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Cortisone

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https://www.readbyqxmd.com/read/28211290/is-there-a-short-term-benefit-from-an-intra-articular-steroid-injection-in-female-patients-with-adhesive-capsulitis-of-the-shoulder-treated-with-physiotherapy
#1
Krishna Kumar, Ancy Thomas, Kevin Tetsworth, Erik Hohmann
INTRODUCTION: The purpose of this retrospective study was to investigate the possible short-term benefit of a single intra-articular corticosteroid injection in those patients treated with physiotherapy when compared to a group of patients undergoing physiotherapy only (PT only). METHODS: A retrospective chart review was conducted to identify eligible patients treated over a 4-year period. All female patients between 40 years and 60 years with a confirmed clinical diagnosis of idiopathic adhesive capsulitis who completed a prescribed physiotherapy program were considered eligible...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28179618/increased-cortisol-and-cortisone-levels-in-overweight-children
#2
Lanling Chu, Kangwei Shen, Ping Liu, Kan Ye, Yu Wang, Chen Li, Xuejun Kang, Yuan Song
BACKGROUND It has been unclear whether relatively high cortisol and cortisone levels are related to overweight in childhood, parental body mass index (BMI), and family dietary habits. The aim of this study was to compare cortisol and cortisone levels in urine and saliva from overweight and normal children, as well as correlations between children's BMI, parental BMI and family dietary behavior questionnaire score (QS). MATERIAL AND METHODS We analyzed the data from 52 overweight children and 53 age- and sex-matched normal-weight children aged 4-5 years...
February 9, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28152550/novel-11%C3%AE-hydroxysteroid-dehydrogenase-1-inhibitors-reduce-cortisol-levels-in-keratinocytes-and-improve-dermal-collagen-content-in-human-ex-vivo-skin-after-exposure-to-cortisone-and-uv
#3
Stéphanie M Boudon, Anna Vuorinen, Piero Geotti-Bianchini, Eliane Wandeler, Denise V Kratschmar, Marc Heidl, Remo Campiche, Eileen Jackson, Alex Odermatt
Activity and selectivity assessment of new bi-aryl amide 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitors, prepared in a modular manner via Suzuki cross-coupling, are described. Several compounds inhibiting 11β-HSD1 at nanomolar concentrations were identified. Compounds 2b, 3e, 7b and 12e were shown to selectively inhibit 11β-HSD1 over 11β-HSD2, 17β-HSD1 and 17β-HSD2. These inhibitors also potently inhibited 11β-HSD1 activity in intact HEK-293 cells expressing the recombinant enzyme and in intact primary human keratinocytes expressing endogenous 11β-HSD1...
2017: PloS One
https://www.readbyqxmd.com/read/28152495/pancreatitis-panniculitis-and-polyarthritis-ppp-syndrome-caused-by-post-pancreatitis-pseudocyst-with-mesenteric-fistula-diagnosis-and-successful-surgical-treatment-case-report-and-review-of-literature
#4
Wulf Dieker, Johannes Derer, Thomas Henzler, Alexander Schneider, Felix Rückert, Torsten J Wilhelm, Bernd Krüger
INTRODUCTION: Pancreatitis, panniculitis and polyarthritis syndrome is a very rare extra-pancreatic complication of pancreatic diseases. PRESENTATION OF CASE: While in most cases this syndrome is caused by acute or chronic pancreatitis, we report a case of a 62-year-old man presenting with extensive intraosseous fat necrosis, polyarthritis and panniculitis caused by a post-pancreatitis pseudocyst with a fistula to the superior mesenteric vein and extremely high blood levels of lipase...
January 18, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28144768/variation-of-human-milk-glucocorticoids-over-24%C3%A2-hour-period
#5
Shikha Pundir, Clare R Wall, Cameron J Mitchell, Eric B Thorstensen, Ching T Lai, Donna T Geddes, David Cameron-Smith
Human milk (HM) contains a complex array of hormones, including members of the glucocorticoid family. The predominant glucocorticoids, cortisol and cortisone may influence the growth and behaviour of the breastfed infant. However, little is understood of the factors regulating the levels of these hormones within HM. The aim of the study was to examine HM cortisol and cortisone concentration, measured in samples collected at each feed during a 24 hour period. Twenty three exclusively breastfeeding mothers collected milk, prior to and after each breastfeeding session over 24 hour period at 3...
