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https://www.readbyqxmd.com/read/29665347/comparison-of-revised-trauma-score-based-on-intracranial-haemorrhage-volume-among-head-injury-patients
#1
Albert Tito, Sonny G R Saragih, Diana Natalia
Head injury is one of the leading causes of mortality and morbidity at all ages and may develop into intracranial haemorrhage and increasing intracranial pressure. Pre-assessment must be conducted to head injury patients to decide the treatment plan. The aim of this study was to compare Revised Trauma Score (RTS) based on intracranial haemorrhage volume among head injury patients. This study was an analytic study with cross-sectional design where 31 patients were studied. The admission RTS and patients' status data were obtained from medical records at Dr...
2018: Prague Medical Report
https://www.readbyqxmd.com/read/29664991/haemostatic-therapies-for-acute-spontaneous-intracerebral-haemorrhage
#2
REVIEW
Rustam Al-Shahi Salman, Zhe Kang Law, Philip M Bath, Thorsten Steiner, Nikola Sprigg
BACKGROUND: Outcome after spontaneous (non-traumatic) intracerebral haemorrhage (ICH) is influenced by haematoma volume; up to one-third of ICHs enlarge within 24 hours of onset. Early haemostatic therapy might improve outcome by limiting haematoma growth. This is an update of a Cochrane Review first published in 2006, and last updated in 2009. OBJECTIVES: To examine 1) the effectiveness and safety of individual classes of haemostatic therapies, compared against placebo or open control, in adults with acute spontaneous intracerebral haemorrhage, and 2) the effects of each class of haemostatic therapy according to the type of antithrombotic drug taken immediately before ICH onset (i...
April 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29660374/a-ternary-complex-of-a-suicide-gene-a-rage-binding-peptide-and-polyethylenimine-as-a-gene-delivery-system-with-anti-tumor-and-anti-angiogenic-dual-effects-in-glioblastoma
#3
Eunji Choi, Jungju Oh, Dahee Lee, Jaewon Lee, Xiaonan Tan, Minkyung Kim, Gyeungyun Kim, Chunxian Piao, Minhyung Lee
The receptor for advanced glycation end-products (RAGE) is involved in tumor angiogenesis. Inhibition of RAGE might be an effective anti-angiogenic therapy for cancer. In this study, a cationic RAGE-binding peptide (RBP) was produced as an antagonist of RAGE, and a ternary-complex consisting of RBP, polyethylenimine (2 kDa, PEI2k), and a suicide gene (pHSVtk) was developed as a gene delivery system with dual functions: the anti-tumor effect of pHSVtk and anti-angiogenic effect of RBP. As an antagonist of RAGE, RBP decreased the secretion of vascular-endothelial growth factor (VEGF) in activated macrophages and reduced the tube-formation of endothelial cells in vitro...
April 13, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29652232/long-term-tumor-control-following-stereotactic-radiosurgery-for-jugular-paraganglioma-using-3d-volumetric-segmentation
#4
Neil S Patel, Matthew L Carlson, Bruce E Pollock, Colin L W Driscoll, Brian A Neff, Robert L Foote, Christine M Lohse, Michael J Link
OBJECTIVE The morbidity of gross-total resection of jugular paraganglioma (JP) is often unacceptable due to the potential for irreversible lower cranial neuropathy. Stereotactic radiosurgery (SRS) has been used at the authors' institution since 1990 for the treatment of JP and other benign intracranial tumors. Conventional means of assessing tumor progression using linear measurements or elliptical approximations are imprecise due to the irregular shape and insinuating growth pattern of JP. The objective of this study was to assess long-term tumor control in these patients by using slice-by-slice 3D volumetric segmentation of serial MRI data...
April 13, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29652229/a-useful-diagnostic-method-to-reduce-the-in-hospital-time-delay-for-mechanical-thrombectomy-volume-perfusion-computed-tomography-with-added-vessel-reconstruction
#5
Ho Jun Yi, Jae Hoon Sung, Dong Hoon Lee, Seung Ho Yang, Jae Taek Hong
OBJECTIVE Volume perfusion CT (VPCT) with added CT angiography (CTA)-like reconstruction from VPCT source data (VPCTA) can reveal multiple intracranial parameters. The authors examined the usefulness of VPCTA in terms of reducing the in-hospital time delay for mechanical thrombectomy. METHODS A total of 180 patients who underwent mechanical thrombectomy at the authors' institution between January 2014 and March 2017 were divided into 2 groups: a CTA-based thrombectomy decision group (group 1: CTA) and a VPCTA-based decision group (group 2: VPCTA)...
