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https://www.readbyqxmd.com/read/29344185/downregulation-of-mir-30a-is-associated-with-proliferation-and-invasion-via-targeting-mef2d-in-cervical-cancer
#1
Jing Zhao, Bo Li, Chuqiang Shu, Yun Ma, Yingping Gong
Accumulating studies have revealed that microRNAs serve crucial roles in cancer development and progression. MicroRNA-30a (miR-30a) has been implicated in various cancer types. However, the role of miR-30a in cervical cancer remains unclear. In the current study, a reverse transcription-quantitative polymerase chain reaction (RT-qPCR) assay revealed that miR-30a was significantly downregulated in cervical cancer tissues compared with adjacent normal tissues, and in the cervical cancer cell lines HeLa, SiHa and Ca-Ski compared with GH329 normal cervical epithelial cells...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29338484/the-association-between-micronucleus-nucleoplasmic-bridges-and-nuclear-buds-frequency-and-the-degree-of-uterine-cervical-lesions
#2
Goneta Gashi, Vesna Mahovlić, Suzana Manxhuka-Kerliu, Arjeta Podrimaj-Bytyqi, Luljeta Gashi, Isa R Elezaj
BACKGROUND AND AIM: The loss of genomic stability play an important role in carcinogenesis. Therefore, it is imperative to use certain biomarkers of DNA damage due to genomic instability in order to predict cancer risk. The aim of this study was the evaluation of genomic instability in patients with cervical lesions. MATERIALS AND METHODS: We investigated the genetic damages in 80 subjects: (40) patients with high grade squamous intraepithelial lesions (HSIL), (20) patients with invasive squamous cervical cancer (SCC) and (20) healthy women with a biomarker in two different tissues; the micronucleus (MN) test in peripheral blood lymphocytes (PBL), and in buccal exfoliated cells (BEC)...
January 17, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29333098/mir-22-3p-regulates-cell-proliferation-and-inhibits-cell-apoptosis-through-targeting-the-eif4ebp3-gene-in-human-cervical-squamous-carcinoma-cells
#3
Kang-Tai Lv, Zhu Liu, Jie Feng, Wei Zhao, Tao Hao, Wen-Yan Ding, Jing-Ping Chu, Ling-Juan Gao
Background: MicroRNAs (miRNAs) are non-coding small RNAs that function as negative regulators of gene expression and are involved in tumour biology. The eIF4E-binding proteins (eIF4EBPs) play essential roles in preventing translation initiation and inhibiting protein synthesis at a global or message-specific level in a variety of tumours. Methods: According to comparative miRNA profiles of clinical cervical cancer and non-cancerous cervical tissue specimens, several miRNAs were aberrantly expressed in the cervical cancer samples...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29328485/knockdown-of-hnrnp-a2-b1-inhibits-cell-proliferation-invasion-and-cell-cycle-triggering-apoptosis-in-cervical-cancer-via-pi3k-akt-signaling-pathway
#4
Xiang Shi, Li Ran, Yao Liu, Shu-Huai Zhong, Ping-Ping Zhou, Ming-Xin Liao, Wen Fang
Cervical cancer is currently one of the major threats to women's health. The overexpression of heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) as the biomarker has been investigated in various cancers. In our previous study, we found that lobaplatin induced apoptosis and cell cycle arrest via downregulation of proteins including hnRNP A2/B1 in cervical cancer cells. However, the underlying relationship between hnRNP A2/B1 and cervical cancer remained largely unknown. hnRNP A2/B1 knock‑down in HeLa and CaSki cells was performed by shRNA transfection...
