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https://www.readbyqxmd.com/read/27933285/developmental-profile-and-diagnoses-in-children-presenting-with-motor-stereotypies
#1
Francesco Cardona, Francesca Valente, Daniela Miraglia, Caterina D'Ardia, Valentina Baglioni, Flavia Chiarotti
INTRODUCTION: Motor stereotypies represent a typical example of the difficulty in distinguishing non-clinical behaviors (physiological and transient) from symptoms or among different disorders ["primary stereotypies," associated with autistic spectrum disorder (ASD), intellectual disabilities, genetic syndromes, and sensory impairment]. The aim of this study was to obtain an accurate assessment on the relationship between stereotypies and neurodevelopmental disorders. METHODS: We studied 23 children (3 girls), aged 36-95 months, who requested a consultation due to the persistence or increased severity of motor stereotypies...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27932974/patterns-of-longitudinal-neural-activity-linked-to-different-cognitive-profiles-in-parkinson-s-disease
#2
Atsuko Nagano-Saito, Mohamed S Al-Azzawi, Alexandru Hanganu, Clotilde Degroot, Béatriz Mejia-Constain, Christophe Bedetti, Anne-Louise Lafontaine, Valérie Soland, Sylvain Chouinard, Oury Monchi
Mild cognitive impairment in Parkinson's disease (PD) has been linked with functional brain changes. Previously, using functional magnetic resonance imaging (fMRI), we reported reduced cortico-striatal activity in patients with PD who also had mild cognitive impairment (MCI) vs. those who did not (non-MCI). We followed up these patients to investigate the longitudinal effect on the neural activity. Twenty-four non-demented patients with Parkinson's disease (non-MCI: 12, MCI: 12) were included in the study. Each participant underwent two fMRIs while performing the Wisconsin Card Sorting Task 20 months apart...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27932959/exposure-to-ketamine-anesthesia-affects-rat-impulsive-behavior
#3
António Melo, Hugo Leite-Almeida, Clara Ferreira, Nuno Sousa, José M Pêgo
Introduction: Ketamine is a general anesthetic (GA) that activates several neurotransmitter pathways in various part of the brain. The acute effects as GA are the most well-known and sought-after: to induce loss of responsiveness and to produce immobility during invasive procedures. However, there is a concern that repeated exposure might induce behavioral changes that could outlast their acute effect. Most research in this field describes how GA affects cognition and memory. Our work is to access if general anesthesia with ketamine can disrupt the motivational behavior trait, more specifically measuring impulsive behavior...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27932362/predicting-functional-decline-in-older-emergency-patients-the-safe-elderly-emergency-discharge-seed-project
#4
Judy A Lowthian, Lahn D Straney, Caroline A Brand, Anna Barker, P de Villiers Smit, Harvey Newnham, Peter Hunter, Cathie Smith, Peter A Cameron
OBJECTIVE: to profile the trajectory of, and risk factors for, functional decline in older patients in the 30 days following Emergency Department (ED) discharge. METHODS: prospective cohort study of community-dwelling patients aged ≥65 years, discharged home from a metropolitan Melbourne ED, 31 July 2012 to 30 November 2013. The primary outcome was functional decline, comprising either increased dependency in personal activities of daily living (ADL) or in skills required for living independently instrumental ADL (IADL), deterioration in cognitive function, nursing home admission or death...
December 7, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27932203/neural-connection-supporting-endogenous-5-hydroxytryptamine-influence-on-autonomic-activity-in-medial-prefrontal-cortex
#5
Hao-Qiang Zhang, Yong Zhang, Lin Liu, Jin-Lian Li, Ya-Cheng Lu, Ying-Ying Yu, Hui Li, Ting Zhang, Ying-Shing Chan, Fu-Xing Zhang, Yun-Qing Li
5-hydroxytryptamine (5-HT) transmission in the medial prefrontal cortex (mPFC) enhances or suppresses signal outflow to influence emotion-/cognition-based function performances and, putatively, the autonomic responses. The top-down cortical modulation of autonomic activities may be mediated in part through projections from mPFC to brain stem dorsal vagal complex (DVC). The abundant and heterogeneous densities of 5-HT fibers across laminae in mPFC suggest serotonergic innervation of mPFC-DVC projection neurons whereby endogenous 5-HT acts to regulate autonomic activities...
