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https://www.readbyqxmd.com/read/28821613/the-rir-motif-in-the-scaffold-protein-xrcc1-mediates-a-low-affinity-interaction-with-polynucleotide-kinase-phosphatase-pnkp-during-dna-single-strand-break-repair
#1
Claire Breslin, Rajam S Mani, Mesfin Fanta, Nicolas Hoch, Michael Weinfeld, Keith W Caldecott
The scaffold protein X-ray repair cross-complementing 1 (XRCC1) interacts with multiple enzymes involved in DNA base excision repair and single-strand break repair (SSBR) and is important for genetic integrity and normal neurological function. One of the most important interactions of XRCC1 is that with polynucleotide kinase/phosphatase (PNKP), a dual-function DNA kinase/phosphatase that processes damaged DNA termini and that, if mutated, results in ataxia with oculomotor apraxia 4 (AOA4) and microcephaly with early-onset seizures and developmental delay (MCSZ)...
August 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28802643/update-on-urinary-stones-in-children-current-and-future-concepts-in-surgical-treatment-and-shockwave-lithotripsy
#2
REVIEW
Mesrur Selcuk Silay, Jonathan S Ellison, Thomas Tailly, Paolo Caione
CONTEXT: Miniaturized instrumentation used for endoscopic treatment of urinary stone disease in children has been readily adopted in clinical practice. However, there is a need to optimize and individualize the surgical approach according to the patient's age, body habitus, and stone characteristics. Promising novel equipment and techniques will continue to advance the surgical care of these children. OBJECTIVE: To review the literature regarding surgical and shockwave lithotripsy (SWL) treatment of urinary stone disease in children and provide an overview on future treatment innovations...
August 9, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28773061/synthesis-of-nanoscale-cao-al%C3%A2-o%C3%A2-sio%C3%A2-h%C3%A2-o-and-na%C3%A2-o-al%C3%A2-o%C3%A2-sio%C3%A2-h%C3%A2-o-using-the-hydrothermal-method-and-their-characterization
#3
Jingbin Yang, Dongxu Li, Yuan Fang
C-A-S-H (CaO-Al₂O₃-SiO₂-H₂O) and N-A-S-H (Na₂O-Al₂O₃-SiO₂-H₂O) have a wide range of chemical compositions and structures and are difficult to separate from alkali-activated materials. Therefore, it is difficult to analyze their microscopic properties directly. This paper reports research on the synthesis of C-A-S-H and N-A-S-H particles with an average particle size smaller than 300 nm by applying the hydrothermal method. The composition and microstructure of the products with different CaO(Na₂O)/SiO₂ ratios and curing conditions were characterized using XRD, the RIR method, FTIR, SEM, TEM, and laser particle size analysis...
June 26, 2017: Materials
https://www.readbyqxmd.com/read/28766960/the-acceptable-criteria-of-stone-burden-and-the-significant-factors-to-choose-retrograde-intrarenal-stone-surgery-or-miniaturized-percutaneous-nephrolithotomy-for-the-treatment-of-renal-stones-10-mm
#4
Juhyun Park, Sohee Oh, Min Chul Cho, Hwancheol Son, Hyeon Jeong, Chang Wook Jeong, Jong Jin Oh, Sung Yong Cho
Objective We investigated the surgical efficiency and cut-off criteria to determine whether retrograde intrarenal surgery (RIRS) or supine miniaturized percutaneous nephrolithotomy (MPCNL) is appropriate for managing renal stones with a mean size > 10 mm. Materials and Methods Data of a single session RIRS or supine MPCNL was collected in a prospective, observational study. Change point analysis with a cumulative sum of ordered value of fragmentation efficiency and stone size was used to detect the point at which the statistical properties of a sequence of observation changes...
August 2, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28756558/the-old-15%C3%A2-mm-renal-stone-size-limit-for-rirs-remains-a-clinically-significant-threshold-size
#5
Hanan Goldberg, Dor Golomb, Yariv Shtabholtz, Shlomi Tapiero, German Creiderman, Avi Shariv, Jack Baniel, David Lifhshitz
PURPOSE: To investigate the performance of retrograde intrarenal surgery (RIRS) for the 1-2 cm renal stone size range in comparison to smaller stones. MATERIALS AND METHODS: From a data base of 3000 ureteroscopies between 2004 and 2014, 635 consecutive patients underwent RIRS for renal stones. Patients were divided to three groups according to their renal stone size (<10, 10-15, 15-20 mm). Preoperative, operative, stone free rate (SFR) and follow-up data were analyzed and compared...
