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https://www.readbyqxmd.com/read/29768344/synchronous-adrenocortical-carcinoma-and-ovarian-malignant-mixed-germ-cell-tumor-a-case-report-and-literature-review
#1
Ying He, Lian Xu, Qingli Li, Min Feng, Wei Wang
RATIONALE: Adrenocortical carcinoma (ACC) is an endocrine malignancy with poor prognosis, which commonly arises in a sporadic manner, but may also become a part of a familial syndrome. ACC rarely arises simultaneously with other malignant tumors. PATIENT CONCERNS: We report a case of a 29-year-old woman with ACC synchronously followed by an ovarian malignant mixed germ cell tumor. We describe the clinical, histopathological, and immunohistochemical findings and review the English literatures...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29763628/whole-snake-venoms-cytotoxic-anti-metastatic-and-antiangiogenic-properties
#2
Harald Kerkkamp, Christoph Bagowski, Jeroen Kool, Babette van Soolingen, Freek Vonk, Daniëlle Vlecken
Currently, biological and organic substances are screened in order to find a new generation of therapeutics active against cancer. Previous research has identified promising candidate peptides in snake venom. In this study, venoms from different snake species (Naja annulifera, Naja kaouthia, Ophiophagus hannah and Echis carinatus) were screened for potential anti-cancer properties using pancreatic tumour cells as the assay system. The cells were incubated with venom and then subjected to the following analyses: (i) in vitro cell death (ii) in vitro migration (iii) in vivo dissemination and (iv) in vivo angiogenesis...
May 12, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29753846/role-of-hnf1%C3%AE-in-the-differential-diagnosis-from-other-germ-cell-tumors
#3
Anne-Laure Rougemont, Jean-Christophe Tille
Identification of the yolk sac tumor (YST) component in germ cell tumors (GCT) may prove challenging, and highly sensitive and specific immunohistochemical markers are still lacking. Preliminary data from the literature suggest that HNF1β may represent a sensitive marker of YST. The specificity of HNF1β has not been addressed in GCT. A cohort of 49 YST specimens from 45 patients was designed, occurring either as pure tumors, or as a component of a mixed GCT. Immunohistochemistry was conducted on whole tumor sections using HNF1β...
May 10, 2018: Human Pathology
https://www.readbyqxmd.com/read/29752158/immortalization-of-chicken-embryonic-liver-derived-cell-line-by-stable-expression-of-hmrp18s-2-for-serotype-4-fowl-adenovirus-propagation
#4
Lei Feng, Li Chen, Junwen Yun, Zhixiang Bi, Yinghua Tang, Peipei Wu, Jibo Hou
Inclusion body hepatitis and hydropericardium-hepatitis syndrome caused by serotype 4 fowl adenovirus (FAdV-4) have emerged in China since 2013. FAdV is usually propagated in primary chicken embryonic liver cells or embryo yolk sac. The aim of this work was to develop an immortalized CEL cell line by stable expression of human mitochondrial ribosomal protein 18S-2, named CEL-hMRP18S-2 cells, for the propagation of FAdV-4. The maximum cell density of CEL-hMRP18S-2 cells could reach 2.65 × 106  cells/ml in four-days culture...
May 8, 2018: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/29734649/toxicological-assessment-of-a-lignin-core-nanoparticle-doped-with-silver-as-an-alternative-to-conventional-silver-core-nanoparticles
#5
Cassandra E Nix, Bryan J Harper, Cathryn G Conner, Alexander P Richter, Orlin D Velev, Stacey L Harper
Elevated levels of silver in the environment are anticipated with an increase in silver nanoparticle (AgNP) production and use in consumer products. To potentially reduce the burden of silver ion release from conventional solid core AgNPs, a lignin-core particle doped with silver ions and surface-stabilized with a polycationic electrolyte layer was engineered. Our objective was to determine whether any of the formulation components elicit toxicological responses using embryonic zebrafish. Ionic silver and free surface stabilizer were the most toxic constituents, although when associated separately or together with the lignin core particles, the toxicity of the formulations decreased significantly...
