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cervical cancer biomarkers

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https://www.readbyqxmd.com/read/29137390/a-cocktail-of-p16-ink4a-and-ki-67-p16-ink4a-and-minichromosome-maintenance-protein-2-as-triage-tests-for-human-papillomavirus-primary-cervical-cancer-screening
#1
Hai-Rui Wang, Yu-Cong Li, Hui-Qin Guo, Lu-Lu Yu, Zeni Wu, Jian Yin, Guang-Dong Liao, Yi-Min Qu, Yu Jiang, Dong Wang, Wen Chen
Most human papillomavirus (HPV) infections are transient and additional triage approaches should be built after HPV-based primary cervical cancer screening. We evaluated the accuracy of p16/Ki-67 and p16/mcm2 dual staining as biomarkers for triaging HPV positive women in China. 4070 participants aged 35 to 64 years attending ongoing cervical cancer screening were enrolled in 2015-2016. Cervical exfoliated cells were collected for HPV DNA analysis and the residual positive specimens were tested for liquid-based cytology and biomarkers...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29131264/upregulation-of-lncrna-pandar-predicts-poor-prognosis-and-promotes-cell-proliferation-in-cervical-cancer
#2
H-W Huang, H Xie, X Ma, F Zhao, Y Gao
OBJECTIVE: To investigate the expression level of long non-coding RNA promoter of CDKN1A antisense DNA damage activated RNA (lncRNA PANDAR) in cervical cancer and to analyze the effects of PANDAR on biological behaviors of cervical cancer and the clinical significance of PANDAR. PATIENTS AND METHODS: A total of 68 pairs of cervical cancer and paired cancer-adjacent tissue specimens were collected. The relative expression of PANDAR in tissues was detected by quantitative Real-time polymerase chain reaction (qRT-PCR) so as to analyze the relationship between PANDAR and clinicopathological factors of cervical cancer and evaluate its clinical significance...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29131134/mannose-binding-lectin-is-not-acting-as-a-biomarker-for-the-progression-of-pre-invasive-lesions-of-invasive-cervical-cancer
#3
Carlos Afonso Maestri, Renato Nisihara, Guilherme P Ramos, Hellen Weinschutz Mendes, Iara Messias-Reason, Newton Sérgio de Carvalho
OBJECTIVE: To evaluate serum concentrations of mannose binding lectin (MBL) in women presenting with different human papilloma virus (HPV)-associated cervical lesions. SUBJECTS AND METHODS: A total of 364 women, who underwent screening for cervical cancer or treatment at Erasto Gaertner Cancer Hospital (HEG), Curitiba, Southern region, Brazil, were enrolled in the study. Based on latest cervical colposcopy-guided biopsy results, the women were divided into four groups: cervical intraepithelial neoplasia (CIN) CIN-I (n=54); CIN-II (n=72); CIN-III (n=145) and invasive cancer (n=93)...
November 7, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29113275/e6-e7-proteins-are-potential-markers-for-the-screening-and-diagnosis-of-cervical-pre-cancerous-lesions-and-cervical-cancer-in-a-chinese-population
#4
Wen-Jing Shi, Hao Liu, Dan Wu, Zhen-Hua Tang, Yu-Chen Shen, Lin Guo
The present prospective study aimed to evaluate the effects of E6/E7 protein detection by western blotting on cervical cancer (CC) early screening compared with detection by Hybrid Capture 2 (HC2) test and ThinPrep cytological test (TCT) in a Chinese population. A total of 450 cases of cervical intraepithelial neoplasia (CIN) suspected samples (positive in ≥1 indicator of TCT and HC2 test) were recruited from women who were treated at the International Peace Maternity and Child Health Hospital (Shanghai, China) from March 2014 to February 2015...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29112685/serum-squamous-cell-carcinoma-antigen-as-an-early-indicator-of-response-during-therapy-of-cervical-cancer
#5
Stephanie Markovina, Songyan Wang, Lauren E Henke, Cliff J Luke, Stephen C Pak, Todd DeWees, John D Pfeifer, Julie K Schwarz, Weijun Liu, Shuai Chen, David Mutch, Xiaowei Wang, Matthew A Powell, Barry A Siegel, Farrokh Dehdashti, Gary A Silverman, Perry W Grigsby
BACKGROUND: Pretreatment serum squamous cell carcinoma antigen (SCCA) is a prognostic biomarker in women with cervical cancer. SCCA has not been evaluated as an early indicator of response to chemoradiation therapy (CRT). The molecular role of the two SCCA isoforms, SCCA1 (SERPINB3) and SCCA2 (SERPINB4), in cervical cancer is unknown. We hypothesised that changes in serum SCCA during definitive CRT predicts treatment response, and that SCCA1 mediates radiation resistance. METHODS: Patients treated with definitive CRT for cervical squamous carcinoma with serum SCCA measured were included...
