keyword
MENU ▼
Read by QxMD icon Read
search

Cognitive profile

keyword
https://www.readbyqxmd.com/read/29916944/anxiety-depressive-symptoms-and-cardiac-autonomic-function-in-perimenopausal-and-postmenopausal-women-with-hot-flashes-a-brief-report
#1
Polly Fu, Carolyn J Gibson, Wendy Berry Mendes, Michael Schembri, Alison J Huang
OBJECTIVE: The aim of the study was to examine whether anxiety and depressive symptoms are associated with an adverse cardiac autonomic profile among midlife women with hot flashes. METHODS: Anxiety and depressive symptoms were evaluated by validated self-administered questionnaires among peri- and postmenopausal women in a randomized trial of slow-paced respiration for hot flashes. Pre-ejection period (PEP), a marker of sympathetic activation, and respiratory sinus arrhythmia (RSA), a marker of parasympathetic activation, were measured at baseline and 12 weeks using impedance cardiography and electocardiography...
June 18, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29916786/neuronal-population-responses-in-the-human-ventral-temporal-and-lateral-parietal-cortex-during-arithmetic-processing-with-digits-and-number-words
#2
Sori Baek, Amy L Daitch, Pedro Pinheiro-Chagas, Josef Parvizi
Past research has identified anatomically specific sites within the posterior inferior temporal gyrus (PITG) and the intraparietal sulcus (IPS) areas that are engaged during arithmetic processing. Although a small region of the PITG (known as the number form area) is selectively engaged in the processing of numerals, its surrounding area is activated during both digit and number word processing. In eight participants with intracranial electrodes, we compared the timing and selectivity of electrophysiological responses in the number form area-surround and IPS regions during arithmetic processing with digits and number words...
June 19, 2018: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/29915983/early-ethanol-exposure-induced-region-specific-changes-in-metabolic-proteins-in-the-rat-brain-a-proteomics-study
#3
Patricia C Swart, Vivienne A Russell, Nicolaas M Vlok, Jacqueline J Dimatelis
In utero exposure to alcohol has been shown to cause a spectrum of cognitive and behavioral deficits. This study aimed to explore the long-term effects of early-ethanol exposure on proteins in the brain. Male Sprague-Dawley rat pups were exposed to 12% ethanol (4 g/kg/day i.p.) or volume-controlled saline during the third human trimester equivalent (P4-P9). At P31, prefrontal cortex (PFC) and dorsal hippocampus (DH) proteins were analyzed by isobaric tags for relative and absolute quantitation (iTRAQ) and liquid chromatography mass spectrometry (LC-MS)...
June 18, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29915616/clinical-characteristics-and-type-of-antithrombotic-treatment-in-a-spanish-cohort-of-elderly-patients-with-atrial-fibrillation-according-to-dependency-frailty-and-cognitive-impairment
#4
Jose María Mostaza, Manuel Jesús Romero Jiménez, Fernando José Ruiz Laiglesia, José Antonio Díaz Peromingo, Manuel Beltrán Robles, Ernesto Guevara Sierra, Ana Santander Bilbao, Carmen Suárez
Background: Available data regarding clinical profile and management of elderly patients with atrial fibrillation (AF) according to dependency, fragility and cognitive impairment are scarce. The objective of the study was to analyze the biodemographic data, clinical profile and antithrombotic treatment according to dependency, fragility and cognitive impairment in elderly AF patients. Methods: Cross-sectional and multi-center study performed in consecutive AF patients ≥ 75 years treated with oral anticoagulants ≥ 3 months attended in Internal Medicine Departments in Spain...
April 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29914023/amyloid-mediated-cholinergic-dysfunction-in-motor-impairment-related-to-alzheimer-s-disease
#5
Tommaso Schirinzi, Francesco Di Lorenzo, Giulia Maria Sancesario, Giulia Di Lazzaro, Viviana Ponzo, Antonio Pisani, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana
BACKGROUND: Although motor disturbances parallel the course of dementia, worsening both quality of life and social costs, the pathogenesis remains still unclear. OBJECTIVE: Through the combination of cerebrospinal fluid (CSF) biomarkers assessment and transcranial magnetic stimulation (TMS) protocols, here we provided a cross-sectional study to understand pathogenic mechanisms of Alzheimer's disease (AD)-related early motor disturbances. METHODS: The motor phenotype, as defined with Unified Parkinson's Disease Rating Scale (UPDRS) part 2-3, Rating Scale for Gait Evaluation in Cognitive Deterioration (RSEGCD) and Tinetti scale, together with CSF profile of amyloid-β 42 (Aβ42), total-tau, and phosphorylated-tau were determined in 37 AD patients and compared to 18 patients with vascular dementia (VaD)...
