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https://www.readbyqxmd.com/read/28926942/the-semi-synthetic-peptide-lin-sb056-1-in-combination-with-edta-exerts-strong-antimicrobial-and-antibiofilm-activity-against-pseudomonas-aeruginosa-in-conditions-mimicking-cystic-fibrosis-sputum
#1
Giuseppantonio Maisetta, Lucia Grassi, Semih Esin, Ilaria Serra, Mariano A Scorciapino, Andrea C Rinaldi, Giovanna Batoni
Pseudomonas aeruginosa is a major cause of chronic lung infections in cystic fibrosis (CF) patients. The ability of the bacterium to form biofilms and the presence of a thick and stagnant mucus in the airways of CF patients largely contribute to antibiotic therapy failure and demand for new antimicrobial agents able to act in the CF environment. The present study investigated the anti-P. aeruginosa activity of lin-SB056-1, a recently described semi-synthetic antimicrobial peptide, used alone and in combination with the cation chelator ethylenediaminetetraacetic acid (EDTA)...
September 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28926792/u-isotopes-distribution-in-the-lower-rhone-river-and-its-implication-on-radionuclides-disequilibrium-within-the-decay-series
#2
REVIEW
Mathilde Zebracki, Xavier Cagnat, Stéphanie Gairoard, Nicolas Cariou, Frédérique Eyrolle-Boyer, Béatrice Boulet, Christelle Antonelli
The large rivers are main pathways for the delivery of suspended sediments into coastal environments, affecting the biogeochemical fluxes and the ecosystem functioning. The radionuclides from (238)U and (232)Th-series can be used to understand the dynamic processes affecting both catchment soil erosion and sediment delivery to oceans. Based on annual water discharge the Rhone River represents the largest river of the Mediterranean Sea. The Rhone valley also represents the largest concentration in nuclear power plants in Europe...
September 16, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28926608/epibenthic-and-mobile-species-colonisation-of-a-geotextile-artificial-surf-reef-on-the-south-coast-of-england
#3
Roger J H Herbert, Ken Collins, Jenny Mallinson, Alice E Hall, Josephine Pegg, Kathryn Ross, Leo Clarke, Tom Clements
With increasing coastal infrastructure and use of novel materials there is a need to investigate the colonisation of assemblages associated with new structures, how these differ to natural and other artificial habitats and their potential impact on regional biodiversity. The colonisation of Europe's first artificial surf reef (ASR) was investigated at Boscombe on the south coast of England (2009-2014) and compared with assemblages on existing natural and artificial habitats. The ASR consists of geotextile bags filled with sand located 220m offshore on a sandy sea bed at a depth of 0-5m...
2017: PloS One
https://www.readbyqxmd.com/read/28926310/coronary-ct-angiography-derived-fractional-flow-reserve
#4
Christian Tesche, Carlo N De Cecco, Moritz H Albrecht, Taylor M Duguay, Richard R Bayer, Sheldon E Litwin, Daniel H Steinberg, U Joseph Schoepf
Invasive coronary angiography (ICA) with measurement of fractional flow reserve (FFR) by means of a pressure wire technique is the established reference standard for the functional assessment of coronary artery disease (CAD) ( 1 , 2 ). Coronary computed tomographic (CT) angiography has emerged as a noninvasive method for direct assessment of CAD and plaque characterization with high diagnostic accuracy compared with ICA ( 3 , 4 ). However, the solely anatomic assessment provided with both coronary CT angiography and ICA has poor discriminatory power for ischemia-inducing lesions...
October 2017: Radiology
https://www.readbyqxmd.com/read/28926236/biofilms-benefiting-plants-exposed-to-zno-and-cuo-nps-studied-with-a-root-mimetic-hollow-fiber-membrane
#5
Michelle Bonebrake, Kaitlyn C Anderson, Jonathan Valiente, Astrid Rosa Jacobson, Joan E McLean, Anne J Anderson, David W Britt
Plants exist with a consortium of microbes that influence plant health, including response to biotic and abiotic stress. While nanoparticle (NP) - plant interactions are increasingly studied, the effect of NPs on the plant microbiome is less researched. Here a root-mimetic hollow fiber membrane (HFM) is presented for generating biofilms of plant-associated microbes nurtured by artificial root exudates (AREs) to correlate exudate composition with biofilm formation and response to NPs. Two microbial isolates from field-grown wheat, a bacillus endophyte and a pseudomonad root surface colonizer, were examined on HFMs fed with AREs varying in N and C composition...
