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https://www.readbyqxmd.com/read/29778832/glucocorticoid-metabolites-in-newborns-a-marker-for-traffic-noise-related-stress
#1
Manuella Lech Cantuaria, Jakob Usemann, Elena Proietti, Victoria Blanes-Vidal, Bernhard Dick, Christa E Flück, Simone Rüedi, Harris Héritier, Jean-Marc Wunderli, Philipp Latzin, Urs Frey, Martin Röösli, Danielle Vienneau
BACKGROUND: Traffic noise has been associated with an increased risk for several non-auditory health effects, which may be explained by a noise-induced release of stress hormones (e.g. glucocorticoids). Although several studies in children and adults have indicated an increased secretion of glucocorticoids after exposure to noise, information regarding newborns is scarce. OBJECTIVES: To investigate the association between residential exposure to road traffic noise and postnatal stress response, as assessed by the concentration of glucocorticoids at five weeks of age...
May 17, 2018: Environment International
https://www.readbyqxmd.com/read/29770837/systematic-investigations-of-endogenous-cortisol-and-cortisone-in-nails-by-lc-ms-ms-and-correlation-to-hair
#2
Tina M Binz, Franziska Gaehler, Clarissa D Voegel, Mathias Hofmann, Markus R Baumgartner, Thomas Kraemer
Hair samples are increasingly used for measuring the long-term stress mediator cortisol. However, hair is not always available and nails (finger or toe), as a keratinized matrix, may be an alternative to hair. In order to measure cortisol and cortisone in the nail matrix, an LC-MS/MS method has been developed and validated using 13 C3 -labeled surrogate analytes. Both analytes were measured in ESI negative mode as formic acid adducts. Different sample preparation techniques were assessed, and single-step extraction in methanol was established for determination of cortisone and cortisol in the nail matrix...
May 17, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29762444/efficacy-of-autologous-platelet-concentrates-as-adjuvant-therapy-to-surgical-excision-in-the-treatment-of-keloid-scars-refractory-to-conventional-treatments-a-pilot-prospective-study
#3
Barbara Hersant, Mounia SidAhmed-Mezi, Frédéric Picard, Oana Hermeziu, Anne-Marie Rodriguez, Khaled Ezzedine, Jean Paul Meningaud
BACKGROUND: After conventional treatments, keloid scars show varying degrees of recurrence. The aim of this study was to assess the efficacy and safety of platelet-rich plasma in the treatment of postoperative keloid scars refractory to conventional treatments. METHODS: This pilot prospective study was conducted in 17 patients with keloid scars who did not respond to 4 injections of cortisone or radiotherapy after extralesional resection of keloid. Platelet-rich plasma was injected intraoperatively and then 3 times with a 1-month interval...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29753148/sex-related-differences-in-the-associations-between-maternal-dioxin-like-compounds-and-reproductive-and-steroid-hormones-in-cord-blood-the-hokkaido-study
#4
Chihiro Miyashita, Atsuko Araki, Takahiko Mitsui, Sachiko Itoh, Houman Goudarzi, Seiko Sasaki, Jumboku Kajiwara, Tsuguhide Hori, Kazutoshi Cho, Kimihiko Moriya, Nobuo Shinohara, Katsuya Nonomura, Reiko Kishi
BACKGROUND: Prenatal exposure to dioxin-like compounds (DLCs) irreversibly affects fetal reproductive and steroid hormone synthesis. OBJECTIVE: This study aimed to assess the relationships between maternal DLCs and cord blood reproductive and steroid hormones. METHODS: Participants in this study were pregnant women who enrolled in the Sapporo Cohort of the Hokkaido Study between 2002 and 2005. We quantified 29 DLCs during the 2nd and 3rd trimesters in maternal blood...
May 9, 2018: Environment International
https://www.readbyqxmd.com/read/29739493/the-treatment-of-primary-arthritis-of-the-finger-and-thumb-joint
#5
Christian Karl Spies, Martin Langer, Peter Hahn, Lars Peter Müller, Frank Unglaub
BACKGROUND: Primary finger and thumb joint arthritis is common, with a markedly rising prevalence from age 50 onward. As the population as a whole ages, the need for effective, stage-appropriate treatment of this condition is increasing. METHODS: This review is based on pertinent publications retrieved by a selective search in the PubMed and Cochrane Library databases. RESULTS: Pain on movement and morning stiffness are commonly reported symptoms...
