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Transverse aortic constriction

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https://www.readbyqxmd.com/read/29147650/mitochondria-associated-microrna-expression-profiling-of-heart-failure
#1
Xiaoxia Wang, Chun Song, Xiao Zhou, Xiaorui Han, Jun Li, Zengwu Wang, Haibao Shang, Yuli Liu, Huiqing Cao
Heart failure (HF) is associated with mitochondrial dysfunction and energy metabolism impairment. MicroRNAs are implicated in the development of heart failure. However, the mitochondria enriched microRNA during heart failure remains elusive. Here, we generated a pressure overload-induced early and late stage heart failure model at 4 weeks and 8 weeks following transverse aortic constriction (TAC) in mice. We found that expression of mitochondrion protein COX4 was highly enriched in isolated mitochondria from cardiac tissues while GAPDH could hardly be detected...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29145451/stromal-interaction-molecule-1-haploinsufficiency-causes-maladaptive-response-to-pressure-overload
#2
Takayoshi Ohba, Hiroyuki Watanabe, Manabu Murakami, Kenji Iino, Takeshi Adachi, Yoshihiro Baba, Tomohiro Kurosaki, Kyoichi Ono, Hiroshi Ito
Stromal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum Ca2+ sensor, has been shown to control a Ca2+-dependent signal that promotes cardiac hypertrophy. However, whether STIM1 has adaptive role that helps to protect against cardiac overload stress remains unknown. We hypothesized that STIM1 deficiency causes a maladaptive response to pressure overload stress. We investigated STIM1 heterozygous KO (STIM1+/-) mice hearts, in which STIM1 protein levels decreased to 27% of wild-type (WT) with no compensatory increase in STIM2...
2017: PloS One
https://www.readbyqxmd.com/read/29136112/local-production-of-tenascin-c-acts-as-a-trigger-for-monocyte-macrophage-recruitment-that-provokes-cardiac-dysfunction
#3
Dounia Abbadi, Fanny Laroumanie, Mathilde Bizou, Joffrey Pozzo, Danièle Daviaud, Christine Delage, Denis Calise, Fréderique Gaits-Iacovoni, Marianne Dutaur, Florence Tortosa, Edith Renaud-Gabardos, Victorine Douin-Echinard, Anne-Catherine Prats, Jerome Roncalli, Angelo Parini, Nathalie Pizzinat
Aims: Tenascin-C (TNC) is an endogenous danger signal molecule strongly associated with inflammatory diseases and with poor outcome in patients with cardiomyopathies. Its function within pathological cardiac tissue during pressure overload remains poorly understood. Methods and results: We showed that TNC accumulates after 1 week of transverse aortic constriction (TAC) in the heart of 12-week-old male mice. By cross bone marrow transplantation experiments, we determined that TNC deposition relied on cardiac cells and not on haematopoietic cells...
November 10, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29129702/fkbp8-protects-the-heart-from-hemodynamic-stress-by-preventing-the-accumulation-of-misfolded-proteins-and-endoplasmic-reticulum-associated-apoptosis-in-mice
#4
Tomofumi Misaka, Tomokazu Murakawa, Kazuhiko Nishida, Yosuke Omori, Manabu Taneike, Shigemiki Omiya, Chris Molenaar, Yoshihiro Uno, Osamu Yamaguchi, Junji Takeda, Ajay M Shah, Kinya Otsu
Protein quality control in cardiomyocytes is crucial to maintain cellular homeostasis. The accumulation of damaged organelles, such as mitochondria and misfolded proteins in the heart is associated with heart failure. During the process to identify novel mitochondria-specific autophagy (mitophagy) receptors, we found FK506-binding protein 8 (FKBP8), also known as FKBP38, shares similar structural characteristics with a yeast mitophagy receptor, autophagy-related 32 protein. However, knockdown of FKBP8 had no effect on mitophagy in HEK293 cells or H9c2 myocytes...
November 10, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29127200/steroid-receptor-coactivator-2-src-2-coordinates-cardiomyocyte-paracrine-signaling-to-promote-pressure-overload-induced-angiogenesis
#5
Ji Ho Suh, Li Lai, Deokhwa Nam, Jong Kim, Juyeon Jo, George E Taffet, Eunah Kim, Jason T Kaelber, Hyun-Kyoung Lee, Mark L Entman, John P Cooke, Erin L Reineke
Pressure overload-induced cardiac stress induces left ventricular hypertrophy driven by increased cardiomyocyte mass. The increased energetic demand and cardiomyocyte size during hypertrophy necessitate increased fuel and oxygen delivery and stimulate angiogenesis in the left ventricular wall. We have previously shown that the transcriptional regulator steroid receptor coactivator-2 (SRC-2) controls activation of several key cardiac transcription factors and that SRC-2 loss results in extensive cardiac transcriptional remodeling...
