keyword
MENU ▼
Read by QxMD icon Read
search

Cortisone

keyword
https://www.readbyqxmd.com/read/28525786/steroid-bioaccumulation-profiles-in-typical-freshwater-aquaculture-environments-of-south-china-and-their-human-health-risks-via-fish-consumption
#1
Shan Liu, Xiang-Rong Xu, Zhan-Hui Qi, Hui Chen, Qin-Wei Hao, Yong-Xia Hu, Jian-Liang Zhao, Guang-Guo Ying
More attention was previously paid to adverse effects of steroids on aquatic organisms and their ecological risks to the aquatic environment. So far, little information has been reported on the bioaccumulative characteristics of different classes of steroids in cultured fish tissues. The present study for the first time provided a comprehensive analysis of the occurrence, bioaccumulation, and global consumers' health risks via fish consumption of androgens, glucocorticoids and progestanges in typical freshwater cultured farms in South China...
May 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28523515/distribution-of-exogenous-and-endogenous-cyp3a-markers-and-related-factors-in-healthy-males-and-females
#2
Jieon Lee, Andrew HyoungJin Kim, SoJeong Yi, SeungHwan Lee, Seo Hyun Yoon, Kyung-Sang Yu, In-Jin Jang, Joo-Youn Cho
Cytochrome P450 (CYP) 3A is an important drug-metabolizing enzyme in humans. Assessing CYP3A activity is necessary for predicting therapeutic outcomes or the potential adverse events of various therapeutics. This study sought to evaluate the distribution of endogenous and exogenous markers reflecting hepatic CYP3A activity and related factors affecting its activity in healthy male and female. Each subject was given a single 1 mg dose of midazolam intravenously. Pharmacokinetics, pharmacometabolomics, and pharmacogenomics analyses were performed to evaluate CYP3A activity...
May 18, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28505491/development-of-suitable-method-for-large-scale-urinary-glucocorticoid-analysis-by-liquid-chromatography-mass-spectrometry
#3
Akiko Matsumoto, Chisato Shimanoe, Keitaro Tanaka, Masayoshi Ichiba, Megumi Hara
Levels of urinary glucocorticoids and their concentration ratios have been analyzed as potential markers for various pathological statuses. Large-scale studies may possibly accelerate the investigations; however, a suitable method needs to be established. Analytical conditions for measurement of urinary glucocorticoids with LCMS were examined. Electrospray ionization in the positive ion mode was applied for detection of cortisol (precursor>product ion: 363.3>121.0), cortisol-d4 (internal standard, IS, 367...
July 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28499151/biphenyl-based-stationary-phases-for-improved-selectivity-in-complex-steroid-assays
#4
Johanna M Lindner, Michael Vogeser, Stefanie H Grimm
The measurement of steroid hormones and their corticoid precursors is an important aspect in endocrinology since these analytes are biomarkers for several endocrine disorders. Over the last few years, HPLC-MS/MS has become the method of choice to analyze these compounds. There are already several methods using stationary phases modified with C18 groups. However, since these columns sometimes do not enable sufficient separation of some isobaric steroids, we investigated the potential of a different RP modification using biphenyl groups for the separation of challenging isobars such as corticosterone, 11- and 21-deoxycortisol...
April 19, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28479316/reference-intervals-for-plasma-concentrations-of-adrenal-steroids-measured-by-lc-ms-ms-impact-of-gender-age-oral-contraceptives-body-mass-index-and-blood-pressure-status
#5
Graeme Eisenhofer, Mirko Peitzsch, Denise Kaden, Katharina Langton, Christina Pamporaki, Jimmy Masjkur, George Tsatsaronis, Anastasios Mangelis, Tracy A Williams, Martin Reincke, Jacques W M Lenders, Stefan R Bornstein
BACKGROUND: Mass spectrometric-based measurements of the steroid metabolome have been introduced to diagnose disorders featuring abnormal steroidogenesis. Defined reference intervals are important for interpreting such data. METHODS: Liquid chromatography-tandem mass spectrometry was used to establish reference intervals for 16 steroids (pregnenolone, progesterone, 11-deoxycorticosterone, corticosterone, aldosterone, 18-oxocortisol, 18-hydroxycortisol, 17-hydroxyprogesterone, 21-deoxycortisol, 11-deoxycortisol, cortisol, cortisone, dehydroepiandrosterone, dehydroepiandrosterone-sulfate, androstenedione, testosterone) measured in plasma from 525 volunteers with (n=227) and without (n=298) hypertension, including 68 women on oral contraceptives...
