keyword
MENU ▼
Read by QxMD icon Read
search

Inflammaging

keyword
https://www.readbyqxmd.com/read/27921031/amniotic-epithelial-cells-a-new-tool-to-combat-aging-and-age-related-diseases
#1
Clara Di Germanio, Michel Bernier, Rafael de Cabo, Barbara Barboni
The number of elderly people is growing at an unprecedented rate and this increase of the aging population is expected to have a direct impact on the incidence of age-related diseases and healthcare-associated costs. Thus, it is imperative that new tools are developed to fight and slow age-related diseases. Regenerative medicine is a promising strategy for the maintenance of health and function late in life; however, stem cell-based therapies face several challenges including rejection and tumor transformation...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/27918465/peripheral-inflammatory-parameters-in-late-life-depression-a-systematic-review
#2
REVIEW
Mónica Martínez-Cengotitabengoa, Lucía Carrascón, John T O'Brien, María-José Díaz-Gutiérrez, Cristina Bermúdez-Ampudia, Kenji Sanada, Marta Arrasate, Ana González-Pinto
Depressive disorders appear relatively frequently in older patients, and therefore represent an important disease burden worldwide. Given the high levels of inflammatory parameters found in depressed elderly patients, the "inflammaging" hypothesis is gaining strength. In this systematic review, we summarize current evidence regarding the relationship between inflammatory parameters and late-life depression, with a unique focus on longitudinal studies to guarantee temporality. According to the data summarized in this review, the levels of some proinflammatory parameters-especially interleukin (IL)-8, IL-6, and tumor necrosis factor (TNF)-α-could serve as biomarkers for the future development of depressive symptoms in elderly patients...
December 2, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27917303/mir-146a-is-upregulated-during-retinal-pigment-epithelium-rpe-choroid-aging-in-mice-and-represses-il-6-and-vegf-a-expression-in-rpe-cells
#3
Yi Hao, Qinbo Zhou, Jing Ma, Yun Zhao, Shusheng Wang
PURPOSE: MicroRNA-146a (miR-146a) has been proposed as a marker for age-associated inflammation, or "inflammaging", acting as a negative regulator of cellular senescence and pro-inflammatory signaling pathways. However, the regulation and function of miR-146 during ocular aging remains unclear. Here we propose that miR-146 is regulated during aging of the retina and choroid, and functions in retinal pigment epithelial (RPE) cells to regulate key genes involved in inflammation and angiogenesis...
June 2016: Journal of Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27896034/ficolin-2-inhibitors-are-present-in-sera-after-prolonged-storage-at-80%C3%A2-%C3%A2-c
#4
Kimball Aaron Geno, Richard E Kennedy, Patricia Sawyer, Cynthia J Brown, Moon H Nahm
Ficolins can activate the lectin pathway of the complement system that provides innate immune protection against pathogens, marks host cellular debris for clearance, and promotes inflammation. Baseline inflammation increases with aging in a phenomenon known as "inflammaging." Although IL-6 and C-reactive protein are known to increase with age, contributions of many complement factors, including ficolins, to inflammaging have been little studied. Ficolin-2 is abundant in human serum and can recognize many target structures; therefore, ficolin-2 has potential to contribute to inflammaging...
2016: PeerJ
https://www.readbyqxmd.com/read/27876574/the-emerging-role-of-ecm-crosslinking-in-t-cell-mobility-as-a-hallmark-of-immunosenescence-in-humans
#5
REVIEW
Jean-Francois Moreau, Thomas Pradeu, Andrea GRignolio, Christine Nardini, Filippo Castiglione, Paolo Tieri, Miriam Capri, Stefano Salvioli, Jean-Luc Taupin, Paolo Garagnani, Claudio Franceschi
Immunosenescence is thought to result from cellular aging and to reflect exposure to environmental stressors and antigens, including cytomegalovirus (CMV). However, not all of the features of immunosenescence are consistent with this view, and this has led to the emergence of the sister theory of "inflammaging". The recently discovered diffuse tissue distribution of resident memory T cells (TRM) which don't recirculate, calls these theories into question. These cells account for most T cells residing in barrier epithelia which sit in and travel through the extracellular matrix (ECM)...
