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https://www.readbyqxmd.com/read/28608796/the-natural-history-of-oral-human-papillomavirus-in-young-costa-rican-women
#1
Daniel C Beachler, Krystle A Lang Kuhs, Linda Struijk, John Schussler, Rolando Herrero, Carolina Porras, Allan Hildesheim, Bernal Cortes, Joshua Sampson, Wim Quint, Paula Gonzalez, Aimée R Kreimer
BACKGROUND: Oral human papillomavirus (HPV) infection and related oropharyngeal cancer are uncommon in lower-income countries, particularly compared to HPV-associated cervical cancer. However, little is known about the natural history of oral HPV in less-developed settings and how it compares to the natural history of cervical HPV. METHODS: Three hundred fifty women aged 22 to 33 years from the Costa Rica Vaccine Trial provided exfoliated cells from the cervical and oral regions at 2 visits 2 years apart...
July 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28607581/pembrolizumab-in-cervical-cancer-latest-evidence-and-clinical-usefulness
#2
REVIEW
Edith Borcoman, Christophe Le Tourneau
Cervical cancer is the fourth most common cause of cancer-related deaths in women worldwide. With the development of detection of precancerous lesions and preventive human papillomavirus (HPV) vaccination program, a survival improvement has been observed in these patients in developed countries, although disparities in accessibility to treatments exist across countries. While early-stage cervical cancer can be curable with surgery, prognosis of patients who recur remains poor, with limited treatment options...
June 2017: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/28603909/accuracy-of-combinations-of-visual-inspection-using-acetic-acid-or-lugol-iodine-to-detect-cervical-precancer-a-meta-analysis
#3
Rosa Catarino, Sonja Schäfer, Pierre Vassilakos, Patrick Petignat, Marc Arbyn
BACKGROUND: Visual inspection of the cervix with acetic acid (VIA) or lugol's Iodine (VILI) have been evaluated for cervical cancer screening in developing countries. OBJECTIVES: To assess the diagnostic accuracy and clinical utility of visual methods to detect CIN2+ using: 1) VIA alone, 2) VILI alone, 3) Cotesting, and 4) VILI as triage test of a positive VIA result. SEARCH STRATEGY: PubMed, EMBASE and the Cochrane Library up to May 2016 were searched...
June 12, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28588163/evaluation-of-pelvic-lymphadenectomy-during-radical-hysterectomy-for-cervical-cancer
#4
S Khatun, A Q Huda, S K Begum, J Ferdous
Cervical cancer is the most common cancer in women in developing countries comprising 20-30% of female cancer. More than 70% of cervical cancer patients of Bangladesh attend in hospital in inoperable stages (IIB, III & IV). Only 30% cases can be treated by primary surgery. This prospective cross-sectional study was conducted by Gynaecologic Oncology Division of the Department of Obstetrics & Gynaecology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Bangladesh from November 2011 to May 2012. The objectives of this study were to evaluate the number of pelvic lymph nodes removed, to determine the rate of pelvic lymph node involvement & also to evaluate the relationship between parametrial invasion and pelvic lymph node metastasis...
April 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28577441/exploring-disparities-in-incidence-and-mortality-rates-of-breast-and-gynecologic-cancers-according-to-the-human-development-index-in-the-pan-american-region
#5
J Martínez-Mesa, G Werutsky, S Michiels, C A S Pereira Filho, A Dueñas-González, J J Zarba, M Mano, C Villarreal-Garza, H Gómez, C H Barrios
OBJECTIVE: To evaluate whether a country's Human Development Index (HDI) can help explain the differences in the country's breast cancer and gynecological cancer incidence and mortality rates in the Pan-American region. STUDY DESIGN: Ecological analysis. METHODS: Pan-American region countries with publicly available data both in GLOBOCAN 2012 and the United Nations Development Report 2012 were included (n = 28). Incidence and mortality rates age-standardized per 100,000 were natural log-transformed for breast cancer, ovarian cancer, corpus uteri cancer, and cervical cancer...
