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cervical cancer biomarkers

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https://www.readbyqxmd.com/read/28534701/plasma-mir-145-as-a-novel-biomarker-for-the-diagnosis-and-radiosensitivity-prediction-of-human-cervical-cancer
#1
Hu Wei, Chen Wen-Ming, Jiao Jun-Bo
Objectives The objective of this study was to evaluate levels of plasma miR-145 in patients with cervical cancer (CC) and investigate its biomarker potential. Methods Using qRT-PCR, we compared plasma miR-145 levels in 120 patients with CC, 120 patients with cervical intraepithelial neoplasia (CIN), and 120 healthy volunteers. The association between plasma miR-145 expression and clinicopathological factors, including radiation response, was also analyzed. Results Plasma miR-145 levels were lower in CC patient than in CIN patients and healthy controls...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28531277/genome-wide-discovery-of-viral-micrornas-based-on-phylogenetic-analysis-and-structural-evolution-of-various-human-papillomavirus-subtypes
#2
Shun-Long Weng, Kai-Yao Huang, Julia Tzu-Ya Weng, Fang-Yu Hung, Tzu-Hao Chang, Tzong-Yi Lee
In mammals, microRNAs (miRNAs) play key roles in controlling posttranscriptional regulation through binding to the mRNAs of target genes. Recently, it was discovered that viral miRNAs may be involved in human cancers and diseases. It is likely that viral miRNAs help viruses enter the latent phase of their life cycle and become undetected by the host's immune system, while increasing the host's risk for cancer development. Cervical cancer is typically related to the infection of human papillomavirus (HPV) through sexual transmission...
May 20, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28515108/a-comparison-of-the-natural-history-of-hpv-infection-and-cervical-abnormalities-among-hiv-positive-and-hiv-negative-women-in-senegal-africa
#3
Hilary K Whitham, Stephen E Hawes, Haitao Chu, J Michael Oakes, Alan R Lifson, Nancy B Kiviat, Papa Salif Sow, Geoffrey S Gottlieb, Selly Ba, Marie P Sy, Shalini L Kulasingam
Background: There is evidence of an interaction between HIV and human papillomavirus (HPV) resulting in increased HPV-associated morbidity and cancer mortality among HIV-positive women. This study aims to determine how the natural history of cervical HPV infection differs by HIV status.Methods: A total of 1,320 women (47% were positive for HIV-1 and/or HIV-2) were followed for an average of two years in Senegal, West Africa between 1994 and 2010. Cytology (with a sub-sample of histology) and HPV DNA testing were performed at approximately 4-month intervals yielding data from over 7,900 clinic visits...
May 17, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28506076/nos2-as-an-emergent-player-in-progression-of-cancer
#4
Douglas D Thomas, David A Wink
Though the inducible form of nitric oxide synthase (NOS2) was initially shown to be a major player as an anti-tumor component of the immune response, more recent data has shown that NOS2 expression in cancer cells often predicts poor outcome. Unlike growth factors associated with a single oncogenic pathway, nitric oxide (NO) has a ubiquitous nature where it simultaneously mediates major oncogenic pathways from Akt/PI3K and RAS/ERK to HIF1a and TGFb. These interactive loops perpetuate oncogenic mechanism that lead to increased cancer stemness, proliferation metastasis, chemoresistance, angiogenesis, and immunosuppression...
May 15, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28492539/non-junctional-cx32-mediates-anti-apoptotic-and-pro-tumor-effects-via-epidermal-growth-factor-receptor-in-human-cervical-cancer-cells
#5
Yifan Zhao, Yongchang Lai, Hui Ge, Yunquan Guo, Xue Feng, Jia Song, Qin Wang, Lixia Fan, Yuexia Peng, Minghui Cao, Andrew L Harris, Xiyan Wang, Liang Tao
The role of connexin proteins (Cx), which form gap junctions (GJ), in progression and chemotherapeutic sensitivity of cervical cancer (CaCx), is unclear. Using cervix specimens (313 CaCx, 78 controls) and CaCx cell lines, we explored relationships among Cx expression, prognostic variables and mechanisms that may link them. In CaCx specimens, Cx32 was upregulated and cytoplasmically localized, and three other Cx downregulated, relative to controls. Cx32 expression correlated with advanced FIGO staging, differentiation and increased tumor size...