June 8, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29914022/long-term-follow-up-of-patients-with-mild-to-moderate-alzheimer-s-disease-treated-with-bapineuzumab-in-a-phase-iii-open-label-extension-study
#6
Stephen P Salloway, Reisa Sperling, Nick C Fox, Marwan N Sabbagh, Lawrence S Honig, Anton P Porsteinsson, Hany Rofael, Nzeera Ketter, Daniel Wang, Enchi Liu, Stephen Carr, Ronald S Black, H Robert Brashear
BACKGROUND: A 3-year extension of two Phase III parent studies of intravenous (IV) bapineuzumab in patients with mild-to-moderate Alzheimer's disease dementia (apolipoprotein (APOE) ɛ4 carriers and noncarriers) is summarized. OBJECTIVES: The primary and secondary objectives were to evaluate the long-term safety, tolerability, and maintenance of efficacy of bapineuzumab. METHODS: A multicenter study in patients who had participated in double-blind placebo-controlled parent studies...
June 8, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29910744/yangxue-qingnao-wan-and-silibinin-capsules-the-two-chinese-medicines-attenuate-cognitive-impairment-in-aged-ldlr-golden-syrian-hamsters-involving-protection-of-blood-brain-barrier
#7
You-Yu Gu, Ping Huang, Quan Li, Yu-Ying Liu, George Liu, Yu-Hui Wang, Ming Yi, Li Yan, Xiao-Hong Wei, Lei Yang, Bai-He Hu, Xin-Rong Zhao, Xin Chang, Kai Sun, Chun-Shui Pan, Yuan-Chen Cui, Qing-Fang Chen, Chuan-She Wang, Jing-Yu Fan, Zhi-Zhong Ma, Jing-Yan Han
The purpose of the study was to explore the effect and the underlying mechanism of YangXue QingNao Wan (YXQNW) and Silibinin Capsules (SC), the two Chinese medicines, on cognitive impairment in older people with familial hyperlipidaemia. Fourteen month-old female LDLR (+/-) golden Syrian hamsters were used with their wild type as control. YXQNW (0.5 g/kg/day), SC (0.1 g/kg/day), or YXQNW (0.5 g/kg/day) + SC (0.1 g/kg/day) were administrated orally for 30 days. To assess the effects of the two drugs on plasma lipid content and cognitive ability, plasma TC, TG, LDL-C, and HDL-C were measured, and Y maze task was carried out both before and after administration...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29908718/effects-of-cognitive-and-motor-rehabilitation-in-non-convulsive-status-epilepticus-a-case-report
#8
Francesco Corallo, Viviana Lo Buono, Marcella Di Cara, Simona De Salvo, Giuliana Vermiglio, Patrizia Pollicino, Placido Bramanti, Silvia Marino, Carmela Rifici
Epilepsy is a neurological disorder characterized by recurrent and unpredictable interruptions of normal brain function, that implies neurobiologic, psychological, and social consequences. Non-convulsive status epilepticus (NCSE) is an electro-clinical state associated to altered level of consciousness. In NCSE could occur the behavioural and emotional disorder, cognitive impairment and psychiatric disorder with a negative impact on quality of life and adaptive social behaviours. Cognitive rehabilitation for epileptic patients may include internal compensation strategies, external memory aids, psychoeducation, verbal and visual memory training, attention exercise and executive functions...
June 13, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29907968/bipolar-disorder-type-i-and-ii-show-distinct-relationships-between-cortical-thickness-and-executive-function
#9
C Abé, S Rolstad, P Petrovic, C-J Ekman, T Sparding, M Ingvar, M Landén
OBJECTIVE: Frontal cortical abnormalities and executive function impairment co-occur in bipolar disorder. Recent studies have shown that bipolar subtypes differ in the degree of structural and functional impairments. The relationships between cognitive performance and cortical integrity have not been clarified and might differ across patients with bipolar disorder type I, II, and healthy subjects. METHOD: Using a vertex-wise whole-brain analysis, we investigated how cortical integrity, as measured by cortical thickness, correlates with executive performance in patients with bipolar disorder type I, II, and controls (N = 160)...
June 15, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29907381/implementation-of-the-frailty-index-in-hospitalized-older-patients-results-from-the-reposi-register
#10
M Cesari, C Franchi, L Cortesi, A Nobili, I Ardoino, P M Mannucci
BACKGROUND: Frailty is a state of increased vulnerability to stressors, associated to poor health outcomes. The aim of this study was to design and introduce a Frailty Index (FI; according to the age-related accumulation of deficit model) in a large cohort of hospitalized older persons, in order to benefit from its capacity to comprehensively weight the risk profile of the individual. METHODS: Patients aged 65 and older enrolled in the REPOSI register from 2010 to 2016 were considered in the present analyses...