November 19, 2016: Ageing Research Reviews
https://www.readbyqxmd.com/read/27861126/gut-microbiota-influences-pathological-angiogenesis-in-obesity-driven-choroidal-neovascularization
#6
Elisabeth Mma Andriessen, Ariel M Wilson, Gaelle Mawambo, Agnieszka Dejda, Khalil Miloudi, Florian Sennlaub, Przemyslaw Sapieha
Age-related macular degeneration in its neovascular form (NV AMD) is the leading cause of vision loss among adults above the age of 60. Epidemiological data suggest that in men, overall abdominal obesity is the second most important environmental risk factor after smoking for progression to late-stage NV AMD To date, the mechanisms that underscore this observation remain ill-defined. Given the impact of high-fat diets on gut microbiota, we investigated whether commensal microbes influence the evolution of AMD Using mouse models of NV AMD, microbiotal transplants, and other paradigms that modify the gut microbiome, we uncoupled weight gain from confounding factors and demonstrate that high-fat diets exacerbate choroidal neovascularization (CNV) by altering gut microbiota...
December 1, 2016: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/27824273/anti-inflammaging-effects-of-lactobacillus-brevis-ow38-in-aged-mice
#7
J-J Jeong, K A Kim, Y-J Hwang, M J Han, D-H Kim
In the present study, lactic acid bacteria (LAB) strains were collected from kimchi and were screened to isolate strains that inhibit lipopolysaccharide (LPS) production by Escherichia coli and p16 expression and nuclear factor-kappa B (NF-κB) activation in LPS-stimulated macrophages. Oral administration of Lactobacillus brevis OW38 (1×10(9) cfu/mouse) to aged mice (male, 18 months old) for 8 weeks reduced the LPS level in colon fluid and blood. In addition, OW38 treatment also reduced the ratio of Firmicutes or Proteobacteria to Bacteroidetes, which was significantly higher in aged mice than in young mice...
November 8, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27803663/environmental-enrichment-modified-epigenetic-mechanisms-in-samp8-mouse-hippocampus-by-reducing-oxidative-stress-and-inflammaging-and-achieving-neuroprotection
#8
Christian Griñan-Ferré, Dolors Puigoriol-Illamola, Verónica Palomera-Ávalos, David Pérez-Cáceres, Júlia Companys-Alemany, Antonio Camins, Daniel Ortuño-Sahagún, M Teresa Rodrigo, Mercè Pallàs
With the increase in life expectancy, aging and age-related cognitive impairments are becoming one of the most important issues for human health. At the same time, it has been shown that epigenetic mechanisms are emerging as universally important factors in life expectancy. The Senescence Accelerated Mouse P8 (SAMP8) strain exhibits age-related deterioration evidenced in learning and memory abilities and is a useful model of neurodegenerative disease. In SAMP8, Environmental Enrichment (EE) increased DNA-methylation levels (5-mC) and reduced hydroxymethylation levels (5-hmC), as well as increased histone H3 and H4 acetylation levels...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27789101/inflammaging-and-garb-aging
#9
REVIEW
Claudio Franceschi, Paolo Garagnani, Giovanni Vitale, Miriam Capri, Stefano Salvioli
'Inflammaging' refers to the chronic, low-grade inflammation that characterizes aging. Inflammaging is macrophage centered, involves several tissues and organs, including the gut microbiota, and is characterized by a complex balance between pro- and anti-inflammatory responses. Based on literature data, we argue that the major source of inflammatory stimuli is represented by endogenous/self, misplaced, or altered molecules resulting from damaged and/or dead cells and organelles (cell debris), recognized by receptors of the innate immune system...
October 24, 2016: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/27738345/friend-or-foe-the-dichotomous-impact-of-t-cells-on-neuro-de-re-generation-during-aging
#10
Brandon Coder, Weikan Wang, Liefeng Wang, Zhongdao Wu, Qichuan Zhuge, Dong-Ming Su
The interaction between T cells and the central nervous system (CNS) in homeostasis and injury has been recognized being both pathogenic (CD4+ T-helper 1 - Th1, Th17 and γδT) and ameliorative (Th2 and regulatory T cells - Tregs). However, in-depth studies aimed to elucidate the precise in the aged microenvironment and the dichotomous role of Tregs have just begun and many aspects remain unclear. This is due, not only to a mutual dependency and reciprocal causation of alterations and diseases between the nervous and T cell immune systems, but also to an inconsistent aging of the two systems, which dynamically changes with CNS injury/recovery and/or aging process...
