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https://www.readbyqxmd.com/read/29346086/the-dynamics-of-a-serum-steroid-profile-after-stimulation-with-intravenous-acth
#1
Johanna M Lindner, Anna Catharina Suhr, Stefanie H Grimm, Patrick Möhnle, Michael Vogeser, Josef Briegel
BACKGROUND: Stimulation with intravenous adrenocorticotropic hormone (ACTH) is a widely used diagnostic procedure to characterize the adrenocortical function. Currently, the response of serum cortisol, mainly quantified by immunoassays, is the only established read-out of this test. By using liquid chromatography coupled with mass spectrometry (LC-MS/MS) simultaneous determination of several steroids that respond to ACTH stimulation is now possible. The aim of this study was to further characterize the typical effect of exogenous ACTH (250 mg) on a LC-MS/MS-serum steroid profile...
December 26, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29340748/lack-of-level-i-evidence-on-how-to-prevent-infection-after-elective-shoulder-surgery
#2
Carola F Eck, Julie A Neumann, Orr Limpisvasti, Christopher R Adams
PURPOSE: Infection is a concern after all orthopedic procedures, including shoulder surgery. This systematic review of literature aimed to determine risk factors for infection as well as the availability and effectiveness of measures utilized to prevent infection after elective shoulder surgery. METHODS: An electronic database search was performed using MEDLINE (1950-October 2017), EMBASE (1980-October 2017), CINAHL (1982-October 2017), and the Cochrane database to identify studies reporting a risk factor or preventive measure for infection after shoulder surgery...
January 16, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29324461/efficacy-of-treatment-immune-thrombocytopenic-purpura-in-pregnancy-with-corticosteroids-and-intravenous-immunoglobulin-a-prospective-follow-up-of-suggested-practice
#3
Gisela Wegnelius, Katarina Bremme, Pelle G Lindqvist
: The current study is performed to assess a routine for treatment of immune thrombocytopenic purpura in pregnancy. A prospective programme for monitoring and treatment with intravenous immunoglobulin or cortisone in pregnancies with immune thrombocytopenic purpura was suggested to all delivery units in Sweden. Treatment should be avoided if platelet counts were more than 20 × 10/l during pregnancy with no bleeding complications and with a target of 100 × 10/l at delivery. Descriptive statistics and logistic regression analysis were used...
January 10, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29314170/pulsatility-of-glucocorticoid-hormones-in-pregnancy-changes-with-gestation-and-obesity
#4
Laura I Stirrat, Jamie J Walker, Ksenia Stryjakowska, Natalie Jones, Natalie Zm Homer, Ruth Andrew, Jane E Norman, Stafford L Lightman, Rebecca M Reynolds
OBJECTIVE: Hypothalamic-pituitary-adrenal-axis (HPA) activity is decreased in obese pregnancy and associates with increased fetal size. Pulsatile release of glucocorticoid hormones regulates their action in target tissues. Glucocorticoids are essential for normal fetal growth but little is known about glucocorticoid pulsatility in pregnancy. We aimed to investigate the ultradian rhythm of glucocorticoid secretion during obese and lean pregnancy and non-pregnancy. DESIGN: Serum cortisol, cortisone, corticosterone and 11-dehydrocorticosterone were measured by LC-MS/MS from samples obtained at 10-minute intervals between 08...
January 5, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29276600/atraumatic-bilateral-rupture-of-the-peroneus-brevis-tendon-in-recreational-sport-a-case-report
#5
Patric Scheidegger, Lukas Weisskopf, Anja Hirschmüller
Issue: Lower extremity tendon injuries often occur in physically active individuals. Most ruptures not involving great force are diagnosed in patients presenting underlying tendon degenerations. This also applies to patients taking medications because of a disease. We have observed several cases of bilateral Achilles tendon ruptures in patients who have been taking cortisone for a long period. We treated a healthy colleague (neurologist) in our clinic who sustained ruptures of the Achilles tendon on the left side (2012) and the peroneus brevis tendon on left side (2015) and right side (2016) after minimal traumata...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29248595/quantification-of-11b-hydroxysteroid-dehydrogenase-1-kinetics-and-pharmacodynamic-effects-of-inhibitors-in-brain-using-mass-spectrometry-imaging-and-stable-isotope-tracers-in-mice
#6
D F Cobice, D E W Livingstone, A McBride, C L MacKay, B R Walker, S P Webster, R Andrew
11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1; EC 1.1.1.146) generates active glucocorticoid hormones. Small molecule inhibitors have been developed to target 11β-HSD1 for the treatment of dementia; these must enter brain subregions, such as the hippocampus, to be effective. We previously reported mass spectrometry imaging measurement of murine tissue steroids, and deuterated steroid tracer infusion quantification of 11 β -HSD1 turnover in humans. Here, these tools are combined to assess tissue pharmacokinetics and pharmacodynamics of an 11 β -HSD1 inhibitor that accesses the brain...
