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https://www.readbyqxmd.com/read/28544589/methionine-tumor-starvation-by-erythrocyte-encapsulated-methionine-gamma-lyase-activity-controlled-with-per-os-vitamin-b6
#1
Fabien Gay, Karine Aguera, Karine Sénéchal, Angie Tainturier, Willy Berlier, Delphine Maucort-Boulch, Jérôme Honnorat, Françoise Horand, Yann Godfrin, Vanessa Bourgeaux
Erymet is a new therapy resulting from the encapsulation of a methionine gamma-lyase (MGL; EC number 4.4.1.11) in red blood cells (RBC). The aim of this study was to evaluate erymet potential efficacy in methionine (Met)-dependent cancers. We produced a highly purified MGL using a cGMP process, determined the pharmacokinetics/pharmacodynamics (PK/PD) properties of erymet in mice, and assessed its efficacy on tumor growth prevention. Cytotoxicity of purified MGL was tested in six cancer cell lines. CD1 mice were injected with single erymet product supplemented or not with vitamin B6 vitamer pyridoxine (PN; a precursor of PLP cofactor)...
May 23, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28544123/assessing-the-need-for-a-pre-exposure-prophylaxis-programme-using-the-social-media-app-grindr%C3%A2
#2
B Hampel, K Kusejko, D L Braun, J Harrison-Quintana, R Kouyos, J Fehr
OBJECTIVES: HIV pre-exposure prophylaxis (PrEP) is not approved in Switzerland and therefore must be paid for by the users themselves. We conducted a survey to find out whether men who have sex with men (MSM) in Switzerland are already taking PrEP, or are considering using it, and whether it is being taken under medical supervision or not. METHODS: Grindr® is a geosocial networking app for MSM. Between 5 and 24 January 2017, users of the app who were located in Switzerland by a global positioning system (GPS) were asked to participate in a ten-question survey on PrEP use...
May 19, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28544053/sickness-sin-and-discrimination-some-contemporary-challenges-for-uk-mental-health-nursing-practice-with-lesbian-gay-and-bisexual-lgb-people-and-communities
#3
Sarah Carr, Alfonso Pezzella
Curing 'homosexuality' or same-sex attraction has been a recurrent trope in Western psychiatry and mental health services for over a century. Despite the progress made in the UK with equality legislation, improvements in general social attitudes and the slowly increasing confidence of lesbian, gay and bisexual (LGB) individuals and communities (Carr, 2005), it appears to pose challenges for practice in the UK even today. This was recently highlighted in 2014 when the Department of Health requested the publication of a consensus statement from major UK mental health professional bodies outlining concern about and opposition to 'conversion' or 'reparative' therapy being offered to LGB people by practitioners (often working within a religious frame of reference) claiming to be able to 'cure' same-sex attraction (UK Council for Psychotherapy, 2014)...
May 25, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/28541070/syndemic-conditions-and-hiv-transmission-risk-behavior-among-hiv-negative-gay-and-bisexual-men-in-a-u-s-national-sample
#4
Jeffrey T Parsons, Brett M Millar, Raymond L Moody, Tyrel J Starks, H Jonathon Rendina, Christian Grov
OBJECTIVE: The syndemics framework has been used to explain the high rates of HIV infection among gay and bisexual men. However, most studies have relied primarily on urban or otherwise limited (e.g., single location) samples. We evaluated the prevalence of syndemics-here, depression, polydrug use, childhood sexual abuse, intimate partner violence, and sexual compulsivity-among gay and bisexual men from across the United States, including nonurban areas. METHOD: Using data from a national sample of 1,033 HIV-negative gay and bisexual men, demographic differences in the prevalence of each syndemic condition and associations with HIV transmission risk behavior were examined...
