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cervical cancer biomarkers

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https://www.readbyqxmd.com/read/28645254/comparing-self-and-provider-collected-swabbing-for-hpv-dna-testing-in-female-to-male-transgender-adult-patients-a-mixed-methods-biobehavioral-study-protocol
#1
Sari L Reisner, Madeline B Deutsch, Sarah M Peitzmeier, Jaclyn M White Hughto, Timothy Cavanaugh, Dana J Pardee, Sarah McLean, Elliot J Marrow, Matthew J Mimiaga, Lori Panther, Marcy Gelman, Jamison Green, Jennifer Potter
BACKGROUND: Cervical cancer, nearly all cases of which are caused by one of several high-risk strains of the human papillomavirus (hr-HPV), leads to significant morbidity and mortality in individuals with a cervix. Trans masculine (TM) individuals were born with female reproductive organs and identify as male, man, transgender man, or another diverse gender identity different from their female assigned sex at birth. Routine preventive sexual health screening of TM patients is recommended, including screening for cervical cancer and other sexually transmitted infections (STIs); however, as many as one in three TM patients are not up-to-date per recommended U...
June 23, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28644141/prognostic-value-of-hpv-dna-status-in-cervical-cancer-before-treatment-a-systematic-review-and-meta-analysis
#2
Ping Li, Yue Tan, Li-Xia Zhu, Li-Na Zhou, Ping Zeng, Qin Liu, Min-Bin Chen, Ye Tian
BACKGROUND: Human papillomavirus (HPV), has been recognized as an vital preliminary event in the oncogenesis of cervical cancer. But the prognostic value is not well defined, because of past studies showing conflicting results. So we conducted this meta-analysis to evaluate whether HPV DNA status was associated with prognosis in cervical cancer. MATERIALS AND METHODS: A total of 17 previously published eligible studies including 2,838 cases were identified and included in this meta-analysis...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28639905/high-expression-of-kruppel-like-factor-4-as-a-predictor-of-poor-prognosis-for-cervical-cancer-patient-response-to-radiotherapy
#3
Hai-Xia Liu, Na Li, Li Wei, Fu-Xing Zhou, Rui Ma, Feng Xiao, Wei Zhang, Ying Zhang, Yan-Ping Hui, Hui Song, Bi-Liang Chen
PURPOSE: The aim of this study was to explore the associations of Kruppel-like factor 4 expression with sensitivity to radiation therapy in locally advanced cervical squamous cell carcinoma patients. METHODS: The records of 117 locally advanced cervical squamous cell carcinoma patients were retrospectively reviewed, and Kruppel-like factor 4 expression in cervical carcinoma tissues was examined by immunohistochemical staining. The associations of Kruppel-like factor 4 expression with clinicopathological parameters were analyzed...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28621613/relationship-of-il-17a-and-il-17f-genetic-variations-to-cervical-cancer-risk-a-meta-analysis
#4
Shujuan Yang, Chaoying Li, Xuejiao Li, Xiuling Huang, Qingge Zhao, Danping Liu, Siying Wu
AIM: We performed a meta-analysis to determine a more precise relationship of IL-17A and IL-17F polymorphisms with cervical cancer risk. MATERIALS & METHODS: PubMed, CNKI and Wan Fang databases were searched for studies on these associations using STATA version 10.0 software. RESULTS: Five studies were included. The AG and AA genotypes and A allele of IL-17A rs2275913 were correlated with an elevated risk of cervical cancer. The TT genotype and T allele of IL-17A rs3748067 and the CC genotype and C allele of IL-17F rs763780 carried a moderate risk of cervical cancer, when compared with the wild-type genotype...
