keyword
MENU ▼
Read by QxMD icon Read
search

Internet or chat or wiki or blog or "social media" or web or online or cyber

keyword
https://www.readbyqxmd.com/read/29156842/associations-between-egfr-gene-polymorphisms-and-susceptibility-to-glioma-a-systematic-review-and-meta-analysis-from-gwas-and-case-control-studies
#1
Xiao Yu, Nian Rong Sun, Hai Tao Jang, Shi Wen Guo, Min Xue Lian
The results of genome-wide association studies (GWAS) and case-control studies performed to investigate the associations between epidermal growth factor receptor (EGFR) gene polymorphisms and glioma risk are controversial. The aim of this systematic review and meta-analysis is to determine whether EGFR gene polymorphisms are associated with glioma risk by searching 'PubMed', 'EMBASE', 'Web of Science', 'Cochrane Library' and 'China WeiPu Library' to retrieve studies that investigated associations between EGFR gene polymorphisms and glioma risk...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156839/the-benefit-of-immunonutrition-in-patients-undergoing-hepatectomy-a-systematic-review-and-meta-analysis
#2
Chengshuo Zhang, Baomin Chen, Ao Jiao, Feng Li, Bowen Wang, Ning Sun, Jialin Zhang
Perioperative immunonutrition in liver resection remains doubtful. A systematic review and meta-analysis was conducted to compare postoperative outcomes between patients undergoing hepatectomy who received perioperative immunonutrition and those who did not.A PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Knowledge database search was performed to retrieve all of the randomized controlled trials (RCTs) evaluating the value of perioperative immunonutrition in patients undergoing hepatectomy until the end of September 2016...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156785/in-silico-and-in-vitro-identification-of-inhibitory-activities-of-sorafenib-on-histone-deacetylases-in-hepatocellular-carcinoma-cells
#3
Tsang-Pai Liu, Yi-Han Hong, Pei-Ming Yang
Although sorafenib has been approved for treating hepatocellular carcinoma (HCC), clinical results are not satisfactory. Polypharmacology (one drug with multiple molecular targets) is viewed as an attractive strategy for identifying novel mechanisms of a drug and then rationally designing more-effective next-generation therapeutic agents. In this study, a polypharmacological study of sorafenib was performed by mining the next-generation Connectivity Map (CMap) database, CLUE (https://clue.io/). We found that sorafenib may act as a histone deacetylase (HDAC) inhibitor based on similar gene expression profiles...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156446/who-is-watching-user-generated-alcohol-posts-on-social-media
#4
Eilin K Erevik, Ståle Pallesen, Cecilie S Andreassen, Øystein Vedaa, Torbjørn Torsheim
AIM: To examine students' exposure to user-generated alcohol content on social media, and identify characteristics (i.e. demographics, personality traits, alcohol use, alcohol-related cognitions, and social media factors) associated with monthly or more frequent exposure. METHOD: College/university students (N=11,236) in Bergen, Norway, completed a web-survey measuring exposure to alcohol on social media - both frequency and interpretations of alcohol content. The survey included questions regarding demographics, personality, alcohol-related cognitions, and general use of social media and alcohol...
November 14, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29156435/more-than-a-to-b-understanding-and-managing-visitor-spatial-behaviour-in-urban-forests-using-public-participation-gis
#5
Silviya Korpilo, Tarmo Virtanen, Tiina Saukkonen, Susanna Lehvävirta
Planning and management needs up-to-date, easily-obtainable and accurate information on the spatial and social aspects of visitor behaviour in order to balance human use and impacts, and protection of natural resources in public parks. We used a web-based public participation GIS (PPGIS) approach to gather citizen data on visitor behaviour in Helsinki's Central Park in order to aid collaborative spatial decision-making. The study combined smartphone GPS tracking, route drawing and a questionnaire to examine differences between user groups in their use of formal trails, off-trail behaviour and the motivations that affect it...
November 17, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29156419/segmentation-of-the-hippocampus-by-transferring-algorithmic-knowledge-for-large-cohort-processing
#6
Benjamin Thyreau, Kazunori Sato, Hiroshi Fukuda, Yasuyuki Taki
The hippocampus is a particularly interesting target for neuroscience research studies due to its essential role within the human brain. In large human cohort studies, bilateral hippocampal structures are frequently identified and measured to gain insight into human behaviour or genomic variability in neuropsychiatric disorders of interest. Automatic segmentation is performed using various algorithms, with FreeSurfer being a popular option. In this manuscript, we present a method to segment the bilateral hippocampus using a deep-learned appearance model...