May 4, 2018: Antibiotics
https://www.readbyqxmd.com/read/29706899/development-of-the-human-placenta-and-fetal-heart-synergic-or-independent
#6
REVIEW
Graham J Burton, Eric Jauniaux
The placenta is the largest fetal organ, and toward the end of pregnancy the umbilical circulation receives at least 40% of the biventricular cardiac output. It is not surprising, therefore, that there are likely to be close haemodynamic links between the development of the placenta and the fetal heart. Development of the placenta is precocious, and in advance of that of the fetus. The placenta undergoes considerable remodeling at the end of the first trimester of pregnancy, and its vasculature is capable of adapting to environmental conditions and to variations in the blood supply received from the mother...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29705139/characteristics-treatment-decisions-and-outcomes-of-prepubertal-testicular-germ-cell-tumor-a-descriptive-analysis-from-a-large-chinese-center
#7
P Liu, W Li, H C Song, L L Jiao, W P Zhang, N Sun
INTRODUCTION: Prepubertal testicular tumors are fundamentally distinct from their postpubertal and adult counterparts. Racial and ethnic differences contribute to the incidence, characteristics, and histological distribution of prepubertal testicular germ cell tumors (PTGCTs). OBJECTIVE: To elucidate the characteristics and treatment outcomes of PTGCTs in a Chinese cohort. STUDY DESIGN: Data were retrospectively reviewed from consecutive PTGCT patients aged <12 years who received treatment at the current institution from January 2007 to December 2015...
April 3, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29704636/decreased-microglial-numbers-in-vav1-cre-dicer-knock-out-mice-suggest-a-second-source-of-microglia-beyond-yolk-sac-macrophages
#8
M K Fehrenbach, M Tjwa, I Bechmann, M Krueger
Microglia represent the resident macrophages of the central nervous system (CNS). While it is clear that microglia recruitment is established by differentiation of primitive yolk sac (YS) macrophages and consecutive invasion of the brain, starting around E8 in rodents (Ginhoux et al., 2010), more recent studies suggest that a non-YS contribution to the microglia population should not entirely be dismissed (Swinnen et al., 2013; Xu et al., 2015). Therefore, we used Vav1-Cre+ :dicer knock-out mice in order to study the effect of the post-YS hematopoiesis on the definitive microglial population in late prenatal (E16...
April 25, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29691861/the-effect-of-substrate-rearing-on-growth-aerobic-scope-and-physiology-of-larval-white-sturgeon-acipenser-transmontanus
#9
M A Boucher, D W Baker, C J Brauner, J M Shrimpton
The effect of substratum on growth and metabolic rate was assessed in larval white sturgeon Acipenser transmontanus. Yolk-sac larvae (YSL) were reared in bare tanks or tanks with gravel as substratum from hatch until approximately 16 days post hatch (dph). The effect of an artificial substratum was also evaluated on growth alone. Substratum had a significant effect on mass, with larvae reared in gravel and artificial substrata being larger than those reared without substratum. Routine metabolic rates were significantly lower and relative aerobic scope (the difference between maximum and routine metabolic rate) was significantly higher for YSL and feeding larvae (FL) reared in gravel relative to those reared in bare tanks, particularly before fish started feeding exogenously...
April 24, 2018: Journal of Fish Biology
https://www.readbyqxmd.com/read/29677525/insights-from-diversified-anti-angiogenic-models-role-of-%C3%AE-interferon-inducer-deae-dextran
#10
Anita K Bakrania, Bhavesh C Variya, Snehal S Patel
BACKGROUND: Angiogenesis, the physiological process involving growth of new blood vessels from preexisting vessels, is essential for organ growth and repair. However, the imbalance in angiogenesis contributes to copious pathologies including cancer. Preceding the development of anti-angiogenic or proangiogenic agents, its evaluation is equally imperative; hence, precise and adequate models required. Valid mammalian models are expensive, time-consuming and not easy to set up, instigating legal and ethical aspects making it necessary to establish models with satisfactory activity and limited drawbacks...
