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https://www.readbyqxmd.com/read/29339440/repurposing-tin-mesoporphyrin-as-an-immune-checkpoint-inhibitor-shows-therapeutic-efficacy-in-preclinical-models-of-cancer
#1
Tamara Muliaditan, James W Opzoomer, Jonathan Caron, Mary Okesola, Paris Kosti, Sharanpreet Lall, Mieke Van Hemelrijck, Francesco Dazzi, Andrew Tutt, Anita Grigoriadis, Cheryl Gillett, Stephen F Madden, Joy M Burchell, Shahram Kordasti, Sandra S Diebold, James Spicer, James N Arnold
PURPOSE: Unprecedented clinical outcomes have been achieved in a variety of cancers by targeting immune checkpoint molecules. This preclinical study investigates heme oxygenase-1 (HO-1), an immune suppressive enzyme that is expressed in a wide variety of cancers, as a potential immune checkpoint target in the context of a chemotherapy-elicited anti-tumor immune response. We evaluate repurposing tin mesoporphyrin (SnMP), which has demonstrated safety and efficacy targeting hepatic HO in the clinic for the treatment of hyperbilirubinaemia, as an immune checkpoint blockade therapy for the treatment of cancer...
January 16, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29339234/stoichiometric-variation-and-loading-capacity-of-a-high-loading-anammox-attached-film-expanded-bed-aaeeb-reactor
#2
Yanlong Zhang, Haiyuan Ma, Rong Chen, Qigui Niu, Yu-You Li
The nitrogen loading rate (NLR) of an anammox attached film expanded bed (AAFEB) reactor was increased from 5.0 to 60.0 gN/L/d. During the stable operational period, the TN removal efficiency maintained at 87.3 ± 2.5%, and a maximum nitrogen removal rate (NRR) of 44.9 ± 0.3 gN/L/d was achieved. Overload resulted in the sharp deterioration of reactor performance, the ratio of (Food/Microorganism)/SAA should be maintained at lower than 66 ± 7% to ensure the stable operation of the AAFEB reactor...
January 9, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29338543/lucidone-suppresses-dengue-viral-replication-through-the-induction-of-heme-oxygenase-1
#3
Wei-Chun Chen, Chin-Kai Tseng, Chun-Kuang Lin, Shen-Nien Wang, Wen-Hung Wang, Shih-Hsien Hsu, Yu-Hsuan Wu, Ling-Chien Hung, Yen-Hsu Chen, Jin-Ching Lee
Dengue virus (DENV) infection causes life-threatening diseases such as dengue hemorrhagic fever and dengue shock syndrome. Currently, there is no effective therapeutic agent or vaccine against DENV infection; hence, there is an urgent need to discover anti-DENV agents. The potential therapeutic efficacy of lucidone was first evaluated in vivo using a DENV-infected Institute of Cancer Research (ICR) suckling mouse model by monitoring body weight, clinical score, survival rate, and viral titer. We found that lucidone effectively protected mice from DENV infection by sustaining survival rate and reducing viral titers in DENV-infected ICR suckling mice...
January 17, 2018: Virulence
https://www.readbyqxmd.com/read/29337893/soybean-derived-phytoalexins-improve-cognitive-function-through-activation-of-nrf2-ho-1-signaling-pathway
#4
Ji Yeon Seo, Bo Ram Kim, Jisun Oh, Jong-Sang Kim
As soy-derived glyceollins are known to induce antioxidant enzymes in various types of cells and tissues, we hypothesized that the compounds could protect neurons from damage due to reactive oxygen species (ROS). In order to examine the neuroprotective effect of glyceollins, primary cortical neurons collected from mice and mouse hippocampal HT22 cells were challenged with glutamate. Glyceollins attenuated glutamate-induced cytotoxicity in primary cortical neuron isolated from mice carrying wild-type nuclear factor (erythroid-derived 2)-like 2 (Nrf2), but the compounds were ineffective in those isolated from Nrf2 knockout mice, suggesting the involvement of the Nrf2 signaling pathway in glyceollin-mediated neuroprotection...
