who benefits most from a cognitive behavioural therapy (CBT)-based intervention that aims to enhance return to work (RTW) among employees who are absent due to common mental disorders (CMDs) (e.g., depression, anxiety, or adjustment disorder). We researched the influence of baseline work-related self-efficacy and mental health (depressive complaints and anxiety) on treatment outcomes of two psychotherapeutic interventions. Methods Using a quasi-experimental design, 12-month follow-up data of 168 employees were collected...
February 15, 2018: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/29450561/cognitive-performance-of-patients-with-chronic-heart-failure-on-sacubitril-valsartan-a-retrospective-cohort-study
#16
R De Vecchis, C Ariano, G Di Biase, M Noutsias
BACKGROUND: Sacubitril, a neprilysin inhibitor in the combination molecule sacubitril/valsartan, slows down degradation of endogenous natriuretic peptides, thereby enhancing their beneficial cardiovascular effects. However, sacubitril might also promote neuronal dysfunction and cognitive impairment in patients with chronic heart failure (CHF) treated with sacubitril/valsartan, due to possible neprilysin inhibition at the level of Central Nervous System. METHODS: A retrospective cohort study was undertaken to detect the effects exerted by sacubitril/valsartan on cognitive function in CHF patients...
February 15, 2018: Herz
https://www.readbyqxmd.com/read/29449879/the-impact-of-cognitive-processing-therapy-on-stigma-among-survivors-of-sexual-violence-in-eastern-democratic-republic-of-congo-results-from-a-cluster-randomized-controlled-trial
#17
S M Murray, J Augustinavicius, D Kaysen, D Rao, L K Murray, K Wachter, J Annan, K Falb, P Bolton, J K Bass
Background: Sexual violence is associated with a multitude of poor physical, emotional, and social outcomes. Despite reports of stigma by sexual violence survivors, limited evidence exists on effective strategies to reduce stigma, particularly in conflict-affected settings. We sought to assess the effect of group Cognitive Processing Therapy (CPT) on stigma and the extent to which stigma might moderate the effectiveness of CPT in treating mental health problems among survivors of sexual violence in the Democratic Republic of Congo...
2018: Conflict and Health
https://www.readbyqxmd.com/read/29449700/imaging-tau-and-amyloid-%C3%AE-proteinopathies-in-alzheimer-disease-and-other-conditions
#18
REVIEW
Victor L Villemagne, Vincent Doré, Samantha C Burnham, Colin L Masters, Christopher C Rowe
Most neurodegenerative disorders are associated with aggregated protein deposits. In the case of Alzheimer disease (AD), extracellular amyloid-β (Aβ) aggregates and intracellular tau neurofibrillary tangles are the two neuropathological hallmarks of the disease. Aβ-PET imaging has already been approved for clinical use and is being used in clinical trials of anti-Aβ therapies both for patient recruitment and as an outcome measure. These studies have shown that Aβ accumulation is a protracted process that can extend for more than 2 decades before the onset of clinical AD...
February 16, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29449278/7t-brain-mrs-in-hiv-infection-correlation-with-cognitive-impairment-and-performance-on-neuropsychological-tests
#19
M Mohamed, P B Barker, R L Skolasky, N Sacktor
BACKGROUND AND PURPOSE: Validated neuroimaging markers of HIV-associated neurocognitive disorder in patients on antiretroviral therapy are urgently needed for clinical trials. The purpose of this study was to explore the relationship between cognitive impairment and brain metabolism in older subjects with HIV infection. It was hypothesized that MR spectroscopy measurements related to neuronal health and function (particularly N -acetylaspartate and glutamate) would be lower in HIV-positive subjects with worse cognitive performance...
February 15, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29449082/multiple-sclerosis-or-inflammatory-cadasil-case-report-and-review-of-the-literature
#20
N Schiess, K Huether, M Szolics, G Agarwal, A W El-Hattab, S Sathe
BACKGROUND: Multiple sclerosis (MS) and CADASIL presenting together is exceedingly rare. As more cases of "inflammatory" CADASIL emerge, diagnostic challenges for clinicians increase. We report an individual with MS and CADASIL presenting with cognitive decline at age 25. She presented with gadolinium enhancing lesions on MRI and inflammatory cerebrospinal fluid raising the question of whether these patients should be given a diagnosis of "inflammatory CADASIL" or both MS and CADASIL...
February 8, 2018: Clinical Neurology and Neurosurgery
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