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https://www.readbyqxmd.com/read/27914687/braf-nras-kit-tert-gnaq-gna11-mutation-profile-analysis-of-head-and-neck-mucosal-melanomas-a-study-of-42-cases
#1
Şule Öztürk Sari, İsmaİl Yilmaz, Orhun Çiğ Taşkin, Gİzem Narli, Fatma Şen, Şenol Çomoğlu, Pinar Firat, Bİlge Bİlgİç, Dİlek Yilmazbayhan, Yasemİn Özlük, Nesİmİ Büyükbabanİ
Head and neck mucosal melanoma (HNMuM), which occurs mostly in the sinonasal and oral cavity, constitutes less than 1% of all malignant melanomas. Treatment options fail to improve the prognosis of this aggressive tumour that has low overall survival rates. Thus, development of new targeted therapies is essential. Unfortunately, limited data exist regarding their molecular profile. BRAF, NRAS, KIT, TERT and GNAQ/GNA11 oncogene mutations were investigated in 42 HNMuMs (28 sinonasal, 13 oral, 1 nasopharyngeal)...
November 30, 2016: Pathology
https://www.readbyqxmd.com/read/27910020/cytoplasmic-immunoglobulin-light-chain-revelation-and-interphase-fluorescence-in-situ-hybridization-in-myeloma
#2
Sarah Moore, Jeffrey M Suttle, Mario Nicola
The cytogenetic analysis of plasma cell myeloma (PCM) allows stratification of patients so that prognosis may be determined and appropriate therapeutic options can be discussed. Owing to the patchy nature of the disease in the bone marrow (BM), the low proliferative activity of plasma cells and the cryptic nature of some PCM-associated cytogenetic changes, karyotypic analysis in this disease should be augmented with targeted interphase fluorescence in situ hybridization (FISH). Immunofluorescent revelation of cytoplasmic immunoglobulin light chains, together with interphase FISH (cIg-FISH), allows the identification of plasma cells within a sample so that they may be scored preferentially...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27892577/light-soaking-effects-and-capacitance-profiling-in-cu-in-ga-se2-thin-film-solar-cells-with-chemical-bath-deposited-zns-buffer-layers
#3
Hye-Jung Yu, Woo-Jung Lee, Jae-Hyung Wi, Dae-Hyung Cho, Won Seok Han, Yong-Duck Chung, Tae-Soo Kim, Jung-Hoon Song
We fabricated Cu(In,Ga)Se2 (CIGS) solar cells with chemical-bath deposited (CBD) ZnS buffer layers with different deposition times. The conversion efficiency and the fill factor of the CIGS solar cells reveal a strong dependence on the deposition time of CBD-ZnS films. In order to understand the detailed relationship between the heterojunction structure and the electronic properties of CIGS solar cells with different deposition times of CBD-ZnS films, capacitance-voltage (C-V) profiling measurements with additional laser illumination were performed...
November 28, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27872485/the-neuroprotective-action-of-dexmedetomidine-on-apoptosis-calcium-entry-and-oxidative-stress-in-cerebral-ischemia-induced-rats-contribution-of-trpm2-and-trpv1-channels
#4
Hatice Akpınar, Mustafa Nazıroğlu, İshak Suat Övey, Bilal Çiğ, Orhan Akpınar
Dexmedetomidine (DEX) may act as an antioxidant through regulation of TRPM2 and TRPV1 channel activations in the neurons by reducing cerebral ischemia-induced oxidative stress and apoptosis. The neuroprotective roles of DEX were tested on cerebral ischemia (ISC) in the cultures of rat primary hippocampal and DRG neurons. Fifty-six rats were divided into five groups. A placebo was given to control, sham control, and ISC groups, respectively. In the third group, ISC was induced. The DEX and ISC+DEX groups received intraperitoneal DEX (40 μg/kg) 3, 24, and 48 hours after ISC induction...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27833693/e-cigarette-blast-injury-complex-facial-fractures-and-pneumocephalus
#5
Benjamin A Archambeau, Stephanie Young, Carol Lee, Troy Pennington, Christopher Vanderbeek, Dan Miulli, John Culhane, Michael Neeki
Electronic cigarettes (also known as e-cigarettes or e-cigs) are becoming a popular method of recreational nicotine use over recent years. The growth of new brands and devices has been outpacing the FDA's ability to regulate them. As a result, some of these devices fail without warning, most likely from malfunction of the lithium-ion batteries that are in close proximity to volatile compounds within the device. Failures have occurred during both use and storage of the devices or their components. The subsequent injuries from several of these events, including full thickness burns requiring grafting and blast injuries, have been observed at Arrowhead Regional Medical Center, a regional trauma and burn center in southern California...