November 10, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/29156401/nine-reasons-why-ecstasy-is-not-quite-what-it-used-to-be
#7
Jane Mounteney, Paul Griffiths, Alessandra Bo, Andrew Cunningham, Joao Matias, Alessandro Pirona
This paper explores the recent resurgence in use of ecstasy/MDMA in Europe and highlights keys areas of continuity and divergence between the ecstasy market of the 1990s and the current MDMA market. Based on a scoping study involving a targeted multi-source data collection exercise on MDMA, it highlights nine areas that have undergone some level of change, linked with both supply and demand for the drug. Factors discussed include: innovation in production techniques; changes in precursor chemical availability; the role of online markets; competition with other stimulants and new psychoactive substances; the increased availability of high-strength MDMA; and the shift from subcultural towards more mainstream use of the drug...
November 17, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29156266/seabirds-as-regional-biomonitors-of-legacy-toxicants-on-an-urbanized-coastline
#8
Corey A Clatterbuck, Rebecca L Lewison, Nathan G Dodder, Catherine Zeeman, Kenneth Schiff
Seabirds are often cited as sentinels of the marine environment, but are rarely used in traditional ocean and coastal contaminant monitoring. Four classes of persistent organic pollutants (POPs, n=68) and three trace elements (mercury, selenium, and arsenic) were measured in the eggs of California least terns (Sterna antillarum browni), caspian terns (Hydroprogne caspia), double-crested cormorants (Phalacrocorax auritus), and western gulls (Larus occidentalis) that nest in the Southern California Bight. Building on a periodic five year regional monitoring program, we measured contaminant exposure and assessed the utility of seabirds as regional contaminant biomonitors...
November 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29156258/developing-an-online-tool-for-identifying-at-risk-populations-to-wildfire-smoke-hazards
#9
Ambarish Vaidyanathan, Fuyuen Yip, Paul Garbe
Wildfire episodes pose a significant public health threat in the United States. Adverse health impacts associated with wildfires occur near the burn area as well as in places far downwind due to wildfire smoke exposures. Health effects associated with exposure to particulate matter arising from wildfires can range from mild eye and respiratory tract irritation to more serious outcomes such as asthma exacerbation, bronchitis, and decreased lung function. Real-time operational forecasts of wildfire smoke concentrations are available but they are not readily integrated with information on vulnerable populations necessary to identify at-risk communities during wildfire smoke episodes...
November 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29156246/the-activation-of-shame-following-dissociation-in-the-context-of-relationships-a-vignette-study
#10
Kate McKeogh, Martin J Dorahy, Kumar Yogeeswaran
BACKGROUND AND OBJECTIVES: Studies show experiences of negative affective states, such as shame, elevate dissociation. Using vignettes, this study aimed to investigate the reverse, whether experiences of dissociation in the context of varied interpersonal relationships elevate shame. METHODS: 269 adults completed online questionnaires (Dissociative Experiences Scale; Experiences of Shame Scale) and were randomly allocated to vignettes describing either dissociation or sadness in three different relationship contexts: (1) with an acquaintance, (2) with a close friend, or (3) when alone...
November 7, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/29156149/quantitative-evaluation-of-vertebral-microvascular-permeability-and-fat-fraction-in-alloxan-induced-diabetic-rabbits
#11
Lei Hu, Yun Fei Zha, Li Wang, Liang Li, Dong Xing, Wei Gong, Jiao Wang, Yuan Lin, Fei Fei Zeng, Xue Song Lu
Purpose To determine longitudinal relationships between lumbar vertebral bone marrow permeability and marrow adipose tissue in a rabbit diabetes model by using quantitative dynamic contrast agent-enhanced (DCE) magnetic resonance (MR) imaging and iterative decomposition of water and fat with the echo asymmetry and least-squares estimation quantitation (IDEAL IQ) sequence. Materials and Methods Twenty rabbits were randomly assigned to the diabetic (n = 10) or control (n = 10) group. All rabbits underwent sagittal MR imaging of the lumbar region at fixed time points (0, 4, 8, 12, and 16 weeks after alloxan injection)...