September 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28926195/non-targeted-volatile-profiles-for-the-classification-of-the-botanical-origin-of-chinese-honey-by-solid-phase-microextraction-and-gc-ms-combined-with-chemometrics
#6
Hui Chen, Linghe Jin, Chunlin Fan, Wenwen Wang
A potential method for the discrimination and prediction of honey samples of various botanical origins was developed based on the non-targeted volatile profiles obtained by solid-phase microextraction with gas chromatography and mass spectrometry combined with chemometrics. The blind analysis of non-targeted volatile profiles was carried out using solid-phase microextraction with gas chromatography and mass spectrometry for 87 authentic honey samples from four botanical origins (acacia, linden, vitex and rape)...
September 19, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28925954/quantitative-structure-activity-relationship-modeling-of-kinase-selectivity-profiles
#7
Sandeepkumar Kothiwale, Corina Borza, Ambra Pozzi, Jens Meiler
The discovery of selective inhibitors of biological target proteins is the primary goal of many drug discovery campaigns. However, this goal has proven elusive, especially for inhibitors targeting the well-conserved orthosteric adenosine triphosphate (ATP) binding pocket of kinase enzymes. The human kinome is large and it is rather difficult to profile early lead compounds against around 500 targets to gain an upfront knowledge on selectivity. Further, selectivity can change drastically during derivatization of an initial lead compound...
September 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28925947/a-dynamic-multi-projection-contour-approximating-framework-for-the-3d-reconstruction-of-buildings-by-super-generalized-optical-stereo-pairs
#8
Yiming Yan, Nan Su, Chunhui Zhao, Liguo Wang
In this paper, a novel framework of the 3D reconstruction of buildings is proposed, focusing on remote sensing super-generalized stereo-pairs (SGSPs). As we all know, 3D reconstruction cannot be well performed using nonstandard stereo pairs, since reliable stereo matching could not be achieved when the image-pairs are collected at a great difference of views, and we always failed to obtain dense 3D points for regions of buildings, and cannot do further 3D shape reconstruction. We defined SGSPs as two or more optical images collected in less constrained views but covering the same buildings...
September 19, 2017: Sensors
https://www.readbyqxmd.com/read/28925817/using-multiple-classifiers-for-predicting-the-risk-of-endovascular-aortic-aneurysm-repair-re-intervention-through-hybrid-feature-selection
#9
Omneya Attallah, Alan Karthikesalingam, Peter Je Holt, Matthew M Thompson, Rob Sayers, Matthew J Bown, Eddie C Choke, Xianghong Ma
Feature selection is essential in medical area; however, its process becomes complicated with the presence of censoring which is the unique character of survival analysis. Most survival feature selection methods are based on Cox's proportional hazard model, though machine learning classifiers are preferred. They are less employed in survival analysis due to censoring which prevents them from directly being used to survival data. Among the few work that employed machine learning classifiers, partial logistic artificial neural network with auto-relevance determination is a well-known method that deals with censoring and perform feature selection for survival data...
September 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28925742/visual-search-performance-in-patients-with-vision-impairment-a-systematic-review
#10
Cassia Senger, Maria Rita Rodrigues Alves Margarido, Carlos Gustavo De Moraes, Ligia Issa De Fendi, André Messias, Jayter Silva Paula
PURPOSE: Patients with visual impairment are constantly facing challenges to achieve an independent and productive life, which depends upon both a good visual discrimination and search capacities. Given that visual search is a critical skill for several daily tasks and could be used as an index of the overall visual function, we investigated the relationship between vision impairment and visual search performance. METHODS: A comprehensive search was undertaken using electronic PubMed, EMBASE, LILACS, and Cochrane databases from January 1980 to December 2016, applying the following terms: "visual search", "visual search performance", "visual impairment", "visual exploration", "visual field", "hemianopia", "search time", "vision lost", "visual loss", and "low vision"...
