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https://www.readbyqxmd.com/read/29129178/cortisone-injections-for-tennis-elbow-should-be-an-avoid-rather-than-a-recommended-procedure
#1
John W Orchard, Bill Vicenzino
No abstract text is available yet for this article.
November 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29120451/effect-of-maternal-smoking-on-stress-physiology-in-healthy-neonates
#2
C Haslinger, H Bamert, M Rauh, T Burkhardt, L Schäffer
OBJECTIVE: To assess the impact of maternal smoking during pregnancy (MSDP) on the neonatal hypothalamic-pituitary-adrenal axis. STUDY DESIGN: In a prospective observational study, salivary cortisol and cortisone levels were measured at the fourth day of life during resting conditions and in response to a pain-induced stress event in healthy neonates whose mothers smoked cigarettes during each stage of pregnancy and compared with controls. RESULTS: Neonates in the control group (n=70) exhibited a physiologic stress response with a significant increase in cortisol (1...
November 9, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29108639/proteomic-profiling-reveals-sub-proteomes-of-the-human-placenta
#3
Wendy E Heywood, Rhian-Lauren Preece, Jeremy Pryce, Jenny Hallqvist, Robert Clayton, Alex Virasami, Kevin Mills, Neil J Sebire
Proteomic characterisation of the placenta has largely been focused on effect of disease, anatomical features or specific cell types. We describe an unbiased proteomic mapping analysis to investigate how the placental proteome changes throughout the organ. A transverse slice of a human placenta was sectioned into 1 × 1cm samples. Sections were analysed using label free proteomics. Analysis revealed two distinct sub-proteomes that did not have anatomical significance. One had a muscular proteome and the other had distinct immunomodulation functions...
November 2017: Placenta
https://www.readbyqxmd.com/read/29106701/use-of-salivary-cortisol-and-cortisone-in-the-high-and-low-dose-synacthen-test
#4
Charlotte J Elder, Robert F Harrison, Alexandra S Cross, Ruben Vilela, Brian G Keevil, Neil P Wright, Richard J Ross
CONTEXT: Salivary cortisone reflects serum cortisol levels, is more sensitive than salivary cortisol at lower values of serum cortisol and is non-invasive. OBJECTIVE: To investigate the relationship between serum cortisol and salivary cortisol and cortisone following low and high-dose synacthen. DESIGN AND SETTING: Prospective pharmacodynamic studies in clinical research facilities. PARTICIPANTS AND INTERVENTION: 35 dexamethasone-suppressed, healthy adult males underwent an intravenous synacthen test: N=23 low-dose (1mcg), N=12 high-dose (250mcg)...
November 6, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29095280/primary-hypothyroidism-and-isolated-acth-deficiency-induced-by-nivolumab-therapy-case-report-and-review
#5
REVIEW
Mei Fang Zeng, Li Chen, Hong Ying Ye, Wei Gong, Li Nuo Zhou, Yi Ming Li, Xiao Long Zhao
RATIONALE: Nivolumab is a monoclonal IgG antibody blocking programmed death receptor-1 (PD1), leading to restoration of the natural T-cell-mediated immune response against the cancer cells. However, it also causes plenty of autoimmune-related adverse events, which often involves endocrine system. PATIENT CONCERNS: A 54-year-old male with renal clear cell carcinoma was treated with nivolumab intravenously. Routine monitoring showed elevated thyroid-stimulating hormone and low free thyroxine after the 6th administration of nivolumab...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29095118/screening-and-quantification-of-18-glucocorticoid-adulterants-from-herbal-pharmaceuticals-and-health-foods-by-hplc-and-confirmed-by-lc-q-tof-ms-ms
#6
Pengfei Jin, Xiaoli Liang, Xuejun Wu, Xiaorong He, Yongmei Kuang, Xin Hu
A procedure for the screening and quantification of 18 glucocorticoids, i.e. hydrocortisone sodium succinate (HSS), prednisolone (PDL), prednisone (PDS), hydrocortisone (HCS), methylprednisolone (MPS), betamethasone (BTM), dexamethasone (DXM), triamcinolone acetonide (TA), prednisolone acetate (PLA), hydrocortisone acetate (HA), fludrocortisone acetate (FA), prednisone acetate (PA), cortisone acetate (CA), dexamethasone acetate (DA), hydrocortisone butyrate (HB), triamcinolone acetonide acetate (TAA), fluocinonide (FN) and halcinonide (HC) from herbal pharmaceuticals and health foods was established and fully validated...
