Flores Martín-Reyes, Ailec Ho-Plagaro, Cristina Rodríguez-Díaz, Carlos Lopez-Gómez, Sara Garcia-Serrano, Dámaris Rodriguez de Los Reyes, Montserrat Gonzalo, Jose C Fernández-Garcia, Custodia Montiel-Casado, Jose L Fernández-Aguilar, José R Fernández, Eduardo García-Fuentes, Francisca Rodríguez-Pacheco
The effect of oleic acid (OA) on the regulation of the circadian rhythm present in human visceral (VAT) and subcutaneous (SAT) adipose tissue from patients with morbid obesity has not been analyzed yet. VAT and SAT explants from patients with morbid obesity were incubated with OA to analyze the circadian regulation of clock and other genes related to lipid metabolism (SREBP-1c, FAS, LPL and CPT1), and their association with baseline variables and the improvement of these patients after bariatric surgery. There were significant differences in amplitude and acrophase in VAT with respect to SAT...
November 23, 2022: Pharmacological Research: the Official Journal of the Italian Pharmacological Society