May 11, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28486947/diagnostic-and-treatment-modalities-for-patients-with-cervical-lymph-node-metastases-of-unknown-primary-site-current-status-and-challenges
#6
REVIEW
Jens Müller von der Grün, Aykut Tahtali, Shahram Ghanaati, Claus Rödel, Panagiotis Balermpas
BACKGROUND AND PURPOSE: This review aims to provide a comprehensive overview of the literature and elucidate open questions for future clinical trials concerning diagnostics and treatment modalities for cervical cancer of unknown primary (CUP). METHODS: A literature search for head and neck CUP was performed with focus on diagnostics and therapies as well as molecular markers. RESULTS: High level evidence on CUP is limited. However, it seems that a consensus exists regarding the optimal diagnostic procedures...
May 10, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28475243/the-potential-value-of-the-pi3k-akt-mtor-signaling-pathway-for-assessing-prognosis-in-cervical-cancer-and-as-a-target-for-therapy
#7
Afsane Bahrami, Malihe Hasanzadeh, Seyed Mahdi Hassanian, Soodabeh ShahidSales, Majid Ghayour Mobarhan, Gordon A Ferns, Amir Avan
Cervical cancer is a common gynecological cancer and a leading cause of cancer-related death in women globally. There is a need for the identification of prognostic and predictive biomarker for risk stratification. The phosphatidylinositol 3-kinase/ protein kinase B/ mammalian target of rapamycin (PI3K/ Akt/ mTOR) pathway is often dysregulated in cervical cancer, indicating that it may be a potential therapeutic target in the treatment of this malignancy, and could perhaps be used as a novel biomarker in the assessment of risk of developing cervical cancer...
May 5, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28474999/cell-division-cycle-45-promotes-papillary-thyroid-cancer-progression-via-regulating-cell-cycle
#8
Jing Sun, Run Shi, Sha Zhao, Xiaona Li, Shan Lu, Hemei Bu, Xianghua Ma
Cell division cycle 45 was reported to be overexpressed in some cancer-derived cell lines and was predicted to be a candidate oncogene in cervical cancer. However, the clinical and biological significance of cell division cycle 45 in papillary thyroid cancer has never been investigated. We determined the expression level and clinical significance of cell division cycle 45 using The Cancer Genome Atlas, quantitative real-time polymerase chain reaction, and immunohistochemistry. A great upregulation of cell division cycle 45 was observed in papillary thyroid cancer tissues compared with adjacent normal tissues...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28472814/pax1-methylation-as-a-potential-biomarker-to-predict-the-progression-of-cervical-intraepithelial-neoplasia-a-meta-analysis-of-related-studies
#9
Ting Luan, Quan Hua, Xia Liu, Pengfei Xu, Yun Gu, Hua Qian, Lina Yan, Xueqin Xu, Rong Geng, Xin Zeng, Ping Li
OBJECTIVE: The methylation of paired box gene 1 (PAX1) has a great influence on the process of cervical lesion. However, available evidence for the association between PAX1 methylation and cervical intraepithelial neoplasia (CIN) are inconsistent. Here, we systematically reviewed and analyzed PAX1 methylation in progress of CIN. METHODS: Two investigators independently searched eligible studies of PAX1 methylation and CIN that were published in PubMed, Cochrane Library, EMBASE, and Web of Science databases until November 30, 2016...
May 2, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28454353/prmt8-demonstrates-variant-specific-expression-in-cancer-cells-and-correlates-with-patient-survival-in-breast-ovarian-and-gastric-cancer
#10
Sarah J Hernandez, David M Dolivo, Tanja Dominko
Recent emphasis has been placed on the role of epigenetic regulators and epigenetic marks as biomarkers for cancer diagnosis and prognosis, and as therapeutic targets for treatment. One such class of regulators is the protein arginine methyltransferase (PRMT) family. The present study examined available curated data regarding the expression and alteration of one of the least studied PRMT family members, PRMT8, in various types of cancer and cancer cell lines. Publicly available cancer data on PRMT8 expression were examined using the Human Protein Atlas and the Kaplan-Meier Plotter, and reverse transcription-polymerase chain reaction was used to screen a selection of human cell lines for variant-specific PRMT8 expression...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28453530/intracellular-signaling-entropy-can-be-a-biomarker-for-predicting-the-development-of-cervical-intraepithelial-neoplasia
#11
Masakazu Sato, Kei Kawana, Katsuyuki Adachi, Asaha Fujimoto, Mitsuyo Yoshida, Hiroe Nakamura, Haruka Nishida, Tomoko Inoue, Ayumi Taguchi, Juri Ogishima, Satoko Eguchi, Aki Yamashita, Kensuke Tomio, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fujii
While the mortality rates for cervical cancer have been drastically reduced after the introduction of the Pap smear test, it still is one of the leading causes of death in women worldwide. Additionally, studies that appropriately evaluate the risk of developing cervical lesions are needed. Therefore, we investigated whether intracellular signaling entropy, which is measured with microarray data, could be useful for predicting the risks of developing cervical lesions. We used three datasets, GSE63514 (histology), GSE27678 (cytology) and GSE75132 (cytology, a prospective study)...