December 14, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29244855/vitreous-hyper-reflective-dots-in-pseudophakic-cystoid-macular-edema-assessed-with-optical-coherence-tomography
#7
Wilfried Glatz, Gernot Steinwender, Lisa Tarmann, Eva Maria Malle, Marlene Schörkhuber, Werner Wackernagel, Goran Petrovski, Andreas Wedrich, Domagoj Ivastinovic
PURPOSE: This study compares the presence of vitreous hyper-reflective dots (VHDs) detected with optical coherence tomography (OCT) between eyes with pseudophakic cystoid macular edema (CME) and those with no CME after cataract surgery. In addition, we evaluated the impact of VHDs on the responsiveness of pseudophakic CME to cortisone treatment. SETTING: Department of Ophthalmology, Medical University of Graz, Austria. DESIGN: Retrospective, monocenter case-controlled study...
2017: PloS One
https://www.readbyqxmd.com/read/29235050/copeptin-and-insulin-resistance-effect-modification-by-age-and-11-%C3%AE-hsd2-activity-in-a-population-based-study
#8
S Canivell, M Mohaupt, D Ackermann, M Pruijm, I Guessous, G Ehret, G Escher, A Pechère-Bertschi, B Vogt, O Devuyst, M Burnier, P-Y Martin, B Ponte, M Bochud
PURPOSE: Arginine vasopressin (AVP) may be involved in metabolic syndrome (MetS) by altering liver glycogenolysis, insulin and glucagon secretion, and pituitary ACTH release. Moreover, AVP stimulates the expression of 11β-hydroxysteroid-dehydrogenase-type 2 (11β-HSD2) in mineralocorticosteroid cells. We explored whether apparent 11β-HSD2 activity, estimated using urinary cortisol-to-cortisone ratio, modulates the association between plasma copeptin, as AVP surrogate, and insulin resistance/MetS in the general adult population...
December 12, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29234678/follow-up-measurement-of-corrected-qt-interval-in-adult-patients-before-and-after-lung-transplantation
#9
Dirk Bandorski, Reinhard Hoeltgen, Nicole Becker, Winfried Padberg, Harilaos Bogossian, Christoph Wiedenroth, Matthias Arlt, Christian Hamm, Werner Seeger, Hossein Ardeschir Ghofrani, Matthias Hecker, Henning Gall, Konstantin Mayer
Background: Prolongation of the corrected QT (QTc) interval is well known for many drugs, some of which are an integral part of the therapeutic regimen after lung transplantation (LTX). Therefore, we investigated the QTc interval after LTX in the present study. Patients and Methods: The medical records of patients after LTX were studied for demographic data, indication of LTX, medication, and baseline and follow-up ECGs. The QT interval was corrected for the patient's heart rate using the different formulae of Bazett, Fridericia, Hodges, and Framingham...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29221568/nutritional-programming-by-glucocorticoids-in-breast-milk-targets-mechanisms-and-possible-implications
#10
REVIEW
Jonneke J Hollanders, Annemieke C Heijboer, Bibian van der Voorn, Joost Rotteveel, Martijn J J Finken
Vertical transmission of glucocorticoids via breast milk might pose a mechanism through which lactating women could prepare their infants for the postnatal environment. The primary source of breast-milk glucocorticoids is probably the systemic circulation. Research from our group showed that milk cortisol and cortisone concentrations follow the diurnal rhythm of maternal hypothalamus-pituitary-adrenal axis activity, with a higher abundance of cortisone compared to cortisol. Measurement of breast-milk glucocorticoid concentrations is challenging due to possible cross-reactivity with progestagens and sex steroids, which are severely elevated during pregnancy and after parturition...