April 17, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29675930/relationship-between-ultrasonographic-and-biochemical-markers-of-tubal-ectopic-pregnancy-and-success-of-subsequent-management
#11
Batool Nadim, Chuan Lu, Fernando Infante, Shannon Reid, George Condous
OBJECTIVES: To determine whether there is an association between morphologic types of tubal ectopic pregnancy (EP), 0-hour human chorionic gonadotropin (hCG) levels, and subsequent management success. METHODS: We conducted a prospective study (November 2006-December 2015). Women had a diagnosis of EP by transvaginal ultrasonography if they had an inhomogeneous mass adjacent to the ovary and moving separately from it ("blob" sign), a mass with a hyperechoic ring around the gestational sac ("bagel" sign), or a gestational sac with an embryonic pole with or without a yolk sac with or without cardiac activity...
April 20, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29672853/morphological-development-in-the-first-life-phase-of-adriatic-sturgeon-acipenser-naccarii-under-controlled-conditions
#12
R Cabrera-Castro, C Zabala, M C Soriguer, A Domezain, J A Hernando
Early development of the Adriatic sturgeon Acipenser naccarii from its free embryo after hatching (stage 36), until late embryo stage, when the transition to exogenous feeding starts (stage 45) is described. Special emphasis is given to morphological development and description of the different structures that are formed at each life stage. After hatching, free embryos still present embryonic characteristics, little pigmentation and an ovoid yolk sac. The mouth begins to open on the 2nd day post hatch (dph) and is fully open at 3 dph...
April 19, 2018: Journal of Fish Biology
https://www.readbyqxmd.com/read/29668739/physiochemical-characterization-and-cytotoxicity-evaluation-of-mercury-based-formulation-for-the-development-of-anticancer-therapeuticals
#13
Kannan N, Shanmuga Sundar S, Balaji S, Arul Amuthan, Anil Kumar Nv, Balasubramanian N
BACKGROUND: The present study is aimed to evaluate the physiochemical properties and cytotoxicity of mercury-based formulation for the development of anticancer therapeuticals. METHODS: The elemental and morphological features of the formulation were characterized by FE-SEM, XPS and EDS. The described formulation was evaluated for its cytotoxicity on Hek293 and MCF7 cell lines using MTT assay to study the in vitro effects. The in vivo developmental toxicity was also studied on zebrafish embryos and the lethal concentration (LC50) values were calculated as per the OECD regulations...
2018: PloS One
https://www.readbyqxmd.com/read/29665425/omega-3-polyunsaturated-fatty-acids-promotes-angiogenesis-in-placenta-derived-mesenchymal-stromal-cells
#14
Suja Ann Mathew, Ramesh Bhonde
Enhancement of angiogenesis is solicited in wound repair and regeneration. Mesenchymal stromal cells derived from the placenta (P-MSCs) have an inherent angiogenic potential. Polyunsaturated fatty acids (PUFAs) in turn, specifically the omega-3 (N-3) are essential for growth and development. They are also recommended as dietary supplements during pregnancy. We therefore hypothesized that addition of N-3 PUFAs in P-MSC culture media may enhance their angiogenic potential. Hence we treated P-MSCs with omega-3 (N-3) fatty acids -Docosahexaenoic acid (DHA) and Eicosapentaenoic acid (EPA) at different concentrations and tested their angiogenic potential...
April 14, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29664838/ovarian-yolk-sac-tumors-does-age-matter-erratum
#15
(no author information available yet)
No abstract text is available yet for this article.