January 5, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29322839/feasibility-study-of-a-human-papillomavirus-e6-and-e7-oncoprotein-test-for-the-diagnosis-of-cervical-precancer-and-cancer
#5
Jin-Jun Zhang, Xin-Chun Cao, Xiang-Yu Zheng, Hai-Ying Wang, Yong-Wei Li
Objective To evaluate the clinical value of human papillomavirus (HPV) E6 and E7 oncoprotein (HPV E6/E7) detection in the early screening of cervical cancer. Methods This prospective study evaluated all patients with suspected cervical intraepithelial neoplasia (CIN) as identified by the presence of at least one positive indicator from a ThinPrep cytologic test (TCT) and/or a Hybrid Capture 2 (HC2) HPV DNA test. The levels of E6/E7 oncoproteins were determined using Western blot analysis. The diagnostic value of the HPV E6/E7 protein assay was compared with the clinical diagnosis from TCT, HC2 and the gold standard of cervical biopsy histology...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29320894/biomarkers-of-tumor-redox-status-in-response-to-modulations-of-glutathione-and-thioredoxin-antioxidant-pathways
#6
Julie Kengen, Jean-Philippe Deglasse, Marie-Aline Neveu, Lionel Mignion, Céline Desmet, Florian Gourgue, Jean-Christophe Jonas, Bernard Gallez, Bénédicte F Jordan
The ability of certain cancer cells to maintain a highly reduced intracellular environment is correlated with aggressiveness and drug resistance. Since the gluthathione (GSH) and thioredoxin (TRX) systems cooperate to a tight regulation of ROS in cell physiology, and to a stimulation of tumor initiation and progression, modulation of the GSH and TRX pathways are emerging as new potential targets in cancer. In vivo methods to assess changes in tumor redox status are critically needed to assess the relevance of redox-targeted agents...
January 10, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29316891/serum-mir-486-5p-as-a-diagnostic-marker-in-cervical-cancer-with-investigation-of-potential-mechanisms
#7
Chunmei Li, Xiaojiao Zheng, Wei Li, Fumao Bai, Jianxin Lyu, Qing H Meng
BACKGROUND: Around the world, cervical cancer is the fourth most common cancer among women. MicroRNAs (miRNAs) and agents that target mRNAs have been introduced as novel diagnostic markers and therapeutic approaches, respectively, in cancer. MiRNA-486-5p is a candidate regulator of phosphatase and tensin homolog (PTEN) in silico, and the downregulation of PTEN in cervical cancer is not consistent with its mutation, which suggests that PTEN may be subjected to post-transcription modification moderated by miRNAs...
January 9, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29313867/hpv-chlamydia-trachomatis-co-infection-metagenomic-analysis-of-cervical-microbiota-in-asymptomatic-women
#8
Marisa Di Pietro, Simone Filardo, Maria Grazia Porpora, Nadia Recine, Maria Agnese Latino, Rosa Sessa
HPV and Chlamydia trachomatis are the most common causes of sexually transmitted diseases worldwide. Most infections are asymptomatic and left untreated lead to severe reproductive tract sequelae such as cervical cancer and infertility. Interestingly, C. trachomatis may also increase the susceptibility to HPV infection as well as contribute to viral persistence. Recently, a growing body of evidence has suggested that the composition of the cervico-vaginal microbiota plays a key role in the susceptibility and outcome of genital infections caused by several pathogens, including HPV and C...
January 9, 2018: New Microbiologica
https://www.readbyqxmd.com/read/29312619/systematic-assessment-of-cervical-cancer-initiation-and-progression-uncovers-genetic-panels-for-deep-learning-based-early-diagnosis-and-proposes-novel-diagnostic-and-prognostic-biomarkers
#9
Nguyen Phuoc Long, Kyung Hee Jung, Sang Jun Yoon, Nguyen Hoang Anh, Tran Diem Nghi, Yun Pyo Kang, Hong Hua Yan, Jung Eun Min, Soon-Sun Hong, Sung Won Kwon
Although many outstanding achievements in the management of cervical cancer (CxCa) have obtained, it still imposes a major burden which has prompted scientists to discover and validate new CxCa biomarkers to improve the diagnostic and prognostic assessment of CxCa. In this study, eight different gene expression data sets containing 202 cancer, 115 cervical intraepithelial neoplasia (CIN), and 105 normal samples were utilized for an integrative systems biology assessment in a multi-stage carcinogenesis manner...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29299913/tracking-hyaluronan-molecularly-imprinted-polymer-coated-carbon-dots-for-cancer-cell-targeting-and-imaging
#10
Bilal Demir, Michael Lemberger, Maria Panagiotopoulou, Paulina Medina-Rangel, Suna Timur, Thomas Hirsch, Bernadette Tse Sum Bui, Joachim Wegener, Karsten Haupt
War against cancer constantly requires new affinity tools to selectively detect, localize and quantify biomarkers for diagnosis or prognosis. Herein, carbon nanodots (CDs), an emerging class of fluorescent nanomaterials, coupled with molecularly imprinted polymers (MIPs), are employed as a biocompatible optical imaging tool for probing cancer biomarkers. First, N-doped CDs were prepared by hydrothermal synthesis using starch as carbon source, and L-tryptophan as nitrogen atom provider to achieve a high quantum yield of (25...
