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https://www.readbyqxmd.com/read/27856655/glucocorticoids-and-chronic-inflammation
#1
REVIEW
Rainer H Straub, Maurizio Cutolo
Glucocorticoids are steroid hormones that once bound to their receptor interact with the DNA binding domain. Almost 1000-2000 genes are sensitive to their effects, including immune/inflammatory response genes. However, their role in pathophysiology and therapy is still debated. We performed a literature survey using the key words glucocorticoids, inflammation, autoimmune disease, rheumatology and adrenal glands in order to define important targets for this review on glucocorticoids. Considering endogenous/exogenous glucocorticoids in chronic inflammatory diseases brought up five major points for discussion: inadequately low production of endogenous cortisol relative to systemic inflammation (the disproportion principle); changes of the systemic and local cortisol-to-cortisone shuttle (reactivation and degradation of cortisol); inflammation-induced glucocorticoid resistance; highlights of present glucocorticoid therapy; and the role of circadian rhythms in action of cortisol...
December 2016: Rheumatology
https://www.readbyqxmd.com/read/27855510/uhplc-ms-ms-bioanalysis-of-urinary-dhea-cortisone-and-their-hydroxylated-metabolites-as-potential-biomarkers-for-cyp3a-mediated-drug-drug-interactions
#2
Naiyu Zheng, Lisa J Christopher, Xuewen Ma, Qin C Ji, Adela Buzescu, Hamza Kandoussi, Samira M Garonzik, Frank LaCreta, Anne-Francoise Aubry, Mark E Arnold, Jianing Zeng
AIM: A UHPLC-MS/MS assay was developed to quantify urinary dehydroepiandrosterone (DHEA), 7β-hydroxy-DHEA, cortisone and 6β-hydroxycortisone as potential biomarkers to predict CYP3A activity. RESULTS: A sensitive assay at LLOQ of 0.500 ng/ml with good accuracy and precision was developed for the four analytes in human urine. This UHPLC-MS/MS assay was optimized by eliminating nonspecific loss of the analytes in urine, ensuring complete hydrolysis of the conjugates to unconjugated forms and use of the product ions of [M+H-H2O](+) for multiple reaction monitoring detection of DHEA and 7β-hydroxy-DHEA...
December 2016: Bioanalysis
https://www.readbyqxmd.com/read/27848093/a-new-technique-for-promoting-cyclic-utilization-of-cyclodextrins-in-biotransformation
#3
Yanbing Shen, Ziqi Yu, Xu Yang, Fang Wang, Jianmei Luo, Min Wang
Cyclodextrins (CDs) can improve the productivity of steroid biotransformation by enhancing substrate solubility. CDs can be recycled by grafting them with appropriate carriers. Loofah fiber is an excellent grafting material for CDs, and can be applied to the biotransformation and recycling of β-cyclodextrin (β-CD). In this work, a technique for recycling β-CD in cortisone acetate (CA) biotransformation by Arthrobacter simplex CPCC 140451 was studied. Loofah fiber-grafted β-CD (LF-β-CD) was prepared using epichlorohydrin, which is a cross-linking agent...
November 15, 2016: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27813051/salivary-cortisol-and-cortisone-do-not-appear-to-be-useful-biomarkers-for-monitoring-hydrocortisone-replacement-in-addison-s-disease
#4
I L Ross, M Lacerda, T S Pillay, D J Blom, G Johannsson, J A Dave, N S Levitt, D Haarburger, J-S van der Walt
Salivary cortisol has been used to monitor hydrocortisone replacement in patients with Addison's disease (AD). Since salivary cortisol is metabolised to salivary cortisone, it may be an adjunctive analyte to assess adequacy of hydrocortisone replacement in patients with AD. We aimed to characterise the exposure of salivary cortisol and cortisone in patients and healthy controls. We measured salivary cortisol and cortisone by liquid chromatography-tandem mass spectrometry and constructed a day curve (08:00 until 24:00 h) with 16 time points in 25 AD patients taking their usual hydrocortisone dose and in 26 healthy controls...
November 3, 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27774663/liver-and-serum-expression-of-matrix-metalloproteinases-in-asymptomatic-pediatric-liver-transplant-recipients
#5
Silja H Voutilainen, Silja K Kosola, Taina I Tervahartiala, Timo A Sorsa, Hannu J Jalanko, Mikko P Pakarinen
BACKGROUND: We related hepatic gene and serum expression of matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) to liver histology in pediatric LT recipients. METHODS: Liver biopsies and serum samples were obtained from 52 patients 10.6 years post-LT and age-matched controls for analyses of MMPs and TIMPs. RESULTS: Patients with fibrosis had significantly higher hepatic gene expression of MMP-2, MMP-9, MMP-14, TIMP-1 and TIMP-2 than patients without...
