keyword
https://read.qxmd.com/read/38535293/integrative-analysis-of-cytokine-and-lipidomics-datasets-following-mild-traumatic-brain-injury-in-rats
#21
JOURNAL ARTICLE
Alexis N Pulliam, Alyssa F Pybus, David A Gaul, Samuel G Moore, Levi B Wood, Facundo M Fernández, Michelle C LaPlaca
Traumatic brain injury (TBI) is a significant source of disability in the United States and around the world and may lead to long-lasting cognitive deficits and a decreased quality of life for patients across injury severities. Following the primary injury phase, TBI is characterized by complex secondary cascades that involve altered homeostasis and metabolism, faulty signaling, neuroinflammation, and lipid dysfunction. The objectives of the present study were to (1) assess potential correlations between lipidome and cytokine changes after closed-head mild TBI (mTBI), and (2) examine the reproducibility of our acute lipidomic profiles following TBI...
February 21, 2024: Metabolites
https://read.qxmd.com/read/38534027/the-shift-in-the-fatty-acid-composition-of-the-circulating-lipidome-in-alzheimer-s-disease
#22
JOURNAL ARTICLE
Farida Dakterzada, Mariona Jové, José Luís Cantero, Natàlia Mota-Martorell, Reinald Pamplona, Gerard Piñoll-Ripoll
INTRODUCTION: Fatty acids (FAs) are the building blocks of complex lipids and signaling compounds; the role of the lipidome fatty acid profile (LFA) in AD progression remains unclear. METHODS: The LFA of plasma and cerebrospinal fluid (CSF) samples from 289 participants (103 AD patients, 92 MCI patients, and 94 controls) was determined by GC-FID. The MCI subjects were followed up for 58 ± 12.5 months. RESULTS: In controls, CSF has a more neuroprotective LFA than plasma...
March 27, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38533868/case-study-of-invalid-to-valid-shift-in-cognitive-performance-following-successful-treatment-of-psychogenic-nonepileptic-seizure-events
#23
JOURNAL ARTICLE
Daniel L Drane, Kelsey C Hewitt, Michele E Price, Beth K Rush, Karen Blackmon, Noah Okada, Taylor Shade, Edward Valentin, Joseph Vinson, Phyllis Rosen, David W Loring
Patients with psychogenic nonepileptic seizure (PNES) who fail performance validity testing (PVT) may appear to produce non-valid cognitive profiles. Consequently, they may not get referred to treatment and events persist, with worsening disability and high resource utilization. As a result, we report pre- and post-treatment neuropsychological evaluation findings in a 59-year-old woman with a confirmed diagnosis of PNES established using video-EEG monitoring. At pre-treatment baseline neuropsychological evaluation, PNES events occurred weekly to daily...
March 27, 2024: Journal of Clinical and Experimental Neuropsychology
https://read.qxmd.com/read/38533209/development-and-validation-of-an-interview-guide-for-examining-the-effects-of-sports-careers-on-the-quality-of-life-of-retired-portuguese-football-players
#24
JOURNAL ARTICLE
Eduardo Teixeira, Carlos Silva, António Vicente
INTRODUCTION: Considering the importance of assessing the impacts resulting from a sport career, this study aimed at developing and validating a semi-structure interview guide suitable for quantifying the sociodemographic and epidemiological profile of former professional football players. METHODS: Based on the theoretical frameworks and several methodological procedures, an interview guide was developed, consisting of 3 areas of conceptual organization (A1. Biographical data; A2...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38532577/just-a-gut-feeling-faecal-microbiota-transplant-for-treatment-of-depression-a-mini-review
#25
REVIEW
Minna Chang, Kai Tuomas Chang, Fuju Chang
BACKGROUND: The microbiota-gut-brain axis (MGBA) allows bidirectional crosstalk between the brain and gut microbiota (GM) and is believed to contribute to regulating mood/cognition/behaviour/metabolism/health and homeostasis. Manipulation of GM through faecal microbiota transplant (FMT) is a new, exciting and promising treatment for major depressive disorder (MDD). AIMS: This mini-review examines current research into GM and FMT as a therapy for depression. METHODS: Original research articles published in Medline/Cochrane Library/PubMed/EMBASE/PsycINFO databases/National Institute of Health website Clinicaltrials...
