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https://www.readbyqxmd.com/read/29784777/structure-of-an-eiic-sugar-transporter-trapped-in-an-inward-facing-conformation
#1
Zhenning Ren, Jumin Lee, Mahdi Muhammad Moosa, Yin Nian, Liya Hu, Zhichun Xu, Jason G McCoy, Allan Chris M Ferreon, Wonpil Im, Ming Zhou
The phosphoenolpyruvate-dependent phosphotransferase system (PTS) transports sugar into bacteria and phosphorylates the sugar for metabolic consumption. The PTS is important for the survival of bacteria and thus a potential target for antibiotics, but its mechanism of sugar uptake and phosphorylation remains unclear. The PTS is composed of multiple proteins, and the membrane-embedded Enzyme IIC (EIIC) component transports sugars across the membrane. Crystal structures of two members of the glucose superfamily of EIICs, bcChbC and bcMalT, were solved in the inward-facing and outward-facing conformations, and the structures suggest that sugar translocation could be achieved by movement of a structured domain that contains the sugar-binding site...
May 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29782173/field-directed-self-assembly-of-mutually-polarizable-nanoparticles
#2
Zachary M Sherman, Dipanjan Ghosh, James W Swan
Directed assembly of dielectric and paramagnetic nanoparticles can be used to synthesize diverse functional materials that polarize in response to an externally applied electric or magnetic field. However, theories capable of predicting the self-assembled states are lacking. In the proposed work, we develop a complete thermodynamic description of such assemblies for spherical nanoparticles. We show how an important physical feature of these types of particles, mutual polarization, sculpts the free energy landscape and has a remarkably strong influence on the nature of the self-assembled states...
May 21, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29781422/spirocerca-vulpis-sp-nov-spiruridae-spirocercidae-description-of-a-new-nematode-species-of-the-red-fox-vulpes-vulpes-carnivora-canidae
#3
Alicia Rojas, Gloria Sanchis-Monsonís, Amer Alić, Adnan Hodžić, Domenico Otranto, Daniel Yasur-Landau, Carlos Martínez-Carrasco, Gad Baneth
Previous studies have reported nematodes of the Spirocercidae family in the stomach nodules of red foxes (Vulpes vulpes) described as Spirocerca sp. or Spirocerca lupi (Rudolphi, 1819). We characterized spirurid worms collected from red foxes and compared them to S. lupi from domestic dogs by morphometric and phylogenetic analyses. Nematodes from red foxes differed from S. lupi by the presence of six triangular teeth-like buccal capsule structures, which are absent in the latter. Additionally, in female worms from red foxes, the distance of the vulva opening to the anterior end and the ratio of the glandular-to-muscular oesophagus lengths were larger than those of S...
May 21, 2018: Parasitology
https://www.readbyqxmd.com/read/29778635/a-critical-appraisal-of-11-th-century-treatise-by-ibn-sina-avicenna-on-the-anatomy-of-the-vascular-system-comparison-with-modern-anatomic-descriptions
#4
P Mazengenya, R Bhikha
Ibn Sina (also known as Avicenna in the West) was the most famous physician and medical scientist of the medieval era. His book, the Canon of Medicine comprised a vast collection of medical information ranging from basic medical sciences to specialised medical fields. Herein, we present an analysis of the cardiovascular system, particularly giving an in-depth comparison of the structural and functional anatomy of the arteries and veins of the body as described by Avicenna in the Canon of Medicine and comparing them to modern extant anatomical literature...
May 16, 2018: Morphologie: Bulletin de L'Association des Anatomistes
https://www.readbyqxmd.com/read/29774919/modelling-the-atomic-arrangement-of-amorphous-2d-silica-a-network-analysis
#5
Projesh Kumar Roy, Markus Heyde, Andreas Heuer
The recent experimental discovery of a semi two-dimensional silica glass has offered a realistic description of the random network theory of a silica glass structure, initially discussed by Zachariasen. To study the structure formation of silica in two dimensions, we introduce a two-body force field, based on a soft core Yukawa potential. The different configurations, sampled via Molecular dynamics simulations, can be directly compared with the experimental structures, which have been provided in the literature...
