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https://www.readbyqxmd.com/read/29166148/in-vivo-differentiation-of-uric-acid-versus-non-uric-acid-urinary-calculi-with-third-generation-dual-source-dual-energy-ct-at-reduced-radiation-dose
#1
Axelle Franken, Pierre Alain Gevenois, Alain Van Muylem, Nigel Howarth, Caroline Keyzer
OBJECTIVE: The objective of our study was to evaluate in vivo urinary calculus characterization with third-generation dual-source dual-energy CT (DECT) at reduced versus standard radiation dose. SUBJECTS AND METHODS: One hundred fifty-three patients requiring unenhanced CT for suspected or known urolithiasis were prospectively included in our study. They underwent two acquisitions at reduced-dose CT (90 kV and 50 mAsref; Sn150 kV and 31 mAsref, where Sn denotes the interposition of a tin filter in the high-energy beam) and standard-dose CT (90 kV and 50 mAsref; Sn150 kV and 94 mAsref)...
November 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29157265/the-impact-of-dual-energy-ct-imaging-on-dose-calculations-for-pre-clinical-studies
#2
Ana Vaniqui, Lotte E J R Schyns, Isabel P Almeida, Brent van der Heyden, Stefan J van Hoof, Frank Verhaegen
BACKGROUND: To investigate the feasibility of using dual-energy CT (DECT) for tissue segmentation and kilovolt (kV) dose calculations in pre-clinical studies and assess potential dose calculation accuracy gain. METHODS: Two phantoms and an ex-vivo mouse were scanned in a small animal irradiator with two distinct energies. Tissue segmentation was performed with the single-energy CT (SECT) and DECT methods. A number of different material maps was used. Dose calculations were performed to verify the impact of segmentations on the dose accuracy...
November 21, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29153358/impact-of-noise-optimized-virtual-monoenergetic-dual-energy-computed-tomography-on-image-quality-in-patients-with-renal-cell-carcinoma
#3
Simon S Martin, Julian L Wichmann, Sophia Pfeifer, Doris Leithner, Lukas Lenga, Michael A Reynolds, Tommaso D'Angelo, Renate Hammerstingl, Tatjana Gruber-Rouh, Thomas J Vogl, Moritz H Albrecht
OBJECTIVE: The aim of this study was to evaluate the impact of a noise-optimized virtual monoenergetic imaging (VMI+) reconstruction technique on image quality and lesion delineation in patients with renal cell carcinoma (RCC) undergoing abdominal dual-energy computed tomography (DECT). MATERIALS AND METHODS: Fifty-two patients (33 men; 61.5±13.6years) with RCC underwent contrast-enhanced DECT during the corticomedullary and nephrogenic phase of renal enhancement...
December 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29146741/presence-of-monosodium-urate-crystal-deposition-by-dual-energy-ct-in-patients-with-gout-treated-with-allopurinol
#4
Nicola Dalbeth, Savvas Nicolaou, Scott Baumgartner, Jia Hu, Maple Fung, Hyon K Choi
OBJECTIVE: Dual-energy CT (DECT) detects and quantifies monosodium urate (MSU) crystal deposition with high precision. This DECT study assessed crystal deposition in patients with gout treated with stable-dose allopurinol, and investigated potential clinical determinants for crystal deposition. METHODS: Patients with gout treated with allopurinol ≥300 mg daily for at least 3 months were prospectively recruited from the USA and New Zealand, using monitored enrolment to include approximately 25% patients with palpable tophi and approximately 50% with serum urate (sUA) levels <6...
November 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29144020/combining-click-sulfur-vi-fluoride-exchange-with-photoiniferters-a-facile-fast-and-efficient-strategy-for-postpolymerization-modification
#5
Peixi Wang, Yishi Dong, Xiaowen Lu, Zhaoqiang Wu, Hong Chen
"Click" type reactions represent the currently most prevalent postpolymerization strategy for the preparation of functional polymeric materials. Herein, a novel photoiniferter agent 4-(fluorosulfonyl)benzyl diethylcarbamodithioate (FSB-DECT) containing both dithiocarbamates and sulfonyl fluoride moieties is developed to act as both photoinitiator and click sulfur(VI)-fluoride exchange (SuFEx) agent. The photopolymerization behavior of FSB-DECT is demonstrated via standard photoiniferter-mediated polymerization for various types of monomer including N-isopropylacrylamide (NIPAAm), glycidyl methacrylate, and vinyl acetate (VAc)...
