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https://www.readbyqxmd.com/read/28070620/nicotine-delivery-to-users-from-cigarettes-and-from-different-types-of-e-cigarettes
#1
Peter Hajek, Dunja Przulj, Anna Phillips, Rebecca Anderson, Hayden McRobbie
BACKGROUND: Delivering nicotine in the way smokers seek is likely to be the key factor in e-cigarette (EC) success in replacing cigarettes. We examined to what degree different types of EC mimic nicotine intake from cigarettes. METHODS: Twelve participants ('dual users' of EC and cigarettes) used their own brand cigarette and nine different EC brands. Blood samples were taken at baseline and at 2-min intervals for 10 min and again at 30 min. RESULTS: Eleven smokers provided usable data...
January 9, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28065790/comparison-of-cellular-and-transcriptomic-effects-between-electronic-cigarette-vapor-and-cigarette-smoke-in-human-bronchial-epithelial-cells
#2
Sébastien Anthérieu, Anne Garat, Nicolas Beauval, Mélissa Soyez, Delphine Allorge, Guillaume Garçon, Jean-Marc Lo-Guidice
The use of electronic cigarette (e-cig) can be considered as an alternative to smoking. However, due to a lack of thorough toxicological studies, absolute safety of these products cannot be guaranteed. The aim of this in vitro work was to investigate the potential toxicity of e-vapors generated by a smoking machine in human bronchial epithelial BEAS-2B cells cultured at air-liquid interface, in comparison to cigarette smoke (CS). Although CS decreased strongly cell viability from 48min exposure, e-vapors induced no cytotoxicity up to 288min exposure...
January 5, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28064201/a-method-for-classifying-user-reported-electronic-cigarette-liquid-flavors
#3
Jessica M Yingst, Susan Veldheer, Erin Hammett, Shari Hrabovsky, Jonathan Foulds
BACKGROUND: Along with the growth in popularity of electronic cigarette devices (e-cigs), the variety of e-cig liquids (e-liquid) available to users has also grown. Although some studies have published data about the use of flavored e-liquid, there is no standardized way to group flavors making it difficult to interpret the data and replicate results across studies. The current study describes a method to classify user-reported e-liquid flavors and presents the resulting proportion of users in each flavor group in a large online survey of e-cig users...
January 6, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28042597/the-effect-of-comparatively-framed-versus-similarity-framed-e-cigarette-and-snus-print-ads-on-young-adults-ad-and-product-perceptions
#4
Smita C Banerjee, Kathryn Greene, Yuelin Li, Jamie S Ostroff
OBJECTIVES: This study examined the effects of comparative-framing [C-F; ads highlighting differences between the advertised product and conventional cigarettes and/or smokeless tobacco products] versus similarity-framing (S-F; ads highlighting congruence with conventional cigarettes and/or smokeless tobacco products) in e-cigarette and snus ads on young adult smokers' and non-smokers' ad- and product-related perceptions. METHODS: One thousand fifty one (1,051) young adults (18-24 years; 76% women; 50% smokers) from existing consumer panels were recruited in a within-subjects quasi-experiment...
July 2016: Tobacco Regulatory Science
https://www.readbyqxmd.com/read/28027837/rapid-determination-of-six-carcinogenic-primary-aromatic-amines-in-mainstream-cigarette-smoke-by-two-dimensional-online-solid-phase-extraction-combined-with-liquid-chromatography-tandem-mass-spectrometry
#5
Zhenying Bie, Wei Lu, You Zhu, Yusong Chen, Hubo Ren, Lishun Ji
A fully automated, rapid, and reliable method for simultaneous determination of six carcinogenic primary aromatic amines (AAs), including o-toluidine (o-TOL), 2, 6-dimethylaniline (2, 6-DMA), o-anisidine (o-ASD), 1-naphthylamine (1-ANP), 2-naphthylamine (2-ANP), and 4-aminobiphenyl (4-ABP), in mainstream cigarette smoke was established. The proposed method was based on two-dimensional online solid phase extraction combined with liquid chromatography tandem mass spectrometry (SPE/LC-MS/MS). The particulate phase of the mainstream cigarette smoke was collected on a Cambridge filter pad and pretreated via ultrasonic extraction with 2% formic acid (FA), while the gas phase was trapped by 2% FA without pretreatment for determination...