May 18, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29771189/-i-m-just-trying-to-cope-for-both-of-us-challenges-and-supports-of-family-caregivers-in-participant-directed-programs
#6
Aimee Milliken, Ellen K Mahoney, Kevin J Mahoney, Kate Mignosa, Isabella Rodriguez, Catherine Cuchetti, Megumi Inoue
Recently, national attention has focused on the needs of family caregivers providing complex chronic care, noting the necessity to better understand the scope of challenges they encounter. Although a robust body of literature exists about the scope of family caregiving, little is known specifically about the experiences and perspectives of family caregivers who support participant directed (PD) participants, particularly across the caregiving trajectory. Therefore, the aim of this qualitative descriptive study was to describe what family caregivers of individuals with developmental disabilities, physical disabilities, aging, or chronic health conditions identify as the challenges they experience as complex, and their perceptions of the effectiveness and gaps in family support resources in PD...
May 17, 2018: Journal of Gerontological Social Work
https://www.readbyqxmd.com/read/29767219/alabama-children-s-body-mass-index-nutritional-attitudes-and-food-consumption-an-exploratory-analysis
#7
Vaughn Millner, Ryon C McDermott, Bernard H Eichold
OBJECTIVES: This study had three aims: assess the extent to which middle school children in southern Alabama were classified as overweight or obese; determine the magnitude of the relation between children's attitudes toward healthy eating and their actual dietary choices; and examine the role of race, sex, and ZIP codes on children's eating attitudes and behaviors. METHODS: Registered dietitians took height and weight measurements of middle school children in southern Alabama to establish body mass index (BMI)...
May 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29759663/cellular-physiology-and-clinical-manifestations-of-fascicular-arrhythmias-in-normal-hearts
#8
REVIEW
Raphael K Sung, Penelope A Boyden, Melvin Scheinman
Fascicular ventricular arrhythmias represent a spectrum of ventricular tachycardias dependent on the specialized conduction system. Although they are more common in structurally abnormal hearts, there is an increasing body of literature describing their role in normal hearts. In this review, the authors present data from both basic and clinical research that explore the current understanding of idiopathic fascicular ventricular arrhythmias. Evaluation of the cellular electrophysiology of the Purkinje cells shows clear evidence of enhanced automaticity and triggered activity as potential mechanisms of arrhythmias...
December 11, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29741781/what-hinders-healthcare-professionals-in-promoting-physical-activity-towards-cancer-patients-the-influencing-role-of-healthcare-professionals-concerns-perceived-patient-characteristics-and-perceived-structural-factors
#9
Alexander Haussmann, Martina Gabrian, Nadine Ungar, Stefan Jooß, Joachim Wiskemann, Monika Sieverding, Karen Steindorf
Despite a large body of evidence showing that physical activity (PA) is beneficial to patients with cancer, healthcare professionals (HCPs) are promoting it too scarcely. Factors that hinder HCPs from promoting PA have remained understudied so far. Using a qualitative approach, this study aimed at a comprehensive description of influencing factors for HCPs' PA promotion behaviour and at identifying the reasons and mechanisms behind them. Semi-structured interviews with 30 HCPs were undertaken with a focus on concerns, patient characteristics and structural factors...
May 9, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29736878/vancomycin-in-pediatric-patients-with-solid-or-hematological-malignant-disease-predictive-performance-of-a-population-pharmacokinetic-model-and-new-optimized-dosing-regimens
#10
Amélie Marsot, F Gallais, C Galambrun, C Coze, O Blin, N Andre, R Guilhaumou
BACKGROUND: The application of population pharmacokinetic models and Bayesian methods offers the potential to develop individualized therapeutic approaches. OBJECTIVES: The current study presents an external evaluation of a vancomycin pharmacokinetic model in a pediatric cancer population and proposes an easy-to-use chart for clinicians for a priori vancomycin schedule adaptation to achieve target concentration. METHODS: External evaluation of a population pharmacokinetic model of vancomycin administered via continuous infusion was realized in a new retrospective dataset of pediatric patients with cancer...