May 4, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28479185/neuroimaging-of-takayasu-arteritis-in-a-patient-with-ulcerative-rectocolitis
#6
Lucia Monti, Rosamaria Servillo, Irene Grazzini, Leila Khader, Maurizio Acampa, Alfonso Cerase
BACKGROUND: Takayasu arteritis (TA), also known as aortoarteritis and pulseless disease, is an autoimmune, idiopathic, large-vessel vasculitis that primarily affects the aorta and its major branches, the coronary arteries, and the pulmonary arteries. METHODS: This is a peculiar clinical and radiological pattern of TA in a young female Caucasian. Her medical history included diagnosis of ulcerative rectocolitis at the age of 14. Because of the occurrence of anemia and exacerbation of rectocolitis, she had started infliximab associated with low doses of cortisone and mesalazine...
May 4, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28461837/a-case-of-sweet-s-syndrome-secondary-to-myelodysplastic-syndrome-diagnostic-and-treatment-challenges
#7
Sfrijan Doinita, Visan Simina-Maria, Diaconu Bianca, Zurac Sabina, Scurtu Cristian
Sweet's Syndrome also knows as acute febrile neutrophilic dermatosis, is a rare skin's condition, that can occur either idiopathic or secondary. In the case of the latter, the syndrome can develop after certain malignancies (paraneoplastic syndrome), because of exposure to some medication or post infectious. It is more frequent in women aged between 30 and 50 years, but concerning children, the disorder is extremely rare (8% of the total number of cases), having equal sex ratio distribution. We present the case of an 11 year old male, diagnosed with systemic form of SS associated with Myelodysplastic Syndrome...
June 2016: Mædica
https://www.readbyqxmd.com/read/28457967/dhrs7-sdr34c1-a-new-player-in-the-regulation-of-androgen-receptor-function-by-inactivation-of-5%C3%AE-dihydrotestosterone
#8
Selene Araya, Denise V Kratschmar, Maria Tsachaki, Simon Stücheli, Katharina R Beck, Alex Odermatt
DHRS7 (SDR34C1) has been associated with potential tumor suppressor effects in prostate cancer; however, its function remains largely unknown. Recent experiments using purified recombinant human DHRS7 suggested several potential substrates, including the steroids cortisone and Δ4-androstene-3,17-dione (androstenedione). However, the substrate and cofactor concentrations used in these experiments were very high and the physiological relevance of these observations needed to be further investigated. In the present study, recombinant human DHRS7 was expressed in intact HEK-293 cells in order to investigate whether glucocorticoids and androgens serve as substrates at sub-micromolar concentrations and at physiological cofactor concentrations...
April 27, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28451456/immunosuppressive-treatment-in-fulminant-myocarditis-and-gene-expression-pattern-associated-with-but-no-histological-confirmation-of-giant-cell-myocarditis
#9
Friedrich Fruhwald, Dirk Lassner, Sonja Fruhwald, Ulrich M Gross, Otto Dapunt, Heinz-Peter Schultheiss
A healthy woman with acute onset of pulmonary oedema and severely depressed left ventricular function underwent endomyocardial biopsy under the clinical suspicion of fulminant myocarditis. While awaiting the results of biopsy, the situation deteriorated to Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) and extracorporeal membrane oxygenation was implanted. Finally, immunohistochemistry in biopsy specimen corresponded to fulminant lymphocytic myocarditis, although active myocarditis was excluded...
May 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28435101/interaction-of-glucocorticoids-and-progesterone-derivatives-with-human-serum-albumin
#10
Rola Abboud, Mohammad Akil, Catherine Charcosset, Hélène Greige-Gerges
Glucocorticoids (GCs) and progesterone derivatives (PGDs) are steroid hormones with well-known biological activities. Their interaction with human serum albumin (HSA) may control their distribution. Their binding to albumin is poorly studied in literature. This paper deals with the interaction of a series of GCs (cortisol, cortisone, prednisolone, prednisone, 6-methylprednisolone and 9-fluorocortisol acetate) and PGDs (progesterone, hydroxylated PGDs, methylated PGDs and dydrogesterone) with HSA solution (pH 7...