November 2016: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27829296/development-and-characterization-of-electronic-cigarette-exposure-generation-system-ecig-egs-for-the-physico-chemical-and-toxicological-assessment-of-electronic-cigarette-emissions
#6
Jiayuan Zhao, Georgios Pyrgiotakis, Philip Demokritou
Electronic cigarettes (e-cig) have been introduced as a nicotine replacement therapy and have gained increasing attention and popularity. However, while findings on possible toxicological implications continue to grow, major knowledge gaps on both the complex chemistry of the exposure and toxicity exist, prohibiting public health assessors from assessing risks. Here, a versatile electronic cigarette exposure generation system (Ecig-EGS) has been developed and characterized. Ecig-EGS allows generation of real world e-cig emission profiles under controlled operational conditions, real time monitoring and time-integrated particle/gas sampling for physico-chemical characterization, and toxicological assessment (both in vitro and in vivo)...
November 10, 2016: Inhalation Toxicology
https://www.readbyqxmd.com/read/27810679/e-cigarettes-as-a-source-of-toxic-and-potentially-carcinogenic-metals
#7
Catherine Ann Hess, Pablo Olmedo, Ana Navas-Acien, Walter Goessler, Joanna E Cohen, Ana Maria Rule
BACKGROUND AND AIMS: The popularity of electronic cigarette devices is growing worldwide. The health impact of e-cigarette use, however, remains unclear. E-cigarettes are marketed as a safer alternative to cigarettes. The aim of this research was the characterization and quantification of toxic metal concentrations in five, nationally popular brands of cig-a-like e-cigarettes. METHODS: We analyzed the cartomizer liquid in 10 cartomizer refills for each of five brands by Inductively Coupled Plasma Mass Spectrometry (ICP-MS)...
January 2017: Environmental Research
https://www.readbyqxmd.com/read/27791204/e-cigarettes-and-flavorings-induce-inflammatory-and-pro-senescence-responses-in-oral-epithelial-cells-and-periodontal-fibroblasts
#8
Isaac K Sundar, Fawad Javed, Georgios E Romanos, Irfan Rahman
Electronic-cigarettes (e-cigs) represent a significant and increasing proportion of tobacco product consumption, which may pose an oral health concern. Oxidative/carbonyl stress via protein carbonylation is an important factor in causing inflammation and DNA damage. This results in stress-induced premature senescence (a state of irreversible growth arrest which re-enforces chronic inflammation) in gingival epithelium, which may contribute to the pathogenesis of oral diseases. We show that e-cigs with flavorings cause increased oxidative/carbonyl stress and inflammatory cytokine release in human periodontal ligament fibroblasts, Human Gingival Epithelium Progenitors pooled (HGEPp), and epigingival 3D epithelium...
October 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27782451/new-insights-into-the-mo-cu-in-ga-se2-interface-in-thin-film-solar-cells-formation-and-properties-of-the-mose2-interfacial-layer
#9
T Klinkert, B Theys, G Patriarche, M Jubault, F Donsanti, J-F Guillemoles, D Lincot
Being at the origin of an ohmic contact, the MoSe2 interfacial layer at the Mo/Cu(In,Ga)Se2 interface in CIGS (Cu(In,Ga)Se2 and related compounds) based solar cells has allowed for very high light-to-electricity conversion efficiencies up to 22.3%. This article gives new insights into the formation and the structural properties of this interfacial layer. Different selenization-steps of a Mo covered glass substrate prior to the CIGS deposition by co-evaporation led to MoSe2 interfacial layers with varying thickness and orientation, as observed by x-ray diffraction and atomic resolution transmission electron microscopy...
