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https://www.readbyqxmd.com/read/28530319/-implementation-of-a-national-screening-program-for-detection-of-malignant-and-pre-malignant-cervical-morbidity-in-israel
#1
REVIEW
Ravit Bassal, Eduardo Schejter, Daniel Cohen, Lital Keinan-Boker
The natural development of cervical cancer, which takes many years, is mostly initiated by infection with human papillomavirus (HPV) and is characterized by the development of precancerous lesions, cervical intraepithelial neoplasia 3 (CIN3), which are defined as abnormal changes in epithelial cells that cover the cervix surface. Since the pre-cancerous process is microscopic and asymptomatic, early detection is based on cytological screening, the Pap test. In Israel, Pap tests are performed based on selfreferral for testing and not within the framework of a national screening program because of the low incidence rate of cervical cancer in Israel...
January 2017: Harefuah
https://www.readbyqxmd.com/read/28515303/spontaneous-and-vaccine-induced-clearance-of-mus-musculus-papillomavirus-type-1-mmupv1-muspv1-infection
#2
Rosie T Jiang, Joshua W Wang, Shiwen Peng, Tsui-Chin Huang, Chenguang Wang, Fabiana Cannella, Yung-Nien Chang, Raphael P Viscidi, Simon R A Best, Chien-Fu Hung, Richard B S Roden
Mus musculus Papillomavirus1 (MmuPV1/MusPV1) induces persistent papillomas in immunodeficient mice but not common laboratory strains. To facilitate study of immune control, we sought an outbred and immune competent laboratory mouse strain in which persistent papillomas could be established. We found that challenge of SKH1 mice (Crl:SKH1-Hrhr) by scarification on their tail with MmuPV1 resulted in three clinical outcomes: 1) persistent (>2 months) papillomas (∼20%), 2) transient papillomas that spontaneously regress typically within 2 months (∼15%), 3) no visible papillomas and viral clearance (∼65%)...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28513340/questions-about-cervical-and-breast-cancer-screening-knowledge-practice-and-outcomes-a-review-of-demographic-and-health-surveys
#3
Laura Viens, Doug Perin, Virginia Senkomago, Antonio Neri, Mona Saraiya
United Nation's Sustainable Development Goals and the World Health Organization's Global Monitoring Framework support a strong global commitment to reducing the high burden of cervical and breast cancers among low- and middle-income countries. Strategies include vaccination, screening, and early diagnosis. Population-based surveys, such as those conducted by the Demographic and Health Surveys (DHS) Program, can collect the information needed to guide cancer control efforts in a standardized comparable manner...
May 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28502577/psycho-social-influences-upon-older-women-s-decision-to-attend-cervical-screening-a-review-of-current-evidence
#4
REVIEW
Kirsty A Hope, Esther Moss, Charles W E Redman, Susan M Sherman
Cervical cancer is the fourth most common cancer in women worldwide (WHO, 2016). In many developed countries the incidence of cervical cancer has been significantly reduced by the introduction of organised screening programmes however, in the UK, a fall in screening coverage is becoming a cause for concern. Much research attention has been afforded to younger women but age stratified mortality and incidence data suggest that older women's screening attendance is also worthy of study. This paper provides a review of current evidence concerning the psycho-social influences that older women experience when deciding whether to attend cervical screening...
May 11, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28469121/the-prevalence-and-course-of-preinvasive-cervical-lesions-during-pregnancy-in-a-northern-nigerian-teaching-hospital
#5
Fadimatu Bakari, Muhammad A Abdul, Saad A Ahmed
BACKGROUND: In spite of knowledge of the causes and prevention of cervical cancer, screening programs for cervical cancer have not yet been fully implemented in most developing countries including Nigeria. Documented data on the prevalence of preinvasive cervical lesion in pregnancy are scarce in our environment. OBJECTIVES: To determine the prevalence, risk factors, and course of preinvasive cervical lesion in pregnant women attending an antenatal clinic in Ahmadu Bello University Teaching Hospital (ABUTH) Zaria, Northern Nigeria Study Design: This was a cross-sectional longitudinal study...