November 14, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29079239/osteochondroma-of-the-cuboid-a-case-report
#7
Jeffrey M Whitaker, Grace C Craig, Sadie Winship
Osteochondromas are common benign exostoses with <1% of pedal occurrences. Several cases of osteochondromas have been previously reported in the foot and ankle but none from the cuboid. In the present study, we report a case of osteochondroma originating from the cuboid in a 29-year-old male patient. The patient presented with an aching and shooting pain to his left foot that had progressed during the course of 3 years. Originally diagnosed as a fibroma, the patient had undergone cortisone injections that did not help with his symptoms...
November 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29078321/identification-of-a-tumor-promoter-cholesterol-metabolite-in-human-breast-cancers-acting-through-the-glucocorticoid-receptor
#8
Maud Voisin, Philippe de Medina, Arnaud Mallinger, Florence Dalenc, Emilie Huc-Claustre, Julie Leignadier, Nizar Serhan, Régis Soules, Grégory Ségala, Aurélie Mougel, Emmanuel Noguer, Loubna Mhamdi, Elodie Bacquié, Luigi Iuliano, Chiara Zerbinati, Magali Lacroix-Triki, Léonor Chaltiel, Thomas Filleron, Vincent Cavaillès, Talal Al Saati, Philippe Rochaix, Raphaelle Duprez-Paumier, Camille Franchet, Laetitia Ligat, Fréderic Lopez, Michel Record, Marc Poirot, Sandrine Silvente-Poirot
Breast cancer (BC) remains the primary cause of death from cancer among women worldwide. Cholesterol-5,6-epoxide (5,6-EC) metabolism is deregulated in BC but the molecular origin of this is unknown. Here, we have identified an oncometabolism downstream of 5,6-EC that promotes BC progression independently of estrogen receptor α expression. We show that cholesterol epoxide hydrolase (ChEH) metabolizes 5,6-EC into cholestane-3β,5α,6β-triol, which is transformed into the oncometabolite 6-oxo-cholestan-3β,5α-diol (OCDO) by 11β-hydroxysteroid-dehydrogenase-type-2 (11βHSD2)...
October 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29076454/-bursitis-after-vaccination-in-the-shoulder-region
#9
Henning Bliddal, Søren Torp-Pedersen, Birgit Falk-Riecke, Else Bartels
Shoulder pain may develop after vaccination in the deltoid area due to inadvertent injection of the vaccine into the subdeltoid bursa, which may be located close to the skin. As far as we know, such vaccination reactions occur more frequently than officially registered, and doctors may not be aware of the problem. We present two of these cases of a suspected inflammatory reaction in the shoulder bursa after vaccination. Injection of cortisone in the bursa may relieve the reaction to some extent, but chronic shoulder pain may develop...
October 23, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29074841/a-network-pharmacology-approach-to-determine-the-active-components-and-potential-targets-of-curculigo-orchioides-in-the-treatment-of-osteoporosis
#10
Nani Wang, Guizhi Zhao, Yang Zhang, Xuping Wang, Lisha Zhao, Pingcui Xu, Dan Shou
BACKGROUND Osteoporosis is a complex bone disorder with a genetic predisposition, and is a cause of health problems worldwide. In China, Curculigo orchioides (CO) has been widely used as a herbal medicine in the prevention and treatment of osteoporosis. However, research on the mechanism of action of CO is still lacking. The aim of this study was to identify the absorbable components, potential targets, and associated treatment pathways of CO using a network pharmacology approach. MATERIAL AND METHODS We explored the chemical components of CO and used the five main principles of drug absorption to identify absorbable components...