June 1, 2017: Public Health
https://www.readbyqxmd.com/read/28545201/treatment-experiences-of-women-with-reproductive-cancers-in-odisha-india-a-qualitative-exploration-of-enablers-and-barriers
#6
Sanghamitra Pati, Abhimanyu Singh Chauhan, Sandeep Mahapatra, Sabita Nayak, Sukdev Nayak, David Weller
Introduction: Cancer continues to be a major menace to our Indian society notwithstanding significant progress in diagnosis and treatment. In India cancer mortality rates in women are high compared to other countries, despite efforts to improve survival through the development of effective detection techniques and increased numbers of viable treatment options. Indian women’s advanced stage of disease at diagnosis is largely attributable to delay in seeking treatment. The present qualitative inquiry was conducted with the aim of capturing the treatment experiences of patients with gynecology cancer at a tertiary care hospital and understanding the barriers, enablers, stress and apprehension they experience during the treatment phases...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28530319/-implementation-of-a-national-screening-program-for-detection-of-malignant-and-pre-malignant-cervical-morbidity-in-israel
#7
REVIEW
Ravit Bassal, Eduardo Schejter, Daniel Cohen, Lital Keinan-Boker
The natural development of cervical cancer, which takes many years, is mostly initiated by infection with human papillomavirus (HPV) and is characterized by the development of precancerous lesions, cervical intraepithelial neoplasia 3 (CIN3), which are defined as abnormal changes in epithelial cells that cover the cervix surface. Since the pre-cancerous process is microscopic and asymptomatic, early detection is based on cytological screening, the Pap test. In Israel, Pap tests are performed based on selfreferral for testing and not within the framework of a national screening program because of the low incidence rate of cervical cancer in Israel...
January 2017: Harefuah
https://www.readbyqxmd.com/read/28515303/spontaneous-and-vaccine-induced-clearance-of-mus-musculus-papillomavirus-type-1-mmupv1-muspv1-infection
#8
Rosie T Jiang, Joshua W Wang, Shiwen Peng, Tsui-Chin Huang, Chenguang Wang, Fabiana Cannella, Yung-Nien Chang, Raphael P Viscidi, Simon R A Best, Chien-Fu Hung, Richard B S Roden
Mus musculus Papillomavirus1 (MmuPV1/MusPV1) induces persistent papillomas in immunodeficient mice but not common laboratory strains. To facilitate study of immune control, we sought an outbred and immune competent laboratory mouse strain in which persistent papillomas could be established. We found that challenge of SKH1 mice (Crl:SKH1-Hrhr) by scarification on their tail with MmuPV1 resulted in three clinical outcomes: 1) persistent (>2 months) papillomas (∼20%), 2) transient papillomas that spontaneously regress typically within 2 months (∼15%), 3) no visible papillomas and viral clearance (∼65%)...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28513340/questions-about-cervical-and-breast-cancer-screening-knowledge-practice-and-outcomes-a-review-of-demographic-and-health-surveys
#9
Laura Viens, Doug Perin, Virginia Senkomago, Antonio Neri, Mona Saraiya
United Nation's Sustainable Development Goals and the World Health Organization's Global Monitoring Framework support a strong global commitment to reducing the high burden of cervical and breast cancers among low- and middle-income countries. Strategies include vaccination, screening, and early diagnosis. Population-based surveys, such as those conducted by the Demographic and Health Surveys (DHS) Program, can collect the information needed to guide cancer control efforts in a standardized comparable manner...
May 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28502577/psycho-social-influences-upon-older-women-s-decision-to-attend-cervical-screening-a-review-of-current-evidence
#10
REVIEW
Kirsty A Hope, Esther Moss, Charles W E Redman, Susan M Sherman
Cervical cancer is the fourth most common cancer in women worldwide (WHO, 2016). In many developed countries the incidence of cervical cancer has been significantly reduced by the introduction of organised screening programmes however, in the UK, a fall in screening coverage is becoming a cause for concern. Much research attention has been afforded to younger women but age stratified mortality and incidence data suggest that older women's screening attendance is also worthy of study. This paper provides a review of current evidence concerning the psycho-social influences that older women experience when deciding whether to attend cervical screening...