June 12, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29905772/nrf2-deficiency-exacerbates-obesity-induced-oxidative-stress-neurovascular-dysfunction-blood-brain-barrier-disruption-neuroinflammation-amyloidogenic-gene-expression-and-cognitive-decline-in-mice-mimicking-the-aging-phenotype
#11
Stefano Tarantini, M Noa Valcarcel-Ares, Andriy Yabluchanskiy, Zsuzsanna Tucsek, Peter Hertelendy, Tamas Kiss, Tripti Gautam, Xin A Zhang, William E Sonntag, Rafael de Cabo, Eszter Farkas, Michael H Elliott, Michael T Kinter, Ferenc Deak, Zoltan Ungvari, Anna Csiszar
Obesity has deleterious effects on cognitive function in the elderly adults. In mice, aging exacerbates obesity-induced oxidative stress, microvascular dysfunction, blood-brain barrier (BBB) disruption, and neuroinflammation, which compromise cognitive health. However, the specific mechanisms through which aging and obesity interact to remain elusive. Previously, we have shown that Nrf2 signaling plays a critical role in microvascular resilience to obesity and that aging is associated with progressive Nrf2 dysfunction, promoting microvascular impairment...
June 14, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29901790/neurocognitive-profiles-of-older-adults-with-working-memory-dysfunction
#12
Alireza Salami, Anna Rieckmann, Nina Karalija, Bárbara Avelar-Pereira, Micael Andersson, Anders Wåhlin, Goran Papenberg, Douglas D Garrett, Katrine Riklund, Martin Lövdén, Ulman Lindenberger, Lars Bäckman, Lars Nyberg
Individuals differ in how they perceive, remember, and think. There is evidence for the existence of distinct subgroups that differ in cognitive performance within the older population. However, it is less clear how individual differences in cognition in old age are linked to differences in brain-based measures. We used latent-profile analysis on n-back working-memory (WM) performance to identify subgroups in a large sample of older adults (n = 181; age = 64-68 years). Our analysis identified one larger normal subgroup with higher performance (n = 113; 63%), and a second smaller subgroup (n = 55; 31%) with lower performance...
July 1, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29901746/brain-mri-fiber-tracking-reveals-white-matter-alterations-in-hypertensive-patients-without-damage-at-conventional-neuroimaging
#13
Lorenzo Carnevale, Valentina D'Angelosante, Alessandro Landolfi, Giovanni Grillea, Giulio Selvetella, Marianna Storto, Giuseppe Lembo, Daniela Carnevale
Aims: Hypertension is one of the main risk factor for dementia. The subtle damage provoked by chronic high blood pressure in the brain is usually evidenced by conventional magnetic resonance imaging (MRI), in terms of white matter (WM) hyperintensities or cerebral atrophy. However, it is clear that by the time brain damage is visible, it may be too late hampering neurodegeneration. Aim of this study was to characterize a signature of early brain damage induced by hypertension, before the neurodegenerative injury manifests...
June 12, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29900257/dataset-on-gene-expression-in-the-elderly-after-mindfulness-awareness-practice-or-health-education-program
#14
Hwee-Woon Lim, Woei-Yuh Saw, Lei Feng, Yuan-Kun Lee, Ratha Mahendran, Irwin Kee-Mun Cheah, Iris Rawtaer, Alan Prem Kumar, Ee-Heok Kua, Rathi Mahendran, Ene-Choo Tan
It has been reported that relaxation techniques can improve physical health and cognitive function. A number of studies involving different types of relaxation practices showed changes in expression of genes. We investigated the gene expression pattern of a cohort of elderly subjects of Asian descent after weekly (for the first three months) and monthly (for the subsequent six months) intervention. Sixty consenting elderly subjects (aged 60-90 years) with mild cognitive impairment were assigned to either the Mindfulness Awareness Practice (MAP) or Health Education Program (HEP) group in a randomized controlled trial to assess the effectiveness of the programs in preventing further cognitive decline and evaluate the influence on neurological, cellular and biochemical factors...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29899731/early-gray-matter-volume-loss-in-mapt-h1h1-de-novo-pd-patients-a-possible-association-with-cognitive-decline
#15
Frederic Sampedro, Juan Marín-Lahoz, Saul Martínez-Horta, Javier Pagonabarraga, Jaime Kulisevsky
The MAPT H1 haplotype has been identified as a predictor of cognitive decline in Parkinson's disease (PD). However, its underlying pathological mechanisms have not been fully established. In this work, using a cohort of 120 de novo PD patients with preserved cognition from the Parkinson's Progression Markers Initiative (PPMI) database, we found that patients who were homozygous for MAPT H1 had less gray matter volume (GMV) and greater 1-year GMV loss than patients without this genetic profile. Importantly, these changes were associated with a longitudinal worsening of cognitive indicators...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29898969/increased-caide-dementia-risk-cognition-csf-biomarkers-and-vascular-burden-in-healthy-adults
#16
Mirian Ecay-Torres, Ainara Estanga, Mikel Tainta, Andrea Izagirre, Maite Garcia-Sebastian, Jorge Villanua, Montserrat Clerigue, Ane Iriondo, Iratxe Urreta, Arantzazu Arrospide, Carmen Díaz-Mardomingo, Miia Kivipelto, Pablo Martinez-Lage
OBJECTIVE: To investigate the cognitive profile of healthy individuals with increased Cardiovascular Risk Factors, Aging and Dementia (CAIDE) dementia risk score and to explore whether this association is related to vascular burden and CSF biomarkers of amyloidosis and neurodegeneration. METHOD: Cognitively normal participants (mean age 57.6 years) from the Gipuzkoa Alzheimer Project study were classified as having high risk (HR; n = 82) or low risk (LR; n = 293) for dementia according to a CAIDE score cutoff of 9...