April 20, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29738970/a-novel-derivatives-of-thiazol-4-5h-one-and-their-activity-in-the-inhibition-of-11%C3%AE-hydroxysteroid-dehydrogenase-type-1
#6
Renata Studzińska, Renata Kołodziejska, Daria Kupczyk, Wojciech Płaziński, Tomasz Kosmalski
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is an enzyme that catalyzes the conversion of inactive cortisone into physiologically active cortisol. Inhibiting the activity of this enzyme plays a key role in the treatment of Cushing's syndrome, metabolic syndrome and type 2 diabetes. Therefore, new compounds that are selective inhibitors of this enzyme are constantly being looked for. In this work we present the synthesis of 2-(allylamino)thiazol-4(5H)-one derivatives by the reaction of N-allylthiourea with appropriate α-bromoesters...
April 30, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29721436/overexpression-of-11%C3%AE-hydroxysteroid-dehydrogenase-1-in-visceral-adipose-tissue-and-underexpression-of-endothelial-nitric-oxide-synthase-in-the-adrenal-cortex-of-dogs-with-hyperadrenocorticism
#7
Diego Daniel Miceli, Adriana María Belén Abiuso, Patricia Noemi Vidal, María Florencia Gallelli, Omar Pedro Pignataro, Victor Alejandro Castillo
11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) is an enzyme that activates cortisone into cortisol in tissues. Alterations in this enzyme are related to the development of metabolic syndrome, obesity and hyperadrenocorticism (HAC). Endothelial nitric oxide synthase (eNOS) produces nitric oxide and is related to the regulation of adrenal steroidogenesis. The aim of the study was to evaluate 11β-HSD1 and eNOS expression in dogs with HAC. Visceral adipose tissue samples were taken to evaluate 11β-HSD1 expression by immunohistochemistry and western blotting...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29720109/altered-cerebral-glucose-metabolism-normalized-in-a-patient-with-a-pediatric-autoimmune-neuropsychiatric-disorder-after-streptococcal-infection-pandas-like-condition-following-treatment-with-plasmapheresis-a-case-report
#8
A H Nave, P Harmel, R Buchert, L Harms
BACKGROUND: Pediatric autoimmune neuropsychiatric disorder after streptococcal infection (PANDAS) is a specific autoimmune response to group-A streptococcal infections in children and adolescents with a sudden onset of obsessive-compulsive disorders or tic-like symptoms. Cerebral metabolic changes of patients have not yet been observed. CASE PRESENTATION: We present a case of an 18-year old male with a PANDAS-like condition after developing tic-like symptoms and involuntary movements three weeks after cardiac surgery...
May 2, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29717618/glucocorticoid-signaling-enhances-expression-of-glucose-sensing-molecules-in-immature-pancreatic-beta-like-cells-derived-from-murine-embryonic-stem-cells-in-vitro
#9
Nadiah Ghazalli, Xiaoxing Wu, Stephanie Walker, Nancy Trieu, Li-Yu Hsin, Justin Choe, Chialin Chen, Jasper Hsu, Jeanne LeBon, Mark T Kozlowski, Jeffrey Rawson, David A Tirrell, M L Richard Yip, Hsun Teresa Ku
Pluripotent stem cells may serve as an alternative source of beta-like cells for replacement therapy of type 1 diabetes; however, the beta-like cells generated in many differentiation protocols are immature. The maturation of endogenous beta cells involves an increase in insulin expression starting in late gestation and a gradual acquisition of the abilities to sense glucose and secrete insulin by week 2 after birth in mice; however, what molecules regulate these maturation processes are incompletely known...