May 8, 2018: Paediatric Drugs
https://www.readbyqxmd.com/read/29733465/vascular-morphology-in-normal-skin-studied-with-dynamic-optical-coherence-tomography
#11
Pernille Lindsø Andersen, Jonas Olsen, Kersti Brosbøl Engelund Friis, Lotte Themstrup, Kasper Grandahl, Ole Steen Mortensen, Gregor Borut Ernst Jemec
BACKGROUND: Dynamic optical coherence tomography (D-OCT) is a non-invasive imaging technique, suitable for the study of structural and dynamic features of cutaneous microvasculature. Studies with D-OCT have primarily focused on non-melanoma skin cancer (NMSC) and a reference description of healthy skin is lacking. OBJECTIVE: To describe the prevalence of standard microvascular features in normal skin. METHOD: A total of 280 participants without skin disease were D-OCT scanned on four body locations; three sun-exposed areas and one unexposed: forehead, back of the neck, back of the hand and medial side of the upper arm...
May 7, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29719475/first-description-of-the-larva-of-dinaraea-thomson-1858-with-comments-on-chaetotaxy-pupa-and-life-history-based-on-two-saproxylic-species-from-europe-staphylinidae-aleocharinae-athetini
#12
Bernard Staniec, Ewa Pietrykowska-Tudruj, Krzysztof Pawlęga
The paper describes the morphological ultrastructure of the previously unknown early (L1) and late larval instars (L2-3) of Dinaraea , including chaetotaxy, pupal cocoon, prepupa, and pupa, based on the saproxylic species D. aequata Erichson and D. linearis Gravenhorst. Diagnostic larval characters for the genus Dinaraea are given for the first time. Morphological differences between mature larvae of these two species relate to the colouration and degree of flattening of the body, details of antennal structure, anterior margin of the labrum, mandibles, and mala...
2018: ZooKeys
https://www.readbyqxmd.com/read/29690231/species-delimitation-in-the-gehyra-nana-squamata-gekkonidae-complex-cryptic-and-divergent-morphological-evolution-in-the-australian-monsoonal-tropics-with-the-description-of-four-new-species
#13
Paul Doughty, Gayleen Bourke, Leonardo G Tedeschi, Renae C Pratt, Paul M Oliver, Russell A Palmer, Craig Moritz
Recent advances in molecular genetic techniques and increased fine scale sampling in the Australian Monsoonal Tropics (AMT) have provided new impetus to reassess species boundaries in the Gehyra nana species complex, a clade of small-bodied, saxicolous geckos which are widely distributed across northern Australia. A recent phylogenomic analysis revealed eight deeply divergent lineages that occur as a series of overlapping distributions across the AMT and which, as a whole, are paraphyletic with four previously described species...
April 4, 2018: Zootaxa
https://www.readbyqxmd.com/read/29690120/two-new-genera-and-five-new-species-of-mugadina-like-small-grass-cicadas-hemiptera-cicadidae-cicadettini-from-central-and-eastern-australia-comparative-morphology-songs-behaviour-and-distributions
#14
A Ewart
Moulds (2012) established the genus Mugadina for two small cicadas, M. marshalli (Distant) and M. emma (Goding and Froggatt), both grass inhabiting species known from Queensland and New South Wales. Both species are notable for their relatively simple 'ticking' songs. Moulds further noted that there were at least two superficially similar genera of cicadas, but each with different genitalia. This paper describes two new genera of small (9-15 mm body lengths) and distinctive grass cicadas with genitalia that are very similar to those of Mugadina, but possess clear morphological, colour and calling song differences...
April 20, 2018: Zootaxa
https://www.readbyqxmd.com/read/29687788/new-records-of-philometrids-nematoda-philometridae-from-marine-fishes-off-australia-including-description-of-four-new-species-and-erection-of-digitiphilometroides-gen-n
#15
Frantisek Moravec, Diane P Barton
The following six species of the Philometridae (Nematoda: Dracunculoidea) were recorded from marine fishes off the northern coast of Australia in 2015 and 2016: Philometra arafurensis sp. n. and Philometra papillicaudata sp. n. from the ovary and the tissue behind the gills, respectively, of the emperor red snapper Lutjanus sebae (Cuvier); Philometra mawsonae sp. n. and Dentiphilometra malabarici sp. n. from the ovary and the tissue behind the gills, respectively, of the Malabar blood snapper Lutjanus malabaricus (Bloch et Schneider); Philometra sp...