May 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28617557/expression-of-microrna-142-3p-in-cervical-cancer-and-its-correlation-with-prognosis
#5
M Li, B-Y Li, H Xia, L-L Jiang
OBJECTIVE: The aim of current study was to assess the association between miR-142-3p expression and the prognosis of patients with cervical cancer. PATIENTS AND METHODS: Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to assess the expression level of miR-142-3p in cervical cancer tissues and matched normal tissues. Then, statistical analysis was performed to determine the associations of miR-142-3p expression with the clinical features and the prognosis of cervical cancer...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28615991/mir-34a-and-mir-206-act-as-novel-prognostic-and-therapy-biomarkers-in-cervical-cancer
#6
Ai-Hua Chen, Yu-E Qin, Wen-Fan Tang, Jing Tao, Hua-Mei Song, Manzhen Zuo
BACKGROUND: Recent evidence indicated that the aberrant expression of microRNA plays a crucial role in the development of cervical cancer. The overall shorter survival was strongly related to the abnormal expression of microRNA-34a (miR-34a) and microRNA-206 (miR-206), which target B cell lymphoma-2(Bcl2) and c-Met. Hepatocyte growth factor (HGF)/c-Met pathway is related to the occurrence, development and prognosis of cervical cancer, and c-Met is significantly overexpressed in cervical squamous cell carcinoma...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28607383/isolation-detection-and-quantification-of-cancer-biomarkers-in-hpv-associated-malignancies
#7
Hakan Inan, Shuqi Wang, Fatih Inci, Murat Baday, Richard Zangar, Sailaja Kesiraju, Karen S Anderson, Brian T Cunningham, Utkan Demirci
Human Papillomavirus (HPV) infection has been recognized as the main etiologic factor in the development of various cancers including penile, vulva, oropharyngeal and cervical cancers. In the development of cancer, persistent HPV infections induce E6 and E7 oncoproteins, which promote cell proliferation and carcinogenesis resulting elevated levels of host antibodies (e.g., anti-HPV16 E7 antibody). Currently, these cancers are clinically diagnosed using invasive biopsy-based tests, which are performed only in centralized labs by experienced clinical staff using time-consuming and expensive tools and technologies...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28600545/hotair-rs7958904-polymorphism-is-associated-with-increased-cervical-cancer-risk-in-a-chinese-population
#8
Hua Jin, Xiaoyun Lu, Jing Ni, Jinfang Sun, Bin Gu, Bo Ding, Haixia Zhu, Chao Ma, Mengjing Cui, Yuling Xu, Zhengdong Zhang, Martin Lercher, Jian Chen, Na Gao, Shizhi Wang
Previously, we have identified single nucleotide polymorphisms (SNPs) rs7958904 and rs4759314 in long non-coding RNA HOX transcript antisense RNA (HOTAIR) were significantly associated with risk of colorectal and gastric cancer, respectively. Here, we aimed to investigate the association between HOTAIR SNPs and cervical cancer (CC) susceptibility. A total of 1209 cases and 1348 controls were enrolled for association study and genotyped with TaqMan allelic discrimination method. The Cancer Genome Atlas (TCGA) database was utilized for in vivo analysis of allele-specific HOTAIR expression...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28600296/making-the-case-for-investment-in-rural-cancer-control-an-analysis-of-rural-cancer-incidence-mortality-and-funding-trends
#9
Kelly D Blake, Jennifer L Moss, Anna Gaysynsky, Shobha Srinivasan, Robert T Croyle
Estimates of those living in rural counties vary from 46.2 to 59 million, or 14% to 19% of the U.S. POPULATION: Rural communities face disadvantages compared with urban areas, including higher poverty, lower educational attainment, and lack of access to health services. We aimed to demonstrate rural-urban disparities in cancer and to examine NCI-funded cancer control grants focused on rural populations. Estimates of 5-year cancer incidence and mortality from 2009 to 2013 were generated for counties at each level of the rural-urban continuum and for metropolitan versus nonmetropolitan counties, for all cancers combined and several individual cancer types...
June 9, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28587748/liquid-biopsy-of-pik3ca-mutations-in-cervical-cancer-in-hong-kong-chinese-women
#10
Tony K H Chung, Tak Hong Cheung, So Fan Yim, Mei Yun Yu, Rossa W K Chiu, Keith W K Lo, Ida P C Lee, Raymond R Y Wong, Kitty K M Lau, Vivian W Wang, Michael J Worley, Kevin M Elias, Stephen J Fiascone, David I Smith, Ross S Berkowitz, Yick Fu Wong
INTRODUCTION: Cervical cancer is the fourth most common female cancer worldwide. The prognosis for women with advanced-stage or recurrent cervical cancer remains poor and response to treatment is variable. Standardized management protocols leave little room for individualization. We report on a novel blood-based liquid biopsy for specific PIK3CA mutations as a clinically useful biomarker in patients with invasive cervical cancer. METHODS: One hundred seventeen Hong Kong Chinese women with primary invasive cervical cancer and their pre-treatment plasma samples were investigated...