March 26, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38532534/unilateral-magnetic-resonance-imaging-guided-laser-interstitial-thermal-therapy-thalamotomy-for-essential-tremor
#26
JOURNAL ARTICLE
Mickael Aubignat, Mélissa Tir, Martial Ouendo, Salem Boussida, Jean-Marc Constans, Michel Lefranc
BACKGROUND: Essential tremor (ET) affects numerous adults, impacting quality of life (QOL) and often defying pharmacological treatment. Surgical interventions like deep brain stimulation (DBS) and lesional approaches, including radiofrequency, gamma-knife radiosurgery, and magnetic resonance imaging (MRI)-guided focused ultrasound, offer solutions but are not devoid of limitations. OBJECTIVES: This retrospective, single-center, single-blinded pilot study aimed to assess the safety and efficacy of unilateral MRI-guided laser interstitial thermal therapy (MRIg-LITT) thalamotomy for medically intractable ET...
March 26, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38532009/chronometric-tms-fmri-of-personalized-left-dorsolateral-prefrontal-target-reveals-state-dependency-of-subgenual-anterior-cingulate-cortex-effects
#27
JOURNAL ARTICLE
Sarah Grosshagauer, Michael Woletz, Maria Vasileiadi, David Linhardt, Lena Nohava, Anna-Lisa Schuler, Christian Windischberger, Nolan Williams, Martin Tik
Transcranial magnetic stimulation (TMS) applied to a left dorsolateral prefrontal cortex (DLPFC) area with a specific connectivity profile to the subgenual anterior cingulate cortex (sgACC) has emerged as a highly effective non-invasive treatment option for depression. However, antidepressant outcomes demonstrate significant variability among therapy plans and individuals. One overlooked contributing factor is the individual brain state at the time of treatment. In this study we used interleaved TMS-fMRI to investigate the influence of brain state on acute TMS effects, both locally and remotely...
March 26, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38531999/art-therapy-masks-reflect-emotional-changes-in-military-personnel-with-ptss
#28
JOURNAL ARTICLE
V Estrada Gonzalez, V Meletaki, M Walker, J Payano Sosa, A Stamper, R Srikanchana, J L King, K Scott, E R Cardillo, C Sours Rhodes, A P Christensen, K M Darda, C I Workman, A Chatterjee
Among disabling post-traumatic stress symptoms (PTSS) are irritability, aggressive behavior, distressing memories and general impaired cognition and negative mood. Art therapy interventions, including mask-making, can potentially alleviate these symptoms. We tested the hypothesis that art conveys emotions and predicted that blinded viewers would be able to perceive changes in theoretically derived emotional profiles expressed in art made by military personnel with PTSS from the onset to the end of therapy. Five service members and veterans exhibiting PTSS were enrolled in an 8-session art therapy protocol, during which they artistically transformed papier-mâché masks at the beginning and end of the protocol...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531240/neurodevelopmental-profile-in-children-born-to-mothers-affected-by-systemic-sclerosis
#29
JOURNAL ARTICLE
Jessica Galli, Erika Loi, Maria Grazia Lazzaroni, Anna Molinaro, Laura Andreoli, Marzia Bendoni, Liala Moschetti, Eleonora Pedretti, Lucrezia Maria Visconti, Paolo Airò, Franco Franceschini, Angela Tincani, Elisa Fazzi
BACKGROUND: Systemic sclerosis (SSc) is a chronic immune-mediated connective tissue disease that can affect women of childbearing age. The long-term outcomes of their offspring remain poorly explored. Aim of this study was to detail the neurodevelopmental profile of children born to SSc mothers. METHODS: Twenty children (mean age: 96 ± 4.32 months; 10 males) born to SSc mothers were enrolled. We collected data on clinical history, neurological examination, cognitive profile and adaptive behavior in all subjects...
March 19, 2024: Early Human Development
https://read.qxmd.com/read/38531143/characterizing-cognitive-subtypes-in-schizophrenia-using-cortical-curvature
#30
JOURNAL ARTICLE
Irina Papazova, Stephan Wunderlich, Boris Papazov, Ulrike Vogelmann, Daniel Keeser, Temmuz Karali, Peter Falkai, Susanne Rospleszcz, Isabel Maurus, Andrea Schmitt, Alkomiet Hasan, Berend Malchow, Sophia Stöcklein
Cognitive deficits are a core symptom of schizophrenia, but research on their neural underpinnings has been challenged by the heterogeneity in deficits' severity among patients. Here, we address this issue by combining logistic regression and random forest to classify two neuropsychological profiles of patients with high (HighCog) and low (LowCog) cognitive performance in two independent samples. We based our analysis on the cortical features grey matter volume (VOL), cortical thickness (CT), and mean curvature (MC) of N = 57 patients (discovery sample) and validated the classification in an independent sample (N = 52)...