May 2, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29702999/immunological-markers-as-predictors-of-developing-steroid-induced-diabetes-mellitus-in-pemphigus-vulgaris-patients-an-observational-study
#10
Ana Sorina Dănescu, Ioana Bâldea, Daniel Corneliu Leucuţa, Iulia Lupan, Gabriel Samaşca, Cassian Sitaru, Roxana Chiorean, Adrian Baican
The aim of this study was to evaluate the clinical importance of autoantibodies in pemphigus vulgaris patients who developed steroid-induced diabetes mellitus (SID) because of the glucocorticoid therapy of pemphigus.A total of 137 patients with pemphigus vulgaris were studied. Patients with SID and pemphigus were compared with those that had only pemphigus. The variables recorded were: age at diagnosis, sex, body mass index, presence of diabetes mellitus (DM), cumulative cortisone dose, treatment duration, value of anti-desmoglein 1 and 3, and anti-glutamic acid decarboxylase autoantibodies...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29679067/psychological-stress-deteriorates-skin-barrier-function-by-activating-11%C3%AE-hydroxysteroid-dehydrogenase-1-and-the-hpa-axis
#11
Sung Jay Choe, Donghye Kim, Eun Jung Kim, Joung-Sook Ahn, Eun-Jeong Choi, Eui Dong Son, Tae Ryong Lee, Eung Ho Choi
Psychological stress (PS) increases endogenous glucocorticoids (GC) by activating the hypothalamic-pituitary-adrenal axis. The negative effects of GC on skin barrier function under PS have been well-established. However, endogenous GC can also be active when cortisone (inactive form) is converted to cortisol (active form) by 11β-hydroxysteroid dehydrogenase type I (11ß-HSD1) in the peripheral tissue. Here, we evaluated the changes in 11ß-HSD1 and barrier function under PS. Elevated 11ß-HSD1 in oral mucosa correlated with increased cortisol in the stratum corneum and deteriorated barrier function...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674401/licorice-induced-apparent-mineralocorticoid-excess-compounded-by-excessive-use-of-terbutaline-and-high-water-intake
#12
Laust Frisenberg Buhl, Frederik Nørregaard Pedersen, Marianne Skovsager Andersen, Dorte Glintborg
This case highlights the clinical course of a 54-year-old male patient presenting with hypertension and long-term refractory hypokalaemia. He reported long-term malaise, fatigue and physical discomfort. Diarrhoea, vomiting, over-the-counter drugs, dietary supplements and any kind of medical abuse were all denied. Physical examination was normal. Suppressed plasma renin activity along with a low aldosterone level and elevated urinary cortisone/cortisol metabolite excretion ratio raised the suspicion of apparent mineralocorticoid excess (AME)...
April 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29674169/intergenerational-gene-%C3%A3-environment-interaction-of-fkbp5-and-childhood-maltreatment-on-hair-steroids
#13
Alexandra M Koenig, Laura Ramo-Fernández, Christina Boeck, Maria Umlauft, Markus Pauly, Elisabeth B Binder, Clemens Kirschbaum, Harald Gündel, Alexander Karabatsiakis, Iris-Tatjana Kolassa
BACKGROUND: The inconsistency in results of cortisol alterations after childhood maltreatment (CM) might arise due to the fact that no study so far considered the effects of environmental factors such as maltreatment load and genetic factors such as the influence of FKBP5 genotype on stress hormone regulation. This study analyzed the interaction between the single nucleotide polymorphism rs1360780 within the FKBP5 gene and the severity of maternal CM experiences (maltreatment load) on hair steroid levels of mother-infant-dyads...
April 5, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29668337/reduced-longitudinal-cardiac-strain-in-asthma-patients
#14
I Tuleta, N Eckstein, F Aurich, G Nickenig, C Schaefer, D Skowasch, R Schueler
OBJECTIVE: There is limited knowledge about the potential relationship between asthma and heart function. Aim of our present study was to examine if asthma may be associated with manifest or subclinical heart dysfunction. METHODS: 72 allergic mild-to-moderate and severe asthma patients and 20 matched controls were enrolled in the study. Depending on the anti-asthmatic therapy, four subgroups of asthma patients were created: patients under long-acting beta2-agonists (LABA) and inhaled cortisone without oral cortisone treatment with (1a) versus without (1b) additional omalizumab therapy; patients with LABA, inhaled cortisone and omalizumab treatment with (2a) versus without (2b) oral cortisone...
April 18, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29627396/characterization-of-circulating-steroid-hormone-profiles-in-the-bottlenose-dolphin-tursiops-truncatus-by-liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms
#15
Thomas M Galligan, Lori H Schwacke, Dorian S Houser, Randall S Wells, Teri Rowles, Ashley S P Boggs
Systemic steroid hormone measurements are often used in the assessment of reproductive, developmental, and stress physiology in vertebrates. In protected wildlife, such as the common bottlenose dolphin (Tursiops truncatus), these measures can provide critical information about health and fitness to aid in effective conservation and management. Circulating steroid hormone concentrations are typically measured by immunoassays, which have imperfect specificity and are limited to the measurement of a single hormone per assay...