October 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27702700/sarcopenic-obesity-or-obese-sarcopenia-a-cross-talk-between-age-associated-adipose-tissue-and-skeletal-muscle-inflammation-as-a-main-mechanism-of-the-pathogenesis
#11
REVIEW
Alexander Kalinkovich, Gregory Livshits
Sarcopenia, an age-associated decline in skeletal muscle mass coupled with functional deterioration, may be exacerbated by obesity leading to higher disability, frailty, morbidity and mortality rates. In the combination of sarcopenia and obesity, the state called sarcopenic obesity (SOB), some key age- and obesity-mediated factors and pathways may aggravate sarcopenia. This review will analyze the mechanisms underlying the pathogenesis of SOB. In obese adipose tissue (AT), adipocytes undergo hypertrophy, hyperplasia and activation resulted in accumulation of pro-inflammatory macrophages and other immune cells as well as dysregulated production of various adipokines that together with senescent cells and the immune cell-released cytokines and chemokines create a local pro-inflammatory status...
October 1, 2016: Ageing Research Reviews
https://www.readbyqxmd.com/read/27595500/aging-of-the-immune-system-focus-on-inflammation-and-vaccination
#12
Marcello Pinti, Victor Appay, Judith Campisi, Daniela Frasca, Tamas Fülöp, Delphine Sauce, Anis Larbi, Birgit Weinberger, Andrea Cossarizza
Major advances in preventing, delaying, or curing individual pathologies are responsible for an increasingly long life span in the developed parts of our planet, and indeed reaching eight to nine decades of life is nowadays extremely frequent. However, medical and sanitary advances have not prevented or delayed the underlying cause of the disparate pathologies occurring in the elderly: aging itself. The identification of the basis of the aging processes that drives the multiple pathologies and loss of function typical of older individuals is a major challenge in current aging research...
October 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27595269/age-related-alterations-in-signaling-pathways-in-articular-chondrocytes-implications-for-the-pathogenesis-and-progression-of-osteoarthritis-a-mini-review
#13
Peter van der Kraan, Csaba Matta, Ali Mobasheri
Musculoskeletal conditions are a major burden on individuals, healthcare systems, and social care systems throughout the world, with indirect costs having a predominant economic impact. Aging is a major contributing factor to the development and progression of arthritic and musculoskeletal diseases. Indeed, aging and inflammation (often referred to as 'inflammaging') are critical risk factors for the development of osteoarthritis (OA), which is one of the most common forms of joint disease. The term 'chondrosenescence' has recently been introduced to define the age-dependent deterioration of chondrocyte function and how it undermines cartilage function in OA...
September 6, 2016: Gerontology
https://www.readbyqxmd.com/read/27581584/inflammaging-and-skeletal-muscle-can-protein-intake-make-a-difference
#14
Dimitrios Draganidis, Leonidas G Karagounis, Ioannis Athanailidis, Athanasios Chatzinikolaou, Athanasios Z Jamurtas, Ioannis G Fatouros
Inflammaging is the chronic low-grade inflammatory state present in the elderly, characterized by increased systemic concentrations of proinflammatory cytokines. It has been shown that inflammaging increases the risk of pathologic conditions and age-related diseases, and that it also has been associated with increased skeletal muscle wasting, strength loss, and functional impairments. Experimental evidence suggests that the increased concentrations of proinflammatory cytokines and primary tumor necrosis factor α observed in chronic inflammation lead to protein degradation through proteasome activation and reduced skeletal muscle protein synthesis (MPS) via protein kinase B/Akt downregulation...
October 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27580129/age-dependent-changes-in-inflammation-and-extracellular-matrix-in-bovine-oviduct-epithelial-cells-during-the-post-ovulatory-phase
#15
Hazuki Tanaka, Ayaka Ohtsu, Shogo Shiratsuki, Ryoka Kawahara-Miki, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna
The mammalian oviduct is an essential site for sperm storage, the transport of gametes, fertilization, and embryo development-functions that are aided by cytokines secreted from oviduct epithelial cells (OECs). Aging leads to cellular and organ dysfunction, with infertility associated with advanced maternal age. Few studies have investigated age-dependent changes in the oviduct as a possible cause of infertility, so we compared OECs from young (30-50 months) versus aged (more than 120 months) cattle. Next-generation sequencing was first used to identify age-related differences in gene expression...