August 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29221204/11%C3%AE-hsd1-inhibition-ameliorates-diabetes-induced-cardiomyocyte-hypertrophy-and-cardiac-fibrosis-through-modulation-of-egfr-activity
#11
Chunpeng Zou, Weixin Li, Yong Pan, Zia A Khan, Jieli Li, Xixi Wu, Yi Wang, Liancheng Deng, Guang Liang, Yunjie Zhao
11β-HSD1 has been recognized as a potential therapeutic target for type 2 diabetes. Recent studies have shown that hyperglycemia leads to activation of 11β-HSD1, increasing the intracellular glucocorticoid levels. Excess glucocorticoids may lead to the clinical manifestations of cardiac injury. Therefore, the aim of this study is to investigate whether 11β-HSD1 activation contributes to the development of diabetic cardiomyopathy. To investigate the role of 11β-HSD1, we administered a selective 11β-HSD1 inhibitor in type 1 and type 2 murine models of diabetes and in cultured cardiomyocytes...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220883/association-of-adrenal-hormone-metabolites-and-mortality-over-a-6-year-follow-up-in-copd-patients-with-acute-exacerbation
#12
Seline Zurfluh, Manuela Nickler, Manuel Ottiger, Christian Steuer, Alexander Kutz, Mirjam Christ-Crain, Werner Zimmerli, Robert Thomann, Claus Hoess, Christoph Henzen, Luca Bernasconi, Andreas Huber, Beat Mueller, Philipp Schuetz
BACKGROUND: The release of hormones from the adrenal gland is vital in acute and chronic illnesses such as chronic obstructive pulmonary disease (COPD) involving recurrent exacerbations. Using a metabolomic approach, we aim to investigate associations of different adrenal hormone metabolites with short- and long-term mortality in COPD patients. METHODS: We prospectively followed 172 COPD patients (median age 75 years, 62% male) from a previous Swiss multicenter trial...
December 7, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29215552/two-distinct-clinical-courses-of-human-cowpox-germany-2015
#13
Ines Eder, Patrick Vollmar, Martin Pfeffer, Philipp Naether, Arne Christian Rodloff, Hermann Meyer
Here we present two cases of human infection with cowpox virus with distinct clinical courses. A series of clinical photographs documents lesion progression over time. In the first case-an unvaccinated young veterinary assistant-a pustule was treated locally with cortisone. The lesion turned into a large ulcer accompanied by severe lymphadenitis. Based on her close contact to a sick stray cat, infection with cowpox virus was assumed and confirmed by virus isolation, PCR, and serology. The clinical course took up to eleven months until healing of the wound was complete...
December 7, 2017: Viruses
https://www.readbyqxmd.com/read/29206210/immortalization-of-porcine-11%C3%AE-hydroxysteroid-dehydrogenase-type-1-transgenic-liver-cells-using-sv40-large-t-antigen
#14
Hee Young Kang, Young-Kwon Choi, Yeon Ik Jeong, Kyung-Chul Choi, Sang-Hwan Hyun, Woo-Suk Hwang, Eui-Bae Jeung
Cortisol is a steroid hormone essential to the maintenance of homeostasis that is released in response to stress and low blood glucose concentration. Cortisol is converted from cortisone by 11βhydroxysteroid dehydrogenase type 1 (HSD11B1). It has been reported that too much cortisol or overexpression of HSD11B1 induces obesity and the insulin resistance that accompanies metabolic syndrome in rodent adipose tissue. In our previous study, HSD11B1-transgenic (TG) fibroblasts were established, and a porcine model was generated by SCNT using those fibroblasts...
December 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29203512/glucocorticoids-reprogram-beta-cell-signaling-to-preserve-insulin-secretion
#15
Nicholas H F Fine, Craig L Doig, Yasir S Elhassan, Nicholas C Vierra, Piero Marchetti, Marco Bugliani, Rita Nano, Lorenzo Piemonti, Guy A Rutter, David A Jacobson, Gareth G Lavery, David J Hodson
Excessive glucocorticoid exposure has been shown to be deleterious for pancreatic beta cell function and insulin release. However, glucocorticoids at physiological levels are essential for many homeostatic processes, including glycemic control. Here, we show that corticosterone and cortisol and their less active precursors, 11-dehydrocorticosterone (11-DHC) and cortisone, suppress voltage-dependent Ca2+ channel function and Ca2+ fluxes in rodent as well as human beta cells. However, insulin secretion, maximal ATP/ADP responses to glucose and beta cell identity were all unaffected...