October 21, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27738114/use-of-icsi-in-ivf-cycles-in-women-with-tubal-ligation-does-not-improve-pregnancy-or-live-birth-rates
#10
F W Grimstad, Ajay K Nangia, B Luke, J E Stern, W Mak
STUDY QUESTION: Does ICSI improve outcomes in ART cycles without male factor, specifically in couples with a history of tubal ligation as their infertility diagnosis? SUMMARY ANSWER: The use of ICSI showed no significant improvement in fertilization rate and resulted in lower pregnancy and live birth (LB) rates for women with the diagnosis of tubal ligation and no male factor. WHAT IS KNOWN ALREADY: Prior studies have suggested that ICSI use does not improve fertilization, pregnancy or LB rates in couples with non-male factor infertility...
October 13, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27721496/development-validation-and-application-of-a-device-to-measure-e-cigarette-users-puffing-topography
#11
Anthony Cunningham, Sandra Slayford, Carl Vas, Jodie Gee, Sandra Costigan, Krishna Prasad
With the rapidly rising popularity and substantial evolution of electronic cigarettes (e-cigarettes) in the past 5-6 years, how these devices are used by vapers and consumers' exposure to aerosol emissions need to be understood. We used puffing topography to measure directly product use. We adapted a cigarette puffing topography device for use with e-cigarettes. We performed validation using air and e-cigarette aerosol under multiple regimes. Consumer puffing topography was measured for 60 vapers provided with rechargeable "cig-a-like" or larger button-activated e-cigarettes, to use ad-libitum in two sessions...
October 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27681802/impact-of-smoke-free-regulations-on-smoking-prevalence-trends-in-spain
#12
Brenda B León-Gómez, Esther Colell, Joan R Villalbí, Gregorio Barrio, Antonia Domingo-Salvany
BACKGROUND: Studies assessing Spanish smoke-free laws have found a decrease in second-hand smoke exposure, but the impact of such laws on general smoking trends is not clear. This study proposes to analyse trends in the prevalence of smoking in Spain, including changes by educational level, following the implementation of smoke-free regulations (2005 and 2010). METHODS: Seven editions of the Spanish Household Survey on Alcohol and Drugs from 1999 to 2011 were used to analyse the standardised prevalence of daily smokers, the proportion of ex-daily smokers, and the average cigarettes smoked daily in both sexes and by educational level, among the population aged 15-64...
September 28, 2016: European Journal of Public Health
https://www.readbyqxmd.com/read/27668320/patterns-of-youth-tobacco-and-polytobacco-usage-the-shift-to-alternative-tobacco-products
#13
Paul T Harrell, Syeda Mahrukh H Naqvi, Andrew D Plunk, Ming Ji, Silvia S Martins
BACKGROUND: Despite significant declines in youth cigarette smoking, overall tobacco usage remains over 20% as non-cigarette tobacco product usage is increasingly common and polytobacco use (using 1+ tobacco product) remains steady. OBJECTIVES: The present study was designed to identify patterns of youth tobacco use and examine associations with sociodemographic characteristics and tobacco dependence. METHODS: The current analysis uses Latent Class Analysis (LCA) to examine the 6,958 tobacco users (n = 2,738 female) in the National Youth Tobacco Survey (2012 and 2013)...
September 26, 2016: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/27664506/meta-glare-a-meta-system-for-defining-your-own-computer-interpretable-guideline-system-architecture-and-acquisition
#14
Alessio Bottrighi, Paolo Terenziani
CONTEXT: Several different computer-assisted management systems of computer interpretable guidelines (CIGs) have been developed by the Artificial Intelligence in Medicine community. Each CIG system is characterized by a specific formalism to represent CIGs, and usually provides a manager to acquire, consult and execute them. Though there are several commonalities between most formalisms in the literature, each formalism has its own peculiarities. OBJECTIVE: The goal of our work is to provide a flexible support to the extension or definition of CIGs formalisms, and of their acquisition and execution engines...
September 2016: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/27619553/prohibition-of-e-cigarettes-in-the-us-are-prohibitions-where-alcohol-is-consumed-related-to-lower-alcohol-consumption
#15
Alexandra R Hershberger, Kenny A Karyadi, Melissa A Cyders
Recently, research has suggested negative consequences related to electronic cigarette (e-cig) use, including the increased risk for alcohol use and abuse. Previous work found that cigarette smoking ban legislation lowered overall smoking and alcohol use rates; however, researchers have not yet examined the potential effects of prohibiting e-cig use. The present study surveyed 617 individuals from a community-based online sample in the US (mean age = 33.33, SD = 10.50, 54.7 per cent female) who reported their smoking/e-cig use status, alcohol consumption, and the presence of e-cig prohibitions where they consume alcohol...