November 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29101177/a-novel-mitochondrial-dna-repair-enzyme-attenuates-maladaptive-remodeling-and-preserves-cardiac-function-in-heart-failure
#6
Jessica M Bradley, Zhen Li, Chelsea L Organ, David J Polhemus, Hiroyuki Otsuka, Shashi Bhushan, Olena M Gorodnya, Mykhaylo Ruchko, Mark N Gillespie, Glenn L Wilson, David J Lefer
BACKGROUND: Oxidative stress results in mitochondrial DNA (mtDNA) damage and contributes to myocardial cell death. mtDNA repair enzymes are crucial for mtDNA repair and cell survival. We investigated a novel, mitochondrial-targeted fusion protein (Exscien1-III) containing endonuclease III in myocardial ischemia/reperfusion (MI/Rep) injury and transverse aortic constriction (TAC) induced heart failure. METHODS AND RESULTS: Male C57/BL6J mice (10-12 wks) were subjected to 45 min...
November 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29097327/gallic-acid-attenuates-pulmonary-fibrosis-in-a-mouse-model-of-transverse-aortic-contraction-induced-heart-failure
#7
Li Jin, Zhe Hao Piao, Simei Sun, Bin Liu, Yuhee Ryu, Sin Young Choi, Gwi Ran Kim, Hyung-Seok Kim, Hae Jin Kee, Myung Ho Jeong
Gallic acid, a trihydroxybenzoic acid found in tea and other plants, attenuates cardiac hypertrophy, fibrosis, and hypertension in animal models. However, the role of gallic acid in heart failure remains unknown. In this study, we show that gallic acid administration prevents heart failure-induced pulmonary fibrosis. Heart failure induced in mice, 8weeks after transverse aortic constriction (TAC) surgery, was confirmed by echocardiography. Treatment for 2weeks with gallic acid but not furosemide prevented cardiac dysfunction in mice...
October 30, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/29081650/edaravone-inhibits-pressure-overload-induced-cardiac-fibrosis-and-dysfunction-by-reducing-expression-of-angiotensin-ii-at1-receptor
#8
Wei-Wei Zhang, Feng Bai, Jin Wang, Rong-Hua Zheng, Li-Wang Yang, Erskine A James, Zhi-Qing Zhao
Angiotensin II (Ang II) is known to be involved in the progression of ventricular dysfunction and heart failure by eliciting cardiac fibrosis. The purpose of this study was to demonstrate whether treatment with an antioxidant compound, edaravone, reduces cardiac fibrosis and improves ventricular function by inhibiting Ang II AT1 receptor. The study was conducted in a rat model of transverse aortic constriction (TAC). In control, rats were subjected to 8 weeks of TAC. In treated rats, edaravone (10 mg/kg/day) or Ang II AT1 receptor blocker, telmisartan (10 mg/kg/day) was administered by intraperitoneal injection or gastric gavage, respectively, during TAC...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29078377/growth-hormone-releasing-hormone-attenuates-cardiac-hypertrophy-and-improves-heart-function-in-pressure-overload-induced-heart-failure
#9
Iacopo Gesmundo, Michele Miragoli, Pierluigi Carullo, Letizia Trovato, Veronica Larcher, Elisa Di Pasquale, Mara Brancaccio, Marta Mazzola, Tania Villanova, Matteo Sorge, Marina Taliano, Maria Pia Gallo, Giuseppe Alloatti, Claudia Penna, Joshua M Hare, Ezio Ghigo, Andrew V Schally, Gianluigi Condorelli, Riccarda Granata
It has been shown that growth hormone-releasing hormone (GHRH) reduces cardiomyocyte (CM) apoptosis, prevents ischemia/reperfusion injury, and improves cardiac function in ischemic rat hearts. However, it is still not known whether GHRH would be beneficial for life-threatening pathological conditions, like cardiac hypertrophy and heart failure (HF). Thus, we tested the myocardial therapeutic potential of GHRH stimulation in vitro and in vivo, using GHRH or its agonistic analog MR-409. We show that in vitro, GHRH(1-44)NH2 attenuates phenylephrine-induced hypertrophy in H9c2 cardiac cells, adult rat ventricular myocytes, and human induced pluripotent stem cell-derived CMs, decreasing expression of hypertrophic genes and regulating hypertrophic pathways...