June 3, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28585749/glycan-profiling-using-formalin-fixed-paraffin-embedded-tissues-hippeastrum-hybrid-lectin-is-a-sensitive-biomarker-for-squamous-cell-carcinoma-of-the-uterine-cervix
#11
Akiko Tozawa-Ono, Manabu Kubota, Chika Honma, Yuko Nakagawa, Noriyuki Yokomichi, Norihito Yoshioka, Chiharu Tsuda, Tatsuru Ohara, Hirotaka Koizumi, Nao Suzuki
AIM: Glycosylation of proteins is altered in cancer cells and distinctive glycan structures are associated with specific cancers, but little is known about the complete glycan profile of particular tumors. In this study, glycomic analysis of squamous cell carcinoma (SCC) of the uterine cervix was performed to search for useful markers. METHODS: A lectin microarray containing 45 lectins with different binding preferences that covered N- and O-linked glycans was coupled with evanescent field-activated fluorescent detection for glycomic analysis of SCC and normal squamous epithelium (NSE) of the cervix...
June 6, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28584715/the-ratio-of-serum-angiopoietin-1-to-angiopoietin-2-in-patients-with-cervical-cancer-is-a-valuable-diagnostic-and-prognostic-biomarker
#12
Ping Yang, Na Chen, Dongyun Yang, Janet Crane, Shouhua Yang, Hangyu Wang, Ruiqing Dong, Xiaoqing Yi, Lisha Xie, Guo Jing, Jing Cai, Zehua Wang
OBJECTIVES: Angiopoietins have been found to play essential roles in tumor angiogenesis. The present study was aimed at investigating the diagnostic and prognostic values of serum angiopoietin 1 and 2 (sAng-1 and sAng-2) in cervical cancer. METHODS: The sAng-1 and sAng-2 concentrations were analyzed in 77 women with cervical cancer, 44 women with cervical intraepithelial neoplasia (CIN) and 43 women without cervical lesions by enzyme-linked immunosorbent assay. The diagnostic values of sAng-1, sAng-2 and sAng-1/sAng-2 were evaluated by receiver operating characteristic (ROC) curves...
2017: PeerJ
https://www.readbyqxmd.com/read/28581408/integration-pattern-of-human-papillomavirus-is-a-strong-prognostic-factor-for-disease-free-survival-after-radiation-therapy-in-cervical-cancer-patients
#13
Jungnam Joo, Hye-Jin Shin, Boram Park, Seog-Yun Park, Chong-Woo Yoo, Kyong-Ah Yoon, Sun-Young Kong, Youn-Jae Kim, Sang Soo Kim, Joo-Young Kim
PURPOSE: The standard chemoradiation therapy currently used for locally advanced cervical cancer (LACC) patients does not reflect the biological heterogeneity of this disease, and there is an increasing need for the development of biomarkers that can help guide the individualized treatment regimens. The purpose of this study was to investigate the prognostic value of the integration pattern of human papillomavirus (HPV) in LACC patients. METHODS AND MATERIALS: The HPV integration pattern was determined by in situ hybridization and polymerase chain reaction, and the tumors were classified as the episomal pattern (group A), as the single-copy integrated or multicopy tandem repetition-integrated pattern (group B), or as undetectable HPV (group C)...
July 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28574830/increased-expression-of-long-non-coding-rna-ccepr-is-associated-with-poor-prognosis-and-promotes-tumorigenesis-in-urothelial-bladder-carcinoma
#14
Yonghao Zhan, Yifan Li, Bao Guan, Xiaoying Chen, Zhicong Chen, Anbang He, Shiming He, Yanqing Gong, Ding Peng, Yuchen Liu, Zhiming Cai, Xuesong Li, Liqun Zhou
Recent emerging evidences have showed that long non-coding RNAs play important regulatory roles in diverse biological processes of tumor development and progression. CCEPR (cervical carcinoma expressed PCNA regulatory lncRNA) is a novel identified lncRNA that acts as a potential biomarker and involves in development and progression of cervical carcinoma. Nevertheless, we know nothing about the clinical significance and molecular mechanism of CCEPR in bladder cancer. In this study, we found that CCEPR was significantly up-regulated in bladder cancer...
May 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28554769/immunohistochemical-expression-of-p16-ki-67-and-p53-in-cervical-lesions-a-systematic-review
#15
REVIEW
Daliana Caldas Silva, Ana Katherine Gonçalves, Ricardo Ney Cobucci, Roberta Cecília Mendonça, Paulo Henrique Lima, Geraldo Cavalcanti
This study evaluated the immunohistochemical (IHC) expression of p16, p53 and Ki-67 in precancerous lesions and in cervical cancer (CC). Identification and review of publications assessing IHC expression in cervical intraepithelial neoplasia (CIN) and CC until February 15, 2017. Systematic review of studies in women with and without cervical lesions in order to evaluate whether there is overexpression of these biomarkers. A total of 28 publications met the criteria which included 6005 patients. The analysis showed that there is higher IHC expression of these biomarkers associated with the more severe lesions...