March 21, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38530621/semantic-stroop-interference-is-modulated-by-the-availability-of-executive-resources-insights-from-delta-plot-analyses-and-cognitive-load-manipulation
#31
JOURNAL ARTICLE
Simone Sulpizio, Giacomo Spinelli, Michele Scaltritti
We investigated whether, during visual word recognition, semantic processing is modulated by attentional control mechanisms directed at matching semantic information with task-relevant goals. In previous research, we analyzed the semantic Stroop interference as a function of response latency (delta-plot analyses) and found that this phenomenon mainly occurs in the slowest responses. Here, we investigated whether this pattern is due to reduced ability to proactively maintain the task goal in these slowest trials...
March 26, 2024: Memory & Cognition
https://read.qxmd.com/read/38530142/single-nucleotide-polymorphisms-of-ankk1-ddr4-and-grin2b-genes-predict-behavior-in-a-prospective-cohort-of-mexican-children-and-adolescents
#32
JOURNAL ARTICLE
Barbara Moctezuma, Ángel Santiago, Ana Burguete-García, Jesus Martínez-Barnetche, Claudia Morales-Gómez, Carmen Hernandez-Chavez, Gabriela Gil, Karen E Peterson, Martha M Tellez-Rojo, Hector Lamadrid-Figueroa
Numerous studies have established associations between single nucleotide polymorphisms (SNPs) and various behavioral and neurodevelopmental conditions. This study explores the links between SNPs in candidate genes involved in central nervous system (CNS) physiology and their implications for the behavioral and emotional aspects in children and teenagers. A total of 590 participants, aged 7-15 years, from the Early Life Exposures In Mexico To Environmental Toxicants (ELEMENT) cohort study in Mexico City, underwent genotyping for at least one of 15 CNS gene-related SNPs at different timepoints...
March 26, 2024: International Journal of Developmental Neuroscience
https://read.qxmd.com/read/38529527/molecular-basis-underlying-changes-of-brain-entropy-and-functional-connectivity-in-major-depressive-disorders-after-electroconvulsive-therapy
#33
JOURNAL ARTICLE
Xiaohui Yu, Kexuan Chen, Yingzi Ma, Tongjian Bai, Shunli Zhu, Defang Cai, Xing Zhang, Kai Wang, Yanghua Tian, Jiaojian Wang
INTRODUCTION: Electroconvulsive therapy (ECT) is widely used for treatment-resistant depression. However, it is unclear whether/how ECT can be targeted to affect brain regions and circuits in the brain to dynamically regulate mood and cognition. METHODS: This study used brain entropy (BEN) to measure the irregular levels of brain systems in 46 major depressive disorder (MDD) patients before and after ECT treatment. Functional connectivity (FC) was further adopted to reveal changes of functional couplings...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38529416/behavioral-effects-of-visual-stimuli-in-adult-zebrafish-using-a-novel-eight-tank-imaging-system
#34
JOURNAL ARTICLE
Sayali V Gore, Thaís Del Rosario Hernández, Robbert Creton
INTRODUCTION: Animals respond to various environmental cues. Animal behavior is complex, and behavior analysis can greatly help to understand brain function. Most of the available behavioral imaging setups are expensive, provide limited options for customization, and allow for behavioral imaging of one animal at a time. METHODS: The current study takes advantage of adult zebrafish as a model organism to study behavior in a novel behavioral setup allowing one to concurrently image 8 adult zebrafish...
2024: Frontiers in Behavioral Neuroscience
https://read.qxmd.com/read/38528644/sourdough-bread-as-nutritional-intervention-tool-for-improvement-of-cognitive-dysfunction-in-diabetic-rats
#35
JOURNAL ARTICLE
Doha A Mohamed, Karem Fouda, Hoda B Mabrok, Marwa E El-Shamarka, Ibrahim M Hamed
BACKGROUND: The current research targeted to study the impact of nutritional intervention by two sourdough breads in improvement of cognitive dysfunction in diabetic rats. METHODS: Type-2 diabetes was induced in rats by Streptozotocin-Nicotinamide (STZ-NC). Diabetic rats were fed on balanced diet or balanced diet containing 20% of sourdough bread I or II for a month. Lipid profile, oxidative stress, inflammatory markers and cognitive functions were assessed in all rats...