January 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29336940/myeloperoxidase-its-role-for-host-defense-inflammation-and-neutrophil-function
#5
REVIEW
Yasuaki Aratani
Myeloperoxidase (MPO) is a heme-containing peroxidase expressed mainly in neutrophils and to a lesser degree in monocytes. In the presence of hydrogen peroxide and halides, MPO catalyzes the formation of reactive oxygen intermediates, including hypochlorous acid (HOCl). The MPO/HOCl system plays an important role in microbial killing by neutrophils. In addition, MPO has been demonstrated to be a local mediator of tissue damage and the resulting inflammation in various inflammatory diseases. These findings have implicated MPO as an important therapeutic target in the treatment of inflammatory conditions...
January 11, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29336118/resveratrol-potently-counteracts-quercetin-starvation-induced-autophagy-and-sensitizes-hepg2-cancer-cells-to-apoptosis
#6
Sarah Tomas-Hernández, Jordi Blanco, Cristina Rojas, Joel Roca-Martínez, María José Ojeda-Montes, Raúl Beltrán-Debón, Santiago Garcia-Vallve, Gerard Pujadas, Lluís Arola, Miquel Mulero
SCOPE: Resveratrol (RSV) has been described as a potent antioxidant, anti-steatotic, and antitumor compound, and it has also been identified as a potent autophagy inducer. On the other hand, quercetin (QCT) is a dietary flavonoid with known antitumor, anti-inflammatory and antidiabetic effects. Additionally, QCT increases autophagy. To study the hypothetical synergistic effect of both compounds, we tested the combined effect of QCT and RSV on the autophagy process in HepG2 cells METHODS AND RESULTS: Autophagy was studied by western blotting, real-time RT-PCR, and cellular staining...
January 16, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29335820/how-much-do-we-know-about-hemolytic-capability-of-pathogenic-candida-species
#7
REVIEW
Márcia C Furlaneto, Helena P Góes, Hugo F Perini, Renan C Dos Santos, Luciana Furlaneto-Maia
Hemolytic factor production by pathogenic Candida species is considered an important attribute in promoting survival within the mammal host through the ability to assimilate iron from the hemoglobin-heme group. Hemolytic capability has been evaluated for Candida species based on hemolysis zones on plate assay, analysis of hemolytic activity in liquid culture medium, and hemolysis from cell-free culture broth. The production of hemolytic factor is variable among Candida species, where C. parapsilosis is the less hemolytic species...
January 15, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29335361/correction-to-discovery-of-novel-small-molecule-inducers-of-heme-oxygenase-1-that-protect-human-ipsc-derived-cardiomyocytes-from-oxidative-stress
#8
(no author information available yet)
No abstract text is available yet for this article.
February 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29334926/-r-%C3%AE-lipoic-acid-inhibits-fructose-induced-myoglobin-fructation-and-the-formation-of-advanced-glycation-end-products-ages-in-vitro
#9
Hardik Ghelani, Valentina Razmovski-Naumovski, Rajeswara Rao Pragada, Srinivas Nammi
BACKGROUND: Fructose-mediated protein glycation (fructation) has been linked to an increase in diabetic and cardiovascular complications due to over consumption of high-fructose containing diets in recent times. The objective of the present study is to evaluate the protective effect of (R)-α-lipoic acid (ALA) against fructose-induced myoglobin fructation and the formation of advanced glycation end products (AGEs) in vitro. METHODS: The anti-glycation activity of ALA was determined using the formation of AGEs fluorescence intensity, iron released from the heme moiety of myoglobin and the level of fructosamine...
January 15, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29334586/a-non-heme-iron-photocatalyst-for-light-driven-aerobic-oxidation-of-methanol
#10
Wesley Richard Browne, Juan Chen, Apparao Draksharapu, Maja Gruden, Stepan Stepanovic
The non-heme (L)FeIII and (L)FeIII-O-FeIII(L) complexes (L = 1,1-di(pyridin-2-yl)-N,N-bis(pyridin-2-ylmethyl)ethan-1-amine) undergoes reduction under irradiation to the FeII state with concomitant oxidation of methanol to methanal, without the need for a secondary photosensitizer. Spectroscopic and Density Functional Theory (DFT) studies support a mechanism in which irradiation results in charge transfer excitation of a FeIII--O-FeIII complex to generate [(L)FeIV=O]2+ (observed transiently during irradiation in acetonitrile), and an equivalent of LFeII...