May 11, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28469121/the-prevalence-and-course-of-preinvasive-cervical-lesions-during-pregnancy-in-a-northern-nigerian-teaching-hospital
#11
Fadimatu Bakari, Muhammad A Abdul, Saad A Ahmed
BACKGROUND: In spite of knowledge of the causes and prevention of cervical cancer, screening programs for cervical cancer have not yet been fully implemented in most developing countries including Nigeria. Documented data on the prevalence of preinvasive cervical lesion in pregnancy are scarce in our environment. OBJECTIVES: To determine the prevalence, risk factors, and course of preinvasive cervical lesion in pregnant women attending an antenatal clinic in Ahmadu Bello University Teaching Hospital (ABUTH) Zaria, Northern Nigeria Study Design: This was a cross-sectional longitudinal study...
April 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/28464289/cervical-cancer-a-global-health-crisis
#12
REVIEW
William Small, Monica A Bacon, Amishi Bajaj, Linus T Chuang, Brandon J Fisher, Matthew M Harkenrider, Anuja Jhingran, Henry C Kitchener, Linda R Mileshkin, Akila N Viswanathan, David K Gaffney
Cervical cancer is the fourth most common malignancy diagnosed in women worldwide. Nearly all cases of cervical cancer result from infection with the human papillomavirus, and the prevention of cervical cancer includes screening and vaccination. Primary treatment options for patients with cervical cancer may include surgery or a concurrent chemoradiotherapy regimen consisting of cisplatin-based chemotherapy with external beam radiotherapy and brachytherapy. Cervical cancer causes more than one quarter of a million deaths per year as a result of grossly deficient treatments in many developing countries...
May 2, 2017: Cancer
https://www.readbyqxmd.com/read/28440679/cervical-cancer-in-sub-saharan-africa-a-preventable-noncommunicable-disease
#13
Ralph-Sydney Mboumba Bouassa, Thierry Prazuck, Thérèse Lethu, Mohammad-Ali Jenabian, Jean-François Meye, Laurent Bélec
Infections caused by high-risk human papillomavirus (HPV) are responsible for 7.7% of cancers in developing countries, mainly cervical cancer. This disease is steadily increasing in sub-Saharan Africa, with more than 75,000 new cases and 50,000 deaths yearly, further increased by HIV infection. Areas covered: The current status of cervical cancer associated with HPV in sub-Saharan Africa has been systematically revised. The main issues discussed here are related to the public health burden of cervical cancer in sub-Saharan Africa and predictions for the coming decades, including molecular epidemiology and determinants of HPV infection in Africa, and promising prevention measures currently being evaluated in Africa...
May 5, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28438187/prevention-of-cervical-cancer-in-hiv-seropositive-women-from-developing-countries-a-systematic-review-protocol
#14
Witness Mapanga, Ahmed Elhakeem, Shingairai A Feresu, Fresier Maseko, Tsungai Chipato
BACKGROUND: Over 85% of cervical cancer cases and deaths occur in developing countries. HIV-seropositive women are more likely to develop precancerous lesions that lead to cervical cancer than HIV-negative women. However, the literature on cervical cancer prevention in seropositive women in developing countries has not been reviewed. The aim of this study is to systematically review cervical cancer prevention modalities available for HIV-seropositive women in developing countries. METHODS/DESIGN: This protocol was developed by following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement, and the systematic review will be reported in accordance with the PRISMA guidelines...
April 24, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28437708/primary-secondary-and-tertiary-prevention-of-human-papillomavirus-driven-head-and-neck-cancers
#15
REVIEW
Haïtham Mirghani, Alain C Jung, Carole Fakhry
Human papillomavirus (HPV)-driven oropharyngeal cancers (OPCs) represent an increasing proportion of head and neck cancers that could become, in the next few decades, a public health problem in certain western countries. This significant epidemiological change strongly calls for preventive measures. Prophylactic HPV vaccination and screening programmes for early identification and treatment of premalignant lesions are currently being used to reduce the incidence of uterine cervical cancer, which is the paradigm of HPV-driven malignancy...
