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https://www.readbyqxmd.com/read/29339048/intrarenal-fat-deposition-does-not-interfere-with-the-measurement-of-single-kidney-perfusion-in-obese-swine-using-multi-detector-computed-tomography
#1
Christopher M Ferguson, Alfonso Eirin, Gregory J Michalak, Ahmad F Hedayat, Abdelrhman Abumoawad, Ahmed Saad, Xiangyang Zhu, Stephen C Textor, Cynthia H McCollough, Lilach O Lerman
BACKGROUND: Altered vascular structure or function in several diseases may impair renal perfusion. Multi-detector computed tomography (MDCT) is a non-invasive tool to assess single-kidney perfusion and function based on dynamic changes in tissue attenuation during contrast media transit. However, changes in basal tissue attenuation might hamper these assessments, despite background subtraction. Evaluation of iodine concentration using the dual-energy (DECT) MDCT mode allows excluding effects of basal values on dynamic changes in tissue attenuation...
January 10, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29329150/comparison-of-iodine-density-measurement-among-dual-energy-computed-tomography-scanners-from-3-vendors
#2
Hyungjin Kim, Jin Mo Goo, Chang Kyung Kang, Kum Ju Chae, Chang Min Park
OBJECTIVES: The aims of this study were to analyze the effect of dual-energy computed tomography (DECT) scanners and fluid characteristics on iodine quantification and to calculate the measurement variability range induced by those variables. METHODS: We performed an experimental phantom study with 4 mediastinal iodine phantoms. Each phantom contained 6 tubes of different iodine concentrations (0, 1.0, 2.5, 5.0, 10.0, and 20.0 mg/mL) diluted in a specific solvent, which was water, 10% amino acid solution, 20% lipid emulsion, or 18% calcium solution, respectively...
January 12, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29312701/analysis-of-pulmonary-pure-ground-glass-nodule-in-enhanced-dual-energy-ct-imaging-for-predicting-invasive-adenocarcinoma-comparing-with-conventional-thin-section-ct-imaging
#3
Ying Zhang, Jian Tang, Jianrong Xu, Jiejun Cheng, Huawei Wu
Background: To investigate the value of dual energy computed tomography (DECT) parameters (including iodine concentration and monochromatic CT numbers) for predicting pure ground-glass nodules (pGGNs) of invasive adenocarcinoma (IA). Methods: A total of 55 resected pGGNs evaluated with both unenhanced thin-section CT (TSCT) and enhanced DECT scans were included. Correlations between histopathology [adenocarcinoma in situ (AIS), minimally IA (MIA), and IA] and CT scan characteristics were examined...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29277821/iodine-content-analysis-using-dual-energy-computed-tomography-as-a-biomarker-of-transitional-cell-carcinoma-an-experience-with-separation-of-the-clotted-blood-and-tumorous-tissue
#4
Hynek Mirka, Jan Baxa, Milan Hora, Ondrej Hes, Ondrej Topolcan, Jiri Ferda
BACKGROUND/AIM: The aim of this study was to evaluate the possibility to discriminate the blood clot from tumorous tissue in the assessment of transitional cell carcinoma (TCC), when CT data are used only from single-phase dual-energy CT (DECT). MATERIALS AND METHODS: A total of 18 patients were included into the retrospective analysis of the prospectively collected data (the average age was 67.3 years, range=62-79 years, 12 males, 6 females). DECT was performed in all patients after intravenous administration of the iodinated contrast material...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29260727/dosimetric-impact-of-dual-energy-ct-tissue-segmentation-for-low-energy-prostate-brachytherapy-a-monte-carlo-study
#5
Charlotte Remy, Arthur Lalonde, Dominic Béliveau-Nadeau, Jean-Francois Carrier, Hugo Bouchard
{\color{red}The purpose of this study is} to evaluate the impact of a novel tissue characterization method using dual-energy over single-energy computed tomography (DECT and SECT) on Monte Carlo (MC) dose calculations for low-dose rate (LDR) prostate brachytherapy performed in a patient like geometry. A virtual patient geometry is created using contours from a real patient pelvis CT scan, where known elemental compositions and varying densities are overwritten in each voxel. A second phantom is made with additional calcifications...
