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https://www.readbyqxmd.com/read/28222118/social-structural-behavioral-and-clinical-factors-influencing-retention-in-pre-exposure-prophylaxis-prep-care-in-mississippi
#1
Trisha Arnold, Lauren Brinkley-Rubinstein, Philip A Chan, Amaya Perez-Brumer, Estefany S Bologna, Laura Beauchamps, Kendra Johnson, Leandro Mena, Amy Nunn
Pre-exposure prophylaxis (PrEP) is a biomedical intervention that can reduce rates of HIV transmission when taken once daily by HIV-negative individuals. Little is understood about PrEP uptake and retention in care among the populations most heavily impacted by the HIV epidemic, particularly among young men who have sex with men (YMSM) in the Deep South. Therefore, this study explored the structural, social, behavioral, and clinical factors that affect PrEP use and retention in care among YMSM in Jackson, Mississippi...
2017: PloS One
https://www.readbyqxmd.com/read/28221049/childhood-gender-typed-behavior-and-adolescent-sexual-orientation-a-longitudinal-population-based-study
#2
Gu Li, Karson T F Kung, Melissa Hines
Lesbian and gay individuals have been reported to show more interest in other-sex, and/or less interest in same-sex, toys, playmates, and activities in childhood than heterosexual counterparts. Yet, most of the relevant evidence comes from retrospective studies or from prospective studies of clinically referred, extremely gender nonconforming children. In addition, findings are mixed regarding the relation between childhood gender-typed behavior and the later sexual orientation spectrum from exclusively heterosexual to exclusively lesbian/gay...
February 20, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28220321/a-snapshot-of-chlamydia-trachomatis-genetic-diversity-using-multilocus-sequence-type-analysis-in-an-australian-metropolitan-setting
#3
J A Danielewski, S Phillips, F Y S Kong, K S Smith, J S Hocking, R Guy, C K Fairley, S M Garland, S N Tabrizi
High-resolution screening methodologies which enable the differentiation of Chlamydia trachomatis at the strain level, directly from clinical samples, can provide the detailed information required for epidemiological questions such as the dynamics of treatment failure. In addition, they give a detailed snapshot of circulating C. trachomatis genetic variation, data which are currently lacking for the Australian population. In the context of two Australian clinical trials, we assessed the genetic diversity of C...
February 20, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28220310/network-centrality-and-geographical-concentration-of-social-and-service-venues-that-serve-young-men-who-have-sex-with-men
#4
Kayo Fujimoto, Rolf Turner, Lisa M Kuhns, Ju Yeong Kim, Jing Zhao, John A Schneider
This study examines network centrality of inter-venue networks formed by collaboration, competition, and sponsorship relationships among venues that serve young men who have sex with men (MSM) aged 16-29 years in relation to their geographical concentrations in Chicago, Illinois, and Houston, Texas. Our data on the physical venues comprised 116 venues in Chicago and 102 venues in Houston. We examined the relationship between the network centrality of different relations and the geographical intensity among these venues, and considered neighborhood-level socioeconomic determinants of health...
February 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28219619/effect-of-availability-of-hiv-self-testing-on-hiv-testing-frequency-in-gay-and-bisexual-men-at-high-risk-of-infection-forth-a-waiting-list-randomised-controlled-trial
#5
Muhammad S Jamil, Garrett Prestage, Christopher K Fairley, Andrew E Grulich, Kirsty S Smith, Marcus Chen, Martin Holt, Anna M McNulty, Benjamin R Bavinton, Damian P Conway, Handan Wand, Phillip Keen, Jack Bradley, Johann Kolstee, Colin Batrouney, Darren Russell, Matthew Law, John M Kaldor, Rebecca J Guy
BACKGROUND: Frequent testing of individuals at high risk of HIV is central to current prevention strategies. We aimed to determine if HIV self-testing would increase frequency of testing in high-risk gay and bisexual men, with a particular focus on men who delayed testing or had never been tested before. METHODS: In this randomised trial, HIV-negative high-risk gay and bisexual men who reported condomless anal intercourse or more than five male sexual partners in the past 3 months were recruited at three clinical and two community-based sites in Australia...