May 25, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28541059/trainees-use-of-supervision-for-therapy-with-sexual-minority-clients-a-qualitative-study
#5
Harold Chui, Kevin J McGann, Kathryn S Ziemer, Mary Ann Hoffman, Jessica Stahl
In the supervision literature, research on sexual orientation considerations often focuses on sexual minority supervisees and less often on their work with sexual minority clients. Yet both heterosexual and sexual minority supervisees serve sexual minority clients and may have different supervision needs. Twelve predoctoral interns from 12 APA-accredited counseling center internships were interviewed about how they made use of supervision for their work with a sexual minority client. The sample consisted of 6 heterosexual-identified supervisees and 6 supervisees who identified as lesbian, gay, or queer (LGQ)...
May 25, 2017: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/28541058/further-examination-of-the-factor-structure-of-the-male-role-norms-inventory-short-form-mrni-sf-measurement-considerations-for-women-men-of-color-and-gay-men
#6
Ryon C McDermott, Ronald F Levant, Joseph H Hammer, Rosalie J Hall, Daniel K McKelvey, Zachary Jones
Using multigroup structural equation modeling in a large sample of online-survey respondents (N = 6,744), the present study examined the reliability and dimensionality of the Male Role Norms Inventory-Short Form (MRNI-SF), a popular measurement of traditional masculinity ideology (TMI), and also tested measurement invariance between individuals that do and do not fit the White heterosexual male TMI reference group. Results indicated that (a) it is appropriate to model the MRNI-SF using either a bifactor or unidimensional model but not a second-order model, (b) the raw MRNI-SF total score is a suitable measure of the general TMI construct, (c) the raw self-reliance through mechanical skills and negativity toward sexual minorities subscale scores may be appropriate measures of their respective specific factors (akin to subscale factors), and (d) SEM or ipsatizing procedures should be used to model the 5 other specific factors, given the insufficient model-based reliability of their raw subscale scores...
May 25, 2017: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/28540733/hiv-risk-prevalence-and-access-to-care-among-men-who-have-sex-with-men-in-lebanon
#7
Robert Heimer, Russell Barbour, Danielle Khoury, Forrest W Crawford, Fatma Mohamed Shebl, Elie Aaraj, Kaveh Khoshnood
OBJECTIVE: Little is known about HIV prevalence and risk among men who have sex with men in much of the Middle East, including Lebanon. Recent national level surveillance has suggested an increase in HIV prevalence concentrated among men in Lebanon. We undertook a biobehavioral study to provide direct evidence for the spread of HIV. DESIGN: . MSM were recruited by respondent driven sampling, interviewed, and offered HIV testing anonymously at sites located in Beirut, Lebanon from October 2014 through February 2015...
May 25, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28540562/comparison-of-home-based-oral-fluid-rapid-hiv-self-testing-versus-mail-in-blood-sample-collection-or-medical-community-hiv-testing-by-young-adult-black-hispanic-and-white-msm-results-from-a-randomized-trial
#8
Roland C Merchant, Melissa A Clark, Tao Liu, Justin Romanoff, Joshua G Rosenberger, Jose Bauermeister, Kenneth H Mayer
We aimed to determine in a randomized trial if young adult black, Hispanic, and white men-who-have-sex-with-men (YMSM) are more likely to complete home-based oral fluid rapid HIV self-testing than either mail-in blood sample collection or medical facility/community organization-based HIV testing. Stratified by race/ethnicity, participants were randomly assigned to use a free oral fluid rapid HIV self-test (n = 142), a free mail-in blood sample collection HIV test (n = 142), or be tested at a medical facility/community organization of their choice (n = 141)...
May 24, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28538922/the-national-policy-for-comprehensive-health-of-lesbians-gays-bisexuals-and-transgender-lgbt-and-access-to-the-sex-reassignment-process-in-the-brazilian-unified-health-system-sus-progress-and-challenges
#9
Gianna Schreiber Popadiuk, Daniel Canavese Oliveira, Marcos Claudio Signorelli
This study aimed to analyze how the Brazilian Ministry of Health (MS) is implementing the Sex Reassignment Process (SRP) in the Unified Health System (SUS), through research of public domain official documents, systematization of surgery's quantitative data and analysis of meeting reports of the LGBT Health Technical Committee (CTSLGBT) of the MS. We conducted exploratory research combining quantitative and qualitative methods, using as methodological basis the normative proposal of health programs and systems evaluation study...
