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Brandon Coder, Weikan Wang, Liefeng Wang, Zhongdao Wu, Qichuan Zhuge, Dong-Ming Su
The interaction between T cells and the central nervous system (CNS) in homeostasis and injury has been recognized being both pathogenic (CD4+ T-helper 1 - Th1, Th17 and γδT) and ameliorative (Th2 and regulatory T cells - Tregs). However, in-depth studies aimed to elucidate the precise in the aged microenvironment and the dichotomous role of Tregs have just begun and many aspects remain unclear. This is due, not only to a mutual dependency and reciprocal causation of alterations and diseases between the nervous and T cell immune systems, but also to an inconsistent aging of the two systems, which dynamically changes with CNS injury/recovery and/or aging process...
October 11, 2016: Oncotarget
Alexander Kalinkovich, Gregory Livshits
Sarcopenia, an age-associated decline in skeletal muscle mass coupled with functional deterioration, may be exacerbated by obesity leading to higher disability, frailty, morbidity and mortality rates. In the combination of sarcopenia and obesity, the state called sarcopenic obesity (SOB), some key age- and obesity-mediated factors and pathways may aggravate sarcopenia. This review will analyze the mechanisms underlying the pathogenesis of SOB. In obese adipose tissue (AT), adipocytes undergo hypertrophy, hyperplasia and activation resulted in accumulation of pro-inflammatory macrophages and other immune cells as well as dysregulated production of various adipokines that together with senescent cells and the immune cell-released cytokines and chemokines create a local pro-inflammatory status...
October 1, 2016: Ageing Research Reviews
Marcello Pinti, Victor Appay, Judith Campisi, Daniela Frasca, Tamas Fülöp, Delphine Sauce, Anis Larbi, Birgit Weinberger, Andrea Cossarizza
Major advances in preventing, delaying, or curing individual pathologies are responsible for an increasingly long life span in the developed parts of our planet, and indeed reaching eight to nine decades of life is nowadays extremely frequent. However, medical and sanitary advances have not prevented or delayed the underlying cause of the disparate pathologies occurring in the elderly: aging itself. The identification of the basis of the aging processes that drives the multiple pathologies and loss of function typical of older individuals is a major challenge in current aging research...
October 2016: European Journal of Immunology
Peter van der Kraan, Csaba Matta, Ali Mobasheri
Musculoskeletal conditions are a major burden on individuals, healthcare systems, and social care systems throughout the world, with indirect costs having a predominant economic impact. Aging is a major contributing factor to the development and progression of arthritic and musculoskeletal diseases. Indeed, aging and inflammation (often referred to as 'inflammaging') are critical risk factors for the development of osteoarthritis (OA), which is one of the most common forms of joint disease. The term 'chondrosenescence' has recently been introduced to define the age-dependent deterioration of chondrocyte function and how it undermines cartilage function in OA...
September 6, 2016: Gerontology
Dimitrios Draganidis, Leonidas G Karagounis, Ioannis Athanailidis, Athanasios Chatzinikolaou, Athanasios Z Jamurtas, Ioannis G Fatouros
Inflammaging is the chronic low-grade inflammatory state present in the elderly, characterized by increased systemic concentrations of proinflammatory cytokines. It has been shown that inflammaging increases the risk of pathologic conditions and age-related diseases, and that it also has been associated with increased skeletal muscle wasting, strength loss, and functional impairments. Experimental evidence suggests that the increased concentrations of proinflammatory cytokines and primary tumor necrosis factor α observed in chronic inflammation lead to protein degradation through proteasome activation and reduced skeletal muscle protein synthesis (MPS) via protein kinase B/Akt downregulation...
October 2016: Journal of Nutrition
Hazuki Tanaka, Ayaka Ohtsu, Shogo Shiratsuki, Ryoka Kawahara-Miki, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna
The mammalian oviduct is an essential site for sperm storage, the transport of gametes, fertilization, and embryo development-functions that are aided by cytokines secreted from oviduct epithelial cells (OECs). Aging leads to cellular and organ dysfunction, with infertility associated with advanced maternal age. Few studies have investigated age-dependent changes in the oviduct as a possible cause of infertility, so we compared OECs from young (30-50 months) versus aged (more than 120 months) cattle. Next-generation sequencing was first used to identify age-related differences in gene expression...
September 2016: Molecular Reproduction and Development
Sebastian Rasch, Irena Valantiene, Artautas Mickevicius, Sebastian Beer, Jonas Rosendahl, Richard M Charnley, Stuart M Robinson
BACKGROUND: Chronic pancreatitis is an inflammatory disorder of the pancreas that is associated with accelerated mortality for patients suffering from this disease. The association between chronic inflammation and accelerated biological ageing has been well described and is often referred to as "inflammageing". In this review we seek to determine how systemic inflammation in chronic pancreatitis may contribute to an accelerated ageing phenotype. METHODS: A systematic literature search with a predefined search protocol was performed on Medline, Embase and Cochrane libraries according to the PRISMA guidelines...