December 1, 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/27931119/assessing-cognitive-functioning-in-als-a-focus-on-frontal-lobe-processes
#6
S M Gillingham, Y Yunusova, A Ganda, E Rogaeva, S E Black, D T Stuss, L Zinman
OBJECTIVE: It is generally acknowledged that at least 50% of individuals with amyotrophic lateral sclerosis (ALS) will exhibit cognitive deficits outside of the characteristic motor neuron involvement. However, a specific cognitive profile has been difficult to ascertain due to disease-related testing barriers and limitations in the sensitivity and specificity of available assessment methods. This study assessed the level of functioning of extramotor frontal cognitive processes in ALS, and the amount of change in the functioning in these processes over time as disease progresses...
December 8, 2016: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/27929004/gamma-frequency-entrainment-attenuates-amyloid-load-and-modifies-microglia
#7
Hannah F Iaccarino, Annabelle C Singer, Anthony J Martorell, Andrii Rudenko, Fan Gao, Tyler Z Gillingham, Hansruedi Mathys, Jinsoo Seo, Oleg Kritskiy, Fatema Abdurrob, Chinnakkaruppan Adaikkan, Rebecca G Canter, Richard Rueda, Emery N Brown, Edward S Boyden, Li-Huei Tsai
Changes in gamma oscillations (20-50 Hz) have been observed in several neurological disorders. However, the relationship between gamma oscillations and cellular pathologies is unclear. Here we show reduced, behaviourally driven gamma oscillations before the onset of plaque formation or cognitive decline in a mouse model of Alzheimer's disease. Optogenetically driving fast-spiking parvalbumin-positive (FS-PV)-interneurons at gamma (40 Hz), but not other frequencies, reduces levels of amyloid-β (Aβ)1-40 and Aβ 1-42 isoforms...
December 7, 2016: Nature
https://www.readbyqxmd.com/read/27928746/affective-norms-for-720-french-words-rated-by-children-and-adolescents-fanchild
#8
Catherine Monnier, Arielle Syssau
FANchild (French Affective Norms for Children) provides norms of valence and arousal for a large corpus of French words (N = 720) rated by 908 French children and adolescents (ages 7, 9, 11, and 13). The ratings were made using the Self-Assessment Manikin (Lang, 1980). Because it combines evaluations of arousal and valence and includes ratings provided by 7-, 9-, 11-, and 13-year-olds, this database complements and extends existing French-language databases. Good response reliability was observed in each of the four age groups...
December 7, 2016: Behavior Research Methods
https://www.readbyqxmd.com/read/27925449/confirmatory-factor-analysis-of-a-questionnaire-measure-of-managerial-stigma-towards-employee-depression
#9
Angela J Martin, Rebecca Giallo
Managers' attitudes play a key role in how organizations respond to employees with depression. We examine the measurement properties of a questionnaire designed to assess managerial stigma towards employees with depression. Using data from a sample of 469 Australian managers representing a wide range of industries and work settings, we conducted a confirmatory factor analysis to assess three proposed subscales representing affective, cognitive and behavioural forms of stigma. Results were equivocal indicating acceptable fit for two-factor (affective and cognitive + behavioural), three-factor (affective, cognitive and behavioural) and higher order models...
December 2016: Stress and Health: Journal of the International Society for the Investigation of Stress
https://www.readbyqxmd.com/read/27924290/data-on-multicultural-education-and-diagnostic-information-profiling-culture-learning-styles-and-creativity
#10
Andino Maseleno, Glenn Hardaker, Noraisikin Sabani, Nabilah Suhaili
This article contains data related to multicultural education and diagnostic information profiling preliminary findings. It includes the responses of 253 students. The data consists of six sections, i) culture: race, ethnicity, language and identity; ii) learning preferences: physiological and perceptual; iii) cognitive learning styles: physical, emotional and mental; iv) creativity skills and problem solving skills; v) motivation; and vi) students' background knowledge. The data may be used as part of data analytics for specific personalized e-learning platform...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27924216/atrial-fibrillation-management-in-older-heart-failure-patients-a-complex-clinical-problem
#11
REVIEW
Giovanni Pulignano, Donatella Del Sindaco, Maria Denitza Tinti, Stefano Tolone, Giovanni Minardi, Antonio Lax, Massimo Uguccioni
BACKGROUND: Atrial fibrillation (AF) and heart failure (HF), two problems of growing prevalence as a consequence of the ageing population, are associated with high morbidity, mortality, and healthcare costs. AF and HF also share common risk factors and pathophysiologic processes such as hypertension, diabetes mellitus, ischemic heart disease, and valvular heart disease often occur together. Although elderly patients with both HF and AF are affected by worse symptoms and poorer prognosis, there is a paucity of data on appropriate management of these patients...