February 16, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28217323/crystal-structure-of-1r-3ar-7ar-1-s-1-2r-5s-5-3-hy-droxy-pentan-3-yl-tetra-hydro-furan-2-yl-eth-yl-7a-methyl-2-3-3a-4-5-6-7-7a-octa-hydro-1h-inden-4-one
#6
Andrea Martínez, Hugo Santalla, Fátima Garrido, Aliou Hamady Barry, Mohamed Gaye, Yagamare Fall Diop
The title compound, C21H36O3, contains an oxolane ring, and six defined stereocentres and may serve as a useful synthon for the synthesis of calcitriol analogues. The configurations of the chiral C atoms of the side chain were unambiguously established in the refinement. In the crystal, C-H⋯O and extremely weak O-H⋯O hydrogen bonds arising from the sterically hindered alcohol group link the mol-ecules into a three-dimensional network.
February 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28216139/investigation-of-braf-mutation-analysis-with-different-technical-platforms-in-metastatic-melanoma
#7
Ebru Sener, Pinar Yildirim, Ayca Tan, Ozay Gokoz, Gaye Guler Tezel
In metastatic melanoma, the detection of somatic mutations in the BRAF gene is crucial regarding patient selection for targeted therapy. Several screening methods have been developed to identify BRAF gene mutations. In this study, our objective was to evaluate the detection of the BRAF V600 mutations using two molecular methods, real-time polymerase chain (real-time PCR) assay and pyrosequencing, and immunohistochemistry (IHC), and to compare the results of these different technical platforms. This study included 98 patients diagnosed with metastatic melanoma at the Hacettepe University, Department of Pathology between 2002 and 2014...
January 21, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28215536/gel-gel-phase-separation-within-milk-sphingomyelin-domains-revealed-at-the-nanoscale-using-atomic-force-microscopy
#8
Fanny Guyomarc'h, Maohui Chen, Oumaima Et-Thakafy, Shan Zou, Christelle Lopez
The milk sphingomyelin (MSM) is involved in the formation of ordered lipid domains in the biological milk fat globule membrane (MFGM), where it accounts for about 30% of the polar lipids. Moreover, MSM exhibits a large variety in saturated acyl chain lengths (from C16:0 to C24:0-SM) compared to other natural sphingomyelins, which may impact the packing of MSM molecular species in the gel phase domains and the topography of the MFGM. To investigate this, supported lipid bilayers of synthetic sphingomyelins or of MSM-containing mixtures, including a MFGM polar lipid extract, were imaged at temperatures below the Tm of MSM (i...
February 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28213723/differences-in-orgasm-frequency-among-gay-lesbian-bisexual-and-heterosexual-men-and-women-in-a-u-s-national-sample
#9
David A Frederick, H Kate St John, Justin R Garcia, Elisabeth A Lloyd
There is a notable gap between heterosexual men and women in frequency of orgasm during sex. Little is known, however, about sexual orientation differences in orgasm frequency. We examined how over 30 different traits or behaviors were associated with frequency of orgasm when sexually intimate during the past month. We analyzed a large US sample of adults (N = 52,588) who identified as heterosexual men (n = 26,032), gay men (n = 452), bisexual men (n = 550), lesbian women (n = 340), bisexual women (n = 1112), and heterosexual women (n = 24,102)...