April 13, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29650593/human-neural-stem-cell-extracellular-vesicles-improve-recovery-in-a-porcine-model-of-ischemic-stroke
#6
Robin L Webb, Erin E Kaiser, Brian J Jurgielewicz, Samantha Spellicy, Shelley L Scoville, Tyler A Thompson, Raymond L Swetenburg, David C Hess, Franklin D West, Steven L Stice
BACKGROUND AND PURPOSE: Recent work from our group suggests that human neural stem cell-derived extracellular vesicle (NSC EV) treatment improves both tissue and sensorimotor function in a preclinical thromboembolic mouse model of stroke. In this study, NSC EVs were evaluated in a pig ischemic stroke model, where clinically relevant end points were used to assess recovery in a more translational large animal model. METHODS: Ischemic stroke was induced by permanent middle cerebral artery occlusion (MCAO), and either NSC EV or PBS treatment was administered intravenously at 2, 14, and 24 hours post-MCAO...
April 12, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29644809/optic-nerve-sheath-meningioma-preliminary-analysis-of-the-role-of-radiation-therapy
#7
Jun Jin, Jin Deok Joo, Jung Ho Han, Hee Kyung Yang, Jeong Min Hwang, Yi Jun Kim, In Ah Kim, Chae Yong Kim
BACKGROUND: The purpose of this study was to evaluate the treatment outcome of our optic nerve sheath meningioma (ONSM) case series in terms of preventing tumor growth and preserving vision in ONSM patients. METHODS: Between July 2003 and March 2015, 1,398 patients with intracranial meningioma were diagnosed at Seoul National University Bundang Hospital. Among them, only 13 patients (0.93%) were diagnosed with ONSM and enrolled in the present study. Tumor volume changes of ONSM patients and their visual acuity were evaluated before and after treatments...
April 2, 2018: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/29627794/association-of-follow-up-infarct-volume-with-functional-outcome-in-acute-ischemic-stroke-a-pooled-analysis-of-seven-randomized-trials
#8
Anna M M Boers, Ivo G H Jansen, Ludo F M Beenen, Thomas G Devlin, Luis San Roman, Ji Hoe Heo, Marc Ribó, Scott Brown, Mohammed A Almekhlafi, David S Liebeskind, Jeanne Teitelbaum, Hester F Lingsma, Wim H van Zwam, Patricia Cuadras, Richard du Mesnil de Rochemont, Marine Beaumont, Martin M Brown, Albert J Yoo, Robert J van Oostenbrugge, Bijoy K Menon, Geoffrey A Donnan, Jean Louis Mas, Yvo B W E M Roos, Catherine Oppenheim, Aad van der Lugt, Richard J Dowling, Michael D Hill, Antoni Davalos, Thierry Moulin, Nelly Agrinier, Andrew M Demchuk, Demetrius K Lopes, Lucia Aja Rodríguez, Diederik W J Dippel, Bruce C V Campbell, Peter J Mitchell, Fahad S Al-Ajlan, Tudor G Jovin, Jeremy Madigan, Gregory W Albers, Sebastien Soize, Francis Guillemin, Vivek K Reddy, Serge Bracard, Jordi Blasco, Keith W Muir, Raul G Nogueira, Phil M White, Mayank Goyal, Stephen M Davis, Henk A Marquering, Charles B L M Majoie
BACKGROUND: Follow-up infarct volume (FIV) has been recommended as an early indicator of treatment efficacy in patients with acute ischemic stroke. Questions remain about the optimal imaging approach for FIV measurement. OBJECTIVE: To examine the association of FIV with 90-day modified Rankin Scale (mRS) score and investigate its dependency on acquisition time and modality. METHODS: Data of seven trials were pooled. FIV was assessed on follow-up (12 hours to 2 weeks) CT or MRI...
April 7, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29627171/comparison-of-nicardipine-with-clevidipine-in-the-management-of-hypertension-in-acute-cerebrovascular-diseases
#9
Zachary Rosenfeldt, Katelyn Conklen, Breck Jones, Don Ferrill, Maithili Deshpande, Fazeel M Siddiqui
BACKGROUND AND PURPOSE: In acute stroke, hypertension worsens outcomes. Guidelines do not mention a preferred antihypertensive agent. This present study aimed to compare the efficacy and safety of nicardipine and clevidipine in acute stroke. METHODS: This retrospective review compared nicardipine with clevidipine for hypertension in acute stroke patients from March 17, 2015 to December 23, 2016. Ischemic and hemorrhagic stroke types were evaluated. Patients were excluded if under 18 years, had traumatic brain injury, had intracranial neoplasm, were on dialysis, had both study drugs during the stroke admission, or the study drug was infused for less than 1 hour...