October 23, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27715400/genetic-variation-in-the-11%C3%AE-hydroxysteroid-dehydrogenase-1-gene-determines-nafld-and-visceral-obesity
#6
Stefan Z Lutz, Andreas Peter, Fausto Machicao, Apostolia Lamprinou, Jürgen Machann, Fritz Schick, Ingmar Königsrainer, Alfred Königsrainer, Andreas Fritsche, Harald Staiger, Hans-Ulrich Häring, Norbert Stefan, Konstantinos Kantartzis
CONTEXT/OBJECTIVE: Acute pharmacological inhibition of 11β-hydroxysteroid-dehydrogenase 1 (11β-HSD1), which converts cortisone into the much more potent cortisol in peripheral tissues, results in reduction of total-, visceral- and liver fat, but not of insulin resistance. We now investigated whether lifelong alterations of 11β-HSD1 activity similarly affect these cardiometabolic risk parameters, by studying single nucleotide polymorphisms (SNPs) in the 11β-HSD1-coding gene (HSD11B1)...
October 7, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27682404/simultaneous-determination-of-seven-neuroactive-steroids-associated-with-depression-in-rat-plasma-and-brain-by-high-performance-liquid-chromatography-tandem-mass-spectrometry
#7
Youqiong Wang, Lipeng Tang, Wei Yin, Jiesi Chen, Tiandong Leng, Xiaoke Zheng, Wenbo Zhu, Haipeng Zhang, Pengxin Qiu, Xiaoxiao Yang, Guangmei Yan, Haiyan Hu
Sensitive and specific biomarkers are required for the diagnosis and treatment of depression because the existing diagnostic criteria are subjective and could produce false positives or negatives. Some endogenous neuroactive steroids that have shown either antidepressant effects or concentration changes in individuals with depression could provide potential biomarkers. In this study, a simple and specific method was developed to simultaneously determine seven endogenous neuroactive steroids in biological samples: cortisone, cortisol, dehydroepiandrosterone, estradiol, progesterone, pregnenolone, and testosterone...
2016: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/27646492/impact-of-maternal-steroids-during-pregnancy
#8
Rebecca M Reynolds
Increased fetal exposure to glucocorticoids is a key mechanism thought to underlie the early life programming of later life disease. There is substantial experimental data in animal models in support of this hypothesis. Emerging evidence suggests glucocorticoid programming may also occur in humans with some studies now linking maternal endogenous cortisol levels with size at birth and gestation at delivery. The dramatic changes to the maternal hypothalamic-pituitary-adrenal axis during pregnancy mean that large-scale studies in humans are challenging to conduct...
December 2016: Annales D'endocrinologie
https://www.readbyqxmd.com/read/27629575/breast-milk-cortisol-and-cortisone-concentrations-follow-the-diurnal-rhythm-of-maternal-hypothalamus-pituitary-adrenal-axis-activity
#9
Bibian van der Voorn, Marita de Waard, Johannes B van Goudoever, Joost Rotteveel, Annemieke C Heijboer, Martijn Jj Finken
BACKGROUND: Very preterm infants often receive donor milk from mothers who deliver at term, but its composition differs from that of their own mother's milk. Because breast-milk glucocorticoids can support developing neonates, we explored concentration variability within and between mothers. OBJECTIVE: We hypothesized that breast-milk glucocorticoid concentrations would be higher after very preterm delivery [gestational age (GA) <32 wk; study 1] and would follow the diurnal rhythm of maternal adrenocortical activity (study 2)...
September 14, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27617175/hsd1-and-aqp7-short-term-gene-regulation-by-cortisone-in-3t3-l1-adipocytes
#10
Tania Quesada-López, Laura González-Dávalos, Enrique Piña, Ofelia Mora
Adipose Tissue (AT) is a complex organ with a crucial regulatory role in energy metabolism and in the development of obesity and the Metabolic Syndrome (MS). Modified responses and the metabolism of hormones have been observed in visceral adiposity during obesity, specifically as related with cortisone. The objective of this study was to assess, in the 3T3-L1 adipocyte cell line, the short-term effect of cortisone on the expression of 11β-Hydroxysteroid dehydrogenase 1 (Hsd1), which is responsible for activation of cortisone into cortisol, and for Aquaporin 7 (Aqp7), involved in glycerol transport through the cell membrane...