April 20, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28419184/mechanisms-for-the-species-difference-between-mouse-and-pig-oocytes-in-their-sensitivity-to-glucorticoids%C3%A2
#11
Shuai Gong, Guang-Yi Sun, Min Zhang, Hong-Jie Yuan, Shuai Zhu, Guang-Zhong Jiao, Ming-Jiu Luo, Jing-He Tan
Although in vitro exposure to physiological concentrations of glucorticoids did not affect maturation of mouse oocytes, it significantly inhibited nuclear maturation of pig oocytes. Studies on this species difference in oocyte sensitivity to glucocorticoids will contribute to our understanding of how stress/glucocorticoids affect oocytes. This study showed that glucorticoid receptors (NR3C1) were expressed in both oocytes and cumulus cells (CCs) of both pigs and mice; however, while cortisol inhibition of oocyte maturation was overcome by NR3C1 inhibitor RU486 in pigs, it could not be relieved by RU486 in mice...
April 17, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28417588/a-scalable-and-versatile-synthesis-of-oxime-based-hormone-dimers-and-gels-for-sustained-release
#12
Christopher W Bennett, Joe Collins, Zeyun Xiao, Daniel Klinger, Luke A Connal
Well-defined steroid hormone dimers and organogels were produced via a facile and scalable synthesis using oxime click chemistry. The versatile synthetic procedure extends to a wide range of hormones and linker groups exemplified here through the synthesis of cortisol- and progesterone-dimers linked via hydrophobic, hydrophilic or functional groups. This method was also extended to the synthesis of cortisone-based organogels. Owing to the dynamic nature of the oxime bond, the hormone-based materials are degradable via acidic hydrolysis and transoximination representing new materials for the controlled release of steroid hormones...
April 18, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28415914/sealing-of-the-round-and-oval-window-niches-with-triamcinolone-soaked-fascia-as-salvage-surgical-therapy-in-sudden-sensorineural-hearing-loss
#13
Benjamin Loader, Rudolf Seemann, Claudia Atteneder, Elisabeth Sterrer, Peter Franz, Claudia Lill
CONCLUSIONS: Triamcinolone-soaked fascia seems to show better hearing improvement when added to tympanotomy for sudden idiopathic sensorineural hearing loss (SSHL), compared to fascia round window occlusion without triamcinolone. OBJECTIVES: To analyse if adding triamcinolone to sealing the round and oval window niches with fascia results in improved audiological outcome for acute SNHL. METHODS: Fifty-three patients (27m:43 ± 12 years, 26f:45 ± 14 years) with acute SSHL ≥50dB over 3 frequencies, who failed primary therapy, underwent transcanal tympanotomy...
April 18, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28407311/biological-variability-in-serum-cortisol-concentration-post-adrenocorticotropic-hormone-stimulation-in-healthy-dogs
#14
A Gal, K Weidgraaf, J P Bowden, N Lopez-Villalobos, N J Cave, J P Chambers, F Castillo-Alcala
BACKGROUND: The ACTH stimulation has low sensitivity for the diagnosis of hypercortisolism possibly as a result of biological and analytical variability. HYPOTHESIS/OBJECTIVES: To report the components of biological and analytical variability in serum cortisol concentration post-ACTH stimulation ([cortisol]) in healthy dogs. ANIMALS: Fourteen healthy harrier hound dogs. METHODS: The data were extracted from a separate, prospective, randomized, double-blinded, controlled discovery study in which dogs treated with vehicle control and 4 different doses of cortisone acetate (CA) for 7 days had an ACTH stimulation test performed to confirm the dose-dependent effect of CA...
May 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28398098/mapk-signaling-has-stage-dependent-osteogenic-effects-on-human-adipose-derived-stem-cells-in-vitro
#15
Eric J Tsang, Benjamin Wu, Patricia Zuk
OVERVIEW: The use of pro-osteogenic growth factors, such as BMP2, in human adipose-derived stem cell (ASC) osteogenesis is well described. Because these growth factors work via signal transduction pathways, such as the mitogen-activated protein kinase (MAPK) cascade, a study of the relationship between MAPK signaling and ASC osteogenesis was conducted. MATERIALS AND METHODS: ERK, JNK, and p38MAPK activation were measured in ASCs osteo-induced using either dexamethasone or vitamin D3 and correlated with mineralization...