March 14, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28549791/micrornas-in-gynecological-cancers-small-molecules-with-big-implications
#16
Sanjeev K Srivastava, Aamir Ahmad, Haseeb Zubair, Orlandric Miree, Seema Singh, Rodney P Rocconi, Jennifer Scalici, Ajay P Singh
Gynecological cancers (GCs) are often diagnosed at advanced stages, limiting the efficacy of available therapeutic options. Thus, there remains an urgent and unmet need for innovative research for the efficient clinical management of GC patients. Research over past several years has revealed the enormous promise of miRNAs. These small non-coding RNAs can aid in the diagnosis, prognosis and therapy of all major GCs, viz., ovarian cancers, cervical cancers and endometrial cancers. Mechanistic details of the miRNAs-mediated regulation of multiple biological functions are under constant investigation, and a number of miRNAs are now believed to influence growth, proliferation, invasion, metastasis, chemoresistance and the relapse of different GCs...
May 24, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28534701/plasma-mir-145-as-a-novel-biomarker-for-the-diagnosis-and-radiosensitivity-prediction-of-human-cervical-cancer
#17
Hu Wei, Chen Wen-Ming, Jiao Jun-Bo
Objectives The objective of this study was to evaluate levels of plasma miR-145 in patients with cervical cancer (CC) and investigate its biomarker potential. Methods Using qRT-PCR, we compared plasma miR-145 levels in 120 patients with CC, 120 patients with cervical intraepithelial neoplasia (CIN), and 120 healthy volunteers. The association between plasma miR-145 expression and clinicopathological factors, including radiation response, was also analyzed. Results Plasma miR-145 levels were lower in CC patient than in CIN patients and healthy controls...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28531277/genome-wide-discovery-of-viral-micrornas-based-on-phylogenetic-analysis-and-structural-evolution-of-various-human-papillomavirus-subtypes
#18
Shun-Long Weng, Kai-Yao Huang, Julia Tzu-Ya Weng, Fang-Yu Hung, Tzu-Hao Chang, Tzong-Yi Lee
In mammals, microRNAs (miRNAs) play key roles in controlling posttranscriptional regulation through binding to the mRNAs of target genes. Recently, it was discovered that viral miRNAs may be involved in human cancers and diseases. It is likely that viral miRNAs help viruses enter the latent phase of their life cycle and become undetected by the host's immune system, while increasing the host's risk for cancer development. Cervical cancer is typically related to the infection of human papillomavirus (HPV) through sexual transmission...
May 20, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28515108/a-comparison-of-the-natural-history-of-hpv-infection-and-cervical-abnormalities-among-hiv-positive-and-hiv-negative-women-in-senegal-africa
#19
Hilary K Whitham, Stephen E Hawes, Haitao Chu, J Michael Oakes, Alan R Lifson, Nancy B Kiviat, Papa Salif Sow, Geoffrey S Gottlieb, Selly Ba, Marie P Sy, Shalini L Kulasingam
Background: There is evidence of an interaction between HIV and human papillomavirus (HPV) resulting in increased HPV-associated morbidity and cancer mortality among HIV-positive women. This study aims to determine how the natural history of cervical HPV infection differs by HIV status.Methods: A total of 1,320 women (47% were positive for HIV-1 and/or HIV-2) were followed for an average of two years in Senegal, West Africa between 1994 and 2010. Cytology (with a sub-sample of histology) and HPV DNA testing were performed at approximately 4-month intervals yielding data from over 7,900 clinic visits...
June 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28506076/nos2-as-an-emergent-player-in-progression-of-cancer
#20
Douglas D Thomas, David A Wink
Although the inducible form of nitric oxide synthase (NOS2) was initially shown to be a major player as an antitumor component of the immune response, more recent data have shown that NOS2 expression in cancer cells often predicts poor outcome. Unlike growth factors associated with a single oncogenic pathway, nitric oxide (NO) has a ubiquitous nature wherein it simultaneously mediates major oncogenic pathways from Akt/PI3K and RAS/ERK to HIF1a and TGFb. These interactive loops perpetuate oncogenic mechanism that leads to increased cancer stemness, proliferation metastasis, chemoresistance, angiogenesis, and immunosuppression...
June 10, 2017: Antioxidants & Redox Signaling
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