July 29, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28747484/a-simple-plasma-retinol-isotope-ratio-method-for-estimating-%C3%AE-carotene-relative-bioefficacy-in-humans-validation-with-the-use-of-model-based-compartmental-analysis
#6
Jennifer Lynn Ford, Joanne Balmer Green, Georg Lietz, Anthony Oxley, Michael H Green
Background: Provitamin A carotenoids are an important source of dietary vitamin A for many populations. Thus, accurate and simple methods for estimating carotenoid bioefficacy are needed to evaluate the vitamin A value of test solutions and plant sources. β-Carotene bioefficacy is often estimated from the ratio of the areas under plasma isotope response curves after subjects ingest labeled β-carotene and a labeled retinyl acetate reference dose [isotope reference method (IRM)], but to our knowledge, the method has not yet been evaluated for accuracy...
July 26, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28720366/the-evolving-role-of-retrograde-intrarenal-surgery-in-the-treatment-of-urolithiasis
#7
REVIEW
Francesco Sanguedolce, Giorgio Bozzini, Ben Chew, Panagiotis Kallidonis, Jean de la Rosette
CONTEXT: Retrograde intrarenal surgery has gained substantial popularity worldwide thanks to continuous improvements in technology and techniques, and is now considered one of the first-line treatment options for active removal of renal stones. OBJECTIVE: To provide a comprehensive synthesis of the main evidences in literature on the current management of kidney stones by means of retrograde intrarenal surgery (RIRS). EVIDENCE ACQUISITION: A review of literature has been conducted using search string "retrograde intrarenal surgery OR flexible ureteroscop* OR ureterorenoscop*", without any language restriction; PubMed, Embase, and Scopus databases were searched in November 2016...
February 2017: European Urology Focus
https://www.readbyqxmd.com/read/28717539/single-session-vs-two-sessions-of-flexible-ureterosopy-furs-for-dusting-of-renal-pelvic-stones-2-3-cm-in-diameter-does-stone-size-or-hardness-play-a-role-in-number-of-sessions-to-be-applied
#8
Ahmed Mamdouh Abd El Hamed, Hazem Elmoghazy, Mohamed Aldahshoury, Ahmed Riad, Mohammed Mostafa, Fawzy Farag, Wael Gamal
OBJECTIVE: To evaluate the stone hardness in predicting the need for single or two sessions of retrograde intrarenal surgery (RIRS) for renal pelvis stones of 2-3 cm in size. MATERIAL AND METHODS: Ninety-six patients (64 male and 32 female) with only renal stones (2.5±0.3 cm) underwent RIRS using flexible 7.5 Fr ureteroscope (FURS). The stone hardness was evaluated by preoperative non-contrast computed tomography (NCCT). The patients were divided into two groups based on stone hardness: Group I (n=54) (hard stones - Hounsfield Unit (HU) >1000) and group II (n=42) (not hard stone - HU <1000)...
June 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28717532/retrograde-intrarenal-surgery-for-renal-stones-part-1
#9
REVIEW
Ben Van Cleynenbreugel, Özcan Kılıç, Murat Akand
The main aim in the treatment of renal stones is to clearance of the stones completely with the least morbidity. Parallel to the improvements in technology during recent years, new flexible ureterorenoscopes and effective lithotripters such as holmium laser have been developed, thus retrograde intrarenal surgery (RIRS) has become an efficient and safe option in the management of urinary system stone disease with a gradually increasing popularity. Therewithal, innovations in auxiliary equipment such as guide-wires, ureteral access sheath and stone baskets have made this procedure more effective...
June 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28693386/development-methodology-of-the-novel-endoscopic-stone-treatment-step-1-est-s1-training-assessment-curriculum
#10
Domenico Veneziano, Kamran Ahmed, Ben S E P Van Cleynenbreugel, Ali Serdar Gözen, Joan Palou, Kemal Sarica, Evangelos N Liatsikos, Francesco Sanguedolce, Patrick Honeck, Mario Alvarez-Maestro, Athanasios Papatsoris, Panagiotis Kallidonis, Francesco Greco, Alberto Breda, Bhaskar Somani
Background Simulation based technical-skill assessment is a core topic of debate, especially in high-risk environments. After the introduction of the E-BLUS exam for basic laparoscopy, no more technical training/assessment urological protocols have been developed in Europe. Objective We describe the methodology used in the development of the novel Endoscopic Stone Treatment step 1 (EST s1) assessment curriculum. Materials and Methods The "full life cycle curriculum development" template was followed for curriculum development...