April 11, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28375882/salivary-cortisol-and-cortisone-in-the-clinical-setting
#16
Joanne Blair, Jo Adaway, Brian Keevil, Richard Ross
PURPOSE OF REVIEW: A resurgence of interest in salivary biomarkers has generated evidence for their value in assessing adrenal function. The advantages of salivary measurements include only free hormone is detected, samples can be collected during normal daily routines and stress-induced cortisol release is less likely to occur than during venepuncture. We review the use of salivary biomarkers to diagnose and monitor patients for conditions of cortisol excess and deficiency and discuss the value of measuring salivary cortisone versus salivary cortisol...
June 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28373267/longitudinal-analyses-of-the-steroid-metabolome-in-obese-pcos-girls-with-weight-loss
#17
Thomas Reinehr, Alexandra Kulle, Juliane Rothermel, Caroline Knop-Schmenn, Nina Lass, Christina Bosse, Paul-Martin Holterhus
OBJECTIVE: The underlying mechanisms of polycystic ovarian syndrome (PCOS) are not fully understood yet. The aim of the study was to get functional insights into the regulation of steroid hormones in PCOS by steroid metabolomics. DESIGN: This is a longitudinal study of changes of steroid hormones in 40 obese girls aged 13-16 years (50% with PCOS) participating in a 1-year lifestyle intervention. Girls with and without PCOS were matched to age, BMI and change of weight status...
May 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28366868/recent-advances-in-the-study-of-11%C3%AE-hydroxysteroid-dehydrogenase-type-2-11%C3%AE-hsd2-inhibitors
#18
REVIEW
Chunchun Zhou, Fan Ye, He Wu, Hui Ye, Quanxu Chen
11β-Hydroxysteroid dehydrogenase (11β-HSD), which interconverts hormonally active cortisol and inactive cortisone in multiple human tissues, has two distinct isoforms named 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) and 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2). 11β-HSD2 is an NAD(+)-dependent oxidase which lowers cortisol by converting it to cortisone while 11β-HSD1 mainly catalyzes the reduction which converts cortisone into cortisol. Selective inhibition of 11β-HSD2 is generally detrimental to health because the accumulation of cortisol can cause metabolic symptoms such as apparent mineralocorticoid excess (AME), fetal developmental defects and lower testosterone levels in males...
March 21, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28365516/charged-derivatization-and-on-line-solid-phase-extraction-to-measure-extremely-low-cortisol-and-cortisone-levels-in-human-saliva-with-liquid-chromatography-tandem-mass-spectrometry
#19
Balázs Magda, Zoltán Dobi, Katalin Mészáros, Éva Szabó, Zoltán Márta, Tímea Imre, Pál T Szabó
The aim of this study was to develop a sensitive, reliable and high-throughput liquid chromatography - electrospray ionization - mass spectrometric (LC-ESI-MS/MS) method for the simultaneous quantitation of cortisol and cortisone in human saliva. Derivatization with 2-hydrazino-1-methylpyridine (HMP) was one of the most challenging aspects of the method development. The reagent was reacting with cortisol and cortisone at 60°C within 1h, giving mono- and bis-hydrazone derivatives. Investigation of derivatization reaction and sample preparation was detailed and discussed...
June 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28363270/hip-pain-dry-needling-versus-cortisone-injections
#20
(no author information available yet)
Greater trochanteric pain syndrome (GTPS) is chronic, intermittent pain and tenderness on the outside of the hip. The medical community once thought that a swollen hip bursa was the source of such pain, which led to the use of corticosteroid injections to the bursa to help decrease swelling and pain. However, researchers now believe that injuries to the muscles and tendons around the hip are the actual cause of this pain, and that inflammation is often not involved. A study published in the April 2017 issue of JOSPT explores dry needling as an alternative to cortisone injections to reduce pain and improve function in patients with GTPS...
April 2017: Journal of Orthopaedic and Sports Physical Therapy
keyword
keyword
5347
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"