July 2016: Adipocyte
https://www.readbyqxmd.com/read/27613574/anti-angiogenic-effect-of-a-palladium-ii-saccharinate-complex-of-terpyridine-in-vitro-and-in-vivo
#11
Elif I Ikitimur-Armutak, Ebru Gurel-Gurevin, H Tuba Kiyan, Seyma Aydinlik, Veysel Turan Yilmaz, Konstantinos Dimas, Engin Ulukaya
Anti-angiogenic activity of palladium (Pd)(II)-based complexes is unknown despite their quite powerful anticancer activity. This study was therefore carried out to evaluate both in vivo anti-angiogenic effect and in vitro cytotoxic activity of a Pd(II)-based complex. ([Pd(sac)(terpy)](sac)·4H2O(sac=saccharinate and terpy=2,2':6',2″-terpyridine)) on HUVEC cells. The anti-angiogenic activity of the complex was evaluated in vivo using the chick embryo chorioallantoic membrane (CAM) assay, tube formation assay and the cytotoxicity was screened using the MTT viability assays...
September 6, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27601777/multifactorial-monitoring-of-training-load-in-elite-rugby-sevens-players-cortisol-cortisone-ratio-as-a-valid-tool-of-training-load-monitoring
#12
T Bouaziz, E Makni, P Passelergue, Z Tabka, G Lac, W Moalla, K Chamari, M Elloumi
The effectiveness of selected physiological and perceptual measures for monitoring training load and fatigue was studied in 16 male elite rugby sevens players during a 6-week intense training block (IT) and 2-week tapering (TAP). Daily training load (TL) and strain (TS) as well as weekly total score of fatigue (TSF) were quantified respectively by the session-rating of perceived exertion (RPE) method and an 8-item questionnaire. Also, testing was performed and 24 h urinary cortisol (C), cortisone (Cn), adrenaline (A) and noradrenalin (NA) excretion was measured before (T0) and after the IT (T1) and after the TAP (T2)...
September 2016: Biology of Sport
https://www.readbyqxmd.com/read/27598456/no-association-between-hair-cortisol-or-cortisone-and-brain-morphology-in-children
#13
Ruoqing Chen, Ryan L Muetzel, Hanan El Marroun, Gerard Noppe, Elisabeth F C van Rossum, Vincent W Jaddoe, Frank C Verhulst, Tonya White, Fang Fang, Henning Tiemeier
Little is known about the relationship between the long-term hypothalamic-pituitary-adrenal (HPA) axis functioning and brain structure in children. Glucocorticoid in hair has emerged as an important biomarker of HPA activity. In this study, we investigated the associations of hair cortisol and cortisone concentrations with brain morphology in young children. We included 219 children aged 6-10 years from the Generation R Study in Rotterdam, the Netherlands. We examined cortisol and cortisone concentrations by hair analysis using liquid chromatography-tandem mass spectrometry, and assessed brain morphometric measures with structural magnetic resonance imaging...
August 24, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27581813/development-of-an-animal-borne-blood-collection-device-and-its-deployment-for-the-determination-of-cardiovascular-and-stress-hormones-in-submerged-phocid-seals
#14
Yoshio Takei, Ippei Suzuki, Marty Kwok-Shing Wong, Ryan Milne, Simon Moss, Katsufumi Sato, Ailsa Hall
An animal-borne blood sampler with data logging functions was developed for phocid seals which collected two blood samples for the comparison of endocrinological/biochemical parameters under two different conditions. The sampler can be triggered by preset hydrostatic pressure, acceleration (descending or ascending), temperature and time, and also manually by light. The sampling was reliable with >78% successful attempts to collect blood samples. Contamination of fluids in the tubing to the next blood sample was <1%, following the prior clearance of the tubing to a waste syringe...
August 31, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27578461/cortisol-intermediates-and-hydrocortisone-responsiveness-in-critical-neonatal-disease
#15
Abdelmoneim Khashana, Timo Saarela, Mika Ramet, Mikko Hallman
OBJECTIVE: Therapy-resistant hypotension complicates diseases in neonates. Our objective was to investigate whether lack of therapeutic response to plasma expanders and inotropes associates with serum levels of cortisol and its precursors. METHODS: We investigated 96 infants with hypotension and critical neonatal disease for cortisol metabolism and are divided into responders and non-responders to plasma expanders and inotropes. Serum concentrations of steroids were analysed soon after the onset of volume expansion and inotrope treatment for shock...
