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https://www.readbyqxmd.com/read/28817839/evaluating-the-effect-of-immune-cells-on-the-outcome-of-patients-with-mesothelioma
#1
Serena J Chee, Maria Lopez, Toby Mellows, Sharmali Gankande, Karwan A Moutasim, Scott Harris, James Clarke, Pandurangan Vijayanand, Gareth J Thomas, Christian H Ottensmeier
BACKGROUND: We systematically assessed the prognostic and predictive value of infiltrating adaptive and innate immune cells in a large cohort of patients with advanced mesothelioma. METHODS: A tissue microarray from 302 samples was constructed. Markers of adaptive immune response in T-cells (CD8(+), FOXP3(+), CD4(+), CD45RO(+), CD3(+)) and B-cells (CD20(+)), and of innate immune response; neutrophils (NP57(+)), natural killer cells (CD56(+)) and macrophages (CD68(+)) were evaluated...
August 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28817838/pharmacogenetic-determinants-of-outcomes-on-triplet-hepatic-artery-infusion-and-intravenous-cetuximab-for-liver-metastases-from-colorectal-cancer-european-trial-optiliv-nct00852228
#2
Francis Lévi, Abdoulaye Karaboué, Raphaël Saffroy, Christophe Desterke, Valerie Boige, Denis Smith, Mohamed Hebbar, Pasquale Innominato, Julien Taieb, Carlos Carvalho, Rosine Guimbaud, Christian Focan, Mohamed Bouchahda, René Adam, Michel Ducreux, Gérard Milano, Antoinette Lemoine
BACKGROUND: The hepatic artery infusion (HAI) of irinotecan, oxaliplatin and 5-fluorouracil with intravenous cetuximab achieved outstanding efficacy in previously treated patients with initially unresectable liver metastases from colorectal cancer. This planned study aimed at the identification of pharmacogenetic predictors of outcomes. METHODS: Circulating mononuclear cells were analysed for 207 single-nucleotide polymorphisms (SNPs) from 34 pharmacology genes...
August 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28817837/influence-of-dietary-insulin-scores-on-survival-in-colorectal-cancer-patients
#3
Chen Yuan, Ying Bao, Kaori Sato, Katharina Nimptsch, Mingyang Song, Jennie C Brand-Miller, Vicente Morales-Oyarvide, Emilie S Zoltick, NaNa Keum, Brian M Wolpin, Jeffrey A Meyerhardt, Andrew T Chan, Walter C Willett, Meir J Stampfer, Kana Wu, Edward L Giovannucci, Charles S Fuchs, Kimmie Ng
BACKGROUND: Although hyperinsulinemia is hypothesised to be involved in colorectal carcinogenesis, it remains unclear whether a diet inducing an elevated insulin response influences colorectal cancer (CRC) survival. METHODS: We examined the association of post-diagnosis dietary insulin scores with survival among 2006 patients from two large prospective cohorts who were diagnosed with CRC from 1976 to 2010. Dietary insulin load was calculated as a function of the food insulin index...
August 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28817836/sitting-physical-activity-and-serum-oestrogen-metabolism-in-postmenopausal-women-the-women-s-health-initiative-observational-study
#4
Hannah Oh, Hannah Arem, Charles E Matthews, Nicolas Wentzensen, Kerryn W Reding, Louise A Brinton, Garnet L Anderson, Sally B Coburn, Jane A Cauley, Chu Chen, Deborah Goodman, Ruth M Pfeiffer, Roni T Falk, Xia Xu, Britton Trabert
BACKGROUND: Prolonged sitting and lower levels of physical activity have been associated with increased levels of parent oestrogens (oestrone and oestradiol), the key hormones in female cancers, in postmenopausal women. However, it is unknown whether sitting and physical activity are associated with circulating oestrogen metabolite levels. METHODS: Among 1804 postmenopausal women enrolled in the Women's Health Initiative Observational Study, 15 serum oestrogens/oestrogen metabolites were quantified using liquid chromatography-tandem mass spectrometry...