2017: PloS One
https://www.readbyqxmd.com/read/28448533/determining-the-optimal-number-and-location-of-cutoff-points-with-application-to-data-of-cervical-cancer
#12
Chung Chang, Meng-Ke Hsieh, Wen-Yi Chang, An Jen Chiang, Jiabin Chen
It is often helpful to classify biomarker values into groups of different risk levels to facilitate evaluation of a biological, physiological, or pathological state. Stratification of patients into two risk groups is commonly seen, but there is always need for more than two groups for fine assessment. So far, there are no standard methods or tools to help decide how many cutoff points are optimal. In this study, we developed a comprehensive package that included methods to determine both the optimal number and locations of cutoff points for both survival data and dichotomized outcome...
2017: PloS One
https://www.readbyqxmd.com/read/28443473/proteomic-identification-of-potential-biomarkers-for-cervical-squamous-cell-carcinoma-and-human-papillomavirus-infection
#13
Song Qing, Wuniqiemu Tulake, Mingfang Ru, Xiaohong Li, Reziwanguli Yuemaier, Dilare Lidifu, Aierken Rouzibilali, Axiangu Hasimu, Yun Yang, Reziya Rouziahong, Halmurat Upur, Abulizi Abudula
It is known that high-risk human papillomavirus infection is the main etiological factor in cervical carcinogenesis. However, human papillomavirus screening is not sufficient for early diagnosis. In this study, we aimed to identify potential biomarkers common to cervical carcinoma and human papillomavirus infection by proteomics for human papillomavirus-based early diagnosis and prognosis. To this end, we collected 76 cases of fresh cervical tissues and 116 cases of paraffin-embedded tissue slices, diagnosed as cervical squamous cell carcinoma, cervical intraepithelial neoplasia II-III, or normal cervix from ethnic Uighur and Han women...
April 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28440978/methylation-status-of-p16ink4a-in-human-papillomavirus-associated-cancer-of-oral-cavity-and-oropharynx-in-northeastern-thailand
#14
Piyawut Swangphon, Chamsai Pientong, Ati Burassakarn, Patravoot Vatanasapt, Pilaiwan Kleebkaow, Natcha Patarapadungkit, Thanabut Treebupachatsakul, Supannee Promthet, Bunkerd Kongyingyoes, Tipaya Ekalaksananan
Background: Over-expression of p16INK4a protein is a biomarker for human papillomavirus (HPV)-associated cervical cancer. However, absence of p16INK4a protein expression in HPV-associated cancer of the oral cavity and oropharynx has been reported. Among a number of possible reasons for this is methylation, which is frequently noted in the promoter region of p16INK4a and is associated with silencing of the gene and disease severity. Methods: We investigated the relationships between p16INK4a protein expression, HPV infection and methylation status of the p16INK4a promoter in cancers of the oral cavity and oropharynx...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28430589/ier5-as-a-promising-predictive-marker-promotes-irradiation-induced-apoptosis-in-cervical-cancer-tissues-from-patients-undergoing-chemoradiotherapy
#15
Yang Liu, Ming Tian, Hui Zhao, Yue He, Fengshuang Li, Xiunan Li, Xinping Yu, Kuke Ding, Pingkun Zhou, Yumei Wu
PURPOSE: To define the role of immediate-early 5 (IER5) gene as a promising biomarker in predicting the radiosensitivity and prognosis of cervical cancer patients receiving cisplatin-based concurrent chemoradiotherapy (DDP-CCRT). RESULTS: Our investigations found that IER5 level was markedly elevated in cervical cancer patients after being treated with irradiation, which indicated IER5 was closely dose induced. By contrast, the correlation between IER5 and radiosensitivity cannot be confirmed by the present study...