April 4, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29622371/a-reanalysis-of-predictors-for-the-risk-of-hemorrhage-in-brain-arteriovenous-malformation
#10
Zheng Huang, Kang Peng, Changqing Chen, Feiyue Zeng, Junyu Wang, Fenghua Chen
BACKGROUND: Brain arteriovenous malformation (BAVM) is a congenital cerebral vascular disease that characterized with intracranial hemorrhage and epilepsy. It has some risk in current treatments including microsurgery, endovascular, and radiation therapy. Some patients with bAVMs may keep unruptured in their whole life. Whether it should be treated depends on the evaluation of the hemorrhage risk of bAVM. Although previous studies gave many significant predictors, we tried to find some new and more significant predictors in 173 patients with bAVMS by retrospective analysis...
April 2, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29618102/comparative-safety-and-efficacy-of-modified-tici-2b-and-tici-3-reperfusion-in-acute-ischemic-strokes-treated-with-mechanical-thrombectomy
#11
Nitin Goyal, Georgios Tsivgoulis, Donald Frei, Aquilla Turk, Blaise Baxter, Michael T Froehler, J Mocco, Muhammad Fawad Ishfaq, Konark Malhotra, Jason J Chang, Daniel Hoit, Lucas Elijovich, David Loy, Raymond D Turner, Justin Mascitelli, Kiersten Espaillat, Andrei V Alexandrov, Adam S Arthur
BACKGROUND: Mechanical thrombectomy (MT) is the current standard of care for acute ischemic stroke (AIS) patients with emergent large-vessel occlusions (ELVO). Successful reperfusion of ELVO is traditionally defined by modified Thrombolysis in Cerebral Infarction (mTICI) grades of 2b or 3. OBJECTIVE: To evaluate the comparative safety and efficacy of mTICI 2b and mTICI 3 reperfusion in AIS patients treated with MT. METHODS: Consecutive ELVO patients who underwent MT at 6 high-volume centers were included in this analysis...
March 30, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29611866/gamma-knife-radiosurgery-for-arteriovenous-malformations-general-principles-and-preliminary-results-in-a-swiss-cohort
#12
Matthieu Raboud, Constantin Tuleasca, Philippe Maeder, Luis Schiappacasse, Maud Marguet, Roy Thomas Daniel, Marc Levivier
INTRODUCTION: Arteriovenous malformations (AVMs) are a type of vascular malformation characterised by an abnormal connection between arteries and veins, bypassing the capillary system. This absence of capillaries generates an elevated pressure (hyperdebit), in both the AVM and the venous drainage, increasing the risk of rupture. Management modalities are: observation, microsurgical clipping, endovascular treatment and radiosurgery. The former can be used alone or in the frame of a multidisciplinary approach...
April 3, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29608701/stereotactic-radiosurgery-for-intracranial-ependymomas-an-international-multicenter-study
#13
Hideyuki Kano, Yan-Hua Su, Hsiu-Mei Wu, Gabriela Simonova, Roman Liscak, Or Cohen-Inbar, Jason P Sheehan, Antonio Meola, Mayur Sharma, Gene H Barnett, David Mathieu, Lucas T Vasas, Anthony M Kaufmann, Rachel C Jacobs, L Dade Lunsford
BACKGROUND: Stereotactic radiosurgery (SRS) is a potentially important option for intracranial ependymoma patients. OBJECTIVE: To analyze the outcomes of intracranial ependymoma patients who underwent SRS as a part of multimodality management. METHODS: Seven centers participating in the International Gamma Knife Research Foundation identified 89 intracranial ependymoma patients who underwent SRS (113 tumors). The median patient age was 16...
March 28, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29606500/preimplantation-genetic-diagnosis-counseling-in-autosomal-dominant-polycystic-kidney-disease
#14
Erin L Murphy, Madeline L Droher, Miriam S DiMaio, Neera K Dahl
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common hereditary forms of chronic kidney disease. Mutations within PKD1 or PKD2 lead to innumerable fluid-filled cysts in the kidneys and in some instances, end-stage renal disease (ESRD). Affected individuals have a 50% chance of passing the mutation to each of their offspring. Assisted reproductive technology using preimplantation genetic diagnosis (PGD) allows these individuals to reduce this risk to 1% to 2%. We assess the disease burden of 8 individuals with ADPKD who have undergone genetic testing in preparation for PGD...
March 30, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29598947/locoregional-extension-and-patterns-of-failure-for-nasopharyngeal-carcinoma-with-intracranial-extension
#15
Caineng Cao, Feng Jiang, Qifeng Jin, Ting Jin, Shuang Huang, Qiaoying Hu, Yuanyuan Chen, Yongfeng Piao, Yonghong Hua, Xinglai Feng, Xiaozhong Chen
OBJECTIVE: To evaluate the locoregional extension and patterns of failure for nasopharyngeal carcinoma (NPC) with intracranial extension to improve clinical target volume (CTV) delineation. PATIENTS AND METHODS: A total of 205 NPC patients with intracranial extension by magnetic resonance imaging (MRI) were retrospectively reviewed. RESULTS: According to the cumulative incidence rates of tumor invasion, we initially classified anatomic sites surrounding the nasopharynx into three risk grades: high risk (≥35%), medium risk (≥10-35%), and low risk (<10%)...