December 21, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27997362/elucidating-the-relationship-between-crystallo-chemistry-and-optical-properties-of-cigs-nanocrystals
#6
Mahshid Ahmadi, Stevin S Pramana, Chris Boothroyd, Yeng Ming Lam
The performance of solar cells fabricated using Cu(In,Ga)(S,Se)2 nanocrystal (NC) inks synthesized using the hot injection method has yielded efficiencies up to 12% recently. The efficiency of these devices is highly dependent on the chemical composition and crystallographic quality of the NCs. The former has been extensively discussed as it can be easily correlated to the optical properties of the film, but detailed crystallographic structure of these NCs has scarcely been discussed and it can influence both the optical and electrical properties...
January 27, 2017: Nanotechnology
https://www.readbyqxmd.com/read/27990434/cornel-iridoid-glycoside-improves-locomotor-impairment-and-decreases-spinal-cord-damage-in-rats
#7
Wen-Jing Tang, Deng-Lei Ma, Cui-Cui Yang, Li Zhang, Ya-Li Li, Lan Zhang, Lin Li
Purpose. This study was to investigate the effects of cornel iridoid glycoside (CIG) on spinal cord injury (SCI) in rats. Methods. The thoracic cord (at T9) of rats was injured by clip compression for 30 sec. Locomotor function was assessed using the Basso, Beattie, and Bresnahan (BBB) rating scale. Neuroanatomic stereological parameters as well as Nogo-A, p75 neurotrophin receptor (p75NTR), and ROCKII expression were measured by histological processing, immunohistochemistry, and stereological analyses. The axons passing through the lesion site were detected by BDA tracing...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27934030/enhanced-photocurrents-with-zns-passivated-cu-in-ga-se-s-2-photocathodes-synthesized-using-a-nonvacuum-process-for-solar-water-splitting
#8
Sang Youn Chae, Se Jin Park, Sung Gyu Han, Hyejin Jung, Chae-Woong Kim, Chaehwan Jeong, Oh-Shim Joo, Byoung Koun Min, Yun Jeong Hwang
Chalcopyrite Cu(In,Ga)(Se,S)2 (CIGS) semiconductors are potential candidates for use in photoelectrochemical (PEC) hydrogen generation due to their excellent optical absorption properties and high conduction band edge position. In the present research, CIGS thin film was successfully prepared on a transparent substrate (F:SnO2 glass) using a solution-based process and applied for a photocathode in solar water splitting, which shows control of the surface state associated with sulfurization/selenization process significantly influences on the PEC activity...
December 7, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27914687/braf-nras-kit-tert-gnaq-gna11-mutation-profile-analysis-of-head-and-neck-mucosal-melanomas-a-study-of-42-cases
#9
Şule Öztürk Sari, İsmaİl Yilmaz, Orhun Çiğ Taşkin, Gİzem Narli, Fatma Şen, Şenol Çomoğlu, Pinar Firat, Bİlge Bİlgİç, Dİlek Yilmazbayhan, Yasemİn Özlük, Nesİmİ Büyükbabanİ
Head and neck mucosal melanoma (HNMuM), which occurs mostly in the sinonasal and oral cavity, constitutes less than 1% of all malignant melanomas. Treatment options fail to improve the prognosis of this aggressive tumour that has low overall survival rates. Thus, development of new targeted therapies is essential. Unfortunately, limited data exist regarding their molecular profile. BRAF, NRAS, KIT, TERT and GNAQ/GNA11 oncogene mutations were investigated in 42 HNMuMs (28 sinonasal, 13 oral, 1 nasopharyngeal)...
