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Theodoros Tokas, Martin Habicher, Daniel Junker, Thomas Herrmann, Jan Peter Jessen, Thomas Knoll, Udo Nagele
PURPOSE: To evaluate the stone-free rates (SFRs) and stone clearance rates (SCRs) of extracorporeal shock-wave lithotripsy (SWL), retrograde intrarenal surgery (RIRS), and percutaneous nephrolitholapaxy (PCNL) according to non-contrast computer tomography (NCCT) findings. METHODS: Original articles were identified from PubMed. After exclusion of ineligible papers, twenty-three studies with 2494 cases were included in the review. RESULTS: Six SWL, five RIRS and eight PCNL studies were selected...
October 13, 2016: World Journal of Urology
Alaa E El-Sisi, Samia S Sokar, Sally E Abu-Risha, Hanaa A Ibrahim
Life threatening conditions characterized by renal ischemia/reperfusion (RIR) such as kidney transplantation, partial nephrectomy, renal artery angioplasty, cardiopulmonary bypass and aortic bypass surgery, continue to be among the most frequent causes of acute renal failure. The current study investigated the possible protective effects of tadalafil alone and in combination with diltiazem in experimentally-induced renal ischemia/reperfusion injury in rats. Possible underlying mechanisms were also investigated such as oxidative stress and inflammation...
October 10, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Mordechai Duvdevani
Endoscopic treatment is currently the mainstay of management for urolithiasis. The high effectiveness of PCNL is well documented in the literature, as are its complications. Bleeding during PCNL is directly related to the size of the dilatation.(1) Several minimally invasive refinements in percutaneous surgery have been made to reduce access related complications and bleeding rates.(2) This was achieved mainly by reducing tract diameter, but the advantage over standard PCNL has yet to be proven.(3) The effectiveness of RIRS is decreasing with increasing stone burden...
October 12, 2016: Journal of Endourology
Babak Javanmard, Amir Hossein Kashi, Mohammad Mohsen Mazloomfard, Anahita Ansari Jafari, Saeed Arefanian
PURPOSE: To compare outcomes of retrograde intrarenal surgery (RIRS) with extracorporeal shock wave lithotripsy (SWL) for stones ≤ 2 cm. MATERIALS AND METHODS: Patients who were diagnosed with kidney stones of ≤ 2 cm underwent RIRS or SWL in a parallel group randomized clinical trial with balanced randomization [1:1] from 2011 to 2014. The primary outcome of interest was stone free rate after a single session intervention. Patients were evaluated by ultrasonography and KUB at 1 and 3 months after the intervention for the presence of residual stone by a radiologist who was blinded to the study...
October 10, 2016: Urology Journal
Stefano Paolo Zanetti, Luca Boeri, Michele Catellani, Andrea Gallioli, Alberto Trinchieri, Kemal Sarica, Emanuele Montanari
OBJECTIVE: A wide selection of both anterograde and retrograde mini-invasive procedures exist for stones' treatment. The 2016 European Association of Urology (EAU) guidelines still don't univocally define a best option. Our purpose is to give an overview on some European Stone Centers' customs and to compare real life clinical practice with statements of opinion leaders and Guidelines. MATERIALS AND METHODS: In 2015 we performed a survey in 3 step about the spread of retrograde intrarenal surgery (RIRS) and percutaneous nephrolithotomy (PCNL) techniques among EAU Section of Urolithiasis (EULIS) members...
October 5, 2016: Archivio Italiano di Urologia, Andrologia
Arif Demirbas, Berkan Resorlu, Mehmet Melih Sunay, Tolga Karakan, Mehmet Ali Karagoz, Omer Gokhan Doluoglu
Purpose Comparison of effectiveness and safety of ultramini percutaneous nephrolithotomy (UMPNL) and retrograde intrarenal surgery (RIRS) in treatment of moderate-sized renal stones. Material and methods The patients scheduled for surgery due to renal stones with the greatest diameter of 10-25 mm were prospectively analyzed. Patients were randomized into groups with tossing a coin method. The patients that had UMPNL and RIRS were defined as Group I and Group II, respectively. The groups were compared for demograhic data, stone characteristics, operative and postoperative data, stone-free status, and the complications...
October 5, 2016: Journal of Endourology
Steven Hawken, Beth K Potter, Julian Little, Eric I Benchimol, Salah Mahmud, Robin Ducharme, Kumanan Wilson
BACKGROUND: The self-controlled case series (SCCS) is a useful design for investigating associations between outcomes and transient exposures. The SCCS design controls for all fixed covariates, but effect modification can still occur. This can be evaluated by including interaction terms in the model which, when exponentiated, can be interpreted as a relative incidence ratio (RIR): the change in relative incidence (RI) for a unit change in an effect modifier. METHODS: We conducted a scoping review to investigate the use of RIRs in published primary SCCS studies, and conducted a case-study in one of our own primary SCCS studies to illustrate the use of RIRs within an SCCS analysis to investigate subgroup effects in the context of comparing whole cell (wcp) and acellular (acp) pertussis vaccines...