January 2016: Heart International
https://www.readbyqxmd.com/read/27923201/synthesis-and-biological-evaluation-of-a-new-class-of-benzothiazines-as-neuroprotective-agents
#12
Alessandra Mancini, Alessia Chelini, Angela Di Capua, Loretta Castelli, Simone Brogi, Marco Paolino, Germano Giuliani, Andrea Cappelli, Maria Frosini, Lorenzo Ricci, Erminia Leonelli, Gianluca Giorgi, Antonio Giordani, Jacopo Magistretti, Maurizio Anzini
Neurodegenerative diseases are disorders related to the degeneration of central neurons that gradually lead to various, severe alterations of cognitive and/or motor functions. Currently, for no such diseases does any pharmacological treatment exist able to arrest its progression. Riluzole (1) is a small molecule able to interfere with multiple cellular and molecular mechanisms of neurodegeneration, and is the only approved treatment of amyotrophic lateral sclerosis (ALS), the progression of which proved to significantly slow, thus increasing somewhat average survival...
November 27, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27921357/interrelationship-between-mini-mental-state-examination-scores-and-biochemical-parameters-in-patients-with-mild-cognitive-impairment-and-alzheimer-s-disease
#13
Ramasamy Vasantharekha, Hannah P Priyanka, Thangavel Swarnalingam, Avathvadi Venkatesan Srinivasan, Srinivasan ThyagaRajan
AIM: The aim of the present study was to provide first-hand information about the prevalence of mild cognitive impairment (MCI) and Alzheimer's disease (AD) in Tamil Nadu, a southern state in India, and examine if there exists a relationship between cognitive functions and biochemical parameters in these patients. METHODS: Surveys were collected from adults, older men and women (n = 3126) from different regions of Tamil Nadu, which were followed up after 12 months for 1337 participants...
December 6, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27920750/fluid-intelligence-as-a-mediator-of-the-relationship-between-executive-control-and-balanced-time-perspective
#14
Marcin Zajenkowski, Maciej Stolarski, Joanna Witowska, Oliwia Maciantowicz, Paweł Łowicki
This study examined the cognitive foundations of the balanced time perspective (BTP) proposed by Zimbardo and Boyd (1999). Although BTP is defined as the mental ability to switch effectively between different temporal perspectives, its connection with cognitive functioning has not yet been established. We addressed this by exploring the relationships between time perspectives and both fluid intelligence (measured with Raven's and Cattell's tests) and executive control (Go/No-go and anti-saccade tasks). An investigation conducted among Polish adults (N = 233) revealed that more balanced TP profile was associated with higher fluid intelligence, and higher executive control...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27919548/cognitive-decline-over-time-in-adults-with-myotonic-dystrophy-type-1-a-9-year-longitudinal-study
#15
Benjamin Gallais, Cynthia Gagnon, Jean Mathieu, Louis Richer
Myotonic dystrophy type 1 (DM1) is an inherited neuromuscular disease with multisystemic involvement including the central nervous system. The evolution of the cognitive profile is a matter of debate, whether an eventual decline could be global or process-specific. Study aims are to describe, compare and document the clinical relevance of the progression of cognitive abilities in DM1 patients with adult and late-onset phenotypes. A total of 115 DM1 patients (90 adult; 25 late-onset) were assessed twice within a 9-year period on cognitive abilities (language, memory, visual attention, processing speed, visuoconstructive abilities and executive functions) and intellectual functioning (WAIS-R 7)...