November 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29040462/both-cardiomyocyte-and-endothelial-cell-nox4-mediate-protection-against-hemodynamic-overload-induced-remodeling
#10
Min Zhang, Heloise Mongue-Din, Daniel Martin, Norman Catibog, Ioannis Smyrnias, Xiaohong Zhang, Bin Yu, Minshu Wang, Ralf P Brandes, Katrin Schröder, Ajay M Shah
Aims: NADPH oxidase-4 (Nox4) is an important reactive oxygen species (ROS) source that is upregulated in the hemodynamically overloaded heart. Our previous studies using global Nox4 knockout (Nox4KO) mice demonstrated a protective role of Nox4 during chronic abdominal aortic banding, involving a paracrine enhancement of myocardial capillary density. However, other authors who studied cardiac-specific Nox4KO mice reported detrimental effects of Nox4 in response to transverse aortic constriction (TAC)...
October 13, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29040414/luma-is-not-essential-for-murine-cardiac-development-and-function
#11
Matthew John Stroud, Xi Fang, Jianlin Zhang, Nuno Guimarães-Camboa, Jennifer Veevers, Nancy D Dalton, Yusu Gu, William H Bradford, Kirk L Peterson, Sylvia M Evans, Larry Gerace, Ju Chen
Aims: Luma is a recently discovered, evolutionarily conserved protein expressed in mammalian heart that is associated with the LInker of Nucleoskeleton and Cytoskeleton (LINC) complex. The LINC complex structurally integrates the nucleus and the cytoplasm, and plays a critical role in mechanotransduction across the nuclear envelope. Mutations in several LINC components in both humans and mice result in various cardiomyopathies, implying they play essential, non-redundant roles. A single amino acid substitution of serine 358 to leucine (S358L) in LUMA is the unequivocal cause of a distinct form of arrhythmogenic cardiomyopathy...
October 12, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29029794/rho-kinase-inhibition-reverses-impaired-ca-2-handling-and-associated-left-ventricular-dysfunction-in-pressure-overload-induced-cardiac-hypertrophy
#12
Yusuf Olgar, Murat Cenk Celen, Bilge Eren Yamasan, Nihal Ozturk, Belma Turan, Semir Ozdemir
Recent studies have implicated a relationship between RhoA/ROCK activity and defective Ca(2+) homeostasis in hypertrophic hearts. This study investigated molecular mechanism underlying ROCK inhibition-mediated cardioprotection against pressure overload-induced cardiac hypertrophy, with a focus on Ca(2+) homeostasis. Cardiac hypertrophy model was established by performing transverse aortic constriction (TAC) in 8-week-old male rats. Groups were assigned as SHAM, TAC and TAC+Fas (rats undergoing TAC and treated with fasudil)...
November 2017: Cell Calcium
https://www.readbyqxmd.com/read/28994784/technique-of-minimally-invasive-transverse-aortic-constriction-in-mice-for-induction-of-left-ventricular-hypertrophy
#13
Reza Tavakoli, Simona Nemska, Peiman Jamshidi, Max Gassmann, Nelly Frossard
Transverse aortic constriction (TAC) in mice is one of the most commonly used surgical techniques for experimental investigation of pressure overload-induced left ventricular hypertrophy (LVH) and its progression to heart failure. In the majority of the reported investigations, this procedure is performed with intubation and ventilation of the animal which renders it demanding and time-consuming and adds to the surgical burden to the animal. The aim of this protocol is to describe a simplified technique of minimally invasive TAC without intubation and ventilation of mice...
September 25, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28993090/possible-role-of-rivaroxaban-in-attenuating-pressure-overload-induced-atrial-fibrosis-and-fibrillation
#14
Hidekazu Kondo, Ichitaro Abe, Akira Fukui, Shotaro Saito, Miho Miyoshi, Kohei Aoki, Tetsuji Shinohara, Yasushi Teshima, Kunio Yufu, Naohiko Takahashi
BACKGROUND: Coagulation factor Xa (FXa) promotes thrombus formation and exacerbates inflammation via activation of protease-activated receptor (PAR)-2. We tested the hypothesis of whether administration of direct oral anticoagulant, rivaroxaban, would attenuate transverse aortic constriction (TAC)-induced atrial inflammatory fibrosis and vulnerability to atrial fibrillation (AF) in mice. METHODS: Ten-week-old male CL57/B6 mice were divided into a sham-operation (CNT) group and TAC-surgery group...
October 6, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28982031/direct-thrombin-inhibition-with-dabigatran-attenuates-pressure-overload-induced-cardiac-fibrosis-and-dysfunction-in-mice
#15
Anping Dong, Paul Mueller, Fanmuyi Yang, Liping Yang, Andrew Morris, Susan S Smyth
INTRODUCTION: The multifunctional serine protease thrombin exerts proinflammatory and profibrotic cellular effects that may contribute to cardiac remodeling. This study was designed to investigate whether direct thrombin inhibition with dabigatran attenuates myocardial injury in the setting of pressure overload-induced heart failure. MATERIAL AND METHODS: Transverse aortic constriction (TAC) surgery was performed on C57Bl/6J male mice to elicit cardiac hypertrophy...