January 15, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29333384/antioxidant-and-cytoprotective-activities-of-enzymatic-extracts-from-rhizoid-of-laminaria-japonica
#11
Jae-Young Je, Soo Yeon Park, Chang-Bum Ahn
Rhizoid of Laminaria japonica was hydrolyzed with proteases and carbohydrases to obtain antioxidant materials. Oxygen radical absorbance capacity (ORAC) of the enzymatic extracts was evaluated and the Protamex extract (PE) exhibited the highest ORAC value. PE also potently scavenged 2,2-diphenyl-1-picrylhydrazyl radical, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic) acid cation radical, and hydrogen peroxide (H2O2) and had good reducing power. PE inhibited hydroxyl radical-induced DNA scission by measuring the conversion of supercoiled pBR322 plasmid DNA to the open circular form...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29333383/inhibitory-effects-of-butein-on-adipogenesis-through-upregulation-of-the-nrf2-ho-1-pathway-in-3t3-l1-adipocytes
#12
Jinwoo Yang, Jeehye Sung, Younghwa Kim, Heon Sang Jeong, Junsoo Lee
Butein is reported to have many biological effects, including anti-fibrogenic, anti-cancer, and anti-inflammatory activities. This study investigated the effects of butein on adipocyte differentiation and the Nrf2/heme oxygenase-1 (HO-1) pathway's involvement in its anti adipogenic mechanism. Butein treatment reduced protein expression of key adipogenic transcription factors such as CCAAT-enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ). At a concentration of 5, 10, and 25 μM butein, PPARγ was decreased by 78...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29332049/free-heme-and-amyloid-%C3%AE-a-fatal-liaison-in-alzheimer-s-disease
#13
Elisabeth Chiziane, Henriette Telemann, Martin Krueger, Juliane Adler, Jürgen Arnhold, A Alia, Jörg Flemmig
While the etiology of Alzheimer's disease (AD) is still unknown, an increased formation of amyloid-β (Aβ) peptide and oxidative processes are major pathological mechanism of the disease. The interaction of Aβ with free heme leads to the formation of peroxidase-active Aβ-heme complexes. However, enzyme-kinetic data and systematic mutational studies are still missing. These aspects were addressed in this study to evaluate the role of Aβ-heme complexes in AD. The enzyme-kinetic measurements showed peroxidase-specific pH- and H2O2-dependencies...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29331688/coproheme-decarboxylases-phylogenetic-prediction-versus-biochemical-experiments
#14
Vera Pfanzagl, Laurenz Holcik, Daniel Maresch, Giulia Gorgone, Hanna Michlits, Paul G Furtmüller, Stefan Hofbauer
Coproheme decarboxylases (ChdCs) are enzymes responsible for the catalysis of the terminal step in the coproporphyrin-dependent heme biosynthesis pathway. Phylogenetic analyses confirm that the gene encoding for ChdCs is widespread throughout the bacterial world. It is found in monoderm bacteria (Firmicutes, Actinobacteria), diderm bacteria (e. g. Nitrospirae) and also in Archaea. In order to test phylogenetic prediction ChdC representatives from all clades were expressed and examined for their coproheme decarboxylase activity...
January 10, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29330894/structure-function-and-evolution-of-the-hemerythrin-like-domain-superfamily
#15
Claudia Alvarez-Carreño, Vikram Alva, Arturo Becerra, Antonio Lazcano
Hemerythrin-like proteins have generally been studied for their ability to reversibly bind oxygen through their binuclear non-heme iron centers. However, in recent years, it has become increasingly evident that some members of the hemerythrin-like superfamily also participate in many other biological processes. For instance, the binuclear non-heme iron site of YtfE, a hemerythrin-like protein involved in the repair of iron centers in Escherichia coli, catalyzes the reduction of nitric oxide to nitrous oxide, and the human F-box/LRR-repeat protein 5, which contains a hemerythrin-like domain, is involved in intracellular iron homeostasis...
January 13, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29329987/quantitative-proteomics-in-friedreich-s-ataxia-b-lymphocytes-a-valuable-approach-to-decipher-the-biochemical-events-responsible-for-pathogenesis
#16
Lorène Télot, Elodie Rousseau, Emmanuel Lesuisse, Camille Garcia, Bastien Morlet, Thibaut Léger, Jean-Michel Camadro, Valérie Serre
Friedreich's ataxia (FRDA) represents the most frequent type of autosomal-recessively inherited ataxia and is caused by the deficiency of frataxin, a mitochondrial protein. It is known that frataxin-deficiency leads to alterations in cellular and mitochondrial iron metabolism and impacts in the cell physiology at several levels. Frataxin is thought to play a role in iron-sulfur cluster biogenesis and heme synthesis. Currently, cellular antioxidant defense is dysregulated when frataxin is deficient, which exacerbates oxidative damage in FRDA...