August 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28817835/history-of-thyroid-disease-and-survival-of-ovarian-cancer-patients-results-from-the-ovarian-cancer-association-consortium-a-brief-report
#5
Albina N Minlikeeva, Jo L Freudenheim, Rikki A Cannioto, Kevin H Eng, J Brian Szender, Paul Mayor, John L Etter, Daniel W Cramer, Brenda Diergaarde, Jennifer A Doherty, Thilo Dörk, Robert Edwards, Anna deFazio, Grace Friel, Marc T Goodman, Peter Hillemanns, Estrid Høgdall, Allan Jensen, Susan J Jordan, Beth Y Karlan, Susanne K Kjær, Rüdiger Klapdor, Keitaro Matsuo, Mika Mizuno, Christina M Nagle, Kunle Odunsi, Lisa Paddock, Mary Anne Rossing, Joellen M Schildkraut, Barbara Schmalfeldt, Brahm H Segal, Kristen Starbuck, Kathryn L Terry, Penelope M Webb, Emese Zsiros, Roberta B Ness, Francesmary Modugno, Elisa V Bandera, Jenny Chang-Claude, Kirsten B Moysich
BACKGROUND: Findings from in vitro studies suggest that increased exposure to thyroid hormones can influence progression of ovarian tumours. However, epidemiologic evidence on this topic is limited. METHODS: We pooled data from 11 studies from the Ovarian Cancer Association Consortium. Using multivariate Cox proportional hazards models, we estimated associations between hyper- and hypothyroidism and medications prescribed for these conditions with 5-year all-cause survival among women diagnosed with invasive ovarian cancer...
August 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28817834/mdm2-promotes-epithelial-mesenchymal-transition-and-metastasis-of-ovarian-cancer-skov3-cells
#6
Ying Chen, Dan-Dan Wang, Ye-Ping Wu, Dan Su, Tian-Yi Zhou, Ren-Hua Gai, Ying-Ying Fu, Lin Zheng, Qiao-Jun He, Hong Zhu, Bo Yang
BACKGROUND: Metastasis accounts for the most lethal reason for the death of ovarian cancer patients, but remains largely untreated. Epithelial-mesenchymal transition (EMT) is critical for the conversion of early-stage ovarian tumours into metastatic malignancies. Thus the exploration of the signalling pathways promoting EMT would open potential opportunities for the treatment of metastatic ovarian cancer. Herein, the putative role of MDM2 in regulating EMT and metastasis of ovarian cancer SKOV3 cells was investigated...
August 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28817833/fmnl2-destabilises-commd10-to-activate-nf-%C3%AE%C2%BAb-pathway-in-invasion-and-metastasis-of-colorectal-cancer
#7
S S Yang, X M Li, M Yang, X L Ren, J L Hu, X H Zhu, F F Wang, Z C Zeng, J Y Li, Z Q Cheng, W T Liao, Y Q Ding, J Guan, L Liang
BACKGROUND: Diaphanous-related formins (DRFs), actin necleator, have been known to participate in the progression of cancer cells. We previously reported that FMNL2 (Formin-like2), a member of DRFs, was a positive regulator in colorectal cancer (CRC) metastasis, yet proteins and pathways required for the function of this pro-invasive DRFs remain to be identified. METHODS: The relationship between FMNL2 and COMMD10 was examined using Co-IP, GST pull-down, immunofluorescence and in vitro ubiquitination assay...
August 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28817817/assessment-of-direct-to-consumer-genetic-testing-policy-in-korea-based-on-consumer-preference
#8
Gicheol Jeong
AIMS: In June 2016, Korea permitted direct-to-consumer genetic testing (DTC-GT) on 42 genes. However, both the market and industry have not yet been fully activated. Considering the aforementioned context, this study provides important insights. METHODS: The Korean DTC-GT policy assessment is based on consumer preference analysis using a discrete choice experiment. In August 2016, a web-based survey was conducted to collect data from 1,200 respondents. RESULTS: The estimation results show that consumers prefer a DTC-GT product that is cheap, tests various items or genes, offers accurate test results, and guarantees the confidentiality of all information...
August 18, 2017: Public Health Genomics
https://www.readbyqxmd.com/read/28817779/the-price-may-not-be-right-the-value-of-comparison-shopping-for-prescription-drugs
#9
Sanjay Arora, Neeraj Sood, Sophie Terp, Geoffrey Joyce
OBJECTIVES: To measure variations in drug prices across and within zip codes that may reveal simple strategies to improve patients' access to prescribed medications. STUDY DESIGN: We compared drug prices at different types of pharmacies across and within local markets. In-store prices were compared with a Web-based service providing discount coupons for prescription medications. Prices were collected for 2 generic antibiotics because most patients have limited experience with them and are less likely to know the price ranges for them...