October 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29073819/evaluation-of-hair-cortisol-and-cortisone-change-during-pregnancy-and-the-association-with-self-reported-depression-somatization-and-stress-symptoms
#11
Friederike Scharlau, Diana Pietzner, Mandy Vogel, Alexander Gaudl, Uta Ceglarek, Joachim Thiery, Jürgen Kratzsch, Andreas Hiemisch, Wieland Kiess
Hair cortisol levels are used to measure long-term stress, while its inactive metabolite cortisone is often not assessed. We measured hair cortisol concentrations (HCC) and hair cortisone concentrations (HCNC) via liquid chromatography quadrupole linear ion trap mass spectrometry (LC-MS(3)) in 62 pregnant women who participated in the LIFE CHILD STUDY in their 2nd and 3rd trimester between 12/2011 and 11/2014. Sociodemographic factors, pregnancy-related factors, and hair characteristics were assessed. Degree of severity of depression, somatization, and stress were evaluated in both trimesters with a self-reported Patient Health Questionnaire (PHQ)...
October 26, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29073307/a-follow-up-history-of-young-man-with-apparent-cortisone-reductase-deficiency-acrd-several-years-after-diagnosis
#12
Adrianna Zajkowska, Marta Rydzewska, Katarzyna Wojtkielewicz, Janusz Pomaski, Tomasz Romer, Artur Bossowski
INTRODUCTION: Inactivating mutations in the enzyme hexose-6-phosphate dehydrogenase (H6PDH), the enzyme responsible for NADPH generation playing critical role in 11-hydroxysteroid dehydrogenase type 1 (11b-HSD1) activity, cause apparent cortisone reductase deficiency (ACRD). It leads to increased metabolic clearance rate of cortisol due to a defect in cortisone to cortisol conversion by 11b-HSD1. We want to analyse the process of the disease, efficacy of long-lasting treatment with glucocorticoids throughout childhood and adolescence in only male patient with ACRD...
2017: Pediatric Endocrinology, Diabetes, and Metabolism
https://www.readbyqxmd.com/read/29064428/diurnal-hypothalamic-pituitary-adrenal-axis-measures-and-inflammatory-marker-correlates-in-major-depressive-disorder
#13
Kelly Doolin, Chloe Farrell, Leonardo Tozzi, Andrew Harkin, Thomas Frodl, Veronica O'Keane
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and inflammatory systems is a consistent finding in patients with Major Depressive Disorder (MDD). Cortisol is often assessed by measurement of the cortisol awakening response (CAR) and/or diurnal cortisol levels. Some methods of cortisol measurement overestimate cortisol concentration due to detection of other glucocorticoids including the relatively inert cortisone, therefore this study aimed to assess the presence of both cortisol and cortisone, and the cortisol-cortisone catalyzing enzyme 11β-hydroxysteroiddehydrogenase type 1 (11β-HSD1), in depressed patients and controls...
October 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29061472/quantification-of-steroid-hormones-in-human-serum-by-liquid-chromatography-high-resolution-tandem-mass-spectrometry
#14
Silke Matysik, Gerhard Liebisch
A limited specificity is inherent to immunoassays for steroid hormone analysis. To improve selectivity mass spectrometric analysis of steroid hormones by liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been introduced in the clinical laboratory over the past years usually with low mass resolution triple-quadrupole instruments or more recently by high resolution mass spectrometry (HR-MS). Here we introduce liquid chromatography-high resolution tandem mass spectrometry (LC-MS/HR-MS) to further increase selectivity of steroid hormone quantification...
December 1, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29055783/prenatal-organochlorine-pesticide-exposure-and-the-disruption-of-steroids-and-reproductive-hormones-in-cord-blood-the-hokkaido-study
#15
Atsuko Araki, Chihiro Miyashita, Takahiko Mitsui, Houman Goudarzi, Futoshi Mizutani, Youichi Chisaki, Sachiko Itoh, Seiko Sasaki, Kazutoshi Cho, Kimihiko Moriya, Nobuo Shinohara, Katsuya Nonomura, Reiko Kishi
Certain organochlorine pesticides (OCPs) are designated as persistent organic pollutants and are regulated in many countries. The effects of OCPs on pediatric endocrinology are a concern; however, only limited data exist from human studies on maternal OCP exposure and its effects on infants' hormone levels. This study was conducted as part of the Hokkaido Study Sapporo Cohort, a prospective birth cohort study in Japan. Participants included 514 women who enrolled at 23-35weeks of gestation between 2002 and 2005; maternal blood samples were collected in late pregnancy, and 29 OCPs were measured...