November 16, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29134674/experimental-validation-of-two-dual-energy-ct-methods-for-proton-therapy-using-heterogeneous-tissue-samples
#6
Esther Bär, Arthur Lalonde, Rongxiao Zhang, Kyung-Wook Jee, Kai Yang, Gregory Sharp, Bob Liu, Gary Royle, Hugo Bouchard, Hsiao-Ming Lu
PURPOSE: The purpose of this work is to evaluate the performance of dual-energy CT (DECT) for determining proton stopping power ratios (SPRs) in an experimental environment and to demonstrate its potential advantages over conventional single-energy CT (SECT) in clinical conditions. METHODS: Water equivalent range (WER) measurements of 12 tissue-equivalent plastic materials and 12 fresh animal tissue samples are performed in a 195 MeV broad proton beam using the dose extinction method...
November 14, 2017: Medical Physics
https://www.readbyqxmd.com/read/29127998/spectral-computed-tomography-technique-and-applications-for-head-and-neck-cancer
#7
REVIEW
Almudena Pérez-Lara, Reza Forghani
Spectral computed tomography (CT) or dual-energy CT (DECT) is an advanced form of CT with increasing applications in head and neck radiology. This article provides an overview of the DECT technique and reviews current applications for the evaluation of neck pathology, focusing on oncologic applications. Included are an overview of the basic underlying principles and approaches for DECT scan acquisition and material characterization; a discussion of various DECT reconstructions and a brief overview of practical issues pertaining to DECT implementation, including those related to workflow impact of DECT; and a discussion of various applications of DECT for the evaluation of the neck, especially in oncology...
February 2018: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/29125334/submillisievert-chest-dual-energy-computed-tomography-a-pilot-study
#8
Rodrigo Canellas, Jeanne B Ackman, Subba R Digumarthy, Melissa Price, Alexi Otrakji, Shaunagh McDermott, Amita Sharma, Mannudeep K Kalra
OBJECTIVE: To assess if diagnostic dual energy CT of the chest can be achieved at submillisievert doses (sub-mSv). METHODS: Our IRB-approved prospective study included 20 patients who were scanned on dual-source MDCT. All patients gave written informed consent for acquisition of additional image series at reduced radiation dose on a dual-source MDCT (80/140kV) within 10 seconds after the standard of care acquisition. Dose reduction was achieved by reducing the quality reference mAs, with combined angular exposure control...
November 10, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29119457/dual-energy-computed-tomography-for-the-head
#9
REVIEW
Norihito Naruto, Toshihide Itoh, Kyo Noguchi
Dual energy CT (DECT) is a promising technology that provides better diagnostic accuracy in several brain diseases. DECT can generate various types of CT images from a single acquisition data set at high kV and low kV based on material decomposition algorithms. The two-material decomposition algorithm can separate bone/calcification from iodine accurately. The three-material decomposition algorithm can generate a virtual non-contrast image, which helps to identify conditions such as brain hemorrhage. A virtual monochromatic image has the potential to eliminate metal artifacts by reducing beam-hardening effects...
November 9, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29111386/method-for-determining-the-half-value-layer-in-computed-tomography-scans-using-a-real-time-dosimeter-application-to-dual-source-dual-energy-acquisition
#10
Kosuke Matsubara, Hiroji Nagata, Rena Okubo, Tadanori Takata, Masanao Kobayashi
PURPOSE: We have proposed a method for determining the half-value layers (HVL) in dual-source dual-energy computed tomography (DS-DECT) scans without the need for the X-ray tubes to be fixed. METHODS: A custom-made lead-covered case and an ionizing chamber connected with a multi-function digitizer module (a real-time dosimeter) were used. The chamber was placed in the center of the case, and aluminum or copper filters were placed in front of the aperture. The HVL was measured using aperture widths of 1...