2016: BMC Medical Research Methodology
Sedat Yahsi, Senol Tonyali, Cavit Ceylan, Kenan Y Yildiz, Levent Ozdal
A 34 year-old woman was admitted to our hospital with left flank pain. A non-contrast enhanced computerized tomography (NCCT) revealed a 1.5x2cm left proximal ureter stone. Patient was scheduled for ureterorenoscopy (URS) and stone removal. She was submitted to retrograde intrarenal surgery (RIRS). At the postoperative 1st day, the patient began to suffer from left flank pain. A NCCT was taken, which revealed a subcapsular hematoma and perirenal fluid. The patient was managed conservatively with intravenous fluid, antibiotic and non-steroidal anti-inflammatory drug therapy and was discharged at the postoperative 6th day...
September 20, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
F Berardinelli, L Cindolo, P De Francesco, S Proietti, D Hennessey, O Dalpiaz, C M Cracco, F Pellegrini, C M Scoffone, L Schips, G Giusti
The aim of this study is to evaluate if surgical experience could influence the outcomes of retrograde intrarenal surgery (RIRS) in terms of stone clearance and complication rate. Patients from five institutions were included in this study. Patients were divided into two groups. Group 1: patients treated by three surgeons in the early phase of learning curve (surgical experience <100 procedures); Group 2: cases operated by two surgeons with great endourological experience (>400 procedures). Patients and stone characteristics, outcome and complications were analyzed...
September 16, 2016: Urolithiasis
Salim Said Al Busaidy, Santhosh Narayana Kurukkal, Qais Mohamed Al Hooti, Mohammed Sdky Alsaraf, Said Abdallah Al Mamari, Ahmed Khamis Al Saeedi
INTRODUCTION: The European Association of Urology (EAU) and the American Urological Association (AUA) guidelines recommend percutaneous nephrolithotomy (PCNL) as the first-line treatment of renal stones greater than 20 mm, however multistage retrograde intrarenal stone surgery (RIRS) is reported to have high stone-free rates (SFR), fewer complications and a rapid learning curve. This study presents our experience of RIRS in the management of 2 cm-4 cm renal stones. MATERIALS AND METHODS: A retrospective study was performed of all patients who underwent RIRS for 2 cm-4 cm renal stones over a period of 22 months...
August 2016: Canadian Journal of Urology
Elizabeth M Boehm, M Todd Washington
Many proteins responsible for genome maintenance interact with one another via short sequence motifs. The best known of these are PIP motifs, which mediate interactions with the replication protein PCNA. Others include RIR motifs, which bind the translesion synthesis protein Rev1, and MIP motifs, which bind the mismatch repair protein Mlh1. Although these motifs have similar consensus sequences, they have traditionally been viewed as separate motifs, each with their own target protein. In this article, we review several recent studies that challenge this view...
August 19, 2016: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
Cindy Cen, Monowar Aziz, Weng-Lang Yang, Jeffrey M Nicastro, Gene F Coppa, Ping Wang
Renal ischemia-reperfusion (RIR) injury is a common occurrence after major surgery and shock, leading to acute kidney injury (AKI). Osteopontin (OPN) is a secreted glycoprotein that acts as a proinflammatory cytokine and activator of T lymphocytes. We hypothesized that blockade of OPN reduces the severity of inflammation and injury in RIR. Renal ischemia was induced in adult C57BL/6 mice via bilateral clamping of renal pedicles for 35 min, followed by reperfusion for 24 h. Anti-OPN antibody (Ab), non-immunized isotype IgG, or normal saline was injected intravenously at time of reperfusion...
August 8, 2016: Shock
Barteld N J Postma, Brian F G Katz
Various methods exist for room acoustic measurements. To increase the signal-to-noise-ratio (SNR), averaging of repeated room impulse responses (RIR) can be performed under the assumption of time-invariant systems. Associated with a study of the Paris Notre Dame cathedral, time-variances due to minute temperature changes were observed which confounded results of averaged RIRs, producing significantly shorter reverberation times. A correction method for such time-variance of the acoustic system is proposed, based on time-stretching...