February 17, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28212573/dynamic-variations-in-epithelial-to-mesenchymal-transition-emt-atm-and-slfn11-govern-response-to-parp-inhibitors-and-cisplatin-in-small-cell-lung-cancer
#10
C Allison Stewart, Pan Tong, Robert J Cardnell, Triparna Sen, Lerong Li, Carl M Gay, Fatemah Masrorpour, You Fan, Rasha O Bara, Ying Feng, Yuanbin Ru, Junya Fujimoto, Samrat T Kundu, Leonard E Post, Karen Yu, Yuqiao Shen, Bonnie S Glisson, Ignatio Wistuba, John V Heymach, Don L Gibbons, Jing Wang, Lauren Averett Byers
Small cell lung cancer (SCLC) is one of the most aggressive forms of cancer, with a 5-year survival <7%. A major barrier to progress is the absence of predictive biomarkers for chemotherapy and novel targeted agents such as PARP inhibitors. Using a high-throughput, integrated proteomic, transcriptomic, and genomic analysis of SCLC patient-derived xenografts (PDXs) and profiled cell lines, we identified biomarkers of drug sensitivity and determined their prevalence in patient tumors. In contrast to breast and ovarian cancer, PARP inhibitor response was not associated with mutations in homologous recombination (HR) genes (e...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212504/-kicked-out-lgbtq-youths-bathroom-experiences-and-preferences
#11
Carolyn M Porta, Amy L Gower, Christopher J Mehus, Xiaohui Yu, Elizabeth M Saewyc, Marla E Eisenberg
Attention toward who can use which gender binary, multi-stall bathroom has brought to the forefront, once again, the ways in which youth are supported or marginalized. No study has documented sexual and gender minority youths' experiences with and perspectives about bathrooms. We collected qualitative data in 2014-2015. Participants were 25 lesbian, gay, bisexual, transgender, and queer/questioning (LGBTQ) youth, aged 14-19, in the United States and Canada. Their comments describe first- and second-hand bathroom experiences, identify advocacy efforts, and highlight the roles of peers and adults in making bathrooms safe (or not)...
February 14, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28211962/smoking-prevalence-among-lesbian-bisexual-and-queer-women-in-sydney-remains-high-analysis-of-trends-and-correlates
#12
Rachel M Deacon, Julie Mooney-Somers
INTRODUCTION AND AIMS: To investigate smoking prevalence trends and correlates among lesbian, bisexual and queer-identifying (LBQ) women in Sydney, Australia. DESIGN AND METHODS: Data from 5007 respondents to a repeated cross-sectional community survey were used to examine smoking trends between 2004 and 2014. Multinomial logistic regression was used to examine smoking correlates. RESULTS: Thirty percent of respondents were current smokers, including 48% of 16 to 24-year-olds...
February 17, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28211501/high-resolution-3d-imaging-of-whole-organ-after-clearing-taking-a-new-look-at-the-zebrafish-testis
#13
Maxence Frétaud, Laurie Rivière, Élodie De Job, Stéphanie Gay, Jean-Jacques Lareyre, Jean-Stéphane Joly, Pierre Affaticati, Violette Thermes
Zebrafish testis has become a powerful model for reproductive biology of teleostean fishes and other vertebrates and encompasses multiple applications in applied and basic research. Many studies have focused on 2D images, which is time consuming and implies extrapolation of results. Three-dimensional imaging of whole organs recently became an important challenge to better understand their architecture and allow cell enumeration. Several protocols have thus been developed to enhance sample transparency, a limiting step for imaging large biological samples...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28210919/prevalence-of-past-year-sexual-assault-victimization-among-undergraduate-students-exploring-differences-by-and-intersections-of-gender-identity-sexual-identity-and-race-ethnicity
#14
Robert W S Coulter, Christina Mair, Elizabeth Miller, John R Blosnich, Derrick D Matthews, Heather L McCauley
A critical step in developing sexual assault prevention and treatment is identifying groups at high risk for sexual assault. We explored the independent and interaction effects of sexual identity, gender identity, and race/ethnicity on past-year sexual assault among college students. From 2011 to 2013, 71,421 undergraduate students from 120 US post-secondary education institutions completed cross-sectional surveys. We fit multilevel logistic regression models to examine differences in past-year sexual assault...
February 17, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28210881/comprehensive-genomic-profiling-of-malignant-phyllodes-tumors-of-the-breast
#15
Sahar Nozad, Christine E Sheehan, Laurie M Gay, Julia A Elvin, Jo-Anne Vergilio, James Suh, Shakti Ramkissoon, Alexa B Schrock, Kim M Hirshfield, Nadia Ali, Shridar Ganesan, Siraj M Ali, Vincent A Miller, Philip J Stephens, Jeffrey S Ross, Jon H Chung
PURPOSE: Malignant phyllodes tumors (MPT) are exceptionally rare, and the genomic drivers of these tumors are still being elucidated. We performed comprehensive genomic profiling (CGP) of MPT to identify genomic alterations that will inform approaches to targeted therapy for patients with MPT, including relapsed, refractory, and metastatic disease. METHODS: DNA was extracted from formalin-fixed, paraffin-embedded samples from 24 consecutive patient cases of MPT...