June 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28414756/reduction-in-the-copy-number-and-expression-level-of-the-recurrent-human-papillomavirus-integration-gene-fragile-histidine-triad-fhit-predicts-the-transition-of-cervical-lesions
#16
Liming Wang, Hui Shen, Bei Feng, Da Zhu, Lan Yu, Xun Tian, Ci Ren, Chun Gao, Xiaomin Li, Ding Ma, Zheng Hu, Hui Wang
Cervical cancer is the second most common cancer and the third leading cause of cancer death in females worldwide, especially in developing countries. High risk human papillomavirus (HR-HPV) infection causes cervical cancer and precancerous cervical intraepithelial neoplasia (CIN). Integration of the HR-HPV genome into the host chromatin is an important step in cervical carcinogenesis. The detection of integrated papillomavirus sequences-PCR (DIPS-PCR) allowed us to explore HPV integration in the human genome and to determine the pattern of this integration...
2017: PloS One
https://www.readbyqxmd.com/read/28406406/cervical-cancer-in-sub-saharan-africa-an-emerging-and-preventable-disease-associated-with-oncogenic-human-papillomavirus
#17
R S Mboumba Bouassa, T Prazuck, T Lethu, J F Meye, L Bélec
Highly oncogenic human papillomavirus (HPV) infections are responsible for 7.7 % of cancers in developing countries, mainly cervical cancer. The incidence of this emerging cancer is steadily increasing in sub-Saharan Africa, with more than 75,000 new cases and close to 50,000 deaths a year, a toll further increased by HIV infection. According to the World Health Organization, cervical cancer will kill more than 443,000 women per year worldwide by 2030, nearly 90 % of them in sub-Saharan Africa. This increase in cervical cancer incidence in Africa is now counteracting the progress made by African women in reducing maternal mortality and increasing longevity...
February 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28403967/organization-and-first-results-of-cervical-cancer-screening-program-in-mayotte-from-2010-to-2014
#18
Z Stewart, E Garcin, A Nazac, C Mezan de Malartic, C Georges, A Cimmino
OBJECTIVES: Our main goal was to report the organization of individual screening for uterus cancer in Mayotte, the last French department since 2011, and its first results. MATERIAL AND METHODS: Epidemiological and observational study describing the prior situation, the beginning of the screening with pap smears in 2010, the colposcopy consultations and the treatment of the patients by the Mayotte network for screening of cancers since 2010. RESULTS: The screening allowed an improvement of the global cover rate from 5% to 24% in 5 years...
February 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28390142/genotypic-diversity-of-anogenital-human-papillomavirus-in-women-attending-cervical-cancer-screening-in-harare-zimbabwe
#19
Racheal S Dube Mandishora, Irene K Christiansen, Nyasha Chin'ombe, Kerina Duri, Bernard Ngara, Trine B Rounge, Roger Meisal, Ole H Ambur, Joel M Palefsky, Babill Stray-Pedersen, Zvavahera M Chirenje
Although anogenital cancers have been on a gradual rise in developing countries in the past few decades, they have been understudied. The objective was to investigate genotypic diversity of anogenital HPV amongst women reporting for routine cervical cancer screening in Harare in Zimbabwe. A cross-sectional study that enrolled 144 women ≥18 years from a cervical cancer-screening clinic was performed. Each woman provided a self-collected cervico-vaginal swab (VS) and a clinician-collected anal swab (CCAS). HIV testing was offered and cervical cytology was performed...
April 8, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28382794/practice-guidelines-for-management-of-cervical-cancer-in-korea-a-korean-society-of-gynecologic-oncology-consensus-statement
#20
REVIEW
Myong Cheol Lim, Maria Lee, Seung Hyuk Shim, Eun Ji Nam, Jung Yun Lee, Hyun Jung Kim, Yoo Young Lee, Kwang Beom Lee, Jeong Yeol Park, Yun Hwan Kim, Kyung Do Ki, Yong Jung Song, Hyun Hoon Chung, Sunghoon Kim, Jeong Won Lee, Jae Weon Kim, Duk Soo Bae, Jong Min Lee
Clinical practice guidelines for gynecologic cancers have been developed by academic society from several countries. Each guideline reflected their own insurance system and unique medical environment, based on the published evidence. The Korean Society of Gynecologic Oncology (KSGO) published the first edition of practice guidelines for gynecologic cancer treatment in late 2006; the second edition was released in July 2010 as an evidence-based recommendation. The Guidelines Revision Committee was established in 2015 and decided to develop the third edition of the guidelines in an advanced format based on evidence-based medicine, embracing up-to-date clinical trials and qualified Korean data...
May 2017: Journal of Gynecologic Oncology
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