January 2018: Environment International
https://www.readbyqxmd.com/read/29041020/-pilot-study-on-the-effects-and-benefits-of-autologous-fat-grafting-in-osteoarthritis-of-the-cmc-1-joint-compared-to-intraarticular-cortisone-injection-results-after-3-months
#16
Elisabeth Maria Haas, Elias Volkmer, Riccardo E Giunta
Background/Aim Preliminary data suggest that an intraarticular autologous fat transplant may be useful in osteoarthritis (OA) of the CMC-1 joint. This prospective, non-randomised pilot study investigates this new method with a view to clinical outcomes compared with intraarticular corticosteroid injection. Patients and Methods 17 women and 7 men with an average age of 63.3 (47-75) years with symptomatic OA were included in the study. In 12 patients, a radiologically guided injection of 1-1.5 ml of adipose tissue was carried out after transumbilical liposuction of 10 ml of abdominal fat...
October 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29040586/plasma-nervonic-acid-is-a-potential-biomarker-for-major-depressive-disorder-a-pilot-study
#17
Yuki Kageyama, Takaoki Kasahara, Takemichi Nakamura, Kotaro Hattori, Yasuhiko Deguchi, Munehide Tani, Kenji Kuroda, Sumiko Yoshida, Yu-Ichi Goto, Koki Inoue, Tadafumi Kato
Background: Diagnostic biomarkers of major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ) are urgently needed because none are currently available. Methods: We performed a comprehensive metabolome analysis of plasma samples from drug-free patients with MDD (n = 9), BD (n = 6), SZ (n = 17), and matched healthy controls (n = 19) (cohort 1), using liquid chromatography time-of-flight mass spectrometry. A significant effect of diagnosis was found for two metabolites: nervonic acid and cortisone, with nervonic acid being the most significantly altered...
October 6, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29026058/clinical-utility-of-late-night-and-post-overnight-dexamethasone-suppression-salivary-cortisone-for-the-investigation-of-cushing-s-syndrome
#18
C M Ng, T K Lam, Y C Au Yeung, C H Choi, Y P Iu, C C Shek, S C Tiu
INTRODUCTION: There is a pressing need to identify diagnostic testing for Cushing's syndrome that can be achieved with ease and at low cost. This study aimed to explore the usefulness of late-night and post-overnight 1-mg dexamethasone suppression salivary cortisone, as measured by liquid chromatography-tandem mass spectrometry, for investigation of hypercortisolism. METHODS: Salivary cortisone data of subjects were investigated according to a pre-specified protocol...
October 13, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29020429/pachychoroid-pigment-epitheliopathy-associated-with-tamoxifen
#19
Mehmet Giray Ersoz, Serra Arf, Murat Karacorlu, Mumin Hocaoglu, Isil Sayman Muslubas
Pachychoroid pigment epitheliopathy (PPE) is considered to be a forme fruste of central serous chorioretinopathy. Tamoxifen (Soltamax; Midatech Pharma, Raleigh, NC) has an anti-estrogenic effect on cytoplasmic estrogen receptors. Serum total testosterone, cortisol, and cortisone levels increase during tamoxifen therapy. Tamoxifen may cause hormone disturbance leading to the development of disorders in the pachychoroid spectrum. The authors present two cases of PPE associated with tamoxifen therapy. A 65-year-old woman (Patient 1) and a 52-year-old woman (Patient 2) had a recent history of tamoxifen therapy...
October 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29017692/misuse-of-cortisone-eyedrops
#20
Jean-Cyriaque Barry
No abstract text is available yet for this article.
September 22, 2017: Deutsches Ärzteblatt International
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