September 21, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28979698/stachydrine-ameliorates-pressure-overload-induced-diastolic-heart-failure-by-suppressing-myocardial-fibrosis
#16
Hui-Hua Chen, Pei Zhao, Wen-Xia Zhao, Jing Tian, Wei Guo, Ming Xu, Chen Zhang, Rong Lu
Stachydrine (Sta), a major constituent of Leonurus japonicus Houtt, has been reported to possess numerous cardioprotective effects. In this study, we evaluated the effect of Sta on pressure overload-induced diastolic heart failure in rats and investigated the mechanisms underlying the effect. Wistar rats were randomized to transverse aortic constriction (TAC) or sham operation. After 3 days, the rats that underwent TAC were randomized to treatment for a total of four experimental groups (n=10 each group): sham operation, TAC only, TAC + telmisartan (Tel), and TAC + stachydrine (Sta)...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28973020/dynamic-adaptation-of-myocardial-proteome-during-heart-failure-development
#17
Julia Rüdebusch, Alexander Benkner, Axel Poesch, Marcus Dörr, Uwe Völker, Karina Grube, Elke Hammer, Stephan B Felix
Heart failure (HF) development is characterized by huge structural changes that are crucial for disease progression. Analysis of time dependent global proteomic adaptations during HF progression offers the potential to gain deeper insights in the disease development and identify new biomarker candidates. Therefore, hearts of TAC (transverse aortic constriction) and sham mice were examined by cardiac MRI on either day 4, 14, 21, 28, 42, and 56 after surgery (n = 6 per group/time point). At each time point, proteomes of the left (LV) and right ventricles (RV) of TAC and sham mice were analyzed by mass spectrometry (MS)...
2017: PloS One
https://www.readbyqxmd.com/read/28972174/sirtuin-5-is-required-for-mouse-survival-in-response-to-cardiac-pressure-overload
#18
Kathleen A Hershberger, Dennis M Abraham, Angelical S Martin, Lan Mao, Juan Liu, Hongbo Gu, Jason W Locasale, Matthew D Hirschey
In mitochondria, the sirtuin SIRT5 is an NAD(+)-dependent protein deacylase that controls several metabolic pathways. While a wide range of SIRT5 targets has been identified, the overall function of SIRT5 in organismal metabolic homeostasis remains unclear. Given that SIRT5 expression is highest in the heart and that sirtuins are commonly stress-response proteins, we used an established model of pressure overload-induced heart muscle hypertrophy caused by transverse aortic constriction (TAC) to determine SIRT5's role in cardiac stress responses...
October 2, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28957802/overexpression-of-m3-muscarinic-receptor-suppressed-adverse-electrical-remodeling-in-hypertrophic-myocardium-via-increasing-repolarizing-k-currents
#19
Xue Chen, Yan Bai, Hanqi Sun, Zhenli Su, Jing Guo, Chuan Sun, Zhimin Du
BACKGROUND/AIMS: Cardiac hypertrophy (CH) is an adaptive response to diverse cardiovascular conditions, which is accompanied by adverse electrical remodeling manifested as abnormal K+ channel activities. M3 subtype of muscarinic acetylcholine receptor (M3-mAChR) is a novel regulator of cardiac electrical activity. In this study we aim to explore if the overexpression of M3-mAChR could attenuate the adverse electrical remodeling in CH and then uncover its underlying electrophysiological mechanisms...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28957396/low-intensity-pulsed-ultrasound-enhances-angiogenesis-and-ameliorates-contractile-dysfunction-of-pressure-overloaded-heart-in-mice
#20
Tsuyoshi Ogata, Kenta Ito, Tomohiko Shindo, Kazuaki Hatanaka, Kumiko Eguchi, Ryo Kurosawa, Yuta Kagaya, Yuto Monma, Sadamitsu Ichijo, Hirofumi Taki, Hiroshi Kanai, Hiroaki Shimokawa
INTRODUCTION: Chronic left ventricular (LV) pressure overload causes relative ischemia with resultant LV dysfunction. We have recently demonstrated that low-intensity pulsed ultrasound (LIPUS) improves myocardial ischemia in a pig model of chronic myocardial ischemia through enhanced myocardial angiogenesis. In the present study, we thus examined whether LIPUS also ameliorates contractile dysfunction in LV pressure-overloaded hearts. METHODS AND RESULTS: Chronic LV pressure overload was induced with transverse aortic constriction (TAC) in mice...
2017: PloS One
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