July 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28817710/excessive-use-of-wechat-social-interaction-and-locus-of-control-among-college-students-in-china
#10
Juan Hou, Yamikani Ndasauka, Yingying Jiang, Zi Ye, Ying Wang, Lizhuang Yang, Xiaoming Li, Yongjun Zhang, Liangjun Pang, Yan Kong, Fei Xu, Xiaochu Zhang
In China, the number of college students using mobile phone based messaging and social networking applications like WeChat is increasing rapidly. However, there has been minimal research into the addictive nature of these applications and the psychological characteristics associate with their excessive use. There is also no published scale available for assessing excessive use of WeChat and similar applications. In the current study, we collected data from 1,245 college students in China (715 females) and developed the WeChat Excessive Use Scale (WEUS)...
2017: PloS One
https://www.readbyqxmd.com/read/28817676/psychological-determinants-of-physical-activity-across-the-life-course-a-determinants-of-diet-and-physical-activity-dedipac-umbrella-systematic-literature-review
#11
Cristina Cortis, Anna Puggina, Caterina Pesce, Katina Aleksovska, Christoph Buck, Con Burns, Greet Cardon, Angela Carlin, Chantal Simon, Donatella Ciarapica, Giancarlo Condello, Tara Coppinger, Sara D'Haese, Marieke De Craemer, Andrea Di Blasio, Sylvia Hansen, Licia Iacoviello, Johann Issartel, Pascal Izzicupo, Lina Jaeschke, Martina Kanning, Aileen Kennedy, Fiona Chun Man Ling, Agnes Luzak, Giorgio Napolitano, Julie-Anne Nazare, Grainne O'Donoghue, Camille Perchoux, Tobias Pischon, Angela Polito, Alessandra Sannella, Holger Schulz, Rhoda Sohun, Astrid Steinbrecher, Wolfgang Schlicht, Walter Ricciardi, Loriana Castellani, Ciaran MacDonncha, Laura Capranica, Stefania Boccia
Low levels of physical activity (PA) are reported to contribute to the occurrence of non-communicable diseases over the life course. Although psychological factors have been identified as an important category concerning PA behavior, knowledge on psychological determinants of PA is still inconclusive. Therefore, the aim of this umbrella systematic literature review (SLR) was to summarize and synthesize the scientific evidence on psychological determinants of PA behavior across the life course. A systematic online search was conducted on MEDLINE, ISI Web of Science, Scopus, and SPORTDiscus databases...
2017: PloS One
https://www.readbyqxmd.com/read/28817639/impacts-of-forest-restoration-on-water-yield-a-systematic-review
#12
Solange Filoso, Maíra Ometto Bezerra, Katherine C B Weiss, Margaret A Palmer
BACKGROUND: Enhancing water provision services is a common target in forest restoration projects worldwide due to growing concerns over freshwater scarcity. However, whether or not forest cover expansion or restoration can improve water provision services is still unclear and highly disputed. PURPOSE: The goal of this review is to provide a balanced and impartial assessment of the impacts of forest restoration and forest cover expansion on water yields as informed by the scientific literature...
2017: PloS One
https://www.readbyqxmd.com/read/28817627/analysing-researchers-outreach-efforts-and-the-association-with-publication-metrics-a-case-study-of-kudos
#13
Mojisola Erdt, Htet Htet Aung, Ashley Sara Aw, Charlie Rapple, Yin-Leng Theng
With the growth of scholarly collaboration networks and social communication platforms, members of the scholarly community are experimenting with their approach to disseminating research outputs, in an effort to increase their audience and outreach. However, from a researcher's point of view, it is difficult to determine whether efforts to make work more visible are worthwhile (in terms of the association with publication metrics) and within that, difficult to assess which platform or network is most effective for sharing work and connecting to a wider audience...
2017: PloS One
https://www.readbyqxmd.com/read/28817626/acting-within-an-increasingly-confined-space-a-qualitative-study-of-sexual-behaviours-and-healthcare-needs-among-men-who-have-sex-with-men-in-a-provincial-tanzanian-city
#14
Markus Larsson, Jasmine Mohamed Shio, Michael W Ross, Anette Agardh
OBJECTIVE: To explore risk perceptions, sexual practices and healthcare needs among men who have sex with men in the provincial city of Tanga in northern Tanzania. Previous research suggests that HIV/STIs are increasing problems for this population. Yet, few studies have been conducted outside the urban area of Dar es Salaam, which has limited our knowledge about the HIV/STI risk factors and healthcare needs among men who have sex with men who live outside major metropolitan areas. METHOD: During three months in 2013, 10 in-depth interviews with men who have sex with men were conducted in Tanga...