June 13, 2018: Neurology
https://www.readbyqxmd.com/read/29897434/the-c-abl-inhibitor-radotinib-hcl-is-neuroprotective-in-a-preclinical-parkinson-s-disease-mouse-model
#17
Saebom Lee, Sangjune Kim, Yong Joo Park, Seung Pil Yun, Seung-Hwan Kwon, Donghoon Kim, Dong Yeon Kim, Jae Soo Shin, Dae Jin Cho, Gong Yeal Lee, Hyun Soo Ju, Hyo Jung Yun, Jae Hong Park, Wonjoong Richard Kim, Eun Ah Jung, Seulki Lee, Han Seok Ko
Accumulating evidence suggests that the nonreceptor tyrosine kinase c-Abl plays an important role in the progression of Parkinson's disease (PD) and c-Abl inhibition could be neuroprotective in PD and related α-synucleinopathies. Nilotinib, a c-Abl inhibitor, has shown improved motor and cognitive symptoms in PD patients. However, issues concerning blood-brain barrier (BBB) penetration, lack of selectivity, and safety still remain. Radotinib HCl is a selective Bcr-Abl kinase inhibitor that not only effectively access the brain, but also exhibits greater pharmacokinetic properties and safety profiles compared to Nilotinib and other c-Abl inhibitors...
April 20, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29896231/identification-of-genes-and-pathways-related-with-cerebral-small-vessel-disease-based-on-a-long-non-coding-rna-mediated-competitive-endogenous-rna-network
#18
Hui Yan, Xiaoli Yang, Xueman Zhao, Huankun Wang
This study aimed to investigate the cerebral small vessel disease (SVD), an intrinsic disorder of the brain's perforating arterioles, which could cause serious cognitive decreasing and trigger dementia. In this study, we present a multi-step computational approach to construct a functional SVD long non-coding RNA (lncRNA)-mediated ceRNA network (LMCN) by integrating genome-wide lncRNA and mRNA expression profiles, miRNA-target interactions, and functional analyses. We used hypergeometric test to evaluate enrichment significance of miRNAs and we obtained the LMCN, which contained 27 lncRNAs, 7,229 mRNA, and 28,871 lncRNAs-mRNA interrelationship pairs...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29895873/cognitive-appraisals-and-emotional-status-following-a-spinal-cord-injury-in-post-acute-rehabilitation
#19
Rebecca Eaton, Kevin Jones, Jane Duff
STUDY DESIGN: Retrospective, cross-sectional study. OBJECTIVES: To investigate the factor structure of the ADAPSS-short form (ADAPSS-SF) in an acutely injured SCI population and to assess the relationship between cognitive appraisals made in the initial phase of rehabilitation and the experience of anxiety and depression. SETTING: National Spinal Injuries Centre, UK. METHOD: Participants were acutely injured patients admitted to the NSIC over 35 months...
June 12, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29895708/a-peptidomic-approach-to-characterize-peptides-involved-in-cerebellar-cortex-development-leads-to-the-identification-of-the-neurotrophic-effects-of-nociceptin
#20
Auriane Corbière, Marie-Laure Walet-Balieu, Philippe Chan, Magali Basille-Dugay, Julie Hardouin, David Vaudry
The cerebellum is a brain structure involved in motor and cognitive functions. The development of the cerebellar cortex (the external part of the cerebellum) is under the control of numerous factors. Among these factors, neuropeptides including PACAP or somatostatin modulate the survival, migration and/or differentiation of cerebellar granule cells. Interestingly, such peptides contributing to cerebellar ontogenesis usually exhibit a specific transient expression profile with a low abundance at birth, a high expression level during the developmental processes, which take place within the first two postnatal weeks in rodents, and a gradual decline toward adulthood...
June 12, 2018: Molecular & Cellular Proteomics: MCP
keyword
keyword
53472
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"