April 16, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29660108/early-development-of-the-longsnout-seahorse-hippocampus-reidi-syngnathidae-within-the-male-brood-pouch
#16
B Novelli, F Otero Ferrer, J A Socorro, L Molina Domínguez
Fertilized and unfertilized eggs and embryos of the longsnout seahorse Hippocampus reidi were collected at different stages of development and provided the basis for a description of morphological development from fertilization until release from the paternal pouch. Images of fertilized eggs, as well as their rupture after a few minutes in seawater are reported for the first time. The yolk sac transitioned from ovoid to spherical shape and was reabsorbed progressively until release. The tail began rising from the surface of the deuteroplasm while embryos were in the egg envelope...
April 16, 2018: Journal of Fish Biology
https://www.readbyqxmd.com/read/29627927/the-effects-of-roundup-on-gametes-and-early-development-of-common-carp-cyprinus-carpio-l
#17
Katarzyna Lugowska
To determine the effects of Roundup, a commercial formulation of glyphosate, gametes, and embryos of common carp (Cyprinus carpio L) was exposed to wide range of herbicide concentrations (0.0, 0.1, 0.5, 2.0, 5.0, 10.0, 20.0, and 50.0 mg/l). The obtained results showed different effects of Roundup on common carp gametes. Herbicide reduced swelling of eggs (but the effect was not concentration-related), while sperm showed low sensitivity to Roundup (time of spermatozoa motility was reduced in a significant way only at 20 mg/l, and at remaining concentrations, only a slight tendency was observed)...
April 7, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29627477/distribution-of-mannose-receptor-in-blunt-snout-bream-megalobrama-amblycephala-during-the-embryonic-development-and-its-immune-response-to-the-challenge-of-aeromonas-hydrophila
#18
Changsong Wu, Xiaoheng Zhao, Sarath Babu V, Gailing Yuan, Weimin Wang, Jianguo Su, Xiaoling Liu, Li Lin
The mannose receptor (MR) is a type I transmembrane protein. Its ectodomain has eight C-type lectin-like domains, which are able to recognize and mediate the phagocytosis of a wide range of pathogens. Comprehensive studies have revealed that mammalian MR is widely distributed in the mononuclear phagocyte system (MPS, previously known as the reticuloendothelial system) and play a key role both in the physiological clearance and cell activation. Hitherto, neither the MR distribution, nor the function of clearance and cell activation has been investigated in fish...
April 6, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29624691/early-developmental-and-allometric-patterns-in-the-electric-yellow-cichlid-labidochromis-caeruleus
#19
M Saemi-Komsari, H Mousavi-Sabet, C F Kratochwil, M Sattari, S Eagderi, A Meyer
The electric yellow cichlid Labidochromis caeruleus is a mouth-brooding haplochromine cichlid from Lake Malawi and one of the most popular cichlids in the ornamental fish industry. To investigate the early development of L. caeruleus from hatching until the juvenile stage, we studied its morphological development and allometric growth patterns. In newly-hatched larvae, most organs and body parts were not yet differentiated and continued to develop until 15 days post hatching (dph). The yolk sac was depleted at 13 dph...
April 6, 2018: Journal of Fish Biology
https://www.readbyqxmd.com/read/29618843/rudhira-bcas3-is-essential-for-mouse-development-and-cardiovascular-patterning
#20
Ronak Shetty, Divyesh Joshi, Mamta Jain, Madavan Vasudevan, Jasper Chrysolite Paul, Ganesh Bhat, Poulomi Banerjee, Takaya Abe, Hiroshi Kiyonari, K VijayRaghavan, Maneesha S Inamdar
Rudhira/Breast Carcinoma Amplified Sequence 3 (BCAS3) is a cytoskeletal protein that promotes directional cell migration and angiogenesis in vitro and is implicated in human carcinomas and coronary artery disease. To study the role of Rudhira during development in vivo, we generated the first knockout mouse for rudhira and show that Rudhira is essential for mouse development. Rudhira null embryos die at embryonic day (E) 9.5 accompanied by severe vascular patterning defects in embryonic and extra-embryonic tissues...
April 4, 2018: Scientific Reports
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