September 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Wilcelly Machado-Silva, Adriane Dallanora Henriques, Gleim Dias Souza, Lucy Gomes, Aparecido Pimentel Ferreira, Ciro José Brito, Cláudio Córdova, Clayton Franco Moraes, Otávio Toledo Nóbrega
BACKGROUND AND AIM: Disturbance in the carotid arteries strongly predicts cerebrovascular events and correlates with a systemic inflammatory milieu. We investigated the relationship of a profile of 10 circulating inflammatory mediators with measures of carotid intima-media thickness (cIMT) in elderly subjects, taking traditional risk factors into account. METHODS: Clinical inspection for present and past chronic conditions and events, as well as biochemical and anthropometric measurements, was performed for patients in ambulatory setting...
August 20, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
David W Melton, Alexander C Roberts, Hanzhou Wang, Zaheer Sarwar, Michael D Wetzel, Jason T Wells, Laurel Porter, Michael T Berton, Linda M McManus, Paula K Shireman
Skeletal muscle regeneration requires coordination between dynamic cellular populations and tissue microenvironments. Macrophages, recruited via CCR2, are essential for regeneration; however, the contribution of macrophages and the role of CCR2 on nonhematopoietic cells has not been defined. In addition, aging and sex interactions in regeneration and sarcopenia are unclear. Muscle regeneration was measured in young (3-6 mo), middle (11-15 mo), old (24-32 mo) male and female CCR2(-/-) mice. Whereas age-related muscle atrophy/sarcopenia was present, regenerated myofiber cross-sectional area (CSA) in CCR2(-/-) mice was comparably impaired across all ages and sexes, with increased adipocyte area compared with wild-type (WT) mice...
August 16, 2016: Journal of Leukocyte Biology
Michael R Irwin, Mark R Opp
Sleep disturbances including insomnia independently contribute to risk of inflammatory disorders, and major depressive disorder. This review and overview provides an integrated understanding of the reciprocal relationships between sleep and the innate immune system and considers the role of sleep in the nocturnal regulation of the inflammatory biology dynamics, the impact of insomnia complaints, extremes of sleep duration, and experimental sleep deprivation on genomic, cellular, and systemic markers of inflammation, and the influence of sleep complaints and insomnia on inflammaging and molecular processes of cellular aging...
August 11, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Jeffrey L Ebersole, Christina L Graves, Octavio A Gonzalez, Dolph Dawson, Lorri A Morford, Pinar Emecen Huja, James K Hartsfield, Sarandeep S Huja, Subramanya Pandruvada, Shannon M Wallet
The increased prevalence and severity of periodontal disease have long been associated with aging, such that this oral condition affects the majority of the adult population over 50 years of age. Although the immune system is a critical component for maintaining health, aging can be characterized by quantitative and qualitative modifications of the immune system. This process, termed 'immunosenescence', is a progressive modification of the immune system that leads to greater susceptibility to infections, neoplasia and autoimmunity, presumably reflecting the prolonged antigenic stimulation and/or stress responses that occur across the lifespan...
October 2016: Periodontology 2000
Magda Feres, Flavia Teles, Ricardo Teles, Luciene Cristina Figueiredo, Marcelo Faveri
Different mechanisms have been hypothesized to explain the increase in prevalence and severity of periodontitis in older adults, including shifts in the periodontal microbiota. However, the actual impact of aging on the composition of subgingival biofilms remains unclear. In the present article, we provide an overview of the composition of the subgingival biofilm in older adults and the potential effects of age on the oral microbiome. In particular, this review covers the following topics: (i) the oral microbiota of an aging mouth; (ii) the effects of age and time on the human oral microbiome; (iii) the potential impact of inflammaging and immunosenescence in the host-oral microbiota interactions; and (iv) the relationship of the aging oral microbiota and Alzheimer's disease...
October 2016: Periodontology 2000
Eleni Kanasi, Srinivas Ayilavarapu, Judith Jones
Epidemiologic studies show that 11% of the world's population is over 60 years of age; this is projected to increase, by 2050, to 22% of the population. Oral aging is a current focus of several organizations including the Federation Dentaire Internationale, the World Health Organization and the American and Japanese Dental Associations. In their Tokyo Declaration, the Japanese Association identified the elderly population as one of its main target groups. One of the WHO goals is for each person to retain more than 20 teeth by age 80, despite the fact that the prevalence of periodontal disease is continuously rising as the population is aging...