October 14, 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/27919482/the-association-of-cognitive-impairment-with-gray-matter-atrophy-and-cortical-lesion-load-in-clinically-isolated-syndrome
#16
Sevda Diker, Arzu Ceylan Has, Aslı Kurne, Rahşan Göçmen, Kader Karlı Oğuz, Rana Karabudak
BACKGROUND: Multiple sclerosis can impair cognition from the early stages and has been shown to be associated with gray matter damage in addition to white matter pathology. OBJECTIVES: To investigate the profile of cognitive impairment in clinically isolated syndrome (CIS), and the contribution of cortical inflammation, cortical and deep gray matter atrophy, and white matter lesions to cognitive decline. METHODS: Thirty patients with clinically isolated syndrome and twenty demographically- matched healthy controls underwent neuropsychologic assessment through the Rao Brief Repeatable Battery, and brain magnetic resonance imaging with double inversion recovery using a 3T scanner...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919474/a-study-of-cognitive-fatigue-in-multiple-sclerosis-with-novel-clinical-and-electrophysiological-parameters-utilizing-the-event-related-potential-p300
#17
Somasundaram Aadhimoolam Chinnadurai, Srinivasan Avathvadi Venkatesan, Gobinathan Shankar, Balasubramanian Samivel, Lakshmi Narasimhan Ranganathan
BACKGROUND: Although cognitive fatigue plays a significant part in Multiple Sclerosis (MS) related impairment, knowledge regarding it is largely lacking. Until now, not many tools are available to a clinician to detect cognitive fatigue. The subjective tools of fatigue have never been reliable.tabl OBJECTIVES: To assess the prevalence and clinical/ demographic profile of cognitive fatigue in MS using novel clinical and electrophysiological measures and to find their accuracy. We also aimed to test the three leading hypotheses - the temporal fatigue, cognitive load and cognitive domain hypotheses of cognitive fatigue in MS...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27916672/famous-faces-and-voices-differential-profiles-in-early-right-and-left-semantic-dementia-and-in-alzheimer-s-disease
#18
Simona Luzzi, Sara Baldinelli, Valentina Ranaldi, Katia Fabi, Viviana Cafazzo, Fabio Fringuelli, Mauro Silvestrini, Leandro Provinciali, Carlo Reverberi, Guido Gainotti
BACKGROUND: Famous face and voice recognition is reported to be impaired both in semantic dementia (SD) and in Alzheimer's Disease (AD), although more severely in the former. In AD a coexistence of perceptual impairment in face and voice processing has also been reported and this could contribute to the altered performance in complex semantic tasks. On the other hand, in SD both face and voice recognition disorders could be related to the prevalence of atrophy in the right temporal lobe (RTL)...
December 1, 2016: Neuropsychologia
https://www.readbyqxmd.com/read/27916665/task-modulations-and-clinical-manifestations-in-the-brain-functional-connectome-in-1615-fmri-datasets
#19
Tobias Kaufmann, Dag Alnæs, Christine Lycke Brandt, Nhat Trung Doan, Karolina Kauppi, Francesco Bettella, Trine V Lagerberg, Akiah O Berg, Srdjan Djurovic, Ingrid Agartz, Ingrid S Melle, Torill Ueland, Ole A Andreassen, Lars T Westlye
OBJECTIVE: An abundance of experimental studies have motivated a range of models concerning the cognitive underpinnings of severe mental disorders, yet the conception that cognitive and brain dysfunction is confined to specific cognitive domains and contexts has limited ecological validity. Schizophrenia and bipolar spectrum disorders have been conceptualized as disorders of brain connectivity; yet little is known about the pervasiveness across cognitive tasks. METHOD: To address this outstanding issue of context specificity, we estimated functional network connectivity from fMRI data obtained during five cognitive tasks (0-back, 2-back, go/no-go, recognition of positive faces, negative faces) in 90 patients with schizophrenia, 97 patients with bipolar spectrum disorder, and 136 healthy controls, including 1615 fMRI datasets in total...
December 1, 2016: NeuroImage
https://www.readbyqxmd.com/read/27916386/beneficial-effect-of-bilingualism-on-alzheimer-s-disease-csf-biomarkers-and-cognition
#20
Ainara Estanga, Mirian Ecay-Torres, Almudena Ibañez, Andrea Izagirre, Jorge Villanua, Maite Garcia-Sebastian, M Teresa Iglesias Gaspar, Ane Otaegui-Arrazola, Ane Iriondo, Monserrat Clerigue, Pablo Martinez-Lage
Bilingualism as a component of cognitive reserve has been claimed to delay the onset of Alzheimer's disease (AD). However, its effect on cerebrospinal fluid (CSF) AD-biomarkers has not been investigated. We assessed cognitive performance and CSF AD-biomarkers, and potential moderation effect of bilingualism on the association between age, CSF AD-biomarkers, and cognition. Cognitively healthy middle-aged participants classified as monolinguals (n = 100, nCSF = 59), early (n = 81, nCSF = 55) and late bilinguals (n = 97, nCSF = 52) were evaluated...
December 1, 2016: Neurobiology of Aging
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