February 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28210453/surgical-treatment-vs-conservative-treatment-in-intravenous-bisphosphonate-related-osteonecrosis-of-the-jaws-systematic-review
#16
REVIEW
Aida Comas-Calonge, Rui Figueiredo, Cosme Gay-Escoda
AIMS: To determine the success rates of the surgical and non-surgical treatments in the management of bisphosphonate-related osteonecrosis of the jaws (BRONJ). MATERIAL AND METHODS: A systematic review of the literature was made. A PubMed Medline database search was performed in order to include clinical studies published in English,between2004 and 2014 with the following key-words: "BRONJ AND treatment" and "NOT osteoporosis". The following data was gathered: authors, title, year of publication, aim of study, level of evidence, sample size, treatment performed, treatment outcomes and follow-up...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28209443/continued-benefit-to-rectal-separation-for-prostate-radiation-therapy-final-results-of%C3%A2-a%C3%A2-phase-iii-trial
#17
Daniel A Hamstra, Neil Mariados, John Sylvester, Dhiren Shah, Lawrence Karsh, Richard Hudes, David Beyer, Steven Kurtzman, Jeffrey Bogart, R Alex Hsi, Michael Kos, Rodney Ellis, Mark Logsdon, Shawn Zimberg, Kevin Forsythe, Hong Zhang, Edward Soffen, Patrick Francke, Constantine Mantz, Peter Rossi, Theodore DeWeese, Stephanie Daignault-Newton, Benjamin W Fischer-Valuck, Anupama Chundury, Hiram Gay, Walter Bosch, Jeff Michalski
PURPOSE: SpaceOAR, a Food and Drug Administration-approved hydrogel intended to create a rectal-prostate space, was evaluated in a single-blind phase III trial of image guided intensity modulated radiation therapy. A total of 222 men were randomized 2:1 to the spacer or control group and received 79.2 Gy in 1.8-Gy fractions to the prostate with or without the seminal vesicles. The present study reports the final results with a median follow-up period of 3 years. METHODS AND MATERIALS: Cumulative (Common Terminology Criteria for Adverse Events, version 4...
December 23, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28208119/hiv-prevention-opportunities-and-challenges
#18
Jeanne M Marrazzo
Preexposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF)-based regimens has been shown to be effective in preventing acquisition of HIV infection, with protective efficacy being dependent on adherence to treatment. Data from the PROUD (Preexposure Option for Reducing HIV in the UK) and IPERGAY (Action to Prevent Risk Exposure By and For Gay Men) studies, the later of which employed event-driven PrEP, showed a high rate of protective efficacy of PrEP with TDF and emtricitabine among men who have sex with men...
December 2017: Topics in Antiviral Medicine
https://www.readbyqxmd.com/read/28207902/methamphetamine-treatment-outcomes-among-gay-men-attending-a-lgbti-specific-treatment-service-in-sydney-australia
#19
Toby Lea, Johann Kolstee, Sarah Lambert, Ross Ness, Siobhan Hannan, Martin Holt
Gay and bisexual men (GBM) report higher rates of methamphetamine use compared to heterosexual men, and thus have a heightened risk of developing problems from their use. We examined treatment outcomes among GBM clients receiving outpatient counseling at a lesbian, gay, bisexual, transgender and intersex (LGBTI)-specific, harm reduction treatment service in Sydney, Australia. GBM receiving treatment for methamphetamine use from ACON's Substance Support Service between 2012-15 (n = 101) were interviewed at treatment commencement, and after 4 sessions (n = 60; follow-up 1) and 8 sessions (n = 32; follow-up 2)...
2017: PloS One
https://www.readbyqxmd.com/read/28207363/structural-concerns-for-msm-health-in-revising-the-precautionary-principle
#20
Barry DeCoster
No abstract text is available yet for this article.
March 2017: American Journal of Bioethics: AJOB
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