October 2016: Periodontology 2000
Chad A Lerner, Isaac K Sundar, Irfan Rahman
Myriad forms of endogenous and environmental stress will disrupt mitochondrial function by impacting critical processes in mitochondrial homeostasis such as mitochondrial redox system, oxidative phosphorylation, biogenesis, and mitophagy. External stressors that interfere with the steady state activity of mitochondrial functions are generally associated with an increase in reactive oxygen species, inflammatory response, and induction of cellular senescence (inflammaging) via mitochondrial damage associated molecular patterns (DAMPS) which are the key events in the pathogenesis of chronic obstructive pulmonary disease (COPD) and its exacerbations...
July 26, 2016: International Journal of Biochemistry & Cell Biology
Daniele Lana, Ludovica Iovino, Daniele Nosi, Gary L Wenk, Maria Grazia Giovannini
We examined the effects of inflammaging on memory encoding, and qualitative and quantitative modifications on proinflammatory proteins, apoptosis, neurodegeneration and morphological changes of neuron-astrocyte-microglia triads in CA3 Stratum Pyramidale (SP), Stratum Lucidum (SL) and Stratum Radiatum (SR) of young (3months) and aged rats (20months). Aged rats showed short-term memory impairments in the inhibitory avoidance task, increased expression of iNOS and activation of p38MAPK in SP, increase of apoptotic neurons in SP and of ectopic neurons in SL, and decrease of CA3 pyramidal neurons...
October 2016: Experimental Gerontology
Ainhoa Alberro, Matías Sáenz-Cuesta, Maider Muñoz-Culla, Maider Mateo-Abad, Esperanza Gonzalez, Estefania Carrasco-Garcia, Marcos J Araúzo-Bravo, Ander Matheu, Itziar Vergara, David Otaegui
In the last decades extracellular vesicles (EVs) have emerged as key players for intercellular communication. In the case of inflammation, several studies have reported that EV levels are increased in circulation during inflammatory episodes. Based on this, we investigated whether aging results in elevated EV number, as a basal proinflammatory status termed "inflammaging" has been described in aged individuals. Moreover, we also hypothesized that frailty and dependence conditions of the elderly could affect EV concentration in plasma...
2016: International Journal of Molecular Sciences
Francesco Prattichizzo, Valeria De Nigris, Lucia La Sala, Antonio Domenico Procopio, Fabiola Olivieri, Antonio Ceriello
Aging is a complex phenomenon driven by a variety of molecular alterations. A relevant feature of aging is chronic low-grade inflammation, termed "inflammaging." In type 2 diabetes mellitus (T2DM), many elements of aging appear earlier or are overrepresented, including consistent inflammaging. T2DM patients have an increased death rate, associated with an incremented inflammatory score. The source of this inflammation is debated. Recently, the senescence-associated secretory phenotype (SASP) has been proposed as the main origin of inflammaging in both aging and T2DM...
2016: Oxidative Medicine and Cellular Longevity
Monika Puzianowska-Kuźnicka, Magdalena Owczarz, Katarzyna Wieczorowska-Tobis, Pawel Nadrowski, Jerzy Chudek, Przemyslaw Slusarczyk, Anna Skalska, Marta Jonas, Edward Franek, Malgorzata Mossakowska
BACKGROUND: In the elderly, chronic low-grade inflammation (inflammaging) is a risk factor for the development of aging-related diseases and frailty. Using data from several thousand Eastern Europeans aged 65 years and older, we investigated whether the serum levels of two proinflammatory factors, interleukin-6 (IL-6) and C-reactive protein (CRP), were associated with physical and cognitive performance, and could predict mortality in successfully aging elderly. RESULTS: IL-6 and CRP levels systematically increased in an age-dependent manner in the entire study group (IL-6: n = 3496 individuals, p < 0...
2016: Immunity & Ageing: I & A
Cornel C Sieber
No abstract text is available yet for this article.
June 2016: Deutsche Medizinische Wochenschrift
William R Swindell, Xianying Xing, Yi Fritz, Doina Diaconu, Daniel I Simon, Nicole L Ward, Johann E Gudjonsson
The Mrp8 and Mrp14 proteins (calprotectin) accumulate within tissues during aging and may contribute to chronic inflammation. To address this possibility, we evaluated female calprotectin-deficient Mrp14-KO and wild-type (WT) mice at 5 and 24 months of age. However, there was no evidence that age-related inflammation is blunted in KO mice. Inflammation markers were in fact elevated in livers from old KO mice, and microarray analysis revealed more consistent elevation of genes specifically expressed by B-cells and T-cells...
May 21, 2016: Oncotarget
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