December 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29242134/non-contrast-estimation-of-diffuse-myocardial-fibrosis-with-dual-energy-ct-a-phantom-study
#6
Vidhya Kumar, Kevin E McElhanon, James K Min, Xin He, Zhaobin Xu, Eric X Beck, Orlando P Simonetti, Noah Weisleder, Subha V Raman
BACKGROUND: Estimation of diffuse myocardial fibrosis, substrate for adverse events such as heart failure and arrhythmias in patients with various cardiac disorders, is presently done by histopathology or cardiac magnetic resonance. We sought to develop a non-contrast method to estimate the amount of diffuse myocardial fibrosis leveraging dual energy computed tomography (DECT) in phantoms and a suitable small animal model. METHODS AND RESULTS: Phantoms consisted of homogenized bovine myocardium with varying amounts of Type 1 collagen...
December 5, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29241277/dual-energy-computed-tomography-in-musculoskeletal-imaging-with-focus-on-fragility-fractures-of-the-pelvis
#7
Carsten Hackenbroch, Hans-Joachim Riesner, Patricia Lang, Fabian Stuby, Meinrad Beer, Benedikt Friemert, Hans-Georg Palm
Dual energy computed tomography (DECT) is a constantly evolving technology, which opens up new diagnostic possibilities. It is particularly valuable for musculoskeletal (MSK) imaging. Due to the lack of recognition and availability of dual energy scanners, routine use is only established in a few centres. The intention of this review is to show the possibilities and fields of applications of the DECT in MSK imaging, as well as to describe technical principles and typical indications. We mainly focus on the use of DECT in the context of fragility fractures of the pelvis...
December 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29239855/experimental-verification-of-stopping-power-prediction-from-single-and-dual-energy-computed-tomography-in-biological-tissues
#8
Christian Möhler, Tom Russ, Patrick Wohlfahrt, Alina Elter, Armin Runz, Christian Richter, Steffen Greilich
An experimental setup for consecutive measurement of ion and x-ray absorption in tissue or other materials is introduced. With this setup using a 3D-printed sample container, the reference stopping-power ratio (SPR) of materials can be measured with an uncertainty of below 0.1%. A total of 65 porcine and bovine tissue samples were prepared for measurement, comprising five samples each of 13 tissue types representing about 80% of the total body mass (three different muscle and fatty tissues, liver, kidney, brain, heart, blood, lung and bone)...
December 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29234002/dual-energy-micro-ct-for-quantifying-the-time-course-and-staining-characteristics-of-ex-vivo-animal-organs-treated-with-iodine-and-gadolinium-based-contrast-agents
#9
Juliana Martins de Souza E Silva, Julian Utsch, Melanie A Kimm, Sebastian Allner, Michael F Epple, Klaus Achterhold, Franz Pfeiffer
Chemical staining of soft-tissues can be used as a strategy to increase their low inherent contrast in X-ray absorption micro-computed tomography (micro-CT), allowing to obtain fast three-dimensional structural information of animal organs. Though some staining agents are commonly used in this context, little is known about the staining agents' ability to stain specific types of tissues; the times necessary to provide a sufficient contrast; and the effect of staining solution in distorting the tissue. Here we contribute to studies of animal organs (mouse heart and lungs) using staining combined with dual-energy micro-CT (DECT)...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29220708/comparative-diagnostic-accuracy-of-dual-energy-ct-myocardial-perfusion-imaging-by-monochromatic-energy-versus-material-decomposition-methods
#10
Ibrahim Danad, Iksung Cho, Kimberly Elmore, Joshua Schulman-Marcus, Bríain Ó Hartaigh, Wijnand J Stuijfzand, Patricia Carrascosa, James K Min
PURPOSE: To compare the diagnostic value of monochromatic and material decomposition (MD) dual- energy computed tomography (DECT) imaging for the evaluation of ischemia. METHODS: Patients with suspected coronary artery disease underwent rest-stress DECT and SPECT perfusion imaging. DECT images were reconstructed between 40 and 140keV and through MD of iodine/muscle. RESULTS: MD and monochromatic imaging had a sensitivity, specificity, negative predictive, positive predictive value, and accuracy of 89%, 40%, 67%, 73% and 71%; and 91%, 67%, 67%, 91% and 86%, respectively (p=0...