January 9, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29329609/garcinia-xanthochymus-extract-protects-pc12-cells-from-h2o2-induced-apoptosis-through-modulation-of-pi3k-akt-and-nrf2-ho-1-pathways
#17
Jing Xu, Sheng Gan, Jun Li, De-Bing Wand, Yu Chen, Xin Hu, Guang-Zhong Yang
The aim of the present study was to investigate the protective effects and underlying mechanisms of Garcinia xanthochymus, a perennial medicinal plant native to Yunnan, China, against H2O2-induced oxidative damage in rat pheochromacytoma PC12 cells. Preincubation of PC12 cells with fruit EtOAc fraction (fruit-EFr., 12.5-50 µmol·L-1) of G. xanthochymus for 24 h prior to H2O2 exposure markedly improved cell viability and increased the activities of antioxidant enzymes (superoxide dismutase, catalase, and heme oxygenase-1 [HO-1]), prevented lactate dehydrogenase release and lipid peroxidation malondialdehyde production, attenuated the decrease of matrix metalloproteinases (MMP), and scavenged reactive oxygen species (ROS)...
November 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29328478/arctigenin-exerts-protective-effects-against-myocardial-infarction-via-regulation-of-inos-cox%C3%A2-2-erk1-2-and-ho%C3%A2-1-in-rats
#18
Yanmin Zhang, Yong Yang
The present study aimed to determine the protective effects of arctigenin against myocardial infarction (MI), and its effects on oxidative stress and inflammation in rats. Left anterior coronary arteries of Sprague‑Dawley rats were ligated, in order to generate an acute MI (AMI) model. Arctigenin was administered to AMI rats at 0, 50, 100 or 200 µmol/kg. Western blotting and ELISAs were performed to analyze protein expression and enzyme activity. Arctigenin was demonstrated to effectively inhibit the levels of alanine transaminase, creatine kinase‑MB and lactate dehydrogenase, and to reduce infarct size in AMI rats...
January 10, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29328470/cobalt-protoporphyrin-enhances-heme-oxygenase-1-expression-and-attenuates-liver-ischemia-reperfusion-injury-by-inhibiting-apoptosis
#19
Jing Li, Bin Wu, Dahong Teng, Xiaoye Sun, Junjie Li, Jiang Li, Guoliang Zhang, Jinzhen Cai
The aim of the present study was to investigate the preconditioning effect and underlying mechanisms of cobalt-protoporphyrin (CoPP) in a mouse model of liver ischemia‑reperfusion (I/R) injury. Mice were divided into five groups: Sham‑operated (control), I/R, I/R + CoPP, I/R + CoPP and zinc‑protoporphyrin (ZnPP) and I/R + ZnPP. Serum levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) were detected using commercial kits. The expression of the pro‑apoptotic protein caspase‑3 was detected by immunohistochemistry and the expression levels of the anti‑apoptotic protein B‑cell lymphoma 2 (Bcl‑2) and heme oxygenase 1 (HO‑1) were analyzed by western blotting...
January 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29328408/genistein-attenuates-di%C3%A2-2%C3%A2-ethylhexyl-phthalate-induced-testicular-injuries-via-activation-of-nrf2-ho%C3%A2-1-following-prepubertal-exposure
#20
Liandong Zhang, Hecheng Li, Ming Gao, Tongdian Zhang, Zhizhong Wu, Ziming Wang, Tie Chong
Di‑(2‑ethylhexyl) phthalate (DEHP) and genistein (GEN) are of the most common endocrine disrupting chemicals (EDCs) present in the environment or the diet. However, investigation of the effects of acute exposure to these two EDCs during prepuberty has been lacking. In this study, DEHP and GEN were administrated to prepubertal male Sprague‑Dawley rats by gavage from PND22 to PND35 with vehicle control, GEN 50 mg/kg body weight (bw)/day, DEHP50, 150 and 450 mg/kg bw/day, and combined treatment. Reproductive parameters including testis weight, anogenital distance and organ coefficient were evaluated on PND36...
January 9, 2018: International Journal of Molecular Medicine
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