July 10, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28679474/a-comparison-of-micro-perc-and-retrograde-intrarenal-surgery-results-in-pediatric-patients-with-renal-stones
#11
Haluk Sen, Ilker Seckiner, Omer Bayrak, Kazim Dogan, Sakip Erturhan
INTRODUCTION: With advancements in endoscopic surgery, open surgical techniques for urinary system stones have paved the way for the application of less invasive treatment modalities in patients with pediatric kidney stone disease. These treatment options include extracorporeal shock wave lithotripsy (ESWL), percutaneous nephrolithotomy (PCNL), and retrograde intrarenal surgery (RIRS). OBJECTIVE: We aimed to compare the efficacy and safety of RIRS and micro-PCNL techniques in the surgical treatment of kidney stones in pediatric patients...
June 19, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28670667/the-association-of-a-number-of-anatomical-factors-with-the-success-of-retrograde-intrarenal-surgery-in-lower-calyceal-stones
#12
Sercan Sari, Hakki Ugur Ozok, Hikmet Topaloglu, Mehmet Caglar Cakici, Harun Ozdemir, Ahmet Nihat Karakoyunlu, Aykut Bugra Senturk, Hamit Ersoy
PURPOSE: To determine anatomical factors affecting Retrograde Intrarenal Surgery (RIRS) success in the treatment of renal lower calyx stones. MATERIALS AND METHODS: The results of patients were evaluated retrospectively. The patients who have preoperative intravenous urography (IVU) and computed tomography (CT) were divided into two groups as successful (S)(N=103) and unsuccessful(U) (N=29). The anatomic characteristics such as infundibulopelvic angle (IPA), infundibular length (IL), infundibular width (IW) and pelvicaliceal height (PCH) values were compared among two groups...
July 2, 2017: Urology Journal
https://www.readbyqxmd.com/read/28648966/ultra-low-radiation-exposure-during-flexible-ureteroscopy-in-nephrolithiasis-patients-how-far-can-we-go
#13
Simon Hein, Martin Schoenthaler, Konrad Wilhelm, Daniel Schlager, Werner Vach, Ulrich Wetterauer, Arkadiusz Miernik
OBJECTIVES: To evaluate the feasibility and clinical performance of a novel surgeon technique and protocol targeting ultra-low fluoroscopy usage in retrograde intrarenal surgery (RIRS). METHODS: All RIRS procedures between 2009 and 2015 for 10-20-mm renal calculi performed by the same two experienced urologists were eligible. All procedures were performed using a highly standardized step by step RIRS technique. This technique was modified by the ultra-low radiation exposure RIRS protocol: herein as much as possible of the standardized steps were performed without radiation control targeting ultra-low fluoroscopy usage...
June 22, 2017: Urology
https://www.readbyqxmd.com/read/28646216/effects-of-naftopidil-on-double-j-stent-related-discomfort-a-multicenter-randomized-double-blinded-placebo-controlled-study
#14
Jong Jin Oh, Sangchul Lee, Sung Yong Cho, Sang Wook Lee, Min Chul Cho, Woong Na, Ju Hyeon Park, Seung Bae Lee, Soyeon Ahh, Chang Wook Jeong
To evaluate the effect of naftopidil 75 mg once daily for ureteral double-J (DJ) stent-related discomfort after a ureteroscopic procedure using a multicenter, randomized, double-blinded, placebo-controlled study. 100 patients with indwelled retrograde DJ ureteral stents after ureteroscopic stone removal or retrograde intrarenal surgery (RIRS) were randomized 1:1 to receive either placebo or naftopidil during the stenting period. At the time of stent removal, the Ureteral Stent Symptom Questionnaire (USSQ), the International Prostate Symptom Score and the total amount of used analgesics were reported...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28613205/-renal-lithiasis-can-we-predict-the-need-for-retreatment-in-retrograde-intrarenal-surgery-rirs
#15
COMPARATIVE STUDY
José Luis Palmero-Martí, Jorge Panach-Navarrete, Lorena Valls-González, Amparo Ganau-Ituren, Juan Carlos Pastor-Lence, Antonio Benedicto-Redón
OBJECTIVES: To analyze the predictive factors for retreatment in RIRS to achieve complete lithiasis resolution. METHODS: Retrospective comparative study analyzing 298 cases of RIRS performed in our center over a 3 year period. The cohort was divided in two groups: Resolution in one operation or more than one, evaluating homogeneicity for age and gender. We compared the folowing variables: Hounsfield units, body mass index (BMI), number of stones, size, (on the case of multiple stones, larger stone size), side, location in the kidney and stone biochemistry...