April 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/28464289/cervical-cancer-a-global-health-crisis
#6
REVIEW
William Small, Monica A Bacon, Amishi Bajaj, Linus T Chuang, Brandon J Fisher, Matthew M Harkenrider, Anuja Jhingran, Henry C Kitchener, Linda R Mileshkin, Akila N Viswanathan, David K Gaffney
Cervical cancer is the fourth most common malignancy diagnosed in women worldwide. Nearly all cases of cervical cancer result from infection with the human papillomavirus, and the prevention of cervical cancer includes screening and vaccination. Primary treatment options for patients with cervical cancer may include surgery or a concurrent chemoradiotherapy regimen consisting of cisplatin-based chemotherapy with external beam radiotherapy and brachytherapy. Cervical cancer causes more than one quarter of a million deaths per year as a result of grossly deficient treatments in many developing countries...
May 2, 2017: Cancer
https://www.readbyqxmd.com/read/28440679/cervical-cancer-in-sub-saharan-africa-a-preventable-noncommunicable-disease
#7
Ralph-Sydney Mboumba Bouassa, Thierry Prazuck, Thérèse Lethu, Mohammad-Ali Jenabian, Jean-François Meye, Laurent Bélec
Infections caused by high-risk human papillomavirus (HPV) are responsible for 7.7% of cancers in developing countries, mainly cervical cancer. This disease is steadily increasing in sub-Saharan Africa, with more than 75,000 new cases and 50,000 deaths yearly, further increased by HIV infection. Areas covered: The current status of cervical cancer associated with HPV in sub-Saharan Africa has been systematically revised. The main issues discussed here are related to the public health burden of cervical cancer in sub-Saharan Africa and predictions for the coming decades, including molecular epidemiology and determinants of HPV infection in Africa, and promising prevention measures currently being evaluated in Africa...
May 5, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28438187/prevention-of-cervical-cancer-in-hiv-seropositive-women-from-developing-countries-a-systematic-review-protocol
#8
Witness Mapanga, Ahmed Elhakeem, Shingairai A Feresu, Fresier Maseko, Tsungai Chipato
BACKGROUND: Over 85% of cervical cancer cases and deaths occur in developing countries. HIV-seropositive women are more likely to develop precancerous lesions that lead to cervical cancer than HIV-negative women. However, the literature on cervical cancer prevention in seropositive women in developing countries has not been reviewed. The aim of this study is to systematically review cervical cancer prevention modalities available for HIV-seropositive women in developing countries. METHODS/DESIGN: This protocol was developed by following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement, and the systematic review will be reported in accordance with the PRISMA guidelines...
April 24, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28437708/primary-secondary-and-tertiary-prevention-of-human-papillomavirus-driven-head-and-neck-cancers
#9
REVIEW
Haïtham Mirghani, Alain C Jung, Carole Fakhry
Human papillomavirus (HPV)-driven oropharyngeal cancers (OPCs) represent an increasing proportion of head and neck cancers that could become, in the next few decades, a public health problem in certain western countries. This significant epidemiological change strongly calls for preventive measures. Prophylactic HPV vaccination and screening programmes for early identification and treatment of premalignant lesions are currently being used to reduce the incidence of uterine cervical cancer, which is the paradigm of HPV-driven malignancy...
April 19, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28414756/reduction-in-the-copy-number-and-expression-level-of-the-recurrent-human-papillomavirus-integration-gene-fragile-histidine-triad-fhit-predicts-the-transition-of-cervical-lesions
#10
Liming Wang, Hui Shen, Bei Feng, Da Zhu, Lan Yu, Xun Tian, Ci Ren, Chun Gao, Xiaomin Li, Ding Ma, Zheng Hu, Hui Wang
Cervical cancer is the second most common cancer and the third leading cause of cancer death in females worldwide, especially in developing countries. High risk human papillomavirus (HR-HPV) infection causes cervical cancer and precancerous cervical intraepithelial neoplasia (CIN). Integration of the HR-HPV genome into the host chromatin is an important step in cervical carcinogenesis. The detection of integrated papillomavirus sequences-PCR (DIPS-PCR) allowed us to explore HPV integration in the human genome and to determine the pattern of this integration...