November 7, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29109779/serum-immune-profiling-for-early-detection-of-cervical-disease
#6
Radwa Ewaisha, Gitika Panicker, Paul Maranian, Elizabeth R Unger, Karen S Anderson
BACKGROUND: The most recent (2012) worldwide estimates from International Agency for Research on Cancer indicate that approximately 528,000 new cases and 270,000 deaths per year are attributed to cervical cancer worldwide. The disease is preventable with HPV vaccination and with early detection and treatment of pre-invasive cervical intraepithelial neoplasia, CIN. Antibodies (Abs) to HPV proteins are under investigation as potential biomarkers for early detection. METHODS: To detect circulating HPV-specific IgG Abs, we developed programmable protein arrays (NAPPA) that display the proteomes of two low-risk HPV types (HPV6 and 11) and ten oncogenic high-risk HPV types (HPV16, 18, 31, 33, 35, 39, 45, 51, 52 and 58)...
2017: Theranostics
https://www.readbyqxmd.com/read/29109451/sim2l-attenuates-resistance-to-hypoxia-and-tumor-growth-by-transcriptional-suppression-of-hif1a-in-uterine-cervical-squamous-cell-carcinoma
#7
Kanako Nakamura, Masayuki Komatsu, Fumiko Chiwaki, Takashi Takeda, Yusuke Kobayashi, Kouji Banno, Daisuke Aoki, Teruhiko Yoshida, Hiroki Sasaki
Despite chemoradiotherapy being one of the most important modalities in advanced cervical cancer, there is a lack of both usable biomarkers to predict treatment outcome and of knowledge about the mechanism of refractoriness to the therapy. Here we identified a transcriptional factor Single-minded homolog 2 (SIM2) as an independent predictive biomarker for uterine cervical squamous cell carcinoma (CvSCC). The retrospective study showed that high expression level of SIM2 was correlated to good survival in CvSCC patients...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29104487/ier5-is-involved-in-dna-double-strand-breaks-repair-in-association-with-papr1-in-hela-cells
#8
Xin-Ping Yu, Yu-Mei Wu, Yang Liu, Ming Tian, Jian-Dong Wang, Ku-Ke Ding, Teng Ma, Ping-Kun Zhou
The immediate early response gene 5 (IER5) is a radiation response gene induced in a dose-independent manner, and has been suggested to be a molecular biomarker for biodosimetry purposes upon radiation exposure. Here, we investigated the function of IER5 in DNA damage response and repair. We found that interference on IER5 expression significantly decreased the efficiency of repair of DNA double-strand breaks induced by ionizing radiations in Hela cells. We found that IER5 participates in the non-homologous end-joining pathway of DNA breaks repair...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29103025/integrated-analysis-reveals-down-regulation-of-sparcl1-is-correlated-with-cervical-cancer-development-and-progression
#9
Dong-Ming Wu, Jiao Shi, Teng Liu, Shi-Hua Deng, Rong Han, Ying Xu
Cervical cancer is the fourth most common malignancy among women worldwide, and continued research to discover biomarkers or therapeutic targets will aid early diagnosis and treatment of this cancer. Here, we investigated novel cervical cancer biomarkers using integrated analysis of high-throughput sequencing data from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. We have identified nine genes of interest that appear to be involved in cervical cancer development: SPARCL1, SYCP2, KIF4A, PRC1, TOP2A, LAMP3, KIF20A, MCM2, and APOBEC3B...
