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"nutritional therapy" AND chemotherapy

Dalton L Schiessel, Vickie E Baracos
Cancer-associated malnutrition is driven by reduced dietary intake and by underlying metabolic changes (such as inflammation, anabolic resistance, proteolysis, lipolysis and futile cycling) induced by the tumour and activated immune cells. Cytotoxic and targeted chemotherapies also elicit proteolysis and lipolysis at the tissue level. In this review, we summarise specific mediators and chemotherapy effects that provoke excess proteolysis in muscle and excess lipolysis in adipose tissue. A nutritionally relevant question is whether and to what degree these catabolic changes can be reversed by nutritional therapy...
April 30, 2018: Proceedings of the Nutrition Society
Q Zhao, Y Li, B Yu, P G Yang, L Q Fan, B B Tan, Y Tian, A B Yang
Objective: To investigate the effect of postoperative precision nutrition therapy on postoperative recovery (PR) of patients with advanced gastric cancer (AGC) after neoadjuvant chemotherapy (NC). Methods: 71 subjects were randomly divided into 2 groups. The 34 patients of research group were treated with postoperative precision nutrition treatment according to the indirect energy measurement method. The 31 patients of control group were treated with traditional postoperative nutrition treatment. All participants were measured for body mass index (BMI), NRS2002, PG-SGA and relevant laboratory test within the 1st day before surgery and 7th day after surgery...
February 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Wenyan Sun, Yufen Ma, Bing Liu, Ruibing Ge, Kai Wang, Qi Song
Peripherally inserted central catheters (PICCs) have been placed through the peripheral veins, and the best location for the tip of the PICCs is the lower third of the superior vena cava (SVC) and cavo-atrial junction. PICCs are commonly used in intravenous administration, parenteral nutrition therapy, chemotherapy, as well as in critical care units. The success rates in venipuncture are enhanced when ultrasonographic guides are used by the bedside PICC teams. There have been few reports of PICCs placed in super elderly patients with permanent cardiac pacemakers...
January 18, 2017: Journal of Vascular Access
Yueqin Han, Fengzhi Zhang, Jinshen Wang, Yanping Zhu, Jianhua Dai, Yueqing Bu, Qiaozhi Yang, Yingying Xiao, Xiaojing Sun
BACKGROUND: We investigated the effects of glutamine (Gln)-enriched nutritional therapy during chemotherapy on the nutritional status and immune function of children with acute lymphoblastic leukemia (ALL). METHODS: We enrolled 48 children who were newly diagnosed with ALL in our department during the period of 2013.1-2014.12. The patients (follow random number table) were randomly divided into the control group (peptamen) and the treatment group (peptamen + glutamine), 24 cases in each group...
July 11, 2016: Nutrition Journal
Takashi Tsuchiya, Hiroshi Honda, Masaya Oikawa, Tetsuya Kakita, Atsushi Oyama, Hidekazu Oishi, Katsuyuki Tochikubo, Takanao Hashimoto, Shigekazu Kurihara, Tetsuro Shibakusa, Takashi Kayahara
BACKGROUND: Nutritional therapy is used to reduce the adverse events (AEs) of anticancer drugs. Here, we determined whether the amino acids cystine and theanine, which provide substrates for glutathione, attenuated the AEs of S-1 adjuvant chemotherapy. METHODS: Patients scheduled to receive S-1 adjuvant chemotherapy were randomized to the C/T or the control groups. The C/T group received 700 mg cystine and 280 mg theanine orally 1 week before the administration of S-1, which then continued for 5 weeks...
December 2016: International Journal of Clinical Oncology
Xiaoyu Wang, Jiaqi Wang, Zhenghua Wang, Qingjun Wang, Hua Li
OBJECTIVE: The aim of this study was to observe the plasma amino acid and carnitine characteristics in patients with metastatic gastrointestinal malignancies during chemotherapy and to identify markers for the early diagnosis and evaluation of adverse reactions and prognosis of the digestive tract malignant tumor patients. METHODS: Blood samples of 30 patients with metastatic gastrointestinal malignancies were collected at four time points: before chemotherapy, the first day after chemotherapy (+1 day), bone marrow depression period (+14 days), and hematopoietic recovery period (+21 days)...
2015: OncoTargets and Therapy
Ana Luisa Miranda-Vilela, Cesar K Grisolia, João Paulo F Longo, Raphael C A Peixoto, Marcos Célio de Almeida, Lilian Carla P Barbosa, Mariana M Roll, Flávia A Portilho, Luciana L C Estevanato, Anamélia L Bocca, Sônia N Báo, Zulmira G M Lacava
The development of therapeutic strategies to attenuate chemotherapy toxicity represents an area of great interest in cancer research, and among them is nutritional therapy based on antioxidants. As research on this topic is still controversial and scarce, we aim to investigate the effects of antioxidant supplementation with vitamin C, vitamin E or pequi oil, a carotenoid-rich oil extracted from pequi (Caryocar brasiliense), on doxorubicin (DX)-induced oxidative damage to normal cells in Ehrlich solid tumor-bearing mice...