December 4, 2017: Diabetes
https://www.readbyqxmd.com/read/29202560/the-use-of-hyaluronic-acid-in-the-treatment-of-shoulder-capsulitis-a-systematic-review
#16
R Papalia, A Tecame, G Vadalà, F Russo, M Perna, G Papalia, F Bressi, S Sterzi, V Denaro
Adhesive capsulitis (AC) is a common pathological condition of the shoulder characterized by painful restriction of range of motion (ROM) of the glenohumeral joint. Currently, no consensus has been reached regarding the best treatment. Hyaluronic acid (HA) injection is a safe procedure that can result in significant improvement in active and passive ROM, alleviating pain and improving shoulder function. We systematically reviewed current literature in order to evaluate the best evidence about the effectiveness of intra-articular HA injection for the treatment of primary AC...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29199242/a-single-step-breeding-generated-a-diagnostic-anti-cortisol-antibody-fragment-with-over-30-fold-enhanced-affinity
#17
Hiroyuki Oyama, Izumi Morita, Yuki Kiguchi, Tomomi Morishita, Sakiko Fukushima, Yuki Nishimori, Toshifumi Niwa, Norihiro Kobayashi
Cortisol levels in bodily fluids represent a useful index for pituitary-adrenal function, and thus practical anti-cortisol antibodies are required. We have studied "antibody-breeding" approaches, which involve in vitro evolution of antibodies to improve their antigen-binding performances. Here, we produced an antibody fragment to measure serum cortisol levels with over 30-fold enhanced affinity after single mutagenesis and selection steps. A mouse anti-cortisol antibody, Ab-CS#3, with insufficient affinity for practical use, was chosen as the prototype antibody...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29194043/the-role-of-corticosteroid-binding-globulin-in-the-evaluation-of-adrenal-insufficiency
#18
REVIEW
Kate C Verbeeten, Alexandra H Ahmet
Cortisol is a hydrophobic molecule that is largely bound to corticosteroid-binding globulin (CBG) in the circulation. In the assessment of adrenal insufficiency, many clinicians measure a total serum cortisol level, which assumes that CBG is present in normal concentrations and with a normal binding affinity for cortisol. CBG concentration and affinity are affected by a number of common factors including oral contraceptive pills (OCPs), fever and infection, as well as rare mutations in the serine protease inhibitor A6 (SERPINA6) gene, and as such, total cortisol levels might not be the ideal way to assess adrenal function in all clinical circumstances...
December 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29191827/proteasome-mediated-degradation-of-collagen-iii-by-cortisol-in-amnion-fibroblasts
#19
Yabing Mi, Wangsheng Wang, Jiangwen Lu, Chuyue Zhang, Yawei Wang, Hao Ying, Kang Sun
Rupture of fetal membranes (ROM) can initiate parturition at both term and preterm. Collagen III in the compact layer of the amnion contributes to the tensile strength of fetal membranes. However, the upstream signals triggering collagen III degradation remain mostly elusive. In this study we investigated the role of cortisol regenerated by 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in collagen III degradation in human amnion fibroblasts with an aim to seek novel targets for the prevention of preterm premature ROM (PPROM)-elicited preterm birth...
November 30, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29191401/comparative-profiling-of-adrenal-steroids-in-maternal-and-umbilical-cord-blood
#20
Simon Travers, Laetitia Martinerie, Pascal Boileau, Qiong-Yao Xue, Marc Lombès, Eric Pussard
Fetal steroidome in late pregnancy receives multiple contributions from both maternal and fetal adrenals as well as from placenta. Depressed glucocorticoid levels have been reported in fetal blood at birth, yet studies on mineralocorticoid pathways are sparse. To investigate biosynthesis pathways at birth, adrenal steroids profiles were established in paired mothers and neonates. Forty-six paired healthy term newborns and their mothers from the Aldo cohort were assessed. Steroidomic profiles of mineralocorticoids, glucocorticoids and adrenal androgens were established from umbilical cord and maternal blood at birth using a highly sensitive and specific LC-MS/MS methodology...
November 27, 2017: Journal of Steroid Biochemistry and Molecular Biology
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