January 4, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29296221/long-noncoding-rna-lncherg-promotes-cell-proliferation-migration-and-invasion-in-glioblastoma
#11
Jian Shi, Yong-Jie Wang, Chong-Ran Sun, Bin Qin, Yang Zhang, Gao Chen
Long noncoding RNAs have recently been proven to regulate tumorgenesis in many cancers. However, their biological functions in glioblastoma remain largely unknown. Here we found an uncharacteristic lncRNA lncHERG that is highly expressed in human glioblastoma (GBM). We found that lncHERG knockdown inhibited cell proliferation, migration and invasion in glioblastoma in vitro and in vivo. Moreover, the higher expression of lncHERG in patients with glioblastoma indicated lower survival rate and poorer prognosis...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29288321/rassf1a-promoter-methylation-was-associated-with-the-development-progression-and-metastasis-of-cervical-carcinoma-a-meta-analysis-with-trial-sequential-analysis
#12
Fei Zheng, Huimin Yu
BACKGROUND: RASSF1A promoter methylation has been reported in cervical cancer. However, clinical effect of RASSF1A promoter methylation in cervical cancer remains unclear. This meta-analysis was conducted to assess the correlation between RASSF1A promoter methylation and cervical cancer and the association of RASSF1A promoter methylation with clinicopathological features. METHODS: Electronic databases were searched to identify eligible publications. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated...
December 29, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29285261/use-of-autoantibodies-against-tumor-associated-antigens-as-serum-biomarkers-for-primary-screening-of-cervical-cancer
#13
Yingji Jin, Seung Cheol Kim, Hyoung Jin Kim, Woong Ju, Yun Hwan Kim, Hong-Jin Kim
Serum autoantibodies against tumor-associated antigens (TAAs) have received much attention as potential biomarkers for early detection of cancers, since they can be detected in the early stages of cancers. Autoantibodies against Cancer Antigen 15-3 (CA15-3), carcinoembryonic antigen (CEA), Cancer Antigen 19-9 (CA19-9), c-Myc, p53, heat shock protein (Hsp)27 and Hsp70 have been suggested as potential markers for detecting several types of cancer. In the present study, the seven types of antibody listed above were evaluated for detecting cervical lesions...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29283433/congems-condensed-gene-co-expression-module-discovery-through-rule-based-clustering-and-its-application-to-carcinogenesis
#14
Saurav Mallik, Zhongming Zhao
For transcriptomic analysis, there are numerous microarray-based genomic data, especially those generated for cancer research. The typical analysis measures the difference between a cancer sample-group and a matched control group for each transcript or gene. Association rule mining is used to discover interesting item sets through rule-based methodology. Thus, it has advantages to find causal effect relationships between the transcripts. In this work, we introduce two new rule-based similarity measures-weighted rank-based Jaccard and Cosine measures-and then propose a novel computational framework to detect condensed gene co-expression modules ( C o n G E M s) through the association rule-based learning system and the weighted similarity scores...