July 2016: Journal of the Acoustical Society of America
Abdallah S R Mohamed, David I Rosenthal, Musaddiq J Awan, Adam S Garden, Esengul Kocak-Uzel, Abdelaziz M Belal, Ahmed G El-Gowily, Jack Phan, Beth M Beadle, G Brandon Gunn, Clifton D Fuller
BACKGROUND: The aim of this study is to develop a methodology to standardize the analysis and reporting of the patterns of loco-regional failure after IMRT of head and neck cancer. MATERIAL AND METHODS: Twenty-one patients with evidence of local and/or regional failure following IMRT for head-and-neck cancer were retrospectively reviewed under approved IRB protocol. Manually delineated recurrent gross disease (rGTV) on the diagnostic CT documenting recurrence (rCT) was co-registered with the original planning CT (pCT) using both deformable (DIR) and rigid (RIR) image registration software...
2016: Radiation Oncology
Francesco Berardinelli, Piergustavo De Francesco, Michele Marchioni, Nicoletta Cera, Silvia Proietti, Derek Hennessey, Orietta Dalpiaz, Cecilia Cracco, Cesare Scoffone, Luigi Schips, Guido Giusti, Luca Cindolo
PURPOSE: Retrograde intrarenal surgery (RIRS) is considered a safe procedure; however, infective complications are potentially serious postoperative complications. The aim of this multicentre study was to evaluate prospectively the prevalence of infective complications after RIRS and identify risk factors. METHODS: Baseline data were collected, and patients were questioned regarding postoperative infective complications following RIRS. The Fisher exact test, Student t test, Mann-Whitney U test, and multivariate regression analysis were used for data analysis...
November 2016: International Urology and Nephrology
You Jin Lee, Dong Jae Bak, Jae-Wook Chung, Jun Nyung Lee, Hyun Tae Kim, Eun Sang Yoo, Bum Soo Kim
PURPOSE: Based on the experiences of our center, we sought to verify the necessity of actively removing stones during retrograde intrarenal surgery (RIRS) for the management of renal stones. MATERIALS AND METHODS: From March 2010 to March 2015, 248 patients underwent RIRS at our center. We classified these patients into 2 groups according to the performance of active stone removal; group A (n=172) included the patients whose stones were actively removed using a stone basket, and group B (n=76) included the patients whose stones were fragmented with laser lithotripsy without active removal of the fragments...
July 2016: Investigative and Clinical Urology
Wangyao Ge, Nan K Li, Ryan D McCormick, Eli Lichtenberg, Yaroslava G Yingling, Adrienne D Stiff-Roberts
Emulsion-based, resonant infrared matrix-assisted pulsed laser evaporation (RIR-MAPLE) has been demonstrated as an alternative technique to deposit conjugated polymer films for photovoltaic applications; yet, a fundamental understanding of how the emulsion target characteristics translate into film properties and solar cell performance is unclear. Such understanding is crucial to enable the rational improvement of organic solar cell (OSC) efficiency and to realize the expected advantages of emulsion-based RIR-MAPLE for OSC fabrication...
August 3, 2016: ACS Applied Materials & Interfaces
C Ozturk, M I Turan, I S Turan, E Sener, M A Gul
Objective: This was a biochemical and histopathological investigation of the effect of distilled water on oxidative injury induced with ischaemia/reperfusion in rabbit kidneys. Methods: Rabbits were divided into four groups: renal ischaemia (RI), renal ischaemia reperfusion (RIR), renal ischaemia induced and reperfusion initiated with distilled water (RIRW) and a sham operation (SO) group. With the exception of the SO group, ischaemia was induced with a clamp affixed to the renal arteries in all rabbits...
December 9, 2015: West Indian Medical Journal
Makoto Otsuka, Osamu Miyashita, Mitsuru Shibata, Fujiyuki Sato, Mitsuru Naito
Sexing day-old chicks is important for layer and broiler production. A novel method for sexing day-old chicks was developed using an endoscope system. The probe of the endoscope was inserted from the cloaca into the intestine of a chick, and the presence of testes or ovary was observed through the wall of the intestine. The picture image was displayed on the monitor. Sexing was performed in White Leghorn (WL) and Rhode Island Red (RIR) chicks using this new system. The accuracy of sexing was 91.1% in WL chicks and 88...
July 7, 2016: Poultry Science
Esteban Emiliani, Michele Talso, Mohammed Baghdadi, Sadam Ghanem, Jonathan Golmard, Hugo Pinheiro, Agapios Gkentzis, Salvatore Butticè, Olivier Traxer
OBJECTIVE: To describe and discuss the feasibility and the use of apnea during retrograde intrarenal surgery (RIRS). MATERIALS AND METHODS: A discussion of the current literature about the different anesthesia techniques and the use of apnea to improve RIRS by avoiding renal movements over diaphragmatic excursion were performed. RESULTS: To date, there are no mentions in the literature about the use of apnea as a mechanism to facilitate this procedure that requires extremely precise laser use...
June 20, 2016: Urology
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