September 19, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28925381/cavity-qed-with-hybrid-nanocircuits-from-atomic-like-physics-to-condensed-matter-phenomena
#11
Audrey Cottet, Matthieu C Dartiailh, Matthieu M Desjardins, Tino Cubaynes, Lauriane C Contamin, Matthieu Delbecq, Jérémie J Viennot, Laure E Bruhat, Benoit Douçot, Takis Kontos
Circuit QED techniques have been instrumental in manipulating and probing with exquisite sensitivity the quantum state of superconducting quantum bits coupled to microwave cavities. Recently, it has become possible to fabricate new devices in which the superconducting quantum bits are replaced by hybrid mesoscopic circuits combining nanoconductors and metallic reservoirs. This mesoscopic QED provides a new experimental playground to study the light-matter interaction in electronic circuits. Here, we present the experimental state of the art of mesoscopic QED and its theoretical description...
September 19, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28925346/the-effect-of-winter-length-on-duration-of-dormancy-and-survival-of-specialized-herbivorous-rhagoletis-fruit-flies-from-high-elevation-environments-with-acyclic-climatic-variability
#12
J Rull, E Tadeo, R Lasa, M Aluja
Dormancy can be defined as a state of suppressed development allowing insects to cope with adverse conditions and plant phenology. Among specialized herbivorous insects exploiting seasonal resources, diapause frequently evolves as a strategy to adjust to predictable plant seasonal cycles. To cope with acyclic and unpredictable climatic events, it has been found for some insects that a proportion of the population undergoes prolonged dormancy. We compared the response of three species in the Rhagoletis cingulata species group exploiting plants differing in fruiting phenology from environments varying in frequency and timing of acyclic climatic catastrophic events (frost during flowering and fruit set) and varying also in the time of the onset of the rainy season...
September 19, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28925339/improving-the-artificial-diet-for-adult-of-seven-spotted-ladybird-beetle-coccinella-septempunctata-l-coleoptera-coccinellidae-with-orthogonal-design
#13
Y Cheng, J R Zhi, F L Li, W H Li, Y H Zhou
In this study, an orthogonal array design with 16 factors at two levels (216) was performed to develop an artificial diet rearing the adults of seven spotted ladybird beetle Coccinella septempunctata. The parameters of weight gain and survival rate of adults, preoviposition period, fecundity and hatching rate of diet-fed adults were monitored. The 16 factors were included: pork liver, infant formula, sucrose, olive oil, yolk, corn oil, yeast powder, cholesterol, casein, casein hydrolysate, vitamin powder, 65% juvenile hormone III, protein powder, vitamin E, honey and pumpkin...
September 19, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28925099/highly-efficiency-antibacterial-diblock-copolypeptides-based-on-lysine-and-phenylalanine
#14
Xiaokai Su, Xinyu Zhou, Zhengzhong Tan, Chuncai Zhou
A series of amphiphilic diblock copolypeptides (K30 -b-F15 , K30 -b-F30 , and K30 -b-F45 ) were synthesized via N-carboxy-α-amino-anhydride ring-opening polymerization. The copolypeptides had excellent antibacterial efficacy to both Gram positive (S. aureus) and Gram negative (E. coli) bacteria. The minimum inhibitory concentrations (MICs) against E. coli and S. aureus are 8 μg mL(-1) and 2 μg mL(-1) , respectively, lower than most natural and artificial antimicrobial peptides (AMPs). The morphological changes of the bacteria treated with diblock copolypeptides were investigated by transmission electron microscopy; the results proved that the diblock copolypeptides had a similar antibacterial pore-forming mechanism to natural cationic peptides...
September 19, 2017: Biopolymers
https://www.readbyqxmd.com/read/28924568/convolutional-neural-network-for-high-accuracy-functional-near-infrared-spectroscopy-in-a-brain-computer-interface-three-class-classification-of-rest-right-and-left-hand-motor-execution
#15
Thanawin Trakoolwilaiwan, Bahareh Behboodi, Jaeseok Lee, Kyungsoo Kim, Ji-Woong Choi
The aim of this work is to develop an effective brain-computer interface (BCI) method based on functional near-infrared spectroscopy (fNIRS). In order to improve the performance of the BCI system in terms of accuracy, the ability to discriminate features from input signals and proper classification are desired. Previous studies have mainly extracted features from the signal manually, but proper features need to be selected carefully. To avoid performance degradation caused by manual feature selection, we applied convolutional neural networks (CNNs) as the automatic feature extractor and classifier for fNIRS-based BCI...