January 31, 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/28138053/progressive-perforation-of-the-nasal-septum-due-to-leishmania-major-a-case-of-mucosal-leishmaniasis-in-a-traveler
#6
Nicole Harrison, Julia Walochnik, Reinhard Ramsebner, Luzia Veletzky, Heimo Lagler, Michael Ramharter
This report describes a case of mucosal leishmaniasis caused by Leishmania major with destructive perforation of the nasal septum illustrating the diagnostic challenges of a rare clinical presentation of L. major infection in a traveler. The atypical presentation may have been associated with the use of cortisone as a potential trigger for the progressive destruction of the nasal septum.
January 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28132132/impaired-vascular-function-in-sarcoidosis-patients
#7
I Tuleta, D Skowasch, L Biener, C Pizarro, R Schueler, G Nickenig, N Schahab, C Schaefer, S Pingel
A common feature of sarcoidosis and atherosclerosis is a chronic systemic inflammatory reaction. Our hypothesis was that sarcoidosis may negatively influence the vessel status. We addressed the issue by examining preatherosclerotic vascular alternations using an ultrasound-based speckle-tracking method in 72 sarcoidosis patients and 15 matched controls. To find potential factors which may have a deleterious influence on arterial performance, different subgroups of sarcoidosis, such as sarcoidosis with or without cortisone therapy, pulmonary sarcoidosis in early and advanced stages, pulmonary sarcoidosis alone or combined with extrapulmonary sarcoidosis, and sarcoidosis with or without elevated blood levels of angiotensin converting enzyme (ACE)/soluble interleukin 2 receptor (sIL-2R) were investigated...
January 29, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28131073/maternal-salivary-cortisone-to-cortisol-ratio-in-late-pregnancy-an-improved-method-for-predicting-offspring-birth-weight
#8
Meredith Wilson, Zaneta Thayer
Overexposure to maternal cortisol in utero has been associated with lower birth weight of offspring. In order to regulate fetal exposure to this hormone, placental expression of 11-β-hydroxysteroid dehydrogenase-2, an enzyme that converts active cortisol to inactive cortisone, increases across pregnancy. Because of this increase in 11-βHSD2 activity, measuring maternal cortisol in isolation may not reflect actual fetal exposure to the hormone. Previous work by Hellgren et al. (2016) has shown that maternal serum cortisone:cortisol ratio was a better predictor of offspring birth weight than cortisol measured in isolation...
January 12, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28123438/a-rare-and-severe-complication-following-thyroid-fine-needle-aspiration-retropharyngeal-cellulitis
#9
Roberto Cesareo, Anda Naciu, Antonio Barberi, Valerio Pasqualini, Giuseppe Pelle, Silvia Manfrini, Gaia Tabacco, Angelo Lauria Pantano, Giuseppe Campagna, Roberto Cianni, Andrea Palermo
INTRODUCTION: Fine needle aspiration (FNA) is the most accurate and cost-effective method for evaluating thyroid nodules. We have reported a rare complication related to the procedure: severe retropharyngeal cellulitis. CASE PRESENTATION: A thirty-five-year-old female was admitted to hospital with hoarseness, laryngeal stridor and dyspnea without fever that emerged about 3 days after a first diagnostic FNA. After the procedure, the patient felt her voice became hoarse and 1 day before presentation began to have dyspnea, without fever...
October 2016: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28112069/placental-11-%C3%AE-hydroxysteroid-dehydrogenase-type-2-11%C3%AE-hsd2-expression-very-early-during-human-pregnancy
#10
K G Salvante, K Milano, H J Kliman, P A Nepomnaschy
Maternal physiologic stress during gestation has been reported to be associated with negative developmental outcomes, including intra-uterine growth restriction and reduced birth weight, which can impact postnatal development, behavior and health. The human fetus is partially protected from elevated cortisol exposure by placental 11 β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which oxidizes bioactive cortisol into bio-inactive cortisone. Importantly, despite the critical protective role hypothesized for 11β-HSD2, the onset of its placental expression has yet to be clearly established...