2017: PloS One
https://www.readbyqxmd.com/read/28817559/acute-kidney-injury-occurs-only-rarely-in-patients-with-kawasaki-disease
#15
Toru Watanabe, Tadaaki Abe, Shinya Tsukano
Pediatric Research accepted article preview online, 17 August 2017. doi:10.1038/pr.2017.191.
August 17, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28817555/notes-from-the-field-death-of-a-farm-worker-after-exposure-to-manure-gas-in-an-open-air-environment-wisconsin-august-2016
#16
John M Shutske, Rebecca A Larson, Daniel M Schaefer, Liz Y Binversie, Scott Rifleman, Cheryl Skjolaas
On August 15, 2016, at approximately 6:30 a.m., a previously healthy male employee of a Wisconsin beef farm was found dead near the edge of an outdoor 60,400 square foot (1.4 acre) manure storage basin (Figure). The basin was approximately 15 feet (4.6 meters) deep and nearly full. The victim, aged 29 years, was discovered by another worker; the coroner was notified at 6:50 a.m., and he pronounced the victim dead at the scene. Thirteen dead cattle were discovered in an adjoining pen; three others were struggling to stand and were euthanized...
August 18, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28817550/role-of-microrna-93-i-in-pathogenesis-of-left-ventricular-remodeling-via-targeting-cyclin-d1
#17
Jingjing Zhang, Li Qin, Ling Han, Ying Zhao, Hongfeng Jing, Wei Song, Haili Shi
BACKGROUND The objective of this study was to identify the pathway responsible for ventricular remodeling. MATERIAL AND METHODS We collected remodeling myocardium tissue (n=18) and control myocardium tissue (n=22), and detected the expression of 4 miRNAs in these 2 groups using real-time PCR. We then searched the miRNA database online to find the candidate genes of miR-93. Real-time PCR and Western blot analysis were used to confirm the regulatory relationship. RESULTS We found that only miR-93 was decreased in remodeling myocardium tissue, and validated CCND1 to be the direct target gene of miR-93, with the "seed sequence" located within the 3'-UTR of the target gene via luciferase reporter assay system...
August 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28817505/the-effects-of-the-gaa15-on-lower-extremity-injury-incidence-and-neuromuscular-functional-outcomes-in-collegiate-gaelic-games
#18
Brenagh E Schlingermann, Clare A Lodge, Conor Gissane, Paula M Rankin
The purpose of this Observational Analytical Cohort Study was to assess the effectiveness of an injury prevention programme (IPP) - GAA15 (Gaelic Athletic Association 15) - on the incidence of injury in collegiate Gaelic games. 131 Gaelic games players (mean age 20.5 years ± SD 3.0) were used for analysis in this study. Participants completed preseason and postseason testing which involved performance of the Y Balance test. The GAA15 was employed for the intervention group; coaches were instructed to implement the programme before every training session and match throughout the collegiate GAA (Gaelic Athletic Association) season...
July 5, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28817479/comparison-of-instructional-methods-for-screening-brief-intervention-and-referral-to-treatment-for-substance-use-in-nursing-education
#19
Sarah Knopf-Amelung, Heather Gotham, Araba Kuofie, Pamela Young, Ronalda Manney Stinson, Jolene Lynn, Kendra Barker, Jessica Hildreth
Most nursing programs lack curriculum on substance use. This project evaluated 3 didactic instructional methods for teaching baccalaureate nursing students about screening, brief intervention, and referral to treatment for substance use. In-person, asynchronous narrated slides and interactive online instructional methods were all effective in developing students' competency; however, active learning methods (in-person and interactive online course) were more effective in changing students' attitudes about their role in screening and intervening for drug use...
August 16, 2017: Nurse Educator
https://www.readbyqxmd.com/read/28817476/gamification-of-nursing-education-with-digital-badges
#20
Meagan White, Teresa Shellenbarger
Digital badges (DBs) serve as an innovative approach to gamifying nursing education by engaging socially connected, technologically savvy nursing students in learning. Because assessment and credentialing mechanisms are housed and managed online, DBs are designed as visible indicators of accomplishment and skill. This article describes important considerations for faculty when incorporating game-based pedagogies such as DB into nursing education and identifies potential pitfalls with DB use that faculty should consider...
August 16, 2017: Nurse Educator
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