April 5, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29624785/relationship-between-adrenal-steroid-hormones-in-cord-blood-and-birth-weight-the-sapporo-cohort-hokkaido-study-on-environment-and-children-s-health
#16
Takahiko Mitsui, Atsuko Araki, Houman Goudarzi, Chihiro Miyashita, Sachiko Ito, Seiko Sasaki, Takeya Kitta, Kimihiko Moriya, Kazutoshi Cho, Keita Morioka, Reiko Kishi, Nobuo Shinohara, Masayuki Takeda, Katsuya Nonomura
OBJECTIVES: We investigated the relationship between steroid hormone levels in cord blood and birth weight. METHODS: Among 514 participants in a prospective birth cohort study in Sapporo, the following hormone levels were measured in 294 stored cord blood samples from 135 males and 159 females: androstenedione, dehydroepiandrosterone (DHEA), cortisol, and cortisone. Birth weight information was obtained from medical records. RESULTS: Androstenedione/DHEA was significantly higher in males than in females, while DHEA was significantly higher in females...
April 6, 2018: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29618067/local-cortisol-elevation-contributes-to-endometrial-insulin-resistance-in-polycystic-ovary-syndrome
#17
Jia Qi, Wangsheng Wang, Qinling Zhu, Yaqiong He, Yao Lu, Yuan Wang, Xiaoxue Li, Zi-Jiang Chen, Yun Sun
Context: Endometrial insulin resistance may account for the endometrial dysfunction in polycystic ovary syndrome (PCOS). The underlying mechanism remains to be elucidated. Objective: To investigate whether the abundance of 11β-hydroxysteroid dehydrogenases (11β-HSD1 and -2) and cortisol as well as the insulin signaling pathway are altered in PCOS endometrium and to clarify the relationship between endometrial insulin resistance (IR) and local cortisol. Design: We measured cortisol and cortisone concentrations, 11β-HSD1 and -2, and core insulin signaling molecules in endometrial biopsies collected from non-PCOS and PCOS with or without IR patients on day hCG+7...
March 30, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29617893/serum-cortisol-and-cortisone-as-potential-biomarkers-of-partial-11%C3%AE-hydroxysteroid-dehydrogenase-type-2-deficiency
#18
Cristian A Carvajal, Alejandra Tapia-Castillo, Carolina P Valdivia, Fidel Allende, Sandra Solari, Carlos F Lagos, Carmen Campino, Alejandro Martínez-Aguayo, Andrea Vecchiola, Constanza Pinochet, Claudia Godoy, Virginia Iturrieta, Rene Baudrand, Carlos E Fardella
Background: Pathogenic variations in HSD11B2 gene triggers the apparent mineralocorticoid excess syndrome (AME). There is scarce information regarding the phenotypes of subjects carrying heterozygous pathogenic variants in HSD11B2 gene. We investigated if serum cortisol/cortisone(F/E) ratio and cortisone are useful for identifying partial 11βHSD2 deficiency in those heterozygous subjects. Methods: We studied two patients diagnosed with AME and their families carrying either D223N or R213C mutation...
March 30, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29611097/increased-cortisol-metabolism-in-women-with-pregnancy-related-hypertension
#19
Katarzyna Kosicka, Anna Siemiątkowska, Agata Szpera-Goździewicz, Mariola Krzyścin, Grzegorz H Bręborowicz, Franciszek K Główka
PURPOSE: The diminished function of 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2) was found in placentae from preeclamptic pregnancies. Here, we examine the overall maternal glucocorticoid balance in pregnancy-related hypertension. We aim to answer the question if the functions of primary enzymes involved in cortisol metabolism: 11β-HSD1 and 11β-HSD2 and 5-reductases (both 5α- and 5β) are altered in the course of hypertensive pregnancy. METHODS: We determined plasma and urinary cortisol and cortisone as well as their urinary tetrahydro- and allo-tetrahydrometabolites, both in free and conjugated forms in samples obtained from 181 Polish women in the third trimester of pregnancy...
April 2, 2018: Endocrine
https://www.readbyqxmd.com/read/29604496/side-chain-removal-from-corticosteroids-by-unspecific-peroxygenase
#20
René Ullrich, Marzena Poraj-Kobielska, Steffi Scholze, Claire Halbout, Martin Sandvoss, Marek J Pecyna, Katrin Scheibner, Martin Hofrichter
Two unspecific peroxygenases (UPO, EC 1.11.2.1) from the basidiomycetous fungi Marasmius rotula and Marasmius wettsteinii oxidized steroids with hydroxyacetyl and hydroxyl functionalities at C17 - such as cortisone, Reichstein's substance S and prednisone - via stepwise oxygenation and final fission of the side chain. The sequential oxidation started with the hydroxylation of the terminal carbon (C21) leading to a stable geminal alcohol (e.g. cortisone 21-gem-diol) and proceeded via a second oxygenation resulting in the corresponding α-ketocarboxylic acid (e...
March 26, 2018: Journal of Inorganic Biochemistry
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