January 23, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28100283/genetic-influences-on-hormonal-markers-of-chronic-hypothalamic-pituitary-adrenal-function-in-human-hair
#11
E M Tucker-Drob, A D Grotzinger, D A Briley, L E Engelhardt, F D Mann, M Patterson, C Kirschbaum, E K Adam, J A Church, J L Tackett, K P Harden
BACKGROUND: Cortisol is the primary output of the hypothalamic-pituitary-adrenal (HPA) axis and is central to the biological stress response, with wide-ranging effects on psychiatric health. Despite well-studied biological pathways of glucocorticoid function, little attention has been paid to the role of genetic variation. Conventional salivary, urinary and serum measures are strongly influenced by diurnal variation and transient reactivity. Recently developed technology can be used to measure cortisol accumulation over several months in hair, thus indexing chronic HPA function...
January 19, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28043700/prenatal-di-2-ethylhexyl-phthalate-exposure-and-disruption-of-adrenal-androgens-and-glucocorticoids-levels-in-cord-blood-the-hokkaido-study
#12
Atsuko Araki, Takahiko Mitsui, Houman Goudarzi, Tamie Nakajima, Chihiro Miyashita, Sachiko Itoh, Seiko Sasaki, Kazutoshi Cho, Kimihiko Moriya, Nobuo Shinohara, Katsuya Nonomura, Reiko Kishi
Di(2-ethylhexyl) phthalate (DEHP) is known for its endocrine disrupting properties. We previously demonstrated that prenatal DEHP exposure is associated with decreased progesterone levels and testosterone/estradiol ratio in the cord blood. However, evidence of the effects of prenatal DEHP exposure on adrenal androgen and glucocorticoids in infants is scarce. Thus, the objectives of this study were to investigate the association between prenatal DEHP exposure and adrenal androgen and glucocorticoids, and to discuss its effects on steroid hormone profiles in infants...
December 30, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/28038491/some-social-aspects-of-discovery-synthesis-and-production-of-cortisone-in-the-1930s-1950s
#13
REVIEW
Daria Jadreškić
A discovery, synthesis and therapeutic application of cortisone present a paradigm for modern translational medicine (Hillier 2007, Saenger 2010), since they represented a joint achievement of discoveries by biochemists, Edward Calvin Kendall and Tadeus Reichstein; large scale synthesis by an industrial chemist, Lewis Hastings Sarett, and therapeutic application by a rheumatologist, Philip Showalter Hench. The goal of translational medicine is to speed up the process between basic research and clinical practice, and to integrate multiple disciplines in order to understand diverse outcomes (Zhang et al...
December 2016: Acta Medico-historica Adriatica: AMHA
https://www.readbyqxmd.com/read/27998757/intraindividual-stability-of-cortisol-and-cortisone-and-the-ratio-of-cortisol-to-cortisone-in-saliva-urine-and-hair
#14
Quan Zhang, Zheng Chen, Shenghuo Chen, Youyun Xu, Huihua Deng
BACKGROUND: Cortisol, cortisone and the ratio of cortisol to cortisone in saliva, urine and hair are acute, short-term and long-term biomarkers to reliably assess the activity of hypothalamic-pituitary-adrenal (HPA) axis and 11β-hydroxysteroid dehydrogenase (11β-HSD). One key issue is whether these biomarkers have intraindividual relative stability. Salivary, urinary and hair cortisol was proven to show considerable long-term intraindividual relative stability. However, currently unknown is whether cortisone and the ratio in saliva, urine and hair show intraindividual relative stability...
December 18, 2016: Steroids
https://www.readbyqxmd.com/read/27981314/severe-alveolar-hemorrhage-what-s-in-it-for-the-gastroenterologist
#15
Alina Popp, Ciprian Jurcuţ, Daniel Vasile Balaban, Mihai Șotcan, Kaija Laurila, Mariana Jinga
BACKGROUND: Alveolar hemorrhage is a potentially life-threatening condition which is usually managed by the pulmonologist. When considering its etiology, there is a rare association that sets the disease into the hands of the gastroenterologist. CASE PRESENTATION: We report the case of a 48 year-old female who was admitted to the intensive care unit for severe anemia and hemoptysis. On imaging, diffuse pulmonary infiltrates suggestive of alveolar hemorrhage were detected and a diagnosis of pulmonary hemosiderosis was made...
