Clément Cuello, Hans J Jansen, Cécile Abdallah, Duchesse-Lacours Zamar Mbadinga, Caroline Birer Williams, Mickael Durand, Audrey Oudin, Nicolas Papon, Nathalie Giglioli-Guivarc'h, Ron P Dirks, Michael Krogh Jensen, Sarah Ellen O'Connor, Sébastien Besseau, Vincent Courdavault
Specialized metabolites possess diverse interesting biological activities and some cardenolides- and monoterpene indole alkaloids- (MIAs) derived pharmaceuticals are currently used to treat human diseases such as cancers or hypertension. While these two families of biocompounds are produced by specific subfamilies of Apocynaceae , one member of this medicinal plant family, the succulent tree Pachypodium lamerei Drake (also known as Madagascar palm), does not produce such specialized metabolites. To explore the evolutionary paths that have led to the emergence and loss of cardenolide and MIA biosynthesis in Apocynaceae , we sequenced and assembled the P...
March 30, 2024: Heliyon