2017: PloS One
https://www.readbyqxmd.com/read/28406406/cervical-cancer-in-sub-saharan-africa-an-emerging-and-preventable-disease-associated-with-oncogenic-human-papillomavirus
#11
R S Mboumba Bouassa, T Prazuck, T Lethu, J F Meye, L Bélec
Highly oncogenic human papillomavirus (HPV) infections are responsible for 7.7 % of cancers in developing countries, mainly cervical cancer. The incidence of this emerging cancer is steadily increasing in sub-Saharan Africa, with more than 75,000 new cases and close to 50,000 deaths a year, a toll further increased by HIV infection. According to the World Health Organization, cervical cancer will kill more than 443,000 women per year worldwide by 2030, nearly 90 % of them in sub-Saharan Africa. This increase in cervical cancer incidence in Africa is now counteracting the progress made by African women in reducing maternal mortality and increasing longevity...
February 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28403967/organization-and-first-results-of-cervical-cancer-screening-program-in-mayotte-from-2010-to-2014
#12
Z Stewart, E Garcin, A Nazac, C Mezan de Malartic, C Georges, A Cimmino
OBJECTIVES: Our main goal was to report the organization of individual screening for uterus cancer in Mayotte, the last French department since 2011, and its first results. MATERIAL AND METHODS: Epidemiological and observational study describing the prior situation, the beginning of the screening with pap smears in 2010, the colposcopy consultations and the treatment of the patients by the Mayotte network for screening of cancers since 2010. RESULTS: The screening allowed an improvement of the global cover rate from 5% to 24% in 5 years...
February 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28390142/genotypic-diversity-of-anogenital-human-papillomavirus-in-women-attending-cervical-cancer-screening-in-harare-zimbabwe
#13
Racheal S Dube Mandishora, Irene Kraus Christiansen, Nyasha Chin'ombe, Kerina Duri, Bernard Ngara, Trine B Rounge, Roger Meisal, Ole Herman Ambur, Joel M Palefsky, Babill Stray-Pedersen, Zvavahera M Chirenje
BACKGROUND: Although anogenital cancers have been on a gradual rise in developing countries in the past few decades, they have been understudied. OBJECTIVE: To investigate genotypic diversity of anogenital HPV amongst women reporting for routine cervical cancer screening in Harare in Zimbabwe. METHODS: A cross sectional study that enrolled 144 women ≥18 years from a cervical cancer-screening clinic was performed. Each woman provided a self-collected cervico-vaginal swab (VS) and a clinician collected anal swab (CCAS)...
April 8, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28382794/practice-guidelines-for-management-of-cervical-cancer-in-korea-a-korean-society-of-gynecologic-oncology-consensus-statement
#14
REVIEW
Myong Cheol Lim, Maria Lee, Seung Hyuk Shim, Eun Ji Nam, Jung Yun Lee, Hyun Jung Kim, Yoo Young Lee, Kwang Beom Lee, Jeong Yeol Park, Yun Hwan Kim, Kyung Do Ki, Yong Jung Song, Hyun Hoon Chung, Sunghoon Kim, Jeong Won Lee, Jae Weon Kim, Duk Soo Bae, Jong Min Lee
Clinical practice guidelines for gynecologic cancers have been developed by academic society from several countries. Each guideline reflected their own insurance system and unique medical environment, based on the published evidence. The Korean Society of Gynecologic Oncology (KSGO) published the first edition of practice guidelines for gynecologic cancer treatment in late 2006; the second edition was released in July 2010 as an evidence-based recommendation. The Guidelines Revision Committee was established in 2015 and decided to develop the third edition of the guidelines in an advanced format based on evidence-based medicine, embracing up-to-date clinical trials and qualified Korean data...
May 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28374230/evaluation-of-entertainment-education-strategies-to-promote-cervical-cancer-screening-and-knowledge-in-colombian-women
#15
Roland Lincoln Boyden Lamb, Sara Milena Ramos Jaraba, Valentina Graciano Tangarife, Isabel C Garcés-Palacio
Cervical cancer is considered to be a major health problem for women in developing countries, but it is also problematic for more developed countries as global migration increases and health behaviors move from the countries of origin to new places of residence. We designed and produced a testimonial video and a fotonovela (printed short story) to educate women about cervical cancer and screening. The development of the materials included formative research, production, pretesting, dissemination, and evaluation...