November 20, 2017: Radiology
https://www.readbyqxmd.com/read/29156148/cm-101-type-i-collagen-targeted-mr-imaging-probe-for-detection-of-liver-fibrosis
#12
Christian T Farrar, Eric M Gale, Richard Kennan, Ian Ramsay, Ricard Masia, Gunisha Arora, Kailyn Looby, Lan Wei, Jayashree Kalpathy-Cramer, Michelle M Bunzel, Chunlian Zhang, Yonghua Zhu, Taro E Akiyama, Michael Klimas, Shirly Pinto, Himashinie Diyabalanage, Kenneth K Tanabe, Valerie Humblet, Bryan C Fuchs, Peter Caravan
Purpose To evaluate the biodistribution, metabolism, and pharmacokinetics of a new type I collagen-targeted magnetic resonance (MR) probe, CM-101, and to assess its ability to help quantify liver fibrosis in animal models. Materials and Methods Biodistribution, pharmacokinetics, and stability of CM-101 in rats were measured with mass spectrometry. Bile duct-ligated (BDL) and sham-treated rats were imaged 19 days after the procedure by using a 1.5-T clinical MR imaging unit. Mice were treated with carbon tetrachloride (CCl4) or with vehicle two times a week for 10 weeks and were imaged with a 7...
November 20, 2017: Radiology
https://www.readbyqxmd.com/read/29156147/electromagnetic-navigational-bronchoscopy-versus-ct-guided-percutaneous-sampling-of-peripheral-indeterminate-pulmonary-nodules-a-cohort-study
#13
Kavita M Bhatt, Yasmeen K Tandon, Ruffin Graham, Charles T Lau, Jason K Lempel, Joseph T Azok, Peter J Mazzone, Erika Schneider, Nancy A Obuchowski, Michael A Bolen
Purpose To compare the diagnostic yield and complication rates of electromagnetic navigational bronchoscopic (ENB)-guided and computed tomography (CT)-guided percutaneous tissue sampling of lung nodules. Materials and Methods Retrospectively identified were 149 patients sampled percutaneously with CT guidance and 146 patients who underwent ENB with transbronchial biopsy of a lung lesion between 2013 and 2015. Clinical data, incidence of complications, and nodule pathologic analyses were assessed through electronic medical record review...
November 20, 2017: Radiology
https://www.readbyqxmd.com/read/29156145/fractional-flow-reserve-estimated-at-coronary-ct-angiography-in-intermediate-lesions-comparison-of-diagnostic-accuracy-of-different-methods-to-determine-coronary-flow-distribution
#14
Satoru Kishi, Andreas A Giannopoulos, Anji Tang, Nahoko Kato, Yiannis S Chatzizisis, Carole Dennie, Yu Horiuchi, Kengo Tanabe, João A C Lima, Frank J Rybicki, Dimitris Mitsouras
Purpose To compare the diagnostic accuracy of different computed tomographic (CT) fractional flow reserve (FFR) algorithms for vessels with intermediate stenosis. Materials and Methods This cross-sectional HIPAA-compliant and human research committee-approved study applied a four-step CT FFR algorithm in 61 patients (mean age, 69 years ± 10; age range, 29-89 years) with a lesion of intermediate-diameter stenosis (25%-69%) at CT angiography who underwent FFR measurement within 90 days. The per-lesion diagnostic performance of CT FFR was tested for three different approaches to estimate blood flow distribution for CT FFR calculation...
November 20, 2017: Radiology
https://www.readbyqxmd.com/read/29156143/identification-of-nuclear-localization-signals-in-the-human-homeoprotein-msx1
#15
Akio Shibata, Junichiro Machida, Seishi Yamaguchi, Masashi Kimura, Tadashi Tatematsu, Hitoshi Miyachi, Atsuo Nakayama, Kazuo Shimozato, Yoshihito Tokita
MSX1 is one of the homeoproteins with the homeodomain (HD) sequence, which regulates proliferation and differentiation of mesenchymal cells. In this study, we investigated the nuclear localization signal (NLS) in the MSX1 HD by deletion and amino acid substitution analyses. The web-based tool NLStradamus predicted two putative basic motifs in the N- and C-termini of the MSX1 HD. Green fluorescent protein (GFP) chimera studies revealed that NLS1 (<sub>161</sub>RKHKTNRKPR<sub>170</sub>) and NLS2 (<sub>216</sub>NRRAKAKR<sub>223</sub>) were independently insufficient for robust nuclear localization...