October 27, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29102938/clinical-impact-of-rest-dual-energy-computed-tomography-myocardial-perfusion-in-patients-with-coronary-artery-disease
#11
Stefan Baumann, Marlon Rutsch, Tobias Becher, Philipp Kryeziu, Holger Haubenreisser, Nils Vogler, Celi Anne Schoenike, Martin Borggrefe, Stefan O Schoenberg, Ibrahim Akin, Thomas Henzler, Dirk Lossnitzer
BACKGROUND/AIM: To evaluate the hypothesis that patients with suspected coronary artery disease (CAD) assessed using rest dual-energy computed tomography-derived myocardial perfusion imaging (DECT-P), could have fewer invasive coronary angiographies (ICA), showing non-obstructive CAD. MATERIALS AND METHODS: Patients who had undergone coronary computed tomography angiography (cCTA), rest DECT-P and ICA were analyzed. RESULTS: We evaluated 51 patients (62...
November 2017: In Vivo
https://www.readbyqxmd.com/read/29079119/evaluation-of-stopping-power-prediction-by-dual-and-single-energy-computed-tomography-in-an-anthropomorphic-ground-truth-phantom
#12
Patrick Wohlfahrt, Christian Möhler, Christian Richter, Steffen Greilich
PURPOSE: To determine the accuracy of particle range prediction for proton and heavier ion radiation therapy based on dual-energy computed tomography (DECT) in a realistic inhomogeneous geometry and to compare it with the state-of-the-art clinical approach. METHODS AND MATERIALS: A 3-dimensional ground-truth map of stopping-power ratios (SPRs) was created for an anthropomorphic head phantom by assigning measured SPR values to segmented structures in a high-resolution CT scan...
September 18, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29063254/dual-layer-dect-for-multiphasic-hepatic-ct-with-50-percent-iodine-load-a-matched-pair-comparison-with-a-120%C3%A2-kvp-protocol
#13
Yasunori Nagayama, Takeshi Nakaura, Seitaro Oda, Daisuke Utsunomiya, Yoshinori Funama, Yuji Iyama, Narumi Taguchi, Tomohiro Namimoto, Hideaki Yuki, Masafumi Kidoh, Kenichiro Hirata, Masataka Nakagawa, Yasuyuki Yamashita
OBJECTIVES: To evaluate the image quality and lesion conspicuity of virtual-monochromatic-imaging (VMI) with dual-layer DECT (DL-DECT) for reduced-iodine-load multiphasic-hepatic CT. METHODS: Forty-five adults with renal dysfunction who had undergone hepatic DL-DECT with 300-mgI/kg were included. VMI (40-70-keV, DL-DECT-VMI) was generated at each enhancement phase. As controls, 45 matched patients undergoing standard 120-kVp protocol (120-kVp, 600-mgI/kg, and iterative reconstruction) were included...
October 23, 2017: European Radiology
https://www.readbyqxmd.com/read/29059051/extension-of-the-fermi-eyges-most-likely-path-in-heterogeneous-medium-with-prior-knowledge-information
#14
Charles-Antoine Collins-Fekete, Esther Bär, Lennart Volz, Hugo Bouchard, Luc Beaulieu, Joao Seco
Particle imaging suffers from poor spatial resolution due to the multiple Coulomb scattering deflections undergone by the particles throughout their path. To account for these deflections, a most-likely path (MLP) formalism was developed based on a Bayesian adaption of the Fermi-Eyges theory. Previous work calculated the MLP formalism in a homogeneous water medium as an initial estimate. However, this potentially reduces the accuracy of the MLP estimate as well as the achievable resolution of the subsequent tomographic reconstruction...
October 23, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29057753/validation-of-proton-stopping-power-ratio-estimation-based-on-dual-energy-ct-using-fresh-tissue-samples
#15
Vicki Trier Taasti, Gregory James Michalak, David C Hansen, Amanda Deisher, Jon J Kruse, Bernhard Krauss, Ludvig Paul Muren, Jørgen Breede Baltzer Petersen, Cynthia H McCollough
Dual energy CT (DECT) has been shown, in theoretical and phantom studies, to improve the stopping power ratio (SPR) determination used for proton treatment planning compared to the use of single energy CT (SECT). However, it has not been shown that this also extends to organic tissues. The purpose of this study was therefore to investigate the accuracy of SPR estimation for fresh pork and beef tissue samples used as surrogates of human tissues. The reference SPRs for fourteen tissue samples, which included fat, muscle and femur bone, were measured using proton pencil beams...