October 19, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29091902/microrna-150-promotes-cell-proliferation-migration-and-invasion-of-cervical-cancer-through-targeting-pdcd4
#10
Zhan Zhang, Jinming Wang, Jing Li, Xiaofang Wang, Wanyu Song
Recent studies have showed that microRNA-150 (miR-150) is up-regulated in various cancers including cervical cancer. However, the specific mechanism of miR-150 in the regulation of cell proliferation, migration and invasion is still unclear. In this study, a total of 150 cervical cancer samples, including 50 cervical cancer tissues, 50 corresponding adjacent non-neoplastic tissues, and 50 serum samples were collected from cervical cancer patients. 50 matched normal tissues and 50 serum samples were collected from the control group...
October 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29089860/high-brain-acid-soluble-protein-1-basp1-is-a-poor-prognostic-factor-for-cervical-cancer-and-promotes-tumor-growth
#11
Huiru Tang, Yan Wang, Bing Zhang, Shiqiu Xiong, Liangshuai Liu, Wei Chen, Guosheng Tan, Heping Li
BACKGROUND: The aim of this study was to determine whether brain abundant membrane attached signal protein 1 (BASP1) is a valuable prognostic biomarker for cervical cancer and whether BASP1 regulates the progression of cervical cancer. METHODS: Quantitative real-time PCR, western blotting, and immunohistochemistry were used to determined BASP1 levels. Statistical analyses were used to examine whether BASP1 was a prognostic factor for patients with cervical cancer...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/29074190/molecular-events-leading-to-hpv-induced-high-grade-neoplasia
#12
REVIEW
Saskia M Wilting, Renske D M Steenbergen
Cervical cancer is initiated by high-risk types of the human papillomavirus (hrHPV) and develops via precursor stages, called cervical intraepithelial neoplasia (CIN). High-grade CIN lesions are considered true precancerous lesions when the viral oncogenes E6 and E7 are aberrantly expressed in the dividing cells. This results in abolishment of normal cell cycle control via p53 and pRb degradation. However, it has become clear that these viral oncogenes possess additional oncogenic properties, including interference with the DNA methylation machinery and mitotic checkpoints...
December 2016: Papillomavirus Research
https://www.readbyqxmd.com/read/29063719/aberrant-single-minded-homolog-1-methylation-as-a-potential-biomarker-for-cervical-cancer
#13
Hyun-Jung Kim, Chan Young Kim, Jinghui Jin, Moon Kyoung Bae, Yun Hee Kim, Woong Ju, Yun Hwan Kim, Seung Cheol Kim
BACKGROUND: The aim of this study is to evaluate the possibility of using the methylation status of single-minded homolog 1 (SIM1) as a diagnostic biomarker for cervical cancer. METHODS: All the patient and normal specimens including the normal cervix (n = 10), cervical cancer tissues (n = 45), blood (n = 45), and cervical brush specimens (n = 110) were retrospectively obtained. Quantitative methylation-specific PCR was performed to detect SIM1 methylation in primary tumors, cervical brush specimens, and plasma circulating cell-free DNA (ccfDNA)...
October 24, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29058790/clinical-and-prognostic-value-of-the-c-met-hgf-signaling-pathway-in-cervical-cancer
#14
REVIEW
Nadia Boromand, Malihe Hasanzadeh, Soodabeh Shahid Sales, Marjaneh Farazestanian, Masoumeh Gharib, Hamid Fiuji, Negin Behboodi, Niloofar Ghobadi, Seyed Mahdi Hassanian, Gordon A Ferns, Amir Avan
Aberrant activation of the HGF/c-Met signalling pathway is reported to be associated with cell proliferation, progression, and metastasis features of several tumor types, including cervical cancer, suggesting that it may be of potential value as a novel therapeutic target. Furthermore, HPV-positive patients had a higher serum level of HGF or c-Met protein, compared with HPV-negative patients. c-Met or HGF overexpression in lesions of cervical cancer is reported to be related to a poorer prognosis, and hence this may be of value as a prognostic and predictive biomarker...
October 23, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29056289/genomic-and-epigenetic-characterization-for-the-comparison-of-synchronous-bilateral-tongue-squamous-cell-carcinomas-a-case-report
#15
Ilda P Ribeiro, Leonor Barroso, Francisco Marques, André Santos, Francisco Caramelo, Maria J Julião, Joana B Melo, Isabel M Carreira
The tongue is the most common and aggressive site for tumors in the oral cavity. These tumors are usually located in the lateral border of the tongue and are often related to the use of tobacco and alcohol. Clinical management of these tumors is predominantly based on anatomic location and TNM classification. The identification of molecular signatures with ability to explain the different outcomes observed in these patients is of paramount importance to guide and help their management. CASE PRESENTATION: we herein describe an 88-year-old woman diagnosed with synchronous bilateral tongue carcinoma...