December 28, 2017: Genes
https://www.readbyqxmd.com/read/29279588/comparison-of-the-sensitivity-and-specificity-of-p16-ki-67-dual-staining-and-hpv-dna-testing-of-abnormal-cervical-cytology-in-the-detection-of-histology-proven-cervical-intraepithelial-neoplasia-grade-2-and-above-cin-2
#15
T K Y Tay, K L Lim, M H Hilmy, A A Thike, S T Goh, L H Song, J S G Hwang, S Mantoo
INTRODUCTION: Human papillomavirus (HPV) testing is used as a means of triaging cervico-vaginal smears with low grade squamous abnormalities or as part of co-testing with cytology. While HPV testing has a high sensitivity, it has a low specificity in detecting cervical intraepithelial neoplasia grade 2 and above (CIN 2+) leading to unnecessary colposcopy referrals. We investigate the accuracy of the p16/Ki-67 dual immunocytochemical stain in determining the presence of CIN 2+ lesions on histology and its potential as a superior biomarker for triage...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29243775/independent-prognostic-factor-of-low-expressed-lncrna-znf667-as1-for-cervical-cancer-and-inhibitory-function-on-the-proliferation-of-cervical-cancer
#16
L-P Zhao, R-H Li, D-M Han, X-Q Zhang, G-X Nian, M-X Wu, Y Feng, L Zhang, Z-G Sun
OBJECTIVE: To investigate the expression of long non-coding RNA ZNF667-AS1 in cervical cancer and its effect on the proliferation of cervical cancer cell line, SiHa cells. MATERIALS AND METHODS: The expression level of ZNF667-AS1 from two microarray datasets (GSE63514 and GSE6791) and TCGA (The Cancer Genome Atlas) were selected to analyze the difference between cervical cancer tissues and normal cervical tissues with bioinformatics methods. Then, the prognosis of ZNF667-AS1 was calculated in TCGA...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29229603/lnmicc-promotes-nodal-metastasis-of-cervical-cancer-by-reprogramming-fatty-acid-metabolism
#17
Chunliang Shang, Wei Wang, Yuandong Liao, Yili Chen, Tianyu Liu, Qiqiao Du, Jiaming Huang, Yanchun Liang, Junxiu Liu, Yunhe Zhao, Luyan Guo, Zheng Hu, Shuzhong Yao
Cancer spread to lymph nodes (LN) predicts poor survival but underlying mechanisms remain little understood. In this study, we show that overexpression of the long non-coding RNA LNMICC associates with LN metastasis of primary cervical cancer, where it serves as an independent high-risk factor in patient survival. Functional investigations demonstrated that LNMICC promoted LN metastasis by reprogramming fatty acid metabolism, by recruiting the nuclear factor NPM1 to the promoter of the fatty acid binding protein FABP5...
December 11, 2017: Cancer Research
https://www.readbyqxmd.com/read/29221135/silencing-of-bag3-inhibits-the-epithelial-mesenchymal-transition-in-human-cervical-cancer
#18
Fei Song, Geng Wang, Zhifang Ma, Yuebing Ma, Yingying Wang
Bcl2-associated athanogene 3 (BAG3) has been reported to be involved in aggressive progression of many tumors. In the present study, we examined the expression of BAG3 in human cervical cancer (CC) tissues and investigated the role of BAG3 in SiHa and HeLa cell growth, migration, and invasion. Here, we found that most of CC tissues highly expressed the protein and mRNA of BAG3, while their expression was obviously lower in paired normal tissues (all p<0.001). BAG3 expression was associated with FIGO stage and metastasis (all p<0...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29212506/chromosome-9p-copy-number-gains-involving-pd-l1-are-associated-with-a-specific-proliferation-and-immune-modulating-gene-expression-program-active-across-major-cancer-types
#19
Jan Budczies, Carsten Denkert, Balázs Győrffy, Peter Schirmacher, Albrecht Stenzinger
BACKGROUND: Inhibition of the PD-L1/PD-1 immune checkpoint axis represents one of the most promising approaches of immunotherapy for various cancer types. However, immune checkpoint inhibition is successful only in subpopulations of patients emphasizing the need for powerful biomarkers that adequately reflect the complex interaction between the tumor and the immune system. Recently, recurrent copy number gains (CNG) in chromosome 9p involving PD-L1 were detected in many cancer types including lung cancer, melanoma, bladder cancer, head and neck cancer, cervical cancer, soft tissue sarcoma, prostate cancer, gastric cancer, ovarian cancer, and triple-negative breast cancer...
December 6, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/29212225/the-relevance-of-prelamin-a-and-rad51-as-molecular-biomarkers-in-cervical-cancer
#20
Simona Leonardi, Marianna Buttarelli, Ilaria De Stefano, Gabriella Ferrandina, Marco Petrillo, Gabriele Babini, Giovanni Scambia, Carmela Marino, Mariateresa Mancuso, Daniela Gallo
Along with their role in the maintenance of nuclear architecture, nuclear lamins also control genomic stability, DNA damage repair, transcription, cell proliferation, differentiation and senescence. Recent reports reveal that prelamin A-processing defects play a role in cancer development by impacting on transcription of key players in the maintenance of the genome stability, including RAD51. Here, we performed a 'proof of concept' study evaluating the role of prelamin A and RAD51 expression in clinical outcome of cervical cancer patients...
November 7, 2017: Oncotarget
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