November 2014: Journal of Nutritional Biochemistry
Alessandro Laviano, Serena Rianda, Alessio Molfino, Filippo Rossi Fanelli
PURPOSE OF REVIEW: Significant achievements have been obtained in cancer treatment, but the clinical relevance of drug approach in daily practice remains questionable due to the high costs, limited efficacy, and negligible influence on quality of life. A new concept is emerging which is based on the early combination of chemotherapy and nutrition therapy. RECENT FINDINGS: Inflammation dictates tumour initiation, progression and growth. Omega-3 fatty acids exert anti-inflammatory effects, and therefore recent studies investigated their role in cancer prevention, in cancer cachexia treatment and in enhancement of antitumour therapies...
March 2013: Current Opinion in Clinical Nutrition and Metabolic Care
J R Huddy, F M S Macharg, A M Lawn, S R Preston
Weight loss following esophagectomy is a management challenge for all patients. It is multifactorial with contributing factors including loss of gastric reservoir, rapid small bowel transit, malabsorption, and adjuvant chemotherapy. The development of a postoperative malabsorption syndrome, as a result of exocrine pancreatic insufficiency (EPI), is recognized in a subgroup of patients following gastrectomy. This has not previously been documented following esophageal resection. EPI can result in symptoms of flatulence, diarrhea, steatorrhea, vitamin deficiencies, and weight loss...
August 2013: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Paula Ravasco, Isabel Monteiro-Grillo, Maria Camilo
BACKGROUND: In our published randomized trial in colorectal cancer, group 1 (n = 37) received individualized nutritional counseling and education about regular foods, group 2 (n = 37) received dietary supplements and consumed their usual diet of regular foods, and group 3 (n = 37) consumed their usual diet of regular foods. Neither group 2 nor group 3 received individualized counseling. Early nutritional counseling during radiotherapy was highly effective at reducing acute radiotherapy toxicity and improving nutritional intake/status and quality of life (QoL)...
December 2012: American Journal of Clinical Nutrition
Yasuo Suzuki, Satoshi Motoya, Masakazu Takazoe, Tadashi Kosaka, Masataka Date, Masahiro Nii, Toshifumi Hibi
BACKGROUND AND AIMS: Current treatments for Japanese patients with active Crohn's disease have not proved optimal, and new treatment options are required. The present study therefore evaluated the efficacy and tolerability of oral budesonide in Japanese patients with mild-to-moderate active Crohn's disease. METHODS: In this multicentre, double-blind, randomized, parallel-group, Phase II study, patients (18-65 years) with baseline Crohn's Disease Activity Index (CDAI) score≥200 were randomized to once-daily (od) oral budesonide 9 mg or 15 mg, or matching placebo, for 8 weeks...
April 2013: Journal of Crohn's & Colitis
Nathalie Jacquelin-Ravel, Matti Aapro, Claude Pichard
This review aims to highlight the synergies between clinical nutrition, body composition and cancer treatment. Body composition is already a powerful tool to diagnose cachexia and determine response to nutritionnal intervention. It may be used in the future to fine tune body surface area (BSA) based drug dose determination thanks to its capacity to predict chemotoxicity. The overall aim of nutritionnal intervention is to optimize the oncological care by reducing treatment interruptions and improving the quality of life...
May 23, 2012: Revue Médicale Suisse
Hiroyuki Hanai, Takayuki Iida, Ken Takeuchi, Hajime Arai, Osamu Arai, Jinrou Abe, Tatsuo Tanaka, Yasuhiko Maruyama, Kentarou Ikeya, Ken Sugimoto, Toshio Nakamura, Kouichi Nakamura, Fumitoshi Watanabe
BACKGROUND: 6-Mercaptopurine is often used as maintenance therapy in patients with Crohn's disease. However, toxicities like myelosuppression limit its clinical benefit. AIMS: To evaluate the efficacy of elemental diet versus 6-mercaptopurine as maintenance therapy in Crohn's disease. METHODS: Ninety-five eligible patients with Crohn's disease activity index ≤150 were randomly assigned to: 6-mercaptopurine (0.5-1.5mg/kg/day, n=30); Elental as an elemental diet (≥900 kcal/day, n=32); none (control, n=33)...
