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https://www.readbyqxmd.com/read/28801958/virtual-reality-jogging-as-a-novel-exposure-paradigm-for-the-acute-urge-to-be-physically-active-in-patients-with-eating-disorders-implications-for-treatment
#1
Georgios Paslakis, Vanessa Fauck, Kathrin Röder, Elisabeth Rauh, Manfred Rauh, Yesim Erim
The acute urge to be physically active is a relevant clinical phenomenon in patients suffering from eating disorders. In this study with n = 20 female patients with anorexia nervosa and n = 10 female patients with bulimia nervosa, a virtual reality (VR) jogging paradigm was applied as a novel highly immersive 3-D exposure paradigm. Patients were asked to rate their acute urge to be physically active during the exposure procedure. A 10-item self-report questionnaire (smQ) was developed to capture the cognitive, emotional, and behavioral aspects of the acute urge to move...
August 11, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28798699/schizophrenia-or-atypical-lupus-erythematosus-with-predominant-psychiatric-manifestations-over-25%C3%A2-years-case-analysis-and-review
#2
Axel Mack, Christiane Pfeiffer, E Marion Schneider, Karl Bechter
We observed a case over 25 years of relapsing-remitting schizophrenic spectrum disorder, varying regarding the main symptomatology between more depressive or more schizoaffective or rather typical schizophrenic syndrome. Diseased phases were repeatedly accompanied by minor skin lesions, which were initially classified as mixed tissue disorder. Psychotic phases were waxing-waning over years. During one later relapse, skin involvement was severe, classified to likely represent an allergic reaction to psychopharmaca; this generalized exanthema remitted rapidly with cortisone treatment and azathioprine...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28797028/characterisation-of-the-cancer-associated-glucocorticoid-system-key-role-of-11%C3%AE-hydroxysteroid-dehydrogenase-type-2
#3
Nicola Cirillo, David J Morgan, Maria Carmela Pedicillo, Antonio Celentano, Lorenzo Lo Muzio, Michael J McCullough, Stephen S Prime
BACKGROUND: Recent studies have shown that production of cortisol not only takes place in several non-adrenal peripheral tissues such as epithelial cells but, also, the local inter-conversion between cortisone and cortisol is regulated by the 11β-hydroxysteroid dehydrogenases (11β-HSDs). However, little is known about the activity of this non-adrenal glucocorticoid system in cancers. METHODS: The presence of a functioning glucocorticoid system was assessed in human skin squamous cell carcinoma (SCC) and melanoma and further, in 16 epithelial cell lines from 8 different tissue types using ELISA, western blotting and immunofluorescence...
August 10, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28793178/ultraviolet-and-infrared-induced-11-beta-hydroxysteroid-dehydrogenase-type-1-activating-skin-photoaging-is-inhibited-by-red-ginseng-extract-containing-high-concentrations-of-ginsenoside-rg3-s
#4
Jin-Ju Nam, Ji-Eun Min, Min-Ho Son, Jin-Hwan Oh, Seunghyun Kang
BACKGROUND: Sun irradiation is one of major extrinsic stressors responsible for premature skin aging through activation and expression of 11 beta hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts inactive cortisone to active cortisol. The aim of this study was to evaluate the inhibitory effects of red ginseng extract containing high concentrations of ginsenoside Rg3(S) (GERg3) on 11β-HSD1-induced skin photoaging. METHODS: To evaluate the inhibitory effects of GERg3 on ultraviolet (UV) or infrared (IR)-induced skin photoaging, human dermal fibroblasts or a normal human 3D skin model were exposed to UV or an IR...
August 9, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28781093/hair-cortisol-as-a-biological-marker-for-burnout-symptomatology
#5
Marlene Penz, Tobias Stalder, Robert Miller, Vera M Ludwig, Magdalena K Kanthak, Clemens Kirschbaum
Burnout is a syndrome with negative impact on cognitive performance and mood as a consequence of long-term stress at work. It is further associated with increased risk for mental and physical diseases. One potential pathway to mediate chronic work-stress and adverse health conditions in burnout is through alterations in long-term glucocorticoid secretion. Here, we present cross-sectional data on hair cortisol/cortisone (hairF/hairE) concentrations and burnout from a population-based sample of the Dresden Burnout Study (DBS; N=314 hair samples)...