January 2018: Neurophotonics
https://www.readbyqxmd.com/read/28924506/automated-classification-of-tropical-shrub-species-a-hybrid-of-leaf-shape-and-machine-learning-approach
#16
Miraemiliana Murat, Siow-Wee Chang, Arpah Abu, Hwa Jen Yap, Kien-Thai Yong
Plants play a crucial role in foodstuff, medicine, industry, and environmental protection. The skill of recognising plants is very important in some applications, including conservation of endangered species and rehabilitation of lands after mining activities. However, it is a difficult task to identify plant species because it requires specialized knowledge. Developing an automated classification system for plant species is necessary and valuable since it can help specialists as well as the public in identifying plant species easily...
2017: PeerJ
https://www.readbyqxmd.com/read/28924505/greater-reproductive-investment-but-shorter-lifespan-in-agrosystem-than-in-natural-habitat-toads
#17
Francisco Javier Zamora-Camacho, Mar Comas
Global amphibian decline is due to several factors: habitat loss, anthropization, pollution, emerging diseases, and global warming. Amphibians, with complex life cycles, are particularly susceptible to habitat alterations, and their survival may be impaired in anthropized habitats. Increased mortality is a well-known consequence of anthropization. Life-history theory predicts higher reproductive investment when mortality is increased. In this work, we compared age, body size, and different indicators of reproductive investment, as well as prey availability, in natterjack toads (Epidalea calamita) from agrosystems and adjacent natural pine groves in Southwestern Spain...
2017: PeerJ
https://www.readbyqxmd.com/read/28924210/kinase-inhibitor-screening-using-artificial-neural-networks-and-engineered-cardiac-biowires
#18
Genevieve Conant, Samad Ahadian, Yimu Zhao, Milica Radisic
Kinase inhibitors are often used as cancer targeting agents for their ability to prevent the activation of cell growth and proliferation signals. Cardiotoxic effects have been identified for some marketed kinase inhibitors that were not detected during clinical trials. We hypothesize that more predictive cardiac functional assessments of kinase inhibitors on human myocardium can be established by combining a high-throughput two-dimensional (2D) screening assay and a high-content three-dimensional (3D) engineered cardiac tissue (Biowire(TM)) based assay, and using human induced pluripotent stem cell-derived CMs (hiPSC-CMs)...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28924141/corona-discharge-induced-snow-formation-in-a-cloud-chamber
#19
Jingjing Ju, Tie-Jun Wang, Ruxin Li, Shengzhe Du, Haiyi Sun, Yonghong Liu, Ye Tian, Yafeng Bai, Yaoxiang Liu, Na Chen, Jingwei Wang, Cheng Wang, Jiansheng Liu, S L Chin, Zhizhan Xu
Artificial rainmaking is in strong demand especially in arid regions. Traditional methods of seeding various Cloud Condensation Nuclei (CCN) into the clouds are costly and not environment friendly. Possible solutions based on ionization were proposed more than 100 years ago but there is still a lack of convincing verification or evidence. In this report, we demonstrated for the first time the condensation and precipitation (or snowfall) induced by a corona discharge inside a cloud chamber. Ionic wind was found to have played a more significant role than ions as extra CCN...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923960/igh-isotype-specific-b-cell-receptor-expression-influences-b-cell-fate
#20
Pei Tong, Alessandra Granato, Teng Zuo, Neha Chaudhary, Adam Zuiani, Seung Seok Han, Rakesh Donthula, Akritee Shrestha, Debattama Sen, Jennifer M Magee, Michael P Gallagher, Cees E van der Poel, Michael C Carroll, Duane R Wesemann
Ig heavy chain (IgH) isotypes (e.g., IgM, IgG, and IgE) are generated as secreted/soluble antibodies (sIg) or as membrane-bound (mIg) B cell receptors (BCRs) through alternative RNA splicing. IgH isotype dictates soluble antibody function, but how mIg isotype influences B cell behavior is not well defined. We examined IgH isotype-specific BCR function by analyzing naturally switched B cells from wild-type mice, as well as by engineering polyclonal Ighγ1/γ1 and Ighε/ε mice, which initially produce IgG1 or IgE from their respective native genomic configurations...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
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