November 11, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29168007/can-dual-energy-ct-replace-perfusion-ct-for-the-functional-evaluation-of-advanced-hepatocellular-carcinoma
#11
Sébastien Mulé, Frédéric Pigneur, Ronan Quelever, Arthur Tenenhaus, Laurence Baranes, Philippe Richard, Vania Tacher, Edouard Herin, Hugo Pasquier, Maxime Ronot, Alain Rahmouni, Valérie Vilgrain, Alain Luciani
OBJECTIVES: To determine the degree of relationship between iodine concentrations derived from dual-energy CT (DECT) and perfusion CT parameters in patients with advanced HCC under treatment. METHODS: In this single-centre IRB approved study, 16 patients with advanced HCC treated with sorafenib or radioembolization who underwent concurrent dynamic perfusion CT and multiphase DECT using a single source, fast kV switching DECT scanner were included. Written informed consent was obtained for all patients...
November 22, 2017: European Radiology
https://www.readbyqxmd.com/read/29166148/in-vivo-differentiation-of-uric-acid-versus-non-uric-acid-urinary-calculi-with-third-generation-dual-source-dual-energy-ct-at-reduced-radiation-dose
#12
Axelle Franken, Pierre Alain Gevenois, Alain Van Muylem, Nigel Howarth, Caroline Keyzer
OBJECTIVE: The objective of our study was to evaluate in vivo urinary calculus characterization with third-generation dual-source dual-energy CT (DECT) at reduced versus standard radiation dose. SUBJECTS AND METHODS: One hundred fifty-three patients requiring unenhanced CT for suspected or known urolithiasis were prospectively included in our study. They underwent two acquisitions at reduced-dose CT (90 kV and 50 mAsref; Sn150 kV and 31 mAsref, where Sn denotes the interposition of a tin filter in the high-energy beam) and standard-dose CT (90 kV and 50 mAsref; Sn150 kV and 94 mAsref)...
November 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29157265/the-impact-of-dual-energy-ct-imaging-on-dose-calculations-for-pre-clinical-studies
#13
Ana Vaniqui, Lotte E J R Schyns, Isabel P Almeida, Brent van der Heyden, Stefan J van Hoof, Frank Verhaegen
BACKGROUND: To investigate the feasibility of using dual-energy CT (DECT) for tissue segmentation and kilovolt (kV) dose calculations in pre-clinical studies and assess potential dose calculation accuracy gain. METHODS: Two phantoms and an ex-vivo mouse were scanned in a small animal irradiator with two distinct energies. Tissue segmentation was performed with the single-energy CT (SECT) and DECT methods. A number of different material maps was used. Dose calculations were performed to verify the impact of segmentations on the dose accuracy...
November 21, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29153358/impact-of-noise-optimized-virtual-monoenergetic-dual-energy-computed-tomography-on-image-quality-in-patients-with-renal-cell-carcinoma
#14
Simon S Martin, Julian L Wichmann, Sophia Pfeifer, Doris Leithner, Lukas Lenga, Michael A Reynolds, Tommaso D'Angelo, Renate Hammerstingl, Tatjana Gruber-Rouh, Thomas J Vogl, Moritz H Albrecht
OBJECTIVE: The aim of this study was to evaluate the impact of a noise-optimized virtual monoenergetic imaging (VMI+) reconstruction technique on image quality and lesion delineation in patients with renal cell carcinoma (RCC) undergoing abdominal dual-energy computed tomography (DECT). MATERIALS AND METHODS: Fifty-two patients (33 men; 61.5±13.6years) with RCC underwent contrast-enhanced DECT during the corticomedullary and nephrogenic phase of renal enhancement...
December 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29146741/presence-of-monosodium-urate-crystal-deposition-by-dual-energy-ct-in-patients-with-gout-treated-with-allopurinol
#15
Nicola Dalbeth, Savvas Nicolaou, Scott Baumgartner, Jia Hu, Maple Fung, Hyon K Choi
OBJECTIVE: Dual-energy CT (DECT) detects and quantifies monosodium urate (MSU) crystal deposition with high precision. This DECT study assessed crystal deposition in patients with gout treated with stable-dose allopurinol, and investigated potential clinical determinants for crystal deposition. METHODS: Patients with gout treated with allopurinol ≥300 mg daily for at least 3 months were prospectively recruited from the USA and New Zealand, using monitored enrolment to include approximately 25% patients with palpable tophi and approximately 50% with serum urate (sUA) levels <6...