August 2012: Digestive and Liver Disease
A Kröner, H Stoll, E Spichiger
Due to the anorexia-cachexia syndrome, cancer patients are already suffering from nutritional problems and weight loss by the time they receive their diagnosis and start chemotherapy. In the oncology outpatient clinic of a Swiss university hospital, patients currently undergo a nutritional assessment and receive individual counselling at the beginning of cancer treatment. This qualitative study explored cancer patients' experiences with weight loss and nutritional problems as well as how they experienced the assessment and the consecutive counselling by nurses...
April 2012: Pflege
Yuka Aimono, Ayako Sakamoto, Masahiko Nemoto, Aya Chikamoto, Yasuyuki Takano, Wataru Sato, Takayuki Sawahata, Masashi Onozaki, Yoshiko Saito, Yoshifumi Aoyama, Noriko Abe, Yuichi Ishikawa, Ako Ito, Tsunehiko Maruyama, Toshiro Kamoshida
OBJECTIVE: We set out to see if nutritional assessment(management)using MUST could be useful for patients undergoing outpatient chemotherapy. METHODS: The study sample consisted of 197 patients undergoing outpatient chemotherapy between June 2010 and November 2010. The results of MUST, serum albumin levels, and nutritional intervention were investigated. RESULTS: High- and medium-risk patients requiring nutritional therapy was comprised of 17/78 breast cancer(21...
January 2012: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Juliana Deh Carvalho Machado, Vivian Marques Miguel Suen, Fernando Bahdur Chueire, Julio Flávio Meirelles Marchini, Julio Sérgio Marchini
Refeeding syndrome (RFS) has been well described but is also a frequently forgotten and undiagnosed complication in clinical practice, which, if untreated, may lead to death. Patients who are more prone to developing RFS are those with at least one of the following conditions: BMI <16 kg/m(2), a recent unintentional weight loss >15%, very little nutritional intake for >10 days, and/or low plasma concentrations of potassium, phosphate or magnesium before feeding; and those with at least two of the following conditions: BMI <18...
2009: BMJ Case Reports
Gregory A Plotnikoff
Interventional nutrition is an emerging field in medicine that utilizes advanced laboratory technologies to identify a patient's clinically relevant biochemical uniqueness in order to treat the metabolic contributors to multifactorial symptoms such as fatigue, insomnia, and pain. This article presents a complex case in which a breast cancer patient's severe symptoms fit no clear disease pattern and prevented her from undergoing chemotherapy and radiation treatment. Specialized testing for metabolic, gastrointestinal, and immunologic function uncovered important nutritional deficiencies that could not be identified through isolated tests or addressed by supplementation with a daily multivitamin...
October 2010: Minnesota Medicine
Yasuhiko Midorikawa, Hiroyuki Nagata, Takeshi Nakati
We provided a home care service to 118 patients from December 1996 to December 2007. One hundred three of 118 patients (87.3%) suffered from malignant disease. We had 90 patients on HPN and 4 patients on HEN using PEG. Home anti-cancer chemotherapy was performed for 29 patients. Most of the patients in our home care suffered from malignant disease, and they were maintained to protein-calorie malnutrition (PCM), so it is important to continue a home care nutrition therapy for survival and QOL advantages. Also, it is important for patient undergoing anti-cancer chemotherapy to maintain a good nutrition for avoiding a complication and to have a continuous chemotherapy...
December 2008: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Lori J Bechard, Henry A Feldman, Catherine Gordon, Kathleen Gura, Andrew Sonis, Kathryn Leung, Robert Venick, Eva C Guinan, Christopher Duggan
BACKGROUND: Children undergoing hematopoietic stem cell transplantation (HSCT) frequently require prolonged courses of parenteral nutrition (PN) as a consequence of gastrointestinal dysfunction related to preparative chemotherapy and radiation. PN has been associated with shorter engraftment time and decreased mortality during HSCT, however, it is also linked with complications, including infections, liver disease, and metabolic disturbances. Some of these complications may be a result of providing PN in excess of nutrient requirements...
March 2010: Contemporary Clinical Trials
Andreea Cranganu, Jayne Camporeale
Lung cancer is the most common type of cancer, excluding nonmelanoma skin cancer, and is the leading cause of cancer death in the United States. Notable carcinogens involved in the development of lung cancer include smoking, secondhand smoke, and radon. Lung cancer is divided into 2 major types: non-small-cell lung cancer, the most prevalent, and small-cell lung cancer. Treatment includes surgery, chemotherapy, radiation, or a combination of the same. Medical nutrition therapy is often required for nutrition-related side effects of cancer treatment, which include but are not limited to anorexia, nausea and vomiting, and esophagitis...
December 2009: Nutrition in Clinical Practice
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