December 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/27973460/adrenal-disorders-and-nonalcoholic-fatty-liver-disease
#16
Labrini Papanastasiou, Stelios Fountoulakis, Ioannis A Vatalas
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the developed world and its pathogenesis is complex and multifactorial. It is considered the hepatic manifestation of the metabolic syndrome and is the leading cause of hepatic cirrhosis. This review aims to present current knowledge on the involvement of the adrenal glands in the development of NAFLD. Clinical and animal studies have shown that excess glucocorticoids (GC) have been implicated in the pathogenesis of NAFLD. Patients with NAFLD seem to have a subtle chronic activation of the hypothalamic pituitary adrenal axis leading to a state of subclinical hypercortisolism...
December 14, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27964706/low-dose-methotrexate-ld-mtx-in-rheumatology-practice-a-most-widely-misunderstood-drug
#17
REVIEW
Anand N Malaviya
Methotrexate (MTX) was synthesised as a folate antagonist for use in treating childhood leukaemia in 1940s. Gubner and colleagues in 1953 used several log-order lower doses of MTX that mimicked the anti-inflammatory properties of cortisone. They used it successfully in treating rheumatoid arthritis (RA). Their work was however overlooked because the Nobel Prize winning drug cortisone held sway in those days. With increasing awareness of the adverse effects of cortisone, interest was rekindled in discovering 'steroid-sparing' drugs...
2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27951607/-chronic-inflammatory-demyelinating-polyneuropathy
#18
M Balke, G Wunderlich, A Brunn, G R Fink, H C Lehmann
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a chronic progressive or relapsing autoimmune neuropathy with heterogeneous clinical presentation. Symptoms typically include symmetrical, proximal and/or distal paresis and sensory loss. Atypical CIDP variants are increasingly recognized, including subtypes with rapid onset as well as variants with pure sensory, focal or marked asymmetrical deficits. Diagnosis is established by compatible symptoms, characteristic electrophysiological features and cerebrospinal fluid analysis...
December 2016: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/27932530/affective-alterations-in-patients-with-cushing-s-syndrome-in-remission-are-associated-with-decreased-bdnf-and-cortisone-levels
#19
E Valassi, I Crespo, B G Keevil, A Aulinas, E Urgell, A Santos, P J Trainer, S M Webb
OBJECTIVE: Affective alterations and poorer quality of life often persist in patients with Cushing's syndrome (CS) in remission. Brain-derived neurotrophic factor (BDNF) regulates the hypothalamic-pituitary-adrenal axis (HPA) and is highly expressed in brain areas controlling mood and response to stress. Our aims were to assess affective alterations after long-term remission of CS and evaluate whether they are associated with serum BDNF, salivary cortisol (SalF) and/or cortisone (SalE) concentrations...
February 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27927697/absence-of-11-keto-reduction-of-cortisone-and-11-ketotestosterone-in-the-model-organism-zebrafish
#20
Maria Tsachaki, Arne Meyer, Benjamin Weger, Denise V Kratschmar, Janina Tokarz, Jerzy Adamski, Heinz-Georg Belting, Markus Affolter, Thomas Dickmeis, Alex Odermatt
Zebrafish are widely used as model organism. Their suitability for endocrine studies, drug screening and toxicity assessements depends on the extent of conservation of specific genes and biochemical pathways between zebrafish and human. Glucocorticoids consist of inactive 11-keto (cortisone, 11-dehydrocorticosterone) and active 11β-hydroxyl forms (cortisol, corticosterone). In mammals, two 11β-hydroxysteroid dehydrogenases (11β-HSD1, 11β-HSD2) interconvert active and inactive glucocorticoids, allowing tissue-specific regulation of glucocorticoid action...
December 7, 2016: Journal of Endocrinology
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