July 23, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28780517/mitotane-effects-on-the-hypothalamic-pituitary-adrenal-axis-in-patients-with-adrenocortical-carcinoma
#6
Giuseppe Reimondo, Soraya Puglisi, Barbara Zaggia, Vittoria Basile, Laura Saba, Paola Perotti, Silvia De Francia, Marco Volante, Maria Chiara Zatelli, Salvatore Cannavò, M Terzolo
OBJECTIVE: Mitotane, a drug used to treat adrenocortical cancer (ACC), inhibits multiple enzymatic steps of adrenocortical steroid biosynthesis, potentially causing adrenal insufficiency. Recent studies in vitro have also documented a direct inhibitory effect of mitotane at the pituitary level. The present study was aimed to assess the hypothalamic pituitary adrenal axis in ACC patients receiving mitotane. DESIGN AND METHODS: We prospectively enrolled 16 patients on adjuvant treatment with mitotane after radical surgical resection of ACC, who underwent standard hormone evaluation and h-CRH stimulation...
August 5, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28771488/maternal-obesity-programs-reduced-leptin-signaling-in-the-pituitary-and-altered-gh-igf1-axis-function-leading-to-increased-adiposity-in-adult-sheep-offspring
#7
Nuermaimaiti Tuersunjiang, John F Odhiambo, Desiree R Shasa, Ashley M Smith, Peter W Nathanielsz, Stephen P Ford
Studies in rodents highlight a role for leptin in stimulation of pituitary growth hormone (GH) secretion, with an impact on body composition regulation. We have reported that maternal obesity (MO) during ovine pregnancy results in hyperphagia, glucose-insulin dysregulation, increased adiposity, hypercortisolemia and hyperleptinemia in mature offspring subjected to a bout of ad libitum feeding. We hypothesized that MO reduces leptin signaling in the pituitary and down regulates the GH/IGF1 axis and increases circulating cortisol leading to increased adiposity in their adult offspring...
2017: PloS One
https://www.readbyqxmd.com/read/28769874/high-glucocorticoid-response-to-24-h-shift-stressors-in-male-but-not-in-female-physicians
#8
Claudia Boettcher, Michaela F Hartmann, Klaus-Peter Zimmer, Stefan A Wudy
Physicians' daily work is accompanied by emotional and physical stress, and 24-h shifts are considered to be a major stressor. Effects of stressors on the hypothalamic-pituitary-adrenal (HPA) axis can be evaluated by estimating the glucocorticoid excretion in urine samples. We characterized the impact of a 24-h working period on the urinary glucocorticoid excretion of physicians and focused on gender differences. 10 females and 12 male physicians collected 24-h urine samples during a 24-h shift ("on-duty") and on a free weekend ("off-duty") that were analyzed by gas chromatography-mass spectrometry...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28765040/the-cortisol-activating-enzyme-11%C3%AE-hydroxysteroid-dehydrogenase-type-1-in-skeletal-muscle-in-the-pathogenesis-of-the-metabolic-syndrome
#9
REVIEW
Christine Loerz, Edmund Maser
The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) contributes to intracellular glucocorticoid action by converting inactive cortisone to its receptor-active form cortisol (11-dehydrocorticosterone and corticosterone in mice and rats). The potential role of 11β-HSD1 in the pathogenesis of the metabolic syndrome has emerged over the past three decades. However, the precise impact of 11β-HSD1 in obesity-related diseases remains uncertain. Many studies from animal experiments to clinical studies have investigated liver and adipose tissue 11β-HSD1 in relation to obesity and its metabolic disorders including insulin resistance...
July 29, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28759940/impact-of-aldosterone-synthase-inhibitor-fad286-on-steroid-hormone-profile-in-human-adrenocortical-cells
#10
Coy Brunssen, Anja Hofmann, Mirko Peitzsch, Annika Frenzel, Christian G Ziegler, Nicholas F Brown, Steven M Weldon, Graeme Eisenhofer, Holger S Willenberg, Stefan R Bornstein, Henning Morawietz
Inhibition of aldosterone synthase (CYP11B2) is an alternative treatment option to mineralocorticoid receptor antagonism to prevent harmful aldosterone effects. FAD286 is the best characterized aldosterone synthase inhibitor. However, to date, no study has used sensitive liquid chromatography-tandem mass spectrometry to characterize in detail the effect of FAD286 on the secreted steroid hormone profile of adrenocortical cells. Basal aldosterone production in NCI-H295R cells was detectable and 9-fold elevated after stimulation with angiotensin II...