April 2018: Oral Oncology
https://www.readbyqxmd.com/read/29596338/non-invasive-electromagnetic-skin-patch-sensor-to-measure-intracranial-fluid-volume-shifts
#16
Jacob Griffith, Kim Cluff, Brandon Eckerman, Jessica Aldrich, Ryan Becker, Peer Moore-Jansen, Jeremy Patterson
Elevated intracranial fluid volume can drive intracranial pressure increases, which can potentially result in numerous neurological complications or death. This study's focus was to develop a passive skin patch sensor for the head that would non-invasively measure cranial fluid volume shifts. The sensor consists of a single baseline component configured into a rectangular planar spiral with a self-resonant frequency response when impinged upon by external radio frequency sweeps. Fluid volume changes (10 mL increments) were detected through cranial bone using the sensor on a dry human skull model...
March 29, 2018: Sensors
https://www.readbyqxmd.com/read/29594812/neutrophil-to-lymphocyte-ratio-is-an-independent-predictor-of-30-day-mortality-of-intracerebral-hemorrhage-patients-a-validation-cohort-study
#17
Fei Wang, Li Wang, Ting-Ting Jiang, Jian-Jun Xia, Feng Xu, Li-Juan Shen, Wen-Hui Kang, Yong Ding, Li-Xia Mei, Xue-Feng Ju, Shan-You Hu, Xiao Wu
In a previous study in patients with intracranial hemorrhage (ICH), we found an association between high neutrophil-to-lymphocyte ratio (NLR) with poor short-term mortality. In the current study, this preliminary finding was validated using an independent patient cohort. A total of 181 ICH patients (from January 2016 to December 2017) were included. Diagnosis was confirmed using computed tomography (CT) in all cases. Patient survival (up to 30 days) was compared between subjects with high NLR (above the 7...
March 28, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29593880/atrophy-of-the-putamen-at-time-of-clinical-motor-onset-in-huntington-s-disease-a-6-year-follow-up-study
#18
Emma M Coppen, Jeroen van der Grond, Raymund A C Roos
Background: Striatal atrophy is detectable many years before the predicted onset of motor symptoms in premanifest Huntington's disease (HD). However, the extent of these neurodegenerative changes at the actual time of conversion from premanifest to a motor manifest disease stage is not known. With this study, we aimed to assess differences in degree and rate of atrophy between converters, i.e. premanifest individuals who develop clinically manifest HD over the course of the study, and non-converters...
2018: Journal of Clinical Movement Disorders
https://www.readbyqxmd.com/read/29590315/association-of-brain-cortical-changes-with-relapse-in-patients-with-major-depressive-disorder
#19
Dario Zaremba, Katharina Dohm, Ronny Redlich, Dominik Grotegerd, Robert Strojny, Susanne Meinert, Christian Bürger, Verena Enneking, Katharina Förster, Jonathan Repple, Nils Opel, Bernhard T Baune, Pienie Zwitserlood, Walter Heindel, Volker Arolt, Harald Kugel, Udo Dannlowski
Importance: More than half of all patients with major depressive disorder (MDD) experience a relapse within 2 years after recovery. It is unclear how relapse affects brain morphologic features during the course of MDD. Objective: To use structural magnetic resonance imaging to identify morphologic brain changes associated with relapse in MDD. Design, Setting, and Participants: In this longitudinal case-control study, patients with acute MDD at baseline and healthy controls were recruited from the University of Münster Department of Psychiatry from March 21, 2010, to November 14, 2014, and were reassessed from November 11, 2012, to October 28, 2016...
March 28, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29587156/morphometric-analysis-of-posterior-fossa-and-craniovertebral-junction-in-subtypes-of-chiari-malformation
#20
Recep Basaran, Mustafa Efendioglu, Mehmet Senol, Selcuk Ozdogan, Nejat Isik
OBJECTIVES: Chiari malformations (CMs) are a group of disorders defined by anatomic anomalies of the cerebellum, brainstem, and craniovertebral junction (CVJ). In this study, we aimed to investigate morphometry of posterior fossa and CVJ in subtypes of CM and in control group, and to bring up a matter a correlation with demographic data and subtypes of CM. PATIENTS AND METHODS: The study group included patients managed for CM between 2012 and 2016 and control group...
March 20, 2018: Clinical Neurology and Neurosurgery
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