April 16, 2018: Folia Parasitologica
https://www.readbyqxmd.com/read/29679976/optoelectronics-and-defect-levels-in-hydroxyapatite-by-first-principles
#16
Leon A Avakyan, Ekaterina V Paramonova, José Coutinho, Sven Öberg, Vladimir S Bystrov, Lusegen A Bugaev
Hydroxyapatite (HAp) is an important component of mammal bones and teeth, being widely used in prosthetic implants. Despite the importance of HAp in medicine, several promising applications involving this material (e.g., in photo-catalysis) depend on how well we understand its fundamental properties. Among the ones that are either unknown or not known accurately, we have the electronic band structure and all that relates to it, including the bandgap width. We employ state-of-the-art methodologies, including density hybrid-functional theory and many-body perturbation theory within the dynamically screened single-particle Green's function approximation, to look at the optoelectronic properties of HAp...
April 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29678587/folding-and-stabilizing-membrane-proteins-in-amphipol-a8-35
#17
REVIEW
Christel Le Bon, Anaïs Marconnet, Sandrine Masscheleyn, Jean-Luc Popot, Manuela Zoonens
Membrane proteins (MPs) are important pharmacological targets because of their involvement in many essential cellular processes whose dysfunction can lead to a large variety of diseases. A detailed knowledge of the structure of MPs and the molecular mechanisms of their activity is essential to the design of new therapeutic agents. However, studying MPs in vitro is challenging, because it generally implies their overexpression under a functional form, followed by their extraction from membranes and purification...
April 17, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29672853/morphological-development-in-the-first-life-phase-of-adriatic-sturgeon-acipenser-naccarii-under-controlled-conditions
#18
R Cabrera-Castro, C Zabala, M C Soriguer, A Domezain, J A Hernando
Early development of the Adriatic sturgeon Acipenser naccarii from its free embryo after hatching (stage 36), until late embryo stage, when the transition to exogenous feeding starts (stage 45) is described. Special emphasis is given to morphological development and description of the different structures that are formed at each life stage. After hatching, free embryos still present embryonic characteristics, little pigmentation and an ovoid yolk sac. The mouth begins to open on the 2nd day post hatch (dph) and is fully open at 3 dph...
April 19, 2018: Journal of Fish Biology
https://www.readbyqxmd.com/read/29652255/gyre-and-gimble-a-maximum-likelihood-replacement-for-patterson-correlation-refinement
#19
Airlie J McCoy, Robert D Oeffner, Claudia Millán, Massimo Sammito, Isabel Usón, Randy J Read
Descriptions are given of the maximum-likelihood gyre method implemented in Phaser for optimizing the orientation and relative position of rigid-body fragments of a model after the orientation of the model has been identified, but before the model has been positioned in the unit cell, and also the related gimble method for the refinement of rigid-body fragments of the model after positioning. Gyre refinement helps to lower the root-mean-square atomic displacements between model and target molecular-replacement solutions for the test case of antibody Fab(26-10) and improves structure solution with ARCIMBOLDO_SHREDDER...
April 1, 2018: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/29622088/re-description-of-the-sperm-morphology-of-dalbulus-maidis-hemiptera-cicadellidae-deltocephalinae
#20
Marcelo Silva Barcellos, Glenda Dias, José Lino-Neto
The corn leafhopper, Dalbulus maidis, which is one of the most important vectors of maize diseases, had the morphology of its spermatozoa described more than 40 years ago. However, the description is imprecise, requiring certain rectifications. Hence, we re-describe the sperm morphology of this species using light microscopy and transmission electron microscopy. Their spermatozoa measured from 118.1 to 128.5 μm in length, this value being about three times smaller than what was previously described. The head region is formed by a small acrosome and the nucleus...
April 2018: Tissue & Cell
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