September 2016: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/27554641/chronic-pancreatitis-do-serum-biomarkers-provide-an-association-with-an-inflammageing-phenotype
#16
REVIEW
Sebastian Rasch, Irena Valantiene, Artautas Mickevicius, Sebastian Beer, Jonas Rosendahl, Richard M Charnley, Stuart M Robinson
BACKGROUND: Chronic pancreatitis is an inflammatory disorder of the pancreas that is associated with accelerated mortality for patients suffering from this disease. The association between chronic inflammation and accelerated biological ageing has been well described and is often referred to as "inflammageing". In this review we seek to determine how systemic inflammation in chronic pancreatitis may contribute to an accelerated ageing phenotype. METHODS: A systematic literature search with a predefined search protocol was performed on Medline, Embase and Cochrane libraries according to the PRISMA guidelines...
September 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27554076/serum-immune-mediators-independently-associate-with-atherosclerosis-in-the-left-but-not-right-carotid-territory-of-older-individuals
#17
Wilcelly Machado-Silva, Adriane Dallanora Henriques, Gleim Dias Souza, Lucy Gomes, Aparecido Pimentel Ferreira, Ciro José Brito, Cláudio Córdova, Clayton Franco Moraes, Otávio Toledo Nóbrega
BACKGROUND AND AIM: Disturbance in the carotid arteries strongly predicts cerebrovascular events and correlates with a systemic inflammatory milieu. We investigated the relationship of a profile of 10 circulating inflammatory mediators with measures of carotid intima-media thickness (cIMT) in elderly subjects, taking traditional risk factors into account. METHODS: Clinical inspection for present and past chronic conditions and events, as well as biochemical and anthropometric measurements, was performed for patients in ambulatory setting...
August 20, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27531927/absence-of-ccr2-results-in-an-inflammaging-environment-in-young-mice-with-age-independent-impairments-in-muscle-regeneration
#18
David W Melton, Alexander C Roberts, Hanzhou Wang, Zaheer Sarwar, Michael D Wetzel, Jason T Wells, Laurel Porter, Michael T Berton, Linda M McManus, Paula K Shireman
Skeletal muscle regeneration requires coordination between dynamic cellular populations and tissue microenvironments. Macrophages, recruited via CCR2, are essential for regeneration; however, the contribution of macrophages and the role of CCR2 on nonhematopoietic cells has not been defined. In addition, aging and sex interactions in regeneration and sarcopenia are unclear. Muscle regeneration was measured in young (3-6 mo), middle (11-15 mo), old (24-32 mo) male and female CCR2(-/-) mice. Whereas age-related muscle atrophy/sarcopenia was present, regenerated myofiber cross-sectional area (CSA) in CCR2(-/-) mice was comparably impaired across all ages and sexes, with increased adipocyte area compared with wild-type (WT) mice...
November 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27510422/sleep-health-reciprocal-regulation-of-sleep-and-innate-immunity
#19
Michael R Irwin, Mark R Opp
Sleep disturbances including insomnia independently contribute to risk of inflammatory disorders and major depressive disorder. This review and overview provides an integrated understanding of the reciprocal relationships between sleep and the innate immune system and considers the role of sleep in the nocturnal regulation of the inflammatory biology dynamics; the impact of insomnia complaints, extremes of sleep duration, and experimental sleep deprivation on genomic, cellular, and systemic markers of inflammation; and the influence of sleep complaints and insomnia on inflammaging and molecular processes of cellular aging...
January 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27501491/aging-inflammation-immunity-and-periodontal-disease
#20
REVIEW
Jeffrey L Ebersole, Christina L Graves, Octavio A Gonzalez, Dolph Dawson, Lorri A Morford, Pinar Emecen Huja, James K Hartsfield, Sarandeep S Huja, Subramanya Pandruvada, Shannon M Wallet
The increased prevalence and severity of periodontal disease have long been associated with aging, such that this oral condition affects the majority of the adult population over 50 years of age. Although the immune system is a critical component for maintaining health, aging can be characterized by quantitative and qualitative modifications of the immune system. This process, termed 'immunosenescence', is a progressive modification of the immune system that leads to greater susceptibility to infections, neoplasia and autoimmunity, presumably reflecting the prolonged antigenic stimulation and/or stress responses that occur across the lifespan...
October 2016: Periodontology 2000
keyword
keyword
53517
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"