November 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29144020/combining-click-sulfur-vi-fluoride-exchange-with-photoiniferters-a-facile-fast-and-efficient-strategy-for-postpolymerization-modification
#16
Peixi Wang, Yishi Dong, Xiaowen Lu, Zhaoqiang Wu, Hong Chen
"Click" type reactions represent the currently most prevalent postpolymerization strategy for the preparation of functional polymeric materials. Herein, a novel photoiniferter agent 4-(fluorosulfonyl)benzyl diethylcarbamodithioate (FSB-DECT) containing both dithiocarbamates and sulfonyl fluoride moieties is developed to act as both photoinitiator and click sulfur(VI)-fluoride exchange (SuFEx) agent. The photopolymerization behavior of FSB-DECT is demonstrated via standard photoiniferter-mediated polymerization for various types of monomer including N-isopropylacrylamide (NIPAAm), glycidyl methacrylate, and vinyl acetate (VAc)...
November 16, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29134674/experimental-validation-of-two-dual-energy-ct-methods-for-proton-therapy-using-heterogeneous-tissue-samples
#17
Esther Bär, Arthur Lalonde, Rongxiao Zhang, Kyung-Wook Jee, Kai Yang, Gregory Sharp, Bob Liu, Gary Royle, Hugo Bouchard, Hsiao-Ming Lu
PURPOSE: The purpose of this work is to evaluate the performance of dual-energy CT (DECT) for determining proton stopping power ratios (SPRs) in an experimental environment and to demonstrate its potential advantages over conventional single-energy CT (SECT) in clinical conditions. METHODS: Water equivalent range (WER) measurements of 12 tissue-equivalent plastic materials and 12 fresh animal tissue samples are performed in a 195 MeV broad proton beam using the dose extinction method...
November 14, 2017: Medical Physics
https://www.readbyqxmd.com/read/29127998/spectral-computed-tomography-technique-and-applications-for-head-and-neck-cancer
#18
REVIEW
Almudena Pérez-Lara, Reza Forghani
Spectral computed tomography (CT) or dual-energy CT (DECT) is an advanced form of CT with increasing applications in head and neck radiology. This article provides an overview of the DECT technique and reviews current applications for the evaluation of neck pathology, focusing on oncologic applications. Included are an overview of the basic underlying principles and approaches for DECT scan acquisition and material characterization; a discussion of various DECT reconstructions and a brief overview of practical issues pertaining to DECT implementation, including those related to workflow impact of DECT; and a discussion of various applications of DECT for the evaluation of the neck, especially in oncology...
February 2018: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/29125334/submillisievert-chest-dual-energy-computed-tomography-a-pilot-study
#19
Rodrigo Canellas, Jeanne B Ackman, Subba R Digumarthy, Melissa Price, Alexi Otrakji, Shaunagh McDermott, Amita Sharma, Mannudeep K Kalra
OBJECTIVE: To assess if diagnostic dual energy CT of the chest can be achieved at submillisievert doses (sub-mSv). METHODS: Our IRB-approved prospective study included 20 patients who were scanned on dual-source MDCT. All patients gave written informed consent for acquisition of additional image series at reduced radiation dose on a dual-source MDCT (80/140kV) within 10 seconds after the standard of care acquisition. Dose reduction was achieved by reducing the quality reference mAs, with combined angular exposure control...
November 10, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29119457/dual-energy-computed-tomography-for-the-head
#20
REVIEW
Norihito Naruto, Toshihide Itoh, Kyo Noguchi
Dual energy CT (DECT) is a promising technology that provides better diagnostic accuracy in several brain diseases. DECT can generate various types of CT images from a single acquisition data set at high kV and low kV based on material decomposition algorithms. The two-material decomposition algorithm can separate bone/calcification from iodine accurately. The three-material decomposition algorithm can generate a virtual non-contrast image, which helps to identify conditions such as brain hemorrhage. A virtual monochromatic image has the potential to eliminate metal artifacts by reducing beam-hardening effects...
November 9, 2017: Japanese Journal of Radiology
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