January 2017: Pathology
https://www.readbyqxmd.com/read/27910020/cytoplasmic-immunoglobulin-light-chain-revelation-and-interphase-fluorescence-in-situ-hybridization-in-myeloma
#10
Sarah Moore, Jeffrey M Suttle, Mario Nicola
The cytogenetic analysis of plasma cell myeloma (PCM) allows stratification of patients so that prognosis may be determined and appropriate therapeutic options can be discussed. Owing to the patchy nature of the disease in the bone marrow (BM), the low proliferative activity of plasma cells and the cryptic nature of some PCM-associated cytogenetic changes, karyotypic analysis in this disease should be augmented with targeted interphase fluorescence in situ hybridization (FISH). Immunofluorescent revelation of cytoplasmic immunoglobulin light chains, together with interphase FISH (cIg-FISH), allows the identification of plasma cells within a sample so that they may be scored preferentially...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27892577/light-soaking-effects-and-capacitance-profiling-in-cu-in-ga-se2-thin-film-solar-cells-with-chemical-bath-deposited-zns-buffer-layers
#11
Hye-Jung Yu, Woo-Jung Lee, Jae-Hyung Wi, Dae-Hyung Cho, Won Seok Han, Yong-Duck Chung, Tae-Soo Kim, Jung-Hoon Song
We fabricated Cu(In,Ga)Se2 (CIGS) solar cells with chemical-bath deposited (CBD) ZnS buffer layers with different deposition times. The conversion efficiency and the fill factor of the CIGS solar cells reveal a strong dependence on the deposition time of CBD-ZnS films. In order to understand the detailed relationship between the heterojunction structure and the electronic properties of CIGS solar cells with different deposition times of CBD-ZnS films, capacitance-voltage (C-V) profiling measurements with additional laser illumination were performed...
December 7, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27872485/the-neuroprotective-action-of-dexmedetomidine-on-apoptosis-calcium-entry-and-oxidative-stress-in-cerebral-ischemia-induced-rats-contribution-of-trpm2-and-trpv1-channels
#12
Hatice Akpınar, Mustafa Nazıroğlu, İshak Suat Övey, Bilal Çiğ, Orhan Akpınar
Dexmedetomidine (DEX) may act as an antioxidant through regulation of TRPM2 and TRPV1 channel activations in the neurons by reducing cerebral ischemia-induced oxidative stress and apoptosis. The neuroprotective roles of DEX were tested on cerebral ischemia (ISC) in the cultures of rat primary hippocampal and DRG neurons. Fifty-six rats were divided into five groups. A placebo was given to control, sham control, and ISC groups, respectively. In the third group, ISC was induced. The DEX and ISC+DEX groups received intraperitoneal DEX (40 μg/kg) 3, 24, and 48 hours after ISC induction...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27833693/e-cigarette-blast-injury-complex-facial-fractures-and-pneumocephalus
#13
Benjamin A Archambeau, Stephanie Young, Carol Lee, Troy Pennington, Christopher Vanderbeek, Dan Miulli, John Culhane, Michael Neeki
Electronic cigarettes (also known as e-cigarettes or e-cigs) are becoming a popular method of recreational nicotine use over recent years. The growth of new brands and devices has been outpacing the FDA's ability to regulate them. As a result, some of these devices fail without warning, most likely from malfunction of the lithium-ion batteries that are in close proximity to volatile compounds within the device. Failures have occurred during both use and storage of the devices or their components. The subsequent injuries from several of these events, including full thickness burns requiring grafting and blast injuries, have been observed at Arrowhead Regional Medical Center, a regional trauma and burn center in southern California...
November 2016: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27829296/development-and-characterization-of-electronic-cigarette-exposure-generation-system-ecig-egs-for-the-physico-chemical-and-toxicological-assessment-of-electronic-cigarette-emissions
#14
Jiayuan Zhao, Georgios Pyrgiotakis, Philip Demokritou
Electronic cigarettes (e-cig) have been introduced as a nicotine replacement therapy and have gained increasing attention and popularity. However, while findings on possible toxicological implications continue to grow, major knowledge gaps on both the complex chemistry of the exposure and toxicity exist, prohibiting public health assessors from assessing risks. Here, a versatile electronic cigarette exposure generation system (Ecig-EGS) has been developed and characterized. Ecig-EGS allows generation of real world e-cig emission profiles under controlled operational conditions, real time monitoring and time-integrated particle/gas sampling for physico-chemical characterization, and toxicological assessment (both in vitro and in vivo)...
December 2016: Inhalation Toxicology
https://www.readbyqxmd.com/read/27810679/e-cigarettes-as-a-source-of-toxic-and-potentially-carcinogenic-metals
#15
Catherine Ann Hess, Pablo Olmedo, Ana Navas-Acien, Walter Goessler, Joanna E Cohen, Ana Maria Rule
BACKGROUND AND AIMS: The popularity of electronic cigarette devices is growing worldwide. The health impact of e-cigarette use, however, remains unclear. E-cigarettes are marketed as a safer alternative to cigarettes. The aim of this research was the characterization and quantification of toxic metal concentrations in five, nationally popular brands of cig-a-like e-cigarettes. METHODS: We analyzed the cartomizer liquid in 10 cartomizer refills for each of five brands by Inductively Coupled Plasma Mass Spectrometry (ICP-MS)...