April 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28405687/gins2-is-a-novel-prognostic-biomarker-and-promotes-tumor-progression-in-early-stage-cervical-cancer
#16
Fei Ouyang, Junling Liu, Meng Xia, Chuyong Lin, Xianqiu Wu, Liping Ye, Libing Song, Jun Li, Jing Wang, Peng Guo, Mian He
GINS complex subunit 2 (GINS2), a member of the GINS complex, is involved in DNA replication. GINS2 is upregulated in a variety of aggressive tumors. However, its role in cervical cancer carcinogenesis remains to be elucidated. We investigated the clinical significance of GINS2 in patients with early-stage cervical cancer and its biological functions in cervical cancer progression. GINS2 expression was analyzed in cervical cancer cell lines and in 8 matched cervical cancer samples at the mRNA and protein levels using real-time PCR and western blotting, respectively...
May 2017: Oncology Reports
https://www.readbyqxmd.com/read/28401338/serum-he4-is-correlated-to-prognostic-factors-and-survival-in-patients-with-endometrial-cancer
#17
A Stiekema, Car Lok, C M Korse, W J van Driel, V van der Noort, G G Kenter, K K Van de Vijver
The extent of surgery and the decision for adjuvant treatment in patients with endometrial cancer (EC) depend on the presence of risk factors for lymph node metastases and disease recurrence. Postoperative markers such as myometrial infiltration and specific mutations can select patients for adjuvant treatment but will not influence surgical planning. A biomarker stratifying patients into low-risk and high-risk groups before surgery could identify patients who benefit from more extensive surgery. Therefore, we evaluated the correlation of serum biomarker HE4 with clinical and recently identified prognostic pathological variables and survival...
April 11, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28393355/reduced-rate-of-human-papillomavirus-infection-and-genetic-overtransmission-of-tp53-72c-polymorphic-variant-lower-cervical-cancer-incidence
#18
Ghazi A Alsbeih, Najla M Al-Harbi, Sara S Bin Judia, Hatim A Khoja, Mohamed M Shoukri, Asma M Tulbah
BACKGROUND: Cervical cancer is a predominantly human papillomavirus (HPV)-driven disease worldwide. However, its incidence is unexplainably low in western Asia, including Saudi Arabia. Using this paradigm, we investigated the role of HPV infection rate and host genetic predisposition in TP53 G72C single nucleotide polymorphism (SNP) presumed to affect cancer incidence. METHODS: Patients treated between 1990 and 2012 were reviewed, and a series of 232 invasive cervical cancer cases were studied and compared with 313 matched controls without cancer...
April 10, 2017: Cancer
https://www.readbyqxmd.com/read/28385388/microrna-138-is-a-potential-biomarker-and-tumor-suppressor-in-human-cervical-carcinoma-by-reversely-correlated-with-tcf3-gene
#19
Huiqin Li, Yang Sheng, Ying Zhang, Nan Gao, Xiangyun Deng, Xiugui Sheng
BACKGROUND: The aim of our work is to identify the functional mechanism of microRNA-138 (miR-138) in human cervical cancer. METHODS: MiR-138 expression was investigated by qRT-PCR in cervical cancer cell lines and human tumors. Correlations of patients' clinicopathological factors and overall survival with miR-138 expression were analyzed. In SiHa and HeLa cells, miR-138 was either upregulated or downregulated to evaluate its regulations on cervical cancer in vitro proliferation, invasion and in vivo xenograft growth...
April 3, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28385383/prognostic-significance-of-gene-amplification-of-actn4-in-stage-i-and-ii-oral-tongue-cancer
#20
T Kakuya, T Mori, S Yoshimoto, Y Watabe, N Miura, H Shoji, K Onidani, T Shibahara, K Honda
Despite complete resection of the early stage of oral tongue cancer by partial glossectomy, late cervical lymph node metastasis is frequently observed. Gene amplification of ACTN4 (protein name: actinin-4) is closely associated with the metastatic potential of various cancers. This retrospective study was performed to demonstrate the potential usefulness of ACTN4 gene amplification as a prognostic biomarker in patients with stage I/II oral tongue cancer. Fifty-four patients with stage I/II oral tongue cancer were enrolled retrospectively, in accordance with the reporting recommendations for tumour marker prognostic studies (REMARK) guidelines...
April 3, 2017: International Journal of Oral and Maxillofacial Surgery
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