May 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28538786/routine-hiv-testing-in-men-who-have-sex-with-men-from-risk-to-prevention
#10
Bruna Robba Lara Redoschi, Eliana Miura Zucchi, Claudia Renata Dos Santos Barros, Vera Silvia Facciolla Paiva
We conducted a critical review of the literature on recurrent use of HIV testing in men who have sex with men (MSM). We performed a narrative review of the literature in which we analyzed the various conceptions on frequent testing over time, the implications for health programs, and the main social markers that influence the incorporation of HIV testing as routine care. Although it has existed since the 1990s, recurrent testing among MSM was frequently interpreted as increased exposure to HIV due to lack of condom use, and therefore as "unnecessary" testing...
May 18, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28538691/the-potential-cost-effectiveness-of-pre-exposure-prophylaxis-combined-with-hiv-vaccines-in-the-united-states
#11
Blythe J S Adamson, Josh J Carlson, James G Kublin, Louis P Garrison
This economic evaluation aims to support policy-making on the combined use of pre-exposure prophylaxis (PrEP) with HIV vaccines in development by evaluating the potential cost-effectiveness of implementation that would support the design of clinical trials for the assessment of combined product safety and efficacy. The target study population is a cohort of men who have sex with men (MSM) in the United States. Policy strategies considered include standard HIV prevention, daily oral PrEP, HIV vaccine, and their combination...
May 24, 2017: Vaccines
https://www.readbyqxmd.com/read/28537845/high-rates-of-access-to-health-care-disclosure-of-sexuality-and-gender-identity-to-providers-among-house-and-ball-community-members-in-new-york-city
#12
Sean Cahill, Sarah Trieweiler, John Guidry, Nelisa Rash, Layla Stamper, Kerith Conron, Nicole Turcotte, Ilana Gratch, Paige Lowry
The House and Ball community is an important cultural manifestation of resiliency for Black and Latino gay and bisexual men and transgender women. Participants at the August, 2013 House of Latex Ball in New York City were surveyed about insurance coverage, health care access, experiences in health care, and housing instability. The sample (n = 367) was 58% Black/African American and 20% Hispanic/Latino, with a mean age of 31. Fifty-five percent were gay and bisexual men. While only 6% identified as transgender, nearly half were gender nonconforming...
May 24, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28537842/-invisible-during-my-own-crisis-responses-of-lgbt-people-of-color-to-the-orlando-shooting
#13
Johanna L Ramirez, Kirsten A Gonzalez, M Paz Galupo
On June 12th, 2016, the Pulse nightclub in Orlando, Florida was the target of one of the country's deadliest mass shootings. Pulse, a gay nightclub, was hosting a Latin Pride Night the evening of the tragedy, resulting in the death of 49 victims and 53 casualties, over 90% of whom were lesbian, gay, bisexual, and transgender (LGBT) Latinx people, specifically. The present research investigates the narrative responses from LGBT people of color (LGBT-POC) following the tragedy. Results included an analysis of 94 participant narrative responses...
May 24, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28537796/coping-with-stress-as-an-lgbtq-healthcare-professional
#14
Michele J Eliason, Carl Streed, Michael Henne
Lesbian, gay, bisexual, transgender, queer, and other sexual/gender minority (LGBTQ+) healthcare providers face both general work-related stresses and working in heteronormative settings with ill-informed or hostile coworkers and patients, yet there has been little study of whether the coping strategies are specific to LGBTQ+ stress. We analyzed qualitative data from 277 healthcare professionals. Sources of stress included religiously and politically conservative coworkers, coworker/patient lack of knowledge, stresses of closeted, and concerns about being out to patients...
May 24, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28534885/modeling-combination-hcv-prevention-among-hiv-infected-men-who-have-sex-with-men-and-people-who-inject-drugs
#15
Natasha K Martin, Britt Skaathun, Peter Vickerman, David Stuart
People who inject drugs (PWID) and HIV-infected men who have sex with men (MSM) are key risk groups for HCV transmission. Mathematical modeling studies can help elucidate what level and combination of prevention intervention scale-up is required to control or eliminate epidemics among these key populations. We discuss the evidence surrounding HCV prevention interventions and provide an overview of the mathematical modeling literature projecting the impact of scaled-up HCV prevention among PWID and HIV-infected MSM...