September 12, 2016: Journal of Public Health Policy
https://www.readbyqxmd.com/read/27604768/weight-centile-crossing-in-infancy-correlations-between-successive-months-show-evidence-of-growth-feedback-and-an-infant-child-growth-transition
#16
Tim J Cole, Atul Singhal, Mary S Fewtrell, Jonathan Ck Wells
BACKGROUND: Early rapid weight gain is associated with later overweight, which implies that weight centile crossing tracks over time. OBJECTIVE: Centile crossing is defined in terms of the change or deviation in weight z score during 1 mo, and the correlations between successive deviations are explored at different ages. DESIGN: Two Cambridge (United Kingdom) growth cohorts were used: Widdowson (1094 infants born during 1959-1965) and the Cambridge Infant Growth Study (CIGS; 255 infants born during 1984-1987), each with weights measured monthly in the first year...
October 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27596227/should-electronic-cigarette-use-be-covered-by-clean-indoor-air-laws
#17
Jessica M Yingst, Susan Veldheer, Erin Hammett, Shari Hrabovsky, Jonathan Foulds
BACKGROUND: Some jurisdictions have passed legislation that bans electronic cigarette (e-cig) use (vaping) in public places similarly to smoking. Many other jurisdictions have not yet determined how to regulate vaping in public places. This study examined the proportion of current e-cig users who find their vaping restricted in public places and further evaluated factors associated with the differences between restricted and unrestricted vapers. METHODS: 3960 experienced exclusive e-cig users completed an online survey from December 2012 to May 2014 about their e-cig use...
September 5, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27595637/smoking-status-is-inversely-associated-with-overall-diet-quality-findings-from-the-oriscav-lux-study
#18
Ala'a Alkerwi, Burcu Baydarlioglu, Nicolas Sauvageot, Saverio Stranges, Paul Lemmens, Nitin Shivappa, James R Hébert
BACKGROUND & AIMS: Relationships between food consumption/nutrient intake and tobacco smoking have been described in the literature. However, little is known about the association between smoking and overall diet quality. This study examined the associations between eight diet quality indices, namely, the Diet Quality Index-International (DQI-I), Recommendation Compliance Index (RCI), Dietary Approach to Stop Hypertension (DASH) score, Energy Density Score (EDS), Dietary Diversity Score (DDS), Recommended Food Score (RFS), non-Recommended Food Score (non-RFS), and Dietary Inflammatory Index (DII), and smoking status with a focus on smoking intensity...
August 24, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27588321/building-chronic-kidney-disease-clinical-practice-guidelines-using-the-openehr-guideline-definition-language
#19
Ching-Heng Lin, Ying-Chih Lo, Pei-Yuan Hung, Der-Ming Liou
BACKGROUND: As a result of the disease's high prevalence, chronic kidney disease (CKD) has become a global public health problem. A clinical decision support system that integrates with computer-interpretable guidelines (CIGs) should improve clinical outcomes and help to ensure patient safety. OBJECTIVES: The openEHR guideline definition language (GDL) is a formal language used to represent CIGs. This study explores the feasibility of using a GDL approach for CKD; it also attempts to identify any potential gaps between the ideal concept and reality...
September 2, 2016: Methods of Information in Medicine
https://www.readbyqxmd.com/read/27561948/effects-of-intermittent-pressure-imitating-rolling-manipulation-on-calcium-ion-homeostasis-in-human-skeletal-muscle-cells
#20
Hong Zhang, Howe Liu, Qing Lin, Guohui Zhang, David C Mason
BACKGROUND: Homeostasis imbalance of intracellular Ca(2+) is one of the key pathophysiological factors in skeletal muscle injuries. Such imbalance can cause significant change in the metabolism of Ca(2+)-related biomarkers in skeletal muscle, such as superoxide dismutase (SOD), malondialdehyde (MDA) and creatine kinase (CK). Measurements of these biomarkers can be used to evaluate the degree of damage to human skeletal muscle cells (HSKMCs) injury. Rolling manipulation is the most popular myofascial release technique in Traditional Chinese Medicine...
2016: BMC Complementary and Alternative Medicine
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