November 20, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29156088/climate-mediated-changes-in-marine-ecosystem-regulation-during-el-ni%C3%A3-o
#16
Martin Lindegren, David M Checkley, J Anthony Koslow, Ralf Goericke, Mark D Ohman
The degree to which ecosystems are regulated through bottom-up, top-down or direct physical processes represents a long-standing issue in ecology, with important consequences for resource management and conservation. In marine ecosystems, the role of bottom-up and top-down forcing has been shown to vary over spatio-temporal scales, often linked to highly variable and heterogeneously distributed environmental conditions. Ecosystem dynamics in the Northeast Pacific have been suggested to be predominately bottom-up regulated...
November 20, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29156009/discovering-cancer-vulnerabilities-using-high-throughput-micro-rna-screening
#17
Iva Nikolic, Benjamin Elsworth, Eoin Dodson, Sunny Z Wu, Cathryn M Gould, Pieter Mestdagh, Glenn M Marshall, Lisa G Horvath, Kaylene J Simpson, Alexander Swarbrick
Micro-RNAs (miRNAs) are potent regulators of gene expression and cellular phenotype. Each miRNA has the potential to target hundreds of transcripts within the cell thus controlling fundamental cellular processes such as survival and proliferation. Here, we exploit this important feature of miRNA networks to discover vulnerabilities in cancer phenotype, and map miRNA-target relationships across different cancer types. More specifically, we report the results of a functional genomics screen of 1280 miRNA mimics and inhibitors in eight cancer cell lines, and its presentation in a sophisticated interactive data portal...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29156001/dgidb-3-0-a-redesign-and-expansion-of-the-drug-gene-interaction-database
#18
Kelsy C Cotto, Alex H Wagner, Yang-Yang Feng, Susanna Kiwala, Adam C Coffman, Gregory Spies, Alex Wollam, Nicholas C Spies, Obi L Griffith, Malachi Griffith
The drug-gene interaction database (DGIdb, www.dgidb.org) consolidates, organizes and presents drug-gene interactions and gene druggability information from papers, databases and web resources. DGIdb normalizes content from 30 disparate sources and allows for user-friendly advanced browsing, searching and filtering for ease of access through an intuitive web user interface, application programming interface (API) and public cloud-based server image. DGIdb v3.0 represents a major update of the database. Nine of the previously included 24 sources were updated...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29155951/public-awareness-and-healthcare-professional-advice-for-obesity-as-a-risk-factor-for-cancer-in-the-uk-a-cross-sectional-survey
#19
Lucie Hooper, Annie S Anderson, Jack Birch, Alice S Forster, Gillian Rosenberg, Linda Bauld, Jyotsna Vohra
Background: Overweight and obesity is the second biggest preventable cause of cancer after smoking, causing ~3.4 million deaths worldwide. This study provides current UK data on awareness of the link between obesity and cancer by socio-demographic factors, including BMI, and explores to what degree healthcare professionals provide weight management advice to patients. Methods: Cross-sectional survey of 3293 adults completed an online survey in February/March 2016, weighted to be representative of the UK population aged 18+...
November 16, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/29155941/new-graft-sizing-rings-for-aortic-valve-reimplantation-procedures
#20
Matija Jelenc, Blaž Jelenc, Ivan Kneževic, Tomislav Klokocovnik
OBJECTIVES: The objective was to design sizing rings that would enable proper sizing of the graft in reimplantation procedures and to perform leaflet repair before graft implantation. METHODS: The rings were designed in Autodesk Fusion 360 (San Rafael, CA, USA) and 3D printed using a commercial online 3D printing service. We designed incomplete rings with a low profile and complete rings with a high profile. The complete rings are best suited for reimplantation procedures, whereas low profile C rings are intended for isolated aortic valve repair, where the ascending aorta is not transected...
August 11, 2017: Interactive Cardiovascular and Thoracic Surgery
keyword
keyword
53508
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"