May 23, 2017: AIDS Reviews
https://www.readbyqxmd.com/read/28534684/observed-deficiencies-in-medical-student-knowledge-of-transgender-and-intersex-health
#16
Jennifer J Liang, Ivy H Gardner, Jacob A Walker, Joshua D Safer
BACKGROUND: Lesbian, gay, bisexual, transgender, and intersex (LGBTI) patients face many well-documented disparities in care which among transgender and intersex people can often be traced to providers' lack of knowledge. METHODS: We administered surveys to examine the self-assessed knowledge and attitudes of all medical students at Boston University regarding different LGBTI subpopulations. Survey questions were based on a Likert scale from 1-5; analysis was conducted with Wilcoxon rank sum test...
May 23, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28534540/-characterising-people-who-demanded-the-rapid-hiv-test-in-andalusia-between-2013-and-2014
#17
N Lorusso, F Lozano de León-Naranjo, C Zamora Fuentes
BACKGROUND: The aim of the study was to describe people who demanded the HIV screening test in Andalusia (Spain). DESIGN: Cross-sectional study carried out by social organisation collaborating with the Program for early diagnosis of HIV in Andalusia. Participants underwent an oral HIV test and answered a survey beforehand, from September 2013 to August 2014. The study included a descriptive analysis of data and a logistic regression in order to determine the risk factors associated with a reactive test result...
April 30, 2017: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/28532570/does-3-dimensional-imaging-of-the%C3%A2-third-molar-reduce-the-risk-of-experiencing-inferior-alveolar-nerve-injury-owing-to-extraction-a-meta-analysis
#18
REVIEW
Adrià Clé-Ovejero, Alba Sánchez-Torres, Octavi Camps-Font, Cosme Gay-Escoda, Rui Figueiredo, Eduard Valmaseda-Castellón
BACKGROUND: Clinicians generally use panoramic radiographic (PR) images to assess the proximity of the mandibular third molar to the inferior alveolar nerve (IAN). However, in cases in which a patient needs to undergo a third-molar extraction, many clinicians also assess computed tomographic (CT) images to prevent nerve damage. TYPES OF STUDIES REVIEWED: Two of the authors independently searched MEDLINE (through PubMed), Cochrane Library, Scopus, and Ovid. The authors included randomized or nonrandomized longitudinal studies whose investigators had compared the number of IAN injuries after third-molar extraction in patients who had undergone preoperative CT with patients who had undergone only PR...
May 19, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28532401/risk-reassurance-and-routine-a-qualitative-study-of-narrative-understandings-of-the-potential-for-hiv-self-testing-among-men-who-have-sex-with-men-in-england
#19
T Charles Witzel, Peter Weatherburn, Alison J Rodger, Adam H Bourne, Fiona M Burns
BACKGROUND: HIV testing has seen a rapid evolution over the last decade with multiple modalities now in use globally. In recent years HIV self-testing (HIVST) has been legalised in the UK paving the way for further expansion of testing. Interventions are delivered in particular social contexts which shape uptake. It is therefore important to understand how novel interventions are likely to be received by their intended users. This study aims to understand how HIVST compliments existing testing strategies considered or adopted by men who have sex with men (MSM)...
May 22, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28531260/comparison-of-kaposi-sarcoma-risk-in-hiv-positive-adults-across-five-continents-a-multiregional-multicohort-study
#20
Julia Bohlius
Background: We compared Kaposi sarcoma (KS) risk in adults who initiated antiretroviral therapy (ART) across the Asia-Pacific, South Africa, Europe, Latin, and North America. Methods: We included cohort data of HIV-positive adults who initiated ART after 1995 within the framework of two large collaborations of observational HIV cohorts. We present incidence rates and adjusted hazard ratios (aHRs). Results: We included 208,140 patients from 57 countries...
May 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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