March 26, 2024: BMC Nutrition
https://read.qxmd.com/read/38528588/epigenetic-scores-of-blood-based-proteins-as-biomarkers-of-general-cognitive-function-and-brain-health
#36
JOURNAL ARTICLE
Hannah M Smith, Joanna E Moodie, Karla Monterrubio-Gómez, Danni A Gadd, Robert F Hillary, Aleksandra D Chybowska, Daniel L McCartney, Archie Campbell, Paul Redmond, Danielle Page, Adele Taylor, Janie Corley, Sarah E Harris, Maria Valdés Hernández, Susana Muñoz Maniega, Mark E Bastin, Joanna M Wardlaw, Ian J Deary, James P Boardman, Donncha S Mullin, Tom C Russ, Simon R Cox, Riccardo E Marioni
BACKGROUND: Epigenetic Scores (EpiScores) for blood protein levels have been associated with disease outcomes and measures of brain health, highlighting their potential usefulness as clinical biomarkers. They are typically derived via penalised regression, whereby a linear weighted sum of DNA methylation (DNAm) levels at CpG sites are predictive of protein levels. Here, we examine 84 previously published protein EpiScores as possible biomarkers of cross-sectional and longitudinal measures of general cognitive function and brain health, and incident dementia across three independent cohorts...
March 25, 2024: Clinical Epigenetics
https://read.qxmd.com/read/38527942/the-relationship-between-motivation-profiles-for-health-oriented-physical-activity-basic-psychological-needs-and-emotional-regulation
#37
JOURNAL ARTICLE
Marta Vega-Díaz, Guillaume Martinent, Higinio González-García
The study of motivation toward health-oriented physical activity helps to know the reasons that guide people to practice physical activity. Moreover, different types and levels of motivation may coexist. As such, this paper aimed to analyze the combination of motivation for health-oriented physical activity profiles and examine whether profiles differed in emotional regulation and basic psychological needs. A sample of 808 Spanish adults between 18 and 65 years old ( M age = 33.90; Standard Deviation = 12...
March 25, 2024: Journal of Health Psychology
https://read.qxmd.com/read/38526765/the-role-of-concussion-history-and-biological-sex-on-baseline-concussion-clinical-profile-symptoms-in-adolescent-rugby-players
#38
JOURNAL ARTICLE
Connor McKee, Mark Matthews, Anthony P Kontos, Alan Rankin, Chris Bleakley
BACKGROUND: Accurate concussion monitoring requires access to preinjury baseline data. This is particularly important in adolescent athletes who have a high risk of concussion and are prone to prolonged recovery. As Rugby Union is governed by similar laws for men and women, it is also an ideal population to rigorously examine the impact of biological sex on concussion symptoms. AIMS: To evaluate self-reported concussion symptoms at baseline in adolescent rugby union players, and examine if subtype-specific symptoms are affected by concussion history and biological sex...
March 25, 2024: Irish Journal of Medical Science
https://read.qxmd.com/read/38526098/longer-sleep-duration-and-neuroinflammation-in-at-risk-elderly-with-a-parental-history-of-alzheimer-s-disease
#39
JOURNAL ARTICLE
Andrée-Ann Baril, Cynthia Picard, Anne Labonté, Erlan Sanchez, Catherine Duclos, Béry Mohammediyan, John C S Breitner, Sylvia Villeneuve, Judes Poirier
STUDY OBJECTIVES: While short sleep could promote neurodegeneration, long sleep may be a marker of ongoing neurodegeneration, potentially as a result of neuroinflammation. The objective was to evaluate sleep patterns with age of expected Alzheimer's disease (AD) onset and neuroinflammation. METHODS: We tested 203 dementia-free participants (68.5±5.4y/o, 78M). The PREVENT-AD cohort includes older persons with a parental history of AD whose age was nearing their expected AD onset...
March 25, 2024: Sleep
https://read.qxmd.com/read/38525594/adolescent-stress-induced-ventral-hippocampus-redox-dysregulation-underlies-behavioral-deficits-and-excitatory-inhibitory-imbalance-related-to-schizophrenia
#40
JOURNAL ARTICLE
Thamyris Santos-Silva, Caio Fábio Baeta Lopes, Doğukan Hazar Ülgen, Danielle A Guimarães, Francisco S Guimarães, Luciane Carla Alberici, Carmen Sandi, Felipe V Gomes
BACKGROUND AND HYPOTHESIS: Redox dysregulation has been proposed as a convergent point of childhood trauma and the emergence of psychiatric disorders, such as schizophrenia (SCZ). A critical region particularly vulnerable to environmental insults during adolescence is the ventral hippocampus (vHip). However, the impact of severe stress on vHip redox states and their functional consequences, including behavioral and electrophysiological changes related to SCZ, are not entirely understood...
March 25, 2024: Schizophrenia Bulletin
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