July 31, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28758623/risk-factors-and-predictors-of-carbapenem-resistant-pseudomonas-aeruginosa-and-acinetobacter-baumannii-mortality-in-critically-ill-bacteraemic-patients-over-a-6-year-period-2010-15-antibiotics-do-matter
#11
Matthaios Papadimitriou-Olivgeris, Fotini Fligou, Anastasia Spiliopoulou, Kyriaki Koutsileou, Fevronia Kolonitsiou, Aikaterini Spyropoulou, Anastasia Zotou, Markos Marangos, Evangelos D Anastassiou, Myrto Christofidou, Iris Spiliopoulou
PURPOSE: Acinetobacter baumannii and Pseudomonas aeruginosa provoke serious infections, especially in intensive care unit (ICU) patients. METHODOLOGY: The risk factors and predictors of mortality for P. aeruginosa (n=84; 46 carbapenem-resistant) and A. baumannii (n=129; all carbapenem-resistant) bloodstream infections (BSIs) in an ICU were evaluated. Antibiotic susceptibility testing was performed using the agar disk diffusion method according to EUCAST guidelines...
July 31, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28755555/determination-of-endogenous-and-exogenous-corticosteroids-in-bovine-urine-and-effect-of-fighting-stress-during-the-batailles-des-reines-on-their-biosynthesis
#12
Marta Leporati, Maria Nobile, Pierluigi Capra, Eugenio Alladio, Marco Vincenti
Natural corticosteroids include two families of substances: mineralocorticoids and glucocorticoids. Several drugs of similar structure and biological activity have been synthesized and are currently used in the clinical practice. Beside legal pharmacological treatments, these drugs have been consistently misused in animal breeding. One of the most abused corticosteroids is prednisolone. For many years, prednisolone has been considered of exclusive synthetic origin, but nowadays a debate about its possible endogenous production is under way...
July 4, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28752602/alterations-in-the-steroid-biosynthetic-pathways-in-the-human-prefrontal-cortex-in-mood-disorders-a-postmortem-study
#13
Xin-Rui Qi, Sabina Luchetti, Ronald W H Verwer, Arja A Sluiter, Matthew R J Mason, Jiang-Ning Zhou, Dick F Swaab
Altered levels of steroids have been reported in the brain, cerebral spinal fluid and plasma of patients with mood disorders. Neuroimaging studies have reported both functional and structural alterations in mood disorders, for instance in the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC). In order to determine whether the endogenous production of steroids is altered in the ACC and DLPFC of patients with major depressive disorder (MDD) or bipolar disorder (BPD), quantitative real-time PCR was performed to detect mRNA expression level of key enzymes in the steroid biosynthetic pathways...
July 27, 2017: Brain Pathology
https://www.readbyqxmd.com/read/28750217/association-of-hsd11b1-gene-polymorphisms-with-type-2-diabetes-and-metabolic-syndrome-in-south-indian-population
#14
Nayana Devang, Kapaettu Satyamoorthy, Padmalatha S Rai, M Nandini, Satish Rao, Nagaraja M Phani, Prabha Adhikari
BACKGROUND: 11beta-hydroxysteroid dehydrogenase Type 1 (11β-HSD1) is an NADP or NADPH-dependent enzyme that generates cortisol from cortisone for a local glucocorticoid action. Functional polymorphisms within 11beta-hydroxysteroid dehydrogenase Type 1 (HSD11B1) gene have shown an association with various factors, including insulin resistance (IR) and hypertension. In our study, we have assessed the association of HSD11B1 (rs12086634 and rs846910) gene polymorphisms with type 2 diabetes (T2D) and metabolic syndrome (metS)...
July 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28735224/simultaneous-quantification-of-cortisol-and-cortisone-in-urines-from-infants-with-packed-fiber-solid-phase-extraction-coupled-to-hplc-ms-ms
#15
Chen Li, Zhao Zhang, Xiongwei Liu, Kangwei Shen, Pan Gu, Xuejun Kang
Cortisol and cortisone are two important glucocorticoids in human body, their interconversion is controlled by two isotypes of 11β-hydroxy steroid dehydrogenase (11β-HSD1 and 11β-HSD2). The ratio of urinary cortisol to cortisone can be used to assess the activity of 11β-HSDs. An analytical method to quantify urinary cortisol and cortisone using high performance liquid chromatographic tandem mass spectrometry following a packed-fiber solid-phase extraction (PFSPE) was developed. The proposed method was validated and applied to determine the urinary cortisol and cortisone concentrations in infants...