June 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28612322/integrative-assessment-of-sediment-quality-in-lower-basin-affected-by-former-mining-in-brazil
#16
Estefanía Bonnail, Lucas M Buruaem, Lucas G Morais, Giuliana S Araujo, Denis M S Abessa, Aguasanta M Sarmiento, T Ángel DelValls
The Ribeira de Iguape River (Southeast Brazil) is metal contaminated by mining activities. Despite it has been cataloged as "in via of restoration" by the literature, this basin is still a sink of pollution in some segments of the fluvial system. This study aimed to assess the sediment quality in the lower part of the RIR basin. The employed approach was based on biological responses of the freshwater clam Corbicula fluminea after 7-day exposure bioassays using as the reference site the Perequê Ecological Park...
June 13, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28608734/endovisually-guided-zero-radiation-ureteral-access-sheath-placement-during-ureterorenoscopy
#17
Seyed Mohammad Kazem Aghamir, Alborz Salavati
BACKGROUND: Almost all endourologic procedures use fluoroscopic imaging in some steps, which exposes both the patient and the surgical team to considerable amounts of radiation. Primary reports on results of a simple direct visual endoscopic access sheath placement technique which does not use fluoroscopy at all are presented. MATERIAL AND METHODS: First a semi-rigid ureteroscopy was carried out up to the renal pelvis, then the access sheath (36 cm, 11/13 Fr) without the obturator was placed over a 7...
June 13, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/28589217/a-prospective-randomized-comparison-of-micropercutaneous-nephrolithotomy-microperc-and-retrograde-intrarenal-surgery-rirs-for-the-management-of-lower-pole-kidney-stones
#18
Abdulkadir Kandemir, Selcuk Guven, Mehmet Balasar, Mehmet Giray Sonmez, Hakan Taskapu, Recai Gurbuz
OBJECTIVE: To make a comparison between the safety and efficacy of micropercutaneous nephrolithotomy (microperc) and retrograde intrarenal surgery (RIRS) for the management of lower pole kidney stones up to 15 mm. PATIENTS AND METHODS: 60 patients presenting with solitary lower pole kidney stones up to 15 mm were included in the study between March 2013 and December 2015. Patients were randomized into Microperc or RIRS groups with computer-generated numbers. RESULTS: The mean stone size was 10...
June 6, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28567327/robot-assisted-laparoscopic-management-of-caliceal-diverticular%C3%A2-calculi
#19
Anneleen Verbrugghe, Loïc Gaillandre, Damien Mouton, Franck Deschildre, Philippe Koenig, Charles Ballereau, Pierre Colin
Standard treatment modalities of caliceal diverticular calculi range from extracorporal shockwave lithotripsy (SWL) over retrograde intrarenal surgery (RIRS), percutaneous nephrolithotomy (PNL) and laparoscopic stone removal. A 55-year-old woman presented with a history of pyelonephritis based on a caliceal diverticular calculus. Due to the narrow infundibulum and anterior location, a robot-assisted laparoscopic calicotomy with extraction of the calculi and fulguration of the diverticulum was performed, with no specific perioperative problems and good stone-free results...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28553645/minimally-invasive-percutaneous-nephrolithotomy-versus-retrograde-intrarenal-surgery-for-upper-urinary-stones-a-systematic-review-and-meta-analysis
#20
REVIEW
Hongyang Jiang, Zhe Yu, Liping Chen, Tao Wang, Zhuo Liu, Jihong Liu, Shaogang Wang, Zhangqun Ye
Minimally invasive percutaneous nephrolithotomy (mini-PCNL) and retrograde intrarenal surgery (RIRS) are both alternatives for PCNL to treat renal calculi. This study is aimed at comparing the stone-free rate (SFR) and other surgery parameters of two approaches for treating upper urinary calculi. We performed this meta-analysis in September 2016 by searching studies about mini-PCNL and RIRS for treating upper urinary calculi in various databases, and RevMan v.5.3 was applied. Three randomized controlled trials and ten nonrandomized trials were included, involving a total of 1317 patients...
2017: BioMed Research International
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