October 4, 2017: Current Problems in Cancer
https://www.readbyqxmd.com/read/29052373/tissue-multifractality-and-hidden-markov-model-based-integrated-framework-for-optimum-precancer-detection
#16
Sabyasachi Mukhopadhyay, Nandan K Das, Indrajit Kurmi, Asima Pradhan, Nirmalya Ghosh, Prasanta K Panigrahi
We report the application of a hidden Markov model (HMM) on multifractal tissue optical properties derived via the Born approximation-based inverse light scattering method for effective discrimination of precancerous human cervical tissue sites from the normal ones. Two global fractal parameters, generalized Hurst exponent and the corresponding singularity spectrum width, computed by multifractal detrended fluctuation analysis (MFDFA), are used here as potential biomarkers. We develop a methodology that makes use of these multifractal parameters by integrating with different statistical classifiers like the HMM and support vector machine (SVM)...
October 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29051679/multivariate-functional-response-regression-with-application-to-fluorescence-spectroscopy-in-a-cervical-pre-cancer-study
#17
Hongxiao Zhu, Jeffrey S Morris, Fengrong Wei, Dennis D Cox
Many scientific studies measure different types of high-dimensional signals or images from the same subject, producing multivariate functional data. These functional measurements carry different types of information about the scientific process, and a joint analysis that integrates information across them may provide new insights into the underlying mechanism for the phenomenon under study. Motivated by fluorescence spectroscopy data in a cervical pre-cancer study, a multivariate functional response regression model is proposed, which treats multivariate functional observations as responses and a common set of covariates as predictors...
July 2017: Computational Statistics & Data Analysis
https://www.readbyqxmd.com/read/29050779/transcriptome-landscape-of-long-intergenic-non-coding-rnas-in-endometrial-cancer
#18
Bei Jun Chen, Frances L Byrne, Konii Takenaka, Susan C Modesitt, Ellen M Olzomer, James D Mills, Rhonda Farrell, Kyle L Hoehn, Michael Janitz
Endometrial cancer is the most common gynecological malignancy in the developed world. It is the fifth most common cancer and accounts for 4.8% of all cancers in women. Long intergenic non-coding RNAs (lincRNAs), a subclass of long non-coding RNAs, are pervasively transcribed throughout the human genome. OBJECTIVE: LincRNA expression patterns in endometrial cancer compared to normal healthy tissue are poorly characterised. In this study, the lincRNA transcriptome of endometrial cancers and adjacent normal endometrium from the same patients was sequenced and compared with transcriptomes of other gynaecologic malignancies including ovarian and cervical cancers...
October 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29046833/optical-techniques-for-cervical-neoplasia-detection
#19
REVIEW
Tatiana Novikova
This paper provides an overview of the current research in the field of optical techniques for cervical neoplasia detection and covers a wide range of the existing and emerging technologies. Using colposcopy, a visual inspection of the uterine cervix with a colposcope (a binocular microscope with 3- to 15-fold magnification), has proven to be an efficient approach for the detection of invasive cancer. Nevertheless, the development of a reliable and cost-effective technique for the identification of precancerous lesions, confined to the epithelium (cervical intraepithelial neoplasia) still remains a challenging problem...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29034816/clinical-performance-of-loci%C3%A2-based-tumor-marker-assays-for-tumor-markers-ca-15-3-ca-125-cea-ca-19-9-and-afp-in-gynecological-cancers
#20
Ramona C Dolscheid-Pommerich, Mignon Keyver-Paik, Thomas Hecking, Walther Kuhn, Gunther Hartmann, Birgit Stoffel-Wagner, Stefan Holdenrieder
Evidence is sparse regarding the clinical performance of luminescent oxygen channeling immunoassays-based tumor marker assays in gynecological cancer. Analyzing serum samples of 336 patients with Dimension™Vista1500, we investigated the diagnostic power of carbohydrate antigen 15-3, carbohydrate antigen 125, carcinoembryonic antigen, carbohydrate antigen 19-9, and alpha-fetoprotein in patients suffering from different types of gynecological cancer and precancerous gynecological diseases and compared findings to appropriate control groups...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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