April 4, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28369882/worldwide-burden-of-cancer-attributable-to-hpv-by-site-country-and-hpv-type
#16
Catherine de Martel, Martyn Plummer, Jerome Vignat, Silvia Franceschi
HPV is the cause of almost all cervical cancer and is responsible for a substantial fraction of other anogenital cancer and oropharyngeal cancer. Understanding the HPV-attributable cancer burden can boost programs of HPV vaccination and HPV-based cervical screening. Attributable fractions (AF) and the relative contributions of different HPV types were derived from published studies reporting on the prevalence of transforming HPV infection in cancer tissue. Maps of age-standardized incidence rates of HPV-attributable cancers by country from GLOBOCAN 2012 data are shown separately for the cervix, other anogenital tract, and head and neck cancers...
April 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28355089/ct-vaginography-a-new-ct-technique-for-imaging-of-upper-and-middle-vaginal-fistulas
#17
Diomidis Botsikas, Nicola Pluchino, Anastasia Kalovidouri, Alexandra Platon, Xavier Montet, Patrick Dallenbach, Pierre-Alexandre Poletti
OBJECTIVE: Different types of vaginal fistulas is a relatively uncommon condition in the Western world but very frequent in developing countries. In the past, conventional vaginography was the radiological examination of choice for exploring this condition. CT and MRI are now both used for this purpose. Our objective was to test the feasibility and to explore the potential role of a new CT imaging technique implementing vaginal introitus obstruction and opacification of the vagina with iodine contrast agent, to show patency of a fistula...
May 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28351879/a-non-gas-based-cryotherapy-system-for-the-treatment-of-cervical-intraepithelial-neoplasia-a-mixed-methods-approach-for-initial-development-and-testing
#18
Miriam Cremer, Proma Paul, Katie Bergman, Michael Haas, Mauricio Maza, Albert Zevallos, Miguel Ossandon, Jillian D Garai, Jennifer L Winkler
BACKGROUND: Gas-based cryotherapy is the most widely used treatment strategy for cervical intraepithelial neoplasia (CIN) in low-resource settings, but reliance on gas presents challenges in low- and middle-income countries (LMICs). Our team adapted the original CryoPen Cryosurgical System, a cryotherapy device that does not require compressed gas and is powered by electricity, for use in LMICs. METHODS: A mixed-methods approach was used involving both qualitative and quantitative methods...
March 24, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28346680/human-papillomavirus-in-cervical-cancer-and-oropharyngeal-cancer-one-cause-two-diseases
#19
REVIEW
Tara A Berman, John T Schiller
Human papillomavirus (HPV) causes greater than 5% of cancers worldwide, including all cervical cancers and an alarmingly increasing proportion of oropharyngeal cancers (OPCs). Despite markedly reduced cervical cancer incidence in industrialized nations with organized screening programs, cervical cancer remains the second most common cause of death from cancer in women worldwide, as developing countries lack resources for universal, high-quality screening. In the United States, HPV-related OPC is only 1 of 5 cancers with a rising incidence since 1975 and now has taken over the cervix as the most common site of HPV-related cancer...
March 27, 2017: Cancer
https://www.readbyqxmd.com/read/28339040/detection-assay-for-hpv16-and-hpv18-by-loop%C3%A2-mediated-isothermal-amplification-with-lateral-flow-dipstick-tests
#20
Ratchanida Kumvongpin, Patcharee Jearanaikoon, Chotchana Wilailuckana, Nattaya Sae-Ung, Prinya Prasongdee, Sakda Daduang, Metee Wongsena, Patcharee Boonsiri, Wansika Kiatpathomchai, Sukumarn Sanersak Swangvaree, Alisa Sandee, Jureerut Daduang
Cervical cancer is the third highest cause of death in developing countries and most commonly results from high‑risk human papillomavirus (HR‑HPV) infection. Among HR‑HPV genotypes, HPV16 and HPV18 are the most prevalent in cervical cancers. Therefore, the present study aimed to develop a detection assay for HPV16 and HPV18 infection using loop‑mediated isothermal amplification (LAMP) with lateral flow dipstick (LFD) tests. This assay is a simplified, user‑friendly method for the visual detection of HPV genotypes...
May 2017: Molecular Medicine Reports
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