August 31, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27566093/ear-keloid-treated-with-infiltrated-non-cross-linked-hyaluronic-acid-and-cortisone-therapy
#16
Arianna DI Stadio
BACKGROUND: Several treatments are available to treat the keloid scar. Keloids have the tendency to recur after surgical removal and new treatments for keloid scars include radiotherapy, cryotherapy or compressive therapy. Topical treatments have been also used to treat this pathology, such as injections or medical device applications. CASE REPORT: A 33-year-old man came to our attention and we treated him for a keloid scar located between the ear's helical tubercle and the ante-helix upper root of the left ear...
September 2016: In Vivo
https://www.readbyqxmd.com/read/27554490/-temporomandibular-joint-arthropathy-in-situ-steroid-injection
#17
J Gagé, A Gallucci, M Arnaud, C Chossegros, J M Foletti
INTRODUCTION: Temporomandibular disorders (TMDs) affect the masticatory muscles and the temporomandibular joints (TMJs). TMDs most often result from occlusal and/or muscular disorders and are then called primary or idiopathic TMDs. Less frequently, TMDs are related to local (trauma, infection) or general (rheumatoid arthritis) causes and are then called secondary TMDs. A little known iatrogenic cause of secondary TDM is the osteoarthritis that may be induced by intra-articular cortisone injections...
September 2016: Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale
https://www.readbyqxmd.com/read/27554022/liquid-chromatography-quadrupole-linear-ion-trap-mass-spectrometry-for-quantitative-steroid-hormone-analysis-in-plasma-urine-saliva-and-hair
#18
Alexander Gaudl, Juergen Kratzsch, Yoon Ju Bae, Wieland Kiess, Joachim Thiery, Uta Ceglarek
Steroid analysis is being conquered by liquid chromatography tandem mass spectrometry (LC-MS/MS) benefiting from higher standardization, selectivity and diversity. Regarding high throughput in routine diagnostics rapid chromatography is mandatory. Introducing MS(3) (MS/MS/MS), specificity of mass spectrometric detection can be enhanced without sacrificing analysis time. 100mL of human plasma/serum, saliva, urine and 10-20mg of hair are used for the simultaneous quantification of 17α-hydroxyprogesterone, aldosterone, androstenedione, cortisol, cortisone, dehydroepiandrosterone sulfate (DHEAS), estradiol, progesterone, and testosterone using online solid phase extraction (SPE) LC-MS/MS or LC-MS(3)...
September 16, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27540461/effect-of-vitamin-d-supplementation-on-cardiovascular-disease-risk-factors-and-exercise-performance-in-healthy-participants-a-randomized-placebo-controlled-preliminary-study
#19
Emad A S Al-Dujaili, Nimrah Munir, Raquel Revuelta Iniesta
BACKGROUND AND OBJECTIVES: Evidence suggests associations between vitamin D deficiency and cardiovascular disease (CVD) risk factors, including hypertension and excessive cortisol levels. Also, vitamin D levels may impact exercise performance. Thus, we aimed to investigate the effects of vitamin D intake on cardiovascular risk factors, free urinary cortisol and exercise performance. METHODS: A randomized placebo-controlled single-blinded parallel trial was conducted in healthy participants (n = 15)...
August 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27533889/inhibition-of-lysyl-oxidase-by-cortisol-regeneration-in-human-amnion-implications-for-rupture-of-fetal-membranes
#20
Chao Liu, Chunming Guo, Wangsheng Wang, Ping Zhu, Wenjiao Li, Yabing Mi, Leslie Myatt, Kang Sun
The mechanisms underlying human parturition are still not understood, yet we need this knowledge to combat preterm birth. Fetal membranes express abundant 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), which converts inert cortisone to active cortisol. We examined whether cortisol regeneration in the amnion might play a role in human parturition through regulation of lysyl oxidase (LOX), a collagen cross-linking enzyme, thereby contributing to the rupture of fetal membranes. By using cultured human primary amnion fibroblasts, we demonstrated that, in addition to the induction of the key enzymes involved in prostaglandin E2 (PGE2) synthesis, cortisol stimulated 11β-HSD1 and inhibited LOX reciprocally...
October 2016: Endocrinology
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