January 2017: Environmental Research
https://www.readbyqxmd.com/read/27791204/e-cigarettes-and-flavorings-induce-inflammatory-and-pro-senescence-responses-in-oral-epithelial-cells-and-periodontal-fibroblasts
#16
Isaac K Sundar, Fawad Javed, Georgios E Romanos, Irfan Rahman
Electronic-cigarettes (e-cigs) represent a significant and increasing proportion of tobacco product consumption, which may pose an oral health concern. Oxidative/carbonyl stress via protein carbonylation is an important factor in causing inflammation and DNA damage. This results in stress-induced premature senescence (a state of irreversible growth arrest which re-enforces chronic inflammation) in gingival epithelium, which may contribute to the pathogenesis of oral diseases. We show that e-cigs with flavorings cause increased oxidative/carbonyl stress and inflammatory cytokine release in human periodontal ligament fibroblasts, Human Gingival Epithelium Progenitors pooled (HGEPp), and epigingival 3D epithelium...
October 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27782451/new-insights-into-the-mo-cu-in-ga-se2-interface-in-thin-film-solar-cells-formation-and-properties-of-the-mose2-interfacial-layer
#17
T Klinkert, B Theys, G Patriarche, M Jubault, F Donsanti, J-F Guillemoles, D Lincot
Being at the origin of an ohmic contact, the MoSe2 interfacial layer at the Mo/Cu(In,Ga)Se2 interface in CIGS (Cu(In,Ga)Se2 and related compounds) based solar cells has allowed for very high light-to-electricity conversion efficiencies up to 22.3%. This article gives new insights into the formation and the structural properties of this interfacial layer. Different selenization-steps of a Mo covered glass substrate prior to the CIGS deposition by co-evaporation led to MoSe2 interfacial layers with varying thickness and orientation, as observed by x-ray diffraction and atomic resolution transmission electron microscopy...
October 21, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27738114/use-of-icsi-in-ivf-cycles-in-women-with-tubal-ligation-does-not-improve-pregnancy-or-live-birth-rates
#18
F W Grimstad, Ajay K Nangia, B Luke, J E Stern, W Mak
STUDY QUESTION: Does ICSI improve outcomes in ART cycles without male factor, specifically in couples with a history of tubal ligation as their infertility diagnosis? SUMMARY ANSWER: The use of ICSI showed no significant improvement in fertilization rate and resulted in lower pregnancy and live birth (LB) rates for women with the diagnosis of tubal ligation and no male factor. WHAT IS KNOWN ALREADY: Prior studies have suggested that ICSI use does not improve fertilization, pregnancy or LB rates in couples with non-male factor infertility...
October 13, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27721496/development-validation-and-application-of-a-device-to-measure-e-cigarette-users-puffing-topography
#19
Anthony Cunningham, Sandra Slayford, Carl Vas, Jodie Gee, Sandra Costigan, Krishna Prasad
With the rapidly rising popularity and substantial evolution of electronic cigarettes (e-cigarettes) in the past 5-6 years, how these devices are used by vapers and consumers' exposure to aerosol emissions need to be understood. We used puffing topography to measure directly product use. We adapted a cigarette puffing topography device for use with e-cigarettes. We performed validation using air and e-cigarette aerosol under multiple regimes. Consumer puffing topography was measured for 60 vapers provided with rechargeable "cig-a-like" or larger button-activated e-cigarettes, to use ad-libitum in two sessions...
October 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27681802/impact-of-smoke-free-regulations-on-smoking-prevalence-trends-in-spain
#20
Brenda B León-Gómez, Esther Colell, Joan R Villalbí, Gregorio Barrio, Antonia Domingo-Salvany
BACKGROUND: Studies assessing Spanish smoke-free laws have found a decrease in second-hand smoke exposure, but the impact of such laws on general smoking trends is not clear. This study proposes to analyse trends in the prevalence of smoking in Spain, including changes by educational level, following the implementation of smoke-free regulations (2005 and 2010). METHODS: Seven editions of the Spanish Household Survey on Alcohol and Drugs from 1999 to 2011 were used to analyse the standardised prevalence of daily smokers, the proportion of ex-daily smokers, and the average cigarettes smoked daily in both sexes and by educational level, among the population aged 15-64...
September 28, 2016: European Journal of Public Health
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