October 23, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29050958/metal-artefact-reduction-for-accurate-tumour-delineation-in-radiotherapy
#16
David Gergely Kovacs, Laura A Rechner, Ane L Appelt, Anne K Berthelsen, Junia C Costa, Jeppe Friborg, Gitte F Persson, Jens Peter Bangsgaard, Lena Specht, Marianne C Aznar
BACKGROUND AND PURPOSE: Two techniques for metal artefact reduction for computed tomography were studied in order to identify their impact on tumour delineation in radiotherapy. MATERIALS AND METHODS: Using specially designed phantoms containing metal implants (dental, spine and hip) as well as patient images, we investigated the impact of two methods for metal artefact reduction on (A) the size and severity of metal artefacts and the accuracy of Hounsfield Unit (HU) representation, (B) the visual impact of metal artefacts on image quality and (C) delineation accuracy...
October 16, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29050953/dual-energy-ct-based-proton-range-prediction-in-head-and-pelvic-tumor-patients
#17
Patrick Wohlfahrt, Christian Möhler, Kristin Stützer, Steffen Greilich, Christian Richter
BACKGROUND AND PURPOSE: To reduce range uncertainty in particle therapy, an accurate computation of stopping-power ratios (SPRs) based on computed tomography (CT) is crucial. Here, we assess range differences between the state-of-the-art CT-number-to-SPR conversion using a generic Hounsfield look-up table (HLUT) and a direct patient-specific SPR prediction (RhoSigma) based on dual-energy CT (DECT) in 100 proton treatment fields. MATERIAL AND METHODS: For 25 head-tumor and 25 prostate-cancer patients, the clinically applied treatment plan, optimized using a HLUT, was recalculated with RhoSigma as CT-number-to-SPR conversion...
October 16, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29028510/comparison-of-virtual-monochromatic-series-iodine-overlay-maps-and-single-energy-ct-equivalent-images-in-head-and-neck-cancer-conspicuity
#18
Michael Kraft, Mohannad Ibrahim, Matthew Spector, Reza Forghani, Ashok Srinivasan
OBJECTIVE: To compare lesion conspicuity amongst DECT monochromatic series (40, 45, 50keV), and single-energy CT (SECT) equivalent images in head and neck squamous cell carcinomas (HNSCC). METHODS: Two readers compared DECT images to 70keV SECT equivalent series in 39 patients with HNSCC on lesion margin, enhancement, and overall conspicuity. RESULTS: The 45keV and 50keV images were significantly better (p-values ≤0.001) than the SECT equivalent in lesion enhancement, margins, and overall conspicuity for both readers...
September 29, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28990974/iodine-and-fat-quantification-for-differentiation-of-adrenal-gland-adenomas-from-metastases-using-third-generation-dual-source-dual-energy-computed-tomography
#19
Simon S Martin, Sebastian Weidinger, Rouben Czwikla, Benjamin Kaltenbach, Moritz H Albrecht, Lukas Lenga, Thomas J Vogl, Julian L Wichmann
OBJECTIVES: The aim of this study was to investigate the value of third-generation dual-source dual-energy computed tomography (DECT) iodine and fat quantification in differentiating adrenal gland adenomas from metastases. MATERIALS AND METHODS: Sixty-two patients (38 men and 24 women; mean age, 69.1 years) underwent clinically indicated DECT of the abdomen on a third-generation dual-source scanner. Examinations were retrospectively included due to detected adrenal masses...
October 3, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28987684/material-density-iodine-images-in-dual-energy-ct-detection-and-characterization-of-hypervascular-liver-lesions-compared-to-magnetic-resonance-imaging
#20
Daniela Muenzel, Grace C Lo, Hei Shun Yu, Anushri Parakh, Manuel Patino, Avinash Kambadakone, Ernst J Rummeny, Dushyant V Sahani
PURPOSE: To determine the diagnostic potential of Material Density (MD) iodine images in dual-energy CT (DECT) for the detection and characterization of hypervascular liver lesions compared to monenergetic 65keV images, using MRI as the standard. MATERIALS AND METHODS: The study complied with HIPAA guidelines and was approved by the institutional review board. Fifty-two patients (36 men, 16 women; age range, 29-87 years) with 236 hypervascular liver lesions (benign, n=31; malignant, n=205; mean diameter, 29...
October 2017: European Journal of Radiology
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