July 12, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28720554/is-there-an-association-between-cortisol-and-hypertension-in-overweight-or-obese-children
#16
Aleid Jg Wirix, Martijn Jj Finken, Ines A Von Rosenstiel-Jadoul, Annemieke C Heijboer, Jeroen Nauta, Jaap W Groothoff, Mai Jm Chinapaw, Joana E Kist-Van Holthe
OBJECTIVE: The precise mechanisms behind the development of hypertension in overweight or obese children are not yet completely understood. Alterations in hypothalamus-pituitary-adrenal axis activity may play a role. We aimed to investigate if there is an association between cortisol parameters and hypertension in overweight or obese children. METHODS: Random urine (n=180) and early-morning saliva samples (n=126) for assessment of cortisol and cortisone were collected from 1) hypertensive overweight children (n=50); 2) normotensive overweight children (n=145) and 3) normotensive non-overweight children (n=75)...
July 17, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28719982/deep-friction-massage-versus-steroid-injection-in-the-treatment-of-lateral-epicondylitis
#17
Rosemary Yi, Walter W Bratchenko, Virak Tan
BACKGROUND: The aim of the study was to determine the efficacy of deep friction massage in the treatment of lateral epicondylitis by comparing outcomes with a control group treated with splinting and therapy and with an experimental group receiving a local steroid injection. METHODS: A randomized clinical trial was conducted to compare outcomes after recruitment of consecutive patients presenting with lateral epicondylitis. Patients were randomized to receive one of 3 treatments: group 1: splinting and stretching, group 2: a cortisone injection, or group 3: a lidocaine injection with deep friction massage...
February 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28691975/stability-of-cortisol-and-cortisone-in-human-breast-milk-during-holder-pasteurization
#18
Bibian van der Voorn, Marita de Waard, Lisette R Dijkstra, Annemieke C Heijboer, Joost Rotteveel, Johannes B van Goudoever, Martijn J J Finken
Human donor milk is the feeding of choice for preterm infants, when own mother's milk is not available. Holder pasteurization is necessary to secure the safety of donor milk, although it can affect milk quality by reduction of nutritional and bioactive components. Recently, research has focused on the potential role of breast-milk glucocorticoids for infant development. At this moment, it is unknown whether pasteurization affects milk glucocorticoid levels. Therefore, we assessed whether Holder pasteurization, the most frequently used method nowadays, reduces breast-milk cortisol and cortisone levels, using breast milk samples from 30 women who delivered at term...
July 6, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28690388/-23-na-mri-and-myometry-to-compare-eplerenone-vs-glucocorticoid-treatment-in-duchenne-dystrophy
#19
Philip A Glemser, Heike Jaeger, Armin M Nagel, Andreas E Ziegler, David Simons, Heinz-Peter Schlemmer, Frank Lehmann-Horn, Karin Jurkat-Rott, Marc-André Weber
In this pilot study we tested whether a low dose application of a mild diuretic substance such as eplerenone is beneficial in early stages of Duchenne muscular dystrophy using (23)Na und (1)H imaging, myometry, and clinical testing versus the glucocorticoid gold standard. Two 7-years old patients with DMD were examined on a 3T MRI system. (1)H MRI and (23)Na density-adapted 3-dimensional radial MRI sequences were performed both before and 1, 3 and 6 months after therapy with eplerenone respectively cortisone...
March 2017: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
https://www.readbyqxmd.com/read/28680378/effects-of-cellular-11%C3%AE-hydroxysteroid-dehydrogenase-1-on-lps-induced-inflammatory-responses-in-synovial-cell-line-sw982
#20
Young Sik Cho, Ki Nam Kim, Jung Hyun Shim
11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) catalyzes the conversion of inactive cortisone into active cortisol, which has pleiotropic roles in various biological conditions, such as immunological and metabolic homeostasis. Cortisol is mainly produced in the adrenal gland, but can be locally regenerated in the liver, fat, and muscle. Its diverse actions are primarily mediated by binding to the glucocorticoid receptor. SW982, a human synovial cell line, expresses 11β-HSD type 1, but not type 2, that catalyzes the conversion of cortisone to cortisol...
June 2017: Immune Network
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